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    Association of autoimmune thyroiditis and celiac disease with Juvenile Polyposis due to 10q23.1q23.31 deletion: Potential role of PI3K/Akt pathway dysregulation.
    Eur J Med Genet 2017 Apr 18. Epub 2017 Apr 18.
    Department of Biomedical Sciences and Human Oncology, Medical Genetics Unit, Aldo Moro University of Bari, Italy.
    Juvenile Polyposis (JP) is a rare hereditary condition characterized by diffuse hamartomatous gastrointestinal polyposis, associated with a significantly increased risk of neoplastic transformation. Most of the cases are caused by SMAD and BMPR1A mutations, while 10q23 microdeletions, encompassing both PTEN and BMPR1A oncogenes, are extremely rare, typically associated with more aggressive JP, and extraintestinal features overlapping with PTEN Hamartoma Tumor Syndrome. We present the first case of a young female with multiple autoimmune disorders (i. Read More

    HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.
    Cancer Res 2017 Feb 20. Epub 2017 Feb 20.
    Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.
    HuR is an RNA-binding protein implicated in immune homeostasis and various cancers, including colorectal cancer. HuR binding to AU-rich elements within the 3' untranslated region of mRNAs encoding oncogenes, growth factors, and various cytokines leads message stability and translation. In this study, we evaluated HuR as a small-molecule target for preventing colorectal cancer in high-risk groups such as those with familial adenomatosis polyposis (FAP) or inflammatory bowel disease (IBD). Read More

    Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia.
    Oncogene 2017 Apr 17. Epub 2017 Apr 17.
    Department of Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
    Overexpression of the transcriptional coregulators C-terminal binding proteins 1 and 2 (CtBP1 and 2) occurs in many human solid tumors and is associated with poor prognosis. CtBP modulates oncogenic gene expression programs and is an emerging drug target, but its oncogenic role is unclear. Consistent with this oncogenic potential, exogenous CtBP2 transformed primary mouse and human cells to anchorage independence similarly to mutant H-Ras. Read More

    A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).
    Elife 2017 Apr 11;6. Epub 2017 Apr 11.
    Functional and Chemical Genomics, Oklahoma Medical Research Foundation, Oklahoma City, United States.
    Elucidating signaling pathways that regulate cellular metabolism is essential for a better understanding of normal development and tumorigenesis. Recent studies have shown that mitochondrial pyruvate carrier 1 (MPC1), a crucial player in pyruvate metabolism, is downregulated in colon adenocarcinomas. Utilizing zebrafish to examine the genetic relationship between MPC1 and Adenomatous polyposis coli (APC), a key tumor suppressor in colorectal cancer, we found that apc controls the levels of mpc1 and that knock down of mpc1 recapitulates phenotypes of impaired apc function including failed intestinal differentiation. Read More

    A Peutz-Jeghers syndrome family associated with sinonasal adenocarcinoma: 28 years follow up report.
    Fam Cancer 2017 Apr 8. Epub 2017 Apr 8.
    Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No.5, Fu-Hsing St. Kuei-Shan, Tao-Yuan, 333, Taiwan, Republic of China.
    Peutz-Jeghers syndrome (PJS) is a rare hereditary disorder characterized by hamartomatous polyps in both of the gastrointestinal tract and mucosal pigmentation. It could increase in risk of intestinal and extra-intestinal neoplasms. We here described three cases of sinonasal polyposis in a PJS family and two developed sinonasal type adenocarcinoma. Read More

    Gastrointestinal involvement by mantle cell lymphoma observed by endoscopy: A case report.
    Medicine (Baltimore) 2017 Mar;96(11):e6321
    Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
    Introduction: Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin B-cell lymphoma, accounting for 6% of all non-Hodgkin lymphoma. The typical appearance of intestinal MCL is multiple lymphomatous polyposis, whereas presentation as protruding lesions is uncommon. We herein report the case of a 64-year-old male patient who was admitted to our hospital with epigastric pains. Read More

    An unusual haemorrhagic complication of an anastomotic leak and a novel method of controlling the haemorrhage.
    Ann R Coll Surg Engl 2017 Mar;99(3):e116-e119
    Emergency surgical unit, Royal Victoria Hospital, Grosvenor Road, Belfast , UK.
    Introduction Restorative proctocolectomy (RP) is undertaken for patients with familial adenomatous polyposis (FAP) and ulcerative colitis, but is associated with a risk of anastomotic leak. Case history A 20-year-old male with a family history of FAP had a RP with a double-stapled J-pouch and covering loop ileostomy. At ileostomy reversal 21 months later, he presented with significant anal bleeding. Read More

    A Review of Sleeve Gastrectomy Specimen Histopathology.
    Am Surg 2016 Nov;82(11):1101-1104
    Memorial University Medical Center, Savannah, Georgia, USA.
    With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. Read More

    Prophylactic vaccination targeting ERBB3 decreases polyp burden in a mouse model of human colorectal cancer.
    Oncoimmunology 2017 7;6(1):e1255395. Epub 2016 Dec 7.
    Department of Veterinary Pathobiology, Department of Molecular and Cellular Medicine, Texas A&M University , College Station, TX, USA.
    Prophylactic vaccination is typically utilized for the prevention of communicable diseases such as measles and influenza but, with the exception of vaccines to prevent cervical cancer, is not widely used as a means of preventing or reducing the incidence of cancer. Here, we utilize a peptide-based immunotherapeutic approach targeting ERBB3, a pseudo-kinase member of the EGFR/ERBB family of receptor tyrosine kinases, as a means of preventing occurrence of colon polyps. Administration of the peptide resulted in a significant decrease in the development of intestinal polyps in C57BL/6J-Apc(Min) mice, a model of familial adenomatous polyposis (FAP). Read More

    Gastrointestinal diseases and their oro-dental manifestations: Part 4: Peutz-Jeghers syndrome.
    Br Dent J 2017 Feb;222(3):214-217
    Department of Gastroenterology &Hepatology, Academic Medical Centre, Amsterdam, the Netherlands.
    Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant inherited disorder, caused by germline mutations in the LKB1 tumour suppressor gene. It is clinically characterised by distinct perioral mucocutaneous pigmentations, gastrointestinal polyposis and an increased cancer risk in adult life. Hamartomatous polyps can develop already in the first decade of life and may cause various complications, including abdominal pain, bleeding, anaemia, and acute intestinal obstruction. Read More

    Case report-malignant transformation in Cronkhite-Canada syndrome polyp.
    Medicine (Baltimore) 2017 Feb;96(6):e6051
    Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Rationale: Cronkhite-Canada syndrome (CCS) is a rare disease, the etiology of CCS is currently unknown. Although CCS is widely accepted as a benign disorder, the malignant potential of the polyps in CCS patients is yet controversial.

    Patient Concerns: A 55-year-old Chinese male was first admitted to Beijing Friendship Hospital with a 3-month history of frequent watery diarrhea (10-15 times/day), loss of taste, and a weight loss of 10 kg in August 2010. Read More

    Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.
    Mol Cancer 2017 Feb 1;16(1):30. Epub 2017 Feb 1.
    Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
    Background: More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically marks tumor stem cells (TSCs) that self-renew and increased the tumor progeny in Apc (Min/+) mice. However, the role of Dclk1 expression and its contribution to regulating pro-survival signaling for tumor progression in Apc mutant cancer is poorly understood. Read More

    E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.
    Proc Natl Acad Sci U S A 2017 Feb 30;114(7):E1148-E1157. Epub 2017 Jan 30.
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada;
    Wnt signaling, named after the secreted proteins that bind to cell surface receptors to activate the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis in many adult tissues. Two particularly important cellular programs orchestrated by Wnt signaling are proliferation and stem cell self-renewal. Constitutive activation of the Wnt pathway resulting from mutation or improper modulation of pathway components contributes to cancer development in various tissues. Read More

    [A Case of Familial Adenomatous Polyposis with a Desmoid Tumor Probably Communicating to the Intestinal Lumen That Was Successfully Treated with Non-Surgical Therapy].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2316-2319
    Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
    A 44-year-old man with familial adenomatous polyposis underwent laparoscopic-assistedtotal proctocolectomy with ilealpouch anal anastomosis(IPAA). Computed tomography conducted 21 months after IPAA demonstrated bilateral hydronephrosis andan intra-abdominal mass with a maximal diameter of 22 cm, leading to a diagnosis of stage IV desmoid disease, according to the classification by Church and associates. Six courses of combination chemotherapy with doxorubicin plus dacarbazine were administered. Read More

    Patient and medical barriers preclude uptake of tamoxifen preventative therapy in women with a strong family history.
    Breast 2017 Apr 18;32:93-97. Epub 2017 Jan 18.
    Breast Tumor Stream, Victorian Comprehensive Cancer Centre, Australia; Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, Australia; Familial Cancer Centre, The Royal Melbourne Hospital, Peter MacCallum Cancer Centre, Australia.
    Aims: To assess the eligibility, uptake and impediments to tamoxifen use in high-risk women attending a risk management clinic due to family history.

    Patients And Methods: All patients with a germline mutation in a cancer predisposing gene or at high genetic risk (based on family history) attending a Breast and Ovarian cancer risk management clinic from February 2014 to May 2015 received both verbal and written evidence-based information on preventive therapy and were recommended to consider endocrine prevention if not contraindicated. Endocrine therapy initiation, use and cessation were captured. Read More

    Suppression of intestinal tumorigenesis in Apc mutant mice upon Musashi-1 deletion.
    J Cell Sci 2017 Feb 12;130(4):805-813. Epub 2017 Jan 12.
    Department of Molecular Biosciences, University of Kansas, 7049 Haworth Hall, 1200 Sunnyside Ave., Lawrence, KS 66045, USA
    Therapeutic strategies based on a specific oncogenic target are better justified when elimination of that particular oncogene reduces tumorigenesis in a model organism. One such oncogene, Musashi-1 (Msi-1), regulates translation of target mRNAs and is implicated in promoting tumorigenesis in the colon and other tissues. Msi-1 targets include the tumor suppressor adenomatous polyposis coli (Apc), a Wnt pathway antagonist lost in ∼80% of all colorectal cancers. Read More

    A disturbance of intestinal epithelial cell population and kinetics in APC1638T mice.
    Med Mol Morphol 2017 Jan 9. Epub 2017 Jan 9.
    Department of Anatomy, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.
    The adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of APC, we explored APC (1638T/1638T) (APC1638T) mice that express a truncated APC lacking the C-terminal domain. The APC1638T mice were tumor free and exhibited growth retardation. Read More

    Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior.
    Proc Natl Acad Sci U S A 2017 Jan 5;114(4):758-763. Epub 2017 Jan 5.
    Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan;
    The spectrum of genetic mutations differs among cancers in different organs, implying a cellular context-dependent effect for genetic aberrations. However, the extent to which the cellular context affects the consequences of oncogenic mutations remains to be fully elucidated. We reprogrammed colon tumor cells in an Apc(Min/+) (adenomatous polyposis coli) mouse model, in which the loss of the Apc gene plays a critical role in tumor development and subsequently, established reprogrammed tumor cells (RTCs) that exhibit pluripotent stem cell (PSC)-like signatures of gene expression. Read More

    Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.
    Mol Biol Cell 2017 Mar 5;28(5):587-599. Epub 2017 Jan 5.
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208
    Diabetes is linked to an increased risk for colorectal cancer, but the mechanistic underpinnings of this clinically important effect are unclear. Here we describe an interaction between the microtubule motor cytoplasmic dynein, the adenomatous polyposis coli tumor suppressor protein (APC), and glycogen synthase kinase-3β (GSK-3β), which could shed light on this issue. GSK-3β is perhaps best known for glycogen regulation, being inhibited downstream in an insulin-signaling pathway. Read More

    Gardner syndrome associated with multiple osteomas, intestinal polyposis, and epidermoid cysts.
    Imaging Sci Dent 2016 Dec 20;46(4):267-272. Epub 2016 Dec 20.
    Department of Oral and Maxillofacial Radiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju-si, Republic of Korea.
    Gardner syndrome is known as a variant of familial adenomatous polyposis. This syndrome is characterized by multiple intestinal polyposes, osteomas, and epidermoid cysts. In addition, dental abnormalities include an increased frequency of multiple odontomas, as well as supernumerary and impacted teeth. Read More

    Alopecia areata incognita in Cronkhite-Canada Syndrome.
    Br J Dermatol 2016 Dec 28. Epub 2016 Dec 28.
    Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
    Cronkhite-Canada syndrome is an acquired inflammatory polyposis syndrome in which alopecia, onychomadesis and hyperpigmentation occur concurrently with gastrointestinal symptoms. The pathophysiology of alopecia in Cronkhite-Canada Syndrome has not been definitively elucidated and we present evidence for alopecia incognita as a possible mechanism of hair loss. This article is protected by copyright. Read More

    A metagenomic study of the preventive effect of Lactobacillus rhamnosus GG on intestinal polyp formation in Apc(Min/+) mice.
    J Appl Microbiol 2017 Mar 30;122(3):770-784. Epub 2017 Jan 30.
    Systems Biology and Bioinformatics Group, School of Biological Sciences, Faculty of Sciences, The University of Hong Kong, Hong Kong, China.
    Aims: To investigate the in vivo effects of Lactobacillus rhamnosus GG (LGG) on intestinal polyp development and the interaction between this single-organism probiotic and the gut microbiota therein.

    Methods And Results: The Apc(Min/+) mouse model was used to study the potential preventive effect of LGG on intestinal polyposis, while shotgun metagenomic sequencing was employed to characterize both taxonomic and functional changes within the gut microbial community. We found that the progression of intestinal polyps in the control group altered the community functional profile remarkably despite small variation in the taxonomic diversity. Read More

    The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse.
    PLoS One 2016 21;11(12):e0167754. Epub 2016 Dec 21.
    Norwegian University of Life Sciences, Department of Food Safety and Infection Biology, Oslo, Norway.
    Background: The novel A/J Min/+ mouse, which is a model for human Familial Adenomatous Polyposis (FAP), develops spontaneously multiple adenocarcinomas in the colon as well as in the small intestine. Agaricus blazei Murill (AbM) is an edible Basidiomycetes mushroom that has been used in traditional medicine against cancer and other diseases. The mushroom contains immunomodulating β-glucans and is shown to have antitumor effects in murine cancer models. Read More

    Sporadic Burkitt Lymphoma Presenting as Intestinal Polyposis in a Child.
    Appl Immunohistochem Mol Morphol 2016 Dec 9. Epub 2016 Dec 9.
    *Department of Pathology ‡Department of Onco-Hematology §Department of Surgery ∥Departement of Garstoenterology Armand Trousseau Hospital Paris, France †Department of Pathology, MD Anderson Cancer Center, Houston, TX.

    Long QT Syndrome and Duodenal Ampullary Adenoma: A New Association.
    ACG Case Rep J 2016 Aug 23;3(4):e163. Epub 2016 Nov 23.
    Central Florida Gastroenterology and Hepatology, Florida Hospital, Orlando, FL.
    KCNQ1 gene mutation has a well-known association with long QT syndrome (LQTS). However, recent studies suggest that it may be implicated in intestinal neoplasia. We present a 27-year-old Hispanic man with a known history of LQTS secondary to KCNQ1 mutation, who presented with painless jaundice. Read More

    Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota.
    Int J Mol Sci 2016 Dec 2;17(12). Epub 2016 Dec 2.
    Department of Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL 60612, USA.
    Background: Colorectal cancer (CRC) is associated with the modern lifestyle. Chronic alcohol consumption-a frequent habit of majority of modern societies-increases the risk of CRC. Our group showed that chronic alcohol consumption increases polyposis in a mouse mode of CRC. Read More

    Steroid Responsive Mononeuritis Multiplex in the Cronkhite-Canada Syndrome.
    Front Neurol 2016 17;7:207. Epub 2016 Nov 17.
    Department of Gastroenterology and Hepatology, Singapore General Hospital , Singapore.
    The Cronkhite-Canada syndrome (CCS) is a rare disorder of unknown origin characterized by generalized gastrointestinal polyposis, alopecia, hyperpigmentation, and onychodystrophy. We report a case of CCS with concomitant presentation of mononeuritis multiplex. The electrophysiological findings and steroid responsiveness suggests presence of an autoimmune mechanism. Read More

    Cronkhite Canada syndrome complicated by pulmonary embolism-A case report.
    Int J Surg Case Rep 2017 17;30:17-22. Epub 2016 Nov 17.
    Dept. Of Surgery, Aditya Birla Memorial Hospital, Pune, India. Electronic address:
    Introduction: Cronkhite Canada Syndrome (CCS) is a rare syndrome, described in 1955 by Americans, Leonard Wolsey Cronkhite and Wilma Jeanne Canada in the New England Journal of Medicine [1]. About 450 cases have been reported. Complications, like malignant transformation, unprovoked thromboembolism is known. Read More

    Intravenous Vitamin C Administered as Adjunctive Therapy for Recurrent Acute Respiratory Distress Syndrome.
    Case Rep Crit Care 2016 7;2016:8560871. Epub 2016 Nov 7.
    Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
    This case report summarizes the first use of intravenous vitamin C employed as an adjunctive interventional agent in the therapy of recurrent acute respiratory distress syndrome (ARDS). The two episodes of ARDS occurred in a young female patient with Cronkhite-Canada syndrome, a rare, sporadically occurring, noninherited disorder that is characterized by extensive gastrointestinal polyposis and malabsorption. Prior to the episodes of sepsis, the patient was receiving nutrition via chronic hyperalimentation administered through a long-standing central venous catheter. Read More

    Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21.
    Gastroenterology 2017 Mar 19;152(4):851-866.e24. Epub 2016 Nov 19.
    Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:
    Background & Aims: Nearly 20% of the global cancer burden can be linked to infectious agents. Fusobacterium nucleatum promotes tumor formation by epithelial cells via unclear mechanisms. We aimed to identify microRNAs (miRNAs) induced by F nucleatum and evaluate their ability to promote colorectal carcinogenesis in mice. Read More

    Management strategies in Lynch syndrome and familial adenomatous polyposis: a national healthcare survey in Japan.
    Cancer Sci 2017 Feb;108(2):243-249
    Tokyo Medical and Dental University, Tokyo, Japan.
    Lynch syndrome (LS) and familial adenomatous polyposis (FAP) are major sources of hereditary colorectal cancer (CRC) and are associated with other malignancies. There is some heterogeneity in management strategies in Japan. We undertook a survey of management of hereditary CRC in hospitals that are members of the Japan Society of Colorectal Cancer Research. Read More

    Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed Apc(Min) mice.
    Nutr Res 2016 Nov 15;36(11):1285-1297. Epub 2016 Oct 15.
    Department of Food and Environmental Sciences, Division of Nutrition, University of Helsinki, PO Box 66, Helsinki FIN-00014, Finland. Electronic address:
    We showed previously that ellagitannin-rich cloudberries and anthocyanin-rich bilberries reduce the number of intestinal adenomas in multiple intestinal neoplasia/+ (Apc(Min)) mice. We also found that cloudberries decreased the size of adenomas, whereas bilberries increased it. Here we hypothesized that the difference in adenoma growth could be explained by dissimilar effects of the berries on intestinal immune responses and gut microbiota, potentially driven by the distinct polyphenol compositions of the 2 berries. Read More

    Does routine colonoscopy help diagnose familial adenomatous polyposis in patients presenting with desmoid tumors but no gastrointestinal symptoms?
    Int J Colorectal Dis 2017 Jan 14;32(1):151-154. Epub 2016 Nov 14.
    Department of Surgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, 13620, South Korea.
    Purpose: Desmoid tumor (DT) is a rare myofibroblastic proliferative neoplasm, but can occur in up to 26% of patients with familial adenomatous polyposis (FAP). Therefore, DT may be an extraintestinal manifestation of FAP that precedes the development of advanced malignancies. The aim of this study was to identify the incidence of polyps in DT patients and investigate value of colonoscopy for diagnosis of FAP in DT patients without gastrointestinal symptoms. Read More

    A case series of intestinal adenomatous polyposis of unidentified etiology; a late effect of irradiation?
    BMC Cancer 2016 Nov 8;16(1):862. Epub 2016 Nov 8.
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.
    Background: In a large number of patients with multiple gastrointestinal adenomatous polyps, no causal germline mutation can be found. Non-genetic factors may contribute to the development of adenomatous polyps in these unexplained polyposis patients. In the development of gastrointestinal cancer, prior exposure to abdominal radiotherapy has been identified as such a factor, as it increases the gastrointestinal cancer risk in cancer survivors. Read More

    Distinct Patterns of Somatic Mosaicism in the APC Gene in Neoplasms From Patients With Unexplained Adenomatous Polyposis.
    Gastroenterology 2017 Feb 2;152(3):546-549.e3. Epub 2016 Nov 2.
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands. Electronic address:
    We investigated the presence and patterns of mosaicism in the APC gene in patients with colon neoplasms not associated with any other genetic variants; we performed deep sequence analysis of APC in at least 2 adenomas or carcinomas per patient. We identified mosaic variants in APC in adenomas from 9 of the 18 patients with 21 to approximately 100 adenomas. Mosaic variants of APC were variably detected in leukocyte DNA and/or non-neoplastic intestinal mucosa of these patients. Read More

    The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.
    Oncotarget 2016 Dec;7(49):80612-80632
    Tumor Biology and Signal Transduction, Dept. of Hematology and Medical Oncology, Georg-August-University Göttingen, Germany.
    Pygo2 acts as a co-activator of Wnt signaling in a nuclear complex with ß-catenin/BCL9/BCL9-2 to increase target gene transcription. Previous studies showed that Pygo2 is upregulated in murine intestinal tumors and human colon cancer, but is apparently dispensable for normal intestinal homeostasis. Here, we have evaluated the in vivo role of Pygo2 during intestinal tumorigenesis using Pygo2 deficient mice. Read More

    Retroileal colorectal anastomosis after extended left colectomy: application for laparoscopic surgery.
    Surg Today 2016 Dec 18;46(12):1476-1478. Epub 2016 Feb 18.
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ku, Kumamoto, 860-8556, Japan.
    Tension-free anastomosis is often difficult to achieve after extended left hemicolectomy because the residual colon is too short to reach the rectal stump. Retroileal colorectal anastomosis is very simple and useful for obtaining tension-free anastomosis. We first applied this technique to laparoscopic operations. Read More

    Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice.
    Cancer Immunol Res 2016 Nov 16;4(11):917-926. Epub 2016 Sep 16.
    Department of Pathology, Stanford University School of Medicine (Blood Center), Palo Alto, California.
    Chronic intestinal inflammation accompanies familial adenomatous polyposis (FAP) and is a major risk factor for colorectal cancer in patients with this disease, but the cause of such inflammation is unknown. Because retinoic acid (RA) plays a critical role in maintaining immune homeostasis in the intestine, we hypothesized that altered RA metabolism contributes to inflammation and tumorigenesis in FAP. To assess this hypothesis, we analyzed RA metabolism in the intestines of patients with FAP as well as APC(Min/+) mice, a model that recapitulates FAP in most respects. Read More

    Altered T-Cell Balance in Lymphoid Organs of a Mouse Model of Colorectal Cancer.
    J Histochem Cytochem 2016 Dec 20;64(12):753-767. Epub 2016 Oct 20.
    Department of Biological, Physical, and Earth Sciences, Limestone College, Gaffney, South Carolina (SMT)
    The adenomatous polyposis coli (APC) gene is a known tumor suppressor gene, and mice with mutations in Apc (Apc(Min/+)) spontaneously form multiple intestinal neoplasms. In this model of human colorectal cancer (CRC), it has been reported that CD4(+) T-cell-derived interleukin 17 (IL-17) promotes intestinal tumor development, but it is not known if the Apc mutation actually directly alters T-cell function and subsequently tumor immunosurveillance. To investigate the Apc(Min/+) mutation on T-cell function, flow cytometric, histochemical, and immunofluorescent studies on both wild-type (Apc(+/+)) and Apc(Min/+) mice were performed. Read More

    [Desmoid tumors in an adolescent girl with familial adenomatous polyposis].
    Arch Pediatr 2016 Nov 28;23(11):1141-1145. Epub 2016 Sep 28.
    Service de pédiatrie, centre hospitalier Jacques-Monod, 29, avenue Pierre-Mendès, 76600 Le Havre, France. Electronic address:
    Desmoid tumors (DT) are rare and nonmetastasizing fibroblastic neoplasms, characterized by local invasiveness. They occur sporadically or arise in the context of familial adenomatous polyposis (FAP; 5-10% of cases). Most cases develop sporadically in young adults, but some cases also occur in children. Read More

    Prior Bariatric Surgery Is Linked to Improved Colorectal Cancer Surgery Outcomes and Costs: A Propensity-Matched Analysis.
    Obes Surg 2017 Apr;27(4):1047-1055
    Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA.
    Background: Morbid obesity is associated with worse colorectal cancer (CRC) perioperative outcomes. The impact of bariatric surgery on these outcomes is unknown.

    Methods: The National Inpatient Sample Database (2006-2012) was used to identify adults with prior bariatric surgery (divided into BMI ≤35 kg/m(2) and BMI >35 kg/m(2)) or morbid obesity that underwent CRC surgery. Read More

    A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis.
    Oncotarget 2016 Dec;7(49):80508-80520
    Georgetown-Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University School of Medicine, Washington, DC, United States of America.
    Vitamin D is implicated in the etiology of cancers of the gastrointestinal tract, usually characterized by alteration in the APC/β-catenin/TCF tumor suppressor pathway. The vitamin D receptor (VDR) is also implicated in cardiovascular and skin diseases as well as in immunity. Activated VDR can indirectly alter β-catenin nuclear localization and directly suppress β-catenin/TCF mediated transcriptional activity. Read More

    Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APC(min/+) Mouse Models of Experimental Colon Cancer.
    Phytother Res 2017 Jan 12;31(1):90-99. Epub 2016 Oct 12.
    Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USA.
    Chemopreventative properties of traditional medicines and underlying mechanisms of action are incompletely investigated. This study demonstrates that dietary daikenchuto (TU-100), comprised of ginger, ginseng, and Japanese pepper effectively suppresses intestinal tumor development and progression in the azoxymethane (AOM) and APC(min/+) mouse models. For the AOM model, TU-100 was provided after the first of six biweekly AOM injections. Read More

    Effectiveness of cyclosporine as a treatment for steroid-resistant Cronkhite-Canada syndrome; two case reports.
    BMC Gastroenterol 2016 Oct 6;16(1):123. Epub 2016 Oct 6.
    Division of Gastroenterology and Hepatology, Digestive Disease Center, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
    Background: Cronkhite-Canada syndrome (CCS) is a rare non-inherited disorder, characterized by gastrointestinal polyposis and ectodermal changes. The pathophysiology remains unclear. Treatment with corticosteroids is considered the mainstay treatment because of its high efficacy. Read More

    Colorectal Adenomatous Polyposis: Heterogeneity of Susceptibility Gene Mutations and Phenotypes in a Cohort of Italian Patients.
    Genet Test Mol Biomarkers 2016 Dec 5;20(12):777-785. Epub 2016 Oct 5.
    1 Department of Biology and Biotechnology, University of Pavia , Pavia, Italy .
    Aims: Colorectal adenomatous polyposis entailing cancer predisposition is caused by constitutional mutations in different genes. APC is associated with the familial adenomatous polyposis (FAP/AFAP) and MUTYH with the MUTYH-associated polyposis (MAP), while POLE and POLD1 mutations cause the polymerase proofreading-associated polyposis (PPAP).

    Methods: We screened for mutations in patients with multiple adenomas/FAP: 121 patients were analyzed for APC and MUTYH mutations, and 36 patients were also evaluated for POLE and POLD1 gene mutations. Read More

    Fecal Metabolome in Hmga1 Transgenic Mice with Polyposis: Evidence for Potential Screen for Early Detection of Precursor Lesions in Colorectal Cancer.
    J Proteome Res 2016 Dec 4;15(12):4176-4187. Epub 2016 Nov 4.
    Department of Chemistry, ‡School of Molecular Biosciences, and §Institute of Biological Chemistry, Washington State University , Pullman, Washington 99164, United States.
    Because colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, more accessible screening tests are urgently needed to identify early stage lesions. We hypothesized that highly sensitive, metabolic profile analysis of stool samples will identify metabolites associated with early stage lesions and could serve as a noninvasive screening test. We therefore applied traveling wave ion mobility mass spectrometry (TWIMMS) coupled with ultraperformance liquid chromatography (UPLC) to investigate metabolic aberrations in stool samples in a transgenic model of premalignant polyposis aberrantly expressing the gene encoding the high mobility group A (Hmga1) chromatin remodeling protein. Read More

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