22,225 results match your criteria Critical care medicine[Journal]


Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 (BMS-936559).

Crit Care Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Anesthesiology, Innovative Medicines Development, Bristol-Myers Squibb, Princeton, NJ.

Objectives: To assess for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 immune checkpoint inhibitor (BMS-936559, Bristol-Myers Squibb, Princeton, NJ) and its effect on immune biomarkers in participants with sepsis-associated immunosuppression.

Design: Randomized, placebo-controlled, dose-escalation.

Setting: Seven U. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003685DOI Listing
February 2019

Study of the Effects of Epinephrine on Cerebral Oxygenation and Metabolism During Cardiac Arrest and Resuscitation by Hyperspectral Near-Infrared Spectroscopy.

Crit Care Med 2019 Feb 8. Epub 2019 Feb 8.

Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Objectives: Epinephrine is routinely administered to sudden cardiac arrest patients during resuscitation, but the neurologic effects on patients treated with epinephrine are not well understood. This study aims to assess the cerebral oxygenation and metabolism during ventricular fibrillation cardiac arrest, cardiopulmonary resuscitation, and epinephrine administration.

Design: To investigate the effects of equal dosages of IV epinephrine administrated following sudden cardiac arrest as a continuous infusion or successive boluses during cardiopulmonary resuscitation, we monitored cerebral oxygenation and metabolism using hyperspectral near-infrared spectroscopy. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003640DOI Listing
February 2019

Outcomes After Extracorporeal Cardiopulmonary Resuscitation of Pediatric In-Hospital Cardiac Arrest: A Report From the Get With the Guidelines-Resuscitation and the Extracorporeal Life Support Organization Registries.

Crit Care Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: The aim of this study was to determine cardiac arrest- and extracorporeal membrane oxygenation-related risk factors associated with unfavorable outcomes after extracorporeal cardiopulmonary resuscitation.

Design: We performed an analysis of merged data from the Extracorporeal Life Support Organization and the American Heart Association Get With the Guidelines-Resuscitation registries.

Setting: A total of 32 hospitals reporting to both registries between 2000 and 2014. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003622DOI Listing
February 2019

Neutropenic Enterocolitis in Critically Ill Patients: Spectrum of the Disease and Risk of Invasive Fungal Disease.

Crit Care Med 2019 Feb 7. Epub 2019 Feb 7.

Medical Intensive Care Unit, Hospital Saint Louis, Assistance Publique - Hôpitaux de Paris, France.

Objectives: Neutropenic enterocolitis occurs in about 5.3% of patients hospitalized for hematologic malignancies receiving chemotherapy. Data from critically ill patients with neutropenic enterocolitis are scarce. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003687DOI Listing
February 2019

The Effect of Mechanical Ventilation on Peripheral Perfusion Index and Its Association With the Prognosis of Critically Ill Patients.

Crit Care Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Objectives: This study aimed to explore the relationship between the variables of mechanical ventilation and circulatory perfusion and its association with ICU mortality during the first day of mechanical ventilation.

Design: Retrospective cohort study.

Setting: The Department of Critical Care Medicine, Peking Union Medical College Hospital. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003661DOI Listing
February 2019
2 Reads

Central Venous Access Capability and Critical Care Telemedicine Decreases Inter-Hospital Transfer Among Severe Sepsis Patients: A Mixed Methods Design.

Crit Care Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA.

Objectives: Severe sepsis is a complex, resource intensive, and potentially lethal condition and rural patients have worse outcomes than urban patients. Early identification and treatment are important to improving outcomes. The objective of this study was to identify hospital-specific factors associated with inter-hospital transfer. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003686DOI Listing
February 2019
1 Read

Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study.

Crit Care Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Anesthesiology and Intensive Care Medicine, University of Tübingen, Tübingen, Germany.

Objectives: Sepsis is associated with a systemic inflammatory reaction, which can result in a life-endangering organ dysfunction. Pro-inflammatory responses during sepsis are characterized by increased activation of leukocytes and platelets, formation of platelet-neutrophil aggregates, and cytokine production. Sequestration of platelet-neutrophil aggregates in the microvasculature contributes to tissue damage during sepsis. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003682DOI Listing
February 2019
2 Reads

Circulating Secretoneurin Concentrations After Cardiac Surgery: Data From the FINNish Acute Kidney Injury Heart Study.

Crit Care Med 2019 Feb 5. Epub 2019 Feb 5.

Division of Medicine, Akershus University Hospital, Lørenskog, Norway.

Objectives: Secretoneurin is associated with cardiomyocyte Ca handling and improves risk prediction in patients with acute myocardial dysfunction. Whether secretoneurin improves risk assessment on top of established cardiac biomarkers and European System for Cardiac Operative Risk Evaluation II in patients undergoing cardiac surgery is not known.

Design: Prospective, observational, single-center sub-study of a multicenter study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003670DOI Listing
February 2019
1 Read

Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis.

Crit Care Med 2019 Feb 5. Epub 2019 Feb 5.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC.

Objectives: Metabolic derangements in sepsis stem from mitochondrial injury and contribute significantly to organ failure and mortality; however, little is known about mitochondrial recovery in human sepsis. We sought to test markers of mitochondrial injury and recovery (mitochondrial biogenesis) noninvasively in peripheral blood mononuclear cells from patients with sepsis and correlate serial measurements with clinical outcomes.

Design: Prospective case-control study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003681DOI Listing
February 2019
1 Read

The Effect of Goal-Directed Therapy on Patient Morbidity and Mortality After Traumatic Brain Injury, Results From the Progesterone for the Treatment of Traumatic Brain Injury III Clinical Trial.

Crit Care Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA.

Objectives: To estimate the impact of goal-directed therapy on outcome after traumatic brain injury, our team applied goal-directed therapy to standardize care in patients with moderate to severe traumatic brain injury, who were enrolled in a large multicenter clinical trial.

Design: Planned secondary analysis of data from Progesterone for the Treatment of Traumatic Brain Injury III, a large, prospective, multicenter clinical trial.

Setting: Forty-two trauma centers within the Neurologic Emergencies Treatment Trials network. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003680DOI Listing
February 2019

ICU Utilization for Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease Receiving Noninvasive Ventilation.

Crit Care Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA.

Objectives: We investigated whether patients with chronic obstructive pulmonary disease could safely receive noninvasive ventilation outside of the ICU.

Design: Retrospective cohort study.

Setting: Twelve states with ICU utilization flag from the State Inpatient Database from 2014. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003660DOI Listing
February 2019
2 Reads

Impact of the Advanced Practice Provider in Adult Critical Care: A Systematic Review and Meta-Analysis.

Crit Care Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands.

Objectives: To evaluate the effects on quality and efficiency of implementation of the advanced practice provider in critical care.

Data Sources: PubMed, Embase, The Cochrane Library, and CINAHL were used to extract articles regarding advanced practice providers in critical care.

Study Selection: Articles were selected when reporting a comparison between advanced practice providers and physician resident/fellows regarding the outcome measures of mortality, length of stay, or specific tasks. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003667DOI Listing
February 2019

Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients.

Crit Care Med 2019 Feb 1. Epub 2019 Feb 1.

Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Objectives: Cellular Immunotherapy for Septic Shock is the first-in-human clinical trial evaluating allogeneic mesenchymal stem/stromal cells in septic shock patients. Here, we sought to determine whether plasma cytokine profiles may provide further information into the safety and biological effects of mesenchymal stem/stromal cell treatment, as no previous study has conducted a comprehensive analysis of circulating cytokine levels in critically ill patients treated with mesenchymal stem/stromal cells.

Design: Phase 1 dose-escalation trial. Read More

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http://Insights.ovid.com/crossref?an=00003246-900000000-9602
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http://dx.doi.org/10.1097/CCM.0000000000003657DOI Listing
February 2019
6 Reads

Enhanced Performance of Next-Generation Sequencing Diagnostics Compared With Standard of Care Microbiological Diagnostics in Patients Suffering From Septic Shock.

Crit Care Med 2019 Feb 1. Epub 2019 Feb 1.

Fraunhofer IGB, Stuttgart, Germany.

Objectives: Culture-based diagnostics represent the standard of care in septic patients, but are highly insensitive and in many cases unspecific. We recently demonstrated the general feasibility of next-generation sequencing-based diagnostics using free circulating nucleic acids (cell-free DNA) in plasma samples of septic patients. Within the presented investigation, higher performance of next-generation sequencing-based diagnostics was validated by comparison to matched blood cultures. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003658DOI Listing
February 2019
2 Reads

Compared Efficacy of Four Preoxygenation Methods for Intubation in the ICU: Retrospective Analysis of McGrath Mac Videolaryngoscope Versus Macintosh Laryngoscope (MACMAN) Trial Data.

Crit Care Med 2019 Jan 30. Epub 2019 Jan 30.

Medical Intensive Care Unit, University Hospital, Nantes, France.

Objectives: Severe hypoxemia is the most common serious adverse event during endotracheal intubation. Preoxygenation is performed routinely as a preventive measure. The relative efficacy of the various available preoxygenation devices is unclear. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003656DOI Listing
January 2019
1 Read

Intensivists in U.S. Acute Care Hospitals.

Crit Care Med 2019 Jan 25. Epub 2019 Jan 25.

Critical Care Center, Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Objectives: To determine the total numbers of privileged and full-time equivalent intensivists in acute care hospitals with intensivists and compare the characteristics of hospitals with and without intensivists.

Design: Retrospective analysis of the American Hospital Association Annual Survey Database (Fiscal Year 2015).

Setting: Two-thousand eight-hundred fourteen acute care hospitals with ICU beds. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003615DOI Listing
January 2019
2 Reads

Evaluating Tele-ICU Implementation Based on Observed and Predicted ICU Mortality: A Systematic Review and Meta-Analysis.

Crit Care Med 2019 Jan 24. Epub 2019 Jan 24.

eHealth Center, Westchester Medical Center Health Network, Valhalla, NY.

Objectives: Past studies have examined numerous components of tele-ICU care to decipher which elements increase patient and institutional benefit. These factors include review of the patient chart within 1 hour, frequent collaborative data reviews, mechanisms for rapid laboratory/alert review, and interdisciplinary rounds. Previous meta-analyses have found an overall ICU mortality benefit implementing tele-ICU, however, subgroup analyses found few differences. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003627DOI Listing
January 2019

Effect of Antihypertensive Medications on Sepsis-Related Outcomes: A Population-Based Cohort Study.

Crit Care Med 2019 Jan 24. Epub 2019 Jan 24.

Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.

Objectives: Although the effect of antihypertensive agents on sepsis has been studied, evidence for survival benefit was limited in the literature. We investigated differences in sepsis-related outcomes depending on the antihypertensive drugs given prior to sepsis in patients with hypertension.

Design: Population-based cohort study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003654DOI Listing
January 2019
1 Read

Workforce, Workload, and Burnout Among Intensivists and Advanced Practice Providers: A Narrative Review.

Crit Care Med 2019 Jan 24. Epub 2019 Jan 24.

Department of Critical Care Medicine, MD Anderson Cancer Center, Houston, TX., †Deceased.

Objectives: To assess-by literature review and expert consensus-workforce, workload, and burnout considerations among intensivists and advanced practice providers.

Design: Data were synthesized from monthly expert consensus and literature review.

Setting: Workforce and Workload section workgroup of the Academic Leaders in Critical Care Medicine Task Force. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003637DOI Listing
January 2019
5 Reads

Effects of Positive End-Expiratory Pressure and Spontaneous Breathing Activity on Regional Lung Inflammation in Experimental Acute Respiratory Distress Syndrome.

Crit Care Med 2019 Jan 22. Epub 2019 Jan 22.

Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Objectives: To determine the impact of positive end-expiratory pressure during mechanical ventilation with and without spontaneous breathing activity on regional lung inflammation in experimental nonsevere acute respiratory distress syndrome.

Design: Laboratory investigation.

Setting: University hospital research facility. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003649DOI Listing
January 2019
1 Read

Readmission Diagnoses After Pediatric Severe Sepsis Hospitalization.

Crit Care Med 2019 Jan 22. Epub 2019 Jan 22.

Department of Medicine, University of Michigan Health System, Ann Arbor, MI.

Objectives: Severe sepsis is a significant cause of healthcare use and morbidity among pediatric patients, but little is known about readmission diagnoses. We sought to determine the most common readmission diagnoses after pediatric severe sepsis, the extent to which post-sepsis readmissions may be potentially preventable, and whether patterns of readmission diagnoses differ compared with readmissions after other common acute medical hospitalizations.

Design: Observational cohort study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003646DOI Listing
January 2019
3 Reads

Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

Crit Care Med 2019 Jan 21. Epub 2019 Jan 21.

Metrum Research Group, Tariffville, CT.

Objectives: To develop a pharmacokinetic-pharmacogenomic population model of midazolam in critically ill children with primary respiratory failure.

Design: Prospective pharmacokinetic-pharmacogenomic observational study.

Setting: Thirteen PICUs across the United States. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003638DOI Listing
January 2019
1 Read

The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.

Crit Care Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Aging & Geriatric Research, University of Florida, Gainesville, FL.

Objectives: This study sought to examine mortality, health-related quality of life, and physical function among sepsis survivors who developed chronic critical illness.

Design: Single-institution, prospective, longitudinal, observational cohort study assessing 12-month outcomes.

Setting: Two surgical/trauma ICUs at an academic tertiary medical and level 1 trauma center. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003655DOI Listing
January 2019
7 Reads

Respiratory Variability of Pulmonary Velocity-Time Integral As a New Gauge of Fluid Responsiveness For Mechanically Ventilated Patients in the ICU.

Crit Care Med 2019 Jan 18. Epub 2019 Jan 18.

Medical-surgical intensive care unit, Centre hospitalier de Bretagne Sud, Lorient, France.

Objectives: To evaluate reliability and feasibility of the respiratory variability of pulmonary velocity-time integral as a new dynamic marker of fluid responsiveness in mechanically ventilated patients.

Design: Prospective observational study.

Setting: Medical-surgical ICU of a general hospital. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003642DOI Listing
January 2019
2 Reads

Validation and Critical Evaluation of the Effective Arterial Elastance in Critically Ill Patients.

Crit Care Med 2019 Jan 17. Epub 2019 Jan 17.

Inserm UMR S_999, Univ Paris-Sud, Le Kremlin-Bicêtre, F-94270 France.

Objectives: First, to validate bedside estimates of effective arterial elastance = end-systolic pressure/stroke volume in critically ill patients. Second, to document the added value of effective arterial elastance, which is increasingly used as an index of left ventricular afterload.

Design: Prospective study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003645DOI Listing
January 2019
1 Read

A Rare Case of Meningitis in an Immunocompetent Adult.

Indian J Crit Care Med 2018 Dec;22(12):892-893

Department of Critical Care, Columbia Asia Referral Hospital, Bengaluru, Karnataka, India.

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http://dx.doi.org/10.4103/ijccm.IJCCM_173_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311980PMC
December 2018
1 Read

Junctional Rhythm: A Rare Sign in Leptospirosis.

Indian J Crit Care Med 2018 Dec;22(12):889-891

Department of Radiation Oncology, RIMS, Ranchi, Jharkhand, India.

Leptospirosis is an important re-emerging infectious disease. Leptospirosis has been estimated to affect tens of millions of humans annually with a case fatality rate ranging from 5% to 25%; however, it is underreported due to the lack of clinical suspicion and barriers to diagnostic capacity. A 33-year-old healthy male presented with a history of fever of 2-day duration. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_437_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311981PMC
December 2018
2 Reads

Multiple Splenic Abscesses in a Case of Enteric Fever: Salvaging Spleen through Pigtail Drainage and Antibiotics is a Good Alternative Approach.

Indian J Crit Care Med 2018 Dec;22(12):886-888

Department of Medicine, Command Hospital Air Force, Bengaluru, Karnataka, India.

Splenic abscess is a rare complication of enteric fever in developing countries. This is seen mostly solitary rather than being multiple and can be fatal if untreated. In general clinical practice, multiple splenic abscesses or thick pus with septations may require splenectomy. Read More

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http://www.ijccm.org/text.asp?2018/22/12/886/247749
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http://dx.doi.org/10.4103/ijccm.IJCCM_405_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311984PMC
December 2018
3 Reads

Extreme Metabolic Alkalosis and Acute Kidney Injury in a 38-Year-Old Male Patient.

Indian J Crit Care Med 2018 Dec;22(12):883-885

Department of Internal Medicine, Stuttgart Hospital, Stuttgart, Germany.

Repeated vomiting may lead to profound loss of fluid and electrolytes. We describe a case with life-threatening acid-base disturbances due to vomiting. A 38-year-old man presented to an emergency department with weakness and decreased urine output after having vomited up to 20 times per day over a period of 7 days. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_180_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311974PMC
December 2018
2 Reads

Bilateral Lower Cranial Nerve Palsy after Closed Head Injury: A Case Report and Review of Literature.

Indian J Crit Care Med 2018 Dec;22(12):879-882

Department of Critical Care Medicine, Narayana Multispeciality Hospital, Bengaluru, Karnataka, India.

Paralysis of the lower cranial nerves is uncommon after closed head injuries. Most cases reported are unilateral and associated with base of skull fractures, usually involving the occipital condyles. Bilateral lower cranial nerve palsy is even less common, with only a handful of cases reported in literature. Read More

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http://www.ijccm.org/text.asp?2018/22/12/879/247753
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http://dx.doi.org/10.4103/ijccm.IJCCM_476_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311977PMC
December 2018
5 Reads

Dilemmas and Challenges in Treating Seronegative Autoimmune Encephalitis in Indian Children.

Indian J Crit Care Med 2018 Dec;22(12):875-878

Department of Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Objective: The main objective is to assess the challenges in diagnosis and treatment while managing seronegative cases of autoimmune encephalitis (AIE) in Indian children.

Methods: A cohort study of patients with AIE was done where clinical presentations, investigations, management were analyzed and these patients were followed up to assess the evolution of the disease.

Results: Nine patients were included in the study. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_98_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311983PMC
December 2018
2 Reads

Management of Symmetrical Peripheral Gangrene.

Indian J Crit Care Med 2018 Dec;22(12):870-874

Department of Surgery, School of Medicine, Perdana University-Royal College of Surgeons Ireland Selangor, Malaysia.

Symmetrical peripheral gangrene (SPG) is a rare, debilitating disease that deserves more widespread concern among the medical fraternities. The objective of this review is to outline the etiology, pathology findings, and management practices of SPG. About 18%-40% mortality rate was reported, and survivors have high frequency of multiple limb amputations. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_379_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311972PMC
December 2018
4 Reads

Extracorporeal Treatment in the Management of Acute Poisoning: What an Intensivist Should Know?

Indian J Crit Care Med 2018 Dec;22(12):862-869

Department of Medicine, INHS Kalyani, Visakhapatnam, Andhra Pradesh, India.

Extracorporeal treatment (ECTR) represents a treatment modality promoting removal of endogenous or exogenous poisons and supporting or temporarily replacing a vital organ. This article aims to provide a brief overview of the technical aspects and the potential indications and limitations of the different ECTRs, highlighting the important characteristics of poison amenable to ECTR and the most appropriate prescriptions used in the setting of acute poisoning. The various principles that govern poison elimination by ECTR (diffusion, convection, adsorption, and centrifugation) and how components of the ECTR can be adjusted to maximize clearance have also being discussed. Read More

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http://www.ijccm.org/text.asp?2018/22/12/862/247750
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http://dx.doi.org/10.4103/ijccm.IJCCM_425_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311976PMC
December 2018
5 Reads

An Intervention Study for the Prevention and Control of Health Care-Associated Infection in the Critical Cares Area of a Tertiary Care Hospital in Saudi Arabia.

Indian J Crit Care Med 2018 Dec;22(12):858-861

Al Rass General Hospital, Al Raas, Saudi Arabia.

Introduction: Healthcare-associated infections (HAIs) are an infection that patients acquire during receiving treatment and care for the medical or surgical problem.

Objective: The objective of this study is to find the patterns of HAIs cases in the hospital and to know the impact of the intervention on prevention and control of health care associated infection.

Methodology: This was prospective interventional study. Read More

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http://www.ijccm.org/text.asp?2018/22/12/858/247744
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http://dx.doi.org/10.4103/ijccm.IJCCM_270_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311973PMC
December 2018
5 Reads

Six-Hour Sepsis Bundle Decreases Mortality: Truth or Illusion - A Prospective Observational Study.

Indian J Crit Care Med 2018 Dec;22(12):852-857

Department of Pediatrics, St. Stephen's Hospital, Delhi, India.

Aim: The aim of the study is to evaluate whether 6-h sepsis bundle component compliance (complete vs. incomplete) decreases mortality in pediatric patients with severe sepsis and septic shock.

Methodology: The study was conducted at a tertiary care hospital. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_147_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311982PMC
December 2018
2 Reads

The Utilization of the Surviving Sepsis Campaign Care Bundles in the Treatment of Pediatric Patients with Severe Sepsis or Septic Shock in a Resource-Limited Environment: A Prospective Multicenter Trial.

Indian J Crit Care Med 2018 Dec;22(12):846-851

Division of Pediatric Pulmonary and Critical Care, Vachira Hospital, Bangkok, Thailand.

Background: Sepsis is a common condition affecting the lives of infants and children worldwide. Although implementation of the surviving sepsis campaign (SSC) care bundles was once believed to be effective in reducing sepsis mortality rates, the approach has recently been questioned.

Methods: The study was a prospective, interventional, multicenter trial. Read More

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http://www.ijccm.org/text.asp?2018/22/12/846/247746
Publisher Site
http://dx.doi.org/10.4103/ijccm.IJCCM_367_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311978PMC
December 2018
3 Reads

Comparison of Various Severity Assessment Scoring Systems in Patients with Sepsis in a Tertiary Care Teaching Hospital.

Indian J Crit Care Med 2018 Dec;22(12):842-845

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India.

Background: Sepsis is a complex condition defined by the systemic response to infection. Severity assessment scoring systems are used to aid the physician in deciding whether aggressive treatment is needed or not. In this study, various severity assessment scoring systems, namely Acute Physiology and Chronic Health Evaluation II (APACHE II), Rapid Emergency Medicine Score (REMS), Sequential Organ Failure Assessment (SOFA), Multiple Organ Dysfunction Score (MODS), Predisposition, Infection, Response, and Organ Dysfunction (PIRO), and Mortality in Emergency Department Sepsis (MEDS), were compared to assess their sensitivity and specificity. Read More

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http://www.ijccm.org/text.asp?2018/22/12/842/247745
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http://dx.doi.org/10.4103/ijccm.IJCCM_322_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311975PMC
December 2018
10 Reads

Comparison of Hemodynamic Monitoring between Transesophageal Doppler and Ultrasonography-Guided Inferior Vena Cava Distensibility in Supine versus Prone Position: A Pilot Study.

Indian J Crit Care Med 2018 Dec;22(12):836-841

Department of Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Introduction: Lung-protective ventilation strategy and prone positioning are the strategies practiced to manage patients suffering from acute respiratory distress syndrome (ARDS). Inferior Vena Cava Distensibility (dIVC) Index has been used for predicting fluid responsiveness (FR) in supine position. We conducted this study to observe the utility of dIVC in prone position in ARDS patients and compare it with esophageal Doppler (ED) parameters. Read More

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http://www.ijccm.org/text.asp?2018/22/12/836/247751
Publisher Site
http://dx.doi.org/10.4103/ijccm.IJCCM_432_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311971PMC
December 2018
5 Reads

Acute Kidney Injury in Malaysian Intensive Care Setting: Incidences, Risk Factors, and Outcome.

Indian J Crit Care Med 2018 Dec;22(12):831-835

Department of Anaesthesiology and Intensive Care, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.

Introduction: Acute kidney injury (AKI) is common in the intensive care unit (ICU) with a high risk of morbidity and mortality. The high incidence of AKI in our population may be attributed to sepsis. We investigated the incidence, risk factors, and outcome of AKI in four tertiary Malaysian ICUs. Read More

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http://www.ijccm.org/text.asp?2018/22/12/831/247743
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http://dx.doi.org/10.4103/ijccm.IJCCM_193_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311985PMC
December 2018
5 Reads

Turnaround Time for Red Blood Cell Transfusion in the Hospitalized Patient: A Single-Center "Blood Ordering, Requisitioning, Blood Bank, Issue (of Blood), and Transfusion Delay" Study.

Indian J Crit Care Med 2018 Dec;22(12):825-830

Department of Blood Transfusion Medicine, Nayati Medicity, Mathura, Uttar Pradesh, India.

Background And Aim: The turnaround time (TAT) for blood transfusion (BT) is an important quality indicator for the health-care institutions undertaking this procedure. There is no established national or international benchmark for this TAT due to the dearth of a published literature. We thus studied the TAT and the contributory procedures leading to delay in commencing a red blood cell transfusion in the hospitalized patient. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_403_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311979PMC
December 2018
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Risk Factors for New-Onset Atrial Fibrillation in Patients With Sepsis: A Systematic Review and Meta-Analysis.

Crit Care Med 2019 Feb;47(2):280-287

Department of Medicine, Boston University School of Medicine, The Pulmonary Center, Boston, MA.

Objective: Atrial fibrillation frequently develops in patients with sepsis and is associated with increased morbidity and mortality. Unfortunately, risk factors for new-onset atrial fibrillation in sepsis have not been clearly elucidated. Clarification of the risk factors for atrial fibrillation during sepsis may improve our understanding of the mechanisms of arrhythmia development and help guide clinical practice. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003560DOI Listing
February 2019
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Impact of Altered Airway Pressure on Intracranial Pressure, Perfusion, and Oxygenation: A Narrative Review.

Crit Care Med 2019 Feb;47(2):254-263

Translational Medicine, The Research Institute, Hospital for Sick Children, Toronto, ON, Canada.

Objectives: A narrative review of the pathophysiology linking altered airway pressure and intracranial pressure and cerebral oxygenation.

Data Sources: Online search of PubMed and manual review of articles (laboratory and patient studies) of the altered airway pressure on intracranial pressure, cerebral perfusion, or cerebral oxygenation.

Study Selection: Randomized trials, observational and physiologic studies. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003558DOI Listing
February 2019
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Transcranial Doppler in the Diagnosis of Cerebral Vasospasm: A Call for a Dynamic Approach.

Crit Care Med 2019 Feb;47(2):e164-e165

Service d'Anesthésie-Réanimation, Hôpital Laënnec, Centre Hospitalier Universitaire, Nantes, France.

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http://dx.doi.org/10.1097/CCM.0000000000003459DOI Listing
February 2019
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Is Helmet Noninvasive Ventilation a Protective Factor for Long-Term Outcome in Acute Respiratory Distress Syndrome?

Crit Care Med 2019 Feb;47(2):e164

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwell Health, Lenox Hill Hospital, New York, NY; Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwell Health, Lenox Hill Hospital, New York, NY.

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http://dx.doi.org/10.1097/CCM.0000000000003458DOI Listing
February 2019
5 Reads

Corticosteroids in Sepsis: Clouded by Heterogeneity.

Crit Care Med 2019 Feb;47(2):e163-e164

Department of Intensive Care, Amsterdam University Medical Centers, Location VUmc, Amsterdam, The Netherlands, and Department of Anesthesiology, Zaans Medisch Centrum, Zaandam, The Netherlands; Department of Intensive Care, Amsterdam University Medical Centers, Location VUmc, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000003513DOI Listing
February 2019
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The authors reply.

Crit Care Med 2019 Feb;47(2):e162-e163

School of Nursing and Midwifery, Menzies Health Institute Queensland, Griffith University, QLD, Australia; Department of Public Health, College of Health Sciences, Qatar University, Doha, Qatar; Menzies Health Institute Queensland, Griffith University, QLD, Australia; Intensive Care Services, Royal Brisbane and Women's Hospital and School of Nursing, Queensland University of Technology, Brisbane, QLD, Australia, and Institute for Skin Integrity and Infection Prevention, University of Huddersfield, Huddersfield, United Kingdom; Department of Internal Medicine, Ghent University, Ghent, Belgium, and Burns, Trauma and Critical Care Research Centre, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia; Menzies Health Institute Queensland, Griffith University, QLD, Australia; Department of Medical-Surgical Nursing, School of Nursing, University of Saõ Paulo, Saõ Paulo, Brazil; School of Nursing and Midwifery, Menzies Health Institute Queensland, Griffith University, QLD, Australia.

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http://dx.doi.org/10.1097/CCM.0000000000003565DOI Listing
February 2019
2 Reads

Pressure Injury Research in the ICU: Getting Rid of a Black Spot.

Crit Care Med 2019 Feb;47(2):e161-e162

Faculty of Medicine & Health Science, Ghent University, Belgium, and Faculty of Education, Health and Social Work, University College Ghent, Belgium; Rosie NICU, Cambridge University Hospitals, Cambridge, United Kingdom, and Faculty of Medicine & Health Science, Ghent University, Belgium; Universitat Internacional de Cataluña, Barcelona, Spain, and Faculty of Medicine and Health Sciences, Spain.

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http://dx.doi.org/10.1097/CCM.0000000000003512DOI Listing
February 2019
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The authors reply.

Crit Care Med 2019 Feb;47(2):e161

Kadoorie Centre for Critical Care Research, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, and Adult Intensive Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Department of Health and Life Science, Coventry University, Coventry, United Kingdom.

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http://dx.doi.org/10.1097/CCM.0000000000003568DOI Listing
February 2019
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Risks of Misunderstanding Results.

Authors:
Takashi Ariie

Crit Care Med 2019 Feb;47(2):e160-e161

Department of Rehabilitation, Takagi Hospital, Okawa-shi, Fukuoka, Japan.

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http://dx.doi.org/10.1097/CCM.0000000000003510DOI Listing
February 2019
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The authors reply.

Crit Care Med 2019 Feb;47(2):e159-e160

Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada; Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada, and Division of Palliative Care Medicine, Department of Oncology, University of Calgary, Calgary, AB, Canada; Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1097/CCM.0000000000003543DOI Listing
February 2019
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