43,615 results match your criteria Crohn Disease

25 years of biologicals in IBD: What´s all the hype about?

J Intern Med 2021 Jun 15. Epub 2021 Jun 15.

University Hospital Tübingen, Tübingen, Germany.

25 years ago the field was revolutionized by the introduction of infliximab as the first hybrid anti-TNF-antibody. Subsequently, other humanized anti-TNFs were developed and marketed, followed by antibodies to new targets including integrins (vedolizumab) and interleukin (IL) 12/23 (ustekinumab). All these so-called biologicals were shown in registrational trials to induce remission superior to placebo but consistently were effective in only a minority of patients. Read More

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Brain functional changes in patients with Crohn's disease: A resting-state fMRI study.

Brain Behav 2021 Jun 14. Epub 2021 Jun 14.

Department of Radiology, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.

Background: Crohn's disease (CD) is a chronic recurrent intestinal inflammatory disease, often accompanied by poor adaptation and excessive stress response. However, the potential neurological mechanisms of these symptoms have not yet been studied in-depth.

Objective: To investigate alterations in brain activity in patients with Crohn's disease and study the relationship between altered regions and clinical indices. Read More

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What Are the Most Challenging Aspects of Inflammatory Bowel Disease? An International Survey of Gastroenterologists Comparing Developed and Developing Countries.

Inflamm Intest Dis 2021 May 5;6(2):78-86. Epub 2021 Feb 5.

Section of Gastroenterology, Max Rady School of Medicine and University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada.

Background And Aims: As inflammatory bowel disease (IBD) becomes more prevalent, the challenges that gastroenterologists face in managing these patients evolve. We aimed to describe the most important challenges facing gastroenterologists from around the world and compare these between those working in developed and developing countries.

Methods: An online questionnaire was developed, and a link distributed to gastroenterologists. Read More

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Physical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study.

Inflamm Intest Dis 2021 May 24;6(2):61-69. Epub 2021 Feb 24.

Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

Introduction And Objective: Despite the known benefits of physical activity in the management of chronic diseases, the use of exercise as a treatment is relatively underemployed, with many patients reporting their disease to be a barrier. This study aimed to assess physical activity levels, attitudes, and barriers towards exercise in a cohort of patients with inflammatory bowel disease (IBD). In addition, this study aimed to assess possible relationships between physical well-being, psychological well-being, and sociodemographic factors. Read More

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Risk of Urinary Bladder Cancer in Patients With Inflammatory Bowel Diseases: A Meta-Analysis.

Front Surg 2021 26;8:636791. Epub 2021 May 26.

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

A systematic search of the PubMed, Cochrane, Embase, and Web of Science databases was conducted to investigate the risk of urinary bladder cancer (BC) in patients with inflammatory bowel disease (IBD). We identified 168 articles, of which 11 met the inclusion and exclusion criteria. Our analysis included 165,176 patients with IBD, 491 of whom had BC. Read More

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Role of a multidisciplinary team (MDT) in the diagnosis, treatment, and outcomes of inflammatory bowel disease: a single Chinese center's experience.

Biosci Trends 2021 Jun 13. Epub 2021 Jun 13.

Department of Geriatric Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

The incidence of inflammatory bowel disease (IBD) with a poor prognosis is increasing, and a single field is not capable of fully diagnosing and comprehensively treating IBD. The purpose of the current study was to explore the role of a multidisciplinary team (MDT) in the diagnosis and treatment of IBD. Subjects were 55 patients with IBD who underwent surgery at this hospital before the establishment of a MDT (before June 2016) and 276 patients who were discussed by a MDT; 72 of the latter patients underwent surgery. Read More

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Indications and Limitations Associated with the Patency Capsule Prior to Capsule Endoscopy.

Intern Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Japan.

The retention of the capsule used during small bowel capsule endoscopy (SBCE) is a serious complication that can occur in patients with known or suspected small bowel stenosis, and a prior evaluation of the patency of the gastrointestinal (GI) tract is therefore essential. Patency capsule (PC) is a non-diagnostic capsule the same size as the diagnostic SBCE. To date, there are no clear guidelines regarding the contraindications for undergoing a PC evaluation prior to SBCE. Read More

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Demographics and risk factors for pediatric recurrent acute pancreatitis.

Curr Opin Gastroenterol 2021 Jun 11. Epub 2021 Jun 11.

Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA School of Women's and Children's Health, Medicine, University of New South Wales, Australia, Sydney Children's Hospital Randwick, New South Wales, Australia Children's Hospital of Philadelphia, Philadelphia UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Purpose Of Review: Approximately 20-30% of children who experience one episode of acute pancreatitis will have at least one additional episode. For some children, pancreatitis recurs multiple times and in a few years is followed by the diagnosis of chronic pancreatitis. Identifying risk factors for recurrent episodes and disease progression is critical to developing therapeutic interventions. Read More

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Bowel stiffness associated with histopathologic scoring of stenosis in patients with Crohn's disease.

Acta Biomater 2021 Jun 10. Epub 2021 Jun 10.

GIOME, Calmi2, San Diego, California, USA.

Background And Aims: Intestinal stenosis is a common complication of Crohn's Disease (CD). Stenosis is associated with alteration of bowel mechanical properties. This study aims to quantitate the mechanical properties of the intestinal stenosis and to explore associations between histology and mechanical remodeling at stenotic intestinal sites in CD patients. Read More

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A European Survey on Digestive Perianastomotic Ulcerations, a Rare Crohn-Like Disorder Occurring in Children and Young Adults.

J Pediatr Gastroenterol Nutr 2021 Jun 10. Epub 2021 Jun 10.

Department of pediatric surgery, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Paris, France Children's Hospital, Zagreb University Medical School, Zagreb, Croatia Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France Division of Gastroenterology and Hepatology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany Department of Paediatrics, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland Hôpital Timone Enfants, service de pédiatrie multidisciplinaire, Marseille, France Aix Marseille Univ, INSERM, MMG, Marseille, France Department of pediatric gastroenterology and nutrition, Hopital Robert Debré, Assistance Publique Hopitaux de Paris, Paris, France Université de Paris ; INSERM UMR1149 ; Paris, France Unidade de Gastrenterologia Pediátrica, Centro Hospitalar do Porto, Porto, Portugal Bordeaux University Hospital, Paediatric Gastroenterology Unit, CIC 1401, F-33000, Bordeaux, France Department of pediatric gastroenterology and nutrition, Hôpital Trousseau, Assistance Publique-Hopitaux de Paris, Paris, France Children's Hospital, University of Helsinki, Helsinki, Finland Centre Hospitalier Lyon Sud, Pierre Bénite, France Pediatric gastroenterology Unit, Ospedale Maggiore Carlo Alberto Pizzardi di Bologna, Bologna, Italy Sapienza University - Umberto I Hospital, Rome, Italy Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy Department of pediatrics, Hospices Civils de Lyon, Lyon, France. University Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France Department of pediatrics. Centre Hospitalier universitaire de Limoges, Limoges, France Department of pediatrics. Centre Hospitalier Universitaire Clocheville, Tours, France Department of pediatrics. University Normandie, UNICAEN, CHU de Caen Normandie, F-14000 Caen, France INSERM UMR 1073, University Rouen, F-76000 Rouen, France Al Jalila Children's Specialty Hospital, Dubai, United Arab Emirates Shaare Zedek Medical Center, Jerusalem, Jerusalem, Israel.

Objectives: Digestive perianastomotic ulcerations (DPAU) resembling Crohn's disease lesions are long-term complications of intestinal resections, occurring in children and young adults. They are known to be uncommon, severe and difficult to treat.

Methods: In the absence of recommendations, we performed a large European survey among the members of the ESPGHAN working group on inflammatory bowel disease (IBD) in order to collect the experience of expert pediatric gastroenterologists on DPAU. Read More

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Agreement between real-time elastography and delayed enhancement magnetic resonance enterography on quantifying bowel wall fibrosis in Crohn's disease.

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Via F. Sforza 35, Milan 20122, Italy. Electronic address:

Background: the assessment of fibrosis in Crohn's disease (CD) bowel lesions helps to guide therapeutic decisions. Real-time elastography (RTE) and delayed-enhancement magnetic resonance enterography (DE-MRE) have demonstrated good accuracy in quantifying CD-related ileal fibrosis as compared with histological examination. To date no study has compared DE-MRE and RTE. Read More

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Vaccinations in patients with inflammatory bowel disease.

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Department of Biomedical and Clinical Sciences, L Sacco" University of Milan, Via Giovan Battista Grassi 74, Milan 20157, Italy.

Treatment of inflammatory bowel disease (IBD) frequently requires administration of immunosuppressive therapies, which increases susceptibility to a number of infectious pathogens. However, many infections can be prevented by correct and appropriate utilization of vaccinations. While several guidelines have been published on vaccination schedules in patients with IBD, vaccination rates remain suboptimal and even lower than those in the general population. Read More

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Relating the transcriptome and microbiome by paired terminal ileal Crohn disease.

iScience 2021 Jun 5;24(6):102516. Epub 2021 May 5.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, 160# Pu Jian Avenue, Shanghai 200127, China.

Management of terminal ileal Crohn disease (CD) is difficult due to fibrotic prognosis and failure to achieve mucosal healing. A limited number of synchronous analyses have been conducted on the transcriptome and microbiome in unpaired terminal ileum tissues. Therefore, our study focused on the transcriptome and mucosal microbiome in terminal ileal tissues of patients with CD with the aim of determining the role of cross-talk between the microbiome and transcriptome in the pathogenesis of terminal ileal CD. Read More

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Unusual presentation of Crohn's disease.

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

Gastroenterology, Nevill Hall Hospital, Abergavenny, UK.

A previously well 37-year-old woman attended the emergency assessment unit with symptoms of lethargy, breathlessness and peripheral oedema, whereby initial basic investigations revealed an iron deficiency anaemia and serum hypoalbuminaemia. The patient subsequently had multiple admissions to secondary care over a 2-year period due to worsening peripheral and central oedema. Investigations ruled out non-gastrointestinal causes of serum hypoalbuminaemia, such as renal, cardiac and hepatic failures. Read More

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Immunomodulatory Effect of Serum Exosomes From Crohn Disease on Macrophages via Let-7b-5p/TLR4 Signaling.

Inflamm Bowel Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan Province,  China.

Background: Exosomes are extensively reported to be strongly associated with many immunologic diseases, including Crohn disease (CD). Meanwhile, the dysfunction of macrophage activation has been proposed to be critical for the pathogenesis of CD. However, it is an unsettled issue whether serum exosomes from CD could activate macrophages and participate in its pathogenesis. Read More

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Enteritis cystica profunda with lipoma in the second portion of the duodenum.

Yeungnam Univ J Med 2021 Jun 9. Epub 2021 Jun 9.

Division of Gastroenterology, Department of Internal Medicine, Maryknoll Medical Center, Busan, Korea.

Enteritis cystica profunda (ECP), a rare and benign condition, is defined as the displacement of the glandular epithelium into the submucosa and more profound layers of the small intestinal wall leading to the formation of mucin-filled cystic spaces. ECP frequently occurs in the ileum or jejunum and is associated with diseases such as Crohn disease and Peutz-Jeghers syndrome. ECP also develops in the absence of known pathology. Read More

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Endoscopic Ultrasound-Guided Transrectal Drainage of Perirectal Abscess in a Patient with Crohn Disease.

Am J Case Rep 2021 Jun 8;22:e930698. Epub 2021 Jun 8.

Department of Gastroenterology, Deaconess Gateway Hospital, Evansville, IN, USA.

BACKGROUND Crohn disease (CD) is an idiopathic chronic inflammatory disease that can present in the perianal area as perianal CD (pCD), which can present as fistulizing or non-fistulizing. Perirectal abscesses are common complications that are strongly associated with fistula formation. Draining an abscess and not treating the associated fistula leads to a high risk of disease recurrence. Read More

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Psoriatic Alopecia in a Patient With Crohn Disease: An Uncommon Manifestation of Tumor Necrosis Factor α Inhibitors.

Cutis 2021 Apr;107(4):E48-E55

University of Puerto Rico School of Medicine, San Juan. Drs. Carrasquillo, Barrera-Llaurador, Colón-Fontanez, and Martín-García are from the Department of Dermatology, and Dr. Pabón-Cartagena is from the Transitional Year Program.

Tumor necrosis factor α (TNF-α) inhibitors are used to treat multiple inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease, and psoriasis, among others. This family of medications can cause various side effects, some as common as injection-site reactions and others as rare as the paradoxical induction of psoriasiform skin lesions. Alopecic plaques recently have been described as an uncommon adverse effect of the TNF-α inhibitors adalimumab and infliximab. Read More

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Inflammatory bowel disease in Tuzla Canton, Bosnia-Herzegovina: A prospective 10-year follow-up.

World J Gastroenterol 2021 May;27(20):2630-2642

Department of Nephrology, Dialysis and Transplantation, University Clinical Center Tuzla, Tuzla 75000, Tuzlanski Kanton, Bosnia and Herzegovina.

Background: The incidence and prevalence of inflammatory bowel disease (IBD) vary between regions but have risen globally in recent decades. A lack of data from developing nations limits the understanding of IBD epidemiology.

Aim: To perform a follow-up review of IBD epidemiology in the Tuzla Canton of Bosnia-Herzegovina during a 10-year period (2009-2019). Read More

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Evolving role of endoscopy in inflammatory bowel disease: Going beyond diagnosis.

World J Gastroenterol 2021 May;27(20):2521-2530

University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, IL 60637, United States.

Inflammatory bowel disease, encompassing Crohn's disease (CD) and ulcerative colitis, are chronic immune-mediated inflammatory bowel diseases (IBD) that primarily affect the gastrointestinal tract with periods of activity and remission. Large body of evidence exist to strengthen the prognostic role of endoscopic evaluation for both disease activity and severity and it remains the gold standard for the assessment of mucosal healing. Mucosal healing has been associated with improved clinical outcomes with prolonged remission, decreased hospitalization, IBD-related surgeries and colorectal cancer risk. Read More

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Albumin-to-Globulin Ratio at 1 Year after Anti-Tumor Necrosis Factor α Therapy Can Serve as a Prognostic Biomarker in Pediatric Crohn's Disease Patients.

Gut Liver 2021 Jun 9. Epub 2021 Jun 9.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background/aims: The efficacy of biologics for the treatment of Crohn's disease (CD) is affected by the drug concentrations. We aimed to evaluate the importance of albumin and globulin which are known to be associated with drug concentrations as prognostic biomarkers in CD.

Methods: In total, 121 pediatric patients with CD who had received anti-tumor necrosis factor (TNF)-α therapy were retrospectively examined between January 2010 and February 2019. Read More

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Selective Tyrosine Kinase 2 Inhibition for Treatment of Inflammatory Bowel Disease: New Hope on the Rise.

Inflamm Bowel Dis 2021 Jun 5. Epub 2021 Jun 5.

Department of Hepato-Gastroenterology, Nancy University Hospital, Lorraine University, Vandœuvre-lès-Nancy, France.

Conventional systemic and biologic agents are the mainstay of inflammatory bowel disease (IBD) management; however, many of these agents are associated with loss of clinical response, highlighting the need for effective, novel targeted therapies. Janus kinase (JAK) 1-3 and tyrosine kinase 2 (TYK2) mediate signal transduction events downstream of multiple cytokine receptors that regulate targeted gene transcription, including the interleukin-12, interleukin-23, and type I interferon receptors for TYK2. This review summarizes the role of TYK2 signaling in IBD pathogenesis, the differential selectivity of TYK2 inhibitors, and the potential clinical implications of TYK2 inhibition in IBD. Read More

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Chronic intentional chicken bone ingestion mimicking inflammatory bowel disease.

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

Internal Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia, USA.

Ingestion of food by-products, such as peach pits, chicken bones and fish bones, may lead to intestinal complications. The ingestion of the foreign body is often acute and non-intentional. Acute and life-threatening complications include intestinal perforation or obstruction. Read More

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Healing of rectal advancement flaps for anal fistulas in patients with and without Crohn's disease: a retrospective cohort analysis.

BMC Surg 2021 Jun 5;21(1):283. Epub 2021 Jun 5.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Department of General-, Visceral- and Vascular Surgery, Berlin, Germany.

Background: Surgical closure of anal fistulas with rectal advancement flaps is an established standard method, but it has a high degree of healing failure in some cases. The aim of this study was to identify risk factors for anal fistula healing failure after advancement flap placement between patients with cryptoglandular fistulas and patients with Crohn's disease (CD).

Methods: From January 2010 to October 2020, 155 rectal advancement flaps (CD patients = 55, non-CD patients = 100) were performed. Read More

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Ketogenesis alleviates TNFα-induced apoptosis and inflammatory responses in intestinal cells.

Free Radic Biol Med 2021 Jun 1;172:90-100. Epub 2021 Jun 1.

Markey Cancer Center, Lexington, KY, 40536, USA; Department of Surgery, University of Kentucky, Lexington, KY, 40536, USA. Electronic address:

The disturbance of strictly regulated self-regeneration in mammalian intestinal epithelium is associated with various intestinal disorders, particularly inflammatory bowel diseases (IBDs). TNFα, which plays a critical role in the pathogenesis of IBDs, has been reported to inhibit production of ketone bodies such as β-hydroxybutyrate (βHB). However, the role of ketogenesis in the TNFα-mediated pathological process is not entirely known. Read More

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Endocrine disruption in Crohn's disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota products.

FASEB J 2021 Jul;35(7):e21697

Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan de Alicante, Spain.

The relevance of environmental triggers in Crohn's disease remains poorly explored, despite the well-known association between industrialization and disease onset/progression. We have aimed at evaluating the influence of endocrine disrupting chemicals in CD patients. We performed a prospective observational study on consecutive patients diagnosed of CD. Read More

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Oral manifestations in inflammatory bowel disease: A cross-sectional study in Isfahan.

Dent Res J (Isfahan) 2021 23;18. Epub 2021 Feb 23.

Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Various systemic diseases can cause oral manifestations, such as inflammatory bowel disease (IBD). This study is designed to investigate the frequency of oral manifestations in patients with IBD referred to health centers and offices in Isfahan in 2018.

Materials And Methods: This cross-sectional study was done among 161 patients suffering from IBD in Isfahan, Iran. Read More

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February 2021

Sexual Dysfunction in Inflammatory Bowel Disease: What the Specialist Should Know and Ask.

Int J Gen Med 2021 24;14:2003-2015. Epub 2021 May 24.

Department of Internal Medicine, São Paulo State University (Unesp), Medical School, Botucatu, Brazil.

Inflammatory bowel disease (IBD) is a chronic condition that globally affects the health of people who suffer from it, deteriorating their quality of life (QoL). An aspect rarely explored by healthcare providers is the influence of the disease on the sexual functioning of individuals. This discretion is mainly due to an unconscious resistance when asking our patients about their sexual functioning because of a lack of knowledge and skills to tackle this topic or disinterest on the part of professionals, and fear or shame on the part of patients. Read More

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Nodular Pachymeningitis Associated With Relapsing Polychondritis and Crohn Disease Responsive to Adalimumab and Prednisone.

Neurol Neuroimmunol Neuroinflamm 2021 Jul 2;8(5). Epub 2021 Jun 2.

From the Division of Neuroimmunology and Neuroinfectious Diseases (S.K.H., N.V.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Neuroradiology (M.D.M), Department of Radiology, Massachusetts General Hospital, Boston; and Division of Rheumatology, Allergy and Immunology (E.M.M), Department of Medicine, Massachusetts General Hospital, Boston.

Objectives: To review the previous literature on the associations of pachymeningitis with Crohn disease (CD) and relapsing polychondritis (RP) and to describe a new case occurring in association with both in addition to highlighting its positive response to steroid and adalimumab treatment.

Methods: We review the patient's clinical presentation, diagnostic workup (serum and CSF testing), and MRI findings in detail and chronicle the response of the pachymeningitis to intensive immunotherapy. We contrast this case against previous reports of pachymeningitis occurring in association with RP and inflammatory bowel disease that were found on PubMed. Read More

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