46,238 results match your criteria Crohn Disease


Olmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats.

Drug Deliv 2022 Dec;29(1):2017-2028

Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Olmesartan medoxomil (OM) is an angiotensin receptor blocker. This study aimed to investigate the effects of OM self-microemulsifying drug delivery system (OMS) in trinitrobenzene sulfonic acid (TNBS)-induced acute colitis in rats. Besides two control groups, five TNBS-colitic-treated groups ( = 8) were given orally sulfasalazine (100 mg/kg/day), low and high doses of OM (3. Read More

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December 2022

[Effectiveness of induction therapy with exclusive enteral nutrition in pediatric Crohn's disease].

Zhongguo Dang Dai Er Ke Za Zhi 2022 Jun;24(6):626-630

Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310052, China.

Objectives: To evaluate the effectiveness of induction therapy with exclusive enteral nutrition (EEN) in pediatric Crohn's disease (CD).

Methods: A retrospective analysis was performed on the medical data of 62 children with CD who received EEN in Children's Hospital, Zhejiang University School of Medicine, from March 2013 to August 2021. The medical data included general information and height, weight, Pediatric Crohn's Disease Activity Index (PCDAI), Crohn's Disease Endoscopic Index of Severity, C-reactive protein, erythrocyte sedimentation rate, and serum albumin level before treatment and after 8 weeks of treatment. Read More

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High-dimensional profiling reveals Tc17 cell enrichment in active Crohn's disease and identifies a potentially targetable signature.

Nat Commun 2022 Jun 27;13(1):3688. Epub 2022 Jun 27.

Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.

The immune-pathology in Crohn's disease is linked to dysregulated CD4+ T cell responses biased towards pathogenic TH17 cells. However, the role of CD8+ T cells able to produce IL-17 (Tc17 cells) remains unclear. Here we characterize the peripheral blood and intestinal tissue of Crohn's disease patients (n = 61) with flow and mass cytometry and reveal a strong increase of Tc17 cells in active disease, mainly due to induction of conventional T cells. Read More

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A giant polyp in a filiform polyposis hides Crohn's disease.

Dig Liver Dis 2022 Jun 24. Epub 2022 Jun 24.

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

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Prophylactic Antitubercular Therapy Is Associated With Accelerated Disease Progression in Patients With Crohn's Disease Receiving Anti-TNF Therapy: A Retrospective Multicenter Study.

Clin Transl Gastroenterol 2022 Jun 1;13(6):e00493. Epub 2022 Jun 1.

Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Introduction: Prophylactic antitubercular therapy (ATT) is widely prescribed in patients with Crohn's disease (CD) receiving antitumor necrosis factor (anti-TNF) treatment. However, antitubercular agents have been demonstrated to possess profibrotic effects. We aimed to evaluate whether ATT accelerated disease progression in patients with CD receiving anti-TNF treatment. Read More

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LARGE INTESTINE OBSTRUCTION CAUSED BY PSEUDOPOLYPOSIS IN THE COURSE OF ULCERATIVE COLITIS - A CASE REPORT.

Wiad Lek 2022 ;75(5 pt 2):1415-1417

SOLEC HOSPITAL, WARSAW, POLAND.

Ulcerative colitis is an inflammatory bowel disease. Opposite to Crohn's disease, it affects only the mucosa and submucosa of the large intestine. The disease can have episodes of flares and remissions. Read More

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Histologic Features of Clostridioides difficile Colitis in Patients with Inflammatory Bowel Disease.

Histopathology 2022 Jun 27. Epub 2022 Jun 27.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Aims: Patients with inflammatory bowel disease (IBD) are at increased risk for Clostridioides difficile infection, although clinically important infections can be difficult to recognize. C. difficile infection does not produce pseudomembranes when it occurs in IBD patients. Read More

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Causal Association Between Inflammatory Bowel Disease and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study.

Front Immunol 2022 10;13:916645. Epub 2022 Jun 10.

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Background: Previous observational studies have found an association between inflammatory bowel disease (IBD) and psoriasis. Using the mendelian randomization (MR) approach, we aim to determine whether there was a causal association between IBD and psoriasis.

Methods: We performed a two-sample MR with the genetic instruments identified for IBD and its main subtypes, Crohn's disease (CD) and ulcerative colitis (UC), from a genome-wide association study (GWAS) involving 25,042 cases with an IBD diagnosis and 34,915 controls. Read More

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Clinical value of the expression levels of protein tyrosine phosphatase non-receptor type 22.6 mRNA in peripheral blood mononuclear cells in Crohn's disease.

Clin Exp Immunol 2022 Jun 25. Epub 2022 Jun 25.

Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory for Molecular Diagnosis of Hubei Province, Wuhan 430014, China.

Objective: To explore the relationship between the expression levels of protein tyrosine phosphatase non-receptor type (PTPN) 22.6 mRNA in peripheral blood mononuclear cells (PBMCs) and the disease activity as well as clinical characteristics in Crohn's disease (CD) patients.

Methods: A total of 480 subjects were enrolled. Read More

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Surgical Management of Enterovesical Fistula in Crohn's Disease in the Biologic Era.

Inflamm Bowel Dis 2022 Jun 25. Epub 2022 Jun 25.

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

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Endoscopic features and clinical course of patients with asymptomatic cecal ulcers.

BMC Gastroenterol 2022 Jun 24;22(1):309. Epub 2022 Jun 24.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Xitun Dist., Taichung City, 40705, Taiwan.

Background: Cecal ulcers are sometimes encountered in asymptomatic individuals. Their clinical outcomes and management recommendations remain uncertain.

Methods: Asymptomatic patients who underwent a colonoscopic exam for colon cancer screening were retrospectively reviewed from July 2009 to November 2016. Read More

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Dermoscopy in the diagnosis and assessment of treatment response in granulomatous cheilitis.

BMJ Case Rep 2022 06 24;15(6). Epub 2022 Jun 24.

Dermatology Venereology and Leprosy, Shri BM Patil Medical College, Vijayapur, Karnataka, India

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"Out of the box" new therapeutic strategies for Crohn´s disease: moving beyond biologics.

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Gastroenterology, Stavanger University Hospital.

New treatment options beyond immunosuppression have emerged in recent years for patients with Crohn´s disease (CD), a chronic systemic condition affecting primarily the gut with great impact in the quality of life. The cause of CD is largely unknown, and a curative treatment is not yet available. In addition, despite the growing therapeutic armamentarium in recent years almost half of the patients don´t achieve a sustained response over time. Read More

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Diagnostic Value of Quantitative Contrast-Enhanced Ultrasound in Comparison to Endoscopy in Children with Crohn's Disease.

J Ultrasound Med 2022 Jun 24. Epub 2022 Jun 24.

Department of Radiology, Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Objective: Quantitative contrast-enhanced US (CEUS) provides objective evaluation of bowel wall perfusion and has been reported as a useful method for evaluating Crohn's disease (CD) activity in children. We tested its' diagnostic accuracy in comparison to endoscopy and evaluated its' usefulness in comparison to Pediatric Crohn's Disease Activity Index (PCDAI) and fecal Calprotectin (FC).

Materials And Methods: Children with CD and thickened bowel wall on abdominal US were prospectively enrolled. Read More

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Retroperitoneal and iliopsoas abscess as Crohn's disease onset mimicking a common lumbosciatic pain.

Ann Ital Chir 2022 Jun 15;11. Epub 2022 Jun 15.

Crohn's Disease (CD) refers to a chronic transmural bowel inflammation affecting a range between 5 and 15 per 100,000 person-years worldwide 1. In patients with stricturing CD, the transmural pattern of inflammation may trigger the development of sinus tracts able to connect to other tissues, leading to the formation of fistulas or abscesses 2. Intra-psoas abscesses are rare, affecting between 0. Read More

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Initial Abdominal CT and Laboratory Findings Prior to Diagnosis of Crohn's Disease in Children.

Yonsei Med J 2022 Jul;63(7):675-682

Department of Radiology, Research Institute of Radiological Science, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.

Purpose: To identify initial abdominal computed tomography (CT) and laboratory findings prior to a diagnosis of Crohn's disease (CD) in children.

Materials And Methods: In this retrospective study, patients (≤18 year-old) who were diagnosed with CD from 2004 to 2019 and had abdominal CT just prior to being diagnosed with CD were included in the CD group. Patients (≤18 years old) who were diagnosed with infectious enterocolitis from 2018 to 2019 and had undergone CT prior to being diagnosed with enterocolitis were included as a control group. Read More

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Laparoscopic management of Crohn's disease-related complex enterovesical, enterocutaneous and enteroenteric fistula: A case report.

Asian J Endosc Surg 2022 Jun 23. Epub 2022 Jun 23.

Department of Medical Gastroenterology, Bangalore Medical College, Bangalore, India.

The management of Crohn's disease is medical, with surgery reserved for emergencies and complications. Fistulizing Crohn's disease can present with either an internal or external fistula. Internal fistulae are common in patients with ileocolonic disease. Read More

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Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease.

Nutrients 2022 Jun 17;14(12). Epub 2022 Jun 17.

Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

Diet plays an important role in the development and progression of inflammatory bowel disease (IBD, comprising Crohn's disease (CD) and ulcerative colitis (UC)). However, little is known about the extent to which different diets reflect inflammation in IBD beyond measures such as faecal calprotectin or C-reactive protein. In this study, we aimed to unravel associations between dietary patterns and circulating inflammatory proteins in patients with IBD. Read More

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Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota-A Narrative Review.

Nutrients 2022 Jun 17;14(12). Epub 2022 Jun 17.

Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznań, Poland.

Despite the increasing knowledge with regard to IBD (inflammatory bowel disease), including ulcerative colitis (UC) and Crohn's disease (CD), the etiology of these conditions is still not fully understood. Apart from immunological, environmental and nutritional factors, which have already been well documented, it is worthwhile to look at the possible impact of genetic factors, as well as the composition of the microbiota in patients suffering from IBD. New technologies in biochemistry allow to obtain information that can add to the current state of knowledge in IBD etiology. Read More

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Crohn's Disease and Female Infertility: Can Nutrition Play a Supporting Role?

Nutrients 2022 Jun 10;14(12). Epub 2022 Jun 10.

Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.

Crohn's disease (CD) is a chronic inflammatory disease (IBD) that can affect the entire gastrointestinal tract in a non-continuous mode. CD is generally diagnosed most commonly between 15 and 35 years of age and may affect female fertility. The role of diet in supporting wellbeing outcome and reproductive potential in women is well-known; however, no effective efforts have been made to improve women's awareness in CD. Read More

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Potential Composite Digenic Contribution of and Leading to Atypical Lethal Niemann-Pick Type C with Initial Crohn's Disease-like Presentation: Genotype-Phenotype Correlation Study.

Genes (Basel) 2022 May 29;13(6). Epub 2022 May 29.

Pediatric Department, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Niemann-Pick disease type C (NPC) is an autosomal recessive neurovisceral disease characterized by progressive neurodegeneration with variable involvement of multisystemic abnormalities. Crohn's disease (CD) is an inflammatory bowel disease (IBD) with a multifactorial etiology influenced by variants in . Here, we investigated a patient with plausible multisystemic overlapping manifestations of both NPC and CD. Read More

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Role of Dual Energy Computed Tomography in Inflammatory Bowel Disease.

Semin Ultrasound CT MR 2022 Aug 1;43(4):320-332. Epub 2022 Apr 1.

Department of Radiology, Massachusetts General Hospital, Boston, MA. Electronic address:

Dual-energy computed tomography (DECT), which allows material-based differential X-ray absorption behavior from near simultaneously acquired low- and high-kilovolt datasets is finding increasing applications in the evaluation of bowel diseases. In patients with inflammatory bowel disease, DECT techniques permit both qualitative and quantitative assessment. Particularly in patients with Crohn's disease, monoenergetic and iodine specific images have been explored. Read More

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Title: Consensus Guidelines on the Nutritional Assessment and Dietary Management of Patients with Inflammatory Bowel Disease (IBD).

J Hum Nutr Diet 2022 Jun 23. Epub 2022 Jun 23.

Department of Nutritional Sciences, King's College London, London, UK.

Background: Despite increased awareness of diet and nutrition being integral to the management of patients with inflammatory bowel disease (IBD), there are gaps in the knowledge of IBD healthcare providers regarding nutrition. Furthermore, high quality evidence on nutritional assessment and dietary management of IBD is limited. A Delphi Consensus from a panel of experts allows for best-practice guidelines to be developed, especially where high quality evidence is limited. Read More

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Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease.

Front Immunol 2022 6;13:865777. Epub 2022 Jun 6.

Translational Type 1 Diabetes Research, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflammatory cascades and affect the extracellular matrix, tight junctions, cellular hemostasis, and microbiota. Read More

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Inflammatory markers may predict post-operative complications and recurrence in Crohn's disease patients undergoing gastrointestinal surgery.

ANZ J Surg 2022 Jun 22. Epub 2022 Jun 22.

Department of Surgery and Transplantations B, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

Background: Most Crohn's Disease (CD) patients will require surgical intervention over their lifetime, with considerably high rates of post-operative complications. Risk stratification with reliable prognostic tools may facilitate clinical decision making in these patients. Blood cell interaction based inflammatory markers have proven useful in predicting patient outcomes in oncological and benign diseases. Read More

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Symptoms associated with healthcare resource utilization in the setting of inflammatory bowel disease.

Sci Rep 2022 Jun 22;12(1):10577. Epub 2022 Jun 22.

Department of Medicine, Division of Gastroenterology and Hepatology, Pennsylvania State University College of Medicine, 500 University Drive, M.C. HU33, Hershey, PA, 17033, USA.

Several symptoms have been connected to increased healthcare resource utilization (HRU) in the context of inflammatory bowel disease (IBD), including both Crohn's disease (CD) and ulcerative colitis (UC). This study was designed to investigate the prevalence of IBD-associated symptoms and to determine whether any are independently associated with HRU. We undertook a retrospective analysis of data related to consecutive IBD patient encounters from a tertiary care referral center between 1/1/2015 and 8/31/2019. Read More

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Crohn's Disease Is Associated with Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.

Dig Dis Sci 2022 Jun 22. Epub 2022 Jun 22.

Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: Chronic inflammation in IBD is postulated to drive NAFLD progression from steatosis to fibrosis.

Aims: To study the histopathological spectrum of NAFLD in Crohn disease (CD) and Ulcerative colitis (UC).

Methods: Patients with biopsy proven NAFLD at a quaternary center from 2008 to 2018 were included in this retrospective analysis. Read More

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Evaluation of insulin resistance and beta cell activity in patients with inflammatory bowel disease.

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):3989-3994

Department of Internal Medicine, Hisar Intercontinental Hospital, İstanbul, Turkey.

Objective: Insulin resistance is an important risk factor for developing metabolic syndromes that cause morbidity diseases such as diabetes and cardiovascular diseases. Interestingly, in chronic inflammatory diseases, some inflammatory mediators can play, either directly or indirectly, a pivot role in the development of insulin resistance. This can be considered as an additional factor causing increased mortality and morbidity in these patients. Read More

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INFLAMMATORY BOWEL DISEASES: CHARACTERISTICS, EVOLUTION, AND QUALITY OF LIFE.

Arq Bras Cir Dig 2022 17;35:e1653. Epub 2022 Jun 17.

Santa Marcelina Hospital , Coloproctology Unit- São Paulo - SP - Brazil.

Aim: Inflammatory bowel diseases present progressive and potentially debilitating characteristics with an impact on health-related quality of life (QoL) throughout the course of the disease, and this parameter may even be used as a method of evaluating response to treatment. The aim of this study was to analyze epidemiological data, medications in use, previous surgeries, and hospitalizations in patients with inflammatory bowel diseases, and to determine the impairment in QoL of these patients.

Methods: This is a prospective, cross-sectional, observational study in patients with inflammatory bowel disease followed up in a tertiary hospital in São Paulo-SP, Brazil. Read More

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Clinical course of inflammatory bowel disease and impact on liver disease outcomes in patients with autoimmune sclerosing cholangitis.

Clin Res Hepatol Gastroenterol 2022 Jun 18:101980. Epub 2022 Jun 18.

Department of Gastroenterology, King's College Hospital, London, UK; King's College London, UK.

Background & Aims: Autoimmune sclerosing cholangitis (ASC) is a childhood sclerosing cholangitis frequently associated with inflammatory bowel disease (IBD). We describe the IBD phenotype in ASC patients and associated liver disease outcomes.

Methods: Single centre retrospective observational review of ASC patients, with a control population of paediatric IBD. Read More

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