769,668 results match your criteria Critical care London England[Journal]


Peak Oxygen Uptake in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Meta-Analysis.

Int J Sports Med 2018 Dec 17. Epub 2018 Dec 17.

School of Health and Social Care, Teesside University, Middlesbrough, United Kingdom of Great Britain and Northern Ireland.

To evaluate the magnitude of the difference in VO between patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) and apparently healthy controls, 7 databases (Cochrane, PubMed, PsycINFO, Web of Knowledge, Embase, Scopus, Medline) were searched for articles published up to March 2018. Search terms included "chronic fatigue syndrom*"AND ("peak" OR "maxim*" OR "max") AND ("oxygen uptake" OR "oxygen consumption" OR "VO2peak" or "VO2max". Eligibility criteria were adults>18 y with clinically diagnosed CFS/ME, with VO measured in a maximal test and compared against an apparently healthy control group. Read More

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December 2018

Topological description of the solidification of undercooled fluids and the temperature dependence of the thermal conductivity of crystalline and glassy solids above approximately 50 K.

J Phys Condens Matter 2018 Dec 17. Epub 2018 Dec 17.

Department of Materials Science and Engineering, Carnegie-Mellon University, Pittsburgh, Pennsylvania, UNITED STATES.

Topological origins of the thermal transport properties of crystalline and non-crystalline solid states are considered herein, by the adoption of a quaternion orientational order parameter to describe solidication. Global orientational order, achieved by spontaneous symmetry breaking (SSB), is prevented at nite temperatures for systems that exist in restricted dimensions (Mermin-Wagner theorem). Just as complex ordered systems exist in restricted dimensions in 2D and 1D, owing to the dimensionality of the order parameter, quaternion ordered systems in 4D and 3D exist in restricted dimensions. Read More

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December 2018

Unravel a neuroactive sHA sulfation pattern with neurogenesis activity by a library of defined oligosaccharides.

Eur J Med Chem 2018 Dec 4;163:583-596. Epub 2018 Dec 4.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, 100191, Haidian District, Beijing, China. Electronic address:

Sulfated hyaluronic acid (sHA) is chemically synthetic mimetic of glycosaminoglycan (GAG) presenting promising biological functions. Specific sulfation pattern, termed as sulfation code plays critical roles in regulating the binding mode between GAG and proteins. As a structural analogue of chondroitin sulfate (CS), sHA bears much higher molecular weight and is nearly free of other proteoglycan contaminants. Read More

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December 2018

Coupling stable isotopes and water chemistry to assess the role of hydrological and biogeochemical processes on riverine nitrogen sources.

Water Res 2018 Dec 6;150:418-430. Epub 2018 Dec 6.

College of Environmental & Resource Sciences, Zhejiang University, Hangzhou, 310058, China; Ministry of Education Key Laboratory of Environment Remediation and Ecological Health, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Accurate source identification is critical for optimizing water pollution control strategies. Although the dual stable isotope (N-NO/O-NO) approach has been widely applied for differentiating riverine nitrogen (N) sources, the relatively short-term (<1 yr) N-NO/O-NO records typically used in previous studies often hinders rigorous assessment due to high temporal variability associated with watershed N dynamics. Estimated contributions of legacy N sources in soils and groundwater to riverine N export by modeling approaches in many previous studies also lack validation from complementary information, such as multiple stable isotopes. Read More

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December 2018

Fabrication of bean dreg-derived carbon with high adsorption for methylene blue: Effect of hydrothermal pretreatment and pyrolysis process.

Bioresour Technol 2018 Dec 8;274:525-532. Epub 2018 Dec 8.

Department of Housing and Urban-Rural Development of Hunan Provincial, Changsha 410082, PR China.

This study explored the cooperative effects of hydrothermal or activators pretreatment and pyrolysis process on the chemical composition of bean dreg (BD)-derived carbon materials and its adsorption characteristics for methylene blue (MB) further. The results showed that hydrothermal assisted pyrolysis carbon with or without activator (HBK and HB) possess higher BET surface area than no hydrothermal assisted carbon (BKs and B, respectively). But surface area alone was not a critical factor contributing to MB adsorption, it also depends on strong electrostatic interaction and the hydrogen bonding interaction between N in MB combines with OH and COO group of adsorbent surface by pH-dependent adsorption and pseudo-second-order model. Read More

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December 2018

Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production.

Int Immunopharmacol 2018 Dec 14;67:211-219. Epub 2018 Dec 14.

Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China; Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China; National Clinical Research Center for Respiratory Diseases, Beijing 100029, China; Department of Respiratory Medicine, Capital Medical University, Beijing 100069, China; Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China. Electronic address:

Interleukin (IL)-1β and IL-18 play central and detrimental roles in the development of acute lung injury (ALI), and mammalian target of rapamycin (mTOR) is involved in regulating IL-1β and IL-18 production. However, it is not clear whether the mTOR specific inhibitor rapamycin can attenuate lipopolysaccharide (LPS)-induced ALI by modulating IL-1β and IL-18 production. In this study, we found that rapamycin ameliorated LPS-induced ALI by inhibiting NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated IL-1β and IL-18 secretion. Read More

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December 2018

Epilepsy and seizures in children with congenital heart disease: A prospective study.

Seizure 2018 Nov 26;64:50-53. Epub 2018 Nov 26.

Clinique d'Investigation Neuro-Cardiaque (CINC), CHU Sainte-Justine, Montreal, Canada.

Purpose: Children with complex congenital heart disease (CHD) experience high incidence of perioperative seizures. Population-based studies also report high epilepsy co-morbidity in CHD. Given the increasing survival of patients with CHD and the interference of seizures and epilepsy with the long-term outcomes, characterizing them in this population is of high relevance. Read More

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November 2018

Chemical characterization and source apportionment of PM personal exposure of two cohorts living in urban and suburban Beijing.

Environ Pollut 2018 Dec 4;246:225-236. Epub 2018 Dec 4.

College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Center for Excellence in Regional Atmospheric Environment, Chinese Academy of Sciences, Xiamen, 361021, China. Electronic address:

In the study, personal PM exposures and their source contributions were characterized for 159 subjects living in the Beijing Metropolitan area. The exposures and sources were examined as functions of residential location, season, vocation, cigarette smoking, and time spent outdoors. Sampling was performed for two categories of volunteers, guards and students, that lived in urban and suburban areas of Beijing. Read More

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December 2018

Development of postural stability limits: Anteroposterior and mediolateral postural adjustment mechanisms do not follow the same maturation process.

Hum Mov Sci 2018 Dec 14;63:164-171. Epub 2018 Dec 14.

Département de Kinésiologie, Université de Montréal, 2100, boul. Édouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Institut universitaire de gériatrie de Montréal, Université de Montréal, 2100, boul. Édouard-Montpetit, Montréal, Québec H3T 1J4, Canada. Electronic address:

There is increasing evidence that indicates a critical transition period for the maturation of postural control from the ages of 6-7 years. Some studies suggest that this transitional period may be explained by a change from a ballistic toward a sensory strategy, but the cause remains unknown. The purpose of this study was to investigate the influence of the transition period on dynamic postural control in a natural self-initiated leaning task under different sensory conditions. Read More

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December 2018

Behavioral and neural evidence on the processing of ambiguous adjective-noun dependencies in Korean sentence comprehension.

Brain Lang 2018 Dec 14;188:28-41. Epub 2018 Dec 14.

Dept. of Media and Communication, Konkuk Univeirsity, Seoul 5029, Republic of Korea; Brain and Cognition Research Center, Konkuk University, Seoul 5029, Republic of Korea. Electronic address:

In Korean, it is allowed for an adjective to modify a distant noun that appears after an intervening relative clause instead of an adjacent noun. The current study investigated the time course of syntactic and semantic integration between an adjective (A) and an adjacent noun (N1) and/or a distant noun (N2) during on-line reading comprehension of Korean sentences. Semantic congruence between adjectives and nouns were manipulated, such that A was congruent with both N1 and N2, either with N1 or N2, or with none of N1/N2. Read More

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December 2018

QSAR for baseline toxicity and classification of specific modes of action of ionizable organic chemicals in the zebrafish embryo toxicity test.

Aquat Toxicol 2018 Dec 5;207:110-119. Epub 2018 Dec 5.

UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany; Eberhard Karls University Tübingen, Center for Applied Geoscience, Environmental Toxicology Hölderlinstr. 12, 72074, Tübingen, Germany.

The fish embryo toxicity (FET) test with the zebrafish Danio rerio is widely used to assess the acute toxicity of chemicals thereby serving as animal alternative to the acute fish toxicity test. The minimal toxicity of neutral chemicals in the FET can be predicted with a previously published Quantitative Structure-Activity Relationship (QSAR) based on the liposome-water partition coefficient K. Such a QSAR may serve to plan toxicity testing and to evaluate whether an observed effect is caused by a specific mode of action (MoA). Read More

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December 2018

Benzo(a)pyrene inhibits the accumulation and toxicity of cadmium in subcellular fractions of Eisenia fetida.

Chemosphere 2018 Dec 11;219:740-747. Epub 2018 Dec 11.

College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR China; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Nanjing 210014, PR China. Electronic address:

Cadmium (Cd) and benzo [a]pyrene (BaP) often co-occur in the environment, and the critical body residue of organisms is used as an indicator of the toxic effects of contaminants. However, little is known about their distributions and toxicities when pollution of Cd and BaP are combined. Semi-static solution culture experiment was used to study the impacts of BaP on the subcellular distribution of the toxic metal Cd in the earthworm Eisenia fetida. Read More

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December 2018

Sublethal concentrations of chlorpyrifos induce changes in the thermal sensitivity and tolerance of anuran tadpoles in the toad Rhinella arenarum?

Chemosphere 2018 Dec 7;219:671-677. Epub 2018 Dec 7.

Departamento de Ecología Evolutiva, Estación Biológica de Doñana, CSIC, Avda. Américo Vespucio s/n, 41092, Sevilla, Spain. Electronic address:

Amphibians are considered one of the groups most susceptible to chemical contamination, therefore are good bio-indicators of aquatic pollution. Synergistic effects of temperature and pesticides have been found in amphibians determining amplified toxicity effect on survival and malformations with increasing temperatures. We studied the sensitivity of sublethal concentrations of chlorpyrifos in Rhinella arenarum tadpoles over on two fitness related thermal traits: locomotor swimming performance and thermal tolerance limits (CT = critical thermal maximum and CT = critical thermal minimum). Read More

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December 2018
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Maternal urinary benzophenones and infant birth size: Identifying critical windows of exposure.

Chemosphere 2018 Nov 28;219:655-661. Epub 2018 Nov 28.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Benzophenones (BPs) are widely used as ultraviolet absorbers and fragrance retention agents. Evidences from animal studies have suggested that exposure to BPs may affect fetal growth, but human data is limited and no study is concerning critical windows of BPs exposure throughout pregnancy in relation to fetal growth. We aimed to investigate the associations of prenatal exposure to BPs with birth size and examine the critical exposure windows of fetus development. Read More

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November 2018

Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: The most common immediate hypersensitivity to macrogols is associated with PEG 3350, however the epidemiology, mechanisms and cross-reactivity are poorly understood. Thousands of medications contain either PEGs or structurally similar polysorbates.

Objective: Our objective was to better understand the mechanism, cross-reactivity and scope of PEG hypersensitivity. Read More

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December 2018
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A systematic literature review and critical appraisal of epidemiological studies on outdoor air pollution and tuberculosis outcomes.

Environ Res 2018 Dec 7;170:33-45. Epub 2018 Dec 7.

School of Public Health, Faculty of Medicine, University of Queensland, Herston, Australia; Centre for Air Pollution, Energy and Health Research, Glebe, NSW, Australia.

Ambient air pollution is the leading environmental risk factor for disease globally. Air pollutants can increase the risk of some respiratory infections, but their effects on tuberculosis (TB) are unclear. In this systematic literature review, we aimed to assess epidemiological studies on the association between outdoor air pollutants and TB incidence, hospital admissions and death (collectively referred to here as 'TB outcomes'). Read More

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December 2018

Construct validity of six sentiment analysis methods in the text of encounter notes of patients with critical illness.

J Biomed Inform 2018 Dec 14. Epub 2018 Dec 14.

Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Sentiment analysis may offer insights into patient outcomes through the subjective expressions made by clinicians in the text of encounter notes. We analyzed the predictive, concurrent, convergent, and content validity of six sentiment methods in a sample of 793,725 multidisciplinary clinical notes among 41,283 hospitalizations associated with an intensive care unit stay. None of these approaches improved early prediction of in-hospital mortality using logistic regression models, but did improve both discrimination and calibration when using random forests. Read More

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December 2018

Understanding the transition from water to land: Insights from multi-omic analyses of the perivitelline fluid of apple snail eggs.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, Hong Kong Baptist University, Hong Kong, China; HKBU Institute of Research and Continuing Education, Shenzhen, China. Electronic address:

Most gastropods deposit their eggs either on land or underwater, but the family Ampullariidae includes members that exhibit both underwater and aerial oviposition, making it an ideal model for understanding mechanisms underlying the evolutionary transition from water to land. We applied SDS-PAGE and LC-MS/MS to analyse the proteome of the egg perivitelline fluid (PVF) of Marisa cornuarietis - an aquatic ovipositing ampullariid. Comparison with the reported PVF proteomes of two aerial ovipositing ampullariids (Pomacea canaliculata and P. Read More

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December 2018

Comprehensive identification of protein disulfide bonds with pepsin/trypsin digestion, Orbitrap HCD and Spectrum Identification Machine.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Center for Advanced Proteomics Research and Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School and Cancer Institute of New Jersey, Newark, NJ 07103, USA. Electronic address:

Disulfide bonds (SS) are post-translational modifications important for the proper folding and stabilization of many cellular proteins with therapeutic uses, including antibodies and other biologics. With budding advances of biologics and biosimilars, there is a mounting need for a robust method for accurate identification of SS. Even though several mass spectrometry methods have emerged for this task, their practical use rests on the broad effectiveness of both sample preparation methods and bioinformatics tools. Read More

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December 2018

The Acute Influence of Acid Suppression with Esomeprazole on Gastrointestinal Microbiota and Brain Gene Expression Profiles in a Murine Model of Restraint Stress.

Neuroscience 2018 Dec 14. Epub 2018 Dec 14.

Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, B168 12700 E. 19th Avenue, Aurora, CO 80045, USA. Electronic address:

The central nervous system (CNS) and gastrointestinal tract (GIT) are linked through neuro-endocrine and humoral pathways. Critically ill patients suffer severe physical and emotional stress and frequently receive acid suppressants; however, stress and acid suppression may alter GIT microbiota. This study evaluated the effects of acid suppression on the GIT microbiota and genome-wide expression of brain-specific genes in a murine model of restraint stress. Read More

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December 2018

Mechanisms of poor oral bioavailability of flavonoid Morin in rats: From physicochemical to biopharmaceutical evaluations.

Eur J Pharm Sci 2018 Dec 14. Epub 2018 Dec 14.

School of Pharmaceutical Sciences, Zhengzhou University, No.100. Kexue Road, Zhengzhou, Henan Province 450001, China; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China. Electronic address:

We recently reported that the absolute oral bioavailability of flavonoid Morin was extremely low at 0.45%, resulting in unsatisfied therapeutic efficacy in vivo. The present study was aimed to systemically assess the pre-absorption risks of Morin for rationale formulation design. Read More

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December 2018

Nicotine protects against manganese and iron-induced toxicity in SH-SY5Y cells: Implication for Parkinson's disease.

Neurochem Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA. Electronic address:

Manganese (Mn) and iron (Fe) are trace elements that are essential for proper growth and physiological functions as both play critical role in a variety of enzymatic reactions. At high concentrations, however, they can be toxic and cause neurodegenerative disorders, particularly Parkinson-like syndromes. Nicotine, on the other hand, has been shown to have neuroprotective effects against various endogenous or exogenous toxins that selectively damage the dopaminergic cells. Read More

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December 2018

Direct antimicrobial susceptibility tests of bacteria and yeasts from positive blood cultures by using serum separator gel tubes and MALDI-TOF MS.

J Microbiol Methods 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, China. Electronic address:

Early and appropriate antimicrobial treatment can effectively reduce the mortality rate caused by bloodstream infections (BSIs) and is critical for favorable patient outcomes. In general, >90% of positive blood cultures will show positive results within 48 h after incubation in the BACTECTM FX system. However, an additional 6-8 h are required to obtain clones of the bacterium and another 10-24 h to obtain antimicrobial susceptibility test (AST) results. Read More

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December 2018

Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.

Antiviral Res 2018 Dec 14. Epub 2018 Dec 14.

Aix-Marseille Université, CNRS UMR 7257, Architecture et Fonction des Macromolécules Biologiques, 163 avenue de Luminy, 13288, Marseille, France. Electronic address:

Arenaviridae is a viral family whose members are associated with rodent-transmitted infections to humans responsible of severe diseases. The current lack of a vaccine and limited therapeutic options make the development of efficacious drugs of high priority. The cap-snatching mechanism of transcription of Arenavirus performed by the endonuclease domain of the L-protein is unique and essential, so we developed a drug design program targeting the endonuclease activity of the prototypic Lymphocytic ChorioMeningitis Virus. Read More

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December 2018

Exploration of sexual dimorphism and inter-individual variability in multivariate parameter spaces for a pharmacokinetic compartment model.

Math Biosci 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854; Department of Biomedical Engineering, Rutgers The State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854. Electronic address:

Pharmacokinetic models are particularly useful to study the underlying and complex physiological mechanisms contributing to clinical differences across patient subgroups or special populations. Unfortunately, the inherent variability of biological systems and knowledge gaps in physiological data limit confidence in model predictions for special populations. Sourcing data to reflect the desired physiologies can be resource intensive, particularly for a larger model. Read More

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December 2018

Variation in Implementation and Outcomes of Early Extubation Practices After Infant Cardiac Surgery.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Michigan Medicine C.S. Mott Children's Hospital, Department of Pediatrics, 1540 E. Hospital Drive, Ann Arbor, MI 48109.

Background: The Pediatric Heart Network Collaborative Learning Study (PHN CLS) increased early extubation after infant Tetralogy of Fallot (TOF) and coarctation repair overall at participating sites through implementing a clinical practice guideline (CPG). We evaluated variability across sites in CPG implementation and outcomes.

Methods: Patient characteristics and outcomes [time to extubation, length of stay (LOS)] were compared across sites, including pre- to post-CPG changes. Read More

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December 2018
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Disconnect between Fibrotic Response and Right Ventricular Dysfunction.

Am J Respir Crit Care Med 2018 Dec 17. Epub 2018 Dec 17.

Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria ;

Rationale: Remodeling and fibrosis of the right ventricle (RV) may cause RV dysfunction and poor survival in patients with pulmonary hypertension (PH).

Objectives: To investigate the consequences of RV fibrosis modulation and the accompanying cellular changes on RV function.

Methods: Expression of fibrotic markers was assessed in the RV of PH patients, the murine pulmonary artery banding (PAB)-, and rat monocrotaline-, and Sugen5416/hypoxia models. Read More

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December 2018

An Approach for Guiding the Development and Assessing the Interdisciplinarity of New Methodologies for Community Disaster Resilience.

Authors:
Elaina J Sutley

Risk Anal 2018 Dec 17. Epub 2018 Dec 17.

There are critical and preventable inequalities in disaster impacts and postdisaster recovery. To formulate solutions for minimizing or preventing these unequal impacts, there is a great need for interdisciplinary methodologies that use social factors to set project scopes and drive engineering analyses and designs. At present time, however, limited guidance exists on how to develop and execute interdisciplinary methodologies, especially related to the study of community disaster resilience. Read More

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December 2018

Admission Pentraxin-3 Level Predicts Severity of Community-Acquired Pneumonia Independently of Etiology.

Proteomics Clin Appl 2018 Dec 17:e1800117. Epub 2018 Dec 17.

Department of Respiratory & Critical Care Medicine, Peking University People's Hospital, Beijing, People's Republic of China.

Purpose: Timely and accurate triaging of patients with community-acquired pneumonia (CAP) is difficult for clinicians. Pentraxin-3 (PTX3) is a non-specific marker of disease severity; however, PTX3 data from CAP patients are lacking.

Experimental Design: An observational, prospective study of CAP patients was conducted in 2016. Read More

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December 2018

Diel versus time-integrated (daily) photosynthesis and irradiance relationships of coral reef organisms and communities.

PLoS One 2018 17;13(12):e0208607. Epub 2018 Dec 17.

Coral Reef Ecology and Optics Laboratory (CREOL), Bermuda Institute of Ocean Sciences (BIOS), St. George's, Bermuda.

The most important source of energy to tropical shallow water coral reefs is light, the transformation of which ultimately limits reef biomass and growth. Therefore, measurements of productivity (primary production, P) for benthic reef organisms and communities are critical to understand reef functioning. Short-term (minutes to hours) P measurements of reef photosynthesizers virtually always produce the classic hyperbolic tangent (or similar) P-E (irradiance) relationship, with P rapidly rising to a saturation point as E increases. Read More

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December 2018

The adjuvant AlhydroGel elicits higher antibody titres than AddaVax when combined with HIV-1 subtype C gp140 from CAP256.

PLoS One 2018 17;13(12):e0208310. Epub 2018 Dec 17.

Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa.

With the HIV-1 epidemic in southern Africa still rising, a prophylactic vaccine against the region's most prolific subtype (subtype C) would be a significant step forward. In this paper we report on the effect of 2 different adjuvants, AddaVax and AlhydroGel, formulated with HIV-1 subtype C gp140, on the development of binding and neutralising antibody titres in rabbits. AddaVax is a squalene-based oil-in-water nano-emulsion (similar to MF59) which can enhance both cellular and humoral immune responses, whilst AlhydroGel (aluminium hydroxide gel) mainly drives a Th2 response. Read More

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December 2018

Assessment of the ergonomic risk from saddle and conventional seats in dentistry: A systematic review and meta-analysis.

PLoS One 2018 17;13(12):e0208900. Epub 2018 Dec 17.

Department of Community Dentistry, School of Dentistry of Piracicaba, University of Campinas, Piracicaba, SP, Brazil.

Objective: This study aimed to verify whether the saddle seat provides lower ergonomic risk than conventional seats in dentistry.

Methods: This review followed the PRISMA statement and a protocol was created and registered in PROSPERO (CRD42017074918). Six electronic databases were searched as primary study sources. Read More

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December 2018

Health seeking for chronic lung disease in central Malawi: Adapting existing models using insights from a qualitative study.

PLoS One 2018 17;13(12):e0208188. Epub 2018 Dec 17.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.

Background: Chronic lung diseases contribute to the growing non-communicable disease (NCD) burden and are increasing, particularly in many low and middle-income countries (LMIC) in sub-Saharan African. Early engagement with health systems in chronic lung disease management is critical to maintain quality of life and prevent further damage. Our study sought to understand health seeking behaviour in relation to chronic lung disease and TB in a rural district in Malawi. Read More

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December 2018
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Evolution of maternal and zygotic mRNA complements in the early Drosophila embryo.

PLoS Genet 2018 Dec 17;14(12):e1007838. Epub 2018 Dec 17.

Department of Evolution and Ecology, University of California, Davis, Davis, California, United States of America.

The earliest stage of animal development is controlled by maternally deposited mRNA transcripts and proteins. Once the zygote is able to transcribe its own genome, maternal transcripts are degraded, in a tightly regulated process known as the maternal to zygotic transition (MZT). While this process has been well-studied within model species, we have little knowledge of how the pools of maternal and zygotic transcripts evolve. Read More

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December 2018
1 Read

Respiratory Deterioration and Cardiac Arrest.

Crit Care Med 2019 Jan;47(1):e71-e72

Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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January 2019

The authors reply.

Crit Care Med 2019 Jan;47(1):e69-e70

Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada, Division of Critical Care Medicine, Department of Medicine, University Health Network, Toronto, ON, Canada, and Department of Critical Care Medicine, Sunnybrook Health Sciences Center, Toronto, ON, Canada Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada, Department of Critical Care Medicine, Sunnybrook Health Sciences Center, Toronto, ON, Canada, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, and Department of Surgery, Sunnybrook Health Sciences Center and the University of Toronto, Toronto, ON, Canada.

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January 2019

The author replies.

Authors:
Selena S Au

Crit Care Med 2019 Jan;47(1):e68

Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada.

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January 2019

Routine Preoperative Intra-Aortic Balloon Pump: Shooting in the Dark.

Authors:
Ajay Kumar Jha

Crit Care Med 2019 Jan;47(1):e66

Department of Anesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

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January 2019

Grading the GRADE-Critical Care Community and Trustworthy Guidelines.

Crit Care Med 2019 Jan;47(1):142-144

Department of Medicine; and Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada Department of Medicine, McMaster University;, Department of Health Research Methods, Evidence, and Impact, McMaster University; and Population Health Research Institute, Hamilton, ON, Canada Department of Medicine; and Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

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January 2019

Should We Agree to Disagree on Who May Benefit From ICU Admission?

Crit Care Med 2019 Jan;47(1):133-135

Center for Healthcare Delivery Science; and Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA The Pulmonary Center, and Evans Center for Implementation and Improvement Sciences, Department of Medicine, Boston University School of Medicine; and Department of Health Law, Policy and Management, Boston University School of Public Health, Boston, MA.

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January 2019

Practice, But Verify: A Novel Method to Assess Compliance With Lung Protective Ventilation Using Electronic Health Record Data.

Crit Care Med 2019 Jan;47(1):131-133

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.

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January 2019

Assessment of Pulmonary Arterial Pressure Using Critical Care Echocardiography: Dealing With the Yin and the Yang?

Authors:
Philippe Vignon

Crit Care Med 2019 Jan;47(1):126-128

Medical-Surgical Intensive Care Unit, and Inserm CIC 1435, Dupuytren Teaching Hospital; and University of Limoges, Limoges, France.

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January 2019

Extracorporeal CO2 Removal-A Solution in Search of a Problem?

Authors:
Eddy Fan

Crit Care Med 2019 Jan;47(1):124-126

Interdepartmental Division of Critical Care Medicine and the Institute of Health Policy, Management and Evaluation, University of Toronto; and Department of Medicine, University Health Network, Toronto, ON, Canada.

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January 2019

Welsh Study Puts ICU Survival on the Map.

Authors:
David M Maslove

Crit Care Med 2019 Jan;47(1):121-122

Department of Critical Care Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, ON, Canada.

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January 2019

Causal Inference From Observational Data: New Guidance From Pulmonary, Critical Care, and Sleep Journals.

Crit Care Med 2019 Jan;47(1):1-2

Department of Critical Care Medicine, Queen's University and Kingston Health Sciences Center, Kingston, ON, Canada Icahn School of Medicine at Mount Sinai, New York, NY.

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January 2019

Tissue Acquisition During EBUS-TBNA: Comparison of Cell Blocks Obtained From a 19G Versus 21G Needle.

J Bronchology Interv Pulmonol 2018 Dec 14. Epub 2018 Dec 14.

Division of Pulmonary and Critical Care Medicine.

Background: Previous studies have shown that needle gauge size has no significant impact on diagnostic yield during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Our objective was to determine whether cell blocks obtained via the new Flex 19G EBUS-TBNA needle would contain more cellular material based on cell area compared with those obtained from a 21G needle.

Methods: A prospective analysis of patients undergoing EBUS-TBNA at our institutions was performed. Read More

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December 2018

Graduating Fellows' Procedural Comfort Level With Pulmonary Critical Care Procedures.

J Bronchology Interv Pulmonol 2018 Dec 14. Epub 2018 Dec 14.

Division of Pulmonary, Allergy & Critical Care, University of Massachusetts Medical School, Worcester, MA.

Background: Graduating fellows from pulmonary and critical care programs are expected to independently perform bronchoscopy and common medical procedures in the intensive care unit. Given variable exposure and learning opportunities at different training programs, little is known about how comfortable graduating fellows are with these procedures.

Methods: A survey concerning the ACGME required procedures for pulmonary and critical care fellowship was sent to graduating fellows and program directors at all ACGME accredited subspecialty fellowship programs in pulmonary, critical care, and combined pulmonary critical care medicine. Read More

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December 2018

Monitoring Nonlinear Dynamics of Change in a Single Case of Psychodynamic Play Therapy.

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):113-135

Sapienza University of Rome, Italy and NCU Italian University, London, UK.

A systematic single case study with a mixed quantitative and qualitative methodology was conducted to investigate the nonlinear dynamics of change in play profiles of a child in psychodynamic play therapy. The first aim of the study was to cluster the different features of play characteristics (i.e. Read More

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January 2019
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From poison to drug: new recipes discovered containing colchicine as a remedy for Podagra in Rome and Byzantium.

Clin Exp Rheumatol 2018 Nov 19. Epub 2018 Nov 19.

Institute of the History, Philosophy and Ethics of Medicine, Ulm University, Germany.

Objectives: In Antiquity, colchicine was used as a poison and as a remedy for Podagra. Research so far has revealed that the physician Alexander of Tralles was the first who used it in the 6th century AD. Alexander recommended a plant he called "Hermodaktylon", which takes off the pain in the feet immediately. Read More

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November 2018
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