781,111 results match your criteria Critical care London England[Journal]


The Neuroprotective Peptide PACAP1-38 Contributes to Horizontal Cell Development in Postnatal Rat Retina.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):770-778

Department of Experimental Zoology and Neurobiology, University of Pécs, Pécs, Hungary.

Purpose: PACAP1-38, a member of the secretin/glucagon superfamily, is expressed in the developing retina with documented neuroprotective effects. However, its function in retinal cell differentiation has yet to be elucidated. Our goals, therefore, were to identify PAC1 expressing cells morphologically, investigate the PACAP1-38 action functionally, and establish PACAP1-38 regulated events developmentally during the first postnatal week in rat retina. Read More

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http://dx.doi.org/10.1167/iovs.18-25719DOI Listing
February 2019

Optimising the biocompatibility of 3D printed photopolymer constructs in vitro and in vivo.

Biomed Mater 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery, University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, AUSTRALIA.

3D printing is a rapid and accessible fabrication technology that engenders creative custom design solutions for cell scaffolds, perfusion systems and cell culture systems for tissue engineering. Critical to its success is the biocompatibility of the materials used, which should allow long-term tissue culture without affecting cell viability or inducing an inflammatory response for in vitro and in vivo applications. Polyjet 3D printers offer arguably the highest resolution with the fewest design constraints of any commercially available 3D printing systems. Read More

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http://dx.doi.org/10.1088/1748-605X/ab09c4DOI Listing
February 2019

Toward Tissue-engineering of Nasal Cartilages.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA, 92697-2715, USA. Electronic address:

Nasal cartilage pathologies are common; for example, up to 80% of people are afflicted by deviated nasal septum conditions. Because cartilage provides the supportive framework of the nose, afflicted patients suffer low quality of life. To correct pathologies, graft cartilage is often required. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.025DOI Listing
February 2019

Rational "Error Elimination" Approach to Evaluating Molecular Barcoded Next-Generation Sequencing Data Identifies Low-Frequency Mutations in Hematologic Malignancies.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Hematopathology, The University of Texas MD Anderson Cancer Center, Houston; Baylor Miraca Genetics Laboratories. Electronic address:

The emergence of highly sensitive molecular diagnostic approaches such as droplet digital PCR has allowed the accurate identification of low-frequency variant alleles in clinical specimens; however, the multiplex capabilities of droplet digital PCR for variant detection are inadequate. The incorporation of molecular barcodes or unique IDs into next-generation sequencing libraries through PCR has enabled the detection of low-frequency variant alleles across multiple genomic regions. However, rational library preparation and sequencing data analytical strategies that integrate molecular barcodes have rarely been applied to clinical settings. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.008DOI Listing
February 2019

Sex biased expression of anti-Mullerian hormone (amh) gene in a live bearing fish, Gambusia holbrooki: Evolutionary implications and potential role in sex differentiation.

Comp Biochem Physiol B Biochem Mol Biol 2019 Feb 19. Epub 2019 Feb 19.

Institute for Marine and Antarctic Studies (IMAS), University of Tasmania, TAS, Australia; Inland Fisheries and Services (IFS), TAS, Australia.

The amh, a member of transforming growth factor-β (TGF-β) family, is known to play a critical role in vertebrate male sex differentiation, with its paralogue/s evolving to determine sex in few heterogametic (XX/XY) teleosts. However, it remains relatively unexplored in the reproductively unique live bearing teleosts. Therefore, this study comparatively examined the structure and content of G. Read More

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http://dx.doi.org/10.1016/j.cbpb.2019.02.004DOI Listing
February 2019

Prevalence of antibodies to lung self-antigens (Kα1 tubulin and collagen V) and donor specific antibodies to HLA in lung transplant recipients and implications for lung transplant outcomes: Single center experience.

Transpl Immunol 2019 Feb 19. Epub 2019 Feb 19.

Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Purpose: For patients with end stage lung disease, lung transplantation (LT) remains the only definitive treatment option. Long term survival post LT is limited by acute and chronic allograft dysfunction. Antibodies to lung self-antigens Kα1Tubulin and collagen V (autoantibodies) have been implicated in adverse outcomes post LT. Read More

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http://dx.doi.org/10.1016/j.trim.2019.02.006DOI Listing
February 2019

Symptom Burden and Palliative Care Needs among High Risk Veterans with Multi-morbidity.

J Pain Symptom Manage 2019 Feb 19. Epub 2019 Feb 19.

Department of Veterans Affairs, Puget Sound Health Care System, Health Services R&D; University of Washington, School of Medicine, Pulmonary and Critical Care Medicine Division.

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.011DOI Listing
February 2019

Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China. Electronic address:

WDR1 is a major cofactor of the actin depolymerizing factor (ADF)/cofilin, accelerating ADF/cofilin-mediated actin disassembly. We had previously showed that WDR1-mediated actin dynamics is required for postnatal myocardial growth and adult myocardial maintenance in mice, in which the detailed phenotypes of adult cardiomyocyte-specific Wdr1 deletion mice had not been analyzed. In this study, we systematically analyzed the role of Wdr1 in adult mouse heart. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.023DOI Listing
February 2019

Silencing of ionotropic receptor 25a decreases chemosensory activity in the salmon louse Lepeophtheirus salmonis during the infective stage.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Institute of Marine Research, Austevoll Research Station, Saugeneset 16, 5392 Storebø, Norway. Electronic address:

Chemoreception is critical for marine ectoparasites - such as salmon lice (Lepeophtheirus salmonis) - to identify and locate salmonid hosts. The molecular receptors that parasites employ to detect host-specific chemical stimuli from hosts (kairomones) have not been well characterised. In the present study, transcription of the sea louse Ionotropic receptor 25a (IR25a) was blocked to evaluate whether it functions as a chemical-perception related gene for a specific chemical cue from the Atlantic salmon host. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.012DOI Listing
February 2019

Improvement in lip appearance (lateral and frontal aspects) following mandibular setback surgery.

J Stomatol Oral Maxillofac Surg 2019 Feb 19. Epub 2019 Feb 19.

School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Oral and Maxillofacial Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address:

Itroduction: The postoperative facial profile is critical for patients who undergo orthognathic surgery. The present study investigated the improvement in lip appearance (lateral and frontal aspects) following mandibular setback surgery.

Material And Methods: Thirty-one patients with mandibular prognathism underwent mandibular setback surgery. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.010DOI Listing
February 2019

Visual attention and neural oscillations in reading and dyslexia: are they possible targets for remediation?

Neuropsychologia 2019 Feb 19. Epub 2019 Feb 19.

Visual and Cognitive Neuroscience Unit, Department of Optometry & Vision Sciences and Melbourne Neuroscience Institute, University of Melbourne, Parkville, Vic 3010, Australia. Electronic address:

After decades of finding a range of cognitive functions both in visual and phonological domains that correlate with reading performance, there are in recent years attempts to solve the causation versus correlation dilemma in finding a core deficit in developmental dyslexia (DD). Thus, longitudinal studies that aim to predict reading difficulties from studies done in pre-reading years and reading-level matched studies that try to factor out the effect due to lack of reading in DD cohorts, have helped identify two possible candidates to be added to the classical phonological suspect. One is a deficit in visuo-spatial attention that underpins our ability to selectively attend to individual objects in a cluttered world, which is fundamental in being able to identify letters and words in a text such as the one you are reading now. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.02.009DOI Listing
February 2019

Transcriptomic insight into antimicrobial peptide factors involved in the prophylactic immunity of crowded Mythimna separata larvae.

Dev Comp Immunol 2019 Feb 19. Epub 2019 Feb 19.

College of Horticulture and Plant Protection, Yangzhou University, Wenhui East Road, NO. 48, Yangzhou, Jiangsu Province, 225009, China.

Similar to pathogenic infection, a high population density alters insect prophylactic immunity. Antimicrobial peptides (AMPs) are known to play critical roles in an insect's humoral immune response to microbial infection. We applied RNA sequencing to investigate differential gene expression levels in fat body and hemocyte samples from larvae reared in high- (10 larvae per jar) and low-density (1 larva per jar) conditions; the samples exhibited density-dependent prophylaxis. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.009DOI Listing
February 2019

Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression.

Chem Biol Interact 2019 Feb 19. Epub 2019 Feb 19.

Department of Nutrition, UNC-Chapel Hill, UNC Nutrition Research Institute, Kannapolis, NC, 28081, United States.

ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is the enzyme in folate metabolism commonly downregulated in human cancers. One of the mechanisms of the enzyme downregulation is methylation of the promoter of the ALDH1L1 gene. Recent studies underscored ALDH1L1 as a candidate tumor suppressor and potential marker of aggressive cancers. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.013DOI Listing
February 2019

The complex between a multi-crossover DNA nanostructure, PX-DNA, and T7 endonuclease I.

Biochemistry 2019 Feb 22. Epub 2019 Feb 22.

Paranemic crossover (PX) DNA is a four-stranded multi-crossover structure that has been implicated in recombination-independent recognition of homology. Although existing evidence has suggested that PX is the DNA motif in homologous pairing (HP), the conclusion has not yet been unambiguous. Further investigation is needed, but will require development of new tools. Read More

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http://dx.doi.org/10.1021/acs.biochem.9b00057DOI Listing
February 2019

Growth arrest and DNA damage 45γ is required for caspase-dependent renal tubular cell apoptosis.

PLoS One 2019 22;14(2):e0212818. Epub 2019 Feb 22.

Department of Nephrology, Ajou University School of Medicine, Suwon, Korea.

Background: Growth Arrest and DNA Damage 45γ (GADD45γ) is a member of the DNA damage-inducible gene family which responds to environmental stresses. Apoptosis is a critical mode of renal tubular cell death in nephrotoxin-induced acute kidney injury. In this study, we investigated the role of GADD45γ in renal tubular cell apoptosis induced by nephrotoxic drugs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212818PLOS
February 2019

Assessment of the effectiveness of BG-Sentinel traps baited with CO2 and BG-Lure for the surveillance of vector mosquitoes in Miami-Dade County, Florida.

PLoS One 2019 22;14(2):e0212688. Epub 2019 Feb 22.

Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, United States of America.

Vector-borne diseases are an increasing issue to public health, endangering billions of people worldwide. Controlling vector mosquitoes is widely accepted as the most effective way to prevent vector-borne disease outbreaks. Mosquito surveillance is critical for the development of control strategies under the integrated vector management framework. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212688PLOS
February 2019

Effective coverage of essential antenatal care interventions: A cross-sectional study of public primary healthcare clinics in the West Bank.

PLoS One 2019 22;14(2):e0212635. Epub 2019 Feb 22.

Global Health Cluster, Division for Health Services, Norwegian Institute of Public Health, Oslo, Norway.

Background: The proportion of women attending four or more antenatal care (ANC) visits is widely used for monitoring, but provides limited information on quality of care. Effective coverage metrics, assessing if ANC interventions are completely delivered, can identify critical gaps in healthcare service delivery. We aimed to measure coverage of at least one screening and effective coverage of ANC interventions in the public health system in the West Bank, Palestine, and to explore associations between infrastructure-related and maternal sociodemographic variables and effective coverage. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212635PLOS
February 2019

Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data.

PLoS One 2019 22;14(2):e0212665. Epub 2019 Feb 22.

Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

Background: Rapid antibiotic administration is known to improve sepsis outcomes, however early diagnosis remains challenging due to complex presentation. Our objective was to develop a model using readily available electronic health record (EHR) data capable of recognizing infant sepsis at least 4 hours prior to clinical recognition.

Methods And Findings: We performed a retrospective case control study of infants hospitalized ≥48 hours in the Neonatal Intensive Care Unit (NICU) at the Children's Hospital of Philadelphia between September 2014 and November 2017 who received at least one sepsis evaluation before 12 months of age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212665PLOS
February 2019

Tuberculosis in Brazil and cash transfer programs: A longitudinal database study of the effect of cash transfer on cure rates.

PLoS One 2019 22;14(2):e0212617. Epub 2019 Feb 22.

Laboratory of Epidemiology of Federal University of Espírito Santo, Vitória/ES, Brazil.

Introduction: Tuberculosis incidence is disproportionately high among people in poverty. Cash transfer programs have become an important strategy in Brazil fight inequalities as part of comprehensive poverty alleviation policies. This study was aimed at assessing the effect of being a beneficiary of a governmental cash transfer program on tuberculosis (TB) treatment cure rates. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212617PLOS
February 2019

Autophagic flux modulation by Wnt/β-catenin pathway inhibition in hepatocellular carcinoma.

PLoS One 2019 22;14(2):e0212538. Epub 2019 Feb 22.

Department of Surgery, Transplant Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America.

Autophagy targets cellular components for lysosomal-dependent degradation in which the products of degradation may be recycled for protein synthesis and utilized for energy production. Autophagy also plays a critical role in cell homeostasis and the regulation of many physiological and pathological processes and prompts this investigation of new agents to effect abnormal autophagy in hepatocellular carcinoma (HCC). 2,5-Dichloro-N-(2-methyl-4-nitrophenyl) benzenesulfonamide (FH535) is a synthetic inhibitor of the Wnt/β-catenin pathway that exhibits anti-proliferative and anti-angiogenic effects on different types of cancer cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212538PLOS
February 2019

Dynamic Advisor-Based Ensemble (dynABE): Case study in stock trend prediction of critical metal companies.

Authors:
Zhengyang Dong

PLoS One 2019 22;14(2):e0212487. Epub 2019 Feb 22.

Middlesex School, Concord, Massachusetts, United States of America.

Stock trend prediction is a challenging task due to the market's noise, and machine learning techniques have recently been successful in coping with this challenge. In this research, we create a novel framework for stock prediction, Dynamic Advisor-Based Ensemble (dynABE). dynABE explores domain-specific areas based on the companies of interest, diversifies the feature set by creating different "advisors" that each handles a different area, follows an effective model ensemble procedure for each advisor, and combines the advisors together in a second-level ensemble through an online update strategy we developed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212487PLOS
February 2019

Ideating iDNA: Lessons and limitations from leeches in legacy collections.

PLoS One 2019 22;14(2):e0212226. Epub 2019 Feb 22.

Department of Biological Sciences, Fordham University, Bronx, New York, United States of America.

Indirect methods for conducting faunal inventories present great promise, and genomic inventories derived from environmental sources (eDNA) are improving. Invertebrate ingested DNA (iDNA) from terrestrial leeches in the family Haemadipsidae has shown potential for surveying vertebrates and biodiversity monitoring in protected areas. Here we present an initial, and critical, evaluation of the limitations and biases of current iDNA protocols for biodiversity monitoring using both standard and NGS barcoding approaches. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212226PLOS
February 2019

CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review.

PLoS One 2019 22;14(2):e0212198. Epub 2019 Feb 22.

Friedrich Baur Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.

Introduction: The system of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (cas) is a new technology that allows easier manipulation of the genome. Its potential to edit genes opened a new door in treatment development for incurable neurological monogenic diseases (NMGDs). The aim of this systematic review was to summarise the findings on the current development of CRISPR-cas for therapeutic purposes in the most frequent NMGDs and provide critical assessment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212198PLOS
February 2019

Users' preferences and perceptions of the comprehensibility and readability of medication labels.

PLoS One 2019 22;14(2):e0212173. Epub 2019 Feb 22.

Department of Production and Control of Medicines, School of Pharmacy, UFRGS, Porto Alegre, RS, Brazil.

Objective: To evaluate the labeling preferences of medication users and characterize their perceptions of the comprehensibility and readability of medication labels.

Methods: We conducted a population-based cross-sectional study of medication users aged 18 years or older in 10 Brazilian capital cities. Perceptions of the comprehensibility and readability of medication labels in relation to sociodemographic characteristics were evaluated by Poisson regression models with robust variance. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212173PLOS
February 2019

Italian norms and naming latencies for 357 high quality color images.

PLoS One 2019 22;14(2):e0209524. Epub 2019 Feb 22.

Department of Life Sciences, Università di Trieste, Trieste, Italy.

In the domain of cognitive studies on the lexico-semantic representational system, one of the most important means of ensuring effective experimental designs is using ecological stimulus sets accompanied by normative data on the most relevant variables affecting the processing of their items. In the context of image sets, color photographs are particularly suited to this purpose as they reduce the difficulty of visual decoding processes that may emerge with traditional image sets of line drawings. This is especially so in clinical populations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209524PLOS
February 2019

Repository of Enriched Structures of Proteins Involved in the Red Blood Cell Environment (RESPIRE).

PLoS One 2019 22;14(2):e0211043. Epub 2019 Feb 22.

Institut National de la Transfusion Sanguine, Paris, France.

The Red Blood Cell (RBC) is a metabolically-driven cell vital for processes such a gas transport and homeostasis. RBC possesses at its surface exposing antigens proteins that are critical in blood transfusion. Due to their importance, numerous studies address the cell function as a whole but more and more details of RBC structure and protein content are now studied using massive state-of-the art characterisation techniques. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211043PLOS
February 2019

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion.

PLoS Biol 2019 Feb 22;17(2):e3000154. Epub 2019 Feb 22.

Faculty of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Cyclic nucleotide signalling is a major regulator of malaria parasite differentiation. Phosphodiesterase (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the parasite, but the mechanisms by which cyclic AMP (cAMP) is regulated remain enigmatic. Here, we demonstrate that Plasmodium falciparum phosphodiesterase β (PDEβ) hydrolyses both cAMP and cGMP and is essential for blood stage viability. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000154DOI Listing
February 2019

Drug treatment strategies for insomnia in patients with post-traumatic stress disorder.

Expert Opin Pharmacother 2019 Feb 22:1-9. Epub 2019 Feb 22.

b Department of Medicine , VA Western New York Healthcare System , Buffalo , NY , USA.

Introduction: Insomnia is among the most reported sleep disturbances in patients with post-traumatic stress disorder (PTSD). The pervasiveness of this disorder among trauma-inflicted civilians and military personnel has been associated with reduced quality of life, impaired psychosocial functioning including cognitive impairments, negative mood swings, cardiovascular complications, and increased utilization of medical services. Areas covered: This review describes the current state of science with respect to the impact of the most dispensed pharmacological interventions for posttraumatic insomnia. Read More

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http://dx.doi.org/10.1080/14656566.2019.1574745DOI Listing
February 2019

IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment.

J Histochem Cytochem 2019 Feb 22:22155419833334. Epub 2019 Feb 22.

UD of Biochemistry and Molecular Biology.

Glioblastoma (GB) is the most frequently occurring and aggressive primary brain tumor. Glioma stem cells (GSCs) and astrocytoma cells are the predominant malignant cells occurring in GB besides a highly heterogeneous population of migrating, neovascularizing and infiltrating myeloid cells that forms a complex tumor microenvironment (TME). Cross talk between the TME cells is pivotal in the biology of this tumor and, consequently, adaptor proteins at critical junctions of signaling pathways may be crucial. Read More

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http://dx.doi.org/10.1369/0022155419833334DOI Listing
February 2019

Catastrophic Mortality, Allee Effects, and Marine Protected Areas.

Am Nat 2019 Mar 1;193(3):391-408. Epub 2019 Feb 1.

For many species, reproductive failure may occur if abundance drops below critical Allee thresholds for successful breeding, in some cases impeding recovery. At the same time, extreme environmental events can cause catastrophic collapse in otherwise healthy populations. Understanding what natural processes and management strategies may allow for persistence and recovery of natural populations is critical in the face of expected climate change scenarios of increased environmental variability. Read More

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http://dx.doi.org/10.1086/701781DOI Listing

Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.

FASEB J 2019 Feb 22:fj201801682R. Epub 2019 Feb 22.

Centre for Biological Timing, Faculty of Biology, Health and Medicine, University of Manchester, Manchester, United Kingdom.

Pulmonary airway epithelial cells (AECs) form a critical interface between host and environment. We investigated the role of the circadian clock using mice bearing targeted deletion of the circadian gene brain and muscle ARNT-like 1 ( Bmal1) in AECs. Pulmonary neutrophil infiltration, biomechanical function, and responses to influenza infection were all disrupted. Read More

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http://dx.doi.org/10.1096/fj.201801682RDOI Listing
February 2019

β-Arrestin-2-ERK1/2 cPLAα axis mediates TLR4 signaling to influence eicosanoid induction in ischemic brain.

FASEB J 2019 Feb 22:fj201802020R. Epub 2019 Feb 22.

Department of Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.

LPS has been shown to elicit neuroinflammation associated with the up-regulation of the eicosanoid pathway in animal models; however, the regulatory mechanisms of TLR4 in brain neuroinflammatory conditions remain elusive. β-Arrestins are key regulators of the GPCR signaling pathway and are involved in the leukotriene B4-induced leukocyte migration to initiate inflammatory response. However, the roles of β-arrestins in eicosanoid regulation and related diseases are not clear. Read More

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http://dx.doi.org/10.1096/fj.201802020RDOI Listing
February 2019

Reactive oxygen species modulate sodium-coupled neutral amino acid transporter 1 (SNAT1) expression in piglet pulmonary artery endothelial cells.

Am J Physiol Heart Circ Physiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Pediatrics, University of Utah Health, United States.

Rationale: We have previously shown that the sodium-coupled neutral amino acid transporter, SNAT1, modulates NO production in pulmonary arterial endothelial cells (PAECs) from newborn piglets. Specifically, the ability to increase NO production in response to the L-arginine-NO precursor, L-citrulline is dependent on SNAT1 expression. Elucidating factors that regulate SNAT1 expression in PAEC could provide new insights and therapeutic targets relevant to NO production. Read More

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http://dx.doi.org/10.1152/ajpheart.00674.2018DOI Listing
February 2019

Non-Invasive Imaging Biomarker Identifies Small Airway Damage in Severe COPD.

Am J Respir Crit Care Med 2019 Feb 22. Epub 2019 Feb 22.

University of Michigan, Pulmonary & Critical Care, Ann Arbor, Michigan, United States ;

Rationale: Evidence suggests damage to small airways is a key pathologic lesion in chronic obstructive pulmonary disease (COPD). Computed Tomography (CT) densitometry has been demonstrated to identify emphysema, but no such studies have been performed linking an imaging metric to small airway abnormality.

Objectives: To correlate ex vivo Parametric Response Mapping (PRM) analysis to in vivo lung tissue measurements of patients with severe COPD treated by lung transplantation and controls. Read More

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http://dx.doi.org/10.1164/rccm.201811-2083OCDOI Listing
February 2019

On the Solute-Induced Structure-Making/Breaking Effect Rigorous Links Between Microscopic Behavior, Solvation Properties, and Solution Non-Ideality.

Authors:
Ariel A Chialvo

J Phys Chem B 2019 Feb 22. Epub 2019 Feb 22.

We studied the solute-induced perturbation of the solvent environment around a solute species from a microscopic viewpoint, and propose a novel approach to the understanding of the structure-making/breaking process, regardless of the type and nature of the solute-solvent interactions. Based on the Kirkwood-Buff fluctuation formalism we present a rigorous statistical mechanics description of the evolution of the solvent structure around the solute, analyze its response to small perturbations of the (TP) state conditions and composition of the system, and make direct connections between a few equivalent micro- and macroscopic manifestations as probes for, and targets of, experimental measurements. We illustrate the analysis with theoretical results from integral equation calculations of model fluids, and experimental evidence from available data for a variety of aqueous electrolyte and non-electrolyte real fluid solutions. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b00364DOI Listing
February 2019

Tuning interaction parameters of thermoplastic polyurethanes in a binary solvent to achieve precise control over micro-phase separation.

J Chem Inf Model 2019 Feb 22. Epub 2019 Feb 22.

Thermoplastic polyurethanes (TPUs) are designed using a large variety of basic building blocks but are only synthesized in a limited number of solvent systems. Understanding the behavior of the copolymers in a selected solvent system is of particular interest to tune the intricate balance of micro-phase separation/mixing, which is the key mechanism behind the structure formation in TPUs. Here, we present a computationally efficient approach for selecting TPU building blocks and solvents based on their Flory-Huggins interaction parameters for a precise control over the micro-phase separation/mixing. Read More

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http://dx.doi.org/10.1021/acs.jcim.8b00781DOI Listing
February 2019

Interactions of an Anti-sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.

Bioconjug Chem 2019 Feb 22. Epub 2019 Feb 22.

The pathophysiology associated with sickle cell disease (SCD) includes hemolytic anemia, vaso-occlusive events, and ultimately end organ damage set off by the polymerization of deoxygenated hemoglobin S (HbS) into long fibers and sickling of red blood cells (RBCs). One approach toward mitigating HbS polymerization is to pharmacologically stabilize the oxygenated (R) con-formation of HbS and thereby reduce sickling frequency and SCD pathology. GBT440 is an α subunit specific modifying agent that has recently been reported to increase HbS oxygen binding affinity and consequently delay in vitro polymerization. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00130DOI Listing
February 2019

3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia.

Laryngoscope 2019 Feb 22. Epub 2019 Feb 22.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.

Objectives/hypothesis: To report the clinical safety and efficacy of three-dimensional (3D)-printed, patient-specific, bioresorbable airway splints in a cohort of critically ill children with severe tracheobronchomalacia.

Study Design: Case series.

Methods: From 2012 to 2018, 15 subjects received 29 splints on their trachea, right and/or left mainstem bronchi. Read More

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http://dx.doi.org/10.1002/lary.27863DOI Listing
February 2019

NK cell immune responses differ after prime and boost vaccination.

J Leukoc Biol 2019 Feb 22. Epub 2019 Feb 22.

CEA, Université Paris Sud 11, INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT, IBFJ, CEA, Fontenay-aux-Roses, France.

A better understanding of innate responses induced by vaccination is critical for designing optimal vaccines. Here, we studied the diversity and dynamics of the NK cell compartment after prime-boost immunization with the modified vaccinia virus Ankara using cynomolgus macaques as a model. Mass cytometry was used to deeply characterize blood NK cells. Read More

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http://doi.wiley.com/10.1002/JLB.4A1018-391RR
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http://dx.doi.org/10.1002/JLB.4A1018-391RRDOI Listing
February 2019
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The Management of Diabetes in Everyday Life (MODEL) program: development of a tailored text message intervention to improve diabetes self-care activities among underserved African-American adults.

Transl Behav Med 2019 Feb 22. Epub 2019 Feb 22.

University of Tennessee Health Science Center, Memphis, TN, USA.

Tailoring health-related materials is an effective mechanism to encourage behavior change; however, little research has described processes and critical characteristics for effective tailoring in underserved populations. The purpose of this study is to describe a process using input from content experts and lay patient advisors to tailor text messages focused on improving self-care behaviors of African-American adults with diabetes and identify characteristics of messages perceived to be most effective. An initial library of tailorable messages was created using theory-based approaches, expert opinion, and publicly available materials. Read More

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http://dx.doi.org/10.1093/tbm/ibz024DOI Listing
February 2019

Obstructive Sleep Apnea and Longitudinal Alzheimer's disease biomarker changes.

Sleep 2019 Feb 22. Epub 2019 Feb 22.

Center for Brain Health, Department of Psychiatry, NYU Langone Medical Center, New York, NY.

Study Objectives: To determine the effect of self-reported clinical diagnosis of Obstructive Sleep Apnea (OSA) on longitudinal changes in brain amyloid-PET and CSF-biomarkers (Aβ42, T-tau and P-tau) in cognitively normal (NL), mild cognitive impairment (MCI) and Alzheimer's Disease (AD) elderly.

Methods: Longitudinal study with mean follow-up time of 2.52±0. Read More

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http://dx.doi.org/10.1093/sleep/zsz048DOI Listing
February 2019

A systematic review of the effects of implementing clinical pathways supported by health information technologies.

J Am Med Inform Assoc 2019 Feb 22. Epub 2019 Feb 22.

Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

Objective: Health information technology (HIT) interventions include electronic patient records, prescribing, and ordering systems. Clinical pathways are multidisciplinary plans of care that enable the delivery of evidence-based healthcare. Our objective was to systematically review the effects of implementing HIT-supported clinical pathways. Read More

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http://dx.doi.org/10.1093/jamia/ocy176DOI Listing
February 2019

Is there a Threshold that Triggers Cortical Arousals in Obstructive Sleep Apnea.

Sleep 2019 Feb 22. Epub 2019 Feb 22.

Pulmonary, Critical Care and Sleep Division. University of California at San Diego, CA, United States.

Study Objectives: To determine whether there is a consistent epiglottic pressure value that predicts respiratory arousal from sleep.

Methods: 31 patients with obstructive sleep apnea underwent overnight polysomnography while instrumented with an epiglottic catheter to measure airway pressures. Nadir epiglottic pressures during respiration events (obstructive apneas/hypopneas) terminated with or without arousals were compared. Read More

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http://dx.doi.org/10.1093/sleep/zsz047DOI Listing
February 2019

Empowering Young People Living With Juvenile Idiopathic Arthritis to Better Communicate With Families and Care Teams: Content Analysis of Semistructured Interviews.

JMIR Mhealth Uhealth 2019 Feb 22;7(2):e10401. Epub 2019 Feb 22.

Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN, United States.

Background: Young people living with juvenile idiopathic arthritis (JIA) face a number of communication barriers for achieving optimal health as they transition from pediatric care into adult care. Despite growing interest in mobile or wireless technologies to support health (mHealth), it is uncertain how these engagement tools might support young people, their families, and care teams to optimize preference-based treatment strategies.

Objective: This study aims to examine how an mHealth patient support system (mPSS) might foster partnership between young people living with JIA, their families, and care teams. Read More

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http://dx.doi.org/10.2196/10401DOI Listing
February 2019

Limitation of Life-Sustaining Care in the Critically Ill: A Systematic Review of the Literature.

J Hosp Med 2019 Feb 20;14:E1-E8. Epub 2019 Feb 20.

Indiana University Center for Aging Research, Indianapolis Indiana.

When life-sustaining treatments (LST) are no longer effective or consistent with patient preferences, limitations may be set so that LSTs are withdrawn or withheld from the patient. Many studies have examined the frequency of limitations of LST in intensive care unit (ICU) settings in the past 30 years. This systematic review describes variation and patient characteristics associated with limitations of LST in critically ill patients in all types of ICUs in the United States. Read More

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http://dx.doi.org/10.12788/jhm.313DOI Listing
February 2019

Cameras on beds: The ethics of surveillance in nursing home rooms.

AJOB Empir Bioeth 2019 Feb 22:1-8. Epub 2019 Feb 22.

c Cornell University , Information Science , Ithaca , New York , USA.

Surveillance cameras are increasingly being deployed in nursing homes and assisted living facilities, with insufficient attention to what is ethically fraught about this way of assuaging concerns about abuse and other personnel challenges. With seven state laws now regulating camera monitoring and more on the way, it is urgent for us to consider the ethical implications of how we use technology to keep older adults safe. Drawing on findings from the first facility survey on this topic, we address three ethical issues: the risk that in-room cameras pose to residents' privacy and dignity, the risk of undermining care workers' sense of being fiduciaries for residents, and the probable extension of camera use by facilities to monitor staff and residents. Read More

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http://dx.doi.org/10.1080/23294515.2019.1568320DOI Listing
February 2019

Posttraumatic growth experiences and its contextual factors in women with breast cancer: An integrative review.

Health Care Women Int 2019 Feb 22:1-27. Epub 2019 Feb 22.

c School of Nursing and Midwifery , Latrobe University , Melbourne , VIC , Australia.

In this article, we synthesize current research that examines determinants and manifestations of posttraumatic growth (the phenomenon of posttraumatic growth can be embodied in several domains) in women with breast cancer. The findings of the integrative literature review may contribute to facilitating person-centered oncology care by raising health care professionals' awareness and understanding of posttraumatic growth phenomenon among breast cancer survivors. The identification of factors contributing to posttraumatic growth and manifestations of posttraumatic growth are important in increasing the effectiveness of interventions in supporting women during their breast cancer journey. Read More

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http://dx.doi.org/10.1080/07399332.2019.1578360DOI Listing
February 2019

Mental health training, attitudes toward support, and screening positive for mental disorders.

Cogn Behav Ther 2019 Feb 22:1-19. Epub 2019 Feb 22.

j Hill / Levene Schools of Business, Faculty of Business Administration , University of Regina , Regina , SK , Canada.

Public Safety Personnel (PSP; e.g. correctional workers, dispatchers, firefighters, paramedics, police) are frequently exposed to potentially traumatic events (PTEs). Read More

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http://dx.doi.org/10.1080/16506073.2019.1575900DOI Listing
February 2019

Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NOX Enzymes and Mitochondria.

Antioxid Redox Signal 2019 Feb 22. Epub 2019 Feb 22.

University of Vermont, Pathology , D205 Given Medical Building , 89 Beaumont Avenue , Burlington , Burlington, Vermont, United States , 05405 ;

Significance: Idiopathic pulmonary fibrosis (IPF) is a progressive age-related lung disease with a median survival of only 3 years after diagnosis. The pathogenic mechanisms behind IPF are not clearly understood and current therapeutic approaches have not been successful in improving disease outcomes. Recent advances: IPF is characterized by increased production of reactive oxygen species (ROS), primarily by NADPH oxidases (NOXes) and mitochondria, as well as altered antioxidant defenses. Read More

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http://dx.doi.org/10.1089/ars.2019.7742DOI Listing
February 2019

Charge Density in Enzyme Active Site as a Descriptor of Electrostatic Preorganization.

J Chem Inf Model 2019 Feb 22. Epub 2019 Feb 22.

Large protein macromolecules in enzymatic catalysis have been shown to exert a specific electric field that reduces the reorganization energy upon barrier crossing and thus reduces the reaction free energy barrier. In this work we suggest that the charge density in the active site of an enzyme investigated using formalisms embodied by the quantum theory of atoms in molecules (QTAIM) provides a sensitive and quantum mechanically rigorous probe of electrostatic preorganization. We focus on the active site of ketosteroid isomerase, a well-studied enzyme for which electrostatic preorganization has been modeled theoretically and studied experimentally. Read More

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http://dx.doi.org/10.1021/acs.jcim.8b00958DOI Listing
February 2019
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