294 results match your criteria Cronkhite-Canada Syndrome
Intest Res 2018 Dec 14. Epub 2018 Dec 14.
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):753-757
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
To analyze the clinical and pathological features of Cronkhite-Canada syndrome (CCS), and to investigate the significance of IgG4 positive plasma cell infiltration. Clinical presentations, endoscopic appearances and morphological features of 18 patients diagnosed with CCS at Peking Union Medical College Hospital during 2000-2016 were included in the study.There were 11 male and 7 female patients. Read More
J Gastroenterol Hepatol 2018 Dec 1;33(12):1937. Epub 2018 Aug 1.
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Case Rep Med 2018 2;2018:9409732. Epub 2018 Jul 2.
Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada.
Cronkhite-Canada syndrome (CCS) is a rare, nonfamilial syndrome that occurs in the sixth to seventh decades of life. It is characterized by acquired gastrointestinal polyposis with an associated ectodermal triad, including alopecia, onchodystrophy, and hyperpigmentation. CCS is characteristically a progressive disease, with a high mortality rate despite medical interventions. Read More
Intern Med 2018 Nov 6;57(21):3079-3085. Epub 2018 Jun 6.
Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.
Cronkhite-Canada syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis, chronic diarrhea, ectodermal dysplasia, skin hyperpigmentation, hair loss and nail atrophy. Although the efficacy of corticosteroid and immunomodulatory agents has been demonstrated, no standard therapy regimen has been established, and the prognosis of CCS is still poor due to various complications. We here in report a CCS patient complicated with severe sepsis and disseminated intravascular coagulation who was successfully treated by combined modality therapies, including recombinant human soluble thrombomodulin. Read More
Oncol Lett 2018 Jun 2;15(6):8447-8453. Epub 2018 Apr 2.
Department of Gastroenterology, Hunan Key Laboratory of Non-Resolving Inflammation and Cancer, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China.
Cronkhite-Canada syndrome (CCS) is a rare non-inherited condition characterized by gastrointestinal (GI) hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, weight loss and diarrhea. The etiology is most likely autoimmune and diagnosis is based on patient history, physical examination, endoscopic findings of GI polyposis and histology. The disease is very rare; thus far more than 500 cases of CCS have been reported globally. Read More
Case Rep Gastroenterol 2018 Jan-Apr;12(1):109-115. Epub 2018 Apr 13.
Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.
Cronkhite-Canada syndrome is characterized by gastrointestinal and ectodermal manifestations. In this paper, we describe a 64-year-old Iranian male, presenting with Cronkhite-Canada syndrome with metastatic colon cancer. The patient was suffering from hair loss, which occurred on the scalp at first and then, during 5 months, extended to the whole body. Read More
BMJ Case Rep 2018 May 8;2018. Epub 2018 May 8.
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.
Cronkhite-Canada syndrome is a rare disease characterised by diffuse gastrointestinal polyposis, diarrhoea, weight loss, skin hyperpigmentation, onychodystrophy and alopecia. More than 500 cases have been described in the medical literature so far. The disease is probably caused by immune-mediated inflammatory mechanisms, and the diagnosis is based on clinical history, physical examination, endoscopic findings and histology. Read More
Med J Armed Forces India 2018 Apr 18;74(2):196-200. Epub 2017 Apr 18.
Assistant Professor (Radiation Oncology), Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
Korean J Gastroenterol 2018 04;71(4):239-243
Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
Clin Gastroenterol Hepatol 2018 Aug 5;16(8):e84-e85. Epub 2018 Apr 5.
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618765893. Epub 2018 Mar 22.
Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Cronkhite-Canada syndrome is a rare syndrome consisting of extensive gastrointestinal polyposis and ectodermal changes including cutaneous hyperpigmentation, alopecia, and onychodystrophy. We report the case of a 45-year-old Caucasian male patient who failed multiple treatments over 2 years including steroids, azathioprine, adalimumab, and cyclosporine. He had recurrent and prolonged hospitalizations because of diarrhea, abdominal pain, weight loss, and malnutrition. Read More
Acta Gastroenterol Belg 2017 Oct-Dec;80(4):530-532
Division of Gastroenterology, McGill University Health Center, 1650 Avenue Cedar, H3G 1A4, Montreal QC, Canada.
We report an unusual case of hamartomatous polyposis with malignant complications in a patient with ulcerative colitis on golimumab and previous thiopurine therapy. This patient was evaluated for iron deficiency anemia and underwent hemicolectomy for extensive right-side predominant inflammatory pseudopolyps. Anemia persisted post-colectomy and subsequent gastroscopy showed a fungating polypoid lesion along with numerous carpet-like strawberry appearing polyps in the stomach extending from the gastro-esophageal junction to the distal part of the antrum, necessitating a gastrectomy. Read More
Gastroenterology Res 2018 Feb 23;11(1):64-67. Epub 2018 Feb 23.
Kaiser Clinic and Hospital, Sao Jose do Rio Preto, SP Brazil.
The Cronkhite-Canada syndrome (CCS) was first reported in 1955, since then more than 500 cases have been reported, indicating an estimated incidence of one case per 1 million inhabitants. The syndrome occurs predominantly in male, with a ratio of three males to two females. Because of the rarity of the syndrome, there are no evidence-based therapies and the treatments described include a combination of therapies, but none is consistently effective. Read More
Acta Chir Belg 2017 Dec 5:1-3. Epub 2017 Dec 5.
a Dienst Abdominale, Kinder- en Reconstructieve Heelkunde , UZA , Antwerpen , Belgium.
Objective: We present the case of a 57-year-old man with a history of Roux-en-Y gastric bypass (RYGB) and colonic polyps who presented with an upper gastrointestinal obstruction based on massive stomach polyposis in the pouch.
Methods: Two months prior to this acute admission, he had undergone resection of the gastric remnant due to massive refractory intraluminal bleeding from a polypoid mass. Ten years earlier, right colectomy was performed due to hypertrophic polyposis unsuitable for endoscopic polypectomy. Read More
Am J Dermatopathol 2017 Nov;39(11):860-862
*Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; and†Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Cronkhite-Canada Syndrome (CCS) presents with gastrointestinal polyposis and the triad of cutaneous abnormalities including nail dystrophy, alopecia, and hyperpigmentation of the skin. The etiology is not well understood. The histology of skin lesion in CCS has not been routinely described. Read More
Medicine (Baltimore) 2017 Sep;96(38):e7466
Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Rationale: Cronkhite-Canada Syndrome (CCS) is an idiopathic, nonhereditary syndrome haracterized by gastrointestinal (GI) polyposis and ectodermal changes including alopecia, onychatrophia, and pigmentation. CCS colon polyps were previously considered to be benign neoplasms. However, serrated adenoma was reported to be associated with malignant neoplasms in some cases of gastric and colorectal carcinomas, and esophageal cancers. Read More
Intern Med 2017 10 15;56(20):2805-2807. Epub 2017 Sep 15.
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Br J Dermatol 2017 08;177(2):348-349
Department of Dermatology-Venereology, National and Kapodestrian University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece.
Gastroenterology Res 2017 Jun 30;10(3):196-198. Epub 2017 Jun 30.
Bassett Medical Center, Cooperstown, NY, USA.
Cronkhite-Canada syndrome (CCS) is a rare non-hereditary disease characterized by chronic diarrhea, diffuse intestinal polyposis and onychodystrophy. We present here a case of a middle-aged female who presented with chronic intermittent bloody diarrhea associated alopecia and loss of finger and toe nails. Labs were remarkable for microcytic anemia and severe hypoalbuminemia. Read More
Ugeskr Laeger 2017 Jul;179(27)
Cronkhite-Canada syndrome (CCS) is a rare non-heritable condition characterized by gastrointestinal polyposis, dysgeusia, malnutrition, total alopecia and onychodystrophia. Two Danish cases of CCS (an 88-year-old female and a 69-year-old male) presented with signs of malnutrition, dyspepsia, vomiting, dysgeusia and hair loss. An upper endoscopy revealed marked oedema and polyposis in the stomach. Read More
World J Gastroenterol 2017 Jun;23(22):4121-4126
Masaki Murata, Shigeki Bamba, Kenichiro Takahashi, Hirotsugu Imaeda, Atsushi Nishida, Osamu Inatomi, Akira Andoh, Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan.
We present a case of Cronkhite-Canada syndrome (CCS) in which the entire intestine was observed using a prototype of magnifying single-balloon enteroscope (SIF Y-0007, Olympus). CCS is a rare, non-familial gastrointestinal polyposis with ectodermal abnormalities. To our knowledge, this is the first report showing magnified intestinal lesions of CCS. Read More
Gastrointest Endosc 2017 11 30;86(5):922-923. Epub 2017 May 30.
Department of Surgical Gastroenterology, Max Super Speciality Hospital, Saket, New Delhi, India.
Nihon Shokakibyo Gakkai Zasshi 2017 ;114(3):431-437
Department of Internal Medicine, National Defense Medical College.
Medicine (Baltimore) 2017 Feb;96(6):e6051
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Rationale: Cronkhite-Canada syndrome (CCS) is a rare disease, the etiology of CCS is currently unknown. Although CCS is widely accepted as a benign disorder, the malignant potential of the polyps in CCS patients is yet controversial.
Patient Concerns: A 55-year-old Chinese male was first admitted to Beijing Friendship Hospital with a 3-month history of frequent watery diarrhea (10-15 times/day), loss of taste, and a weight loss of 10 kg in August 2010. Read More
Br J Dermatol 2017 Aug 24;177(2):531-534. Epub 2017 May 24.
Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, U.K.
Cronkhite-Canada syndrome is an acquired inflammatory polyposis syndrome in which alopecia, onychomadesis and hyperpigmentation occur concurrently with gastrointestinal symptoms. The pathophysiology of alopecia in Cronkhite-Canada syndrome has not been definitively elucidated. We present evidence for alopecia areata incognita as a possible mechanism of hair loss. Read More
Front Neurol 2016 17;7:207. Epub 2016 Nov 17.
Department of Gastroenterology and Hepatology, Singapore General Hospital , Singapore.
The Cronkhite-Canada syndrome (CCS) is a rare disorder of unknown origin characterized by generalized gastrointestinal polyposis, alopecia, hyperpigmentation, and onychodystrophy. We report a case of CCS with concomitant presentation of mononeuritis multiplex. The electrophysiological findings and steroid responsiveness suggests presence of an autoimmune mechanism. Read More
Int J Surg Case Rep 2017 17;30:17-22. Epub 2016 Nov 17.
Dept. Of Surgery, Aditya Birla Memorial Hospital, Pune, India. Electronic address:
Introduction: Cronkhite Canada Syndrome (CCS) is a rare syndrome, described in 1955 by Americans, Leonard Wolsey Cronkhite and Wilma Jeanne Canada in the New England Journal of Medicine . About 450 cases have been reported. Complications, like malignant transformation, unprovoked thromboembolism is known. Read More
Case Rep Crit Care 2016 7;2016:8560871. Epub 2016 Nov 7.
Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
This case report summarizes the first use of intravenous vitamin C employed as an adjunctive interventional agent in the therapy of acute respiratory distress syndrome (ARDS). The two episodes of ARDS occurred in a young female patient with Cronkhite-Canada syndrome, a rare, sporadically occurring, noninherited disorder that is characterized by extensive gastrointestinal polyposis and malabsorption. Prior to the episodes of sepsis, the patient was receiving nutrition via chronic hyperalimentation administered through a long-standing central venous catheter. Read More
BMC Gastroenterol 2016 Oct 6;16(1):123. Epub 2016 Oct 6.
Division of Gastroenterology and Hepatology, Digestive Disease Center, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
Background: Cronkhite-Canada syndrome (CCS) is a rare non-inherited disorder, characterized by gastrointestinal polyposis and ectodermal changes. The pathophysiology remains unclear. Treatment with corticosteroids is considered the mainstay treatment because of its high efficacy. Read More
World J Clin Cases 2016 Aug;4(8):248-52
Ru-Ying Fan, Xiao-Wei Wang, Li-Jun Xue, Jian-Qiu Sheng, Department of Gastroenterology, Beijing Military General Hospital, Beijing 100700, China.
Cronkhite-Canada syndrome (CCS) is a rare but serious protein-losing enteropathy, but little is known about the mechanism. Further more, misdiagnosis is common due to non-familiarity of its clinical manifestation. A 40-year-old male patient was admitted to our hospital because of diarrhea and hypogeusia associated with weight loss for 4 mo. Read More
Adv Exp Med Biol 2016;908:347-69
Department of Pathology, The Johns Hopkins University School of Medicine, 401 N Broadway Weinberg 2242, Baltimore, MD, 21231, USA.
Gastric polyps occur in 1-4 % of patients undergoing gastroscopy. Although most are sporadic, some gastric polyps are part of an underlying hereditary syndrome. Gastric polyps can be seen in each of the well-known gastrointestinal polyposis syndromes, but also in Lynch syndrome and in several rare not primarily gastrointestinal syndromes. Read More
Anticancer Res 2016 Aug;36(8):4215-7
Department of Medicine, Center for Digestive Diseases Karolinska University Hospital, Stockholm, Sweden.
Background/aim: Cronkhite-Canada syndrome (CCS) is a non-inherited, sporadic disorder characterized by generalized gastrointestinal polyps (hamartomas), cutaneous pigmentation, alopecia and onychodystrophy. More than 500 CCS patients have been reported, mostly from Asian countries. Patients with CCS have a propensity to develop colonic traditional serrated adenomas (TSA). Read More
Intern Med 2016 15;55(12):1569-73. Epub 2016 Jun 15.
Department of Internal Medicine & Gastrointestinal Endoscopy, Saga Medical School, Japan.
We herein report a case of Cronkhite-Canada syndrome (CCS) complicated with triple primary cancers. The patient was diagnosed with CCS at 65 years of age. At 76 years of age, one of his colon polyps was diagnosed as adenocarcinoma. Read More
J Med Assoc Thai 2016 Jun;99(6):732-6
Copper deficiency is an uncommon, but treatable cause of hematologic abnormalities. We present and describe two interesting cases in this report. The first case was a 37-year-old man with history of short bowel syndrome and long-term total parenteral nutrition (TPN) presenting with pancytopenia and chronic symmetrical polyarthritis that resembled rheumatoid arthritis. Read More
Am J Gastroenterol 2016 05;111(5):746-8
Department of Medicine, University of California San Diego, La Jolla, California, USA.
Med J Malaysia 2016 02;71(1):37-8
UKM Medical Centre, Faculty of Medicine, Gastroenterology Unit, Kuala Lumpur, Malaysia.
Cronkhite-Canada Syndrome (CCS) is a syndrome characterised by a constellation of signs including but not limited to onychodystrophy of the finger and toe nails, skin hyperpigmentation and alopecia. Endoscopic features showed hamartomatous polyps involving all segments of the gastrointestinal tract with the characteristic exception of being oesophageal sparring. These polyps show confirmation by the presence of eosinophils and mast cells at the lamina propria upon histological studies. Read More
Gastrointest Endosc 2016 Oct 18;84(4):739-40. Epub 2016 Apr 18.
Department of Hepato-Gastroenterology, University Hospital of Rennes, Pontchaillou, France; INSERM U991, University of Rennes 1, Rennes, France.
Case Rep Med 2016 28;2016:4210397. Epub 2016 Jan 28.
Department of Internal Medicine, R.G. Kar Medical College, Kolkata, India.
A young Indian man presented with nine-month history of chronic diarrhea, occasionally mixed with blood and intermittent colicky abdominal pain. He also complained of generalized body swelling for the last three months. On examination, he had diffuse hyperpigmentation of the skin and dystrophic nail changes. Read More
BMC Gastroenterol 2016 Feb 25;16:23. Epub 2016 Feb 25.
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, P. R. China.
Background: Cronkhite-Canada Syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis and ectodermal abnormalities, the estimated incidence is about one per million. Recognizing and curing the disorder face great challenge.
Case Presentation: This report refers to a Chinese 52 year old man with gastrointestinal symptoms and ectodermal abnormalities. Read More
BMJ Case Rep 2016 Jan 27;2016. Epub 2016 Jan 27.
Department of Internal Medicine III-Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
A 64-year-old woman presented with heavy diarrhoea, nausea and weight loss accompanied by alopecia and dystrophic fingernails and toenails. The preceding diagnosis of an inflammatory bowel disease, a common pitfall, was excluded by endoscopic work up. Instead, Cronkhite-Canada syndrome (CCS), a rare polyposis condition, was identified as the reason for this almost pathognomonic combination of diagnostic findings including various polyps throughout the entire intestine and ectodermal abnormalities. Read More
Gastroenterol Hepatol Bed Bench 2016 ;9(1):58-63
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cronkhite- Canada syndrome (CCS) considered as a rare and non-hereditary disorder. Gastrointestinal polyposis and diarrhea along with some extra signs and symptoms such as hypoproteinemia, and epidermal manifestations are recognized in this syndrome. The pathophysiology of this syndrome is not completely understood and it seems that inflammatory processes may be involved. Read More
Int J Surg Pathol 2016 May 31;24(3):185-99. Epub 2015 Dec 31.
The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gastric polyps are found in 1% to 4% of patients undergoing gastroscopy. The vast majority are sporadic, but some gastric polyps indicate an underlying syndrome. Gastric polyps can manifest in each of the gastrointestinal polyposis syndromes, including the recently described gastric adenocarcinoma and proximal polyposis of the stomach syndrome. Read More
Medicine (Baltimore) 2015 Dec;94(52):e2356
From the Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China (YQY, LHW, JXL, QC, JM); and Neurogastroenterology Unit, University Hospital of South Manchester, Manchester, UK (PJW).
Cronkhite-Canada syndrome (CCS) is a rare nongenetic polyposis syndrome first reported by Cronkhite and Canada in 1955. Up to the present time, the literature consists of ∼400 cases of CCS with the majority being reported from Japan although 49 cases have been described in China.CCS is characterized by diffuse polyposis of the digestive tract in association with ectodermal changes, such as onychomadesis, alopecia, and cutaneous hyperpigmentation. Read More
J Crohns Colitis 2015 Dec 11;9(12):1179-80. Epub 2015 Sep 11.
Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan.
J Gastroenterol 2016 Apr 28;51(4):327-36. Epub 2015 Jul 28.
Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Background: First reported in 1955, Cronkhite-Canada syndrome (CCS), a rare syndrome characterized by ectodermal abnormalities and inflammatory changes of the gastrointestinal tract mucosa, has been associated with a poor prognosis and life-threatening malignant complications. In a large population survey, we endeavored to characterize the course and treatment outcome of CCS through clinical and endoscopic assessment, and to explore its optimal treatment and surveillance strategy.
Methods: A retrospective analysis of 210 patients with CCS was conducted via a questionnaire-based nationwide survey of 983 teaching hospitals located throughout Japan. Read More
Australas J Dermatol 2016 May 18;57(2):e69-71. Epub 2015 Jun 18.
Head of Dermatology, Western Health, Melbourne, Victoria, Australia.
We present a case of Cronkhite-Canada syndrome, which is a rare disease classically characterised by hyperpigmentation, alopecia and onychodystrophy associated with clinical gastrointestinal symptoms and hamartomatous gastrointestinal polyps. Management primarily involves immunosuppression and nutritional support, which led to remission in this case. The recognition of cutaneous features may lead to early diagnosis and reduce morbidity and mortality. Read More
Indian J Gastroenterol 2015 May 10;34(3):233-9. Epub 2015 May 10.
Department of Pathology, Amrita Institute of Medical Sciences, Ponekkara, Kochi, 682 041, India.
Background: Several polyposis syndromes of the gastrointestinal tract have been recognized which carry increased risk for cancer and have a genetic predisposition. There is a paucity of literature regarding the occurrence and the burden of colonic polyposis syndromes in the Indian subcontinent. This study attempts to highlight this hitherto unaddressed burden and the associated increased risk for inherited colonic cancer in this geographical location. Read More
J Clin Diagn Res 2015 Mar 1;9(3):OD08-9. Epub 2015 Mar 1.
Post Graduate Trainee, Department of General Medicine, Ipgmer , Kolkata, India .
Cronkhite-Canada syndrome (CCS) is an extremely rare non-inherited condition characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, weight loss and diarrhoea. The aetiology is probably autoimmune and diagnosis is based on history, physical examination, endoscopic findings of gastrointestinal polyposis, and histology. The disease is very rare; approximately 450 cases of CCS have been reported worldwide. Read More