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    Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression.
    Oncogene 2017 May 29. Epub 2017 May 29.
    Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria.
    The canonical WNT signaling pathway is crucial for intestinal stem cell renewal and aberrant WNT signaling is an early event in colorectal cancer (CRC) development. Here, we show for the first time that WNT2 is one of the most significantly induced genes in CRC stroma as compared to normal stroma. The impact of stromal WNT2 on carcinoma formation or progression was not addressed so far. Read More

    Choice of Allograft in Patients Requiring Intestinal Transplantation: A Critical Review.
    Can J Gastroenterol Hepatol 2017 3;2017:1069726. Epub 2017 May 3.
    Intestinal Rehabilitation and Transplantation Program, Recanati/Miller Transplantation Institute, Mount Sinai Medical Center, New York, NY, USA.
    Intestinal transplantation (ITx) is indicated in patients with irreversible intestinal failure (IF) and life-threatening complications related to total parenteral nutrition (TPN). ITx can be classified into three main types. Isolated intestinal transplantation (IITx), that is, transplantation of the jejunoileum, is indicated in patients with preserved liver function. Read More

    Extracolonic cancer risk in Dutch patients with APC (adenomatous polyposis coli)-associated polyposis.
    J Med Genet 2017 May 10. Epub 2017 May 10.
    Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
    Background: Screening of patients with familial adenomatous polyposis (FAP) have led to a substantial reduction in mortality due to colorectal cancer (CRC). Recent guidelines suggest that surveillance of non-intestinal malignancies should also be considered in those patients. However, the value of these surveillance programmes is unknown. Read More

    The different pathogeneses of sporadic adenoma and adenocarcinoma in non-ampullary lesions of the proximal and distal duodenum.
    Oncotarget 2017 Jun;8(25):41078-41090
    Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.
    Non-ampullary duodenal adenoma with activation of Wnt/β-catenin signalling is common in familial adenomatous polyposis (FAP) patients, whereas sporadic non-ampullary adenoma is uncommon. The adenoma-carcinoma sequence similar to colon cancer is associated with duodenal tumors in FAP, but not always in sporadic tumors. We obtained 37 non-ampullary duodenal tumors, including 25 adenomas and 12 adenocarcinomas, were obtained from biopsies and endoscopic resections. Read More

    HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche.
    Nat Commun 2017 Apr 28;8:15008. Epub 2017 Apr 28.
    Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Room 1025, Baltimore, Maryland 21205, USA.
    High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and polyposis in transgenic mice. Here we demonstrate that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and expand the ISC compartment. Read More

    Gastrointestinal mantle cell lymphoma with isolated mass and multiple lymphomatous polyposis: report of two cases.
    Clin J Gastroenterol 2017 Apr 27. Epub 2017 Apr 27.
    Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Uchimaru 19-1, Morioka, 020-8505, Japan.
    We herein report two patients with mantle cell lymphoma (MCL), who had isolated mass and multiple lymphomatous polyposis (MLP) in the gastrointestinal tract. In case 1, esophagogastroduodenoscopy revealed a protruding mass in the duodenum and double-balloon endoscopy disclosed numerous polypoid lesions in the ileum. Case 2 had polyposis in the duodenum and a large mass-forming lesion in the ascending colon. Read More

    Peutz-Jeghers syndrome with intermittent upper intestinal obstruction: A case report and review of the literature.
    Medicine (Baltimore) 2017 Apr;96(17):e6538
    aDepartment of Pediatric Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China bDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
    Rationale: Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic syndrome characterized by a unique type of gastrointestinal hamartomatous polyp associated with oral and anal mucocutaneous pigmentations. Peutz-Jeghers polyps occur most numerously in the small intestine but frequently in the colon and stomach, only a few cases have been reported in the duodenum.

    Patient Concern: A further family history survey discovered 10 out of 14 members of the family (in 4 generations) had mucocutaneous pigmentations, but many of them were living in rural areas where they had no access to specialized medical services, so none were checked with endoscopy for polyps of hamartoma. Read More

    Gastric and duodenal polyps in familial adenomatous polyposis patients: Conventional endoscopy vs virtual chromoendoscopy (fujinon intelligent color enhancement) in dysplasia evaluation.
    World J Clin Oncol 2017 Apr;8(2):168-177
    Gabriele Lami, Andrea Galli, Maria Rosa Biagini, Mirko Tarocchi, Stefano Milani, Simone Polvani, Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139 Florence, Italy.
    Aim: To test the fujinon intelligent color enhancement (FICE) in identifying dysplastic or adenomatous polyps in familial adenomatous polyposis (FAP) patients.

    Methods: Seventy-six consecutive FAP patients, already treated by colectomy and members of sixty-five families, were enrolled. A FICE system for the upper gastro-intestinal tract with an electronic endoscope system and a standard duodenoscope (for side-viewing examination) were used by two expert examiners. Read More

    Association of autoimmune thyroiditis and celiac disease with Juvenile Polyposis due to 10q23.1q23.31 deletion: Potential role of PI3K/Akt pathway dysregulation.
    Eur J Med Genet 2017 Jul 18;60(7):380-384. Epub 2017 Apr 18.
    Department of Biomedical Sciences and Human Oncology, Medical Genetics Unit, Aldo Moro University of Bari, Italy.
    Juvenile Polyposis (JP) is a rare hereditary condition characterized by diffuse hamartomatous gastrointestinal polyposis, associated with a significantly increased risk of neoplastic transformation. Most of the cases are caused by SMAD and BMPR1A mutations, while 10q23 microdeletions, encompassing both PTEN and BMPR1A oncogenes, are extremely rare, typically associated with more aggressive JP, and extraintestinal features overlapping with PTEN Hamartoma Tumor Syndrome. We present the first case of a young female with multiple autoimmune disorders (i. Read More

    HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.
    Cancer Res 2017 May 20;77(9):2424-2438. Epub 2017 Feb 20.
    Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.
    HuR is an RNA-binding protein implicated in immune homeostasis and various cancers, including colorectal cancer. HuR binding to AU-rich elements within the 3' untranslated region of mRNAs encoding oncogenes, growth factors, and various cytokines leads message stability and translation. In this study, we evaluated HuR as a small-molecule target for preventing colorectal cancer in high-risk groups such as those with familial adenomatosis polyposis (FAP) or inflammatory bowel disease (IBD). Read More

    Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia.
    Oncogene 2017 Apr 17. Epub 2017 Apr 17.
    Department of Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
    Overexpression of the transcriptional coregulators C-terminal binding proteins 1 and 2 (CtBP1 and 2) occurs in many human solid tumors and is associated with poor prognosis. CtBP modulates oncogenic gene expression programs and is an emerging drug target, but its oncogenic role is unclear. Consistent with this oncogenic potential, exogenous CtBP2 transformed primary mouse and human cells to anchorage independence similarly to mutant H-Ras. Read More

    A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).
    Elife 2017 Apr 11;6. Epub 2017 Apr 11.
    Functional and Chemical Genomics, Oklahoma Medical Research Foundation, Oklahoma City, United States.
    Elucidating signaling pathways that regulate cellular metabolism is essential for a better understanding of normal development and tumorigenesis. Recent studies have shown that mitochondrial pyruvate carrier 1 (MPC1), a crucial player in pyruvate metabolism, is downregulated in colon adenocarcinomas. Utilizing zebrafish to examine the genetic relationship between MPC1 and Adenomatous polyposis coli (APC), a key tumor suppressor in colorectal cancer, we found that apc controls the levels of mpc1 and that knock down of mpc1 recapitulates phenotypes of impaired apc function including failed intestinal differentiation. Read More

    A Peutz-Jeghers syndrome family associated with sinonasal adenocarcinoma: 28 years follow up report.
    Fam Cancer 2017 Apr 8. Epub 2017 Apr 8.
    Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No.5, Fu-Hsing St. Kuei-Shan, Tao-Yuan, 333, Taiwan, Republic of China.
    Peutz-Jeghers syndrome (PJS) is a rare hereditary disorder characterized by hamartomatous polyps in both of the gastrointestinal tract and mucosal pigmentation. It could increase in risk of intestinal and extra-intestinal neoplasms. We here described three cases of sinonasal polyposis in a PJS family and two developed sinonasal type adenocarcinoma. Read More

    Massive Gastric Juvenile Polyposis: A Clinicopathologic Study Using SMAD4 Immunohistochemistry.
    Am J Clin Pathol 2017 Apr;147(4):390
    From the Department of Pathology, University of Washington School of Medicine, Seattle.
    Objectives: Juvenile polyps involving the stomach are uncommon. Massive gastric juvenile polyposis is even rarer.

    Methods: We describe the clinicopathologic features of nine cases of massive gastric juvenile polyposis. Read More

    Gastrointestinal involvement by mantle cell lymphoma observed by endoscopy: A case report.
    Medicine (Baltimore) 2017 Mar;96(11):e6321
    Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
    Introduction: Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin B-cell lymphoma, accounting for 6% of all non-Hodgkin lymphoma. The typical appearance of intestinal MCL is multiple lymphomatous polyposis, whereas presentation as protruding lesions is uncommon. We herein report the case of a 64-year-old male patient who was admitted to our hospital with epigastric pains. Read More

    A Patient With Desmoid Tumors and Familial FAP Having Frame Shift Mutation of the APC Gene.
    Acta Med Iran 2017 Feb;55(2):134-138
    Department of Medical Genetics, Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
    Desmoids tumors, characterized by monoclonal proliferation of myofibroblasts, could occur in 5-10% of patients with familial adenomatous polyposis (FAP) as an extra-colonic manifestation of the disease. FAP can develop when there is a germ-line mutation in the adenomatous polyposis coli gene. Although mild or attenuated FAP may follow mutations in 5΄ extreme of the gene, it is more likely that 3΄ extreme mutations haveamore severe manifestation of thedisease. Read More

    An unusual haemorrhagic complication of an anastomotic leak and a novel method of controlling the haemorrhage.
    Ann R Coll Surg Engl 2017 Mar;99(3):e116-e119
    Emergency surgical unit, Royal Victoria Hospital, Grosvenor Road, Belfast , UK.
    Introduction Restorative proctocolectomy (RP) is undertaken for patients with familial adenomatous polyposis (FAP) and ulcerative colitis, but is associated with a risk of anastomotic leak. Case history A 20-year-old male with a family history of FAP had a RP with a double-stapled J-pouch and covering loop ileostomy. At ileostomy reversal 21 months later, he presented with significant anal bleeding. Read More

    A novel mutation in the STK11 gene causes heritable Peutz-Jeghers syndrome - a case report.
    BMC Med Genet 2017 Feb 23;18(1):19. Epub 2017 Feb 23.
    Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, No. 74 Zhongshan 2 Road, Guangzhou, 510080, China.
    Background: Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. STK11 has been identified as a causative gene for this disease.

    Case Presentation: Herein we report a Chinese Han kindred with PJS. Read More

    A Review of Sleeve Gastrectomy Specimen Histopathology.
    Am Surg 2016 Nov;82(11):1101-1104
    Memorial University Medical Center, Savannah, Georgia, USA.
    With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. Read More

    Prophylactic vaccination targeting ERBB3 decreases polyp burden in a mouse model of human colorectal cancer.
    Oncoimmunology 2017 7;6(1):e1255395. Epub 2016 Dec 7.
    Department of Veterinary Pathobiology, Department of Molecular and Cellular Medicine, Texas A&M University , College Station, TX, USA.
    Prophylactic vaccination is typically utilized for the prevention of communicable diseases such as measles and influenza but, with the exception of vaccines to prevent cervical cancer, is not widely used as a means of preventing or reducing the incidence of cancer. Here, we utilize a peptide-based immunotherapeutic approach targeting ERBB3, a pseudo-kinase member of the EGFR/ERBB family of receptor tyrosine kinases, as a means of preventing occurrence of colon polyps. Administration of the peptide resulted in a significant decrease in the development of intestinal polyps in C57BL/6J-Apc(Min) mice, a model of familial adenomatous polyposis (FAP). Read More

    Gastrointestinal diseases and their oro-dental manifestations: Part 4: Peutz-Jeghers syndrome.
    Br Dent J 2017 Feb;222(3):214-217
    Department of Gastroenterology &Hepatology, Academic Medical Centre, Amsterdam, the Netherlands.
    Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant inherited disorder, caused by germline mutations in the LKB1 tumour suppressor gene. It is clinically characterised by distinct perioral mucocutaneous pigmentations, gastrointestinal polyposis and an increased cancer risk in adult life. Hamartomatous polyps can develop already in the first decade of life and may cause various complications, including abdominal pain, bleeding, anaemia, and acute intestinal obstruction. Read More

    Case report-malignant transformation in Cronkhite-Canada syndrome polyp.
    Medicine (Baltimore) 2017 Feb;96(6):e6051
    Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Rationale: Cronkhite-Canada syndrome (CCS) is a rare disease, the etiology of CCS is currently unknown. Although CCS is widely accepted as a benign disorder, the malignant potential of the polyps in CCS patients is yet controversial.

    Patient Concerns: A 55-year-old Chinese male was first admitted to Beijing Friendship Hospital with a 3-month history of frequent watery diarrhea (10-15 times/day), loss of taste, and a weight loss of 10 kg in August 2010. Read More

    Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.
    Mol Cancer 2017 Feb 1;16(1):30. Epub 2017 Feb 1.
    Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
    Background: More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically marks tumor stem cells (TSCs) that self-renew and increased the tumor progeny in Apc (Min/+) mice. However, the role of Dclk1 expression and its contribution to regulating pro-survival signaling for tumor progression in Apc mutant cancer is poorly understood. Read More

    E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.
    Proc Natl Acad Sci U S A 2017 Feb 30;114(7):E1148-E1157. Epub 2017 Jan 30.
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada;
    Wnt signaling, named after the secreted proteins that bind to cell surface receptors to activate the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis in many adult tissues. Two particularly important cellular programs orchestrated by Wnt signaling are proliferation and stem cell self-renewal. Constitutive activation of the Wnt pathway resulting from mutation or improper modulation of pathway components contributes to cancer development in various tissues. Read More

    [A Case of Familial Adenomatous Polyposis with a Desmoid Tumor Probably Communicating to the Intestinal Lumen That Was Successfully Treated with Non-Surgical Therapy].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2316-2319
    Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
    A 44-year-old man with familial adenomatous polyposis underwent laparoscopic-assistedtotal proctocolectomy with ilealpouch anal anastomosis(IPAA). Computed tomography conducted 21 months after IPAA demonstrated bilateral hydronephrosis andan intra-abdominal mass with a maximal diameter of 22 cm, leading to a diagnosis of stage IV desmoid disease, according to the classification by Church and associates. Six courses of combination chemotherapy with doxorubicin plus dacarbazine were administered. Read More

    Patient and medical barriers preclude uptake of tamoxifen preventative therapy in women with a strong family history.
    Breast 2017 Apr 18;32:93-97. Epub 2017 Jan 18.
    Breast Tumor Stream, Victorian Comprehensive Cancer Centre, Australia; Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, Australia; Familial Cancer Centre, The Royal Melbourne Hospital, Peter MacCallum Cancer Centre, Australia.
    Aims: To assess the eligibility, uptake and impediments to tamoxifen use in high-risk women attending a risk management clinic due to family history.

    Patients And Methods: All patients with a germline mutation in a cancer predisposing gene or at high genetic risk (based on family history) attending a Breast and Ovarian cancer risk management clinic from February 2014 to May 2015 received both verbal and written evidence-based information on preventive therapy and were recommended to consider endocrine prevention if not contraindicated. Endocrine therapy initiation, use and cessation were captured. Read More

    Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features.
    World J Gastroenterol 2016 Dec;22(48):10523-10531
    Masaki Miyazawa, Mitsuru Matsuda, Masaaki Yano, Yasumasa Hara, Fumitaka Arihara, Yosuke Horita, Koichiro Matsuda, Akito Sakai, Yatsugi Noda, Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama 930-8550, Japan.
    Gastric adenocarcinoma of the fundic gland (chief cell-predominant type, GA-FG-CCP) is a rare variant of well-differentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial elevated shape or a flat shape on macroscopic examination. Read More

    Suppression of intestinal tumorigenesis in Apc mutant mice upon Musashi-1 deletion.
    J Cell Sci 2017 Feb 12;130(4):805-813. Epub 2017 Jan 12.
    Department of Molecular Biosciences, University of Kansas, 7049 Haworth Hall, 1200 Sunnyside Ave., Lawrence, KS 66045, USA
    Therapeutic strategies based on a specific oncogenic target are better justified when elimination of that particular oncogene reduces tumorigenesis in a model organism. One such oncogene, Musashi-1 (Msi-1), regulates translation of target mRNAs and is implicated in promoting tumorigenesis in the colon and other tissues. Msi-1 targets include the tumor suppressor adenomatous polyposis coli (Apc), a Wnt pathway antagonist lost in ∼80% of all colorectal cancers. Read More

    A disturbance of intestinal epithelial cell population and kinetics in APC1638T mice.
    Med Mol Morphol 2017 Jun 9;50(2):94-102. Epub 2017 Jan 9.
    Department of Anatomy, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.
    The adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of APC, we explored APC (1638T/1638T) (APC1638T) mice that express a truncated APC lacking the C-terminal domain. The APC1638T mice were tumor free and exhibited growth retardation. Read More

    Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior.
    Proc Natl Acad Sci U S A 2017 Jan 5;114(4):758-763. Epub 2017 Jan 5.
    Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan;
    The spectrum of genetic mutations differs among cancers in different organs, implying a cellular context-dependent effect for genetic aberrations. However, the extent to which the cellular context affects the consequences of oncogenic mutations remains to be fully elucidated. We reprogrammed colon tumor cells in an Apc(Min/+) (adenomatous polyposis coli) mouse model, in which the loss of the Apc gene plays a critical role in tumor development and subsequently, established reprogrammed tumor cells (RTCs) that exhibit pluripotent stem cell (PSC)-like signatures of gene expression. Read More

    Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.
    Mol Biol Cell 2017 Mar 5;28(5):587-599. Epub 2017 Jan 5.
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208
    Diabetes is linked to an increased risk for colorectal cancer, but the mechanistic underpinnings of this clinically important effect are unclear. Here we describe an interaction between the microtubule motor cytoplasmic dynein, the adenomatous polyposis coli tumor suppressor protein (APC), and glycogen synthase kinase-3β (GSK-3β), which could shed light on this issue. GSK-3β is perhaps best known for glycogen regulation, being inhibited downstream in an insulin-signaling pathway. Read More

    Gardner syndrome associated with multiple osteomas, intestinal polyposis, and epidermoid cysts.
    Imaging Sci Dent 2016 Dec 20;46(4):267-272. Epub 2016 Dec 20.
    Department of Oral and Maxillofacial Radiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju-si, Republic of Korea.
    Gardner syndrome is known as a variant of familial adenomatous polyposis. This syndrome is characterized by multiple intestinal polyposes, osteomas, and epidermoid cysts. In addition, dental abnormalities include an increased frequency of multiple odontomas, as well as supernumerary and impacted teeth. Read More

    Alopecia areata incognita in Cronkhite-Canada syndrome.
    Br J Dermatol 2016 Dec 28. Epub 2016 Dec 28.
    Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, U.K.
    Cronkhite-Canada syndrome is an acquired inflammatory polyposis syndrome in which alopecia, onychomadesis and hyperpigmentation occur concurrently with gastrointestinal symptoms. The pathophysiology of alopecia in Cronkhite-Canada syndrome has not been definitively elucidated. We present evidence for alopecia areata incognita as a possible mechanism of hair loss. Read More

    A small-sample multivariate kernel machine test for microbiome association studies.
    Genet Epidemiol 2017 Apr 26;41(3):210-220. Epub 2016 Dec 26.
    Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
    High-throughput sequencing technologies have enabled large-scale studies of the role of the human microbiome in health conditions and diseases. Microbial community level association test, as a critical step to establish the connection between overall microbiome composition and an outcome of interest, has now been routinely performed in many studies. However, current microbiome association tests all focus on a single outcome. Read More

    A metagenomic study of the preventive effect of Lactobacillus rhamnosus GG on intestinal polyp formation in Apc(Min/+) mice.
    J Appl Microbiol 2017 Mar 30;122(3):770-784. Epub 2017 Jan 30.
    Systems Biology and Bioinformatics Group, School of Biological Sciences, Faculty of Sciences, The University of Hong Kong, Hong Kong, China.
    Aims: To investigate the in vivo effects of Lactobacillus rhamnosus GG (LGG) on intestinal polyp development and the interaction between this single-organism probiotic and the gut microbiota therein.

    Methods And Results: The Apc(Min/+) mouse model was used to study the potential preventive effect of LGG on intestinal polyposis, while shotgun metagenomic sequencing was employed to characterize both taxonomic and functional changes within the gut microbial community. We found that the progression of intestinal polyps in the control group altered the community functional profile remarkably despite small variation in the taxonomic diversity. Read More

    The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse.
    PLoS One 2016 21;11(12):e0167754. Epub 2016 Dec 21.
    Norwegian University of Life Sciences, Department of Food Safety and Infection Biology, Oslo, Norway.
    Background: The novel A/J Min/+ mouse, which is a model for human Familial Adenomatous Polyposis (FAP), develops spontaneously multiple adenocarcinomas in the colon as well as in the small intestine. Agaricus blazei Murill (AbM) is an edible Basidiomycetes mushroom that has been used in traditional medicine against cancer and other diseases. The mushroom contains immunomodulating β-glucans and is shown to have antitumor effects in murine cancer models. Read More

    Sporadic Burkitt Lymphoma Presenting as Intestinal Polyposis in a Child.
    Appl Immunohistochem Mol Morphol 2016 Dec 9. Epub 2016 Dec 9.
    *Department of Pathology ‡Department of Onco-Hematology §Department of Surgery ∥Departement of Garstoenterology Armand Trousseau Hospital Paris, France †Department of Pathology, MD Anderson Cancer Center, Houston, TX.

    Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.
    Biochem Biophys Res Commun 2017 Jan 8;482(4):1296-1303. Epub 2016 Dec 8.
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:
    Ligand-dependent activation of Notch signaling is required to maintain the stem-cell niche of normal intestinal epithelium. However, the precise role of Notch signaling in the maintenance of the intestinal tumor stem cell niche and the importance of the RBPJ-independent non-canonical pathway in intestinal tumors remains unknown. Here we show that Notch signaling was activated in LGR5(+ve) cells of APC-deficient mice intestinal tumors. Read More

    Long QT Syndrome and Duodenal Ampullary Adenoma: A New Association.
    ACG Case Rep J 2016 Aug 23;3(4):e163. Epub 2016 Nov 23.
    Central Florida Gastroenterology and Hepatology, Florida Hospital, Orlando, FL.
    KCNQ1 gene mutation has a well-known association with long QT syndrome (LQTS). However, recent studies suggest that it may be implicated in intestinal neoplasia. We present a 27-year-old Hispanic man with a known history of LQTS secondary to KCNQ1 mutation, who presented with painless jaundice. Read More

    Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota.
    Int J Mol Sci 2016 Dec 2;17(12). Epub 2016 Dec 2.
    Department of Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL 60612, USA.
    Background: Colorectal cancer (CRC) is associated with the modern lifestyle. Chronic alcohol consumption-a frequent habit of majority of modern societies-increases the risk of CRC. Our group showed that chronic alcohol consumption increases polyposis in a mouse mode of CRC. Read More

    Steroid Responsive Mononeuritis Multiplex in the Cronkhite-Canada Syndrome.
    Front Neurol 2016 17;7:207. Epub 2016 Nov 17.
    Department of Gastroenterology and Hepatology, Singapore General Hospital , Singapore.
    The Cronkhite-Canada syndrome (CCS) is a rare disorder of unknown origin characterized by generalized gastrointestinal polyposis, alopecia, hyperpigmentation, and onychodystrophy. We report a case of CCS with concomitant presentation of mononeuritis multiplex. The electrophysiological findings and steroid responsiveness suggests presence of an autoimmune mechanism. Read More

    Genetic predisposition to colorectal cancer: Implications for treatment and prevention.
    Semin Oncol 2016 Oct 1;43(5):536-542. Epub 2016 Sep 1.
    Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
    Colorectal cancer (CRC) is the third most common cancer diagnosed in men and women and approximately 5% of cases are associated with identifiable germline mutations associated with hereditary cancer syndromes. Lifetime risks for CRC can approach 50%-80% for mutation carriers in the absence of endoscopic and/or surgical intervention, and early identification of at-risk individuals can guide clinical interventions for cancer prevention and treatment. Personal and family history and molecular phenotype of CRC tumors are used in determining which patients should be referred for clinical genetic evaluation. Read More

    Cronkhite Canada syndrome complicated by pulmonary embolism-A case report.
    Int J Surg Case Rep 2017 17;30:17-22. Epub 2016 Nov 17.
    Dept. Of Surgery, Aditya Birla Memorial Hospital, Pune, India. Electronic address:
    Introduction: Cronkhite Canada Syndrome (CCS) is a rare syndrome, described in 1955 by Americans, Leonard Wolsey Cronkhite and Wilma Jeanne Canada in the New England Journal of Medicine [1]. About 450 cases have been reported. Complications, like malignant transformation, unprovoked thromboembolism is known. Read More

    Inherited Variants in Wnt Pathway Genes Influence Outcomes of Prostate Cancer Patients Receiving Androgen Deprivation Therapy.
    Int J Mol Sci 2016 Nov 26;17(12). Epub 2016 Nov 26.
    Department of Pharmacy, China Medical University, Taichung 404, Taiwan.
    Aberrant Wnt signaling has been associated with many types of cancer. However, the association of inherited Wnt pathway variants with clinical outcomes in prostate cancer patients receiving androgen deprivation therapy (ADT) has not been determined. Here, we comprehensively studied the contribution of common single nucleotide polymorphisms (SNPs) in Wnt pathway genes to the clinical outcomes of 465 advanced prostate cancer patients treated with ADT. Read More

    Intravenous Vitamin C Administered as Adjunctive Therapy for Recurrent Acute Respiratory Distress Syndrome.
    Case Rep Crit Care 2016 7;2016:8560871. Epub 2016 Nov 7.
    Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
    This case report summarizes the first use of intravenous vitamin C employed as an adjunctive interventional agent in the therapy of recurrent acute respiratory distress syndrome (ARDS). The two episodes of ARDS occurred in a young female patient with Cronkhite-Canada syndrome, a rare, sporadically occurring, noninherited disorder that is characterized by extensive gastrointestinal polyposis and malabsorption. Prior to the episodes of sepsis, the patient was receiving nutrition via chronic hyperalimentation administered through a long-standing central venous catheter. Read More

    Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21.
    Gastroenterology 2017 Mar 19;152(4):851-866.e24. Epub 2016 Nov 19.
    Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:
    Background & Aims: Nearly 20% of the global cancer burden can be linked to infectious agents. Fusobacterium nucleatum promotes tumor formation by epithelial cells via unclear mechanisms. We aimed to identify microRNAs (miRNAs) induced by F nucleatum and evaluate their ability to promote colorectal carcinogenesis in mice. Read More

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