39,081 results match your criteria Crohn Disease


[Herbal cake-partitioned moxibustion improves intestinal epithelial barrier dysfunction by suppressing TNF-α-mediated apoptosis pathway of intestinal epithelium in rats with Crohn's disease].

Zhen Ci Yan Jiu 2019 Jan;44(1):1-7

Yueyang Clinical Medical School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai Research Institute of Acupuncture-moxibustion and Meridian, Shanghai 200030.

Objective: To observe the effect of herbal cake-partitioned moxibustion (Moxi) on tumor necrosis factor (TNF)-α/ TNF receptor 1 (TNFR1)-associated death domain (TRADD) / Fas-associated death domain (FADD) pathway-mediated apoptosis of intestinal epithelial cells in Crohn's disease (CD) rats, so as to explore its underlying mechanisms in the treatment of CD.

Methods: Forty-eight SD male rats were randomly divided into normal, model, Moxi and medication groups (=12 rats in each). The CD model was established by intra-annual perfusion of 2,4,6-trinitrobenzene sulfonic acid (TNBS) solution (TNBS∶50% alcohol=2∶1, 3 mL/kg), once every 7 days, 4 times altogether. Read More

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http://dx.doi.org/10.13702/j.1000-0607.180512DOI Listing
January 2019

Anti-TNF biologic therapy does not increase postoperative morbidity in pediatric Crohn's patients.

J Pediatr Surg 2019 Jan 18. Epub 2019 Jan 18.

Division of Pediatric Surgery, Mayo Clinic, Rochester, MN, USA.

Introduction: Limited knowledge exists as to what impact preoperative biologic therapy has on postoperative complications in pediatric patients undergoing abdominal surgery for Crohn's disease (CD). Therefore, we sought to determine the 30-day postoperative infectious complication rate among pediatric CD patients who received biologic therapy within 12 weeks of an abdominal operation.

Methods: A retrospective chart review was performed on pediatric (<18 years of age) CD patients who underwent an abdominal operation between 1/1/2008 and 12/31/2017. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.006DOI Listing
January 2019

Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease.

Gastroenterology 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, Pelvic Floor Unit, Aarhus University Hospital, Aarhus, Denmark.

Background And Aims: Perianal fistulas are common in patients with Crohn´s disease (CD). Injections of cultured autologous and allogeneic adipose tissue-derived stem cells have been shown to heal CD-associated fistulas. Unfortunately, this treatment is time-consuming and expensive. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.005DOI Listing
February 2019

Acute abdominal pain in patients with Crohn's disease: what urgent imaging tests should be done?

Radiologia 2019 Feb 13. Epub 2019 Feb 13.

Servicio de Radiología, Hospital Universitario Ramón y Cajal, Madrid, España.

Crohn's disease is an autoimmune disease that predominantly affects the gastrointestinal tract. Crohn's disease is diagnosed at a young age and runs a chronic course with acute flare-ups. When patients with Crohn's disease present with flare-ups at the emergency department, they are usually managed in a way similar to patients with acute abdomen; there is no consensus about the most appropriate imaging work-up for patients with flare-ups of Crohn's disease. Read More

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http://dx.doi.org/10.1016/j.rx.2018.12.003DOI Listing
February 2019

A Validated Score Assessing the Risk for an Intra-Abdominal Abscess in Patients with Crohn's Disease Presenting at the Emergency Department.

J Crohns Colitis 2019 Feb 14. Epub 2019 Feb 14.

Institute of Gastroenterology and Liver Diseases, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.

Background And Aims: A majority of acutely-ill Crohn's disease (CD) patients who present to Emergency Department (ED) will undergo an abdominal CT to rule out disease complications. We aimed to generate a simple non-invasive scoring model to predict the presence of an intra-abdominal abscess in CD patients in the ED.

Methods: We performed a retrospective case control study at four Israeli hospitals from January-1 st-2010 to May-30 th-2018. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz043DOI Listing
February 2019

Long-term efficacy and safety of biosimilar infliximab (CT-P13) after switching from originator infliximab: Open-label extension of the NOR-SWITCH trial.

J Intern Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Rheumatology, Diakonhjemmet Hospital, Oslo.

Background And Objectives: The 52-week, randomized, double blind, non-inferiority, government funded NOR-SWITCH trial demonstrated that switching from infliximab originator to less expensive biosimilar CT-P13 was not inferior to continued treatment with infliximab originator. The NOR-SWITCH extension trial aimed to assess efficacy, safety and immunogenicity in patients on CT-P13 throughout the 78-week study period (maintenance group) vs patients switched to CT-P13 at week 52 (switch group).

Primary Outcome: disease worsening during follow-up based on disease specific composite measures. Read More

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http://dx.doi.org/10.1111/joim.12880DOI Listing
February 2019

Risk Factors and Clinical Outcomes of Head and Neck Cancer in Inflammatory Bowel Disease: A Nationwide Cohort Study.

Inflamm Bowel Dis 2018 Aug;24(9):2015-2026

Inflammatory Bowel Disease Centre, Department of Gastroenterology and Hepatology.

Background: Immunosuppressed inflammatory bowel disease (IBD) patients are at increased risk to develop extra-intestinal malignancies. Immunosuppressed transplant patients show increased incidence of head and neck cancer with impaired survival. This study aims to identify risk factors for oral cavity (OCC) and pharyngeal carcinoma (PC) development in IBD, to compare clinical characteristics in IBD with the general population, and to assess the influence of immunosuppressive medication on survival. Read More

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https://academic.oup.com/ibdjournal/article/24/9/2015/499994
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http://dx.doi.org/10.1093/ibd/izy096DOI Listing
August 2018
1 Read

ANALYSIS OF THE CLINICAL CHARACTERISTICS OF PERIANAL FISTULISING CROHN'S DISEASE IN A SINGLE CENTER.

Arq Bras Cir Dig 2019 Feb 7;32(1):e1420. Epub 2019 Feb 7.

The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Background: Clinical characteristics are keys to improve identification and treatment of Crohn´s disease (CD) so that large sample analysis is of great value.

Aim: To explore the clinical characteristics of perianal fistulising CD.

Methods: Analysis of 139 cases focused on their clinical data. Read More

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http://dx.doi.org/10.1590/0102-672020180001e1420DOI Listing
February 2019

Characterization of inflammatory bowel disease management by vedolizumab and concomitant treatments in real-life clinical practice.

Biologicals 2019 Feb 9. Epub 2019 Feb 9.

Department of Gastroenterology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Limited data is available on vedolizumab combination therapies in real-world clinical practice. Here, we evaluated the concomitant corticosteroid, immunosuppressive, and 5-aminosalicylic acid utilization of inflammatory bowel disease (IBD) patients treated with vedolizumab in a nationwide, retrospective, non-interventional, multi-centre chart review study. All adult patients from 27 Finnish gastroenterology centres with a diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) who had at least one vedolizumab infusion since it's availability in Finland were included in the study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10451056183033
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http://dx.doi.org/10.1016/j.biologicals.2019.01.007DOI Listing
February 2019
1 Read

Over 1-Year Followup of Laparoscopic Treatment of Enterovesical Fistula.

JSLS 2019 Jan-Mar;23(1)

Department of General Surgery and Oncological Surgery-Surgery C, Sheba Medical Center, Tel Hashomer, Israel.

Background And Objective: Entero vesical fistulas (EVFs) are an uncommon complication mainly of diverticular disease (70%) and less commonly of Crohn's disease (10%). Only about 10% are caused by malignancies. At this time, it is unclear whether the laparoscopic approach can be routinely proposed as a safe procedure for patients with EVF. Read More

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http://dx.doi.org/10.4293/JSLS.2018.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364704PMC
February 2019

Raynaud's phenomenon and inflammatory bowel disease: The possible role of microcirculation.

Eur J Intern Med 2019 Feb 5. Epub 2019 Feb 5.

Unidade de Doenças Auto-Imunes, Internal Medicine Department 7.2, Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.ejim.2019.02.001DOI Listing
February 2019
6 Reads

MRI reveals different Crohn's disease phenotypes in children and adults.

Eur Radiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics and Pediatric Neuropsychiatry, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale del Policlinico, 155, 00161, Rome, Italy.

Objectives: To identify differences between two cohorts of adult and pediatric patients affected by Crohn's disease (CD), with regard to lesion location in the small intestine and colon-rectum, lesion activity, and prevalence of perianal disease (PD), using MRI as the main diagnostic tool.

Methods: We retrospectively reviewed 350 consecutive MRI examinations performed between 2013 and 2016 in outpatients or inpatients with histologically proven CD, monitored by the Gastroenterology and Pediatric Units of our Hospital. The magnetic resonance enterography (MRE) protocol for adult and pediatric CD patients routinely includes evaluation of nine different intestinal segments (from jejunum to rectum) and of the anal canal. Read More

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http://dx.doi.org/10.1007/s00330-019-6006-5DOI Listing
February 2019
1 Read

Long-term outcomes of patients with Crohn's disease who received infliximab or adalimumab as the first-line biologics.

J Gastroenterol Hepatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background And Aim: Although previous studies compared the efficacy of infliximab (IFX) versus adalimumab (ADA) as the first-line biologics for Crohn's disease (CD), the difference in long-term prognosis based on which biologic was used first has scarcely been reported. In particular, the clinical courses after loss of response (LOR) of the first-line biologics are largely unknown.

Methods: A multicenter, retrospective study was performed. Read More

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http://dx.doi.org/10.1111/jgh.14624DOI Listing
February 2019

Long-term Results of the Side-to-side Isoperistaltic Strictureplasty in Crohn Disease: 25-year Follow-up and Outcomes.

Ann Surg 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgery, University of Chicago, Chicago, IL.

MINI: The side-to-side isoperistaltic strictureplasty (SSIS) is a safe and effective procedure in patients with extensive fibrostenosing Crohn disease of the small bowel. Eighty-six percent of patients maintain the original SSIS after a median follow-up of 11 years.

Objective: Review the long-term outcomes of the side-to-side isoperistaltic strictureplasty (SSIS) and its effects on bowel preservation in Crohn disease (CD). Read More

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http://dx.doi.org/10.1097/SLA.0000000000003221DOI Listing
January 2019
2 Reads

Carbohydrate Monotony as Protection and Treatment for Inflammatory Bowel Disease.

J Crohns Colitis 2019 Jan 30. Epub 2019 Jan 30.

Section of Pediatric Gastroenterology, Texas Children's Hospital Baylor College of Medicine.

The nutritional developmental origins of inflammatory bowel disease(s) (IBDs: Crohn's disease or Crohn disease [CD] and ulcerative colitis [UC]) and their diet-based treatments continue to receive increasing attention. There is growing evidence for the success of nutrition-based treatments, such as exclusive enteral nutrition (EEN) and the specific carbohydrate diet (SCD) in both pediatric and adult patients. Beyond these two dietary interventions, symptomatic benefit in IBD has also been shown from a gluten-free diet (GFD) and paleolithic diet (PALEO), among others. Read More

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https://academic.oup.com/ecco-jcc/advance-article/doi/10.109
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http://dx.doi.org/10.1093/ecco-jcc/jjz011DOI Listing
January 2019
7 Reads

Adrenomedullin: A Novel Therapy for Intractable Crohn's Disease with a Loss of Response to Infliximab.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan.

A 35-year-old man with refractory Crohn's disease showed a loss of response to infliximab after requiring treatment with infliximab at 10 mg/kg together with steroid to maintain remission. His symptoms recurred, and colonoscopy showed extensive active ulcers in the colon. Adrenomedullin therapy was started in addition to the conventional infliximab therapy. Read More

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http://dx.doi.org/10.2169/internalmedicine.1791-18DOI Listing
February 2019
2 Reads

Inflammation and Aortic Pulse Wave Velocity: A Multicenter Longitudinal Study in Patients With Inflammatory Bowel Disease.

J Am Heart Assoc 2019 Feb;8(3):e010942

8 Department of Pharmacology HEGP Université Paris Descartes AP-HP INSERM U970 Paris France.

Background Inflammatory bowel disease ( IBD ) is characterized by a low prevalence of traditional risk factors, an increased aortic pulse-wave velocity ( aPWV ), and an excess of cardiovascular events. We have previously hypothesized that the cardiovascular risk excess reported in these patients could be explained by chronic inflammation. Here, we tested the hypothesis that chronic inflammation is responsible for the increased aPWV previously reported in IBD patients and that anti-TNFa (anti-tumor necrosis factor-alpha) therapy reduce aPWV in these patients. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.010942
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http://dx.doi.org/10.1161/JAHA.118.010942DOI Listing
February 2019
4 Reads

Association of Crohn's disease with Foxp3 gene polymorphisms and its colonic expression in Chinese patients.

J Clin Lab Anal 2019 Feb 1:e22835. Epub 2019 Feb 1.

Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Background: Fork head/winged helix transcription factor (Foxp3) plays a pivotal role in regulatory T (Treg) cells. The present study aimed to assess the association of Crohn's disease (CD) with Foxp3 polymorphisms and its colonic expression in Chinese patients.

Methods: The Foxp3 polymorphisms, rs3761547, rs2232365, rs2294021, and rs3761548, were examined by SNaPshot in 268 CD patients and 490 controls. Read More

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http://dx.doi.org/10.1002/jcla.22835DOI Listing
February 2019
1 Read

Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn's disease? - a systematic review.

Intest Res 2019 Feb 7. Epub 2019 Feb 7.

Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.

Fecal calprotectin (FC) is a highly sensitive disease activity biomarker in inflammatory bowel disease. However, there are conflicting reports on whether the diagnostic accuracy in Crohn's disease is influenced by disease location. The aim of this study was to undertake a systematic review of the published literature. Read More

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http://dx.doi.org/10.5217/ir.2018.00114DOI Listing
February 2019
1 Read

Stem Cell Therapy for Perianal Crohn's Disease.

Ter Arkh 2018 Apr;90(3):60-66

Moscow Clinical Research Center, Moscow, Russia.

Aim: To compare the effectiveness of the effect of combination therapy (local and systemic administration) with bone marrow mesenchymal stromal cells (MSC), anticlitokine therapy with infliximab (IFX), and antibiotic (AB)/immunosuppressive (IS) therapy on the frequency of healing of simple perianal fistulas in Crohn's disease.

Materials And Methods: In our study, the 1-st group of patients aged 19 to 58 years (Me-29) (n = 12) received MSCs culture systemically according to the scheme and locally. The 2-nd group of patients with CD (n = 10) from 20 to 68 years old (Me-36) received anticytokine therapy with infliximab (IFX) according to the scheme. Read More

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http://dx.doi.org/10.26442/terarkh201890360-66DOI Listing
April 2018
2 Reads

Biomarkers of inflammatory bowel disease activity.

Ter Arkh 2018 Dec;90(12):107-111

A.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of Moscow, Moscow, Russia.

The review presents data on calprotectin, lactoferrin, leukocytes labeled with isotope indium 111In, calgranulin C and pyruvate kinase type M2 - highly sensitive biomarkers to assess the severity of intestinal inflammation. Their importance in diagnostics, determination of treatment efficiency, including as predictors of recurrence of ulcerative colitis and Crohn's disease is shown. Read More

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http://dx.doi.org/10.26442/00403660.2018.12.000018DOI Listing
December 2018
1 Read

Adherence to therapy of patients with inflammatory bowel diseases.

Ter Arkh 2018 Dec;90(12):4-11

A.S. Loginov Moscow Clinical Scientific Center of the Department of Health of Moscow, Moscow, Russia.

Inflammatory bowel diseases are autoimmune systemic forms of pathology. The concept of continuous life-long drug intake is a cornerstone in their therapy. The review presents the factors that reduce patients adherence to treatment and ways to improve it. Read More

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http://dx.doi.org/10.26442/00403660.2018.12.000001DOI Listing
December 2018
2 Reads

Ultrasound examination with contrast in the diagnosis of inflammatory bowel disease. The results of the pilot study.

Ter Arkh 2018 Feb;90(2):53-58

I. M. Sechenov First Moscow state medical University, Ministry of Health of Russia (Sechenovskiy University), Moscow, Russia.

Aim: Assessment of diagnostic significance of informativeness and security of ultrasonography with contrast enhancement drug SonoVue in the diagnosis of Crohn's disease (CD) and ulcerative colitis (UC).

Materials And Methods: The pilot conducted a prospective study which involved 15 patients with inflammatory bowel disease (IBD). All patients gave written consent to participate in the study and processing of personal data. Read More

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http://dx.doi.org/10.26442/terarkh201890253-58DOI Listing
February 2018
1 Read

Mesenchymal stromal cells of bone marrow and azathioprine in Crohn's disease therapy.

Ter Arkh 2018 Feb;90(2):47-52

S.A. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.

Aim: To evaluate the effectiveness of MSCs therapy in patients with CD receiving azathioprine (AZA).

Materials And Methods: The study included 34 patients with inflammatory (luminal) form of CD. The 1st group of patients (n=15) received an- ti-inflammatory therapy using MSCs culture in combination with AZA. Read More

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http://dx.doi.org/10.26442/terarkh201890247-52DOI Listing
February 2018

Personalized medicine in the treatment of inflammatory bowel diseases.

Ter Arkh 2018 Feb;90(2):4-11

S.A. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.

Personalized medicine (personalized medicine, individualized medicine) represents the totality of methods of prevention of a pathological condition, diagnosis and treatment in the event of its occurrence, based on individual patient characteristics. Such individual characteristics include genetic, epigenetic, and transcript, proteome, metabolomic and metagenomic markers, as well as a set of variable phenotypic traits - both of the patient's body and its separate tissues or cells. For example, treatment of inflammatory bowel diseases (IBD) can most clearly show the importance of applying personalized approaches. Read More

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http://ter-arkhiv.ru/en/archive/2018/vol-90-2-2018/personali
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http://dx.doi.org/10.26442/terarkh20189024-11DOI Listing
February 2018
4 Reads

Differentiating Crohn's disease from intestinal tuberculosis.

World J Gastroenterol 2019 Jan;25(4):418-432

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India.

Differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical (diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic (longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic (caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic (positive stain/culture for acid fast-bacillus in ITB), radiologic (long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus (AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However, these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. Read More

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http://dx.doi.org/10.3748/wjg.v25.i4.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350172PMC
January 2019
2 Reads

PentraSorb® CRP: Characterization of the selective C-reactive protein adsorber resin.

Ther Apher Dial 2019 Jan 29. Epub 2019 Jan 29.

Pentracor GmbH.

C-reactive protein (CRP) is well known as a general marker of inflammation. It furthermore represents a reliable risk factor for cardiac events and mediates tissue damage in acute myocardial infarction (AMI). It has been demonstrated that selective CRP depletion by extracorporeal apheresis in a porcine AMI model had beneficial effects on the infarcted area and the cardiac output. Read More

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http://doi.wiley.com/10.1111/1744-9987.12796
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http://dx.doi.org/10.1111/1744-9987.12796DOI Listing
January 2019
6 Reads

Vitamin D therapy in children with inflammatory bowel disease: A systematic review.

World J Clin Pediatr 2019 Jan 22;8(1):1-14. Epub 2019 Jan 22.

Department of Paediatrics, University of Otago Christchurch, Christchurch 8041, New Zealand.

Background: Vitamin D deficiency is highly prevalent in children with inflammatory bowel disease (IBD). This may contribute to an increased risk of poor bone health and may also influence the course of disease. An optimal treatment strategy of vitamin D therapy in children with IBD has not yet been established. Read More

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http://dx.doi.org/10.5409/wjcp.v8.i1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347665PMC
January 2019

High-intensity interval training and moderate-intensity continuous training in adults with Crohn's disease: a pilot randomised controlled trial.

BMC Gastroenterol 2019 Jan 29;19(1):19. Epub 2019 Jan 29.

Centre for Psychology and Sports Science, University of Hertfordshire, Life and Medical Sciences, CP Snow Building, College Lane, Hatfield, AL10 9AB, UK.

Background: This study assessed the feasibility and acceptability of two common types of exercise training-high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)-in adults with Crohn's disease (CD).

Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Read More

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http://dx.doi.org/10.1186/s12876-019-0936-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352351PMC
January 2019

Cohort Profile Update: The Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS).

Int J Epidemiol 2019 Jan 27. Epub 2019 Jan 27.

Division of Gastroenterology & Hepatology, Zurich University Hospital, Zurich, Switzerland.

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https://academic.oup.com/ije/advance-article/doi/10.1093/ije
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http://dx.doi.org/10.1093/ije/dyy298DOI Listing
January 2019
2 Reads
9.176 Impact Factor

Trends in the epidemiology of inflammatory bowel disease among Jewish Israeli adolescents: a population-based study.

Aliment Pharmacol Ther 2019 Mar 27;49(5):556-563. Epub 2019 Jan 27.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: The incidence and prevalence trends of inflammatory bowel disease (IBD) vary between developed and developing countries.

Aim: To investigate the prevalence and associated sociodemographic factors of IBD in Israeli Jewish adolescents METHODS: The files of the army medical corps were reviewed for adolescents recruited in 2002-2016 with confirmed IBD. Covariate data included birth date, patient and parental country of birth, number of children in the household, age at diagnosis, and socioeconomic status. Read More

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http://dx.doi.org/10.1111/apt.15160DOI Listing

Absence of dentate nucleus resting-state functional connectivity changes in nonneurological patients with gadolinium-related hyperintensity on T -weighted images.

J Magn Reson Imaging 2019 Jan 25. Epub 2019 Jan 25.

Departmental Faculty of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.

Background: The dentate nuclei of the cerebellum are the areas where gadolinium predominantly accumulates. It is not yet known whether gadolinium deposition affects brain functions.

Purpose/hypothesis: To assess whether gadolinium-dependent high signal intensity of the cerebellum on T -weighted images of nonneurological adult patients with Crohn's disease is associated with modifications of resting-state functional connectivity (RSFC) of the cerebellum and dentate nucleus. Read More

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http://dx.doi.org/10.1002/jmri.26669DOI Listing
January 2019
9 Reads

Hypoalbuminemia as a risk factor for thromboembolic events in inflammatory bowel disease inpatients.

Intest Res 2019 Jan 25;17(1):63-69. Epub 2019 Jan 25.

Gastroenterology Unit, Department of Internal Medicine, Department of Surgery, University of Campinas (UNICAMP), Campinas, Brazil.

Background/aims: Inflammatory bowel disease (IBD) are chronic entities characterized by local and systemic inflammation and may be associated with thrombosis. The aim of this study was to identify the prevalence of thromboembolic events (TEE) in hospitalized IBD patients and identify risk factors for their occurrence.

Methods: This retrospective, single-center study included patients treated at a Brazilian IBD referral unit between 2004 and 2014. Read More

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http://dx.doi.org/10.5217/ir.2018.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361029PMC
January 2019
1 Read

Cutaneous Crohn disease without gastrointestinal involvement in a 9-year-old boy.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

Cutaneous Crohn disease (CCD) is a rare dermatologic manifestation of Crohn disease and is defined as noncaseating, granulomatous skin lesions noncontiguous with the gastrointestinal tract. It most commonly affects the skin of the legs, although genital CCD is the most common presentation in children. Diagnosis of CCD is made by a combination of clinical and histopathological findings. Read More

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August 2018
5 Reads

Acneiform eruption induced by vedolizumab.

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Department of Dermatology, Consorcio Hospital General Universitario de Valencia, Valencia.

The development of new biological drugs for the treatment of advanced oncological processes or severe inflammatory diseases brings with it the appearance of new adverse effects. Vedolizumab, an α4β7 integrin inhibitor antibody, is approved for induction and maintenance therapy in both Crohn disease and ulcerative colitis. We report a case of severe acneiform eruption induced by vedolizumab in a 17-year-old woman with ulcerative colitis. Read More

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October 2018
2 Reads

Miliary Tuberculosis in a Crohn's Disease Patient: The Risk beyond the Screening.

GE Port J Gastroenterol 2018 Dec 13;26(1):64-69. Epub 2018 Mar 13.

Gastroenterology Department of Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.

Tumor necrosis factor alpha (TNFα) antagonist is recognized as an effective treatment to achieve clinical remission and healing mucosal in patients with moderate to severe active Crohn's disease. Considering that it plays a central role in immune-mediated modulation, there are some obvious concerns about its long-term safety. There is evidence that it may increase the risk of opportunistic infections such as tuberculosis, particularly reactivation of previous latent infection. Read More

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http://dx.doi.org/10.1159/000487297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341350PMC
December 2018
7 Reads

Impact of Modern Drug Therapy on Surgery: Crohn's Disease.

Authors:
Peter Kienle

Visc Med 2018 Dec 30;34(6):422-425. Epub 2018 Nov 30.

Department of Surgery, Theresienkrankenhaus und St. Hedwig-Klinik GmbH, Mannheim, Germany.

Background: A significant number of patients with Crohn's disease needs to undergo surgery, and many of these patients are under modern drug treatment. These drugs may influence the rate of perioperative complications. This may have an impact on the chosen surgical strategy. Read More

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http://dx.doi.org/10.1159/000495127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341356PMC
December 2018

Regional variations in the use of biologics and immunomodulators among Korean patients with inflammatory bowel diseases.

J Gastroenterol Hepatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Biostatistics, Graduate School of Public Health, Yonsei University, Seoul, Korea.

Background And Aim: Variation in medical care can be an obstacle to improving quality and outcome of treatment. We conducted a nationwide, population-based study to identify regional variations in medication prescription rates in Korean patients with inflammatory bowel diseases (IBDs).

Methods: Using the National Health Insurance claims, we collected data on patients diagnosed with IBD (8974 cases of Crohn's disease [CD] and 17 167 cases of ulcerative colitis [UC]) between 2010 and 2016. Read More

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http://dx.doi.org/10.1111/jgh.14609DOI Listing
January 2019
2 Reads

Meckel's Diverticulum Diagnosed in a Child with Suspected Small Bowel Crohn's Disease.

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):98-104. Epub 2019 Jan 10.

Department of Pediatrics, Jeju National University School of Medicine, Jeju, Korea.

We report a rare case of Meckel's diverticulum in a boy who initially presented with chronic iron deficiency anemia (IDA) without any history of gastrointestinal (GI) bleeding at 8 years-old. Isolated small bowel Crohn's disease was suspected based on findings of small bowel ulcers on capsule endoscopy. At four years from initial presentation, he developed massive GI bleeding. Read More

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http://dx.doi.org/10.5223/pghn.2019.22.1.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333590PMC
January 2019
1 Read

Enterourachal Fistula as an Initial Presentation in Crohn Disease.

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):90-97. Epub 2019 Jan 10.

Division of Pediatric Gastroenterology, Department of Pediatrics, UH Rainbow Babies & Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, United States.

Crohn disease has a wide spectrum of clinical presentations and rarely can present with complications such as a bowel stricture or fistula. In this case report, we describe a 17-year-old male who presented with a history of recurrent anterior abdominal wall abscesses and dysuria. He was diagnosed with Crohn disease and also found to have a fistulous communication between the terminal ileum and a patent urachus. Read More

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http://dx.doi.org/10.5223/pghn.2019.22.1.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333586PMC
January 2019
6 Reads

Therapeutic Efficacy of Exclusive Enteral Nutrition with Specific Polymeric Diet in Pediatric Crohn's Disease.

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):72-79. Epub 2019 Jan 10.

Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The efficacy of exclusive enteral nutrition (EEN) with a polymeric diet has not been confirmed in Korean pediatric patients with Crohn's disease (CD). This study aimed to compare the effectiveness of EEN with a specific polymeric diet (Encover®) and corticosteroids (CSs) for the induction of remission in Korean pediatric CD patients.

Methods: We retrospectively compared data from 51 pediatric CD patients who underwent induction therapy with EEN (n=19) or CSs (n=32) at Severance Children's Hospital or Incheon St. Read More

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http://dx.doi.org/10.5223/pghn.2019.22.1.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333584PMC
January 2019
4 Reads

Clinical Aspects and Treatments for Pediatric Inflammatory Bowel Diseases.

Authors:
Jin Soo Moon

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):50-56. Epub 2019 Jan 10.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

The incidence of pediatric inflammatory bowel disease (IBD) is increasing worldwide, especially in the developing countries. It differs from adult disease in clinical manifestations, especially with regard to genetic predisposition in monogenic IBD. Pediatric disease also have a tendency to show more aggressive inflammation and greater extent of lesion. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5223/pghn.2019.2
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http://dx.doi.org/10.5223/pghn.2019.22.1.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333592PMC
January 2019
3 Reads

Successful Transition from Pediatric to Adult Care in Inflammatory Bowel Disease: What is the Key?

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):28-40. Epub 2019 Jan 10.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

The incidence of pediatric-onset inflammatory bowel disease (IBD) is on the rise, accounting for up to 25% of IBD cases. Pediatric IBD often has extensive bowel involvement with aggressive and rapidly progressing behavior compared to adult IBD. Because IBD has a high morbidity rate and can have a lifelong impact, successful transition from pediatric to adult care is important to maintain the continuity of care. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5223/pghn.2019.2
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http://dx.doi.org/10.5223/pghn.2019.22.1.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333582PMC
January 2019
5 Reads

The Crohn's disease polymorphism, T300A, alters the gut microbiota and enhances the local Th1/Th17 response.

Elife 2019 Jan 22;8. Epub 2019 Jan 22.

Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States.

Inflammatory bowel disease (IBD) is driven by dysfunction between host genetics, the microbiota, and immune system. Knowledge gaps remain regarding how IBD genetic risk loci drive gut microbiota changes. The Crohn's disease risk allele T300A results in abnormal Paneth cells due to decreased selective autophagy, increased cytokine release, and decreased intracellular bacterial clearance. Read More

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http://dx.doi.org/10.7554/eLife.39982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342529PMC
January 2019
1 Read

Long Noncoding RNA Antisense Noncoding RNA in the INK4 Locus Correlates With Risk, Severity, Inflammation and Infliximab Efficacy in Crohn's Disease.

Am J Med Sci 2019 Feb 22;357(2):134-142. Epub 2018 Nov 22.

Department of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of TCM, Zhejiang International Exchange Center of Clinical TCM, Hangzhou, China. Electronic address:

Background: The aim of this study was to investigate the association of intestinal mucosa long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL) expression with disease risk, activity and inflammatory cytokines levels of Crohn's disease (CD).

Methods: Forty-two patients with active CD (A-CD), 59 patients with CD in remission (R-CD) and 67 controls were consecutively recruited. Intestinal mucosa samples were collected from all participants at baseline and from A-CD patients at 3-months after infliximab treatment. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.10.016DOI Listing
February 2019
3 Reads

Inflammatory bowel disease and bipolar disorder: A population-based cross-sectional study.

J Affect Disord 2019 Mar 15;247:120-124. Epub 2019 Jan 15.

Department of Psychiatry, Taipei Medical University-Shuang-Ho Hospital, New Taipei City, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background: To date, some experimental studies showed that inflammatory bowel disease (IBD) and bipolar disorder (BD) may share similar biological pathways. Nevertheless, only a few western studies have attempted to demonstrate the potential association between IBD and BD, and relevant findings are still conflicting. Therefore, this cross-sectional study aimed to evaluate the relationship between IBD and BD using a nationwide database in Taiwan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183248
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http://dx.doi.org/10.1016/j.jad.2019.01.014DOI Listing
March 2019
7 Reads

What is the outcome for patients undergoing more than two ileocolonic resections for recurrent Crohn's disease? A comparative study of 569 consecutive procedures.

Colorectal Dis 2019 Jan 19. Epub 2019 Jan 19.

Department of Colorectal Surgery, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, (AP-HP), University Denis Diderot (Paris VII), Clichy, France.

Aim: To assess the outcome for patients undergoing repeated ileocolonic resection for recurrent Crohn's disease (CD).

Method: All patients undergoing ileocolonic resection for terminal ileal CD between 1998 and 2016 in our tertiary care centre were retrospectively reviewed.

Results: Between 1998 and 2016, 569 ileocolonic resections were performed for CD: 403 of these were primary resections (1R, 71%), 107 second resections (2R, 19%) and 59 were third (or more) resections (> 2R, 10%). Read More

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http://dx.doi.org/10.1111/codi.14562DOI Listing
January 2019
4 Reads

Therapeutic uses of metronidazole and its side effects: an update.

Eur Rev Med Pharmacol Sci 2019 Jan;23(1):397-401

Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Ex Hacienda, Pachuca de Soto Hidalgo, México.

Objective: Metronidazole is an antibiotic widely used in different medical conditions such as trichomoniasis, amoebiasis, and giardiasis among others. Its use has been associated with toxicity; however, it is not well characterized. In this review, we discuss the different therapeutic uses of metronidazole and its side effects in order to aid future investigation in this field. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16788DOI Listing
January 2019
2 Reads

Capsule endoscopy for small-intestinal disorders: Current status.

Dig Endosc 2019 Jan 17. Epub 2019 Jan 17.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Small-bowel capsule endoscopy (SBCE) is used widely because of its non-invasive and patient-friendly nature. SBCE can visualize entire small-intestinal mucosa and facilitate detection of small-intestinal abnormalities. In this review article, we focus on the current status of SBCE. Read More

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http://doi.wiley.com/10.1111/den.13346
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http://dx.doi.org/10.1111/den.13346DOI Listing
January 2019
6 Reads

Genetic variants of SMAD2/3/4/7 are associated with susceptibility to ulcerative colitis in a Japanese genetic background.

Immunol Lett 2019 Jan 14. Epub 2019 Jan 14.

Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto-machi, Nagasaki 852-8102, Japan.

Purpose: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is attributed to inappropriate inflammatory response in intestinal mucosa. Transforming growth factor β (TGF-β)/SMAD signaling plays key role in differentiation of naïve CD4 T cells to T helper 17 (Th17) cells or regulatory T (T) cells. This study aimed to investigate associations between single nucleotide polymorphisms (SNPs) of SMAD family genes and susceptibility to IBD in a Japanese cohort to elucidate genetic determinants of IBD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183053
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http://dx.doi.org/10.1016/j.imlet.2019.01.007DOI Listing
January 2019
4 Reads