59,573 results match your criteria Crohn's Disease and NOD2 CARD15


Secretory Sorcery: Paneth Cell Control of Intestinal Repair and Homeostasis.

Cell Mol Gastroenterol Hepatol 2021 Jun 18. Epub 2021 Jun 18.

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC USA 27607. Electronic address:

Paneth cells are professional secretory cells that, classically, play a role in the innate immune system by secreting antimicrobial factors into the lumen to control enteric bacteria. In this role, Paneth cells are able to sense ques from luminal bacteria and respond by changing production of these factors to protect the epithelial barrier. Paneth cells rely on autophagy to regulate their secretory capability and capacity. Read More

View Article and Full-Text PDF

Deficits in geriatric assessment associate with disease activity and -burden in older patients with inflammatory bowel disease.

Clin Gastroenterol Hepatol 2021 Jun 18. Epub 2021 Jun 18.

Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, the Netherlands.

Background & Aims: We aimed to perform geriatric assessment in older inflammatory bowel disease (IBD) patients to evaluate which IBD characteristics associate with deficits in geriatric assessment and the impact of deficits on disease burden (health-related quality of life (HRQoL)).

Methods: A prospective multicenter cohort study including 405 consecutive outpatient IBD patients aged ≥65 years. Somatic domain (comorbidity, polypharmacy, malnutrition), impairments in (instrumental) activities of daily living, physical capacity (handgrip strength, gait speed), mental (depressive symptoms, cognitive impairment), and social domain (life-partner) were assessed. Read More

View Article and Full-Text PDF

Systematic review: efficacy of escalated maintenance anti-tumour necrosis factor therapy in Crohn's disease.

Aliment Pharmacol Ther 2021 Jun 21. Epub 2021 Jun 21.

Faculty of Medicine, Dentistry and Health Sciences, Melbourne Medical School, The University of Melbourne, Melbourne, Vic., Australia.

Background: Loss of response to anti-TNF agents is a common clinical problem. Dose escalation may be effective for reestablishing clinical response in Crohn's disease (CD).

Aims: To perform a systematic review assessing the efficacy of escalated maintenance anti-TNF therapy in CD. Read More

View Article and Full-Text PDF

Clinical Efficacy of Infliximab in Patients With Crohn Disease in Different Locations of Disease Pathology: A Meta-Analysis.

Clin Invest Med 2021 Jun 21;44(2):E27-35. Epub 2021 Jun 21.

School of Life Sciences, Nanjing University, Nanjing, China; School of Biopharmacy, China Pharmaceutical University, Nanjing, China; Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc., Changzhou, China.

Purpose: Infliximab (INX) has been approved for treating Crohn disease (CD) for many years, showing promis-ing efficacy in the clinic. However, the efficacy of the drug and the prognosis of CD vary significantly with dif-ferent locations of disease pathology. This study evaluated the efficacy of INX and prognosis in CD in different locations of disease pathology using systematic meta-analysis. Read More

View Article and Full-Text PDF

Association of autoimmune diseases with cardiomyopathy: a nationwide follow-up study from Sweden.

Eur Heart J Qual Care Clin Outcomes 2021 Jun 21. Epub 2021 Jun 21.

Center for Primary Health Care Research, Lund University, Sweden.

Background: Certain autoimmune diseases (AD), such as Crohn's disease and celiac diseases, have been linked to acute cardiovascular disorders. We examined whether there is an association between 43 different ADs and risk of subsequent hospitalization and mortality of cardiomyopathy in a nationwide follow-up study in Sweden.

Methods: All individuals in Sweden hospitalized with a main diagnosis of an AD (n = 955,410) without previous or coexisting cardiomyopathy, between January 1, 1987 and December 31 2018, were followed for hospitalization or mortality of cardiomyopathy. Read More

View Article and Full-Text PDF

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies.

J Vis Exp 2021 Jun 2(172). Epub 2021 Jun 2.

AbbVie, Cambridge Research Center;

The immune system functions to defend humans against foreign invaders such as bacteria and viruses. However, disorders of the immune system may lead to autoimmunity, inflammatory disease, and cancer. The inflammatory bowel diseases (IBD)-Crohn's disease (CD) and ulcerative colitis (UC)-are chronic diseases marked by relapsing intestinal inflammation. Read More

View Article and Full-Text PDF

In vitro Monitoring of Extracellular pH in Real-Time.

J Vis Exp 2021 Jun 3(172). Epub 2021 Jun 3.

Mucosal Inflammation Program, University of Colorado Anschutz Medical Campus; Department of Medicine, University of Colorado Anschutz Medical Campus; Rocky Mountain Regional Veterans Affairs Medical Center;

Early accumulation of neutrophils (PMN) is a hallmark of acute intestinal inflammation. This acute inflammation is either resolved or progresses to chronic inflammation. Without efficient PMN clearance at sites of infiltration, PMN can accumulate and contribute to chronic inflammatory conditions, including the intestinal diseases ulcerative colitis (UC) and Crohn's Disease (CD). Read More

View Article and Full-Text PDF

Development and Validation of a Pediatric MRI-Based Perianal Crohn Disease (PEMPAC) Index-A Report from the ImageKids Study.

Inflamm Bowel Dis 2021 Jun 21. Epub 2021 Jun 21.

Radiology Department, Shaare Zedek Medical Center, Jerusalem, Israel.

Background: As part of the prospective multicenter ImageKids study, we aimed to develop and validate the pediatric MRI-based perianal Crohn disease (PEMPAC) index.

Methods: Children with Crohn disease with any clinical perianal findings underwent pelvic magnetic resonance imaging at 21 sites globally. The site radiologist and 2 central radiologists provided a radiologist global assessment (RGA) on a 100 mm visual analog scale and scored the items selected by a Delphi group of 35 international radiologists and a review of the literature. Read More

View Article and Full-Text PDF

Limited long-term treatment persistence of first anti-TNF therapy in 538 patients with inflammatory bowel diseases: a 20-year real-world study.

Aliment Pharmacol Ther 2021 Jun 20. Epub 2021 Jun 20.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria.

Background: Anti-TNF antibodies were the first biologic treatment option for patients with inflammatory bowel diseases.

Aims: To assess length of treatment persistence of first anti-TNF therapy and influencing factors used in the standard care of patients with inflammatory bowel diseases.

Methods: Single-centre, retrospective study from a register including patients who received anti-TNF therapy in the last 20 years at the study centre. Read More

View Article and Full-Text PDF

Superior treatment persistence with ustekinumab in Crohn's disease and vedolizumab in ulcerative colitis compared with anti-TNF biological agents: real-world registry data from the Persistence Australian National IBD Cohort (PANIC) study.

Aliment Pharmacol Ther 2021 Jun 20. Epub 2021 Jun 20.

Gastroenterology and Liver Services, Concord Repatriation General Hospital, Sydney, NSW, Australia.

Background: Medication persistence contributes real-world evidence about treatment effectiveness, tolerability and prescriber and patient acceptability.

Aims: To evaluate persistence of biological agents in Crohn's disease (CD) and ulcerative colitis (UC) and the effects of immunomodulator use and treatment lines.

Methods: Retrospective national population-based data on treatment persistence for adalimumab, infliximab vedolizumab and ustekinumab for CD and UC were analysed from the Australian Pharmaceutical Benefits Scheme using Kaplan-Meier analysis and Cox proportional hazards models. Read More

View Article and Full-Text PDF

Ultrasound-Guided Percutaneous Drainage of Abdominal Abscess in a Patient With Crohn's Disease: A Case Report.

Front Surg 2021 4;8:616586. Epub 2021 Jun 4.

International School "Medicine of the Future", I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

The autoimmune process in Crohn's disease exacerbates destructive changes in the intestinal wall and leads to complications such as bleeding (21. 9%), strictures (21.6%), and abscesses (19. Read More

View Article and Full-Text PDF

Risk of Inflammatory Bowel Disease Following Appendectomy in Adulthood.

Front Med (Lausanne) 2021 2;8:661752. Epub 2021 Jun 2.

Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.

The appendix has a complicated immune function, and appendectomy may derange the immune system. Studies on the relationship between appendectomy and subsequent inflammatory bowel disease (IBD) have been inconsistent. We conducted a nationwide cohort study consisting of individuals who underwent appendectomy to evaluate the incidence and risk of ulcerative colitis (UC) and Crohn's disease (CD). Read More

View Article and Full-Text PDF

Glucocorticoid Therapy in Inflammatory Bowel Disease: Mechanisms and Clinical Practice.

Front Immunol 2021 3;12:691480. Epub 2021 Jun 3.

Section of Pharmacology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn's disease (CD). IBD etiopathology is multifactorial and involves alteration of immune cells and chronic activation of the inflammatory cascade against yet unknown environmental factors that trigger the disease. IBD therapy aims at improving the quality of life and reducing the risk of disease-related complications to avoid the need for surgery. Read More

View Article and Full-Text PDF

Changes in the Long-term Prognosis of Crohn's Disease between 1986 and 2015: The Population-Based Songpa-Kangdong Inflammatory Bowel Disease Cohort Study.

Gut Liver 2021 Jun 22. Epub 2021 Jun 22.

Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background/aims: The long-term course of Crohn's disease (CD) has never been evaluated in non-Caucasian population-based cohorts. The aim of the present study was to evaluate the longterm prognosis of Korean CD patients in the well-defined population-based Songpa-Kangdong inflammatory bowel disease cohort.

Methods: Outcomes of disease and their predictors were evaluated for 418 patients diagnosed with CD between 1986 and 2015. Read More

View Article and Full-Text PDF

Immunization in patients with inflammatory bowel disease: Still far from standards.

Dig Liver Dis 2021 Jun 17. Epub 2021 Jun 17.

Inflammatory Bowel Disease Program, Gastroenterology Section, Internal Medicine Department, Clínica Universidad de los Andes, Chile.

View Article and Full-Text PDF

Antibiotics in pediatric Inflammatory Bowel Diseases: a systematic review.

Expert Rev Gastroenterol Hepatol 2021 Jun 21. Epub 2021 Jun 21.

Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.

Introduction: : Current available therapies in pediatric Inflammatory Bowel Disease (IBD) target the immune system and often fail to sustain long term remission. Therefore, there is a high need for development of alternative treatment strategies such as antibiotics in pediatric IBD.

Areas Covered: : This study systematically assessed efficacy and safety of antibiotics in pediatric IBD. Read More

View Article and Full-Text PDF

Gp130 signaling in NOD2-driven Crohn's disease: a key player in fibrosis and a novel target for refractory patients.

Gastroenterology 2021 Jun 16. Epub 2021 Jun 16.

Institute of Biomedicine of Seville (IBiS), Spanish National Research Council (CSIC), University of Seville, Virgen del Rocio University Hospital, Seville, Spain.

View Article and Full-Text PDF

Developing an Online Program for Self-Management of Fatigue, Pain, and Urgency in Inflammatory Bowel Disease: Patients' Needs and Wants.

Dig Dis Sci 2021 Jun 19. Epub 2021 Jun 19.

Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.

Background: Inflammatory bowel disease (IBD) is a lifelong relapsing-remitting condition, characterized by troublesome symptoms including fatigue, pain, and bowel urgency. These symptoms can persist even in clinical remission and have a debilitating impact on social, work-related and intimate domains of life. Symptom self-management can be challenging for some patients, who could potentially benefit from an online self-management tool. Read More

View Article and Full-Text PDF

[Economic burden and factors associated with Crohn's disease].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Jun;53(3):555-559

Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China.

Objective: To study the economic burden of Crohn's disease and its related factors, and to provide opinions for reducing personal burden and improving reimbursement policy.

Methods: Using a cross-sectional method, a self-created questionnaire based on the basic principles of health services research was used to survey Crohn's disease patients served by the Shanghai volunteer service foundation platform. Information collected included basic characteristics, therapy, and medical costs related to Crohn's disease in the past 12 months. Read More

View Article and Full-Text PDF

Absent XIAP expression in T cell blasts and causal XIAP mutations including non-coding deletion.

Pediatr Int 2021 Jun 18. Epub 2021 Jun 18.

Department of Pediatrics, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Background: X-linked inhibitor of apoptosis protein (XIAP) deficiency is one of inborn errors of immunity characterized by recurrent hemophagocytic lymphohistiocytosis (HLH) and refractory inflammatory bowel disease (IBD) mimicking Crohn's disease (CD). The aim of this study is to make accurate diagnosis of XIAP deficiency based on genetic and XIAP expression studies and to investigate endoscopic findings shared by patients with this disease.

Methods: Four male patients with recurrent HLH and long-term refractory IBD were studied for the diagnosis of XIAP deficiency. Read More

View Article and Full-Text PDF

Bone mineral density in spanish children at the diagnosis of inflammatory bowel disease.

Arch Osteoporos 2021 Jun 19;16(1):96. Epub 2021 Jun 19.

Pediatric Gastroenterology and Hepatology Unit, University Hospital La Fe, Avda. Fernando Abril Martorell 106, 46026, Valencia, Spain.

The association between low bone mineral density (BMD) and inflammatory bowel disease (IBD) is already known. Our study, performed in Spanish pediatric IBD patients at diagnosis onset, shows that low BMD already existed at the beginning of the disease. Low weight and height are also associated with low BMD and have to be considered as risk factors. Read More

View Article and Full-Text PDF

Human intelectin-1 (ITLN1) genetic variation and intestinal expression.

Sci Rep 2021 Jun 18;11(1):12889. Epub 2021 Jun 18.

Department of Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA, 95616, USA.

Intelectins are ancient carbohydrate binding proteins, spanning chordate evolution and implicated in multiple human diseases. Previous GWAS have linked SNPs in ITLN1 (also known as omentin) with susceptibility to Crohn's disease (CD); however, analysis of possible functional significance of SNPs at this locus is lacking. Using the Ensembl database, pairwise linkage disequilibrium (LD) analyses indicated that several disease-associated SNPs at the ITLN1 locus, including SNPs in CD244 and Ly9, were in LD. Read More

View Article and Full-Text PDF

Calprotectin: from biomarker to biological function.

Gut 2021 Jun 18. Epub 2021 Jun 18.

Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria

The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary habits worldwide. Crohn's disease and ulcerative colitis are chronic debilitating conditions that afflict individuals with substantial morbidity and challenge healthcare systems across the globe. Since identification and characterisation of calprotectin (CP) in the 1980s, faecal CP emerged as significantly validated, non-invasive biomarker that allows evaluation of gut inflammation. Read More

View Article and Full-Text PDF

Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis.

Free Radic Biol Med 2021 Jun 15. Epub 2021 Jun 15.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital, School of Medicine, Zhejiang University, Lishui, 323000, China; Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. Electronic address:

Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic recurrent and incurable gastrointestinal diseases with an unknown etiology that leads to a high risk of developing colitis-associated colorectal cancer (CRC).

Objectives: In this study, we measured the expression characteristics of MELK in IBD and CRC tissues and explored the regulatory effect of OTSSP167 (a MELK-selective inhibitor) on the mice models of colitis and colitis-associated carcinogenesis and analyzed the specific molecular mechanisms.

Methods: DSS-induced colitis and colitis-associated carcinogenesis (CAC) model were treated with MELK inhibitor OTSSP167 then the fight against effect of OTSSP167 in the clinical symptoms of colitis and CAC was measured. Read More

View Article and Full-Text PDF

Risk factors for upper and lower type prolonged postoperative ileus following surgery for Crohn's disease.

Int J Colorectal Dis 2021 Jun 17. Epub 2021 Jun 17.

Department of General and Visceral Surgery, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität Zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.

Purpose: Prolonged postoperative ileus (PPOI) is common after bowel resections, especially in Crohn's disease (CD). The pathophysiology of PPOI is not fully understood. PPOI could affect only the upper or lower gastrointestinal (GI) tract. Read More

View Article and Full-Text PDF

Incidence and Outcomes of Home Parenteral Nutrition in Patients With Crohn Disease in Olmsted County, Minnesota.

Crohns Colitis 360 2020 Oct 21;2(4):otaa083. Epub 2020 Oct 21.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Background: We sought to estimate the incidence of home parenteral nutrition (HPN) use in a population-based cohort of patients with Crohn disease (CD), and to assess clinical outcomes and complications associated with HPN.

Methods: We used the Rochester Epidemiology Project (REP) to identify residents of Olmsted County, who were diagnosed with CD between 1970 and 2011, and required HPN.

Results: Fourteen out of 429 patients (3. Read More

View Article and Full-Text PDF
October 2020

Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management: A case report.

World J Clin Cases 2021 Jun;9(16):4081-4089

Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Background: Glycogen storage disease (GSD) is an autosomal recessive inborn metabolic disorder. Patients with GSD are prone to hypoglycaemia, hyperlactacidemia and bleeding. GSD type 1b (GSD-1b) patients specifically can develop neutropenia, recurrent bacterial infection and inflammatory bowel disease (IBD). Read More

View Article and Full-Text PDF

Management and outcomes of surgical patients with intestinal Behçet's disease and Crohn's disease in southwest China.

World J Clin Cases 2021 Jun;9(16):3858-3868

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Gastrointestinal involvement in Behçet's disease (GIBD) and Crohn's disease (CD) are inflammatory diseases sharing a considerable number of similarities. However, different from CD, the operative and postoperative management of GIBD remains largely empirical because of the lack of comprehensive treatment guidelines.

Aim: To compare surgical patients with GIBD and those with CD in a medical center and identify notable clinical features and effective postoperative treatment for surgical patients with GIBD. Read More

View Article and Full-Text PDF