22,363 results match your criteria Critical care medicine[Journal]


Fresh Red Cells for Transfusion in Critically Ill Adults: An Economic Evaluation of the Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Clinical Trial.

Crit Care Med 2019 Apr 18. Epub 2019 Apr 18.

Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Objectives: Trials comparing the effects of transfusing RBC units of different storage durations have considered mortality or morbidity as outcomes. We perform the first economic evaluation alongside a full age of blood clinical trial with a large population assessing the impact of RBC storage duration on quality-of-life and costs in critically ill adults.

Design: Quality-of-life was measured at 6 months post randomization using the EuroQol 5-dimension 3-level instrument. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003781DOI Listing
April 2019
1 Read

Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Objectives: To determine whether circulating endothelial cells from septic shock patients and from nonseptic shock patients are transformed in activated fibroblast by changing the expression level of endothelial and fibrotic proteins, whether the level of the protein expression change is associated with the amount of administered resuscitation fluid, and whether this circulating endothelial cell protein expression change is a biomarker to predict sepsis survival.

Design: Prospective study.

Setting: Medical-surgical ICUs in a tertiary care hospital. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003778DOI Listing

Angiotensin II: Time to Study Starting a Stopped Heart.

Crit Care Med 2019 May;47(5):e436

Division of Pulmonary & Critical Care Medicine, Department of Medicine and Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD Center for Critical Care and Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic Foundation, Cleveland, OH Department of Pulmonary, Critical Care, Allergy and Sleep Medicine, Emory University, Atlanta, GA.

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http://dx.doi.org/10.1097/CCM.0000000000003652DOI Listing
May 2019
1 Read

The authors reply.

Crit Care Med 2019 May;47(5):e435-e436

Department of Pharmacy, West Virginia University Medicine, Morgantown, WV Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY.

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http://dx.doi.org/10.1097/CCM.0000000000003706DOI Listing

Thiamine and Difficulties in Differentiating Type A From B Lactic Acidosis.

Crit Care Med 2019 May;47(5):e434-e435

Division of Pulmonary & Critical Care Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.

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http://dx.doi.org/10.1097/CCM.0000000000003684DOI Listing
May 2019
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Authors:
Gordon S Doig

Crit Care Med 2019 May;47(5):e434

University of Sydney's Northern Clinical School Intensive Care Research Unit, Royal North Shore Hospital ICU, St Leonards, NSW, Australia.

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http://dx.doi.org/10.1097/CCM.0000000000003694DOI Listing

Really Early Enteral Nutrition Reduces Mortality in Patients With Major Burn Injury.

Crit Care Med 2019 May;47(5):e433-e434

Respiratory Department, Hangzhou Third Hospital, Hangzhou, China.

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http://dx.doi.org/10.1097/CCM.0000000000003668DOI Listing

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Crit Care Med 2019 May;47(5):e432-e433

Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, University of Rome, "La Sapienza," Policlinico Umberto Primo, Viale del Policlinico, Rome, Italy Department of Anesthesia and Intensive Care, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Via Ernesto Tricomi, Palermo, Italy Department of Anesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, Protestant Hospital of the Bethel Foundation, Bielefeld, Germany Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Muenster, Germany.

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http://dx.doi.org/10.1097/CCM.0000000000003698DOI Listing

On the Right Track, Finally?

Crit Care Med 2019 May;47(5):e431-e432

Department of Critical Care, Hopital Desgenettes, Lyon, France Department of Epidemiology, EpiSmart, Basel, Switzerland Department of Physiology, INSA de Lyon, France Department of Critical Care, Hopital Louis Pasteur, Dole, France Department of Critical Care, JF Kennedy North Campus, West Palm Beach, FL Department of Critical Care, Hopital Desgenettes, Lyon, France.

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http://dx.doi.org/10.1097/CCM.0000000000003653DOI Listing

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Crit Care Med 2019 May;47(5):e430-e431

Department of Psychology, University of Manitoba, Winnipeg, MB, Canada, and Department of Clinical Health Psychology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada Department of Psychiatry, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1097/CCM.0000000000003697DOI Listing

Preventing Mental Health Symptoms in Post ICU Patients and Their Family Members.

Crit Care Med 2019 May;47(5):e429-e430

Fellow Neuroanesthesia & Critical Care, Liverpool, United Kingdom, and Department of Anesthesia & Intensive Care, All India Institute of Medical Sciences, Bhubaneswar, India Department of Psychiatry, Black County Partnership NHS Foundation Trust, Wolverhampton, United Kingdom.

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http://dx.doi.org/10.1097/CCM.0000000000003651DOI Listing
May 2019
1 Read

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Crit Care Med 2019 May;47(5):e429

Department of Surgery and the Program in Trauma, University of Maryland School of Medicine, Baltimore, MD Department of Critical Care Medicine, Cooper University Health System, Camden, NJ Pittsburgh Critical Care Associates, Pittsburgh, PA Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN Neuroscience Institute, The Queen's Medical Center, Honolulu, HI Department of Surgery, University of Florida, Gainesville, FL Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL Department of Medicine, Emory University, Atlanta, GA Department of Emergency Medicine, Washington University School of Medicine in Saint Louis, St. Louis, MO.

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http://dx.doi.org/10.1097/CCM.0000000000003691DOI Listing

Medicine and Intensive Care Training: The Search for the Holy Grail of Diversity Within Harmonization.

Crit Care Med 2019 May;47(5):e428-e429

INSERM, IAME, UMR 1137, Paris, France, and Univ Paris Diderot, Sorbonne Paris Cité, Paris, France, and AP-HP, Hôpital Louis Mourier, service de Médecine intensive Réanimation, Colombes, France Medical Intensive Care Unit and Department of Biostatistics, APHP, Hôpital St-Louis, Paris, France, and Univ Paris Diderot, Sorbonne Paris Cité, Paris, France Medical Intensive care unit, Grenoble University Hospital, Grenoble 1 University, U823, La Tronche, France Medical Intensive care unit, Grenoble University Hospital, Grenoble 1 University, U823, La Tronche, France, and INSERM, Université Grenoble-Alpes, U1042, HP2, 38000, Grenoble, France Sorbonne Université INSERM Unité Mixte de Recherche, Institute of Cardiometabolism and Nutrition, Paris, France, and AP-HP, Hôpital Pitié-Salpêtrière, Institut de Cardiologie, Service de Médecine Intensive-Réanimation, Paris, France Médecine Intensive Réanimation, CHRU de Tours, Tours, France.

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http://dx.doi.org/10.1097/CCM.0000000000003643DOI Listing
May 2019
1 Read

Detection of Intestinal Tissue Perfusion by Real-Time Breath Methane Analysis in Rat and Pig Models of Mesenteric Circulatory Distress.

Crit Care Med 2019 May;47(5):e403-e411

Institute of Surgical Research, Faculty of Medicine, University of Szeged, Szeged, Hungary.

Objectives: Methane (CH4) breath test is an established diagnostic method for gastrointestinal functional disorders. Our aim was to explore the possible link between splanchnic circulatory changes and exhaled CH4 in an attempt to recognize intestinal perfusion failure.

Design: Randomized, controlled in vivo animal study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003659DOI Listing
May 2019
1 Read

A Novel Approach for the Targeted Inhibition of Platelet Activation-Separating the Good From the Bad.

Crit Care Med 2019 May;47(5):741-743

Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1097/CCM.0000000000003705DOI Listing

Sepsis Epidemiology From Administrative Data: Going, Going….

Authors:
Steven Q Simpson

Crit Care Med 2019 May;47(5):739-740

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, KS.

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http://dx.doi.org/10.1097/CCM.0000000000003690DOI Listing

Integrating Advanced Practice Providers Into the Multiprofessional Critical Care Team.

Crit Care Med 2019 May;47(5):737-738

Emory Healthcare, Emory Critical Care Center, Atlanta, GA.

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http://dx.doi.org/10.1097/CCM.0000000000003704DOI Listing

What Is the Skinny on Obesity During Sepsis?

Crit Care Med 2019 May;47(5):735-736

Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH Division of Research, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH Department of Anesthesiology, Washington University School of Medicine, St Louis, MO.

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http://dx.doi.org/10.1097/CCM.0000000000003707DOI Listing

Saved From Sepsis: Can Immunotherapy Improve Acute and Postacute Outcomes?

Crit Care Med 2019 May;47(5):733-735

Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1097/CCM.0000000000003702DOI Listing

Where There Is No Law, There Is No Transgression: Goal-Directed Therapy for Traumatic Brain Injury.

Authors:
Matthew A Koenig

Crit Care Med 2019 May;47(5):731-733

The Queen's Medical Center, Neuroscience Institute, Honolulu, HI.

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http://dx.doi.org/10.1097/CCM.0000000000003703DOI Listing
May 2019
3 Reads

Presepsin As a Biomarker for Evaluating Prognosis and Early Innate Immune Response of Out-of-Hospital Cardiac Arrest Patients After Return of Spontaneous Circulation.

Crit Care Med 2019 Apr 5. Epub 2019 Apr 5.

All authors: Department of Emergency Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Objectives: After return of spontaneous circulation, patients who experienced out-of-hospital cardiac arrest present an impaired innate immune response that resembles sepsis. Presepsin, a new biomarker for sepsis, has not been studied in out-of-hospital cardiac arrest patients. This study explored the role of presepsin in evaluating the prognosis and early innate immune alteration of out-of-hospital cardiac arrest patients after return of spontaneous circulation by observing presepsin levels, CD14, and human leukocyte antigen-DR expression on monocytes. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003764DOI Listing
April 2019
5 Reads

The Clinical Spectrum of New-Onset Status Epilepticus.

Crit Care Med 2019 Apr 5. Epub 2019 Apr 5.

All authors: Department of Neurology, Mayo Clinic, Rochester, MN.

Objectives: There is a paucity of data on patients with new-onset status epilepticus in patients without a prior history of epilepsy; we aimed to describe clinical characteristics and assess variables predictive of outcomes.

Design: Retrospective cohort.

Setting: Quaternary academic medical center. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003776DOI Listing

Application of the New Centers for Disease Control and Prevention Surveillance Criteria for Ventilator-Associated Events to a Cohort of PICU Patients Identifies Different Patients Compared With the Previous Definition and Physician Diagnosis.

Crit Care Med 2019 Apr 5. Epub 2019 Apr 5.

Section of Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.

Objectives: We sought to compare the performance of the 2008 Centers for Disease Control and Prevention Pediatric criteria for ventilator-associated pneumonia, the 2013 Adult Ventilator-Associated Condition criteria, the new Draft Pediatric Ventilator-Associated Condition criteria, and physician-diagnosed ventilator-associated pneumonia in a cohort of PICU patients.

Design: Secondary analysis of a previously conducted prospective observational study.

Setting: PICU within a tertiary care children's hospital between April 1, 2010, and April 1, 2011. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003766DOI Listing
April 2019
1 Read

Sleep and Work in ICU Physicians During a Randomized Trial of Nighttime Intensivist Staffing.

Crit Care Med 2019 Apr 12. Epub 2019 Apr 12.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Objectives: To compare sleep, work hours, and behavioral alertness in faculty and fellows during a randomized trial of nighttime in-hospital intensivist staffing compared with a standard daytime intensivist model.

Design: Prospective observational study.

Setting: Medical ICU of a tertiary care academic medical center during a randomized controlled trial of in-hospital nighttime intensivist staffing. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003773DOI Listing
April 2019
3 Reads

The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS): A Randomized Pilot Study.

Crit Care Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Medicine, Division of Pulmonary Critical Care and Sleep, Alpert Medical School of Brown University, Providence, RI.

Objectives: It is unclear if a low- or high-volume IV fluid resuscitation strategy is better for patients with severe sepsis and septic shock.

Design: Prospective randomized controlled trial.

Setting: Two adult acute care hospitals within a single academic system. Read More

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http://Insights.ovid.com/crossref?an=00003246-900000000-9597
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http://dx.doi.org/10.1097/CCM.0000000000003779DOI Listing
April 2019
9 Reads

Novel Risk Factors for Posttraumatic Stress Disorder Symptoms in Family Members of Acute Respiratory Distress Syndrome Survivors.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA.

Objectives: Family members of ICU survivors report long-term psychologic symptoms of posttraumatic stress disorder. We describe patient- and family-member risk factors for posttraumatic stress disorder symptoms among family members of survivors of acute respiratory distress syndrome.

Design: Prospective cohort study of family members of acute respiratory distress syndrome survivors. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003774DOI Listing
April 2019
1 Read

Fluid Intake But Not Fluid Balance Is Associated With Poor Outcome in Nontraumatic Subarachnoid Hemorrhage Patients.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Neurological Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Objectives: Optimal fluid management is important in patients with acute brain injury, including subarachnoid hemorrhage. We aimed to examine the relationship between daily fluid intake and fluid balance with hospital complications and functional outcome.

Design: Retrospective observational cohort study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003775DOI Listing
April 2019
1 Read

Cost-Effectiveness Studies in the ICU: A Systematic Review.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Sinai Health System and the Department of Medicine, University of Toronto, Toronto, ON, Canada.

Objectives: Cost-effectiveness analyses are increasingly used to aid decisions about resource allocation in healthcare; this practice is slow to translate into critical care. We sought to identify and summarize original cost-effectiveness studies presenting cost per quality-adjusted life year, incremental cost-effectiveness ratios, or cost per life-year ratios for treatments used in ICUs.

Design: We conducted a systematic search of the English-language literature for cost-effectiveness analyses published from 1993 to 2018 in critical care. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003768DOI Listing
April 2019
2 Reads

Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial.

Crit Care Med 2019 Apr 8. Epub 2019 Apr 8.

Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Objectives: To examine long-term survival and quality of life of patients with early septic shock.

Design: Prospective, randomized, parallel-group trial.

Setting: Fifty-one hospitals in Australia, New Zealand, Finland, Hong Kong, and the Republic of Ireland. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003762DOI Listing
April 2019
1 Read

Staged Implementation of Awakening and Breathing, Coordination, Delirium Monitoring and Management, and Early Mobilization Bundle Improves Patient Outcomes and Reduces Hospital Costs.

Crit Care Med 2019 Apr 10. Epub 2019 Apr 10.

Division of Critical Care Medicine, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Objectives: To measure the impact of staged implementation of full versus partial ABCDE bundle on mechanical ventilation duration, ICU and hospital lengths of stay, and cost.

Design: Prospective cohort study.

Setting: Two medical ICUs within Montefiore Healthcare Center (Bronx, NY). Read More

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http://dx.doi.org/10.1097/CCM.0000000000003765DOI Listing
April 2019
5 Reads

Reducing Iatrogenic Pneumothoraces: Using Real-Time Ultrasound Guidance for Pleural Procedures.

Crit Care Med 2019 Apr 10. Epub 2019 Apr 10.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL.

Objectives: Awareness of the impact of bedside ultrasound to reduce iatrogenic pneumothoraces while performing bedside pleural procedures has increased but with little understanding in how ultrasound is used for these procedures.

Design And Setting: We conducted a retrospective chart review at a tertiary referral center in the United States from January 1, 2014, to March 31, 2017. Our study assessed adverse effect rates between real-time ultrasound-guided and ultrasound-marked thoracenteses and thoracostomy tube placements. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003761DOI Listing
April 2019
1 Read

Association Between Mean Arterial Pressure and Acute Kidney Injury and a Composite of Myocardial Injury and Mortality in Postoperative Critically Ill Patients: A Retrospective Cohort Analysis.

Crit Care Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH.

Objectives: Hypotension thresholds that provoke renal injury, myocardial injury, and mortality in critical care patients remain unknown. We primarily sought to determine the relationship between hypotension and a composite of myocardial injury (troponin T ≥ 0.03 ng/mL without nonischemic cause) and death up to 7 postoperative days. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003763DOI Listing
April 2019
1 Read

Body Composition and Acquired Functional Impairment in Survivors of Pediatric Critical Illness.

Crit Care Med 2019 Apr 4. Epub 2019 Apr 4.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Objectives: To identify whether body mass and composition is associated with acquired functional impairment in PICU survivors.

Design: Retrospective dual-cohort study.

Setting: Single multidisciplinary PICU. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003720DOI Listing
April 2019
1 Read

Socioeconomic Position and Health Outcomes Following Critical Illness: A Systematic Review.

Crit Care Med 2019 Mar 27. Epub 2019 Mar 27.

William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom.

Objectives: Systematically review evidence examining association between preadmission socioeconomic position and physical function, health-related quality of life and survival following critical illness.

Data Sources: Four electronic databases (MEDLINE, Embase, CINAHL, CENTRAL) and personal libraries were searched. Reference lists of eligible articles were cross-checked. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003727DOI Listing

Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials.

Crit Care Med 2019 Mar 27. Epub 2019 Mar 27.

Division of Critical Care, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.

Objectives: It is unknown whether more frequent screening of invasively ventilated patients, identifies patients earlier for a spontaneous breathing trial, and shortens the duration of ventilation. We assessed the feasibility of conducting a large trial to evaluate screening frequency in critically ill adults in the North American context.

Design: We conducted two contemporaneous, multicenter, pilot, randomized controlled trials (the LibeRation from MEchanicaL VEntilAtion and ScrEening Frequency [RELEASE] and Screening Elderly PatieNts For InclusiOn in a Weaning [SENIOR] trials) to address concerns regarding the potential for higher enrollment, fewer adverse events, and better outcomes in younger patients. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003722DOI Listing
March 2019
2 Reads

Morphine Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

Crit Care Med 2019 Mar 27. Epub 2019 Mar 27.

Metrum Research Group, Tariffville, CT.

Objective: To develop a pharmacokinetic-pharmacogenomic population model of morphine in critically ill children with acute respiratory failure.

Design: Prospective pharmacokinetic-pharmacogenomic observational study.

Setting: Thirteen PICUs across the United States. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003741DOI Listing
March 2019
1 Read

Thromboelastography Predicts Thromboembolism in Critically Ill Coagulopathic Patients.

Crit Care Med 2019 Mar 27. Epub 2019 Mar 27.

Department of Intensive Care Medicine, Royal Perth Hospital, Perth, WA, Australia.

Objectives: Critically ill patients with deranged conventional coagulation tests are often perceived to have an increased bleeding risk. Whether anticoagulant prophylaxis for these patients should be withheld is contentious. This study assessed the ability of using in vitro clot strength, as measured by thromboelastography, to predict thromboembolism in patients with abnormal coagulation profiles. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003730DOI Listing
March 2019
1 Read

Linking Big Data and Prediction Strategies: Tools, Pitfalls, and Lessons Learned.

Crit Care Med 2019 Mar 27. Epub 2019 Mar 27.

Shock Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD.

Objectives: Modern critical care amasses unprecedented amounts of clinical data-so called "big data"-on a minute-by-minute basis. Innovative processing of these data has the potential to revolutionize clinical prognostics and decision support in the care of the critically ill but also forces clinicians to depend on new and complex tools of which they may have limited understanding and over which they have little control. This concise review aims to provide bedside clinicians with ways to think about common methods being used to extract information from clinical big datasets and to judge the quality and utility of that information. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003739DOI Listing

Respiratory Mechanics, Lung Recruitability, and Gas Exchange in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome.

Crit Care Med 2019 Mar 22. Epub 2019 Mar 22.

Department of Anesthesia and Intensive Care, ASST Santi Paolo e Carlo, San Paolo University Hospital, Milan, Italy.

Objectives: Acute respiratory distress syndrome is a clinical syndrome characterized by a refractory hypoxemia due to an inflammatory and high permeability pulmonary edema secondary to direct or indirect lung insult (pulmonary and extrapulmonary form). Aim of this study was to evaluate in a large database of acute respiratory distress syndrome patients, the pulmonary versus extrapulmonary form in terms of respiratory mechanics, lung recruitment, gas exchange, and positive end-expiratory pressure response.

Design: A secondary analysis of previously published data. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003715DOI Listing
March 2019
2 Reads

Vagus Nerve Stimulation Attenuates Multiple Organ Dysfunction in Resuscitated Porcine Progressive Sepsis.

Crit Care Med 2019 Mar 25. Epub 2019 Mar 25.

Department of Physiology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.

Objectives: To investigate the potential benefits of vagus nerve stimulation in a clinically-relevant large animal model of progressive sepsis.

Design: Prospective, controlled, randomized trial.

Setting: University animal research laboratory. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003714DOI Listing
March 2019
1 Read

Acute Kidney Injury in Critically Ill Patients After Noncardiac Major Surgery: Early Versus Late Onset.

Crit Care Med 2019 Mar 20. Epub 2019 Mar 20.

Center for Critical Care Nephrology, CRISMA, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.

Objectives: Acute kidney injury is a common complication of major surgery. However, acute kidney injury occurring within the first 48 hours after surgery (early acute kidney injury) and therefore likely related to the surgery itself is possibly different from acute kidney injury occurring after 48 hours (late acute kidney injury). The aim of this study was to describe the epidemiology and identify differences in risk factors and outcomes between early and late acute kidney injury following major surgery. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003710DOI Listing
March 2019
4 Reads

Patient and Family Engagement During Treatment Decisions in an ICU: A Discourse Analysis of the Electronic Health Record.

Crit Care Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Surgery, University of Wisconsin, Madison, WI.

Objectives: Shared decision-making is recommended for critically ill adults who face major, preference-sensitive treatment decisions. Yet, little is known about when and how patients and families are engaged in treatment decision-making over the longitudinal course of a critical illness. We sought to characterize patterns of treatment decision-making by evaluating clinician discourse in the electronic health record of critically ill adults who develop chronic critical illness or die in an ICU. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003711DOI Listing

Cardiac Arrest and Subsequent Hospitalization-Induced Posttraumatic Stress Is Associated With 1-Year Risk of Major Adverse Cardiovascular Events and All-Cause Mortality.

Crit Care Med 2019 Mar 18. Epub 2019 Mar 18.

Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University Medical Center, New York, NY.

Objectives: To compare 1-year all-cause mortality and major adverse cardiovascular events in cardiac arrest survivors with and without posttraumatic stress disorder symptomatology at hospital discharge.

Design: Prospective, observational cohort.

Setting: ICUs at a tertiary-care center. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003713DOI Listing
March 2019
2 Reads

Prognostic Value of Glial Fibrillary Acidic Protein in Patients With Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.

Crit Care Med 2019 Mar 19. Epub 2019 Mar 19.

CHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit (Trauma - Emergency - Critical Care Medicine), Université Laval, Québec City, QC, Canada.

Objectives: Biomarkers have been suggested as potential prognostic predictors following a moderate or severe traumatic brain injury but their prognostic accuracy is still uncertain. The objective of this systematic review is to assess the ability of the glial fibrillary acidic protein to predict prognosis in patients with moderate or severe traumatic brain injury.

Data Sources: MEDLINE, Embase, CENTRAL, and BIOSIS electronic databases and conference abstracts, bibliographies of selected studies, and narrative reviews were searched. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003728DOI Listing

Outcomes of Cancer Patients Discharged From ICU After a Decision to Forgo Life-Sustaining Therapies.

Crit Care Med 2019 Mar 19. Epub 2019 Mar 19.

Intensive Care Unit, AC Camargo Cancer Center, São Paulo, Brazil.

Objectives: Many cancer patients are admitted to an ICU and decisions to forgo life-sustaining therapies are frequent during ICU stay. A significant proportion of these patients are subsequently discharged from ICU, but their outcomes are unknown.

Design: Retrospective. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003729DOI Listing
March 2019
3 Reads

Trigeminal Nerve Stimulation: A Novel Method of Resuscitation for Hemorrhagic Shock.

Crit Care Med 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.

Objectives: To determine if trigeminal nerve stimulation can ameliorate the consequences of acute blood loss and improve survival after severe hemorrhagic shock.

Design: Animal study.

Setting: University research laboratory. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003735DOI Listing
March 2019
4 Reads

Health Insurance and Out-of-Pocket Costs in the Last Year of Life Among Decedents Utilizing the ICU.

Crit Care Med 2019 Mar 19. Epub 2019 Mar 19.

Department of Medical Ethics and Health Policy, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA.

Objectives: Use of intensive care is increasing in the United States and may be associated with high financial burden on patients and their families near the end of life. Our objective was to estimate out-of-pocket costs in the last year of life for individuals who required intensive care in the months prior to death and examine how these costs vary by insurance coverage.

Design: Observational cohort study using seven waves of post-death interview data (2002-2014). Read More

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http://dx.doi.org/10.1097/CCM.0000000000003723DOI Listing
March 2019
7 Reads

Original Intracerebral Hemorrhage Score for the Prediction of Short-Term Mortality in Cerebral Hemorrhage: Systematic Review and Meta-Analysis.

Crit Care Med 2019 Mar 19. Epub 2019 Mar 19.

Centre for Health Technology and Services Research (CINTESIS) & Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto: Alameda Prof. Hernani Monteiro, Porto, Portugal.

Objectives: To systematically assess the discrimination and calibration of the Intracerebral Hemorrhage score for prediction of short-term mortality in intracerebral hemorrhage patients and to study its determinants using heterogeneity analysis.

Data Sources: PubMed, ISI Web of Knowledge, Scopus, and CENTRAL from inception to September 15, 2018.

Study Selection: Adult studies validating the Intracerebral Hemorrhage score for mortality prediction in nontraumatic intracerebral hemorrhage at 1 month/discharge or sooner. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003744DOI Listing
March 2019
6.312 Impact Factor

Center Effects in Hospital Mortality of Critically Ill Patients With Hematologic Malignancies.

Crit Care Med 2019 Mar 19. Epub 2019 Mar 19.

Service de Biostatistique et Information Médicale, AP-HP Hôpital Saint Louis, Paris, France.

Objectives: We aimed to investigate center effects on hospital mortality of ICU patients with hematologic malignancies and to explore interactions between center and patients characteristics.

Design: Multicenter prospective cohort.

Setting: Seventeen ICUs across France and Belgium. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003717DOI Listing
March 2019
3 Reads

Reporting of Organ Support Outcomes in Septic Shock Randomized Controlled Trials: A Methodologic Review-The Sepsis Organ Support Study.

Crit Care Med 2019 Mar 19. Epub 2019 Mar 19.

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, département Biostatistique, Santé publique, Information Medicale, F75013, Paris, France.

Objectives: Many recent randomized controlled trials in the field of septic shock failed to demonstrate a benefit on mortality. Randomized controlled trials increasingly report organ support duration and organ support-free days as primary or secondary outcomes. We conducted a methodologic systematic review to assess how organ support outcomes were defined and reported in septic shock randomized controlled trials. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003746DOI Listing
March 2019
4 Reads