38,918 results match your criteria Crohn Disease
Front Immunol 2018 21;9:2679. Epub 2018 Nov 21.
Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
Antibody class switch recombination (CSR) to IgG, IgA, or IgE is a hallmark of adaptive immunity, allowing antibody function diversification beyond IgM. CSR involves a deletion of the IgM/IgD constant region genes placing a new acceptor Constant gene, downstream of the VDJ exon. CSR depends on non-coding (CSRnc) transcription of donor I and acceptor I exons, located 5' upstream of each C coding gene. Read More
Intest Res 2018 Dec 3. Epub 2018 Dec 3.
Department of Paediatrics, University of Otago Christchurch, Christchurch, New Zealand.
The role and efficacy of exclusive enteral nutrition (EEN) in the treatment of luminal Crohn's disease (CD) has been well established over the last 2 decades. Consequently, in many centers nutritional therapy is now considered first line therapy in the induction of remission of active CD. However, the use of nutritional therapy in complicated CD has yet to be fully determined. Read More
Intest Res 2018 Dec 3. Epub 2018 Dec 3.
Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Background/aims: Few reports have described the long-term treatment outcomes of the anti-tumor necrosis factor-α antibody for Japanese Crohn's disease (CD) patients. The aim of this study was to evaluate them and clarify the clinical factors that affect the long-term prognosis of the anti-tumor necrosis factor-α treatments.
Methods: This was a retrospective, observational, single-center cohort study. Read More
Colorectal Dis 2018 Dec;20 Suppl 8:3-117
Western General Hospital, Edinburgh, UK.
Aim: There is a requirement of an expansive and up to date review of surgical management of inflammatory bowel disease (IBD) that can dovetail with the medical guidelines produced by the British Society of Gastroenterology.
Methods: Surgeons who are members of the ACPGBI with a recognised interest in IBD were invited to contribute various sections of the guidelines. They were directed to produce a procedure based document using literature searches that were systematic, comprehensible, transparent and reproducible. Read More
Inflamm Intest Dis 2018 Nov 4;3(1):40-42. Epub 2018 Oct 4.
Department of Biostatistics, Lenox Hill Hospital, New York, New York, USA.
Objective: To seek the habits of pediatricians by which anorectal skin tags (AST) of Crohn's disease might be overlooked.
Methods: Questionnaires were sent to pediatricians affiliated with the Northwell Health System.
Results: Based on the responses, the majority of pediatricians did feel the abdomen of children presenting with abdominal pain or diarrhea but did not spread the buttocks to seek the presence of AST unless there was rectal pain, rectal bleeding, or, in some cases, loose stools. Read More
Inflamm Intest Dis 2018 Nov 17;3(1):32-39. Epub 2018 Sep 17.
Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Background: The aim of this study was to describe the incidence of inflammatory bowel disease (IBD) and changes in demographic and phenotypic disease presentation in Otago, New Zealand.
Methods: This study was conducted at Dunedin Hospital and the study period was 1996-2013. Otago residents diagnosed with IBD were identified retrospectively from hospital lists using ICD-10 codes. Read More
Inflamm Intest Dis 2018 Nov 5;3(1):25-31. Epub 2018 Oct 5.
Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Background: Inflammatory bowel disease (IBD), though historically common in the West, is now increasingly prevalent in industrializing countries. A simultaneous dramatic increase in IBD drug options has enabled most patients to achieve remission. Nevertheless, worldwide disparities in the approval of IBD drugs, or "drug lag", remain problematic. Read More
Inflamm Intest Dis 2018 Nov 12;3(1):11-15. Epub 2018 Jul 12.
Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Background: Patients with moderate-severe inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are commonly treated with long-term immunosuppressive therapies involving immunomodulators such as thiopurines, biologics (anti-TNF and anti-adhesion molecules), or novel small molecules such as Janus kinase inhibitors.
Summary: Some infections seen with immunosuppressive therapy in IBD are preventable with vaccines. IBD-specific immunosuppressive therapy is generally initiated by gastroenterologists. Read More
J Immunol 2018 Nov 30. Epub 2018 Nov 30.
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1081AZ Amsterdam, the Netherlands;
Innate lymphoid cells (ILCs) guard epithelial tissue integrity during homeostasis, but can be potent immune effector cells during inflammation. Precursors to all ILC subsets (ILC precursors [ILCP]) have been identified in human peripheral blood (PB). We found that during homeostasis, ILCP in PB of mouse and human expressed homing receptors for secondary lymphoid organs, mainly CD62L. Read More
Nephrol Ther 2018 Nov 29. Epub 2018 Nov 29.
Laboratoire d'anatomie pathologique, CHRU de Nancy, 5, rue de Morvan, 54500 Vandœuvre-lès-Nancy, France.
Extraintestinal manifestations in inflammatory bowel disease involve most frequently the joints, the skin, the eyes, the liver and the biliary tract. Renal involvement is rare, and manifested as nephrolithiasis, tubulointerstitial nephritis, glomerulonephritis and amyloidosis. In patients with inflammatory bowel disease, renal disease is most frequently due to treatment nephrotoxicity and rarely as a guenine extraintestinal manifestation of inflammatory bowel disease. Read More
Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.
Servicio de Medicina del Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
There are many useful biomarkers for initial diagnosis and the management of inflammatory bowel disease. Serologic biomarkers have been traditionally used because they are widely disposable, but recently faecal biomarkers, especially faecal calprotectin, have acquired great importance as they have shown to be more precise when establishing suspicion of the disease and also as predictors of mucosal healing or persistence of inflammatory activity. Faecal calprotectin is a good tool for predicting abnormal endoscopic studies, but has limited specificity because its levels can be altered in many digestive diseases presenting with similar symptoms. Read More
J Dig Dis 2018 Dec 5. Epub 2018 Dec 5.
Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease, Shanghai, China.
Objective: Methotrexate (MTX) can be used as an alternative for Crohn's disease (CD) patients intolerant to thiopurine. Although some studies have reported the efficacy of MTX administration in treating CD, few studies have included Asian patients. This retrospective study aimed to provide some clues regarding MTX treatment in Chinese CD patients. Read More
PLoS One 2018 29;13(11):e0207996. Epub 2018 Nov 29.
UNED IR & NLP Group, Madrid, Spain.
Introduction: Exploiting information in health-related social media services is of great interest for patients, researchers and medical companies. The challenge is, however, to provide easy, quick and relevant access to the vast amount of information that is available. One step towards facilitating information access to online health data is opinion mining. Read More
JGH Open 2018 Oct 17;2(5):201-206. Epub 2018 Jul 17.
Division of Gastroenterology, Department of Medicine, Zane Cohen Center, Mount Sinai Hospital University of Toronto Toronto Ontario Canada.
Background: The utility of fecal calprotectin (FC) in small intestinal Crohn's disease (CD) is unclear. We examined how reliably FC reflects clinical and mucosal disease activity in small intestinal CD, colonic CD, and ulcerative colitis (UC).
Methods: A total of 72 Inflammatory Bowel Disease (IBD) patients (23 colonic CD, 14 isolated small intestinal CD, and 35 UC) were included. Read More
JGH Open 2018 Feb 5;2(1):15-20. Epub 2018 Feb 5.
Gastroenterology Unit, Faculty of Medicine Alexandria University Alexandria Egypt.
Background And Aim: Despite being in remission, functional gastrointestinal disease (FGID) in Crohn's disease (CD) patients can reduce their quality of life. The Egyptian daily diet contains a high amount of FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, And Polyols). As the low FODMAP diet has been proven to be effective in irritable bowel syndrome worldwide, it was reasonable to take a step further and begin to study the effect of low FODMAP in Egyptian CD patients with FGID. Read More
JGH Open 2018 Feb 4;2(1):8-14. Epub 2018 Jan 4.
Department of Gastroenterology The Alfred Hospital Melbourne Victoria Australia.
Background And Aim: A proportion of patients having total proctocolectomy and ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) are later diagnosed with Crohn's disease (CD). The aim of this study was to identify preoperative and perioperative predictors for the subsequent development of CD in patients who had IPAA for presumed UC.
Methods: A retrospective case-control study of patients undergoing IPAA surgery for presumed UC was undertaken. Read More
Front Med (Lausanne) 2018 13;5:318. Epub 2018 Nov 13.
Internal Medicine, Gastroenterology and Hepatic Diseases Unit, Gastroenterological Area, Gastroenterological and Endocrino-Metabolical Sciences Department, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
Front Pediatr 2018 12;6:338. Epub 2018 Nov 12.
Unit of Pediatrics and Adolescentology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
We proposed to verify the role of growth hormone receptor gene expression in growth failure of children with Crohn's disease (CD). We measured serum levels of growth hormone binding protein (GHBP) and insulin-like growth factor-I (IGF-I), and growth hormone receptor (GHR) gene expression in peripheral blood mononuclear cells of 21 patients with CD (before and after therapy) and in 27 age-sex-matched controls. At diagnosis, significantly lower insulin-like growth factor-I and growth hormone binding protein levels were found in the CD group compared to the controls. Read More
Case Rep Gastroenterol 2018 Sep-Dec;12(3):608-616. Epub 2018 Oct 17.
Medical School, Department of Internal Medicine, São Paulo State University (UNESP), Botucatu, Brazil.
Inflammatory bowel disease (IBD) affects young people of reproductive age. Therefore, a broad discussion is needed about the possible disease effects in pregnancy, as well as the risks of fetal exposure to the medications used, especially biological therapy. This study aimed to describe the management of 4 Crohn's disease patients who received anti-TNF therapy during pregnancy and present a literature review. Read More
J Med Internet Res 2018 Nov 27;20(11):e11602. Epub 2018 Nov 27.
Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain.
Background: The reported efficacy of telemedicine in patients with inflammatory bowel disease (IBD) is inconsistent among studies, and data for complex IBD are lacking.
Objective: We aimed to evaluate the impact of remote monitoring using a Web system-Telemonitorización de la Enfermedad de Crohn y Colitis Ulcerosa or Telemonitoring of Crohn's Disease and Ulcerative Colitis (TECCU)-as compared to standard care and telephone care on health outcomes and health care in patients with complex IBD.
Methods: We performed a 3-arm randomized controlled trial. Read More
GE Port J Gastroenterol 2018 Nov 13;25(6):322-326. Epub 2018 Feb 13.
Gastroenterology Department, Hospital da Senhora da Oliveira, Guimarães, Portugal.
Common variable immunodeficiency (CVID) is the most frequent form of immunodeficiency in adults. Clinical manifestations are heterogeneous with an increased susceptibility to infections and inflammatory conditions, namely autoimmune diseases, such as inflammatory bowel disease. We present the clinical case of a Caucasian female patient, 21 years old, with a past medical history of CVID, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Read More
Clin Gastroenterol Hepatol 2018 Nov 21. Epub 2018 Nov 21.
Division of Gastroenterology & Hepatology, Lausanne University Hospital, Lausanne, Switzerland; Crohn and Colitis Center, Gastroentérologie Beaulieu SA, Lausanne, Switzerland.
Background & Aims: Inflammatory bowel disease (IBD) scoring systems combine patient-reported data with physicians' observations to determine patient outcomes, but these systems are believed to have limitations. We used real-world data from a large IBD cohort in Switzerland to compare results between patients and healthcare professionals' from scoring systems for Crohn's disease (CD) and ulcerative colitis (UC).
Methods: We collected data from the Swiss IBD cohort, beginning in 2006, using 2453 reports for 1385 patients (52% female, 58% with CD). Read More
Am Health Drug Benefits 2018 Jul;11(5):253-262
Head of GI Global Outcomes Research, Takeda Pharmaceuticals, Cambridge, MA.
Background: Vedolizumab is a biologic drug approved by the US Food and Drug Administration (FDA) for the treatment of adults with moderately to severely active Crohn's disease (CD) or ulcerative colitis (UC) who have had inadequate response to, lost response to, or were intolerant of immunomodulators or tumor necrosis factor (TNF) blocker therapy, or who had an inadequate response with, were intolerant to, or demonstrated dependence on corticosteroid therapy. The biologics approved by the FDA for CD and/or UC include adalimumab, infliximab, golimumab, certolizumab, and ustekinumab.
Objective: To assess the budget impact of including vedolizumab in a health plan formulary among current options as a preferred first-line biologic therapy for UC and CD rather than only for patients who failed anti-TNF therapy. Read More
Rep Pract Oncol Radiother 2019 Jan-Feb;24(1):56-59. Epub 2018 Nov 12.
Radiation Oncology Department, Catalan Institute of Oncology, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Introduction: Uveal melanoma is a rare tumour caused by genetic factors and alterations in the immune response. Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disorder characterized by an inappropriate or excessive immune response. The two main types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). Read More
Gastroenterology 2018 Nov 16. Epub 2018 Nov 16.
First Department of Medicine, Universitaetsklinikum Erlangen, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, Germany. Electronic address:
Background & Aims: Intestinal fibrosis is a long-term complication in inflammatory bowel diseases (IBD) frequently resulting in functional damage, bowel obstruction, and surgery. Interleukin 36 (IL36) is a group of cytokines in the IL1 family with inflammatory effects. We studied expression of IL36 and its receptor, interleukin 1 receptor like 2 (IL1RL2 or IL36R) in development of intestinal fibrosis in human tissues and mice. Read More
Eur J Clin Invest 2018 Nov 19:e13054. Epub 2018 Nov 19.
Department of Laboratory Medicine, University of Pécs Medical School, 7624, Pécs, Ifjúság u. 13, Hungary.
Background: Laboratory markers are essential tools in the follow-up of patients with Crohn's disease (CD). Our aim was to investigate urinary concentrations of orosomucoid in relation to the inflammatory activity of CD and to compare it with clinical indices and conventional laboratory parameters.
Materials And Methods: Blood and urine samples of 86 patients (55 adults and 31 children) with CD and 68 healthy individuals (38 adults and 30 children) as controls were analyzed. Read More
Phytother Res 2018 Nov 18. Epub 2018 Nov 18.
Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, Athens, Greece.
There is a keen research upon the effects of nutraceuticals on inflammatory bowel disease. The purpose of this study was to explore the effect of mastiha supplement, rich in bioactive nutraceuticals, in active inflammatory bowel disease. This is a randomised, double-blind, placebo-controlled clinical trial. Read More
Surg Obes Relat Dis 2018 Oct 14;14(10):1544-1551. Epub 2018 Jun 14.
Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway; Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway.
Background: Knowledge of optimal diagnostic workup, etiology, and response to treatment of chronic abdominal pain after Roux-en-Y gastric bypass (RYGB) is limited.
Objective: To define the etiology of chronic abdominal pain presenting at the 5-year follow-up after RYGB and to evaluate response to treatment.
Setting: Oslo University Hospital (tertiary referral center for obesity surgery). Read More
Intest Res 2018 Nov 20. Epub 2018 Nov 20.
Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Background/aims: Incidences of inflammatory bowel diseases (IBDs), ulcerative colitis (UC), and Crohn's disease (CD), have been increasing in Asia. In this study, we report the relevant clinical characteristics and determined the epidemiological trend of IBD in Taiwan from 2001 to 2015.
Methods: A retrospective study was conducted to analyze data recorded from January 2001 through December 2015 in the registered database compiled by the National Health Insurance and provided by the Ministry of Health and Welfare, Taiwan. Read More
Clin Gastroenterol Hepatol 2018 Nov 15. Epub 2018 Nov 15.
Department of Medicine Huddinge, Unit of Gastroenterology and Rheumatology, Karolinska Institutet, Stockholm, Sweden; Division of Hepatology, Department of Upper GI Disease, Karolinska University Hospital, Stockholm, Sweden. Electronic address:
Background & Aims: There is increasing evidence that statins can benefit patients with chronic liver diseases, but their effects have not been studied in patients with primary sclerosing cholangitis (PSC). We performed a nationwide study in Sweden to determine the effects of exposure to drugs, including statins, in patients with PSC.
Methods: We studied a population-based cohort of patients in Sweden with PSC and concomitant ulcerative colitis or Crohn´s disease from 2005 through 2014 (n=2914), followed through 2016. Read More
Arch Pathol Lab Med 2018 Nov 16. Epub 2018 Nov 16.
From the Department of Pathology (Drs Setoodeh and Gopal) and the Division of Digestive and Liver Diseases (Drs Singal and Ahmed), UT Southwestern Medical Center, Dallas, Texas; the Department of Pathology, Mercy Medical Center, Baltimore, Maryland (Dr Liu); the Department of Pathology, University of Iowa Healthcare, Iowa City (Dr Boukhar); the Department of Pathology (Dr Westerhoff) and the Division of Gastroenterology and Hepatology (Dr Waljee), University of Michigan Health System, Ann Arbor; and VA Center for Clinical Management Research, VA Ann Arbor Health Care System, Ann Arbor, Michigan (Dr Waljee).
Context.—: Conflicting data about the clinical significance of microscopic Crohn disease (CD) activity at resection margins have led to varying practice patterns for routine reporting by pathologists.
Objective. Read More
Colorectal Dis 2018 Nov 16. Epub 2018 Nov 16.
Department of Colon & Rectal Surgery, Digestive Disease and Surgery Institute Cleveland Clinic, 9500 Euclid Avenue, A30, Cleveland, OH, 44195-0001.
Aim: Ileal pouch-anal anastomosis failure occurs in approximately 5 - 10% of patients. We aimed to compare short-term (30-day) post-operative outcomes associated with pouch revision and with pouch excision using a large international database. Our null hypothesis was that there is no statistically significant difference in overall post-operative complications between patients selected for pouch revision vs. Read More
Patient 2018 Nov 15. Epub 2018 Nov 15.
Medical Affairs Department, Merck Sharp and Dohme Spain, Madrid, Spain.
Background: Patient experience is acknowledged as a principal aspect of quality healthcare delivery, and it has implications with regard to outcomes.
Objectives: Our objective was to evaluate the healthcare experience of patients with chronic diseases to identify patient-perceived healthcare gaps and to assess the influence of demographic and healthcare-related variables on patient experiences.
Methods: A cross-sectional survey was delivered to adult patients with chronic diseases: diabetes mellitus (DM), human immunodeficiency virus (HIV) infection, inflammatory bowel disease (IBD) or rheumatic diseases. Read More
J Ultrason 2018 ;18(74):247-254
Medizinische Klinik 2, Caritas-Krankenhaus Bad Mergentheim, Bad Mergentheim, Germany.
We present a report on ultrasound findings in extragenital endometriosis and a literature review accompanied by illustrations. Intestinal endometriosis should be considered in female patients of reproductive age who present with constipation, gastrointestinal bleeding, nausea, vomiting, cramp-like abdominal pain, diarrhoea and pelvic pain. Although definitive preoperative diagnosis of endometriosis is difficult, clinical suspicion and appropriate imaging might prevent extensive surgical procedures with higher morbidity. Read More
Front Pediatr 2018 30;6:317. Epub 2018 Oct 30.
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Inflammatory bowel diseases (IBD), encompassing both Crohn Disease (CD) and ulcerative colitis (UC) are globally prevalent diseases, impacting children of all ages. The hallmark of IBD is a perturbed immune system that leads to continuous inflammation in the gut and challenges optimal treatment. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κβ), a nuclear transcription factor, plays a major role in gut homeostasis and contributes significantly toward a balanced, homeostatic immune system. Read More
JMIR Res Protoc 2018 Nov 12;7(11):e11317. Epub 2018 Nov 12.
IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada.
Background: There has been limited longitudinal research that has comprehensively evaluated possible factors in the exacerbation of inflammatory bowel disease (IBD) symptoms with or without associated inflammation. Evolving Web-based technologies facilitate frequent monitoring of patients' experiences and allow a fine-grained assessment of disease course.
Objective: We aimed to prospectively identify factors associated with symptom exacerbation and inflammation in IBD including psychological functioning, diet, health behaviors, and medication adherence. Read More
PLoS One 2018 13;13(11):e0206911. Epub 2018 Nov 13.
Department of Surgery, Division of General Surgery and Comprehensive Center for Perioperative Medicine, Medical University of Vienna, Vienna, Austria.
Purpose: Little is known about the perioperative dynamic of albumin and its effect on surgical outcome in Crohn's disease. Thus, we aimed to assess postoperative changes of albumin levels and their potentially predictive role for complications after laparoscopic intestinal resections.
Methods: We identified 182 patients who underwent laparoscopic intestinal resection for symptomatic Crohn´s disease between 2000 and 2014 for this retrospective cohort study. Read More
AJR Am J Roentgenol 2018 Nov 13:1-10. Epub 2018 Nov 13.
1 Department of Diagnostic Radiology, Medical Hospital, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Objective: The objectives of our study were to establish the efficacy of a 5-point MR enterocolonography classification for assessing Crohn disease (CD) activity, compare this classification with a validated MRI score (i.e., the MR index of activity [MaRIA]), and compare both with endoscopic findings, which were assessed using the Crohn disease endoscopic index of severity (CDEIS). Read More
JAMA Dermatol 2018 Oct 24. Epub 2018 Oct 24.
Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taiwan.
Importance: Patients with psoriasis may experience comorbidities involving cardiovascular diseases, chronic kidney disease, uveitis, psychiatric disturbances, and metabolic syndrome. However, the association between psoriasis and inflammatory bowel disease (IBD) has been largely unclear.
Objective: To investigate the association of psoriasis with IBD. Read More
Intest Res 2018 Nov 12. Epub 2018 Nov 12.
Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
The incidence of pediatric-onset inflammatory bowel disease (IBD) is on the rise, accounting for up to 25% of IBD cases. Pediatric IBD often has extensive bowel involvement with aggressive and rapidly progressing behavior compared to adult IBD. Because IBD has a high morbidity rate and can have a lifelong impact, successful transition from pediatric to adult care is important to maintain the continuity of care. Read More
JAMA Ophthalmol 2018 Nov 8. Epub 2018 Nov 8.
Department of Ophthalmology and Visual Science, Kellogg Eye Center, University of Michigan, Ann Arbor.
J Crohns Colitis 2018 Nov 12. Epub 2018 Nov 12.
Crohn & Colitis Centre Rijnstate, Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, the Netherlands.
Dig Liver Dis 2018 Oct 4. Epub 2018 Oct 4.
Chronic Inflammatory Bowel Disease Dept. Unit, Hospital "Villa Sofia - Cervello", Palermo, Italy.
The MARS-5 (Medication Adherence Report Scale) was developed in English. The aim of this project was to analyse the MARS-5I (© Prof Rob Horne) psychometric properties and to identify whether its Italian translation is suitable for assessing medication adherence in Crohn Disease (CD) Italian patients. The MARS was translated and linguistically validated in Italian. Read More
Chem Biol Interact 2018 Nov 5;298:57-65. Epub 2018 Nov 5.
Department of Histology, Faculty of Medicine, Tanta University, Egypt.
Objective: Inflammatory bowel diseases (IBD) are chronic and recurrent disorders of the gastrointestinal tract with unknown etiology and have two major forms, ulcerative colitis (UC) and Crohn diseases. In view of the adverse effects and incomplete efficacy of currently administered drugs, it is essential to investigate new and harmless drugs with more desirable beneficial effects. Statins have many additional pleiotropic effects other than their lipid-lowering effect. Read More
Front Immunol 2018 22;9:2307. Epub 2018 Oct 22.
Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study. Inhibition of retinoic acid-related orphan receptor gamma (RORγt), the master regulator of the Th17 signature, is currently being explored in inflammatory diseases. Our aim was to determine the effect of a novel oral RORγt antagonist (BI119) in human CD and on an experimental model of intestinal inflammation. Read More
J Immunol Res 2018 1;2018:7270486. Epub 2018 Oct 1.
Department of Public Health, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan.
Crohn's disease is one of the systemic autoimmune diseases. It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus. The most affected area by Crohn's disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed. Read More
BMC Gastroenterol 2018 Nov 6;18(1):164. Epub 2018 Nov 6.
Dipartimento di Medicina Interna e Specialità Mediche, Università "Sapienza", Policlinico "Umberto I", V.le del Policlinico, 155, 00161, Rome, Italy.
Background: Clinical severity and intestinal lesions of Crohn's disease (CD) usually progress over time and require a step up adjustment of the therapy either to prevent or to treat complications. The aim of the study was to develop a simple risk scoring system to assess in individual CD patients the risk of disease progression and the need for more intensive treatment and monitoring.
Methods: Prospective cohort study (January 2002-September 2014) including 160 CD patients (93 female, median age 31 years; disease behavior (B)1 25%, B2 55. Read More
Gut Liver 2018 Oct 18. Epub 2018 Oct 18.
Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Uchimaru 19-1, Morioka 020-8505, Japan.
Background/aims: We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene () as causative variants of chronic nonspecific multiple ulcers of the small intestine (CEAS). The aim of this study was to investigate the gastroduodenal expression of the SLCO2A1 protein in patients with CEAS and Crohn's disease (CD).
Methods: Immunohistochemical staining for SLCO2A1 was performed with a polyclonal antibody, HPA013742, on gastroduodenal tissues obtained by endoscopic biopsy from four patients with CEAS and 29 patients with CD. Read More
Dig Dis 2018 Nov 2:1-9. Epub 2018 Nov 2.
Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.
Background: The inflammatory bowel disease (IBD) is a chronic lifelong inflammation that may affect the entire gastro-intestinal tract in Crohn's disease and the colon in ulcerative colitis (UC). Diet plays an important role in IBD patients and many of them follow strict diet restriction in order to reduce complaints and prolong remission intervals. The aim of this study was to assess dietary beliefs, dietary behaviour and nutrition knowledge in Dutch adults with IBD to enable considering the patient's perspective on dietary advice. Read More