41,732 results match your criteria Crohn Disease


MR enterocolonography in patients with Crohn's disease and healthy volunteers - Do we achieve diagnostic bowel distension?

Eur J Radiol 2020 May 30;129:109100. Epub 2020 May 30.

Department of Radiology, Clinical Hospital Center of Rijeka, Rijeka, Croatia; Faculty of Medicine, University of Rijeka, Rijeka, Croatia. Electronic address:

Purpose: The aim of our prospective randomized study was to assess diagnostic quality and stability of bowel distension in patients with Crohn's disease (CD) and healthy volunteers subjected to synchronous magnetic resonance enterography and colonography (MREC), as well as to test the role of water enema and intravenous spasmolytics. The influence of gastric content, age, gender, and body mass on bowel distension was also evaluated.

Method: Study groups included 164 CD patients and 53 healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109100DOI Listing

Safety of Biologic Therapy in Octogenarians and Nonagenarians With Inflammatory Bowel Disease in Ontario: A Case Series.

Inflamm Bowel Dis 2020 Jul 11. Epub 2020 Jul 11.

Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1093/ibd/izaa182DOI Listing

Gastrointestinal diseases and their impact on drug solubility: Crohn's disease.

Eur J Pharm Sci 2020 Jul 7:105459. Epub 2020 Jul 7.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. Electronic address:

In order to investigate differences in drug solubilisation and dissolution in luminal fluids of Crohn's disease (CD) patients and healthy subjects, biorelevant media representative of CD patients were developed using information from literature and a Design of Experiment (DoE) approach. The CD media were characterised in terms of surface tension, osmolality, dynamic viscosity and buffer capacity and compared to healthy biorelevant media. To identify which drug characteristics are likely to present a high risk of altered drug solubility in CD, the solubility of six drugs was assessed in CD media and solubility differences were related to drug properties. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105459DOI Listing

Quantitative Analysis of Intramucosal Mast Cells in Irritable Bowel Syndrome: A Comparison With Inflammatory Bowel Disease in Remission.

J Clin Gastroenterol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Goal: We aimed to study the density of intramucosal mast cells in histologically normal colonic mucosa biopsied from patients with a clinical diagnosis of irritable bowel syndrome (IBS).

Background: Mast cell activation has been thought to implicate in the pathogenesis of inflammatory bowel disease (IBD). Whether it serves a role in the pathogenesis of IBS remains controversial. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001394DOI Listing

Colitis and Crohn's Foundation (India) consensus statements on use of 5-aminosalicylic acid in inflammatory bowel disease.

Intest Res 2020 Jul 13. Epub 2020 Jul 13.

Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India.

Despite several recent advances in therapy in inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) therapy has retained its place especially in ulcerative colitis. This consensus on 5-ASA is obtained through a modified Delphi process, and includes guiding statements and recommendations based on literature evidence (randomized trials, and observational studies), clinical practice, and expert opinion on use of 5-ASA in IBD by Indian gastroenterologists. The aim is to aid practitioners in selecting appropriate treatment strategies and facilitate optimal use of 5-ASA in patients with IBD. Read More

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http://dx.doi.org/10.5217/ir.2019.09176DOI Listing

Colitis and Crohn's Foundation (India): a first nationwide inflammatory bowel disease registry.

Intest Res 2020 Jul 13. Epub 2020 Jul 13.

Purnachandra Gastroenterology Institute, Guntur, India.

Background/aims: The national registry for inflammatory bowel disease (IBD) was designed to study epidemiology and prescribing pattern of treatment of IBD in India.

Methods: A multicenter, cross-sectional, prospective registry was established across four geographical zones of India. Adult patients with ulcerative colitis (UC) or Crohn's disease (CD) were enrolled between January 2014 and December 2015. Read More

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http://dx.doi.org/10.5217/ir.2019.09169DOI Listing

A chance diagnosis of Pelger-Huët anomaly in a 49-year-old woman hospitalized for an acute episode of Crohn disease.

Ann Biol Clin (Paris) 2020 Jul 9. Epub 2020 Jul 9.

Haematology laboratory, Cancer university institute of Toulouse-Oncopole, Toulouse, France.

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http://dx.doi.org/10.1684/abc.2020.1575DOI Listing

Letter to the editor: Comments on "Killer Immunoglobulin-like receptor repertoire analysis in a Caucasian Spanish cohort with inflammatory bowel disease".

Microbiol Immunol 2020 Jul 8. Epub 2020 Jul 8.

Laboratorio de Sistemas Biológicos, Departamento de Ciencias de la Salud, Centro Universitario de los Valle, Universidad de Guadalajara (UDG), Ameca, México.

In 2016, López-Hernández et al. published an interesting article titled Killer Immunoglobulin-like receptor repertoire analysis in a Caucasian Spanish cohort with inflammatory bowel disease (1). In this article, the authors found and reported positive associations between KIR2DL5, KIR2DS1, KIR2DS5 and KIR3DS1 with Inflammatory Bowel Disease (IBD) susceptibility, KIR2DS1 and KIR2DS5 with Crohn's Disease (CD) susceptibility, and KIR2DL5, KIR2DS1 and KIR2DS5 with Ulcerative Colitis (UC) susceptibility. Read More

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http://dx.doi.org/10.1111/1348-0421.12830DOI Listing

"Inflammatory Bowel Disease-Not Just the Bowel's Bane": Peripheral Arterial and Venous Thrombosis in a Patient With Crohn Disease.

Vasc Endovascular Surg 2020 Jul 8:1538574420939360. Epub 2020 Jul 8.

Department of Vascular Surgery, Westchester Medical Center, New York Medical College, Valhalla, NY, USA.

Introduction: Inflammatory bowel disease (IBD) is a chronic multisystem inflammatory condition with associated endothelial dysfunction and dysregulated coagulation. Although deep venous thrombosis (DVT) in IBD has been well described, arterial thrombosis and thromboembolism are less commonly appreciated.

Methods: A 63-year-old male with a known history of Crohn disease presented with acute-onset right arm pain. Read More

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http://dx.doi.org/10.1177/1538574420939360DOI Listing

Population pharmacokinetics of vedolizumab in Asian and non-Asian patients with ulcerative colitis and Crohn's disease.

Intest Res 2020 Jul 10. Epub 2020 Jul 10.

Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.

Background/aims: Vedolizumab is indicated for moderately-to-severely active ulcerative colitis (UC) and Crohn's disease (CD). Because multiple factors may result in different pharmacokinetics and clinical efficacies, understanding determinants of vedolizumab clearance may enhance dose and treatment strategies. The aim was to characterize vedolizumab pharmacokinetics in Asian and non-Asian UC and CD patients. Read More

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http://dx.doi.org/10.5217/ir.2019.09167DOI Listing

Early Indolent Course of Crohn's Disease in Newly Diagnosed Patients is Not Rare and Possibly Predictable.

Clin Gastroenterol Hepatol 2020 Jul 3. Epub 2020 Jul 3.

IBD Center, Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background & Aims: The early stages of Crohn's disease (CD) course are heterogeneous, and it is a challenge to predict the course of disease in patients with new diagnosis.

Methods: We performed an observational longitudinal study of 156 adults (79 male; median age, 27.7 years; 57 treatment naïve) with newly diagnosed CD (within 6 months of enrollment), referred from medical centers and community clinics in Israel from 2013 through 2017. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.069DOI Listing

Adherence to exclusive enteral nutrition by adults with active Crohn's disease is associated with conscientiousness personality trait: a sub-study.

J Hum Nutr Diet 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand.

Background: It is probable that psychosocial factors predict adherence to exclusive enteral nutrition (EEN). Conscientiousness is an intrapersonal factor associated with greater medication adherence and healthy eating behaviours. This sub-study aimed to determine whether adherence to EEN was associated with conscientiousness. Read More

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http://dx.doi.org/10.1111/jhn.12787DOI Listing

A cross-sectional survey on the transitional care of adolescents with inflammatory bowel disease in Hungary.

J Pediatr Nurs 2020 Jul 2. Epub 2020 Jul 2.

Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary; First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary. Electronic address:

Purpose: Since little is known about transitional care practices of adolescents with inflammatory bowel diseases (IBD) in Central-Eastern Europe, we aimed to investigate the currently applied transition practices in Hungary.

Design And Methods: A nationwide, multicentre survey was conducted with the invitation of 41 pediatric and adult IBD centres in February 2019.We developed a 34-item questionnaire, which included single- and multiple-choice questions related to the current clinical practice of IBD transition. Read More

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http://dx.doi.org/10.1016/j.pedn.2020.06.002DOI Listing

Capsule endoscopy in inflammatory bowel disease: when and how.

Intest Res 2020 Jul 7. Epub 2020 Jul 7.

Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.

Capsule endoscopy (CE) is emerging as an important investigation in inflammatory bowel disease (IBD); common types include the standard small bowel CE and colon CE. More recently, the pan-enteric CE was developed to assess the large and small bowel in patients with Crohn's disease (CD). Emerging indications include noninvasive assessment for mucosal healing (both in the small bowel and the colon) and detection of postoperative recurrence in patients with CD. Read More

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http://dx.doi.org/10.5217/ir.2019.09165DOI Listing

Thalidomide use in the management of oromucosal disease: A 10-year review of safety and efficacy in 12 patients.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jun 17. Epub 2020 Jun 17.

Consultant, Oral Medicine, Royal National ENT and Eastman Dental Hospitals, London, UK.

Objective: Thalidomide is an effective systemic agent in the management of ulcerative oromucosal conditions. However, its clinical use is limited because of its known adverse effect profile, including teratogenicity, peripheral neuropathy, and thromboembolic risk. The aim of this study was to review the efficacy and safety of thalidomide over a 10-year period in an Oral Medicine specialty clinic. Read More

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http://dx.doi.org/10.1016/j.oooo.2020.06.009DOI Listing

Magnetic resonance imaging assessment of body composition parameters in Crohn's disease.

Dig Liver Dis 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiology, Rouen University Hospital-Charles Nicolle, 1 rue de Germont, F-76031 Rouen cedex, France; UNIROUEN, Quantif-LITIS EA 4108, Normandie Université, Rouen University Hospital, France. Electronic address:

Background: Body composition, currently evaluated by computed tomography scan, is related to poor evolution and severity of Crohn's disease (CD). Few MRI studies have been performed, yet it is the most commonly used imaging modality for the surveillance of the disease.

Aim: Evaluate the feasibility of MRI body composition measurement and compare the variation according to the activity of the disease. Read More

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http://dx.doi.org/10.1016/j.dld.2020.06.024DOI Listing

Significance of granuloma and granulomatous lymphangitis in the differential diagnosis of Crohn's disease.

J Dig Dis 2020 Jul 3. Epub 2020 Jul 3.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Aim: To clarify the pathological characteristics of granuloma and granulomatous lymphangitis in patients with non-neoplastic bowel diseases and to compare their significance in the differential diagnosis of Crohn's disease.

Methods: Samples were collected from 78 cases of Crohn's disease, 11 cases of intestinal tuberculosis and 33 patients suffering from other non-neoplastic bowel diseases. All patients underwent partial enterectomy and histopathological examination. Read More

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http://dx.doi.org/10.1111/1751-2980.12919DOI Listing

Dual role of sirtuin 1 in inflammatory bowel disease.

Immunopharmacol Immunotoxicol 2020 Jul 3:1-22. Epub 2020 Jul 3.

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India, 147002.

Silent information regulator-1 (SIRT-1), is a member of the class III group of histone deacetylases and is collectively called sirtuins. There have been preclinical and clinical studies indicating the downregulation and decreased activity of sirtuin 1 in various inflammatory bowel disease models. Furthermore, the downregulation of sirtuin 1 is responsible for the sustained production of proinflammatory cytokines and the generation of oxidative stress in colitis. Read More

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http://dx.doi.org/10.1080/08923973.2020.1790595DOI Listing

A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design.

Contemp Clin Trials Commun 2020 Jun 4;18:100573. Epub 2020 May 4.

Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.

Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease >4. Read More

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http://dx.doi.org/10.1016/j.conctc.2020.100573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322804PMC

Medical Management of Crohn's Disease.

Cureus 2020 May 29;12(5):e8351. Epub 2020 May 29.

Medical Education Internal Medicine, Brookwood Baptist Medical Center, Birmingham, USA.

Crohn's disease (CD) is a chronic inflammatory bowel disease that can affect the entire gastrointestinal tract from the mouth to the anus, sparing the rectum. The goal of medical therapy is to induce remission with medications, followed by the administration of maintenance medications to prevent a relapse of the disease. The concept of induction of remission and maintenance of remission is very important, as there is an overlap of medications used to induce and maintain remission. Read More

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http://dx.doi.org/10.7759/cureus.8351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325380PMC

A Rare Case Report and Literature Review of Anabolic-Androgenic Steroids (AAS)-Induced Acute Myocardial Infarction.

Cureus 2020 May 28;12(5):e8332. Epub 2020 May 28.

Library Science, Abington Hospital-Jefferson Health, Abington, USA.

Anabolic-androgenic steroids (AAS) abuse is common in competitive athletes in order to enhance athletic performances. However, AAS abuse is often associated with deleterious side effects including but not limited to cardiovascular diseases, depression, hormonal abnormalities, and cancer. We present a case of a 31-year-old male with a history of Crohn's disease on infliximab and chronic AAS use who had persistent retrosternal chest pain found to have an acute myocardial infarction (MI) without obvious cardiovascular risk factors. Read More

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http://dx.doi.org/10.7759/cureus.8332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325356PMC

Enteroscopy in Crohn's Disease: Are There Any Changes in Role or Outcomes Over Time? A KASID Multicenter Study.

Gut Liver 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background/aims: Although balloon-assisted enteroscopy (BAE) enables endoscopic visualization of small bowel (SB) involvement in Crohn's disease (CD), there is no data on the changes in outcomes over time. We therefore investigated the changes in BAE use on CD patients over different time periods in terms of its role and clinical outcomes.

Methods: We used a multicenter enteroscopy database to identify CD patients with SB involvement who underwent BAE (131 procedures, 116 patients). Read More

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http://dx.doi.org/10.5009/gnl20023DOI Listing

Long term remission after ileorectal anastomosis in Crohn's colitis.

Dig Liver Dis 2020 Jun 29. Epub 2020 Jun 29.

IBD Unit, Department of Medical and Surgical Science, Sant'Orsola-Malpighi Hospital -University of Bologna, via Massarenti 9, 40138 Bologna, Italy. Electronic address:

Background: Crohn's disease represents a heterogeneous entity, but its location tends to be relatively stable overtime. For extensive refractory Crohn's colitis, ileorectal anastomosis after colectomy is an engaging option, since the necessity of a permanent ileostomy is avoided.

Aims: In our study, the long-term outcome of two groups of patients with Crohn's colitis who underwent colectomy and ileorectal anastomosis was compared. Read More

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http://dx.doi.org/10.1016/j.dld.2020.06.021DOI Listing

Efficacy and safety of parenteral vitamin D therapy in infants and children with vitamin D deficiency caused by intestinal malabsorption.

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):112-117. Epub 2020 Jun 30.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Oral supplementation of vitamin D can be inefficient in patients with vitamin D deficiency caused by intestinal malabsorption. This study investigated the efficacy and safety of parenteral vitamin D supplementation in infants and children with vitamin D deficiency caused by intestinal malabsorption.

Methods: This study included 11 patients with vitamin D deficiency who were unresponsive to oral vitamin D or were unable to try oral vitamin D therapy due to underlying conditions. Read More

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http://dx.doi.org/10.6065/apem.1938142.071DOI Listing

Flare-IBD: development and validation of a questionnaire based on patients' messages on an internet forum for early detection of flare in inflammatory bowel disease: study protocol.

BMJ Open 2020 Jul 1;10(7):e037211. Epub 2020 Jul 1.

CHRU-Nancy, INSERM, Université de Lorraine, CIC 1433 Clinical Epidemiology, F-54000 Nancy, France, Nancy, France.

Introduction: Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), are chronic disabling conditions characterised by flares followed by periods of remission. However, patients with IBD are seen every 3-6 months in the outpatient clinic, and the occurrence of a flare between two outpatient visits is not captured. To our knowledge, there is no validated patient-reported outcome (PRO) tool to measure the phenomenon of flare in IBD. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-037211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332197PMC

A case of non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn's disease.

Intest Res 2020 Jul 2. Epub 2020 Jul 2.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

Azathioprine is widely used for the treatment of Crohn's disease (CD). Few cases from Western countries have reported idiopathic non-cirrhotic portal hypertension (NCPH) related to thiopurine therapy in patients with inflammatory bowel disease. Idiopathic NCPH is a rare hepatic condition with intrahepatic portal hypertension but no evidence of cirrhosis or chronic liver disease. Read More

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http://dx.doi.org/10.5217/ir.2020.00016DOI Listing

[Analysis of clinical characteristics and drug treatment of inflammatory bowel disease in children: a single center study].

Zhonghua Er Ke Za Zhi 2020 Jul;58(7):570-575

Department of Gastroenterology, Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.

To analyze the clinical characteristics and efficacy of drug treatment in children with inflammatory bowel disease (IBD) at different ages of onset. The clinical data of 87 children with IBD admitted to Department of Gastroenterology in Children's Hospital, Capital Institute of Pediatrics from January 2009 to December 2018 were collected. The patients were divided into four groups according to the age of onset: 0 -<2 years old group (36 cases), 2 -<6 years old group (10 cases), 6 -<10 years old group (12 cases) and 10 -<18 years old group (29 cases). Read More

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http://dx.doi.org/10.3760/cma.j.cn112140-20200504-00468DOI Listing

Low frequency of COVID-19 in inflammatory bowel diseases.

Dig Liver Dis 2020 Jun 13. Epub 2020 Jun 13.

Department of Systems Medicine, University of Rome "TOR VERGATA", Rome, Italy; IBD group of Tor Vergata University Hospital, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2020.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293454PMC

Commentary on 'Preoperative hypoalbuminemia is an independent risk factor for postoperative complications in Crohn's disease patients with normal BMI: A cohort study'.

Authors:
Meer M Chisthi

Int J Surg 2020 Jun 26;80:49-50. Epub 2020 Jun 26.

Department of General Surgery, Government Medical College, Trivandrum, Kerala, 695011, India. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2020.06.033DOI Listing

Overcoming Workplace Disability in IBD Patients: An Observational Study.

Inflamm Intest Dis 2020 Jun 13;5(2):84-92. Epub 2020 Mar 13.

Department of Surgery, Christchurch Hospital, Christchurch, New Zealand.

Background: Inflammatory Bowel Disease (IBD) can have considerable effects on employment outcomes because of its disabling character.

Goals: We aimed to investigate the impact of IBD in the workplace and to better understand the need for accommodations and adaptations.

Study: Between November 2017 and March 2018, IBD patients were recruited from outpatient clinics in Christchurch Hospital, New Zealand. Read More

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http://dx.doi.org/10.1159/000506702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315202PMC

Management of Primary Nonresponders and Partial Responders to Tumor Necrosis Factor-α Inhibitor Induction Therapy among Patients with Crohn's Disease.

Inflamm Intest Dis 2020 Jun 6;5(2):78-83. Epub 2020 Mar 6.

Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.

Induction therapy with tumor necrosis factor-α (TNF-α) inhibitors is highly effective for the treatment of Crohn's disease. However, there are primary nonresponders (PNR) of TNF-α inhibitors without clinical response during the induction period. In addition, there are partial responders (PR), who show some efficacy, but clinical remission is not achieved by induction therapy. Read More

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http://dx.doi.org/10.1159/000506337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315201PMC

Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report and Systematic Review.

Inflamm Intest Dis 2020 Jun 10;5(2):49-58. Epub 2020 Mar 10.

Clinical Gastroenterology, Universidade de Caxias do Sul, Caxias do Sul, Brazil.

Aim: To report a case of a female patient with hemophagocytic lymphohistiocytosis (HLH) and to systematically review the available cases of the association between HLH and inflammatory bowel disease (IBD).

Methods: In accordance to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, retrieval of studies was based on Medical Subject Headings and Health Sciences Descriptors, which were combined using Boolean operators. Searches were run on the electronic databases Scopus, Web of Science, MEDLINE (PubMed), Biblioteca Regional de Medicina, Latin American and Caribbean Health Sciences Literature, Cochrane Library for Systematic Reviews and Opengrey. Read More

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http://dx.doi.org/10.1159/000506514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315217PMC

Cerebral venous thrombosis: report of 2 cases of hemorrhagic venous infarction.

Radiol Case Rep 2020 Aug 18;15(8):1295-1300. Epub 2020 Jun 18.

Department of Radiology, University Hospital Gabriel Montpied, Clermont Ferrand, France.

Cerebral venous thrombosis (CVT), a rare but potentially severe cerebrovascular disease, is defined as the thrombosis of a cortical or deep cerebral vein, or a cerebral venous sinus. This article reports 2 cases of CVT. In the first case, the patient is a 40-year-old woman with a history of 2 miscarriages, using oral contraception and presenting intense headache, cervical irradiation, and drowsiness. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306535PMC

Significance of G Protein-Coupled Estrogen Receptor in the Pathophysiology of Irritable Bowel Syndrome, Inflammatory Bowel Diseases and Colorectal Cancer.

Front Endocrinol (Lausanne) 2020 12;11:390. Epub 2020 Jun 12.

Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.

The regulatory role of estrogens and nuclear estrogen receptors, i. e., estrogen receptor α and β has been reported in gastrointestinal diseases. Read More

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http://dx.doi.org/10.3389/fendo.2020.00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303275PMC

Outcomes of Initial Subtotal Colectomy for Pediatric Inflammatory Bowel Disease.

J Surg Res 2020 Jun 25;255:319-324. Epub 2020 Jun 25.

Division of Pediatric Surgery, Cohen Children's Medical Center, Northwell Health System, New York, New York; Department of Surgery, Zucker School of Medicine at Hofstra/Northwell Health System, Manhasset, New York. Electronic address:

Background: Subtotal colectomy with end ileostomy (STC-I) has been well established in the adult literature as an initial surgical treatment for refractory inflammatory bowel disease (IBD)-related colitis. However, in the pediatric population, the efficacy of this approach has been less well characterized, likely because of concerns regarding the advisability of leaving a diseased rectum in situ. Our aim was to examine the outcomes after STC-I for refractory IBD at our pediatric tertiary care center. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.026DOI Listing

Varicella zoster virus in inflammatory bowel disease patients: what every gastroenterologist should know.

J Crohns Colitis 2020 Jun 27. Epub 2020 Jun 27.

Department of Gastroenterology & Hepatology, University Hospital Zurich.

Primary Varicella Zoster virus (VZV) infection results in varicella (chickenpox) while its reactivation results in herpes zoster (HZ; shingles). Patients with Inflammatory Bowel Disease (IBD) are susceptible to complications of primary VZV infection and have an increased risk of HZ. Concerns of VZV and HZ infection in the IBD population has been highlighted by the emergence of JAK-inhibitors and their safety profile in this patient population such as tofacitinib for the treatment of ulcerative colitis (UC). Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjaa132DOI Listing

Early Combined Immunosuppression May Be More Effective for Reducing Complications in Isolated Colonic- vs Ileal-Dominant Crohn Disease.

Inflamm Bowel Dis 2020 Jun 27. Epub 2020 Jun 27.

Division of Gastroenterology, University of California San Diego, La Jolla, California.

Background: We assessed whether differential efficacy of early combined immunosuppression (ECI) in comparison with conventional management (CM) is present in patients with Crohn disease (CD) according to disease location.

Methods: In this posthoc analysis of the Randomized Evaluation of an Algorithm for Crohn's Treatment trial, the effect of ECI vs CM modified by disease location (isolated-colonic vs ileal-dominant) in terms of time to first complication (hospitalization, surgery, or disease-related complications-presence of a new abscess, fistula, or stricture; serious worsening of disease activity; extraintestinal manifestations) was analyzed using a marginal Cox proportional hazard model to account for cluster randomization. Factors adjusted included practice size, country, and other covariates selected in a backward logistic regression analysis with the first composition as outcome and P < 0. Read More

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http://dx.doi.org/10.1093/ibd/izaa168DOI Listing

Is this patient's fistula caused by Crohn disease of the pouch?

JAAPA 2020 Jul;33(7):54-56

At the IBD Center at NYU Langone Health in New York City, Joanna Esterow is physician assistant, Eren Esen is a postdoctoral research fellow, and Feza Remzi is a professor of surgery and director of the IBD Center. The authors have disclosed no potential conflicts of interest, financial or otherwise.

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http://dx.doi.org/10.1097/01.JAA.0000668856.35200.4bDOI Listing

Quantitative changes in selected bacteria in the stool during the treatment of Crohn's disease.

Adv Med Sci 2020 Jun 23;65(2):348-353. Epub 2020 Jun 23.

Jagiellonian University Medical College, Faculty of Medicine, Department of Pediatrics, Gastroenterology and Nutrition, Krakow, Poland. Electronic address:

Purpose: The aim of this study was to determine quantitative changes in selected species of bacteria (Bacteroides fragilis, Lactobacillus fermentum, Lactobacillus rhamnosus, Serratia marcescens) in the stool of patients with Crohn's disease (CD) in the course of induction treatment with exclusive enteral nutrition (EEN) or anti-tumor necrosis factor alpha (Infliximab, IFX) vs. healthy controls (HC).

Materials/methods: DNA was isolated from stool samples of CD (n = 122) and HC (n = 17), and quantitative real-time Polymerase Chain Reaction (qPCR) was applied. Read More

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http://dx.doi.org/10.1016/j.advms.2020.06.003DOI Listing

Intestinal dysbiosis in pediatric Crohn's disease patients with mutations.

World J Gastroenterol 2020 Jun;26(22):3098-3109

Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai 201102, China.

Background: Several studies have employed animal models to explore the association between microbiota and interleukin (IL) 10 signaling; however, limited information is available about the human microbiome.

Aim: To characterize the microbiome in patients with mutations and to explore the association between gut dysbiosis and disease severity.

Methods: Fecal samples were collected from patients who were diagnosed with loss-of-function mutations in the gene between January 2017 and July 2018 at the Children's Hospital of Fudan University. Read More

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http://dx.doi.org/10.3748/wjg.v26.i22.3098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304104PMC

Moderate endurance and muscle training is beneficial and safe in patients with quiescent or mildly active Crohn's disease.

United European Gastroenterol J 2020 Jun 25:2050640620936383. Epub 2020 Jun 25.

Department of Medicine I, Agaplesion Markus Hospital, Frankfurt, Germany.

Background And Aims: Physical activity is beneficial in several chronic disorders including Crohn's disease, but the preferred type of exercise is unknown. Our study aimed to examine and compare the safety, feasibility and potential beneficial effects of individual moderate endurance and moderate muscle training in patients with Crohn's disease.

Methods: Quiescent or mildly active (Crohn's disease activity index <220) patients with Crohn's disease were randomly allocated to either a control, endurance, or muscle training group. Read More

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http://dx.doi.org/10.1177/2050640620936383DOI Listing

Comparison of loss of response between anti-tumor necrosis factor alone and combined use with immunomodulators in patients with inflammatory bowel disease.

Korean J Intern Med 2020 Jun 25. Epub 2020 Jun 25.

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Background/aims: Combination therapy with immunomodulators (IMMs) was proposed as a strategy to prevent the development of loss of response (LOR) to anti-tumor necrosis factor (TNF) for patients with inflammatory bowel disease (IBD). However, the effect is unclear in patients already exposed to IMMs. The aim of this study was to evaluate whether combination therapy with IMMs is superior to monotherapy for prevention of LOR to anti-TNF. Read More

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http://dx.doi.org/10.3904/kjim.2019.279DOI Listing

Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease.

J Pathol Transl Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Appendiceal actinomycosis is very rare and its diagnosis is often difficult even in surgically resected specimens. Here we report two cases of appendiceal actinomycosis confirmed by pathologic examination of surgically resected specimens. Characteristic histologic features included transmural chronic inflammation with Crohn-like lymphoid aggregates and polypoid mucosal protrusion into cecal lumen through fibrous expansion of the submucosa. Read More

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http://dx.doi.org/10.4132/jptm.2020.05.17DOI Listing

Faecal calprotectin in dermatology practice.

Clin Exp Dermatol 2020 Jun 24. Epub 2020 Jun 24.

Department of Clinical Chemistry, St Richards Hospital, Chichester, UK.

Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory condition of the bowel with two primary subtypes: Crohn disease and ulcerative colitis. Extraintestinal manifestations are common in IBD and, after musculoskeletal involvement, dermatological lesions are the most common. Currently, colonoscopy and biopsy are the most definitive tests for a diagnosis of IBD. Read More

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http://dx.doi.org/10.1111/ced.14307DOI Listing

Feasibility of intraoperative ultrasound of the small bowel during Crohn's disease surgery.

Tech Coloproctol 2020 Jun 23. Epub 2020 Jun 23.

Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, UK.

Background: Intraoperative assessment of the extent and location of Crohn's disease is not standardised and relies on a mixture of surgeons' experience, tactile feedback and macroscopic appearance. To overcome this variability, we developed a protocol for full intraoperative ultrasound scan of the small bowel and we here report the results of "Assessing the Feasibility and Safety of Using Intraoperative Ultrasound in Ileocolic Crohn's Disease-The IUSS CROHN Study".

Methods: This is a prospective single centre observational study with enrolment of all patients undergoing elective surgery for terminal ileal Crohn's disease from January 2019 to March 2020. Read More

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http://dx.doi.org/10.1007/s10151-020-02268-9DOI Listing

Enteral nutrition for severe malnutrition Crohn's disease patient: Case report.

Medicine (Baltimore) 2020 Jun;99(25):e20112

Clinical Nutrition Department, West China Hospital of Sichuan University.

Introduction: Crohn's disease (CD) is a chronic systemic inflammatory disease with indefinite remission and relapse cycles, which can result in a high incidence rate of malnutrition. There has been increasing clinical interest in enteral nutrition (EN) as an adjunct treatment for CD. This report aims to present a case of a severely malnourished CD patient given EN support in combination with conventional infliximab (IFX) treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000020112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310884PMC

Fibrogenesis in chronic murine colitis is independent of innate lymphoid cells.

Immun Inflamm Dis 2020 Jun 21. Epub 2020 Jun 21.

Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.

Introduction: Insight in the pathogenesis of intestinal fibrosis is an unmet medical need in inflammatory bowel diseases. Studies in murine models and human organ fibrosis point to a potential role of innate lymphoid cells (ILC) in chronic intestinal inflammation and fibrosis.

Materials And Methods: Dextran sodium sulfate (DSS) in drinking water was used to induce chronic colitis and remodeling in C57Bl/6 wild type (WT), RAG-deficient, RAG common γ chain deficient and anti-CD90. Read More

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http://dx.doi.org/10.1002/iid3.321DOI Listing