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    10453 results match your criteria Cronkhite-Canada Syndrome

    1 OF 210

    Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.
    J Pathol 2018 Apr 19. Epub 2018 Apr 19.
    Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
    N-WASP (WASL) is a widely expressed cytoskeletal signalling and scaffold protein also implicated in regulation of Wnt signalling and homeostatic maintenance of skin epithelial architecture. N-WASP mediates invasion of cancer cells in vitro and its depletion reduces invasion and metastatic dissemination of breast cancer. Given this role in cancer invasion and universal expression in the gastrointestinal tract, we explored a role for N-WASP in the initiation and progression of colorectal cancer. Read More

    Prevalence of thyroid diseases in familial adenomatous polyposis: a systematic review and meta-analysis.
    Fam Cancer 2018 Apr 16. Epub 2018 Apr 16.
    Division of Medical Genetics and Genomics, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
    Thyroid cancer (TC) is a known extra-intestinal manifestation and contributes to the mortality and morbidity in patients with familial adenomatous polyposis (FAP). Its exact prevalence is not well established and recent studies have shown an increasing number of TC in this patient population. The prevalence of benign thyroid masses and endocrinologic thyroid disorders are also poorly described. Read More

    Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis.
    Exp Mol Med 2018 Apr 13;50(4):21. Epub 2018 Apr 13.
    Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research Center, Chongqing, China.
    Colorectal cancer (CRC) is a disease involving a variety of genetic and environmental factors. Sirtuin-3 (Sirt3) is expressed at a low level in cancer tissues of CRC, but it is unclear how Sirt3 modulates colonic tumorigenesis. In this study, we found that gut microbiota play a central role in the resistance to CRC tumor formation in wild-type (WT) mice through APC (Adenomatous Polyposis Coli)-mutant mouse microbiota transfer via Wnt signaling. Read More

    Molecular cloning, polymorphism, and expression analysis of the LKB1/STK11 gene and its association with non-specific digestive disorder in rabbits.
    Mol Cell Biochem 2018 Apr 10. Epub 2018 Apr 10.
    Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu Campus, Huimin Road #211, Wenjiang, 611130, Sichuan, China.
    Liver kinase B1 (LKB1, also called STK11) encodes a serine/threonine kinase mutated in Peutz-Jeghers cancer syndrome characterized by gastrointestinal polyposis. Although LKB1 plays an important role in regulating energy homeostasis, cell growth, and metabolism via activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), nothing is known about its molecular characteristics and possible involvement in non-specific digestive disorder (NSDD) of rabbits. In the present study, we first cloned the coding sequence (CDS) of rabbit LKB1, which consisted of 1317 bp encoding 438 amino acids (AAs) and contained a highly conserved S_TKc kinase domain. Read More

    Antibiotic-mediated bacteriome depletion in Apc mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression.
    Cancer Med 2018 Apr 6. Epub 2018 Apr 6.
    Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
    Recent epidemiological evidence suggests that exposure to antibiotics in early-to-middle adulthood is associated with an increased risk of colorectal adenoma. However, mechanistic studies in established preclinical cancer to examine these claims are extremely limited. Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the Apc mouse, an established genetic model for familial adenomatous polyposis. Read More

    Sirolimus in Refractory Cronkhite-Canada Syndrome and Focus on Standard Treatment.
    J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618765893. Epub 2018 Mar 22.
    Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
    Cronkhite-Canada syndrome is a rare syndrome consisting of extensive gastrointestinal polyposis and ectodermal changes including cutaneous hyperpigmentation, alopecia, and onychodystrophy. We report the case of a 45-year-old Caucasian male patient who failed multiple treatments over 2 years including steroids, azathioprine, adalimumab, and cyclosporine. He had recurrent and prolonged hospitalizations because of diarrhea, abdominal pain, weight loss, and malnutrition. Read More

    Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective.
    J Dev Biol 2018 Mar 28;6(2). Epub 2018 Mar 28.
    Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.
    In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology. Read More

    An unusual case of hamartomatous polyposis with malignancy complication in a patient with ulcerative colitis treated with golimumab.
    Acta Gastroenterol Belg 2017 Oct-Dec;80(4):530-532
    Division of Gastroenterology, McGill University Health Center, 1650 Avenue Cedar, H3G 1A4, Montreal QC, Canada.
    We report an unusual case of hamartomatous polyposis with malignant complications in a patient with ulcerative colitis on golimumab and previous thiopurine therapy. This patient was evaluated for iron deficiency anemia and underwent hemicolectomy for extensive right-side predominant inflammatory pseudopolyps. Anemia persisted post-colectomy and subsequent gastroscopy showed a fungating polypoid lesion along with numerous carpet-like strawberry appearing polyps in the stomach extending from the gastro-esophageal junction to the distal part of the antrum, necessitating a gastrectomy. Read More

    APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
    Dev Cell 2018 Mar;44(5):566-581.e8
    Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:
    Adenomatous polyposis coli (APC) mutations cause Wnt pathway activation in human cancers. Current models for APC action emphasize its role in promoting β-catenin degradation downstream of Wnt receptors. Unexpectedly, we find that blocking Wnt receptor activity in APC-deficient cells inhibits Wnt signaling independently of Wnt ligand. Read More

    A Case of Adolescent Cronkhite-Canada Syndrome.
    Gastroenterology Res 2018 Feb 23;11(1):64-67. Epub 2018 Feb 23.
    Kaiser Clinic and Hospital, Sao Jose do Rio Preto, SP Brazil.
    The Cronkhite-Canada syndrome (CCS) was first reported in 1955, since then more than 500 cases have been reported, indicating an estimated incidence of one case per 1 million inhabitants. The syndrome occurs predominantly in male, with a ratio of three males to two females. Because of the rarity of the syndrome, there are no evidence-based therapies and the treatments described include a combination of therapies, but none is consistently effective. Read More

    Integration of lncRNA and mRNA Transcriptome Analyses Reveals Genes and Pathways Potentially Involved in Calf Intestinal Growth and Development during the Early Weeks of Life.
    Genes (Basel) 2018 Mar 5;9(3). Epub 2018 Mar 5.
    Agriculture and Agri-Food Canada, Sherbrooke Research and Development Centre, Sherbrooke, QC J1M 0C8, Canada.
    A better understanding of the factors that regulate growth and immune response of the gastrointestinal tract (GIT) of calves will promote informed management practices in calf rearing. This study aimed to explore genomics (messenger RNA (mRNA)) and epigenomics (long non-coding RNA (lncRNA)) mechanisms regulating the development of the rumen and ileum in calves. Thirty-two calves (≈5-days-old) were reared for 96 days following standard procedures. Read More

    KSHV/HHV8-Associated Extracavitary Primary Effusion Lymphoma Presenting as Multiple Lymphomatous Polyposis.
    Hum Pathol 2018 Mar 2. Epub 2018 Mar 2.
    Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California, USA 90048. Electronic address:
    Primary effusion lymphoma (PEL) is a distinct clinicopathologic entity usually characterized by presentation as a lymphomatous body cavity effusion in the absence of solid tumor mass or dissemination during its clinical course. PEL can also rarely occur as a solid lymphoma involving nodal and extranodal sites and is referred to as extracavitary PEL. Here we report a unique case of extracavitary PEL in a 49year-old HIV-seropositive patient, who presented with vague abdominal pain and 20 pound weight loss. Read More

    Massive intussusception caused by a solitary Peutz-Jeghers type hamartomatous polyp.
    Ann R Coll Surg Engl 2018 Apr 27;100(4):e91-e93. Epub 2018 Feb 27.
    Surgical Department, General Hospital of Agrinio , Agrinio, Aitoloakarnania , Greece.
    Intussusception is a rare cause of intestinal obstruction in adults and represents a diagnostic challenge for the surgeon. In the majority of cases, presenting symptoms are not specific, making preoperative diagnosis difficult. Several medical conditions may cause intestinal intussusception. Read More

    Computed tomography findings of diffuse gastrointestinal mantle cell lymphoma.
    Radiol Case Rep 2017 Dec 9;12(4):697-700. Epub 2017 Aug 9.
    Departamento de Radiologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil.
    Multiple lymphomatous polyposis is an uncommon type of primary non-Hodgkin's lymphoma, characterized by multiple lymphomatous polyps along the gastrointestinal tract. We present 2 cases of diffuse gastrointestinal involvement and illustrate radiological and pathologic findings. Read More

    Cowden syndrome: clinical case and a brief review.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Department of Dermatology and Venereology, Centro Hospitalar São João EPE, Porto, Portugal.
    Cowden syndrome is a rare genodermatosis of autosomal dominant inheritance characterized by multiple hamartomas in several organs and an increased risk of malignancies. We present the case of a 53-year-old man with a history of benign and malignant thyroid disease, intestinal polyposis, and Chiari malformation. He had several trichilemmomas, papillomatosis of the oral cavity, macular pigmentation of the glans penis, among other clinical features suggestive of Cowden syndrome. Read More

    Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells.
    Cell Death Dis 2018 Feb 15;9(3):255. Epub 2018 Feb 15.
    Cell & Developmental Biology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland.
    More than 90% of colorectal cancers carry mutations in Apc that drive tumourigenesis. A 'just-right' signalling model proposes that Apc mutations stimulate optimal, but not excessive Wnt signalling, resulting in a growth advantage of Apc mutant over wild-type cells. Reversal of this growth advantage constitutes a potential therapeutic approach. Read More

    Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis.
    Adv Biol Regul 2018 Jan 10. Epub 2018 Jan 10.
    Translational Research Center for Protein Function Control, Yonsei University, Seoul, South Korea; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea. Electronic address:
    Cancer development is usually driven by multiple genetic and molecular alterations rather than by a single defect. In the human colorectal cancer (CRC), series of mutations of genes are involved in the different stages of tumorigenesis. For example, adenomatous polyposis coli (APC) and KRAS mutations have been known to play roles in the initiation and progression of the tumorigenesis, respectively. Read More

    IKKα is required in the intestinal epithelial cells for tumour stemness.
    Br J Cancer 2018 Mar 13;118(6):839-846. Epub 2018 Feb 13.
    Cancer Research Program, Institut Mar d'Investigacions Mèdiques, CIBERONC, Hospital del Mar, Doctor Aiguader 88, 08003 Barcelona, Spain.
    Background: Colorectal cancer is a common cause of death in developed countries. Progression from adenoma to invasive carcinoma requires accumulation of mutations starting with the Adenomatous Polyposis Coli (Apc) gene. NF-κB signalling is a key element in cancer, mainly related to the activity of IKKβ. Read More

    Anti-inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer.
    Oncol Lett 2018 Jan 6;15(1):642-648. Epub 2017 Oct 6.
    Cancer Prevention Research Program, Palindrome Liaisons Consultants, Montvale, NJ 07645-1559, USA.
    Mutations in the adenomatous polyposis coli (Apc) tumor suppressor gene represent the primary genetic defect in colon carcinogenesis. Apc mouse models exhibit pre-invasive small intestinal adenomas. Cell culture models exhibiting Apc defects in the colon and quantifiable cancer risk provide a novel clinically relevant approach. Read More

    Mantle Cell Lymphoma with a Single Protruding Lesion as the Cause of Intussusception.
    Intern Med 2018 Feb 9. Epub 2018 Feb 9.
    Department of Gastroenterology, National Hospital Organization Fukuyama Medical Center, Japan.
    Mantle cell lymphoma (MCL) is a malignant lymphoma of the gastrointestinal tract that mostly presents as multiple lymphomatous polyposis (MLP); however, MLP with intussusception is rarely reported in MCL. Furthermore, a single protruding lesion with intussusception has never been reported in primary small intestinal MCL. A 70-year-old man presented with pain in the right lower abdomen. Read More

    DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.
    Nat Med 2018 Mar 12;24(3):262-270. Epub 2018 Feb 12.
    Vascular Biology and Therapeutic Program and Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, USA.
    Immunotherapy offers new options for cancer treatment, but efficacy varies across cancer types. Colorectal cancers (CRCs) are largely refractory to immune-checkpoint blockade, which suggests the presence of yet uncharacterized immune-suppressive mechanisms. Here we report that the loss of adenomatosis polyposis coli (APC) in intestinal tumor cells or of the tumor suppressor PTEN in melanoma cells upregulates the expression of Dickkopf-related protein 2 (DKK2), which, together with its receptor LRP5, provides an unconventional mechanism for tumor immune evasion. Read More

    Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.
    Science 2018 02 1;359(6375):592-597. Epub 2018 Feb 1.
    Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.
    Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated with precancerous lesions in hereditary CRC remains largely unknown. We studied colonic mucosa of patients with familial adenomatous polyposis (FAP), who develop benign precursor lesions (polyps) early in life. We identified patchy bacterial biofilms composed predominately of and Genes for colibactin () and toxin (), encoding secreted oncotoxins, were highly enriched in FAP patients' colonic mucosa compared to healthy individuals. Read More

    [Concurrent APC and MLH1mutations identified in a family affected with familial adenomatous polyposis].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Feb;35(1):84-88
    Department of Obstetrics and Gynecology, Department of Pathology, Peking University First Hospital, Beijing 100034, China. Email:
    OBJECTIVE To report on concurrent mutations of APC and MLH1 genes identified in a family affected with familial adenomatous polyposis(FAP). METHODS The proband was diagnosed with FAP based on her clinical manifestation, family history and histopathology examination. She developed endometrial epithelial neoplasia(EIN) two years later. Read More

    Adenocarcinoma in a Blind Loop of the Ileum 53 Years After an Ileotransversostomy Procedure.
    Am J Case Rep 2018 Feb 6;19:133-136. Epub 2018 Feb 6.
    Department of Surgery, National Hospital Organization Kanazawa Medical Center, Kanazawa, Ishikawa, Japan.
    BACKGROUND Primary small bowel cancer is a rare malignancy; the common histopathological types are carcinoid and adenocarcinoma. Inflammatory bowel diseases and familial adenomatous polyposis are known risk factors for small bowel cancer. Additionally, cases of surgery-induced small bowel adenocarcinoma are sometimes reported after ileostomy. Read More

    Insights into insulin resistance, lifestyle, and anthropometric measures of patients with prior colorectal cancer compared to controls: A National Health and Nutrition Examination Survey (NHANES) Study.
    Curr Probl Cancer 2018 Jan 5. Epub 2018 Jan 5.
    Section of Intestinal Neoplasia and Hereditary Polyposis (INHP), Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH; Comprehensive Cancer Center, The Ohio State University, Columbus, OH. Electronic address:
    Background: Insulin resistance (IR) increases the risk of index colorectal cancer (CRC) development. Limited data exist on IR values, lifestyle, and anthropometric alterations of patients after CRC diagnosis, a population at high risk for CRC recurrence.

    Methods: This is a retrospective cohort study using the National Health and Nutrition Examination Survey (NHANES), 1999-2010. Read More

    Mast Cell-Dependent CD8 T-cell Recruitment Mediates Immune Surveillance of Intestinal Tumors in Apc Mice.
    Cancer Immunol Res 2018 Jan 30. Epub 2018 Jan 30.
    James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, Kentucky.
    The presence of mast cells in some human colorectal cancers is a positive prognostic factor, but the basis for this association is incompletely understood. Here, we found that mice with a heterozygous mutation in the displayed reduced intestinal tumor burdens and increased survival in a chemokine decoy receptor, ACKR2-null background, which led to discovery of a critical role for mast cells in tumor defense. ACKR2Apc tumors showed increased infiltration of mast cells, their survival advantage was lost in mast cell-deficient ACKR2SAApc mice as the tumors grew rapidly, and adoptive transfer of mast cells restored control of tumor growth. Read More

    The Yin and Yang of Invariant Natural Killer T Cells in Tumor Immunity-Suppression of Tumor Immunity in the Intestine.
    Front Immunol 2017 10;8:1945. Epub 2018 Jan 10.
    Department of Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden.
    CD1d-restricted invariant natural killer T (iNKT) cells are known as early responding, potent regulatory cells of immune responses. Besides their established role in the regulation of inflammation and autoimmune disease, numerous studies have shown that iNKT cells have important functions in tumor immunosurveillance and control of tumor metastasis. Tumor-infiltrating T helper 1 (TH1)/cytotoxic T lymphocytes have been associated with a positive prognosis. Read More

    Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study.
    J Enzyme Inhib Med Chem 2018 Dec;33(1):428-432
    c Faculty of Medecine , Titu Maiorescu University , Bucharest , Romania.
    The gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by the excessive consumption of alcoholic or cholesterol-associated drinks. The present study, although it includes a very small number of cases diagnosed with colon diverticulosis-diverticulitis associated with polyposis at the same intestinal level, identifies the presence of increased circulating concentrations of this enzyme in the serum. Its serum levels are tracked "dynamically" throughout a year after the diagnosis and start of the therapy. Read More

    Autophagic flux is essential for the downregulation of D-dopachrome tautomerase by atractylenolide I to ameliorate intestinal adenoma formation.
    J Cell Commun Signal 2018 Jan 24. Epub 2018 Jan 24.
    School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
    Colorectal cancer is generally believed to progress through an adenoma - carcinoma sequence. Adenomatous polyposis coli (APC) mutations serve as the initiating event in adenoma formation. The Apc mouse harbors a mutation in the APC gene, which is similar or identical to the mutation found in individuals with familial adenomatous polyposis and 70% of all sporadic CRC cases. Read More

    [Consensus on clinical diagnosis, treatment and pedigree management of hereditary colorectal cancer in China].
    • Authors:
    Zhonghua Zhong Liu Za Zhi 2018 Jan;40(1):64-77
    Hereditary colorectal cancer can be divded into two categories based on the presence or absence of polyps. The first category is characterized by the development of polyposis, which includes familial adenomatous polyposis (FAP); The second category is nonpolyposis colorectal cancer, which is represented by Lynch syndrome. "Consensus on clinical diagnosis, treatment and pedigree management of hereditary colorectal cancer in China" developed by the Genetics Group of the Committee of Colorectal Cancer, Chinese Anti-cancer Association, is composed of three sections, including hereditary nonpolyposis syndrome, polyposis syndrome as well as genetic evaluation of hereditary colorectal cancer. Read More

    Cyclic-GMP-Elevating Agents Suppress Polyposis in mice by Targeting the Preneoplastic Epithelium.
    Cancer Prev Res (Phila) 2018 Feb 4;11(2):81-92. Epub 2018 Jan 4.
    Department of Biochemistry and Molecular Biology, Augusta University, Augusta, Georgia.
    The cGMP signaling axis has been implicated in the suppression of intestinal cancers, but the inhibitory mechanism and the extent to which this pathway can be targeted remains poorly understood. This study has tested the effect of cGMP-elevating agents on tumorigenesis in the mouse model of intestinal cancer. Treatment of mice with the receptor guanylyl-cyclase C (GCC) agonist linaclotide, or the phosphodiesterase-5 (PDE5) inhibitor sildenafil, significantly reduced the number of polyps per mouse (67% and 50%, respectively). Read More

    Multivisceral transplant is a viable treatment option for patients with non-resectable intra-abdominal fibromatosis.
    Clin Transplant 2018 Mar 18;32(3):e13186. Epub 2018 Jan 18.
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
    Background: Intra-abdominal fibromatosis often involves the mesentery root which is non-resectable by conventional surgery. Multivisceral transplant (MVT), as a potential cure to non-resectable fibromatosis, has rarely been reported and the prognosis is unknown.

    Methods: Six patients who underwent MVT for intra-abdominal fibromatosis were reviewed. Read More

    Germline variants are enriched in -wildtype Bannayan-Riley-Ruvalcaba syndrome.
    NPJ Genom Med 2017 18;2:37. Epub 2017 Dec 18.
    Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195 USA.
    Bannayan-Riley-Ruvalcaba syndrome (BRRS) is a rare congenital disorder classically characterized by macrocephaly in combination with intestinal hamartomatous polyposis, vascular malformations, lipomas, and genital lentiginosis. Germline mutations have been reported in up to 60% of BRRS patients. The remaining cases are of unknown genetic etiology. Read More

    A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8591
    aDepartment of Medical Genetics, Naval Medical University, Shanghai 200433, ChinabHebei North University, Zhangjiakou, Hebei Province, ChinacDepartment of Gastroenterology, Airforce General Hospital of PLA, Beijing, China.
    Rationale: Peutz-Jeghers syndrome (PJS) is a Mendelian autosomal dominant disease caused by mutations in the tumor suppressor gene, serine/threonine kinase 11 (STK11). The features of this syndrome include gastrointestinal (GI) hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer. Early onset of disease is often characterized by mucocutaneous pigmentation and intussusception due to GI polyps in childhood. Read More

    A giant and extensive solitary Peutz-Jeghers-type polyp in the antrum of stomach: Case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8466
    aDepartment of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinabDepartment of Gastroenterology, Xi'an Children's Hospital, Xi'an, Shaanxi, China.
    Rationale: A solitary Peutz-Jeghers-type polyp is a hamartomatous polyp which without either mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome (PJS). It can occur in all of the gastrointestinal tract, but it is extremely rare in the stomach.

    Patient Concerns: A 53-year-old man was admitted to the local hospital with left upper abdominal pain lasting 2 weeks. Read More

    Duodenal Adenomas in Patients With Multiple Colorectal Adenomas Without Germline APC or MUTYH Mutations.
    Dis Colon Rectum 2018 Jan;61(1):58-66
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
    Background: Patients with genetic adenomatous polyposis syndromes have an increased risk for duodenal cancer, and clear surveillance recommendations exist for this group. However, limited data are available on the duodenal phenotype of patients with multiple colorectal adenomas (10-99) without a germline APC or MUTYH mutation.

    Objective: We aimed to assess the frequency, extent, and progression of duodenal adenomas in patients with multiple colorectal adenomas without a germline APC or MUTYH mutation. Read More

    A novel bioactive derivative of eicosapentaenoic acid (EPA) suppresses intestinal tumor development in ApcΔ14/+ mice.
    Carcinogenesis 2018 Mar;39(3):429-438
    Center for Molecular Oncology, University of Connecticut Health, Farmington, CT, USA.
    Familial adenomatous polyposis (FAP) is a genetic disorder characterized by the development of hundreds of polyps throughout the colon. Without prophylactic colectomy, most individuals with FAP develop colorectal cancer at an early age. Treatment with EPA in the free fatty acid form (EPA-FFA) has been shown to reduce polyp burden in FAP patients. Read More

    Cronkhite-Canada syndrome causing pouch outlet obstruction 5 years after roux-en-y gastric bypass.
    Acta Chir Belg 2017 Dec 5:1-3. Epub 2017 Dec 5.
    a Dienst Abdominale, Kinder- en Reconstructieve Heelkunde , UZA , Antwerpen , Belgium.
    Objective: We present the case of a 57-year-old man with a history of Roux-en-Y gastric bypass (RYGB) and colonic polyps who presented with an upper gastrointestinal obstruction based on massive stomach polyposis in the pouch.

    Methods: Two months prior to this acute admission, he had undergone resection of the gastric remnant due to massive refractory intraluminal bleeding from a polypoid mass. Ten years earlier, right colectomy was performed due to hypertrophic polyposis unsuitable for endoscopic polypectomy. Read More

    [Advance in research on the correlation between genotypes of susceptible mutations and clinical phenotype of familial adenomatous polyposis].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Dec;34(6):919-923
    Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. Email:
    Familial adenomatous polyposis (FAP) is one of the most common hereditary colorectal cancers. Its intestinal and extra-intestinal manifestations are correlated with mutation sties of the APC gene. Potential gene modulation sites in patients who have typical clinical manifestations but with unidentified APC mutations are also discussed, which included MUTYH gene, AXIN gene and certain epigenetic changes. Read More

    [Current status of hereditary gastrointestinal neoplasms].
    Zhonghua Wei Chang Wai Ke Za Zhi 2017 Nov;20(11):1222-1226
    Gastrointestinal Surgery Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
    Gastric cancer and colorectal cancer are two common malignant tumors in digestive tract. 1% to 3% of gastric cancer and 5% to 15% of colorectal cancer are definitely hereditary cancer caused by germline gene mutation. Hereditary gastric cancer includes hereditary diffuse gastric cancer(HDGC) and hereditary intestinal gastric cancer (HIGC). Read More

    Polyposis deserves a perfect physical examination for final diagnosis: Bannayan-Riley-Ruvalcaba syndrome.
    Turk J Pediatr 2017 ;59(1):80-83
    Divisions of Pediatric Gastroenterology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
    Hızarcıoğlu-Gülşen H, Kılıç E, Dominguez-Garrido E, Aydemir Y, Utine GE, Saltık-Temizel İN. Polyposis deserves a perfect physical examination for final diagnosis: Bannayan-Riley-Ruvalcaba syndrome. Turk J Pediatr 2017; 59: 80-83. Read More

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