262 results match your criteria Critical care research and practice[Journal]


Emerging Evidence concerning the Role of Sirtuins in Sepsis.

Crit Care Res Pract 2018 8;2018:5489571. Epub 2018 Nov 8.

Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou 510515, Guangdong, China.

Sepsis, a dysregulated host response to infection, is a major public health concern. Though experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis is not completely understood. To date, numerous studies have shown that sirtuins (silent mating type information regulation 2 homolog), which belong to the class III histone deacetylases, may have a varied, or even opposite, effect in the pathogenesis of sepsis. Read More

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http://dx.doi.org/10.1155/2018/5489571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250024PMC
November 2018

Gait Speed Is Not Associated with Vasogenic Shock or Cardiogenic Shock following Cardiac Surgery, but Is Associated with Increased Hospital Length of Stay.

Crit Care Res Pract 2018 23;2018:1538587. Epub 2018 Oct 23.

Associate Professor, Department of Anesthesiology, University of Kansas Medical Center, Kansas, KS, USA.

Objective: Frailty has been associated with adverse outcomes following cardiac surgery. Gait speed has been validated as a marker of frailty. Slow gait speed has been found to be associated with mortality after cardiac surgery. Read More

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http://dx.doi.org/10.1155/2018/1538587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218793PMC
October 2018
1 Read

Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using Extrasystoles.

Crit Care Res Pract 2018 1;2018:5697092. Epub 2018 Oct 1.

Research Centre for Emergency Medicine, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Background: Extrasystoles may be useful for predicting the response to fluid therapy in hemodynamically unstable patients but their prevalence is unknown. The aim of this study was to estimate the availability of extrasystoles in intensive care unit patients diagnosed with sepsis. The study aim was not to validate the fluid responsiveness prediction ability of extrasystoles. Read More

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https://www.hindawi.com/journals/ccrp/2018/5697092/
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http://dx.doi.org/10.1155/2018/5697092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188589PMC
October 2018
6 Reads

Creatinine- and Cystatin C-Based Incidence of Chronic Kidney Disease and Acute Kidney Disease in AKI Survivors.

Crit Care Res Pract 2018 27;2018:7698090. Epub 2018 Sep 27.

Section of Anaesthesia and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

Background: Renal dysfunction after acute kidney injury (AKI) is common, potentially modifiable, but poorly understood. Acute kidney disease (AKD) describes renal dysfunction 7 to 90 days after AKI and is determined by percentage change in creatinine from baseline. Chronic kidney disease (CKD) is defined as the estimated glomerular filtration rate (eGFR) less than 60 ml/min/1. Read More

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https://www.hindawi.com/journals/ccrp/2018/7698090/
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http://dx.doi.org/10.1155/2018/7698090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180984PMC
September 2018
2 Reads

Institutional Incidence of Severe tPA-Induced Angioedema in Ischemic Cerebral Vascular Accidents.

Crit Care Res Pract 2018 27;2018:9360918. Epub 2018 Sep 27.

Beaumont Health-Royal Oak, 3601 W. 13 Mile Rd., Royal Oak, MI 48073, USA.

Introduction: Tissue plasminogen activator (tPA) is commonly used in ischemic cerebral vascular accidents (CVAs). tPA is generally well tolerated; however, orolingual angioedema is a well-documented adverse effect. Angioedema is generally mild, transient, and unilateral but can manifest as severe, life-threatening upper airway obstruction requiring intubation. Read More

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https://www.hindawi.com/journals/ccrp/2018/9360918/
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http://dx.doi.org/10.1155/2018/9360918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180929PMC
September 2018
10 Reads

Outcome in Patients with Isolated Moderate to Severe Traumatic Brain Injury.

Crit Care Res Pract 2018 23;2018:3769418. Epub 2018 Sep 23.

Department of Trauma, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3585 GA Utrecht, Netherlands.

Introduction: Traumatic brain injury (TBI) remains a major cause of death. Withdrawal of life-sustaining treatment (WLST) can be initiated if there is little anticipated chance of recovery to an acceptable quality of life. The aim of this study was firstly to investigate WLST rates in patients with moderate to severe isolated TBI and secondly to assess outcome data in the survivor group. Read More

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https://www.hindawi.com/journals/ccrp/2018/3769418/
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http://dx.doi.org/10.1155/2018/3769418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174733PMC
September 2018
8 Reads

Characteristics, Outcomes, and Cost Patterns of High-Cost Patients in the Intensive Care Unit.

Crit Care Res Pract 2018 2;2018:5452683. Epub 2018 Sep 2.

Division of Critical Care Medicine, University of Ottawa, Ottawa, ON, Canada.

Background: ICU care is costly, and there is a large variation in cost among patients.

Methods: This is an observational study conducted at two ICUs in an academic centre. We compared the demographics, clinical data, and outcomes of the highest decile of patients by total costs, to the rest of the population. Read More

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http://dx.doi.org/10.1155/2018/5452683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139208PMC
September 2018
1 Read

Emergency Laparotomy in the Critically Ill: Futility at the Bedside.

Crit Care Res Pract 2018 26;2018:6398917. Epub 2018 Aug 26.

Division of Traumatology, Surgical Critical Care & Emergency Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Background: Critically ill patients are often evaluated for an intra-abdominal catastrophe. In the absence of a preoperative diagnosis, abdominal exploration may be offered despite desperate circumstances. We hypothesize that (1) abdominal exploration for such patients is associated with a high mortality and (2) commonly obtained physiologic measures at laparotomy anticipate mortality. Read More

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https://www.hindawi.com/journals/ccrp/2018/6398917/
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http://dx.doi.org/10.1155/2018/6398917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129366PMC
August 2018
8 Reads

Buprenorphine versus Morphine in Paediatric Acute Pain: A Systematic Review and Meta-Analysis.

Crit Care Res Pract 2018 7;2018:3792043. Epub 2018 Aug 7.

Department of Anaesthesia and Pain Medicine, Sunshine Coast University Hospital, Birtinya, QLD, Australia.

Introduction: In lab-based studies, buprenorphine appears to have a ceiling effect on respiratory depression but not on analgesia. There is increasing evidence in adult patients that buprenorphine has no ceiling effect on analgesia or side effects. The aim of this study was to investigate the efficacy and adverse effects of buprenorphine versus morphine in paediatric acute pain. Read More

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http://dx.doi.org/10.1155/2018/3792043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109565PMC
August 2018
9 Reads

Updates in Neurocritical Care.

Crit Care Res Pract 2018 1;2018:1617359. Epub 2018 Aug 1.

Department of Critical Care, Keck Medical School, USC, Los Angeles, CA, USA.

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http://dx.doi.org/10.1155/2018/1617359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093028PMC
August 2018
1 Read

Predictors of Major Depressive Disorder following Intensive Care of Chronically Critically Ill Patients.

Crit Care Res Pract 2018 1;2018:1586736. Epub 2018 Aug 1.

Department of Psychotherapy and Psychosomatic Medicine, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Objective: Major depressive disorder (MDD) is a common condition following treatment in the Intensive Care Unit (ICU). Long-term data on MDD in chronically critically ill (CCI) patients are scarce. Hence, the primary aim of the present study was to investigate the frequency and predictors of MDD after intensive care of CCI patients. Read More

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http://dx.doi.org/10.1155/2018/1586736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093074PMC

A Proposal for an Intermediate Care Unit-Quality Measurement Framework.

Crit Care Res Pract 2018 29;2018:4560718. Epub 2018 Jul 29.

Division of Surgery, University Medical Centre Utrecht, Utrecht, Netherlands.

, , . The Intermediate Care Unit (IMCU) is a hospital unit which is logistically situated between the hospital ward and the Intensive Care Unit (ICU). There is debate regarding the value of the IMCU. Read More

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http://dx.doi.org/10.1155/2018/4560718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087599PMC
July 2018
6 Reads

Effects of Neuromuscular Electrical Stimulation of the Quadriceps and Diaphragm in Critically Ill Patients: A Pilot Study.

Crit Care Res Pract 2018 8;2018:4298583. Epub 2018 Jul 8.

Intensive Care Unit, Western Parana State University Hospital, Avenida Tancredo Neves 3224, Santo Onofre, 85806-470 Cascavel, PR, Brazil.

Background: Deep and respiratory muscle disorders are commonly observed in critically ill patients. Neuromuscular electrical stimulation (NMES) is an alternative to mobilize and to exercise that does not require active patient participation and can be used on bedridden patients.

Objective: Evaluate the effectiveness of the NMES therapy in quadriceps versus diaphragm subjects in mechanical ventilation (MV). Read More

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https://www.hindawi.com/journals/ccrp/2018/4298583/
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http://dx.doi.org/10.1155/2018/4298583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079614PMC
July 2018
17 Reads

Improved Outcomes following the Establishment of a Neurocritical Care Unit in Saudi Arabia.

Crit Care Res Pract 2018 18;2018:2764907. Epub 2018 Jul 18.

Neurocritical Care Unit, Critical Care Department, King Saud Medical City, Riyadh, Saudi Arabia.

Background: Dedicated neurocritical care units have dramatically improved the management and outcome following brain injury worldwide.

Aim: This is the first study in the Middle East to evaluate the clinical impact of a neurocritical care unit (NCCU) launched within the diverse clinical setting of a polyvalent intensive care unit (ICU).

Design And Methods: A retrospective before and after cohort study comparing the outcomes of neurologically injured patients. Read More

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http://dx.doi.org/10.1155/2018/2764907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079555PMC
July 2018
8 Reads

Reversal Strategies for Intracranial Hemorrhage Related to Direct Oral Anticoagulant Medications.

Crit Care Res Pract 2018 4;2018:4907164. Epub 2018 Jul 4.

Department of Anesthesiology, Anesthesiology Critical Care Medicine, Surgical and Trauma Intensive Care Unit, Galveston, TX 77555, USA.

Direct oral anticoagulants (DOACs) are a new class of anticoagulants that directly inhibit either thrombin or factor Xa in the coagulation cascade. They are being increasingly used instead of warfarin or other vitamin K antagonists (VKAs). Adverse side effects of DOACs may result in hemorrhagic complications, including life-threatening intracranial hemorrhage (ICH), though to a much lesser degree than VKAs. Read More

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http://dx.doi.org/10.1155/2018/4907164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057345PMC
July 2018
1 Read

Update in the Early Management and Reperfusion Strategies of Patients with Acute Ischemic Stroke.

Crit Care Res Pract 2018 28;2018:9168731. Epub 2018 Jun 28.

Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Acute ischemic stroke (AIS) remains a leading cause of death and long-term disability. The paradigms on prehospital care, reperfusion therapies, and postreperfusion management of patients with AIS continue to evolve. After the publication of pivotal clinical trials, endovascular thrombectomy has become part of the standard of care in selected cases of AIS since 2015. Read More

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http://dx.doi.org/10.1155/2018/9168731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046146PMC

Combination of APACHE Scoring Systems with Adductor Pollicis Muscle Thickness for the Prediction of Mortality in Patients Who Spend More Than One Day in the Intensive Care Unit.

Crit Care Res Pract 2018 3;2018:5490346. Epub 2018 Jun 3.

Department of Clinical Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The objective of the present study was to compare the ability of Acute Physiology and Chronic Health Evaluation (APACHE) scoring systems with the combination of an anthropometric variable score "adductor pollicis muscle (APM) thickness" to the APACHE systems in predicting mortality in the intensive care unit.

Methods: A prospective observational study was conducted with the APM thickness in the dominant hand, and APACHE II and III scores were measured for each patient upon admission. Given scores for the APM thickness were added to APACHE score systems to make two composite scores of APACHE II-APM and APACHE III-APM. Read More

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http://dx.doi.org/10.1155/2018/5490346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008737PMC
June 2018
5 Reads

Exploring Factors Affecting the Emergency Specialists' Decision-Making in Case of Emergencies in Patients.

Crit Care Res Pract 2018 17;2018:9579807. Epub 2018 May 17.

Department of Emergency Medicine, Kowsar Educational and Research Center, Semnan University of Medical Sciences, Semnan, Iran.

Introduction: Appropriate decision-making is essential in emergency situations; however, little information is available on how emergency decision-makers decide on the emergency status of the patients shifted to the emergency department of the hospital. This study aimed at explaining the factors that influence the emergency specialists' decision-making in case of emergency conditions in patients.

Methods: This study was carried out with a qualitative content analysis approach. Read More

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http://dx.doi.org/10.1155/2018/9579807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985091PMC
May 2018
2 Reads

Updates in Refractory Status Epilepticus.

Crit Care Res Pract 2018 8;2018:9768949. Epub 2018 May 8.

Department of Neurology, Detroit Medical Center and Wayne State University, Detroit, MI 48201, USA.

Refractory status epilepticus is defined as persistent seizures despite appropriate use of two intravenous medications, one of which is a benzodiazepine. It can be seen in up to 40% of cases of status epilepticus with an acute symptomatic etiology as the most likely cause. New-onset refractory status epilepticus (NORSE) is a recently coined term for refractory status epilepticus where no apparent cause is found after initial testing. Read More

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http://dx.doi.org/10.1155/2018/9768949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964484PMC
May 2018
2 Reads

Design and Deployment of a Pediatric Cardiac Arrest Surveillance System.

Crit Care Res Pract 2018 9;2018:9187962. Epub 2018 May 9.

Division of Health Sciences Informatics, Department of Anesthesiology and Critical Care Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.

Objective: We aimed to increase detection of pediatric cardiopulmonary resuscitation (CPR) events and collection of physiologic and performance data for use in quality improvement (QI) efforts.

Materials And Methods: We developed a workflow-driven surveillance system that leveraged organizational information technology systems to trigger CPR detection and analysis processes. We characterized detection by notification source, type, location, and year, and compared it to previous methods of detection. Read More

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http://dx.doi.org/10.1155/2018/9187962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966697PMC
May 2018
2 Reads

Child Psychiatry Engagement in the Management of Delirium in Critically Ill Children.

Crit Care Res Pract 2018 26;2018:9135618. Epub 2018 Apr 26.

Department of Anesthesiology and Critical Care Medicine, Charlotte R. Bloomberg Children's Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objectives: To characterize the engagement of child psychiatry by pediatric intensivists in cases of suspected delirium in a pediatric intensive care unit (PICU) prior to implementation of a delirium management algorithm with regards to recommendations, antipsychotic prescribing, and follow-up after PICU discharge.

Design: Retrospective chart review.

Setting: Single-center tertiary PICU. Read More

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http://dx.doi.org/10.1155/2018/9135618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944292PMC
April 2018
2 Reads

Clinical Utility of a Structured Program to Reduce the Risk of Health-Related Quality of Life Impairment after Discharge from Intensive Care Unit: A Real-World Experience.

Crit Care Res Pract 2018 8;2018:3838962. Epub 2018 May 8.

Department of Intensive Care, S. Maria Annunziata Hospital, Florence, Italy.

Background: Postdischarge deterioration in health-related quality of life (HRQoL) is a major clinical issue for patients after an intensive care unit (ICU) hospitalization. A significant proportion of these patients is known to develop a progressive worsening of mental and physical performance-the so-called post-intensive care syndrome (PICS).

Aim: We aimed at exploring the effects of a structured program for the management of ICU patients, aimed at improving postdischarge HRQoL and reducing the risk of PICS. Read More

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http://dx.doi.org/10.1155/2018/3838962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964427PMC
May 2018
4 Reads

New Optic Nerve Sonography Quality Criteria in the Diagnostic Evaluation of Traumatic Brain Injury.

Crit Care Res Pract 2018 30;2018:3589762. Epub 2018 Apr 30.

Neurocritical Care Unit, Critical Care Department, King Saud Medical City, Riyadh, Saudi Arabia.

Background: New sonographic quality criteria to optimize optic nerve sheath diameter (ONSD) measurements were suggested. The latter were correlated to elevated intracranial pressure (ICP) in traumatic brain injury (TBI).

Aim: We investigated whether ONSD measurements were correlated to simultaneous ICP measurements in severe TBI. Read More

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https://www.hindawi.com/journals/ccrp/2018/3589762/
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http://dx.doi.org/10.1155/2018/3589762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952494PMC
April 2018
5 Reads

Can Diaphragm Dysfunction Be Reliably Evaluated with Pocket-Sized Ultrasound Devices in Intensive Care Unit?

Crit Care Res Pract 2018 1;2018:5192647. Epub 2018 Apr 1.

Department of Pulmonary Critical Care Medicine, Gazi University School of Medicine, Ankara, Turkey.

Background: Diaphragm dysfunction (DD) is frequently seen in critically ill patients, and ultrasound could be a useful tool to detect it and to predict extubation success or failure in mechanically ventilated patients. Besides, it would also be useful in differential diagnosis of dyspnea and respiratory failure. The aim of this study is to evaluate usefulness and accuracy of pocket-sized ultrasound devices (PSDs) in assessment of DD in intensive care unit (ICU) patients in comparison with standard ultrasound devices (SD). Read More

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http://dx.doi.org/10.1155/2018/5192647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902116PMC
April 2018
2 Reads

Cerebral Pathophysiology in Extracorporeal Membrane Oxygenation: Pitfalls in Daily Clinical Management.

Crit Care Res Pract 2018 18;2018:3237810. Epub 2018 Mar 18.

Division of Neurocritical Care and Vascular Neurology, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

Extracorporeal membrane oxygenation (ECMO) is a life-saving technique that is widely being used in centers throughout the world. However, there is a paucity of literature surrounding the mechanisms affecting cerebral physiology while on ECMO. Studies have shown alterations in cerebral blood flow characteristics and subsequently autoregulation. Read More

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https://www.hindawi.com/journals/ccrp/2018/3237810/
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http://dx.doi.org/10.1155/2018/3237810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878897PMC
March 2018
3 Reads

Intensive Care Unit Rotations and Predictors of Career Choice in Pulmonary/Critical Care Medicine: A Survey of Internal Medicine Residency Directors.

Crit Care Res Pract 2018 6;2018:9496241. Epub 2018 Mar 6.

Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Massachusetts General Hospital, Boston, MA, USA.

Background: The United States (US) is experiencing a growing shortage of critical care medicine (CCM) trained physicians. Little is known about the exposures to CCM experienced by internal medicine (IM) residents or factors that may influence their decision to pursue a career in pulmonary/critical care medicine (PCCM).

Methods: We conducted a survey of US IM residency program directors (PDs) and then used multivariable logistic regression to identify factors that were predictive of residency programs with a higher percentage of graduates pursuing careers in PCCM. Read More

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http://dx.doi.org/10.1155/2018/9496241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859790PMC
March 2018
2 Reads

Efficacy of Dexmedetomidine versus Ketofol for Sedation of Postoperative Mechanically Ventilated Patients with Obstructive Sleep Apnea.

Crit Care Res Pract 2018 28;2018:1015054. Epub 2018 Jan 28.

Anesthesia and Surgical ICU Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.

Patients with sleep apnea are prone to postoperative respiratory complications, requiring restriction of sedatives during perioperative care. We performed a prospective randomized study on 24 patients with obstructive sleep apnea (OSA) who underwent elective surgery under general anesthesia. The patients were equally divided into two groups: : received dexmedetomidine loading dose 1 mcg/kg IV over 10 min followed by infusion of 0. Read More

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http://dx.doi.org/10.1155/2018/1015054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829338PMC
January 2018
3 Reads

Survey of Extent of Translation of Oral Healthcare Guidelines for ICU Patients into Clinical Practice by Nursing Staff.

Crit Care Res Pract 2017 18;2017:1348372. Epub 2017 Oct 18.

Department of Prosthodontics, Faculty of Dental Sciences, King George's Medical University, Lucknow, India.

Nosocomial infections in critically ill/ventilated patients result from bacterial load in oropharyngeal regions. Oral decontamination serves as the easiest effective means of controlling infections. Knowledge, attitude, and practices followed by healthcare personnel in intensive care settings need to be assessed to implement concrete measures in health-care. Read More

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http://dx.doi.org/10.1155/2017/1348372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664266PMC
October 2017
13 Reads

Challenges with Surveillance of Healthcare-Associated Infections in Intensive Care Units in South Africa.

Crit Care Res Pract 2017 12;2017:7296317. Epub 2017 Oct 12.

School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Background: The incidence of healthcare-associated infections (HAIs) in the public health sector in South Africa is not known due to the lack of a surveillance system. We report on the challenges experienced in the implementation of a surveillance system for HAIs in intensive care units (ICUs).

Methods: A passive, paper-based surveillance system was piloted in eight ICUs to measure the incidence of ventilator-associated pneumonia, catheter-associated urinary tract infection, and central line-associated bloodstream infection. Read More

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http://dx.doi.org/10.1155/2017/7296317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660820PMC
October 2017
7 Reads

Improvement in Quality Metrics Outcomes and Patient and Family Satisfaction in a Neurosciences Intensive Care Unit after Creation of a Dedicated Neurocritical Care Team.

Crit Care Res Pract 2017 8;2017:6394105. Epub 2017 Oct 8.

Department of Neurology, University of Missouri, 5 Hospital Drive, CE 540, Columbia, MO 65211, USA.

Introduction: Dedicated neurointensivists have been shown to improve outcome measurements in the neurosciences intensive care unit (NSICU). Quality outcome data in relation to patient and family satisfaction is lacking. This study evaluated the impact of newly appointed neurointensivists and creation of a neurocritical care team on quality outcome measures including patient satisfaction in a NSICU. Read More

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http://dx.doi.org/10.1155/2017/6394105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651093PMC
October 2017
18 Reads

A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU Depression.

Crit Care Res Pract 2017 13;2017:5804860. Epub 2017 Sep 13.

Department of Anesthesiology, University of Kansas Hospital, Kansas City, KS, USA.

Post-ICU Syndromes (PICS) remain a devastating problem for intensive care unit (ICU) survivors. It is currently unknown if de novo initiation of an antidepressant medication during ICU stay decreases the prevalence of post-ICU depression. We performed a retrospective, pilot study evaluating patients who had not previously been on an antidepressant medication and who were started on an antidepressant while in the trauma surgical, cardiothoracic, or medical intensive care unit (ICU). Read More

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http://dx.doi.org/10.1155/2017/5804860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615950PMC
September 2017
6 Reads

Variability in Glycemic Control with Temperature Transitions during Therapeutic Hypothermia.

Crit Care Res Pract 2017 18;2017:4831480. Epub 2017 Sep 18.

Division of Adult Medicine, Department of Pharmacy Practice, Texas Tech University Health Sciences Center School of Pharmacy, 1300 S. Coulter St., Room 206, Amarillo, TX 79106, USA.

Purpose: Patients treated with therapeutic hypothermia (TH) and continuous insulin may be at increased risk of hyperglycemia or hypoglycemia, particularly during temperature transitions. This study aimed to evaluate frequency of glucose excursions during each phase of TH and to characterize glycemic control patterns in relation to survival.

Methods: Patients admitted to a tertiary care hospital for circulatory arrest and treated with both therapeutic hypothermia and protocol-based continuous insulin between January 2010 and June 2013 were included. Read More

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http://dx.doi.org/10.1155/2017/4831480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624133PMC
September 2017
7 Reads

Analysis of Adverse Events during Intrahospital Transportation of Critically Ill Patients.

Crit Care Res Pract 2017 14;2017:6847124. Epub 2017 Sep 14.

Department of Internal Medicine, Universidade Estadual de Londrina, Londrina, PR, Brazil.

Purpose: To describe adverse events occurring during intrahospital transportation of adult patients hospitalized in an Intensive Care Unit (ICU) and to evaluate the association with morbidity and mortality.

Method: Prospective cohort study from July 2014 to July 2015. Data collection comprised clinical data, prognostic scores, length of stay, and outcome at hospital discharge. Read More

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http://dx.doi.org/10.1155/2017/6847124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618745PMC
September 2017
13 Reads

IVC Measurements in Critically Ill Patients with Acute Renal Failure.

Crit Care Res Pract 2017 5;2017:3598392. Epub 2017 Sep 5.

University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Objective: To determine whether the inferior vena cava (IVC) measurement by bedside ultrasound (US-IVC) predicts improvement in renal function in patients with acute kidney injury (AKI).

Design: Prospective observational study.

Setting: Medical intensive care unit. Read More

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http://dx.doi.org/10.1155/2017/3598392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605903PMC
September 2017
6 Reads

Clinical Characteristics and Outcomes of Surgical Patients with Intensive Care Unit Lengths of Stay of 90 Days and Greater.

Crit Care Res Pract 2017 30;2017:9852017. Epub 2017 Jul 30.

Department of General and Visceral Surgery, University of Freiburg Medical Center, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.

Background: The aim of this study was to evaluate the influence of prolonged length of stay in an intensive care unit (ICU) on the mortality and morbidity of surgical patients.

Methods: We performed a monocentric and retrospective observational study in the surgical critical care unit of the department of surgery at the Medical Center of the University of Freiburg, Germany. Clinical data was collected from patients assigned to the ICU with a length of stay (LOS) of 90 days and greater. Read More

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http://dx.doi.org/10.1155/2017/9852017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554573PMC
July 2017
10 Reads

Utilisation of Intermediate Care Units: A Systematic Review.

Crit Care Res Pract 2017 9;2017:8038460. Epub 2017 Jul 9.

Division of Surgery, University Medical Centre Utrecht, Utrecht, Netherlands.

The diversity in formats of Intermediate Care Units (IMCUs) makes it difficult to compare data from different settings. The purpose of this article was to describe and quantify these different formations and utilisation. We performed a systematic review extracting geographic location, nomenclature used, admitting specialties, open (admitting specialist in charge) or closed (intensivist/generalist in charge) management format, location in hospital, number of beds, nursing workload, medical staff to patient ratios, and modalities-possibilities and limitations-implemented. Read More

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http://dx.doi.org/10.1155/2017/8038460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523340PMC
July 2017
35 Reads

Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence.

Crit Care Res Pract 2017 6;2017:3635609. Epub 2017 Jul 6.

Department of Medical Affairs, Wockhardt Ltd., Wockhardt Towers, Mumbai 400051, India.

Polymyxin B has resurged in recent years as a last resort therapy for Gram-negative multidrug-resistant (MDR) and extremely drug resistant (XDR) infections. Understanding newer evidence on polymyxin B is necessary to guide clinical decision making. Here, we present a literature review of polymyxin B in Gram-negative infections with update on its pharmacology. Read More

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http://dx.doi.org/10.1155/2017/3635609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518490PMC
July 2017
15 Reads

Factors Associated with the Incidence and Severity of New-Onset Atrial Fibrillation in Adult Critically Ill Patients.

Crit Care Res Pract 2017 15;2017:8046240. Epub 2017 Jun 15.

Hospital Bom Jesus, Toledo, PR, Brazil.

Background: Acute Atrial Fibrillation (AF) is common in critically ill patients, with significant morbidity and mortality; however, its incidence and severity in Intensive Care Units (ICUs) from low-income countries are poorly studied. Additionally, impact of vasoactive drugs on its incidence and severity is still not understood. This study aimed to assess epidemiology and risk factors for acute new-onset AF in critically ill adult patients and the role of vasoactive drugs. Read More

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https://www.hindawi.com/journals/ccrp/2017/8046240/
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http://dx.doi.org/10.1155/2017/8046240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494087PMC
June 2017
10 Reads

Melatonin Secretion Pattern in Critically Ill Patients: A Pilot Descriptive Study.

Crit Care Res Pract 2017 11;2017:7010854. Epub 2017 May 11.

Department of Anesthesia and Intensive Care Medicine, Odense University Hospital and Southern Danish University, Odense, Denmark.

Critically ill patients have abnormal circadian and sleep homeostasis. This may be associated with higher morbidity and mortality. The aims of this pilot study were (1) to describe melatonin secretion in conscious critically ill mechanically ventilated patients and (2) to describe whether melatonin secretion and sleep patterns differed in these patients with and without remifentanil infusion. Read More

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http://dx.doi.org/10.1155/2017/7010854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443994PMC
May 2017
17 Reads

Brain Multimodality Monitoring: A New Tool in Neurocritical Care of Comatose Patients.

Crit Care Res Pract 2017 7;2017:6097265. Epub 2017 May 7.

Department of Neurology, Stroke Division, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Neurocritical care patients are at risk of developing secondary brain injury from inflammation, ischemia, and edema that follows the primary insult. Recognizing clinical deterioration due to secondary injury is frequently challenging in comatose patients. Multimodality monitoring (MMM) encompasses various tools to monitor cerebral metabolism, perfusion, and oxygenation aimed at detecting these changes to help modify therapies before irreversible injury sets in. Read More

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http://dx.doi.org/10.1155/2017/6097265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438832PMC
May 2017
7 Reads

Impact of Delayed Admission to the Intensive Care Unit from the Emergency Department upon Sepsis Outcomes and Sepsis Protocol Compliance.

Crit Care Res Pract 2017 12;2017:9616545. Epub 2017 Mar 12.

Department of Pulmonary and Critical Care, St. Elizabeth's Medical Center, Tufts University, Boston, MA, USA.

. The impact of emergency department length of stay (EDLOS) upon sepsis outcomes needs clarification. We sought to better understand the relationship between EDLOS and both outcomes and protocol compliance in sepsis. Read More

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https://www.hindawi.com/journals/ccrp/2017/9616545/
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http://dx.doi.org/10.1155/2017/9616545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376419PMC
March 2017
6 Reads

The Benefit of Neuromuscular Blockade in Patients with Postanoxic Myoclonus Otherwise Obscuring Continuous Electroencephalography (CEEG).

Crit Care Res Pract 2017 6;2017:2504058. Epub 2017 Feb 6.

Department of Neurology, The University of Chicago Medicine, 5841 S. Maryland Drive, MC2030, Chicago, IL 60637, USA.

. Myoclonus status epilepticus is independently associated with poor outcome in coma patients after cardiac arrest. Determining if myoclonus is of cortical origin on continuous electroencephalography (CEEG) can be difficult secondary to the muscle artifact obscuring the underlying CEEG. Read More

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https://www.hindawi.com/journals/ccrp/2017/2504058/
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http://dx.doi.org/10.1155/2017/2504058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317108PMC
February 2017
15 Reads

Severe Tuberculosis Requiring Intensive Care: A Descriptive Analysis.

Crit Care Res Pract 2017 30;2017:9535463. Epub 2017 Jan 30.

Infectious Diseases Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, Porto, Portugal; Instituto de Inovação e Investigação em Saúde (I3S), Grupo de I&D em Nefrologia e Doenças Infecciosas, Instituto Nacional de Engenharia Biomédica (INEB), Porto, Portugal.

. This study aims to describe the characteristics of tuberculosis (TB) patients requiring intensive care and to determine the in-hospital mortality and the associated predictive factors. . Read More

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http://dx.doi.org/10.1155/2017/9535463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303839PMC
January 2017
12 Reads

Does Obesity Predispose Medical Intensive Care Unit Patients to Venous Thromboembolism despite Prophylaxis? A Retrospective Chart Review.

Crit Care Res Pract 2016 23;2016:3021567. Epub 2016 Nov 23.

Mayo Clinic, Rochester, MN, USA.

. Obesity is a significant issue in the critically ill population. There is little evidence directing the dosing of venous thromboembolism (VTE) prophylaxis within this population. Read More

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https://www.hindawi.com/journals/ccrp/2016/3021567/
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http://dx.doi.org/10.1155/2016/3021567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141306PMC
November 2016
11 Reads

Impact of a Local Low-Cost Ward-Based Response System in a Canadian Tertiary Care Hospital.

Crit Care Res Pract 2016 17;2016:1518760. Epub 2016 Oct 17.

Department of General Internal Medicine, Montreal General Hospital, McGill University Health Centre, Montreal, QC, Canada; Department of Critical Care, Montreal General Hospital, McGill University Health Centre, Montreal, QC, Canada; Department of Critical Care, Jewish General Hospital, Montreal, QC, Canada.

. Medical emergency teams (METs) or rapid response teams (RRTs) facilitate early intervention for clinically deteriorating hospitalized patients. In healthcare systems where financial resources and intensivist availability are limited, the establishment of such teams can prove challenging. Read More

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https://www.hindawi.com/journals/ccrp/2016/1518760/
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http://dx.doi.org/10.1155/2016/1518760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086497PMC
October 2016
10 Reads

Correlation between Arterial Lactate and Central Venous Lactate in Children with Sepsis.

Crit Care Res Pract 2016 16;2016:7839739. Epub 2016 Oct 16.

Pediatrics and Research Department, Universidad de la Sabana, Bogotá, Colombia.

. Lactate is an important indicator of tissue perfusion. The objective of this study is to evaluate if there are significant differences between the arterial and central venous measurement of lactate in pediatric patients with sepsis and/or septic shock. Read More

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http://dx.doi.org/10.1155/2016/7839739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086379PMC
October 2016
7 Reads

Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit.

Crit Care Res Pract 2016 9;2016:2610873. Epub 2016 Oct 9.

Department of Medicine, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, Uganda.

. In high-income countries, improved survival has been documented among intensive care unit (ICU) patients infected with human immune deficiency virus (HIV). There are no data from low-income country ICUs. Read More

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http://dx.doi.org/10.1155/2016/2610873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075298PMC
October 2016
25 Reads

Potentially Preventable Deaths by Intensive Care Medicine in Mongolian Hospitals.

Crit Care Res Pract 2016 4;2016:8624035. Epub 2016 Oct 4.

Department of Critical Care, University College of London Hospital, London NW1 2BU, UK.

. To evaluate the portion of hospitalized patients dying without prior intensive care unit (ICU) admission and assess whether death could have been prevented by intensive care. . Read More

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http://dx.doi.org/10.1155/2016/8624035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067316PMC
October 2016
6 Reads

Abnormal Admission Chest X-Ray and MEWS as ICU Outcome Predictors in a Sub-Saharan Tertiary Hospital: A Prospective Observational Study.

Crit Care Res Pract 2016 19;2016:7134854. Epub 2016 Sep 19.

Directorate of Surgery Surgical Services, Mulago National Referral Hospital, Kampala, Uganda.

. Critical care in Uganda is a neglected speciality and deemed costly with limited funding/prioritization. We studied admission X-ray and MEWS as mortality predictors of ICU patients requiring mechanical ventilation. Read More

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https://www.hindawi.com/journals/ccrp/2016/7134854/
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http://dx.doi.org/10.1155/2016/7134854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045988PMC
September 2016
16 Reads

The Development of Intensive Care Unit Acquired Hypernatremia Is Not Explained by Sodium Overload or Water Deficit: A Retrospective Cohort Study on Water Balance and Sodium Handling.

Crit Care Res Pract 2016 14;2016:9571583. Epub 2016 Sep 14.

Department of Intensive Care, Medical Centre Leeuwarden, P.O. Box 888, 8901 BK Leeuwarden, Netherlands.

. ICU acquired hypernatremia (IAH, serum sodium concentration (sNa) ≥ 143 mmol/L) is mainly considered iatrogenic, induced by sodium overload and water deficit. Main goal of the current paper was to answer the following questions: Can the development of IAH indeed be explained by sodium intake and water balance? Or can it be explained by renal cation excretion? Two retrospective studies were conducted: a balance study in 97 ICU patients with and without IAH and a survey on renal cation excretion in 115 patients with IAH. Read More

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https://www.hindawi.com/journals/ccrp/2016/9571583/
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040124PMC
http://dx.doi.org/10.1155/2016/9571583DOI Listing
September 2016
13 Reads