WNT Inhibitory Activity of Malus Pumila miller cv Annurca and Malus domestica cv Limoncella Apple Extracts on Human Colon-Rectal Cells Carrying Familial Adenomatous Polyposis Mutations.
- Gennaro Riccio,
- Maria Maisto,
- Sara Bottone,
- Nadia Badolati,
- Giovanni Battista Rossi,
- Gian Carlo Tenore,
- Mariano Stornaiuolo,
- Ettore Novellino
Nutrients 2017 Nov 18;9(11). Epub 2017 Nov 18.
Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
Inhibitors of the Wingless-related Integration site (WNT)/β-catenin pathway have recently been under consideration as potential chemopreventive agents against Familial Adenomatous Polyposis (FAP). This autosomal-dominant syndrome is caused by germline mutations in the gene coding for the protein APC and leads to hyperactivation of the WNT/β-catenin signaling pathway, uncontrolled intestinal cell proliferation and formation of adenocarcinomas. The aim of the present work was to: (i) test, on in vitro cultures of cells carrying FAP mutations and on ex vivo biopsies of FAP patients, the WNT inhibitory activity of extracts from two common southern Italian apples, Malus pumila Miller cv. Read More