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    10313 results match your criteria Cronkhite-Canada Syndrome

    1 OF 207

    WNT Inhibitory Activity of Malus Pumila miller cv Annurca and Malus domestica cv Limoncella Apple Extracts on Human Colon-Rectal Cells Carrying Familial Adenomatous Polyposis Mutations.
    Nutrients 2017 Nov 18;9(11). Epub 2017 Nov 18.
    Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
    Inhibitors of the Wingless-related Integration site (WNT)/β-catenin pathway have recently been under consideration as potential chemopreventive agents against Familial Adenomatous Polyposis (FAP). This autosomal-dominant syndrome is caused by germline mutations in the gene coding for the protein APC and leads to hyperactivation of the WNT/β-catenin signaling pathway, uncontrolled intestinal cell proliferation and formation of adenocarcinomas. The aim of the present work was to: (i) test, on in vitro cultures of cells carrying FAP mutations and on ex vivo biopsies of FAP patients, the WNT inhibitory activity of extracts from two common southern Italian apples, Malus pumila Miller cv. Read More

    Effects of a Grapevine Shoot Extract Containing Resveratrol and Resveratrol Oligomers on Intestinal Adenoma Development in Mice: In Vitro and In Vivo Studies.
    Mol Nutr Food Res 2017 Nov 10. Epub 2017 Nov 10.
    Institute for Food Toxicology, University of Veterinary Medicine Hannover, Hannover, Germany.
    Scope: Evidence suggests that the dietary consumption of plant extracts containing polyphenols might help prevent the onset of cancers of the gastrointestinal tract. In the present study, the chemopreventive and antiproliferative efficacy of a grapevine shoot extract (Vineatrol(®) 30) containing resveratrol and resveratrol oligomers was investigated in vivo and in vitro.

    Methods And Results: The in vivo study was performed using Apc(Min) mice on a high-fat diet, which represents a model of human adenomatous polyposis, while the potential of the extract as well as some of its isolated constituents to inhibit intestinal adenoma cell proliferation in vitro was investigated using APC10. Read More

    Neoplastic Lesions of Gastric Adenocarcinoma and Proximal Polyposis Syndrome (GAPPS) are Gastric Phenotype.
    Am J Surg Pathol 2017 Nov 3. Epub 2017 Nov 3.
    *PathWest Laboratory Medicine (QE 2 Medical Centre) and University of Western Australia †Department of Gastroenterology, Sir Charles Gairdner Hospital, Perth, WA, Australia.
    Neoplastic lesions of gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) are gastric phenotype. GAPPS was reported in 2011 as a new autosomal dominant gastric polyposis syndrome characterized by involvement of the gastric body/fundus with sparing of the antrum by multiple polyps, reported to be primarily fundic gland polyps (FGPs), with progression to dysplasia and adenocarcinoma of intestinal type. Our series consists of 51 endoscopic biopsies and 5 gastrectomy specimens from 25 patients belonging to a previously defined GAPPS family. Read More

    Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders.
    Surg Pathol Clin 2017 Dec;10(4):931-945
    Department of Pathology, Centro Hospitalar de São João, Porto, Portugal; Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Alameda Professor Hernâni Monteiro, Porto 4200-319, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Rua Júlio Amaral de Carvalho, 45, Porto 4200-135, Portugal; Institute for Research Innovation in Health (i3S), Rua Júlio Amaral de Carvalho, 45, Porto 4200-135, Portugal.
    Hereditary gastric cancer is a relatively rare disease with specific clinical and histopathologic characteristics. Hereditary gastric cancer of the diffuse type is predominantly caused by germline mutations in CDH1. The inherited cause of familial intestinal gastric cancer is unknown. Read More

    Cap polyposis refractory to Helicobacter pylori eradication treated with endoscopic submucosal dissection.
    World J Gastrointest Endosc 2017 Oct;9(10):529-534
    Department of Gastroenterology, Shiga University of Medical Science Hospital, Otsu 520-2192, Japan.
    Cap polyposis is a rare intestinal disorder. Characteristic endoscopic findings are multiple inflammatory polypoid lesions covered by caps of fibrous purulent exudate. Although a specific treatment has not been established, some studies have suggested that eradication therapy for Helicobacter pylori (H. Read More

    Nail Matrix Pathology in Cronkhite-Canada Syndrome: The First Case Report.
    Am J Dermatopathol 2017 Nov;39(11):860-862
    *Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; and†Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Cronkhite-Canada Syndrome (CCS) presents with gastrointestinal polyposis and the triad of cutaneous abnormalities including nail dystrophy, alopecia, and hyperpigmentation of the skin. The etiology is not well understood. The histology of skin lesion in CCS has not been routinely described. Read More

    The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc (Min/+) mice.
    J Biomed Sci 2017 Oct 17;24(1):79. Epub 2017 Oct 17.
    Department of Vaccine Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.
    Background: Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc (Min/+) mice. Microbiota also contains double-stranded RNA (dsRNA), a ligand for TLR3, which activates the toll-like receptor adaptor molecule 1 (TICAM-1, also known as TRIF) pathway.

    Methods: We established Apc (Min/+) Ticam1 (-/-) mice and their survival was compared to survival of Apc (Min/+) Myd88 (-/-) and wild-type (WT) mice. Read More

    Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
    Dis Colon Rectum 2017 Nov;60(11):1137-1146
    1 Department of Digestive Surgery, Hôpital Saint-Antoine, Paris, France 2 Mater Misericordiae University Hospital, Dublin, Ireland 3 Laboratory of Angiogenetics and Oncogenetics, Hôpital Pitié-Salpétrière, Paris, France 4 Centre de Prise en Charge Multidisciplinaire des Personnes Predisposes Héréditairement au Cancer Colorectal, Hôpital Saint-Antoine, Paris, France 5 Department of Digestive Endoscopy, Hôpital Saint-Antoine, Université Pierre et Marie Curie, Paris, France.
    Background: Duodenal polyposis is a manifestation of adenomatous polyposis that predisposes to duodenal or ampullary adenocarcinoma. Duodenal polyposis is monitored by upper GI endoscopies and may require iterative resections and prophylactic radical surgical treatment when malignancy is threatening.

    Objective: The purpose of this study was to evaluate severity scoring for surveillance and treatment in a large series of duodenal polyposis. Read More

    A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.
    Dig Dis Sci 2017 Nov 6;62(11):3014-3020. Epub 2017 Oct 6.
    Department of Medical Genetics, Naval Medical University, 800 Xiangyin Rd., Shanghai, 200433, China.
    Background And Aims: Peutz-Jeghers syndrome (PJS) is an autosomal-dominant genetic disease caused by mutations in the tumor suppressor gene, STK11, which is characterized by gastrointestinal hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing both gastrointestinal and extraintestinal malignancies.

    Methods And Results: We treated a PJS patient without a positive family history, who possessed typical clinical manifestations including polyp canceration. In order to explore the genotype of this patient, blood samples were collected from all the available family members. Read More

    Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids.
    J Cell Sci 2017 Nov 5;130(22):3862-3877. Epub 2017 Oct 5.
    Cell & Developmental Biology, University of Dundee, Dundee DD1 5EH, UK
    Homeostasis of renewing tissues requires balanced proliferation, differentiation and movement. This is particularly important in the intestinal epithelium where lineage tracing suggests that stochastic differentiation choices are intricately coupled to the position of a cell relative to a niche. To determine how position is achieved, we followed proliferating cells in intestinal organoids and discovered that the behaviour of mitotic sisters predicted long-term positioning. Read More

    Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization.
    Cell Rep 2017 Oct;21(1):181-194
    Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, 75015 Paris, France; CNRS URA1961, 75015 Paris, France; INSERM U1221, 75015 Paris, France. Electronic address:
    Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development. Although extensively studied in epithelial transformation, the effect of APC on T lymphocyte activation remains poorly defined. We found that APC ensures T cell receptor-triggered activation through Nuclear Factor of Activated T cells (NFAT), since APC is necessary for NFAT's nuclear localization in a microtubule-dependent fashion and for NFAT-driven transcription leading to cytokine gene expression. Read More

    Magnetic Compression Anastomosis (Magnamosis) for Functional Undiversion of Ileostomy in Pediatric Patients.
    J Laparoendosc Adv Surg Tech A 2017 Oct 4. Epub 2017 Oct 4.
    2 Department of Pediatric Surgery, University of California , San Francisco, San Francisco, California.
    Introduction: Magnamosis forms a compression anastomosis using self-aligning magnetic Harrison rings. The device has been approved by the Food and Drug Administration for first-in-human testing and has been applied in adults for intestinal anastomosis during urologic reconstructions. We now report the first cases of magnamosis to functionally undivert the fecal stream from a previously created loop ileostomy in pediatric patients. Read More

    Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts.
    Cancer Sci 2017 Sep 27. Epub 2017 Sep 27.
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.
    The vasohibin (VASH) family consists of two genes, VASH1 and VASH2. VASH1 is mainly expressed in vascular endothelial cells and suppresses angiogenesis in an autocrine manner, whereas VASH2 is mainly expressed in cancer cells and exhibits pro-angiogenic activity. Employing adenomatous polyposis coli gene mutant mice, we recently reported on the role of Vash2 in the spontaneous formation of intestinal tumors. Read More

    Outcome after restorative proctocolectomy and ileal pouch-anal anastomosis in children and adults.
    Br J Surg 2017 Nov 20;104(12):1640-1647. Epub 2017 Sep 20.
    Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
    Background: Studies comparing the outcome of ileal pouch-anal anastomosis (IPAA) in children and adults are scarce. This complicates decision-making in young patients. The aim of this study was to compare adverse events and pouch function between children and adults who underwent IPAA. Read More

    An increased CD25-positive intestinal regulatory T lymphocyte population is dependent upon Cox-2 activity in the Apc(min/+) model.
    Clin Exp Immunol 2017 Sep 23. Epub 2017 Sep 23.
    MRC Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
    Only mismatch repair (MMR)-deficient colorectal cancer (CRC) appears to respond well to programmed death (PD)-1 inhibition at the present time. Emerging evidence suggests a role for micro-environmental factors such as CD25(+) cells modulating response to PD-1 inhibition. In the Apc(Min/+) model of familial adenomatous polyposis (MMR-proficient CRC), increased Cyclooxygenase-2 (Cox-2) expression by cells which include alternatively activated mononuclear phagocytes promotes intestinal tumorigenesis by mechanisms which may include immune suppression. Read More

    Cronkhite-Canada syndrome associated with colon cancer metastatic to liver: A case report.
    Medicine (Baltimore) 2017 Sep;96(38):e7466
    Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Rationale: Cronkhite-Canada Syndrome (CCS) is an idiopathic, nonhereditary syndrome haracterized by gastrointestinal (GI) polyposis and ectodermal changes including alopecia, onychatrophia, and pigmentation. CCS colon polyps were previously considered to be benign neoplasms. However, serrated adenoma was reported to be associated with malignant neoplasms in some cases of gastric and colorectal carcinomas, and esophageal cancers. Read More

    Adrenal Lesions in Patients With (Attenuated) Familial Adenomatous Polyposis and MUTYH-Associated Polyposis.
    Dis Colon Rectum 2017 Oct;60(10):1057-1064
    1 Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 2 Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 3 Department of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 4 Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 5 Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 6 Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
    Background: The reported proportion of patients with familial adenomatous polyposis who have adrenal lesions varies between 7% and 13% compared with 4% in the general population; the prevalence of adrenal lesions in patients with attenuated familial adenomatous polyposis and MUTYH-associated polyposis is unknown. Data on the clinical relevance and clinical course are limited.

    Objective: We aimed to report on the frequency, characteristics, and progression of adrenal lesions in polyposis patients. Read More

    Dental anomalies in pediatric patients with familial adenomatous polyposis.
    Fam Cancer 2017 Sep 8. Epub 2017 Sep 8.
    Department of Corporate Clinical Research & Department of Research and Graduate Programs, University of Missouri - Kansas City School of Dentistry, 650 E. 25th Street, Kansas City, MO, 64108, USA.
    Familial adenomatous polyposis patients often present with non-malignant extra-intestinal manifestations which include dental anomalies that may be evident prior to the appearance of the colonic adenomas. The aims of this study were to describe the prevalence and type of dental anomalies and the relationships between gene mutations and dental anomalies in these patients. Twenty-two pediatric familial adenomatous polyposis patients and 46 controls, who were age and gender matched participated. Read More

    Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells.
    Oncogene 2017 Aug 28. Epub 2017 Aug 28.
    Cancer Research Center, Xiamen University Medical College, Xiamen, China.
    Berberine, an isoquinoline alkaloid, is a traditional oriental medicine used to treat diarrhea and gastroenteritis. Recently, we reported that it could inhibit the growth of intestinal polyp in animals and in patients with the familial adenomatous polyposis by downregulating β-catenin signaling. However, the intracellular target mediating the effects of berberine remains elusive. Read More

    A review of the impact of obesity on common gastrointestinal malignancies.
    Integr Cancer Sci Ther 2017 18;4(1). Epub 2017 Jan 18.
    Section of Pancreatic Disorders, Division of Gastroenterology, Hepatology and Nutrition, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, USA.
    Obesity is a global pandemic and is a well-recognized risk factor for various gastrointestinal diseases. The prevalence of obesity is increasing across all age groups. There is an emergent need for focused guidelines aimed at reducing the incidence, prevalence, and associated risks of obesity. Read More

    Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management.
    Am J Gastroenterol 2017 Oct 8;112(10):1509-1525. Epub 2017 Aug 8.
    Department of Medicine (Gastroenterology), University of Utah, Salt Lake City, Utah, USA.
    Colorectal cancer (CRC) is the fourth most common cancer amongst men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and several hamartomatous polyposis conditions. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. Read More

    Identification and characterization of functional single nucleotide polymorphisms (SNPs) in Axin 1 gene: a molecular dynamics approach.
    Cell Biochem Biophys 2017 Aug 2. Epub 2017 Aug 2.
    Department of Biosciences, Integral University, Lucknow, India.
    Wnt signaling pathway has been reported to play crucial role in intestinal crypt formation and deregulation of this pathway is responsible for colorectal cancer initiation and progression. Axin 1, a scaffold protein, play pivotal role in the regulation of Wnt/β-catenin signaling pathway and has been found to be mutated in several cancers; primarily in colon cancer. Considering its crucial role, a structural and functional analysis of missense mutations in Axin 1 gene was performed in this study. Read More

    Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
    Nat Chem Biol 2017 Sep 24;13(9):994-1001. Epub 2017 Jul 24.
    Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
    The binding of adenomatous polyposis coli (APC) to its receptor Asef relieves the negative intramolecular regulation of Asef and leads to aberrant cell migration in human colorectal cancer. Because of its crucial role in metastatic dissemination, the interaction between APC and Asef is an attractive target for anti-colorectal-cancer therapy. We rationally designed a series of peptidomimetics that act as potent inhibitors of the APC interface. Read More

    Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth.
    Lab Invest 2017 Nov 31;97(11):1343-1353. Epub 2017 Jul 31.
    Cancer Research Center, Xiamen University Medical College, Xiamen, China.
    The anti-inflammatory and anti-tumor effects of berberine, a traditional Chinese medicine, were separately discovered in pathological intestinal tissues. However, whether the anti-inflammatory effect of berberine contributes to its anti-tumor effect on colitis-associated colorectal cancer (CACRC) remains unknown. In the present study, we found that berberine effectively inhibited colitis-associated tumorigenesis and colonic epithelium hyperproliferation in dextran sulfate sodium (DSS)-treated Apc(Min/+) mice. Read More

    SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling.
    Nat Immunol 2017 Sep 31;18(9):995-1003. Epub 2017 Jul 31.
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.
    Among the features that distinguish type 1 innate lymphoid cells (ILC1s) from natural killer (NK) cells is a gene signature indicative of 'imprinting' by cytokines of the TGF-β family. We studied mice in which ILC1s and NK cells lacked SMAD4, a signal transducer that facilitates the canonical signaling pathway common to all cytokines of the TGF-β family. While SMAD4 deficiency did not affect ILC1 differentiation, NK cells unexpectedly acquired an ILC1-like gene signature and were unable to control tumor metastasis or viral infection. Read More

    Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia.
    Br J Cancer 2017 Sep 25;117(6):1215-1223. Epub 2017 Jul 25.
    Department of Pathology, Leiden University Medical Center, Leiden University, Leiden 2300 RC, The Netherlands.
    Background: A substantial fraction of familial colorectal cancer (CRC) and polyposis heritability remains unexplained. This study aimed to identify predisposing loci in patients with these disorders.

    Methods: Homozygosity mapping was performed using 222 563 SNPs in 302 index patients with various colorectal neoplasms and 3367 controls. Read More

    Cronkhite-Canada Syndrome: A Rare Cause of Chronic Diarrhea.
    Gastroenterology Res 2017 Jun 30;10(3):196-198. Epub 2017 Jun 30.
    Bassett Medical Center, Cooperstown, NY, USA.
    Cronkhite-Canada syndrome (CCS) is a rare non-hereditary disease characterized by chronic diarrhea, diffuse intestinal polyposis and onychodystrophy. We present here a case of a middle-aged female who presented with chronic intermittent bloody diarrhea associated alopecia and loss of finger and toe nails. Labs were remarkable for microcytic anemia and severe hypoalbuminemia. Read More

    Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model.
    PLoS One 2017 14;12(7):e0179888. Epub 2017 Jul 14.
    Institute for Medical BioMathematics, Bene Ataroth, Israel.
    Background: Despite considerable investigational efforts, no method to overcome the pathogenesis caused by loss of function (LoF) mutations in tumor suppressor genes has been successfully translated to the clinic. The most frequent LoF mutation in human cancers is Adenomatous polyposis coli (APC), causing aberrant activation of the Wnt pathway. In nearly all colon cancer tumors, the APC protein is truncated, but still retains partial binding abilities. Read More

    Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.
    PLoS Genet 2017 Jul 14;13(7):e1006870. Epub 2017 Jul 14.
    Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, United States of America.
    Wnt/β-catenin signal transduction directs intestinal stem cell (ISC) proliferation during homeostasis. Hyperactivation of Wnt signaling initiates colorectal cancer, which most frequently results from truncation of the tumor suppressor Adenomatous polyposis coli (APC). The β-catenin-TCF transcription complex activates both the physiological expression of Wnt target genes in the normal intestinal epithelium and their aberrantly increased expression in colorectal tumors. Read More

    Extensive colorectal lymphomatous polyposis complicated by acute intestinal obstruction: a case report.
    J Med Case Rep 2017 Jul 13;11(1):190. Epub 2017 Jul 13.
    Department of Pathology, Hospital do Servidor Público Estadual de São Paulo, Sao Paulo, SP, 04029-000, Brazil.
    Background: Multiple lymphomatous polyposis is a rare type of gastrointestinal lymphoma that extensively infiltrates the intestine. Multiple lymphomatous polyposis originates from the mantle zone of the lymphoma follicle and is considered to be a mantle cell lymphoma, which is a relatively aggressive type of B-cell non-Hodgkin's lymphoma. We report an unusual case of a patient with multiple lymphomatous polyposis with extensive colorectal involvement and acute intestinal obstruction, an atypical complication of this rare disease. Read More

    Familial Associations of Colorectal Cancer with Other Cancers.
    Sci Rep 2017 Jul 12;7(1):5243. Epub 2017 Jul 12.
    Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
    Colorectal cancer (CRC) has a strong familial component which extends to discordant cancers (ie non-CRC tumors). This is best seen in cancer syndromes such as hereditary non-polyposis colorectal cancer (HNPCC) which predisposes to several tumor types. Population-based family studies have also found discordant associations for CRC but they have included cancers which manifest in HNPCC, and there is no convincing evidence of discordant associations beyond the known syndromes. Read More

    [Two cases of the rare Cronkhite-Canada syndrome].
    Ugeskr Laeger 2017 Jul;179(27)
    Cronkhite-Canada syndrome (CCS) is a rare non-heritable condition characterized by gastrointestinal polyposis, dysgeusia, malnutrition, total alopecia and onychodystrophia. Two Danish cases of CCS (an 88-year-old female and a 69-year-old male) presented with signs of malnutrition, dyspepsia, vomiting, dysgeusia and hair loss. An upper endoscopy revealed marked oedema and polyposis in the stomach. Read More

    Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II.
    BMB Rep 2017 Aug;50(8):391-392
    Department of Life Sciences and Research Center for Cell Homeostasis, Ewha Womans University, Seoul 03760, Korea.
    Overexpression of mammalian 2-Cys peroxiredoxin (Prx) enzymes is observed in most cancer tissues. Nevertheless, their specific roles in colorectal cancer (CRC) progression has yet to be fully elucidated. Here, a novel molecular mechanism by which PrxII/Tankyrase (TNKS) interaction mediates survival of adenomatous polyposis coli (APC)-mutant CRC cells was explored. Read More

    Desmoid Tumors in Familial Adenomatous Polyposis.
    Anticancer Res 2017 07;37(7):3357-3366
    Department of Internal Medicine and Clinical Oncology, Aldo Moro University of Bari, Bari, Italy
    Familial adenomatous polyposis (FAP) is a cancer syndrome caused by a germline mutation in the adenomatous polyposis coli (APC) gene. It is characterized by the presence of hundreds of colonic polyps, which have a high tendency to undergo malignant transformation. Among associated lesions in FAP, desmoid tumors represent a common possible life-threatening condition that requires special attention. Read More

    Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
    Nat Commun 2017 06 28;8(1):40. Epub 2017 Jun 28.
    Department of Life Science, Ewha Womans University, Seoul, 120-750, Korea.
    Mammalian 2-Cys peroxiredoxin (Prx) enzymes are overexpressed in most cancer tissues, but their specific signaling role in cancer progression is poorly understood. Here we demonstrate that Prx type II (PrxII) plays a tumor-promoting role in colorectal cancer by interacting with a poly(ADP-ribose) polymerase (PARP) tankyrase. PrxII deletion in mice with inactivating mutation of adenomatous polyposis coli (APC) gene reduces intestinal adenomatous polyposis via Axin/β-catenin axis and thereby promotes survival. Read More

    [Therapeutic effect of a new hybrid technique which combined laparoscopic method and abdominal repair for parastomal hernia repair].
    Zhonghua Wai Ke Za Zhi 2017 Jul;55(7):539-542
    Department of Hernia and Abdominal Wall Surgery, Wuhan Central Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430014, China.
    Objective: To investigate the safety and effectiveness of a new hybrid technique which combined laparoscopic method and abdominal repair (Dual Lap) for parastomal herniarepair. Methods: The clinical and follow-up data of 27 cases who accepted Dual Lap procedure performed at Department of Hernia and Abdominal Wall Surgery, Wuhan Central Hospital, Tongji Medical College of Huazhong University from January 2010 to January 2015 were analyzed retrospectively. The data included 22 male patients and 5 female patients with mean age of 54 years. Read More

    Stat6 Promotes Intestinal Tumorigenesis in a Mouse Model of Adenomatous Polyposis by Expansion of MDSCs and Inhibition of Cytotoxic CD8 Response.
    Neoplasia 2017 Aug 24;19(8):595-605. Epub 2017 Jun 24.
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520. Electronic address:
    Intestinal tumorigenesis in the ApcMin/+ model is initiated by aberrant activation of Wnt pathway. Increased IL-4 expression in human colorectal cancer tissue and growth of colon cancer cell lines implied that IL-4-induced Stat6-mediated tumorigenic signaling likely contributes to intestinal tumor progression in ApcMin/+ mice. Stat6 also appears to promote expansion of myeloid-derived suppressor cells (MDSCs) cells. Read More

    Cancer risk in patients with Peutz-Jeghers syndrome: A retrospective cohort study of 336 cases.
    Tumour Biol 2017 Jun;39(6):1010428317705131
    1 Department of Gastroenterology, Clinical College of Air Force General Hospital, Anhui Medical University, Beijing, China.
    Peutz-Jeghers syndrome is a rare autosomal dominant inherited disorder characterized by mucocutaneous pigmentation and hamartomatous gastrointestinal polyposis. A growing body of evidence has shown that Peutz-Jeghers syndrome could cause an increased risk of various cancers, yet the range of cancer risk estimates was wide among different studies. In this retrospective cohort study, 336 patients with Peutz-Jeghers syndrome in China were enrolled. Read More

    Application of novel magnified single balloon enteroscopy for a patient with Cronkhite-Canada syndrome.
    World J Gastroenterol 2017 Jun;23(22):4121-4126
    Masaki Murata, Shigeki Bamba, Kenichiro Takahashi, Hirotsugu Imaeda, Atsushi Nishida, Osamu Inatomi, Akira Andoh, Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan.
    We present a case of Cronkhite-Canada syndrome (CCS) in which the entire intestine was observed using a prototype of magnifying single-balloon enteroscope (SIF Y-0007, Olympus). CCS is a rare, non-familial gastrointestinal polyposis with ectodermal abnormalities. To our knowledge, this is the first report showing magnified intestinal lesions of CCS. Read More

    Chronic Trichuris muris infection causes neoplastic change in the intestine and exacerbates tumour formation in APC min/+ mice.
    PLoS Negl Trop Dis 2017 Jun 26;11(6):e0005708. Epub 2017 Jun 26.
    School of Biological Sciences, FBMH, MAHSC, University of Manchester, Manchester, United Kingdom.
    Incidences of infection-related cancers are on the rise in developing countries where the prevalence of intestinal nematode worm infections are also high. Trichuris muris (T. muris) is a murine gut-dwelling nematode that is the direct model for human T. Read More

    Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.
    Oncogene 2017 Oct 19;36(42):5885-5896. Epub 2017 Jun 19.
    Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
    Tumor suppressor TP53 is frequently mutated in colorectal cancer (CRC), and most mutations are missense type. Although gain-of-functions by mutant p53 have been demonstrated experimentally, the precise mechanism for malignant progression in in vivo tumors remains unsolved. We generated Apc(Δ716) Trp53(LSL•R270H) villin-CreER compound mice, in which mutant p53(R270H) was expressed in the intestinal epithelia upon tamoxifen treatment, and examined the intestinal tumor phenotypes and tumor-derived organoids. Read More

    Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.
    Nat Med 2017 Jul 19;23(7):878-884. Epub 2017 Jun 19.
    Department of Surgery, Weill Cornell Medical College, New York, New York, USA.
    With the goal of modeling human disease of the large intestine, we sought to develop an effective protocol for deriving colonic organoids (COs) from differentiated human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs). Extensive gene and immunohistochemical profiling confirmed that the derived COs represent colon rather than small intestine, containing stem cells, transit-amplifying cells, and the expected spectrum of differentiated cells, including goblet and endocrine cells. We applied this strategy to iPSCs derived from patients with familial adenomatous polyposis (FAP-iPSCs) harboring germline mutations in the WNT-signaling-pathway-regulator gene encoding APC, and we generated COs that exhibit enhanced WNT activity and increased epithelial cell proliferation, which we used as a platform for drug testing. Read More

    Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus.
    Nat Neurosci 2017 Jul 5;20(7):934-942. Epub 2017 Jun 5.
    Department of Medicine, University of Washington, Seattle, Washington, USA.
    Anorexia is a common manifestation of chronic diseases, including cancer. Here we investigate the contribution to cancer anorexia made by calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) that transmit anorexic signals. We show that CGRP(PBN) neurons are activated in mice implanted with Lewis lung carcinoma cells. Read More

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