769,438 results match your criteria Critical Reviews in Microbiology [Journal]
Chemosphere 2018 Dec 4;219:567-573. Epub 2018 Dec 4.
Departmentof Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA. Electronic address:
Background: Humans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust. Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment.
Objectives: To quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs. Read More
Clin Neurol Neurosurg 2018 Dec 6;176:97-102. Epub 2018 Dec 6.
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 37 Guoxue Rd, Chengdu, 610041, China. Electronic address:
Objective: Structural changes of the spine and chest wall associated with SRS result in poor cardiopulmonary function. Comprehensive assessment of pulmonary function is extremely important for patients with SRS before a correction operation. We explore the changes of distribution of lung ventilation and perfusion function in patients with SRS using SPECT/CT and describe the relation between these changes with Cobb angle and FVC%. Read More
J Mol Graph Model 2018 Dec 7;87:185-191. Epub 2018 Dec 7.
Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
The emergence of antibiotic resistance has attracted the attention of scientists and scientific circles over the decades. β-Lactam antibiotics resistance is a worldwide therapeutic challenge in bacterial infections, mediated through several mechanisms of which mutations in Penicillin Binding Proteins (PBPs) are an important issue, making critical therapeutic problems in the human population. Accordingly, investigating the dynamic structures of mutant variants could result in a profound understanding of such a specific resistance. Read More
Plant Physiol Biochem 2018 Dec 7;135:167-173. Epub 2018 Dec 7.
Shandong Provincial Key Laboratory of Plant Stress, College of Life Sciences, Shandong Normal University, Jinan, 250014, China. Electronic address:
Chilling stress is a critical environmental factor that limits plant growth, yield and distribution. Maize (Zea mays L.) is an important food and forage crop, and industrial raw material, in China. Read More
J Proteomics 2018 Dec 12. Epub 2018 Dec 12.
Proteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain; Department of Medicine and General Cytometry Service-Nucleus, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain. Electronic address:
Understanding the dynamic of the proteome is a critical challenge because it requires high sensitive methodologies in high-throughput formats in order to decipher its modifications and complexity. While molecular biology provides relevant information about cell physiology that may be reflected in post-translational changes, High-Throughput (HT) experimental proteomic techniques are essential to provide valuable functional information of the proteins, peptides and the interconnections between them. Hence, many methodological developments and innovations have been reported during the last decade. Read More
Child Abuse Negl 2018 Dec 12;88:288-297. Epub 2018 Dec 12.
Research Center for Child Development, College of Elementary Education, Capital Normal University, No.105 Xisan Huan Beilu, Beijing, 100048, China. Electronic address:
Background: To date whether the effects of parental corporal punishment (CP) on executive function (EF) distinct components are different is less clear. Moreover, theory and empirical work suggest that physiological regulation system may help to explain the individual differences in the developmental outcomes associated with parental CP.
Objective: This study examined the effects of parental CP on Chinese preschoolers' EF and whether the cortisol stress reactivity would moderate such effects. Read More
Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.
State Key Laboratory of Biotherapy and Cancer Center and Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China. Electronic address:
Tannic acid, a hydrolysable tannin, exists commonly in food plants. Tannic acid has already been shown various anticancer mechanisms such as inhibiting the proliferation, inducing a higher apoptotic rate and slowing down the metastasis of different cancers. Moreover, tannic acid was reported to reduce the side effects caused by chemotherapeutics on patients. Read More
Neuroimage 2018 Dec 12. Epub 2018 Dec 12.
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351, South Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, South Korea; Animal Research and Molecular Imaging, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea; Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea. Electronic address:
Neuroplasticity is considered essential for recovery from brain injury in developing brains. Recent studies indicate that it is especially effective during early postnatal development and during the critical period. The current study used functional magnetic resonance imaging (fMRI) and local field potential (LFP) electrophysiological recordings in rats that experienced neonatal hypoxic-ischemic (HI) injury during the critical period to demonstrate that physical exercise (PE) can improve cortical plasticity even when performed during adulthood, after the critical period. Read More
Neurobiol Learn Mem 2018 Dec 12. Epub 2018 Dec 12.
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Background: Sleep facilitates the extraction of semantic regularities amongst newly encoded memories, which may also lead to increased false memories. We investigated sleep stage proportions and sleep spindles in the recollection of adolescents' false memories, and their potential sex-specific differences.
Methods: 196 adolescents (mean age 16. Read More
Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.
Department of Pharmaceutics, Rutgers University, Piscataway, NJ 08854, USA; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:
Nowadays twin-screw granulation has been emerging as an attractive continuous wet granulation technique. This study was geared towards better process design and understanding with emphasis on bridging the knowledge gap between input and output variables by employing sequential experimentation strategy. A low-dose formulation for granulation experiments contained anhydrous caffeine as the model drug. Read More
Cell Signal 2018 Dec 12. Epub 2018 Dec 12.
Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China. Electronic address:
Human Glioblastoma is one deadly disease; the median survival time is reported to be 13.9 months after treatment. In the present study, we discovered that DHX33 is highly expressed in 84% of all Glioblastoma multiforme (GBM). Read More
Ann Allergy Asthma Immunol 2018 Dec 12. Epub 2018 Dec 12.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Toxicology 2018 Dec 12. Epub 2018 Dec 12.
Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (formerly known as Kinki University), Higashi-Osaka, 577-8802, Japan. Electronic address:
Bortezomib, a first-line agent for treatment of multiple myeloma, exhibits anticancer activity through proteasome inhibition. However, bortezomib-induced peripheral neuropathy (BIPN) is one of the most serious side effects. Since decreased proteasomal degradation of Ca3. Read More
Biol Psychol 2018 Dec 12. Epub 2018 Dec 12.
Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27514, USA; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27514, USA. Electronic address:
Accumulating evidence suggests that autism spectrum disorder (ASD) may be conceptualized within a framework of reward processing impairments. The "Social Motivation Theory of Autism" posits that reduced motivation to interact with people and decreased pleasure derived from social interactions may derail typical social development and contribute to the emergence of core social communication deficits in ASD. Neuroinflammation may disrupt the development of mesolimbic dopaminergic systems that are critical for optimal functioning of social reward processing systems. Read More
Adv Drug Deliv Rev 2018 Dec 12. Epub 2018 Dec 12.
MedImmune, Gaithersburg, MD 20878, United States. Electronic address:
CD40 is a TNF receptor superfamily member expressed on both immune and non-immune cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies. Non-hematopoietic cells expressing CD40 can also engage CD40L and trigger a pro-inflammatory response. Read More
Microvasc Res 2018 Dec 12. Epub 2018 Dec 12.
Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarão, SC, Brazil. Electronic address:
Background: The choroid plexus (CP), main component of blood-cerebrospinal fluid barrier (BCSFB), protects the brain from peripheral inflammation similar to the blood-brain barrier. Thus, CP is considered a critical target site of oxidative damage, which in sepsis oxidative stress is likely to be a major step in the development of brain damage. Functional alterations in CP may be associated with sepsis-induced brain injury. Read More
Eur J Pharmacol 2018 Dec 12. Epub 2018 Dec 12.
Centre National de la Recherche Scientifique and University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 67000 Strasbourg, France. Electronic address:
Inflammatory processes are critical promoting factors of chronic pain states, mostly by inducing peripheral and central sensitization of the nociceptive system. These processes are associated with a massive increase in glutamatergic transmission, sometimes facilitated by spinal disinhibition. In this study, we used etifoxine, a non-benzodiazepine anxiolytic known to amplify inhibition mediated by gamma-aminobutyric acid type A (GABA) receptors in pain processing regions, either directly (through allosteric modulation) or indirectly (through the synthesis of endogenous neurosteroids). Read More
Acta Trop 2018 Dec 12. Epub 2018 Dec 12.
Centro Internacional de Entrenamiento e Investigaciones Médicas CIDEIM, Carrera 125 N 19-225, Cali, Colombia; Universidad ICESI, Cali,Colombia. Electronic address:
In Colombia Aedes (Stegomyia) aegypti is the main vector of urban arboviruses such as dengue, chikungunya and Zika. This urban mosquito has a well-established capacity to develop insecticide resistance to different types of insecticides (pyrethroids, organochlorides, organophosphates), using multiple resistance mechanisms. An understanding of ongoing resistance mechanisms is critical to determining the activities of vector control programs. Read More
Horm Behav 2018 Dec 12. Epub 2018 Dec 12.
UCLA DGSOM Dept of Neurobiology, 650 Charles E Young Dr. S, Los Angeles, CA 90095, Laboratory of Neuroendocrinology of the Brain Research Institute, United States of America.
In females, a hallmark of puberty is the luteinizing hormone (LH) surge that triggers ovulation. Puberty initiates estrogen positive feedback onto hypothalamic circuits, which underlie the stimulation of gonadotropin releasing hormone (GnRH) neurons. In reproductively mature female rodents, both estradiol (E2) and progesterone (P4) signaling are necessary to stimulate the surge release of GnRH and LH. Read More
Chest 2018 Dec 12. Epub 2018 Dec 12.
Trauma, Critical Care and Surgery, Carolinas Medical Center, Charlotte, NC 28203.
Percutaneous dilatational tracheotomy (PDT) has become increasingly popular and gained widespread acceptance. The modern PDT procedure has also evolved to whereby it can be safely performed by surgeons and non-surgeons in the intensive care unit (ICU). Moreover, bedside PDT has proven clinical outcomes and can save hospital resources. Read More
Clin Biochem 2018 Dec 12. Epub 2018 Dec 12.
RCPA Quality Assurance Programs, St Leonards, Sydney, NSW, Australia 2065. Electronic address:
Background: To minimise the risk of patient harm from results, laboratories should establish QC strategies and monitor the performance of assays in line with the analytical and clinical risk.
Methods: Steady state errors were calculated from a distribution normalized for an Analytical Performance Specification expressed as Assay Capability (imprecision) minus Assay Stability (drift). Inverting this error rate gave QC run length containing one error. Read More
Swiss Med Wkly 2018 Nov 2;148:w14688. Epub 2018 Dec 2.
Health Ethics and Policy Lab, Department of Health Sciences and Technology, ETH Zurich, Switzerland.
Dual use research of concern (DURC) is defined by the World Health Organization as "life sciences research that is intended for benefit, but which might easily be misapplied to do harm." Ethical and policy discussions on DURC span the past three decades. Today, however, new and emerging technologies and associated sociocultural transformations within the scientific community are reshaping the current risk scenario. Read More
Swiss Med Wkly 2018 Dec 15;148:w14691. Epub 2018 Dec 15.
Lung Centre, Cantonal Hospital St Gallen, Switzerland.
Aim: Our aim was to estimate the diagnostic performance of institutions and healthcare regions from a nationwide hospitalisation database.
Methods: The Shannon diversity index was used as an indicator of diagnostic performance based on the International Classification of Disease, 10th revision, German Modification (ICD-10-GM codes). The dataset included a total of 9,325,326 hospitalisation cases from 2009 to 2015 and was provided by the Swiss Federal Office for Statistics. Read More
Glob Chang Biol 2018 Dec 15. Epub 2018 Dec 15.
Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, China.
It is critical to accurately estimate carbon (C) turnover time as it dominates the uncertainty in ecosystem C sinks and their response to future climate change. In the absence of direct observations of ecosystem C losses, C turnover times are commonly estimated under the steady-state assumption (SSA), which has been applied across a large range of temporal and spatial scales including many at which the validity of the assumption is likely to be violated. However the errors associated with improperly applying SSA to estimate C turnover time and its covariance with climate as well as ecosystem C sequestrations have yet to be fully quantified. Read More
Immunology 2018 Dec 15. Epub 2018 Dec 15.
William Harvey Research Institute, Barts and the London, Queen Mary University of London, London, UK.
Healthy white adipose tissue (WAT) participates in regulating systemic metabolism, whilst dysfunctional WAT plays a prominent role in the development of obesity-associated comorbidities. Tissue resident immune cells are important for maintaining WAT homeostasis, including conventional dendritic cells (cDCs) which are critical in the initiation and regulation of adaptive immune responses. Due to phenotypic overlap with other myeloid cells, the distinct contribution of WAT cDCs has been poorly understood. Read More
J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.
Nursing Research and Practice Development, Ulster University, and South Eastern Health and Social Care Trust, Northern Ireland.
Aims And Objectives: To review published research into the staff and adult patient experience of person-centred practice in a 100% single-room environment in acute care.
Background: There has been a significant move towards the 100% single-room environment within healthcare systems. Furthermore, there has been a global move for developing person-centred practice in a range of healthcare settings. Read More
Plant J 2018 Dec 15. Epub 2018 Dec 15.
Center for Crop Disease and Insect Pests, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, China.
The extrahaustorial membrane (EHM) is a host-derived interfacial membrane encasing the haustorium of powdery mildew fungi. The Arabidopsis thaliana RESISTANCE TO POWDERY MILDEW 8.2 (RPW8. Read More
Plant J 2018 Dec 15. Epub 2018 Dec 15.
Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Countryside, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
The transition to tuberization contributes greatly to the adaptability of potato to a wide range of environments. Phytochromes are important light receptors for the growth and development of plants, but the detailed functions of Phytochromes remain unclear in potato. In this study, we first confirmed that phytochrome F (StPHYF) played essential roles in photoperiodic tuberization in potato. Read More
Biotechnol Bioeng 2018 Dec 15. Epub 2018 Dec 15.
Merck Life Sciences, Upstream R&D, Frankfurter Strasse 250, Darmstadt, Germany.
Glycosylation is a key critical quality attribute for monoclonal antibodies and other recombinant proteins because of its impact on effector mechanisms and half-life. In this study, a variety of compounds were evaluated for their ability to modulate glycosylation profiles of recombinant monoclonal antibodies produced in Chinese hamster ovary cells. Compounds were supplemented into the cell culture feed of fed-batch experiments performed with a CHO K1 and a CHO DG44 cell line expressing a recombinant IgG1. Read More
Med Sci Monit 2018 Dec 15;24:9102-9109. Epub 2018 Dec 15.
Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China (mainland).
BACKGROUND The design and harvest of the anterolateral thigh (ALT) multi-paddled flap is a critical step in reconstructive surgeries. However, limited perforator distribution patterns of traditional design methods have gradually emerged in clinical practice. The aim of this study was to investigate the effect of a new technique (the 3-5 system) on ALT multi-paddled flap design. Read More
J Appl Clin Med Phys 2018 Dec 14. Epub 2018 Dec 14.
Joint Department of Physics, The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, London, UK.
Current clinical practice is to prescribe to 95% of the planning target volume (PTV) in 4D stereotactic body radiotherapy (SBRT) for lung. Frequently the PTV margin has a very low physical density so that the internal target volume (ITV) receives an unnecessarily high dose. This study investigates the alternative of prescribing to the ITV while including the effects of positional uncertainties. Read More
J Nurs Scholarsh 2018 Dec 15. Epub 2018 Dec 15.
Rho, Professor, University of Michigan School of Nursing, Ann Arbor, MI, USA.
Purpose: The purposes of this study were to (a) describe nurse manager (NM) leadership behaviors for evidence-based practice, NM evidence-based practice competencies, and unit climates for evidence-based practice implementation in acute care, and (b) test for differences in NMs' and staff nurses' (RNs') perceptions.
Design: A multisite cross-sectional design was used to collect data from a sample of 24 NMs and 553 RNs from 24 adult medical-surgical units in seven U.S. Read More
J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.
Department of Clinical Institute, University of Southern, Denmark.
Aim And Objectives: To explore Parents' experiences of donation to their child before kidney transplantation.
Background: Transplantation is the treatment of choice for pediatric patients with end-stage renal disease. Living donor kidney transplantation has shown a higher long-term transplant survival compared to deceased donor transplantation and entails a more controllable process, with shorter waiting time. Read More
J Med Virol 2018 Dec 14. Epub 2018 Dec 14.
Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
During the natural history of chronic hepatitis B infection (CHB) the function of B cells is still obscure. Several limited studies have suggested that B cells are highly active in CHB patients. In present work, we reported that the 4-1BB ligand (4-1BBL) expression on B cells was significantly higher in CHB patients than that in healthy subjects, meanwhile the CHB patients had higher serological IgG levels. Read More
Hepatology 2018 Dec 14. Epub 2018 Dec 14.
UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA.
Acetaminophen (APAP) overdose is one of the leading causes of hepatotoxicity and acute liver failure in the United States. Accumulating evidence suggests that hepatocyte necrosis plays a critical role in APAP-induced liver injury. However, the mechanisms of APAP-induced necrosis and liver injury are not fully understood. Read More
J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) have been found to be important for the airway remodeling during the pathogenesis of asthma. Salidroside a bioactive glucoside that exerts antitumor activity via inhibiting the cell proliferation and migration of cancer cells. The aim of the current study was to evaluate the effects of salidroside on the proliferation and migration of ASMCs. Read More
Am J Community Psychol 2018 Dec 14. Epub 2018 Dec 14.
Pacifica Graduate Institute, Carpinteria, CA, USA.
Community psychology's history has traditionally been described within the context of U.S. history, silencing contributions from people of color from the Americas, Asia, the Pacific Islands, and Africa. Read More
Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.
Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, India.
Process analytical technology is gaining interest in the biopharmaceutical industry as a means to enable consistency in processing and thereby in product quality via process control. Protein refolding is known to be significantly impacted by critical process parameters and feed material attributes including composition and pH of the solubilization and refolding buffers. Hence, in order to achieve robust process control and product quality, these attributes and parameters need to be monitored. Read More
Cancer Treat Res 2019 ;171:75-92
University of Colorado Denver, Denver, CO, USA.
Drug shortages pose a significant public health concern in the United States, and cancer drugs are among those most affected. Shortages present serious safety risks for patients and substantial burden on providers and the healthcare system. Multifaceted drivers of this complex problem include manufacturing disruptions, raw material shortages, regulatory issues, market dynamics, and limited financial incentives that reward quality and production of off-patent drugs. Read More
Pharmacoecon Open 2018 Dec 14. Epub 2018 Dec 14.
King's College Hospital National Health Service Foundation Trust, London, UK.
Background: Uncertainty within cost-effectiveness analysis, often driven by lack of mature data from large clinical trials, plays a key role in decisions made by the National Institute for Health and Care Excellence (NICE), particularly for early access medicines and orphan drugs.
Objectives: In this case study, we used real-world evidence to address the uncertainty in the cost-effectiveness case for lenalidomide in transfusion-dependent low- and intermediate-1-risk myelodysplastic syndrome (MDS) deletion 5q [del(5q)], affecting a small but unique subpopulation with an orphan disease.
Methods: As part of a submission to NICE, we developed a cost-effectiveness model for lenalidomide, resulting in eventual recommendation. Read More
Hum Nat 2018 Dec 14. Epub 2018 Dec 14.
Department of Anthropology, Dartmouth College, Hanover, NH, 03755, USA.
Identifying the determinants of reproductive success in small-scale societies is critical for understanding how natural selection has shaped human evolution and behavior. The available evidence suggests that status-accruing behaviors such as hunting and prosociality are pathways to reproductive success, but social egalitarianism may diminish this pathway. Here we introduce a mixed longitudinal/cross-sectional dataset based on 45 years of research with the Batek, a population of egalitarian rain forest hunter-gatherers in Peninsular Malaysia, and use it to test the effects of four predictors of lifetime reproductive success: (i) foraging return rate, (ii) sharing proclivity, (iii) cooperative foraging tendency, and (iv) kin presence. Read More
Mol Divers 2018 Dec 14. Epub 2018 Dec 14.
Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.
5-Amino-pyrazoles have proven to be a class of fascinating and privileged organic tools for the construction of diverse heterocyclic or fused heterocyclic scaffolds. This review presents comprehensively the applications of 5-amino-pyrazoles as versatile synthetic building blocks in the synthesis of remarkable organic molecules with an emphasis on versatile functionalities. Following a brief introduction of synthesis methods, planning strategies to construct organic compounds, particularly diverse heterocyclic scaffolds, such as poly-substituted heterocyclic compounds and fused heterocyclic compounds via 5-amino-pyrazoles, have been summarized. Read More
J Clin Monit Comput 2018 Dec 14. Epub 2018 Dec 14.
Department Anaesthesia and Intensive Care Units, Humanitas Research Hospital, Humanitas University, Milan, Italy.
To compare the effective arterial elastance (Ea) obtained from the arterial pressure with Ea calculated from left-ventricular (LV) pressure-volume analysis. Experimental study. LV pressure-volume data was obtained with a conductance catheter and arterial pressures were measured via a fluid-filled catheter placed in the proximal aorta, femoral and radial arteries. Read More
Clin Res Cardiol 2018 Dec 14. Epub 2018 Dec 14.
Division of Adult Congenital and Valvular Heart Disease, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
Background: Current trials and registries of transcatheter valve implantation (TAVI) mostly include patients older than 75 years. Little is known about younger patients who undergo this treatment. We investigated comorbidities among patients < 75 years old who underwent TAVI in the SAPIEN 3™ European post-approval SOURCE 3 Registry, and analysed outcomes at 30 days and 1 year. Read More
Lung 2018 Dec 14. Epub 2018 Dec 14.
Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA.
Med Klin Intensivmed Notfmed 2018 Dec 14. Epub 2018 Dec 14.
Klinik für Anästhesiologie, Anästhesie, Intensiv‑, Notfall- und Schmerzmedizin, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Deutschland.
The shortage of donor organs has not improved in recent years. To increase the number and success of transplantation it is crucial to optimize the processes of early identification of potential organ donors and structured critical care management. The therapy starts long before brain death is diagnosed. Read More
Eur J Hum Genet 2018 Dec 14. Epub 2018 Dec 14.
CHU Lille, Clinique de Génétique, 59000, Lille, France.
Holt-Oram syndrome (HOS) is an autosomal dominant condition characterised by the association of congenital heart defect (CHD), with or without rhythm disturbances and radial defects, due to TBX5 variants. The diagnosis is challenged by the variability of expression and the large phenotypic overlap with other conditions, like Okihiro syndrome, TAR syndrome or Fanconi disease. We retrospectively reviewed 212 patients referred for suspicion of HOS between 2002 and 2014, who underwent TBX5 screening. Read More
Neuropsychopharmacology 2018 Dec 14. Epub 2018 Dec 14.
Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Drug abuse is a multifaceted disorder that involves maladaptive decision making. Long-lasting changes in the addicted brain are mediated by a complex circuit of brain reward regions. The prefrontal cortex (PFC) is one region in which chronic drug exposure changes expression and function of upstream transcriptional regulators to alter drug responses and aspects of the addicted phenotype. Read More
Nat Commun 2018 Dec 14;9(1):5331. Epub 2018 Dec 14.
Posttranscriptional Gene Regulation, Cancer Research and Experimental Haemostasis, University Medical Centre Mainz, Mainz, 55131, Germany.
Diversification at the transcriptome 3'end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and dedifferentiation processes. Here, we identify extensive transcriptome 3'end-alterations in neuroblastoma, a tumour entity with a paucity of recurrent somatic mutations and an unusually high frequency of spontaneous regression. Utilising extensive RNAi-screening we reveal the landscape and drivers of transcriptome 3'end-diversification, discovering PCF11 as critical regulator, directing alternative polyadenylation (APA) of hundreds of transcripts including a differentiation RNA-operon. Read More
J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.
Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
Chronic inflammation is a critical feature of obesity in the development of myocardial dysfunction. The observations that interleukin-6 (IL-6) is implicated in lipid and glucose homeostasis as well as its connection with the pathogenesis of insulin resistance might suggest the involvement of this cytokine in metabolic disorders of the failing heart. In the present study we aimed to assess the effects of IL-6 ablation in mice fed with normal and high fat diet on the myocardial expression of glucose and fatty acid transporting proteins, and to evaluate the paralleled alterations in lipid content. Read More