791,389 results match your criteria Critical care London England[Journal]


The Impact of Continuous Positive Airway Pressure upon Pleural Fluid Pressures during Thoracentesis.

Respiration 2019 Apr 17:1-5. Epub 2019 Apr 17.

University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.

Background: Excessive drop of pleural pressure (Ppl) during therapeutic thoracentesis may be related to adverse events and/or to repeated procedures due to incomplete drainage.

Objective: This was a pilot study of the impact of the application of continuous positive airway pressure (CPAP) at +5 cm H2O upon the Ppl profile during thoracentesis.

Methods: This was a prospective, controlled study of 49 consecutive adults who underwent thoracentesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496610DOI Listing
April 2019
1 Read

Development and Validation of Molecular Assays for Limited Tissue Samples.

Acta Cytol 2019 Apr 17:1-8. Epub 2019 Apr 17.

Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA,

As the value of molecular testing of cancer specimens increases, the number of tests imposed on tumor specimens also increases, often in tension with the amount of tumor material available. To develop and validate molecular assays for limited specimens, there are specific concerns that must be addressed, including DNA quality, quantity, and abundance; the number of targets/ability to multiplex; and the analytical sensitivity and specificity of the assay itself. Ultimately, weighing these considerations during assay validation in the overall context of clinical utility and laboratory workflow is critical for delivering the highest level of personalized care to patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499109DOI Listing

The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia.

Dev Neurosci 2019 Apr 17:1-14. Epub 2019 Apr 17.

Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.

Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496467DOI Listing

Dynamic properties of asymmetric double Josephson junction stack with quasiparticle imbalance.

Nanotechnology 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nuclear Physics, M V Lomonosov Moscow State University, 1/2 Leninskie Gory, Moscow 119992, RUSSIA,, Moscow, 119991, RUSSIAN FEDERATION.

We study analytically and numerically the influence of the quasiparticle charge imbalance on the dynamics of the asymmetric Josephson stack formed by two inequivalent junctions: the fast capacitive junction JJ1 and slow non-capacitive junction JJ2. We find, that the switching of the fast junction into resistive state leads to significant increase of the effective critical current of the slow junction. At the same time, the initial switching of the slow junction may either increase or decrease the effective critical current of the fast junction, depending on ratio of their resistances and the value of the capacitance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/ab1a8eDOI Listing

Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Radiology, University of Chicago Medical Center, Chicago, Illinois, UNITED STATES.

Focused ultrasound therapies are a noninvasive means to ablate tissue. Histotripsy utilizes short ultrasound pulses with sufficient tension to nucleate bubble clouds that impart lethal strain to the surrounding tissues. Tracking bubble cloud dissolution between the application of histotripsy pulses is critical to ensure treatment efficacy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6560/ab1a64DOI Listing

Shear-induced alignment of collagen fibrils using 3D cell printing for corneal stroma tissue engineering.

Biofabrication 2019 Apr 17. Epub 2019 Apr 17.

Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Kyungbuk 790-784, KOREA, Pohang, KOREA, REPUBLIC OF.

The microenvironments of tissues or organs are complex architectures comprised of structural proteins including collagen. Particularly, the cornea is organized in a lattice pattern of collagen fibrils which play a significant role in its transparency. This paper introduces a transparent bioengineered corneal structure for transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1758-5090/ab1a8bDOI Listing

Elastic properties and intrinsic strength of two-dimensional InSe flakes.

Nanotechnology 2019 Apr 17. Epub 2019 Apr 17.

University of Washington, Seattle, Washington, UNITED STATES.

Mechanical property of two-dimensional (2D) materials is critical for their applications in functional devices as well as for strain engineering. Here, we report the Young's modulus and breaking strength of multilayered InSe, an emerging 2D semiconductors of layered group III chalcogenide. Few-layer InSe flaks were exfoliated from bulk InSe crystal onto Si/SiO2 substrate with micro-fabricated holes, and indentation tests were carried using an Atomic Force Microscopy (AFM) probe. Read More

View Article

Download full-text PDF

Source
http://iopscience.iop.org/article/10.1088/1361-6528/ab1a96
Publisher Site
http://dx.doi.org/10.1088/1361-6528/ab1a96DOI Listing
April 2019
1 Read

Strain-stress relationship and dislocation evolution of W-Cu bilayers from a constructed n-body W-Cu potential.

J Phys Condens Matter 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan, CHINA.

An n-body W-Cu potential is constructed under the framework of the embedded-atom method by means of a proposed function of the cross potential. This W-Cu potential is realistic to reproduce mechanical property and structural stability of WCu solid solutions within the entire composition range, and has better performances than the three W-Cu potentials already published in the literature. Based on this W-Cu potential, molecular dynamics simulation is conducted to reveal the mechanical property and dislocation evolution of the bilayer structure between pure W and W0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-648X/ab1a8aDOI Listing

Inhibition of MRP4 alleviates sepsis-induced acute lung injury in rats.

Int Immunopharmacol 2019 Apr 14;72:211-217. Epub 2019 Apr 14.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China. Electronic address:

This study was undertaken to examine the regulatory role of multidrug resistance-associated protein 4 (MRP4) in an experimental model of sepsis-induced acute lung injury in rats. Sepsis was induced by cecal ligation and puncture in anesthetized rats. Animals were then randomly assigned to receive intravenous injection of vehicle or MRP4 inhibitor (MK571, 20 mg/kg). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.04.009DOI Listing

Host bacterial community of MGEs determines the risk of horizontal gene transfer during composting of different animal manures.

Environ Pollut 2019 Apr 8;250:166-174. Epub 2019 Apr 8.

Key Laboratory of Agricultural Microbiology of Heilongjiang Province Science and Technology Department, Northeast Agricultural University, Harbin, 150030, China; College of Life Science, Northeast Agricultural University, Harbin, 150030, China. Electronic address:

Mobile genetic elements (MGEs) play critical roles in transferring antibiotic resistance genes (ARGs) among different microorganisms in the environment. This study aimed to explore the fate of MGEs during chicken manure (CM) and bovine manure (BM) composting to assess horizontal transfer risks of ARGs. The results showed that the removal efficiency of MGEs during CM composting was significantly higher than that during BM composting, because the potential host bacteria of MGEs were eliminated largely during CM composting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2019.04.037DOI Listing

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review.

Eur J Med Chem 2019 Apr 10;173:117-153. Epub 2019 Apr 10.

School of Chemistry, Chemical Engineering and Life Science, School of Materials Science and Engineering, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China. Electronic address:

At present more than 250 FDA approved chlorine containing drugs were available in the market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is quite obvious to expect that in coming decades there will be an even greater number of new chlorine-containing pharmaceuticals in market. Chlorinated compounds represent the family of compounds promising for use in medicinal chemistry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.03.063DOI Listing

Comparison of circular and sagittal reinforced rod options on the sagittal balance restoration in adolescents undergoing pedicle screw instrumentation for idiopathic scoliosis.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Paediatric Orthopaedic Surgery, University of Turku, Turku University Hospital, Kiinamyllynkatu 4-8, FI-20521 Turku.

Objective: Pedicle screw instrumentation is widely used for spinal deformity correction and fusion in adolescents for idiopathic scoliosis. The goal is to achieve and sustain good alignment in all three plains. We compared two different cobalt-chromium (CoCr) rod designs with different stiffness, in regard to the coronal and sagittal balance restoration in adolescents operated for idiopathic scoliosis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750193102
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2019.04.028DOI Listing
April 2019
1 Read

Role of VE-Cadherin and p120-catenin in the formation of experimental intracranial aneurysms in animals.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330000, China P.R. Electronic address:

Background: Dysfunction of endothelial cells (ECs) constitutes a critical factor in formatting intracranial aneurysms (IAs). However, little is known about the response of ECs to hemodynamic insults and its contribution to IA formation.

Methods And Material: IAs models were constructed in both adult female New Zealand white rabbits and male Sprague-Dawley rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.04.077DOI Listing

Evoked potentials improve multimodal prognostication after cardiac arrest.

Resuscitation 2019 Apr 14. Epub 2019 Apr 14.

Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

Aim: Predicting recovery in comatose post-cardiac arrest patients requires multiple modalities of prognostic assessment. In isolation, absent N20 cortical responses in somatosensory evoked potentials (SSEPs) are a specific predictor of poor outcome. It is unknown whether SSEP results, when assessed in the context of prior knowledge (demographic and clinical information), change the pretest predicted probability of recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.resuscitation.2019.04.011DOI Listing

Reactive oxygen species as mediators of oxygen signaling during fetal-to-neonatal circulatory transition.

Free Radic Biol Med 2019 Apr 14. Epub 2019 Apr 14.

Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.

Reactive oxygen species (ROS) are frequently seen as pathological agents of oxidative stress. However, ROS are not always deleterious and can also act as cell signaling molecules. Vascular oxygen sensing and signaling during fetal-to-neonatal circulatory transition is a remarkable example of the physiological regulatory actions of ROS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.008DOI Listing

The Cytokines of Asthma.

Immunity 2019 Apr;50(4):975-991

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, USA.

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. "Type 2-low" asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2019.03.018DOI Listing

The Immunobiology of the Interleukin-12 Family: Room for Discovery.

Immunity 2019 Apr;50(4):851-870

Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 West Markham St., Little Rock, AR 72205, USA. Electronic address:

The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family members utilize shared receptors and cytokine subunits and influence the outcome of cancer, infection, and inflammatory diseases. Consequently, many facets of their biology are being therapeutically targeted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2019.03.011DOI Listing
April 2019
3 Reads

Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse.

Cell Rep 2019 Apr;27(3):900-915.e5

Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA. Electronic address:

In the mouse retina, more than 30 retinal ganglion cell (RGC) subtypes have been classified based on a combined metric of morphological and functional characteristics. RGCs arise from a common pool of retinal progenitor cells during embryonic stages and differentiate into mature subtypes in adult retinas. However, the cellular and molecular mechanisms controlling formation and maturation of such remarkable cellular diversity remain unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.077DOI Listing

Restoring retinal neurovascular health via substance P.

Exp Cell Res 2019 Apr 14. Epub 2019 Apr 14.

Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol, UK; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK. Electronic address:

Regulation of vascular permeability plays a major role in the pathophysiology of visually threatening conditions such as retinal vein occlusion and diabetic retinopathy. Principally, several factors such as vascular endothelial growth factor (VEGF), are up-regulated or induced in response to hypoxia thus adversely affecting the blood-retinal barrier (BRB), resulting in retinal edema and neovascularisation. Furthermore, current evidence supports a dysregulation of the inner retinal neural-vascular integrity as a critical factor driving retinal ganglion cell (RGC) death and visual loss. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144827193015
Publisher Site
http://dx.doi.org/10.1016/j.yexcr.2019.04.008DOI Listing
April 2019
1 Read

Deletion of maternal UHRF1 severely reduces mouse oocyte quality and causes developmental defects in preimplantation embryos.

FASEB J 2019 Apr 17:fj201801696RRRR. Epub 2019 Apr 17.

Department of Histology and Embryology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.

The ubiquitin-like, containing PHD and RING finger domains, 1 (UHRF1) protein recognizes DNA methylation and histone modification and plays a critical role in epigenetic regulation. Recently, UHRF1 was shown to have a role in DNA methylation in oocytes and early embryos. Here, we reveal that maternal UHRF1 determines the quality of mouse oocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201801696RRRRDOI Listing

Opioid Tolerance in Critical Illness. Reply.

N Engl J Med 2019 Apr;380(16)

Massachusetts General Hospital, Boston, MA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1902646DOI Listing

Opioid Tolerance in Critical Illness.

N Engl J Med 2019 Apr;380(16)

Hope Hospice and Palliative Care, Providence, RI.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1902646DOI Listing

Responding to Evolving Abortion Regulations - The Critical Role of Primary Care.

N Engl J Med 2019 Apr 17. Epub 2019 Apr 17.

From the Division of General Internal Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, and the University of California, San Francisco - both in San Francisco.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMp1903572DOI Listing

Generation of ERK-independent Human and Non-Human Primate Pluripotent Stem Cells.

Curr Protoc Stem Cell Biol 2019 Apr 17:e85. Epub 2019 Apr 17.

Yale University School of Medicine, New Haven, Connecticut.

The production of human organs inside human-animal interspecies chimeras might one day comprise a viable strategy for generating patient-specific organs, but such experiments will require human chimera-competent pluripotent stem (PS) cells. The stabilization of PS cell self-renewal in serum-free medium and ERK blockade might be critical for capturing primate chimera-competent pluripotency. It has recently been shown that shielding primate cells from the activation of ERK, WNT, and PKC signaling is crucial for deriving African green monkey ERK-independent PS cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpsc.85DOI Listing

Loss of the vitamin D receptor in human breast cancer cells promotes epithelial to mesenchymal cell transition and skeletal colonisation.

J Bone Miner Res 2019 Apr 17. Epub 2019 Apr 17.

Bone Research Program, ANZAC Research Institute and Concord Medical School, The University of Sydney, Sydney, Australia.

Expression of the vitamin D receptor (VDR) is thought to be associated with neoplastic progression. However, the role of the VDR in breast cancer metastasis to bone, and the molecular mechanisms underlying this process are unknown. Employing a rodent model (female Balb/c nu/nu mice) of systemic metastasis, we here demonstrate that knock-down of the VDR strongly increases the metastatic potential of MDA-MB-231 human breast cancer cells to bone, resulting in significantly greater skeletal tumour burden. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.3744DOI Listing

Combined Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation to Model Inflammatory Lung Disease in Rheumatoid Arthritis.

J Bone Miner Res 2019 Apr 17. Epub 2019 Apr 17.

Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE.

Objectives: Rheumatoid Arthritis (RA) is characterized by extra-articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. The collagen-induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone/joint-lung inflammatory outcomes.

Methods: DBA/1J mice were intranasally treated with saline or ODE daily for 5 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.3745DOI Listing

Early results of a modified biological valved conduit for the Bentall procedure.

J Card Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Division of Cardiac Surgery, The McGill University Health Center, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

Introduction: Few bioprosthetic valved conduits for aortic root surgery are commercially available. Long-term Warfarin therapy (mechanical), potential root calcification (xeno- or homograft valves), and the need for additional ascending aorta grafts are concerns associated with currently used valved conduits. A simplified, self-assembled bioroot conduit comprising currently available materials that facilitates future intervention and exhibits advantages of a bioprosthesis was used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocs.14046DOI Listing

Calcium-Activated Chloride Channels in Newly Differentiating Mouse Lens Fiber Cells and Their Role in Volume Regulation.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1621-1629

Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, Chicago, Illinois, United States.

Purpose: Chloride channels have been proposed to play an important role in the regulation of lens volume. Unfortunately, little information is available about the molecular identity of these channels or how they are regulated in the lens due to the difficulties in isolating mouse fiber cells. Recently, our laboratory has developed a new technique for isolating these cells by using transgenic mouse lenses that lack both Cx50 and Cx46. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.19-26626DOI Listing

Early prediction of neurological outcome after barbiturate coma therapy in patients undergoing brain tumor surgery.

PLoS One 2019 17;14(4):e0215280. Epub 2019 Apr 17.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

After a difficult brain tumor surgery, refractory intracranial hypertension (RICH) may occur due to residual tumor or post-operative complications such as hemorrhage, infarction, and aggravated brain edema. We investigated which predictors are associated with prognosis when using barbiturate coma therapy (BCT) as a second-tier therapy to control RICH after brain tumor surgery. The study included adult patients who underwent BCT after brain tumor surgery between January 2010 and December 2016. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215280PLOS
April 2019
1 Read

Estimating the value of tropical coastal wetland habitats to fisheries: Caveats and assumptions.

PLoS One 2019 17;14(4):e0215350. Epub 2019 Apr 17.

College of Science and Engineering, James Cook University, Townsville, Queensland, Australia.

Habitat valuation can provide an objective basis for the prioritisation of conservation and restoration actions. The attribution of fisheries production to particular habitat units is an important measure of value, but is difficult to estimate. Using the case study of habitat use by juvenile banana prawns in a tropical estuary, we assessed the potential to produce valid value estimates at two spatio-conceptual scales: estuary reach and whole estuary. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215350PLOS

Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells.

PLoS One 2019 17;14(4):e0204387. Epub 2019 Apr 17.

Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Health Science Campus, Toledo, OH, United States of America.

Recent high-throughput-sequencing of cancer genomes has identified oncogenic mutations in the B-Raf genetic locus as one of the critical events in melanomagenesis. B-Raf encodes a serine/threonine kinase that regulates the MAPK/ERK kinase (MEK) and extracellular signal-regulated kinase (ERK) protein kinase cascade. In normal cells, the activity of B-Raf is tightly regulated and is required for cell growth and survival. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204387PLOS

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting.

PLoS One 2019 17;14(4):e0215163. Epub 2019 Apr 17.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

The vaccine elicitation of broadly neutralizing responses is a central goal of HIV research. Recently, we elicited cross-clade neutralizing responses against the N terminus of the fusion peptide (FP), a critical component of the HIV-entry machinery. While the consistency of the elicited cross-clade neutralizing responses was good in mice, it was poor in guinea pigs: after seven immunizations comprising either envelope (Env) trimer or FP coupled to a carrier, serum from only one of five animals could neutralize a majority of a cross-clade panel of 19 wild-type strains. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215163PLOS

Consensus Recommendations for the Conduct, Training, Implementation, and Research of Perioperative Handoffs.

Anesth Analg 2019 May;128(5):e71-e78

Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas Department of Anesthesiology, Cooper Medical School of Rowan University, Camden, New Jersey Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical School, Dallas, Texas Department of Anesthesiology, Vanderbilt Medical Center, Nashville, Tennessee Department of Anesthesiology, Duke University & Veterans Affairs Medical Center, Durham, North Carolina Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical School, Dallas, Texas Department of Anesthesiology, NorthShore University HealthSystem, Dallas, Texas, Department of Anesthesiology and Critical Care, University of Chicago, Chicago, Illinois Department of Anesthesiology, Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, Tennessee Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical School, Dallas, Texas Department of Anesthesiology, Cooper Medical School of Rowan University, Camden, New Jersey Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0000000000004118DOI Listing

Prevalence and determinants of poor quality of sleep among adolescents in rural Puducherry, South India.

Int J Adolesc Med Health 2019 Apr 17. Epub 2019 Apr 17.

Department of Preventive and Social Medicine, Jawaharlal Institute of Post Graduate Medical Education, Pondicherry, India.

Background Adolescence is a critical stage of life which is characterized by rapid biological, social and emotional development. India has the highest adolescent population, however, there is paucity of literature reporting the sleep quality among adolescents. Objective To determine the sleep quality and its associated factors among adolescents residing in selected villages of rural Puducherry. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/ijamh.ahead-of-print/ijamh-2
Publisher Site
http://dx.doi.org/10.1515/ijamh-2018-0101DOI Listing
April 2019
1 Read

LIMPRINT: A Sociological Perspective on "Chronic Edema".

Lymphat Res Biol 2019 Apr;17(2):168-172

5 School of Social Sciences, Nottingham Trent University, Nottingham, United Kingdom.

Chronic edema is a condition that is biologically complex, distressing for patients and sociopolitically weak. Like many other complex and chronic conditions, it has a low status within health care. The result is that it has a low priority in health policy and consequently is undervalued and undertreated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/lrb.2018.0082DOI Listing

A Study Using Visual Art Methods to Explore the Perceptions and Barriers of Self-Management in Children and Adolescents with Lymphedema.

Lymphat Res Biol 2019 Apr;17(2):231-244

2 Department of Vascular Medicine, EA2992, CHU Saint Eloi, University of Montpellier, Montpellier, France.

The aims of this study were to explore, using visual art methodology, how children and adolescents perceive their lymphedema and conceptualize the barriers and enablers in self-management and to explore the role of an educational camp in promoting self-efficacy. Participants (speaking English, French, and Italian) were recruited during an educational camp for children with lymphedema. Children and adolescents used different methodologies to depict living and self-managing their condition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/lrb.2018.0075DOI Listing

A review on screening tests for vestibular disorders.

Authors:
Helen S Cohen

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Bobby R Alford Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, United States.

Although many studies have reported on tests of the vestibular system a valid and reliable, evidence-based screening battery for easy clinical use remains elusive. Many screening tests attempt to assess the vestibulo-ocular reflex. Therefore, head shaking, the Dix-Hallpike maneuver, the supine roll test and head impulse tests are discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00819.2018DOI Listing

Quantitative proteomic analysis of a genetically induced prostate inflammation mouse model via custom 4-plex DiLeu isobaric labeling.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Urology, Carbone Cancer Center, George M. O'Brien Center of Benign Urology, University of Wisconsin Madison, United States.

Inflammation is involved in many prostate pathologies including infection, benign prostatic hyperplasia (BPH), and prostate cancer (CaP). Preclinical models are critical to our understanding of disease mechanisms, yet few models are genetically tractable. Here we present a comparative quantitative proteomic analysis of urine from mice with and without prostate-specific inflammation induced by conditional prostate epithelial interleukin-1 beta (IL-1 beta) expression. Read More

View Article

Download full-text PDF

Source
https://www.physiology.org/doi/10.1152/ajprenal.00387.2018
Publisher Site
http://dx.doi.org/10.1152/ajprenal.00387.2018DOI Listing
April 2019
1 Read

Changes in the power-duration relationship following prolonged exercise: estimation using conventional and all-out protocols and relationship to muscle glycogen.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 17. Epub 2019 Apr 17.

Sport and Health Sciences, Exeter University, United Kingdom.

It is not clear how the parameters of the power-duration relationship (critical power (CP) and W') are influenced by the performance of prolonged endurance exercise. We used severe-intensity prediction trials (conventional protocol) and the 3-min all-out test (3MT) to measure CP and W' following 2 h of heavy-intensity cycling exercise and took muscle biopsies to investigate possible relationships with changes in muscle glycogen concentration ([glycogen]). Fourteen participants completed a rested 3MT to establish end-test power (Control-EP) and work done above EP (Control-WEP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00031.2019DOI Listing

Transcriptomic responses to Ivacaftor and prediction of Ivacaftor clinical responsiveness.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Pittsburgh, Medicine, Pittsburgh, Pennsylvania, United States ;

Ivacaftor is a recently FDA-approved drug for the treatment of cystic fibrosis (CF) patients with at least one copy of the G511D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The transcriptomic effect of Ivacaftor in CF patients remains unclear. We aim to examine if and how the transcriptome of patients is influenced by Ivacaftor treatment and to determine if these data allow prediction of Ivacaftor responsiveness. Read More

View Article

Download full-text PDF

Source
https://www.atsjournals.org/doi/10.1165/rcmb.2019-0032OC
Publisher Site
http://dx.doi.org/10.1165/rcmb.2019-0032OCDOI Listing
April 2019
1 Read

Asymmetric Ductal Ectasia: An Often Overlooked Sign of Malignancy.

AJR Am J Roentgenol 2019 Apr 17:1-9. Epub 2019 Apr 17.

1 Department of Radiology, University of Cincinnati Medical Center, 234 Goodman St, Mail Location 0772, Cincinnati, OH 45219-2316.

The objective of this article is to define the clinical significance of asymmetric ductal ectasia by a review of literature and to describe the imaging findings. Asymmetric ductal ectasia has a significant risk for malignancy and high-risk lesions. The findings on conventional imaging may be subtle and easily overlooked. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2214/AJR.18.20651DOI Listing

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Groningen, University Medical Center Groningen, Pathology and Medical Biology, Groningen, Netherlands.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease. Read More

View Article

Download full-text PDF

Source
https://www.atsjournals.org/doi/10.1165/rcmb.2018-0416TR
Publisher Site
http://dx.doi.org/10.1165/rcmb.2018-0416TRDOI Listing
April 2019
1 Read

Anterior Cruciate Ligament Tear Promotes Skeletal Muscle Myostatin Expression, Fibrogenic Cell Expansion, and a Decline in Muscle Quality.

Am J Sports Med 2019 Apr 17:363546519832864. Epub 2019 Apr 17.

Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, USA.

Background: Anterior cruciate ligament (ACL) tears result in significant quadriceps muscle atrophy that is resistant to recovery despite extensive rehabilitation. Recent work suggests an elevated fibrotic burden in the quadriceps muscle after the injury, which may limit recovery. Elucidating the mechanisms and cell types involved in the progression of fibrosis is critical for developing new treatment strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0363546519832864DOI Listing

Maternal heavy metal exposure, thyroid hormones, and birth outcomes: a prospective cohort study.

J Clin Endocrinol Metab 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, China.

Context: Maternal thyroid hormones during pregnancy play a critical role in fetal development. However, whether maternal heavy metal exposure affects their thyroid hormones and the effects on fetal growth are still unclear.

Objective: To explore the impact of heavy metal exposure on maternal thyroid hormones and the potential mediation role of thyroid hormones on birth outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02492DOI Listing

Apparent interference with extracorporeal membrane oxygenation by liposomal amphotericin B in a patient with disseminated blastomycosis receiving continuous renal replacement therapy.

Am J Health Syst Pharm 2019 Apr 17. Epub 2019 Apr 17.

Drake University College of Pharmacy and Health Sciences, Des Moines, IA.

Purpose: We describe the use of liposomal amphotericin B and amphotericin B deoxycholate in a critically ill patient with pulmonary blastomycosis receiving both venovenous extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT).

Summary: A 50-year-old African American man presented for dyspnea and cough and was noted to have blastomycosis on bronchoscopy. He developed respiratory failure and acute kidney injury, requiring mechanical ventilation, ECMO, and CRRT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajhp/zxz054DOI Listing

Endometriosis.

Endocr Rev 2019 Apr 17. Epub 2019 Apr 17.

Departments of Obstetrics and Gynecology, Northwestern University, Chicago, IL.

Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/er.2018-00242DOI Listing

PEPred-Suite: improved and robust prediction of therapeutic peptides using adaptive feature representation learning.

Bioinformatics 2019 Apr 17. Epub 2019 Apr 17.

School of Computer Science and Technology, Tianjin University, Tianjin, China.

Motivation: Prediction of therapeutic peptides is critical for the discovery of novel and efficient peptide-based therapeutics. Computational methods, especially machine learning based methods, have been developed for addressing this need. However, most of existing methods are peptide-specific; currently, there is no generic predictor for multiple peptide types. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btz246DOI Listing

Critical analysis of the classic indications for myocardial revascularization.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):319-325. Epub 2019 Apr 11.

Department of Atherosclerosis, Heart Institute of the Hospital das Clínicas of the Faculty of Medicine of USP (InCor-HCFMUSP), São Paulo, Brasil.

Treatment of stable coronary artery disease (CAD) relies on improved prognosis and relief of symptoms. National and international guidelines on CAD support the indication of revascularization in patients with limiting symptoms and refractory to optimal medical treatment, as well as in clinical situations where there is a prognostic benefit of interventional treatment. Most of the studies that support the guidelines for indication of revascularization date back to the 1980s and1990s of the last century. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1806-9282.65.3.319DOI Listing
March 2019
1 Read

Emotional intelligence and schizophrenia spectrum disorders: a critical review.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):94-102. Epub 2019 Apr 11.

Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Introduction: Emotional intelligence (EI) is a theoretical construct postulated by Mayer and Salovey to designate the ability to perceive, understand, use and manage emotions. The study of EI in schizophrenia offers new insights into the disorder's cognitive and functional impacts.

Objectives: To comprehensively review studies analyzing EI impairment in schizophrenia spectrum disorders using standardized instruments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/2237-6089-2018-0001DOI Listing

A critical literature review on emotional intelligence in addiction.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):87-93. Epub 2019 Apr 1.

Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Introduction: Emotional intelligence (EI) has been defined as the ability to perceive, understand, use and manage emotions. Studying EI could potentially be useful in understanding addictive behaviors as well as for designing and planning interventions.

Objectives: To conduct a critical review on EI impairment in addiction disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/2237-6089-2018-0002DOI Listing
  • Page 1 of 15828