39,377 results match your criteria Crohn Disease


Evaluation of fatigue in inflammatory bowel disease - a useful tool in daily practice.

Scand J Gastroenterol 2019 Apr 23:1-6. Epub 2019 Apr 23.

a Department of Gastroenterology , Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E. (IPOLFG) , Lisbon , Portugal.

Background: Fatigue is a common symptom reported in inflammatory bowel disease (IBD) patients. It can be severe and modify the self-perception of disease.

Objective: To evaluate the contribution of clinical and demographic factors to the level of fatigue in IBD patients. Read More

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http://dx.doi.org/10.1080/00365521.2019.1602669DOI Listing

Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis.

J Proteomics 2019 Apr 19. Epub 2019 Apr 19.

Bioprocess Engineering, Otto von Guericke University, Universitätsplatz 2, Magdeburg 39106, Germany. Electronic address:

Crohn's Disease (CD) and Ulcerative Colitis (UC) are chronic inflammatory bowel diseases (IBD) of the gastrointestinal tract. This study used non-invasive LC-MS/MS to find disease specific microbial and human proteins which might be used later for an easier diagnosis. Therefore, 17 healthy controls, 11 CD patients and 14 UC patients but also 13 Irritable Bowel Disease (IBS) patients, 8 Colon Adenoma (CA) patients, and 8 Gastric Carcinoma (GCA) patients were investigated. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.04.009DOI Listing

Should We Divide Crohn's Disease Into Ileum-dominant and Isolated Colonic Diseases?

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

University of California San Diego, La Jolla CA.

Crohn's disease (CD) is an inflammatory bowel disease, which can involve any region of the gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it predominately involves the ileum with or without colonic involvement. Isolated colonic CD was first described in 1960 and since then the phenotypic classification of CD has evolved to stratify patients into isolated ileal, ileocolonic, or isolated colonic involvement. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.040DOI Listing
April 2019
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Detection rates of dysplasia in patients with inflammatory bowel disease using dye-based chromoendoscopy compared with standard- and high-definition white-light colonoscopy: a systematic review and meta-analysis.

Gastrointest Endosc 2019 Apr 19. Epub 2019 Apr 19.

Division of Gastroenterology, Beth Israel Deaconess Medical Center.

Background: Patients with ulcerative colitis have an increased risk of colorectal cancer. We sought to assess the comparative efficacy of standard white-light endoscopy (SDWLE) or high-definition white-light endoscopy (HDWLE) versus dye-based chromoendoscopy through a meta-analysis and rating the quality of evidence using the GRADE system.

Methods: A systematic review of the literature in PubMed, EMBASE, and Web of Sciences was performed through April 2018. Read More

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http://dx.doi.org/10.1016/j.gie.2019.04.219DOI Listing

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: Unusual presentation.

Ann Thorac Med 2019 Apr-Jun;14(2):161-163

Department of Medicine, Division of Pulmonary, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNEC) is an abnormal proliferation of pulmonary neuroendocrine cells that occur without underlying etiology. Here, we report a unique case of 55-year-old female with unusual presentation of DIPNECH and thymoma and on the background history of Crohn's disease that might point toward an autoimmune phenomenon. To the best of our knowledge, there were no previous reports of DIPNECH with either thymoma or Crohn's disease. Read More

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http://dx.doi.org/10.4103/atm.ATM_159_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467018PMC

Adalimumab or Infliximab for the Prevention of Early Postoperative Recurrence of Crohn Disease: Results From the ENEIDA Registry.

Inflamm Bowel Dis 2019 Apr 22. Epub 2019 Apr 22.

Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain.

Background: Anti-tumor necrosis factor agents (anti-TNFs) are efficacious at preventing the postoperative recurrence (POR) of Crohn disease, as demonstrated in 2 randomized controlled trials. However, real-life data for infliximab or adalimumab in this setting are scarce. Our aim was to assess both the efficiency of anti-TNFs at preventing early POR of Crohn disease in clinical practice and the associated risk factors for POR. Read More

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https://academic.oup.com/ibdjournal/advance-article/doi/10.1
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http://dx.doi.org/10.1093/ibd/izz084DOI Listing
April 2019
2 Reads

Medicinal Sulphur Polypore Mushroom Laetiporus sulphureus (Agaricomycetes) Plus Tiny Amounts of Essential Oils Decrease the Activity of Crohn Disease.

Int J Med Mushrooms 2019 ;21(3):267-273

Clinical Research, Medicine Information Formation, Cormontreuil, France.

A mixture of Laetiporus sulphureus (LS) and essential oils of Origanum vulgare, Cinnamomum verum, and Syzygium aromaticum (LOCS) was recommended for 24 patients with Crohn disease (CD). Patients were followed up for at least 24 months (median 32 months; range, 24-54 months). Nineteen patients were compliant with the treatment, although 3 stopped taking it, relapsed, began the LOCS regimen again, and recovered; 5 patients were not compliant at all. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030122DOI Listing
January 2019

The mathematics of Crohn disease.

Authors:
Suzanne Edison

CMAJ 2018 Sep;190(38):E1143

Seattle, Wash.

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http://dx.doi.org/10.1503/cmaj.180764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157494PMC
September 2018

Usefulness of Ustekinumab for Treating a Case of Myelodysplastic Syndrome-Associated Inflammatory Bowel Disease.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Autoimmune diseases including inflammatory bowel disease (IBD) occur in association with myelodysplastic syndrome (MDS). MDS-associated IBD frequently demonstrates a complicated course. We herein report the first case with MDS-associated IBD that was successfully treated with ustekinumab (UST), an anti-interleukin (IL) 12/23p40 monoclonal antibody. Read More

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http://dx.doi.org/10.2169/internalmedicine.2495-18DOI Listing
April 2019
1 Read
0.967 Impact Factor

Teduglutide in Patients With Active Crohn's Disease and Short Bowel Syndrome.

Inflamm Bowel Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1093/ibd/izz087DOI Listing
April 2019
1 Read
4.464 Impact Factor

A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong District of Seoul, Korea in 1986-2015.

J Crohns Colitis 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background And Aims: Although the incidence of inflammatory bowel disease (IBD) is increasing in Asia, data on long-term epidemiologic trends are limited. We performed a 30-year longitudinal study to investigate temporal trends in the epidemiology of Crohn's disease (CD) and ulcerative colitis (UC) in Seoul, Korea.

Methods: This population-based study included 1431 IBD patients (418 CD, 1013 UC) diagnosed between 1986 and 2015 in the Songpa-Kangdong district of Seoul, Korea. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz081DOI Listing
April 2019
1 Read

Immune regulation mechanism of vitamin D level and IL-17/IL-17R pathway in Crohn's disease.

Exp Ther Med 2019 May 13;17(5):3423-3428. Epub 2019 Mar 13.

Department of Gastroenterology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan 471000, P.R. China.

Immune regulation mechanism of vitamin D level and interleukin (IL)-17/IL-17 receptor (IL-17R) pathway in Crohn's disease was studied. Of 40 clean mature healthy rats, 10 rats were used as control group based on random number table, the remaining 30 rats to establish Crohn's disease rat models. After successful modeling, 30 rats were divided into model group, low-dose group and high-dose group with random number table. Read More

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http://dx.doi.org/10.3892/etm.2019.7389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447769PMC

Influence of previous corticosteroid treatment on the efficacy and safety of infliximab therapy in Crohn disease.

Medicine (Baltimore) 2019 Apr;98(15):e15189

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To determine the effect of prior corticosteroid treatment on the results of infliximab (IFX) therapy in patients with Crohn disease (CD).Patients with CD treated with at least 3 IFX infusions between March 2009 and April 2017 were divided into steroid group (n = 43) and nonsteroid group (n = 22) and analyzed retrospectively.The cumulative probabilities of clinical remission and response to IFX at weeks 14, 30, 54, and 78 were higher in the steroid group, though this difference was not statistical significant. Read More

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http://dx.doi.org/10.1097/MD.0000000000015189DOI Listing
April 2019
2 Reads

Serum vitamin D but not zinc levels are associated with different disease activity status in patients with inflammatory bowel disease.

Medicine (Baltimore) 2019 Apr;98(15):e15172

University Medical Center Göttingen, Department of Gastroenterology and Gastrointestinal Oncology, Robert- Koch-Str., Göttingen, Germany.

The incidence of inflammatory bowel disease (IBD) is increasing and the pathogenesis is still not completely understood. Micronutrients like vitamin D [25 (OH)D] and zinc play an important role in enzyme activities and the immune system. As the 25 (OH)D-receptor has been shown to be downregulated in patients with IBD, 25 (OH)D may emerge as a predictive marker for disease improvement. Read More

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http://dx.doi.org/10.1097/MD.0000000000015172DOI Listing
April 2019
2 Reads

Traditional Chinese medicine for management of recurrent and refractory Crohn disease: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15148

Department of Thyroid.

Introduction: Crohn disease (CD) is a chronic relapsing systemic inflammatory disease afflicting the gastrointestinal system with a high morbidity. There has been increasing clinical interest in traditional Chinese medicine (TCM) treatment for CD. This report aims to present patient outcome of therapeutic management using TCM in combination with pharmacologic therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000015148DOI Listing
April 2019
1 Read

Assessing mental health and the relation with variables of demographic and clinical in Crohn's disease patients; 2016-2017.

J Family Med Prim Care 2019 Feb;8(2):728-732

Department of Psychiatry, School of Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.

Background: Crohn's disease is a group of special diseases that are considered in psychiatric studies because there is a contrast between the physical and psychological diseases among the affected patients.

Aim: The aim of this study was assessing mental health and the relation with variables of demographic and clinical in Crohn's disease patients.

Methods: In this epidemiological study, 96 patients with Crohn's disease who referred to educational hospitals in Ahvaz during 2016--2017 were evaluated by demographic and clinical questionnaires and SCL-90 questionnaires for mental health, and the information was analyzed by SPSS software version 22. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_236_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436295PMC
February 2019
2 Reads

Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):838S-851S

Food and Nutrition Service, USDA, Alexandria, VA.

Background: During the Pregnancy and Birth to 24 Months Project, the USDA and US Department of Health and Human Services initiated an evidence review on diet and health in these populations.

Objective: The aim of these systematic reviews was to examine the relationships of never versus ever feeding human milk, shorter versus longer durations of any and exclusive human milk feeding, and feeding a lower versus a higher intensity of human milk to mixed-fed infants with diagnosed celiac disease and inflammatory bowel disease (IBD).

Methods: The Nutrition Evidence Systematic Review team (formerly called the Nutrition Evidence Library) conducted systematic reviews with external experts. Read More

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https://academic.oup.com/ajcn/article/109/Supplement_7/838S/
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http://dx.doi.org/10.1093/ajcn/nqy371DOI Listing
March 2019
2 Reads
6.770 Impact Factor

Mechanisms of microbial pathogenesis and the role of the skin microbiome in psoriasis: A review.

Clin Dermatol 2019 Mar - Apr;37(2):160-166. Epub 2019 Jan 16.

Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA; Departments of Pathology and Social Sciences & Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

The pathogenesis of psoriasis may involve a breakdown of immune tolerance to cutaneous microorganisms. Psoriasis is associated with a higher incidence of Crohn disease and periodontitis, two diseases involving impaired tolerance and abnormal immune activation in response to intestinal and oral microbiota, respectively. In addition, guttate and chronic plaque psoriasis are associated with Streptococcus pyogenes colonization. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.01.011DOI Listing
January 2019
2 Reads

Identification of suitable reference microRNA for qPCR analysis in pediatric inflammatory bowel disease.

Physiol Genomics 2019 Apr 12. Epub 2019 Apr 12.

Lurie Children's Hospital of Chicago, United States.

Pediatric inflammatory bowel disease (IBD) accounts for 10-15% of IBD and is associated with considerable morbidity for patients. Dysregulated microRNAs (miRNA), small non-coding RNA molecules that modulate gene expression, have been the target of research in IBD diagnosis, surveillance and therapy. Proper selection of reference genes, which are a prerequisite for accurate measurement of miRNA expression, are currently lacking. Read More

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http://dx.doi.org/10.1152/physiolgenomics.00126.2018DOI Listing
April 2019
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Diagnostic delay of pediatric inflammatory bowel disease in Saudi Arabia.

Saudi J Gastroenterol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pediatrics, Division of Gastroenterology and Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Background/aim: Delay in the diagnosis of inflammatory bowel disease (IBD) is associated with complications. Our aim was to describe the pattern and risk factors associated with delay in the diagnosis of IBD in Saudi children.

Patients And Methods: This was a multicenter study with a retrospective/prospective design. Read More

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http://dx.doi.org/10.4103/sjg.SJG_457_18DOI Listing
April 2019
1 Read

Diagnosis and Management of Crohn Disease.

JAMA 2019 Apr 10. Epub 2019 Apr 10.

University of Chicago, Chicago, Illinois.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.3684DOI Listing
April 2019
7 Reads

Inflammatory Bowel Disease Serological Immune Markers Anti-Saccharomyces cerevisiae Mannan Antibodies and Outer Membrane Porin C are Potential Biomarkers for Hirschsprung-associated Enterocolitis.

J Pediatr Gastroenterol Nutr 2019 Apr 1. Epub 2019 Apr 1.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.

Objective: Hirschsprung-associated enterocolitis (HAEC) is the most frequent complication in Hirschsprung disease (HSCR) patients. Currently HAEC is diagnosed clinically, leaving uncertainty in the diagnosis thereby potentially leading to over- or undertreatment of patients. The aim of this study was to identify immune biomarkers to aid in the diagnosis of HAEC. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002358DOI Listing
April 2019
2 Reads

Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn's disease: comparison with magnetic resonance enterography.

Intest Res 2019 Apr 10. Epub 2019 Apr 10.

Serviço de Gastroenterologia, Departamento de Clínica Médica, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background/aims: Consistently defining disease activity remains a critical challenge in the follow-up of patients with Crohn's disease (CD). We investigated the potential applicability of abdominal ultrasonography with color Doppler (USCD) analysis for the detection of morphological alterations and inflammatory activity in CD.

Methods: Forty-three patients with CD ileitis/ileocolitis were evaluated using USCD analysis with measurements obtained on the terminal ileum and right colon. Read More

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http://dx.doi.org/10.5217/ir.2018.00124DOI Listing
April 2019
1 Read

Cytomegalovirus reactivation in inflammatory bowel disease: an uncommon occurrence related to corticosteroid dependence.

Mod Pathol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Cytomegalovirus promotes mucosal injury in patients with inflammatory bowel disease, historically affecting 10-25% of ulcerative colitis patients with refractory disease. Viral reactivation is likely related to long-term corticosteroid therapy, which is no longer central to maintenance of patients with inflammatory bowel disease. We hypothesize that viral detection rates have decreased in the modern era, reflecting widespread use of immunomodulatory agents to control inflammation. Read More

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http://dx.doi.org/10.1038/s41379-019-0258-0DOI Listing
April 2019
4 Reads

Emerging views of mitophagy in immunity and autoimmune diseases.

Autophagy 2019 Apr 5:1-15. Epub 2019 Apr 5.

a Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health , Inflammatory Bowel Disease Research Center , Shanghai , China.

Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria. Accumulating evidence implicates elimination of dysfunctional mitochondria as a powerful means employed by autophagy to keep the immune system in check. The process of mitophagy may restrict inflammatory cytokine secretion and directly regulate mitochondrial antigen presentation and immune cell homeostasis. Read More

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http://dx.doi.org/10.1080/15548627.2019.1603547DOI Listing
April 2019
1 Read

Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation.

Gastroenterol Hepatol 2019 Apr 1. Epub 2019 Apr 1.

Servicio de Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, IIS Aragón, Ciberehd, Zaragoza, España.

The association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern) and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02105705193005
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http://dx.doi.org/10.1016/j.gastrohep.2019.02.004DOI Listing
April 2019
3 Reads

The pediatric inflammatory bowel disease INTERMED: A new clinical tool to assess psychosocial needs.

J Psychosom Res 2019 Apr 6;119:26-33. Epub 2019 Feb 6.

CHEO Research Institute, Ottawa, ON, Canada; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada; CHEO Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology & Nutrition, Ottawa, ON, Canada. Electronic address:

Objective: The adult INTERMED is used to determine case complexity and psychosocial needs. We developed and validated a pediatric version of the INTERMED for children and adolescents with inflammatory bowel disease (IBD) and assessed its utility in predicting healthcare utilization.

Methods: We performed a cross-sectional study of children (aged 8-17 y) with IBD (n = 148) and their parents, seen in a hospital-based clinic. Read More

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http://dx.doi.org/10.1016/j.jpsychores.2019.02.002DOI Listing
April 2019
2 Reads

The experience of inflammatory bowel disease patients with healthcare: A survey with the IEXPAC instrument.

Medicine (Baltimore) 2019 Apr;98(14):e15044

Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain.

To assess inflammatory bowel disease (IBD) patients' experience of chronic illness care and the relationship with demographic and healthcare-related characteristics.This cross-sectional survey used the Instrument to Evaluate the EXperience of PAtients with Chronic diseases (IEXPAC) questionnaire to identify parameters associated with a better healthcare experience for IBD patients. IEXPAC questionnaire responses are grouped into 3 factors - productive interactions, new relational model, and patient self-management, scoring from 0 (worst) to 10 (best experience). Read More

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http://dx.doi.org/10.1097/MD.0000000000015044DOI Listing
April 2019
3 Reads

Hepatobiliary and pancreatic manifestations in inflammatory bowel diseases: a referral center study.

BMC Gastroenterol 2019 Apr 3;19(1):48. Epub 2019 Apr 3.

Department of Gastroenterology and Hepatology, Medical school and University of Ioannina, Ioannina, Greece.

Background: Hepatobiliary and pancreatic manifestations have been reported in patients with Crohn's disease or ulcerative colitis. Our aim was to describe the prevalence of hepatobiliary and pancreatic manifestations in inflammatory bowel disease and their association with the disease itself and the medications used.

Methods: Data were retrospectively extracted from the clinical records of patients followed up at our tertiary IBD referral Center. Read More

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http://dx.doi.org/10.1186/s12876-019-0967-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446300PMC
April 2019
2 Reads

Is There a Risk of Lymphoma Associated With Anti-tumor Necrosis Factor Drugs in Patients With Inflammatory Bowel Disease? A Systematic Review of Observational Studies.

Front Pharmacol 2019 19;10:247. Epub 2019 Mar 19.

Unit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Inflammatory bowel diseases (IBDs) are generally not considered a risk factor for the development of lymphoma. When considering IBD treatments, there is good evidence supporting thiopurines (azathioprine, 6-mercaptopurine) as a risk factor for lymphoma. Conversely, the association between the use of anti-TNF agents and the development of lymphoma remains undetermined. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2019.00247
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http://dx.doi.org/10.3389/fphar.2019.00247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433961PMC
March 2019
4 Reads

Presenting symptoms in inflammatory bowel disease: descriptive analysis of a community-based inception cohort.

BMC Gastroenterol 2019 Apr 2;19(1):47. Epub 2019 Apr 2.

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: Few data are currently available on the initial presenting symptoms of patients with inflammatory bowel disease (IBD).

Methods: We evaluated the initial symptom presentation of patients with IBD in the Ocean State Crohn's and Colitis Area Registry (OSCCAR), a community-based inception cohort that enrolled Rhode Island IBD patients at time of diagnosis with longitudinal follow up. A 41-question symptom inventory was administered at time of enrollment to capture symptoms experienced during the 4 weeks preceding diagnosis of IBD. Read More

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http://dx.doi.org/10.1186/s12876-019-0963-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446285PMC
April 2019
4 Reads

Coinfection Attenuates Murine -Induced Crohn's-Like Ileitis by Preserving the Epithelial Barrier and Downregulating the Inflammatory Response.

Front Immunol 2019 18;10:442. Epub 2019 Mar 18.

Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Mice orally infected with develop Crohn's disease (CD)-like enteritis associated with severe mucosal damage and a systemic inflammatory response, resulting in high morbidity and mortality. Previously, helminthic infections have shown therapeutic potential in experimental colitis. However, the role of in -induced CD-like enteritis has not been elucidated. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432985PMC
March 2019
6 Reads

Online training on how to diagnose anoperineal lesions of Crohn's disease: Do pictures matter? A nationwide randomized study.

Clin Res Hepatol Gastroenterol 2019 Mar 29. Epub 2019 Mar 29.

Philippe-Marteau, université Paris Sorbonne, AP-HP, pole digestif, hôpital Saint Antoine 75012 Paris, France. Electronic address:

Any gastroenterologist must be trained to properly diagnose anoperineal lesions in patients with Crohn's disease (APLOC). The aim of this study was to establish whether adding pictures would improve teaching effectiveness of the diagnosis of APLOC to French gastroenterology trainees.

Method: Trainees were asked to answer a first web-based survey consisting of evaluating 12 pictures of APLOC with a closed answer questionnaire. Read More

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http://dx.doi.org/10.1016/j.clinre.2018.12.003DOI Listing
March 2019
4 Reads

Green tea: A possibility in the therapeutic approach of inflammatory bowel diseases?: Green tea and inflammatory bowel diseases.

Complement Ther Med 2019 Apr 19;43:148-153. Epub 2019 Jan 19.

Gastroenterology Department, University Hospital, ABHU, UNIMAR, Marília, São Paulo, Brazil.

Objective: this review aimed to investigate the effects of green tea polyphenols (GTP) in Ulcerative colitis and Crohn´s Disease.

Materials And Methods: The databases used were MEDLINE-and EMBASE (October 2009 to September 2018). Studies that reported the use of green tea and its effects on IBD were included. Read More

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http://dx.doi.org/10.1016/j.ctim.2019.01.015DOI Listing
April 2019
2 Reads

Stepwise Training in Laparoscopic Surgery for Complex Ileocolonic Crohn's Disease: Analysis of 127 Training Episodes.

J Surg Educ 2019 Mar 28. Epub 2019 Mar 28.

Colorectal Unit, Queen Alexandra Hospital - Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom.

Introduction: The inflammation encountered in Crohn's disease makes a minimally invasive approach challenging due to a thickened mesentery, fistulas, abscesses, and large phlegmons with high reported rates of conversion and septic complications. Aim of this study was to evaluate the feasibility of a stepwise approach to training in laparoscopic surgery for complex Crohn's disease.

Methods: Every surgical procedure was divided in 4different training tasks: access and exposure, bowel mobilization, division of the mesentery, anastomosis. Read More

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http://dx.doi.org/10.1016/j.jsurg.2019.03.009DOI Listing
March 2019
3 Reads

Sexual dysfunction and Fertility Problems in Men with Inflammatory Bowel Disease.

World J Mens Health 2019 Mar 22. Epub 2019 Mar 22.

Division of Gastroenterology, Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is usually diagnosed in young individuals. Crohn's disease and ulcerative colitis are the 2 principal forms of IBD. Patients with IBD demonstrate varying degrees of disease activity and sometimes need to undergo bowel surgery such as proctocolectomy with ileal pouch-anal anastomosis that involves removal of the entire colon and rectum with consequent sexual dysfunction. Read More

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http://dx.doi.org/10.5534/wjmh.190007DOI Listing
March 2019
2 Reads

Opportunities and challenges for transcriptome-wide association studies.

Nat Genet 2019 04 29;51(4):592-599. Epub 2019 Mar 29.

Department of Computer Science, Stanford University, Stanford, CA, USA.

Transcriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and gene expression datasets to identify gene-trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes at GWAS loci, by using simulations and case studies of literature-curated candidate causal genes for schizophrenia, low-density-lipoprotein cholesterol and Crohn's disease. We explore risk loci where TWAS accurately prioritizes the likely causal gene as well as loci where TWAS prioritizes multiple genes, some likely to be non-causal, owing to sharing of expression quantitative trait loci (eQTL). Read More

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http://dx.doi.org/10.1038/s41588-019-0385-zDOI Listing
April 2019
4 Reads

Usefulness of Strain Elastography, ARFI Imaging, and Point Shear Wave Elastography for the Assessment of Crohn Disease Strictures.

J Ultrasound Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Objectives: The aim of this study was to evaluate the diagnostic performance of strain elastography, acoustic radiation force impulse (ARFI) imaging and point shear wave elastography (p-SWE) for assessment of the predominant types of intestinal stenosis in Crohn disease.

Methods: Twenty-five patients were enrolled in this study, among whom 25 suspicious stenoses in 25 intestinal segments were studied using gray scale ultrasonography. All 3 elastography methods were performed, and all patients underwent endoscopy within 24 hours with pathologic biopsy. Read More

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http://dx.doi.org/10.1002/jum.14989DOI Listing
March 2019
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Statement of the expert group on the current practice and prospects for the treatment of complex perirectal fistulas in the course of Crohn's disease.

Pol Przegl Chir 2019 Feb;91(1):38-46

II Klinika Chirurgii Ogólnej, Gastroenterologicznej i Nowotworów Układu Pokarmowego, Uniwersytet Medyczny w Lublinie.

Perirectal fistulas in the course of Crohn's disease (CD) constitute an important problem in this group of patients. They are observed in a vast majority of patients with involvement through colorectal inflammation. Perirectal fistulas in CD present a great diagnostic and therapeutic challenge due to the intensified clinical symptoms and worse prognosis than in the case of crypt originating fistulas. Read More

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http://dx.doi.org/10.5604/01.3001.0013.0593DOI Listing
February 2019

Intestinal CD103+CD4+ and CD103+CD8+ T-Cell Subsets in the Gut of Inflammatory Bowel Disease Patients at Diagnosis and During Follow-up.

Inflamm Bowel Dis 2019 Mar 27. Epub 2019 Mar 27.

Crohn & Colitis Centre Rijnstate, Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, the Netherlands.

Background: The integrin CD103 is proposed to be a potential therapeutical target in inflammatory bowel disease (IBD), as it can form a heterodimeric integrin with β7 (Etrolizumab, anti-β7 integrin) on epithelial T cells. Therefore, we aimed to study the frequencies of different intestinal CD103+T-cell subsets, both CD4+ and CD8+, in newly diagnosed, untreated IBD patients at baseline and during follow-up, compared with healthy controls.

Methods: Intestinal biopsies from inflamed segments during colonoscopy and peripheral blood samples were prospectively taken from IBD patients at diagnosis and during follow-up. Read More

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http://dx.doi.org/10.1093/ibd/izz049DOI Listing
March 2019
5 Reads

Food-specific IgG Antibodies in Crohn's Disease: What Came First, the Chicken or the Egg?

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Gastroenterology, Institute of Medicine, Faculty of Medicine, University of Debrecen, Hungary.

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http://dx.doi.org/10.2169/internalmedicine.2379-18DOI Listing
March 2019
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Crohn's Disease Accompanied with Small Intestinal Extramedullary Plasmacytoma.

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Surgery, National Defense Medical College, Japan.

We herein present the case of an immunocompetent 63-year-old man who had previously undergone resection of Crohn's disease (CD)-related small intestinal obstruction more than 30 years ago. He had not been receiving any medication for many years, but had recently started to suffer from ileus. A stenosed site of ileo-cecal anastomosis was identified and therefore was surgically resected, which was diagnosed as CD with small intestinal extramedullary plasmacytoma (EMP). Read More

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http://dx.doi.org/10.2169/internalmedicine.1687-18DOI Listing
March 2019
2 Reads

Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features.

BMC Gastroenterol 2019 Mar 27;19(1):45. Epub 2019 Mar 27.

Department of Medical Sciences, University of Ferrara, St. Anna Hospital, Via Aldo Moro, 8, 44124, Ferrara, Cona, Italy.

Background: Small bowel adenocarcinoma (SBA) is a rare neoplasm, which can occur in a sporadic form or can be associated with a number of predisposing conditions such as hereditary syndromes and immune-mediated intestinal disorders, e.g. celiac disease (CD). Read More

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http://dx.doi.org/10.1186/s12876-019-0964-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437995PMC
March 2019
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The Evolution of Health Care Utilisation and Costs for Inflammatory Bowel Disease Over Ten Years.

J Crohns Colitis 2019 Mar 27. Epub 2019 Mar 27.

Institute of Social and Preventive Medicine [IUMSP], Lausanne University Hospital, Lausanne, Switzerland.

Background And Aims: Inflammatory bowel disease [IBD] places an economic strain on health systems due to expensive pharmaceutical therapy, risk of hospitalisation and surgery, and long-term monitoring. The evolving treatment guidelines advocate rapid scale-up to biologic agents in order to improve health outcomes and quality of life. This study evaluated changes in health care utilisation and expenditures for IBD in Switzerland over time. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz003DOI Listing
March 2019
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European Society of Paediatric Radiology abdominal imaging task force: statement on imaging in very early onset inflammatory bowel disease.

Pediatr Radiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Radiology and Nuclear Medicine, Unit for Paediatric Radiology, Oslo University Hospital, Oslo, Norway.

Very early onset inflammatory bowel disease (VEO-IBD) is defined as disease presenting before the age of 6. These children require a tailored imaging approach because conventional imaging studies can be difficult to perform at such a young age. Unlike inflammatory bowel disease in older children and adults, colonic disease predominates in VEO-IBD, and small-bowel disease is rare. Read More

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http://dx.doi.org/10.1007/s00247-019-04375-8DOI Listing

MR Imaging Evaluation of Inflammatory Bowel Disease in Children:: Where Are We Now in 2019.

Magn Reson Imaging Clin N Am 2019 May 14;27(2):291-300. Epub 2019 Feb 14.

Division of Thoracic Imaging, Department of Radiology, Children's Hospital Boston, Harvard Medical School, 330 Longwood Avenue, Boston, MA 02115, USA; Department of Medicine, Pulmonary Division, Children's Hospital Boston, Harvard Medical School, 330 Longwood Avenue, Boston, MA 02115, USA.

Inflammatory bowel disease (IBD) is an important cause of abdominal pain in the pediatric population. Magnetic resonance enterography (MRE) plays a crucial role in assessment of disease severity, location, extent of disease, and assessment for associated complications. As MR imaging technology has advanced, new techniques have been brought into clinical practice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10649689193000
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http://dx.doi.org/10.1016/j.mric.2019.01.007DOI Listing
May 2019
7 Reads

[Prevalence of ten Immune-mediated inflammatory diseases (IMID) in Spain].

Rev Esp Salud Publica 2019 Mar 25;93. Epub 2019 Mar 25.

Medicina Preventiva y Salud Pública, Universidad Rey Juan Carlos, Madrid, Spain.

Objective: Immune-mediated inflammatory diseases (IMID) are chronic and highly disabling diseases that share inflammatory sequences and immunological dysregulations. Considered as a disease in itself, the prevalence of IMID is virtually unknown. The aim of this study was to assess the prevalence of 10 selected UDI, including rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus, hidradenitis suppurativa, sarcoidosis and uveitis in Spain. Read More

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March 2019
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The role of exclusive enteral nutrition in the preoperative optimization of laparoscopic surgery for patients with Crohn's disease: A cohort study.

Int J Surg 2019 Mar 21;65:39-44. Epub 2019 Mar 21.

Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: Growing evidence has shown that there are significant advantages associated with the use of laparoscopic surgery for Crohn's disease (CD). However, the impact of preoperative exclusive enteral nutrition (EEN) on postoperative complications and CD recurrence following laparoscopic surgery have not been investigated.

Methods: A total of 120 CD patients undergoing bowel resection with laparoscopic surgery were eligible for this study. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.03.012DOI Listing
March 2019
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Risk of inflammatory bowel disease after Campylobacter jejuni and Campylobacter concisus infection: a population-based cohort study.

Scand J Gastroenterol 2019 Mar 24:1-8. Epub 2019 Mar 24.

b Department of Clinical Medicine , Aalborg University , Aalborg , Denmark.

Objectives: In this population-based cohort study, we aimed to examine the risk of IBD following a positive stool culture with Campylobacter jejuni or Campylobacter concisus, as well as following culture-negative stool testing.

Materials And Methods: Patients with a first-time positive stool culture with C. jejuni or C. Read More

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http://dx.doi.org/10.1080/00365521.2019.1578406DOI Listing
March 2019
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Paediatric inflammatory bowel disease: review with a focus on practice in low- to middle-income countries.

Paediatr Int Child Health 2019 02;39(1):48-58

b Bab Alhawa Relief Hospital , Syria.

Inflammatory bowel disease (IBD) should be considered in any child with a persistently altered bowel habit. Growth failure may be a consequence and there may also be extra-intestinal manifestations. Oesophago-gastroduodenoscopy and colonoscopy and conventional histopathology are the diagnostic tools of choice in IBD. Read More

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http://dx.doi.org/10.1080/20469047.2019.1575056DOI Listing
February 2019
2 Reads