10,677 results match your criteria Cronkhite-Canada Syndrome


Large desmoid tumors in familial adenomatous polyposis: a successful outcome.

Autops Case Rep 2018 Oct-Dec;8(4):e2018045. Epub 2018 Sep 26.

Centro Hospitalar de São João, Department of Surgery. Porto, Portugal.

Desmoid tumors develop from connective tissue, fasciae, and aponeuroses, and may occur in the context of familial adenomatous polyposis or may arise sporadically; also, they may be extra-abdominal, intra-abdominal, or located in the abdominal wall. These benign tumors have a great aggressiveness with a high rate of local recurrence. Familial adenomatous polyposis is an inherited condition with autosomal dominant transmission, and is characterized by the development of multiple colonic and rectal adenomatous polyps, as well as desmoid tumors. Read More

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http://dx.doi.org/10.4322/acr.2018.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360820PMC
September 2018

Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium.

Sci Rep 2019 Feb 7;9(1):1629. Epub 2019 Feb 7.

Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic.

The first step in the development of human colorectal cancer is aberrant activation of the Wnt signaling pathway. Wnt signaling hyperactivation is predominantly caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene that encodes the pathway negative regulator. In order to identify genes affected by the Apc loss, we performed expression profiling of intestinal epithelium isolated from mice harboring a conditional Apc allele. Read More

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http://dx.doi.org/10.1038/s41598-018-38310-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367488PMC
February 2019

Major duodenal papilla prolapse in Cronkhite-Canada syndrome.

Endoscopy 2019 Feb 7. Epub 2019 Feb 7.

Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1055/a-0800-8148DOI Listing
February 2019
1 Read

Peutz-Jeghers Syndrome.

N Engl J Med 2019 Jan;380(5):472

R.G. Kar Medical College and Hospital, Kolkata, India

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http://dx.doi.org/10.1056/NEJMicm1806623DOI Listing
January 2019
1 Read

Identification of aggressive Gardner syndrome phenotype associated with a de novo APC Variant, c.4666dup.

Cold Spring Harb Mol Case Stud 2019 Jan 29. Epub 2019 Jan 29.

Mayo Clinic;

Gardner Syndrome describes a variant phenotype of familial adenomatous polyposis (FAP), characterized primarily by extracolonic lesions including osteomas, dental abnormalities, epidermal cysts, and soft tissue tumors. We describe a two-year old boy presenting with a 2 cm soft tissue mass of the forehead. Pathologic evaluation revealed a nuchal-type/Gardner-associated fibroma. Read More

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http://dx.doi.org/10.1101/mcs.a003640DOI Listing
January 2019
1 Read

Short- and Long-term Outcomes After Ileal Pouch Anal Anastomosis in Pediatric Patients: A Systematic Review.

Inflamm Bowel Dis 2019 Jan 18. Epub 2019 Jan 18.

Division ofPediatric Surgery, Mayo Clinic, Rochester Minnesota, USA.

Background: Restorative proctocolectomy and ileal pouch anal anastomosis (IPAA) has become the procedures of choice for restoration of intestinal continuity in ulcerative colitis or familial adenomatous polyposis. This systematic review aims to assess short-term postoperative and long-term functional outcomes in pediatric patients undergoing IPAA.

Methods: A literature search was performed for all publications of pediatric IPAA in which short- and long-term outcomes were reported. Read More

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http://dx.doi.org/10.1093/ibd/izy375DOI Listing
January 2019
1 Read
4.464 Impact Factor

Challenges and pitfalls of investigating duodenal cancer in patients with familial adenomatous polyposis.

Gastrointest Endosc 2019 02;89(2):355-356

Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Department of Gastroenterology and Hepatology, Cancer Center Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/j.gie.2018.09.044DOI Listing
February 2019
1 Read

-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer.

Nutrients 2019 Jan 15;11(1). Epub 2019 Jan 15.

The University of Arizona Cancer Center, Tucson, AZ 85724, USA.

The farnesoid-X-receptor (FXR) protects against inflammation and cancer of the colon through maintenance of intestinal bile acid (BA) homeostasis. Conversely, higher levels of BA and cyclooxygenase-2 (COX-2) are risk factors for inflammation and cancer of the colon. In the United States, -6 linoleic acid (LA) is the most commonly used dietary vegetable fat. Read More

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http://dx.doi.org/10.3390/nu11010171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356359PMC
January 2019
1 Read

A Case Report of Cronkhite-Canada Syndrome Complicated by Membranous Nephropathy.

Case Rep Nephrol Dial 2018 Sep-Dec;8(3):261-267. Epub 2018 Nov 27.

Division of Nephrology and Hypertension, Mayo Clinic in Arizona, Scottsdale, Arizona, USA.

Cronkhite-Canada syndrome (CCS) is a very rare disorder with less than 500 reported cases. It is characterized by extensive gastrointestinal polyposis and ectodermal anomalies including alopecia, cutaneous hyperpigmentation, and onychodystrophy. Only 3 cases of associated kidney disease (membranous nephropathy [MN]) have been reported. Read More

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https://www.karger.com/Article/FullText/494714
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http://dx.doi.org/10.1159/000494714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323406PMC
November 2018
7 Reads

[Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1323-1327

Department of Gastroenterology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China.

Objective: To explore the clinical features, pathological features, gene test results, diagnosis, treatment and prognosis of Peutz-Jeghers syndrome(PJS).
 Methods: We retrospectively analyzed clinical data of 46 hospitalized cases of PJS during 2007 and 2017.
 Results: All 46 patients had mucocutaneous melanin pigmentation and multiple gastrointestinal polyposis. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.007DOI Listing
December 2018
4 Reads

[Small Bowel Tumors and Polyposis: How to Approach and Manage?]

Authors:
Bong Min Ko

Korean J Gastroenterol 2018 Dec;72(6):277-280

Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.

Although small bowel the mainly occupies the most part of the gastrointestinal tract, small intestine tumors are rare, insidious in clinical presentation, and frequently represent a diagnostic and management challenge. Small bowel tumors are generally classified as epithelial, mesenchymal, lymphoproliferative, or metastatic. Familial adenomatous polyposis and Peutz-Jeghers syndrome are the most common inherited intestinal polyposis syndromes. Read More

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http://dx.doi.org/10.4166/kjg.2018.72.6.277DOI Listing
December 2018
1 Read

Shortcuts to intestinal carcinogenesis by genetic engineering in organoids.

Cancer Sci 2019 Jan 13. Epub 2019 Jan 13.

Department of Molecular Carcinogenesis, Chiba Cancer Center Research Institute, Chiba, Japan.

Inactivation of the Adenomatous polyposis coli (APC) gene is an initiating and the most relevant event in most sporadic cases of colorectal cancer, providing a rationale for using Apc-mutant mice as the disease model. Whereas carcinogenesis has been observed only at the organism level, the recent development of the organoid culture technique has enabled long-term propagation of intestinal stem cells in a physiological setting, raising the possibility that organoids could serve as an alternative platform for modeling colon carcinogenesis. Indeed, it is demonstrated in the present study that lentivirus-based RNAi-mediated knockdown of Apc in intestinal organoids gave rise to subcutaneous tumors upon inoculation in immunodeficient mice. Read More

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http://dx.doi.org/10.1111/cas.13938DOI Listing
January 2019
1 Read

Diffuse Intense Intestinal FDG Activity in a Patient With Familial Adenomatous Polyposis.

Clin Nucl Med 2019 Mar;44(3):262-264

Department of Nuclear Medicine, Zigong First People's Hospital, Zigong, Sichuan, PR China.

Familial adenomatous polyposis is a rare autosomal dominant intestinal syndrome with a high rate of malignant transformation. Here, we report a 20-year-old woman with a diagnosis of familial adenomatous polyposis by pathologic examination after colonoscopy biopsy, who underwent an F-FDG PET/CT to assess the extent of this disease. The images showed diffuse elevated FDG uptake along the entire colorectum. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002438DOI Listing
March 2019
2 Reads

Management of Peutz-Jeghers syndromes in children and adolescents: A Position Paper from the ESPGHAN Polyposis Working Group.

J Pediatr Gastroenterol Nutr 2018 Dec 19. Epub 2018 Dec 19.

St Mark's Hospital Polyposis Registry UK.

Peutz-jeghers syndrome (PJS) is a well-described inherited syndrome, characterised by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. Development of small bowel intestinal polyps may lead to intussusception in children may require emergency laparotomy with potential loss of bowel. Gastrointestinal (GI) polyps may lead to bleeding and anaemia. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002248DOI Listing
December 2018
7 Reads

A striking flail chest: a rare manifestation in Cronkhite-Canada syndrome.

Intest Res 2019 Jan 14;17(1):155-156. Epub 2018 Dec 14.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.5217/ir.2018.00132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361013PMC
January 2019
1 Read

Multiple Gastrointestinal Cancers in a Single Patient-a Rare Clinical Entity.

Indian J Surg Oncol 2018 Dec 16;9(4):633-635. Epub 2018 May 16.

Department of Surgical Oncology, BLK Hospital, Rajinder Place, New Delhi, 110008 India.

Multiple gastrointestinal cancers in a single patient is a rare entity. In our study, we are showing the clinical presentation and management of these patients. A fifty-nine-year-old asthenic male (already treated case of metachronous colorectal cancer in 2008 and 2011) presented with complaints of generalized weakness and fatigue. Read More

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http://link.springer.com/10.1007/s13193-018-0770-6
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http://dx.doi.org/10.1007/s13193-018-0770-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265184PMC
December 2018
10 Reads

Laparoscopy adjuvant total colorectal resection for the treatment of familial adenomatous polyposis (FAP).

Clin Transl Oncol 2018 Nov 21. Epub 2018 Nov 21.

Department of Colorectal Surgery, Tianjin Union Medical Center, 190 Jieyuan Road, Tianjin, 300121, People's Republic of China.

Objective: To discuss and evaluate the safety and value of laparoscopy adjuvant total colorectal resection for the treatment of familial adenomatous polyposis (FAP).

Methods: From March 2010 to June 2015, 38 cases were retrospectively analyzed and divided into 2 groups, of which 17 cases used laparoscopy adjuvant total colorectal resection, and 21 cases used conventional laparotomy. Clinical data were obtained, and the safety and prognosis were observed. Read More

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http://link.springer.com/10.1007/s12094-018-1979-0
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http://dx.doi.org/10.1007/s12094-018-1979-0DOI Listing
November 2018
7 Reads

Gardner syndrome with maxillofacial manifestation: A case report.

Spec Care Dentist 2019 Jan 12;39(1):65-71. Epub 2018 Nov 12.

Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Gardner syndrome is a hereditary disease in which patients develop gastrointestinal polyps, osteomas, desmoid tumors, epidermoid cysts, fibromas, lipomas, and retinal lesions. Dental abnormalities such as supernumerary or impacted teeth, odontomas and dentigerous cysts are also reported. The most serious concern in this syndrome is the extremely high risk of gastrointestinal polyps undergoing malignant transformation. Read More

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http://doi.wiley.com/10.1111/scd.12339
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http://dx.doi.org/10.1111/scd.12339DOI Listing
January 2019
8 Reads

Bone and dental abnormalities as first signs of familial Gardner's syndrome in a Chinese family: a literature review and a case report.

Med Sci (Paris) 2018 Oct 7;34 Focus issue F1:20-25. Epub 2018 Nov 7.

M.S., D.D.S., Attending doctor, Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University. 79# Qingchun Road, Hangzhou 310003, People's Republic of China.

Gardner's syndrome (GS) is an autosomal dominant disease characterized by the presence of familial adenomatous polyposis (FAP) as well as extraintestinal manifestations such as osteomas, dental anomalies, epidermoid cysts and ocular abnormalities. These intestinal polyps carry a 100% risk of malignant change, so early diagnosis is crucial. As craniofacial osteomas and dental anomalies of GS usually precede gastrointestinal symptoms, otolaryngologists, oral surgeons and dentists play an important role in the diagnosis of GS. Read More

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http://dx.doi.org/10.1051/medsci/201834f104DOI Listing
October 2018

TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling.

Nat Cell Biol 2018 Dec 29;20(12):1421-1433. Epub 2018 Oct 29.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Vesicular acidification and trafficking are associated with various cellular processes. However, their pathologic relevance to cancer remains elusive. We identified transmembrane protein 9 (TMEM9) as a vesicular acidification regulator. Read More

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http://www.nature.com/articles/s41556-018-0219-8
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http://dx.doi.org/10.1038/s41556-018-0219-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261670PMC
December 2018
17 Reads
19.680 Impact Factor

Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer.

J Biol Chem 2018 Nov 24;293(48):18770-18778. Epub 2018 Oct 24.

From Cancer Prevention Pharmaceuticals, Tucson, Arizona 85718 and.

Cancer is a set of diseases characterized by uncontrolled cell growth. In certain cancers of the gastrointestinal tract, the adenomatous polyposis coli (APC) tumor suppressor gene is altered in either germline or somatic cells and causes formation of risk factors, such as benign colonic or intestinal neoplasia, which can progress to invasive cancer. APC is a key component of the WNT pathway, contributing to normal GI tract development, and APC alteration results in dysregulation of the pathway for production of polyamines, which are ubiquitous cations essential for cell growth. Read More

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http://www.jbc.org/lookup/doi/10.1074/jbc.TM118.003343
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http://dx.doi.org/10.1074/jbc.TM118.003343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290143PMC
November 2018
6 Reads

Aspects of the Natural History of Sessile Serrated Adenomas/Polyps: Risk Indicators for Carcinogenesis in the Colorectal Mucosa?

Dis Colon Rectum 2018 12;61(12):1380-1385

Department of Colorectal Surgery, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Background: Sessile serrated adenomas/polyps are potentially premalignant colorectal lesions that are precursors to colorectal cancer arising via CpG island methylator phenotype. They are caused by the combination of a BRAF mutation and promoter hypermethylation. DNA methylation is an age-dependent phenomenon in the right colon, and we would expect the occurrence and severity of serrated neoplasia to reflect this. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001208DOI Listing
December 2018
10 Reads

[Clinicopathologic features of Cronkhite-Canada syndrome and the significance of IgG4-positive plasma cells infiltration].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):753-757

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

To analyze the clinical and pathological features of Cronkhite-Canada syndrome (CCS), and to investigate the significance of IgG4 positive plasma cell infiltration. Clinical presentations, endoscopic appearances and morphological features of 18 patients diagnosed with CCS at Peking Union Medical College Hospital during 2000-2016 were included in the study.There were 11 male and 7 female patients. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.10.004DOI Listing
October 2018
8 Reads

High-throughput metabolomics for discovering metabolic biomarkers from intestinal tumorigenesis in APC mice based on liquid chromatography/mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 2;1100-1101:131-139. Epub 2018 Oct 2.

Gastroenterology department, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, 157000, China.

As a major public health concern, colon cancer is one of the most common cancer types, which is also the second cause of cancer death in developed countries and the third most common cancer in other parts of the world. It was reported that patients diagnosed at early stage have a chance to obtain 5-year survival rates at least compared to patients with late stage. Facing the multistep process in intestinal tumorigenesis, there is an urgent need to develop more effective early detection strategies for ameliorating the patient clinical outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183112
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http://dx.doi.org/10.1016/j.jchromb.2018.09.042DOI Listing
November 2018
1 Read
2.729 Impact Factor

Unusual complication in patient with Gardner's syndrome: Coexistence of triple gastrointestinal perforation and lower gastrointestinal bleeding: A case report and review of literature.

World J Clin Cases 2018 Sep;6(10):393-397

Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey.

Gardner's syndrome (GS) is a rare syndrome with autosomal dominant inheritance, which is characterized by multiple intestinal polyps, dental anomalies, desmoid tumors, and soft tissue tumors. All gastrointestinal symptoms seen in GS are associated with the underlying familial adenomatosis polyposis and abdominal desmoid tumors, with the most common symptoms being anemia, lower gastrointestinal bleeding, abdominal pain, diarrhea, obstruction, and mucous defecation. To our best knowledge, no case of GS that has presented with gastrointestinal perforation and bleeding has ever been reported in the English language medical literature. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i10.393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163136PMC
September 2018
4 Reads

Synonymous mutation adenomatous polyposis coliΔ486s affects exon splicing and may predispose patients to adenomatous polyposis coli/mutY DNA glycosylase mutation‑negative familial adenomatous polyposis.

Mol Med Rep 2018 Dec 20;18(6):4931-4939. Epub 2018 Sep 20.

Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.

Familial adenomatous polyposis (FAP) is an autosomal dominant‑inherited colorectal cancer. Recent advances in genetics have indicated that the majority of patients with FAP carry germline mutations of the adenomatous polyposis coli (APC) and mutY DNA glycosylase (MUTYH) genes. However, a large subset of families with a history of FAP have undetectable pathogenic alterations, termed APC/MUTYH mutation‑negative FAP. Read More

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http://dx.doi.org/10.3892/mmr.2018.9495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236305PMC
December 2018
2 Reads

Gardener-associated fibroma: an unusual cause of upper airway obstruction.

BMJ Case Rep 2018 Sep 28;2018. Epub 2018 Sep 28.

Department of Otorhinolaryngology, Royal Manchester Children's Hospital, Manchester, UK.

We present the first case of upper airway obstruction secondary to a retropharyngeal Gardner-associated fibroma (GAF). A 16-month-old infant presented with a 3-month history of worsening dyspnoea and apnoeic episodes. Examination revealed stridor and left-sided retropharyngeal asymmetry. Read More

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http://dx.doi.org/10.1136/bcr-2018-225079DOI Listing
September 2018
2 Reads

A novel large germ line deletion in adenomatous polyposis coli (APC) gene associated with familial adenomatous polyposis.

Mol Genet Genomic Med 2018 11 26;6(6):1031-1040. Epub 2018 Sep 26.

Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Familial adenomatous polyposis (FAP) is a familial colorectal cancer predisposition syndrome characterized by the development of numerous colorectal polyps, which is inherited in an autosomal dominant manner. FAP is caused by germ line mutations in adenomatous polyposis coli (APC) gene. Here, we described the identification of a causative APC gene deletion associated with FAP in an Iranian family. Read More

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http://doi.wiley.com/10.1002/mgg3.479
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http://dx.doi.org/10.1002/mgg3.479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305644PMC
November 2018
3 Reads

[Peutz-Jegher syndrome presenting with intussusception].

Laeknabladid 2018 Oktober;104(10):439-441

Surgical unit at Landspítali, University Hospital, Iceland.

In this case report we describe a patient with a confirmed diagnosis of Peutz-Jegher syndrome. A diagnosis made from a positive tissue sample from the small bowels and characteristic hyperpigmentation on the patient's lips. This particular patient wasn't diagnosed till he got intussusception which required an operation. Read More

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http://dx.doi.org/10.17992/lbl.2018.10.200DOI Listing
January 2019
1 Read

Clinical practice guideline. Diagnosis and prevention of colorectal cancer. 2018 Update.

Gastroenterol Hepatol 2018 Nov 20;41(9):585-596. Epub 2018 Sep 20.

Servicio de Aparato Digestivo, Complexo Hospitalario Universitario de Ourense, Instituto de Investigación Sanitaria Galicia Sur, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Ourense, España.

This document updates the recommendations made by the Spanish Society of Family and Community Medicine and the Spanish Association of Gastroenterology for the diagnosis and prevention of colorectal cancer (CRC). In order to evaluate the quality of the evidence and determine the recommendation levels of the interventions, we used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology. This document establishes optimal delay intervals based on symptoms and the faecal immunochemical test (FIT) and recommends reducing the barriers for diagnostic confirmation in symptomatic subjects. Read More

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http://dx.doi.org/10.1016/j.gastrohep.2018.07.012DOI Listing
November 2018
2 Reads

Dual gene deficient models of Apc mouse in assessing molecular mechanisms of intestinal carcinogenesis.

Biomed Pharmacother 2018 Dec 20;108:600-609. Epub 2018 Sep 20.

Department of Pharmacy, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China. Electronic address:

The Apc mouse, carrying an inactivated allele of the adenomatous polyposis coli (Apc) gene, is a widely used animal model of human colorectal tumorigenesis. While crossed with other gene knockout or knock-in mice, these mice possess advantages in investigation of human intestinal tumorigenesis. Intestinal tumor pathogenesis involves multiple gene alterations; thus, various double gene deficiency models could provide novel insights into molecular mechanisms of tumor biology, as well as gene-gene interactions involved in intestinal tumor development and assessment of novel strategies for preventing and treating intestinal cancer. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.09.056DOI Listing
December 2018
2 Reads
2.020 Impact Factor

Reassessing colectomy in young patients with familial adenomatous polyposis.

Gastrointest Endosc 2018 10;88(4):734-736

Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico.

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http://dx.doi.org/10.1016/j.gie.2018.07.001DOI Listing
October 2018

The Effects of Berberine on the Gut Microbiota in Apc Mice Fed with a High Fat Diet.

Molecules 2018 Sep 8;23(9). Epub 2018 Sep 8.

State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Berberine (BBR) has been extensively reported to inhibit colorectal cancer (CRC) development, though its bioavailability is poor. Nowadays, an increasing number of studies have shown that BBR significantly accumulates in the intestines and could regulate gut microbiota in obesity. The purpose of this study was to further explore the effects of BBR on gut microbiota in Apc mice receiving a high fat diet (HFD). Read More

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http://www.mdpi.com/1420-3049/23/9/2298
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http://dx.doi.org/10.3390/molecules23092298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225274PMC
September 2018
9 Reads

A Case Report of a Young Adult With Progressive Bloody Diarrhea, Protein-Losing Enteropathy, and Extended Polyposis Coli.

Gastroenterology 2019 01 8;156(1):e10-e11. Epub 2018 Sep 8.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2018.08.054DOI Listing
January 2019
1 Read

A Rare Case of Colonic Intussusception in an Adult.

Gastroenterology 2019 01 7;156(1):26-28. Epub 2018 Sep 7.

Department of Gastroenterology, Kyoto City Hospital, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2018.07.049DOI Listing
January 2019

An intestinal stem cell niche in mutated neoplasia targetable by CtBP inhibition.

Oncotarget 2018 Aug 21;9(65):32408-32418. Epub 2018 Aug 21.

Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

C-terminal binding protein 2 (CtBP2) drives intestinal polyposis in the mouse model of human Familial Adenomatous Polyposis. As CtBP2 is targetable by an inhibitor of its dehydrogenase domain, understanding CtBP2's role in adenoma formation is necessary to optimize CtBP-targeted therapies in mutated human neoplasia. Tumor initiating cell (TIC) populations were substantially decreased in intestinal epithelia. Read More

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http://dx.doi.org/10.18632/oncotarget.25784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126694PMC

Life After Surgery: Surgeon Assessments of Quality of Life Among Patients With Familial Adenomatous Polyposis.

Dis Colon Rectum 2018 Oct;61(10):1217-1222

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Background: Without prophylactic surgery, patients with familial adenomatous polyposis are at high risk for colorectal cancer development. Various surgical options for prophylaxis are available. Patient decision-making for preventative treatments is often influenced by the preferences of healthcare providers. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001146DOI Listing
October 2018
8 Reads

The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer.

PLoS Genet 2018 09 6;14(9):e1007611. Epub 2018 Sep 6.

Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Conservation over three mammalian genera-the mouse, rat, and human-has been found for a subset of the transcripts whose level differs between the adenoma and normal epithelium of the colon. Pde4b is one of the triply conserved transcripts whose level is enhanced both in the colonic adenoma and in the normal colonic epithelium, especially adjacent to adenomas. It encodes the phosphodiesterase PDE4B, specific for cAMP. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143270PMC
September 2018
1 Read

Incidentally detected adrenocortical carcinoma in familial adenomatous polyposis: an unusual presentation of a hereditary cancer syndrome.

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.1136/bcr-2018-226799DOI Listing
September 2018
5 Reads

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells.

Nat Commun 2018 09 3;9(1):3573. Epub 2018 Sep 3.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, Thalkirchner Strasse 36, D-80337, Munich, Germany.

The gene encoding the transcription factor TFAP4/AP4 represents a direct target of the c-MYC oncoprotein. Here, we deleted Ap4 in Apc mice, a preclinical model of inherited colorectal cancer. Ap4 deficiency extends their average survival by 110 days and decreases the formation of intestinal adenomas and tumor-derived organoids. Read More

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http://dx.doi.org/10.1038/s41467-018-06001-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120921PMC
September 2018
15 Reads

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format.

J Vis Exp 2018 08 20(138). Epub 2018 Aug 20.

Department of Tumor Pathology, Hamamatsu University School of Medicine.

The quantitative analysis of human genetic variation is crucial for understanding the molecular characteristics of serious medical conditions, such as tumors. Because digital polymerase chain reactions (PCR) enable the precise quantification of DNA copy number variants, they are becoming an essential tool for detecting rare genetic variations, such as drug-resistant mutations. It is expected that molecular diagnoses using digital PCR (dPCR) will be available in clinical practice in the near future; thus, how to efficiently conduct dPCR with human genetic material is a hot topic. Read More

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http://dx.doi.org/10.3791/58199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128215PMC

Tubulo-papillary adrenocortical adenoma in a patient with familial adenomatous polyposis: A morphologic, ultrastructural and molecular study.

Hum Pathol 2018 Aug 30. Epub 2018 Aug 30.

Department of Pathology, the Medical College of Wisconsin, Milawukee, WI. Electronic address:

Patients with Familial Adenomatous Polyposis (FAP) have a higher incidence for developing adrenal neoplasms, most of which are non-functioning with conventional histologic appearance. We report a patient with a history of multiple colon polyps who developed an adrenocortical adenoma with unusual morphology. The tumor showed a tubulo-papillary architecture and plasmacytoid cytomorphology that were distinct from conventional adrenocortical adenomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183033
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http://dx.doi.org/10.1016/j.humpath.2018.08.022DOI Listing
August 2018
9 Reads

Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis.

FASEB J 2019 Feb 29;33(2):1873-1886. Epub 2018 Aug 29.

Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Signal transducer and activator of transcription 3 (Stat3) has been shown to play a role in intestinal regeneration and colitis-associated colon carcinogenesis. However, the role of Stat3 in the Wnt-driven sporadic intestinal tumorigenesis remains poorly understood. We examined the roles of Stat3 in intestinal regeneration and tumorigenesis by organoid culture experiments using Stat3 mouse-derived intestinal epithelial cells in which Stat3 was disrupted. Read More

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http://dx.doi.org/10.1096/fj.201801176RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338624PMC
February 2019
8 Reads

Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity?

Can J Gastroenterol Hepatol 2018 1;2018:2182784. Epub 2018 Aug 1.

Department of Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, Germany.

Background: Portal hypertension is a serious complication of liver cirrhosis.

Objective: To identify relevant endoscopic findings in patients with advanced cirrhosis and consecutive portal hypertension.

Methods: This was a retrospective study of liver transplant candidates who underwent upper gastrointestinal endoscopy between April 2011 and November 2015. Read More

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http://dx.doi.org/10.1155/2018/2182784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093009PMC
February 2019
17 Reads

Protease-activated receptor-1 impedes prostate and intestinal tumor progression in mice.

J Thromb Haemost 2018 Nov 27;16(11):2258-2269. Epub 2018 Sep 27.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Essentials Protease activated receptor-1 (PAR-1) has been proposed to drive cancer progression. Surprisingly, PAR-1 deletion accelerated tumor progression in two distinct experimental settings. PAR-1 deletion was shown to limit the apoptosis of transformed epithelial cells. Read More

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http://dx.doi.org/10.1111/jth.14277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214773PMC
November 2018
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Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer.

Nat Commun 2018 08 27;9(1):3473. Epub 2018 Aug 27.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.

p21-activated kinases (Paks) play an important role in oncogenic signaling pathways and have been considered as potential therapeutic targets in various cancers. Most studies of Pak function employ gene knock-out or knock-down methods, but these approaches result in loss of both enzymatic and scaffolding properties of these proteins, and thus may not reflect the effects of small molecule inhibitors. Here we use a transgenic mouse model in which a specific peptide inhibitor of Group I Paks is conditionally expressed in response to Cre recombinase. Read More

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http://dx.doi.org/10.1038/s41467-018-05935-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110733PMC
August 2018
10 Reads

Elevated expression of p53 in early colon polyps in a pig model of human familial adenomatous polyposis.

J Appl Genet 2018 Nov 25;59(4):485-491. Epub 2018 Aug 25.

Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland.

Familial adenomatous polyposis (FAP) is a hereditary predisposition to formation of colon polyps that can progress to colorectal cancer (CRC). The severity of polyposis varies substantially within families bearing the same germline mutation in the adenomatous polyposis coli (APC) tumour suppressor gene. The progressive step-wise accumulation of genetic events in tumour suppressor genes and oncogenes leads to oncogenic transformation, with driver alterations in the tumour protein p53 (TP53) gene playing a key role in advanced stage CRC. Read More

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http://link.springer.com/10.1007/s13353-018-0461-6
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http://dx.doi.org/10.1007/s13353-018-0461-6DOI Listing
November 2018
13 Reads

Hepatic portal venous gas after colonoscopy: A case report and review.

Int J Surg Case Rep 2018 21;51:54-57. Epub 2018 Jul 21.

Institute of Geriatric Surgery, Università Campus Bio-Medico, Via Alvaro del Portillo 21 - 00128 Rome, Italy.

Introduction: Hepatic portal venous gas (HPVG) is a rare radiological finding in which gas enters the portal venous system and it is associated in case of necrotizing colitis with a mortality of 75%. We report a case of iatrogenic HPVG with a review of literature.

Presentation Of Case: A 41 years old patient underwent total colectomy and ileal pouch- anal anastomosis with derivative ileostomy for a familiar adenomatous polyposis coli in June 2008. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.06.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107896PMC
July 2018
15 Reads

The chemopreventive effect of withaferin A on spontaneous and inflammation-associated colon carcinogenesis models.

Carcinogenesis 2018 Dec;39(12):1537-1547

Department of Urology, University of Louisville, Louisville, KY, USA.

Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal and colon carcinogenesis remain unknown. We investigated the chemopreventive effect of WA on transgenic adenomatous polyposis coli (APCMin/+) mouse and chemically induced azoxymethane/dextran sodium sulfate (AOM/DSS) models of intestinal and colon carcinogenesis. Oral WA administration (4 and 3 mg/kg) inhibited tumor initiation and progression of intestinal polyps formation in APCMin/+ mice and colon carcinogenesis in the AOM/DSS mouse model. Read More

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http://dx.doi.org/10.1093/carcin/bgy109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314334PMC
December 2018