756 results match your criteria Critical Reviews in Clinical Laboratory Sciences [Journal]


MicroRNA profiling from dried blood samples.

Crit Rev Clin Lab Sci 2019 Jan 29:1-7. Epub 2019 Jan 29.

a Institute of Human Genetics, Medical Faculty , Saarland University , Homburg , Germany.

MicroRNAs (miRNAs) hold great promise as blood-borne and circulating biomarkers for numerous diseases. However, the reliability of such liquid biopsies is particularly impacted by problems associated with the handling of biological liquids in the pre-analytical stage of biomarker processing. Dried blood spots (DBS) and other capillary blood microsampling devices offer a way to circumvent many of these complications. Read More

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http://dx.doi.org/10.1080/10408363.2018.1561641DOI Listing
January 2019

D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications.

Crit Rev Clin Lab Sci 2018 Dec;55(8):548-577

a CHU UCL Namur, Namur Thrombosis and Hemostasis Center, Hematology Laboratory , Université Catholique de Louvain , Yvoir , Belgium.

D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the optimal duration of anticoagulation treatment in patients with VTE, for diagnosing disseminated intravascular coagulation, and for screening medical patients at increased risk of VTE. Read More

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http://dx.doi.org/10.1080/10408363.2018.1529734DOI Listing
December 2018
2 Reads

The immunology of the macaque placenta: A detailed analysis and critical comparison with the human placenta.

Crit Rev Clin Lab Sci 2019 Jan 11:1-28. Epub 2019 Jan 11.

b Placenta Lab, Department of Obstetrics , University Hospital Jena , Jena , Germany.

The cynomolgus monkey is increasingly considered in toxicological research as the most appropriate model for humans due to the species' close physiological contiguity, including reproductive physiology. Here, literature on the cynomolgus monkey placenta is reviewed in regards to its similarity to the human placenta and particularly for its immunological role, which is not entirely mirrored in humans. Pertinent original data are included in this article. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408363.2018.1
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http://dx.doi.org/10.1080/10408363.2018.1538200DOI Listing
January 2019
5 Reads

Delta Checks in the clinical laboratory.

Crit Rev Clin Lab Sci 2019 Jan 11:1-23. Epub 2019 Jan 11.

c Department of Core Laboratory Medicine , Gayrettepe Florence Nightingale Hospital , Istanbul , Turkey.

International standards and practice guidelines recommend the use of delta check alerts for laboratory test result interpretation and quality control. The value of contemporary applications of simple univariate delta checks determined as an absolute change, percentage change, or rate of change to recognize specimen misidentification or other laboratory errors has not received much study. This review addresses these three modes of calculation, but in line with the majority of published work, most attention is focused on the identification of specimen misidentification errors. Read More

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http://dx.doi.org/10.1080/10408363.2018.1540536DOI Listing
January 2019
6 Reads

Deep learning for image analysis: Personalizing medicine closer to the point of care.

Crit Rev Clin Lab Sci 2019 Jan 10;56(1):61-73. Epub 2019 Jan 10.

a Department of Laboratory Medicine and Pathobiology , University of Toronto , Toronto , Canada.

The precision-based revolution in medicine continues to demand stratification of patients into smaller and more personalized subgroups. While genomic technologies have largely led this movement, diagnostic results can take days to weeks to generate. Management at, or closer to, the point of care still heavily relies on the subjective qualitative interpretation of clinical and diagnostic imaging findings. Read More

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http://dx.doi.org/10.1080/10408363.2018.1536111DOI Listing
January 2019
3 Reads

Exploring the role of programmed cell death protein 1 and its ligand 1 in eye diseases.

Crit Rev Clin Lab Sci 2019 Jan 3;56(1):18-32. Epub 2019 Jan 3.

a Tianjin Medical University Eye Hospital , Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin Medical University , Tianjin , China.

Programmed death receptor-1 (PD-1) and its ligand, PD-L1, as negative co-stimulatory molecules, are indispensable for regulating both physiological and pathological immune responses. The PD-1/PD-L1-mediated signaling pathway has been studied extensively in cancer research and has become a hotspot for biopharmaceuticals and immunotherapy. Furthermore, monoclonal antibodies to PD-1 have just been approved by the US Food and Drug Administration to treat certain types of malignancies. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408363.2018.1
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http://dx.doi.org/10.1080/10408363.2018.1522292DOI Listing
January 2019
11 Reads

Novel biomarkers of cardiovascular disease: Applications in clinical practice.

Crit Rev Clin Lab Sci 2019 Jan 20;56(1):33-60. Epub 2018 Nov 20.

a Division of Medicine , Akershus University Hospital , Lørenskog , Norway.

Measurement of biomarkers has revolutionized the work-up of patients with suspected cardiovascular disease. The most widely used contemporary cardiovascular biomarkers are the natriuretic peptides in the diagnosis and prognosis of heart failure and cardiac troponins in the diagnosis of acute myocardial infarction. Numerous other biomarkers pertaining to diagnosis, prognosis, and risk prediction have been identified, but few have made their way to clinical practice. Read More

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http://dx.doi.org/10.1080/10408363.2018.1525335DOI Listing
January 2019
14 Reads

Bacterial imbalance and gut pathologies: Association and contribution of E. coli in inflammatory bowel disease.

Crit Rev Clin Lab Sci 2019 Jan 29;56(1):1-17. Epub 2018 Oct 29.

i Phase I-Early Clinical Trials Unit, Oncology Department and Multidisciplinary Oncology Center Antwerp (MOCA) , Antwerp University Hospital , Edegem , Belgium.

Hosts and microbes have co-evolved over millions of years. Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated diseases. Although the etiology of IBD remains an enigma, various studies have proposed the involvement of mucosa-associated Escherichia coli (E. Read More

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http://dx.doi.org/10.1080/10408363.2018.1517144DOI Listing
January 2019
15 Reads

Sample management for clinical biochemistry assays: Are serum and plasma interchangeable specimens?

Crit Rev Clin Lab Sci 2018 Nov 12;55(7):480-500. Epub 2018 Oct 12.

a Section of Clinical Biochemistry, Department of Neurosciences , Biomedicine and Movement Sciences, University of Verona , Verona , Italy.

The constrained economic context leads laboratories to centralize their routine analyses on high-throughput platforms, to which blood collection tubes are sent from peripheral sampling sites that are sometimes distantly located. Providing biochemistry results as quickly as possible implies to consolidate the maximum number of tests on a minimum number of blood collection tubes, mainly serum tubes and/or tubes with anticoagulants. However, depending on the parameters and their pre-analytical conditions, the type of matrix - serum or plasma - may have a significant impact on results, which is often unknown or underestimated in clinical practice. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408363.2018.1
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http://dx.doi.org/10.1080/10408363.2018.1499708DOI Listing
November 2018
3 Reads
3.692 Impact Factor

Optimizing cancer immunotherapy: Is it time for personalized predictive biomarkers?

Crit Rev Clin Lab Sci 2018 Nov 2;55(7):466-479. Epub 2018 Oct 2.

a Department of Laboratory Medicine and Pathobiology , University of Toronto , Toronto , Canada.

Cancer immunotherapy, a treatment that selectively augments a patient's anti-tumor immune response, is a breakthrough advancement in personalized medicine. A subset of cancer patients undergoing immunotherapy have displayed robust and long-lasting therapeutic responses. Currently, the spotlight is on the use of blocking antibodies against the T-cell checkpoint molecules, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programed cell death-1 (PD-1)/programed death-ligand 1 (PD-L1), which have been effectively used to combat many cancers types. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408363.2018.1
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http://dx.doi.org/10.1080/10408363.2018.1499706DOI Listing
November 2018
5 Reads

Telomere length measurement as a clinical biomarker of aging and disease.

Authors:
Clare L Fasching

Crit Rev Clin Lab Sci 2018 Nov 28;55(7):443-465. Epub 2018 Sep 28.

a Telomere Diagnostics, Inc. , Menlo Park , CA.

Telomere length measurement is increasingly recognized as a clinical gauge for age-related disease risk. There are several methods for studying blood telomere length (BTL) as a clinical biomarker. The first is an observational study approach, which directly measures telomere lengths using either cross-sectional or longitudinal patient cohorts and compares them to a population of age- and sex-matched individuals. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408363.2018.1
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http://dx.doi.org/10.1080/10408363.2018.1504274DOI Listing
November 2018
19 Reads

Exosome-carried microRNA-based signature as a cellular trigger for the evolution of chronic lymphocytic leukemia into Richter syndrome.

Crit Rev Clin Lab Sci 2018 Nov 21;55(7):501-515. Epub 2018 Sep 21.

a Research Center for Functional Genomic, Biomedicine and Translational Medicine , Iuliu Hatieganu University of Medicine and Pharmacy , Cluj Napoca , Romania.

Even if considered a cumulative and not a proliferative CD5+ B-cell neoplasm, chronic lymphocytic leukemia (CLL) has a proliferation rate higher than that recognized earlier, especially in the lymphoid tissues. Some patients with CLL develop a clinical syndrome entitled Richter syndrome (RS). Understanding CLL genetics and epigenetics may help to elucidate the molecular basics of the clinical heterogeneity of this type of malignancy. Read More

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http://dx.doi.org/10.1080/10408363.2018.1499707DOI Listing
November 2018
13 Reads

Distinguishing reference intervals and clinical decision limits - A review by the IFCC Committee on Reference Intervals and Decision Limits.

Crit Rev Clin Lab Sci 2018 09 26;55(6):420-431. Epub 2018 Jul 26.

d Hamilton General Hospital , Hamilton , Ontario , Canada.

Reference Intervals (RIs) and clinical decision limits (CDLs) are a vital part of the information supplied by laboratories to support the interpretation of numerical clinical pathology results. RIs describe the typical distribution of results seen in a healthy reference population while CDLs are associated with a significantly higher risk of adverse clinical outcomes or are diagnostic for the presence of a specific disease. However, as the two concepts are sometimes confused, there is a need to clarify the differences between these terms and to ensure they are easily distinguished, especially because CDLs have a clinical association with specific diseases and risks, thereby implying that effective clinical interventions are available. Read More

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http://dx.doi.org/10.1080/10408363.2018.1482256DOI Listing
September 2018
7 Reads

Mosaicism in autoinflammatory diseases: Cryopyrin-associated periodic syndromes (CAPS) and beyond. A systematic review.

Crit Rev Clin Lab Sci 2018 09 23;55(6):432-442. Epub 2018 Jul 23.

a Department of Medical Genetics, Rare Diseases and Personalized Medicine, CHU Montpellier , Stem Cells, Cellular Plasticity, Regenerative Medicine and Immunotherapies, INSERM, Univ Montpellier , Montpellier , France.

Autoinflammatory diseases (AIDs) are conditions related to defective regulation of the innate immune system. Sanger sequencing of the causative genes has long been the reference for confirming the diagnosis. However, for many patients with a typical AID phenotype, the genetic cause remains unknown. Read More

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http://dx.doi.org/10.1080/10408363.2018.1488805DOI Listing
September 2018
4 Reads

HbA1c method performance: The great success story of global standardization.

Crit Rev Clin Lab Sci 2018 09 12;55(6):408-419. Epub 2018 Jul 12.

b Department of Clinical Chemistry , Isala, Zwolle , the Netherlands.

Diagnosing and monitoring the treatment of people with diabetes is a global issue and uses considerable resources in laboratories and clinics worldwide. Hemoglobin A1c (HbA1c) has been the mainstay of monitoring glycemic control in people with diabetes for many years and more recently it has been advocated as a diagnostic tool for type 2 diabetes mellitus (T2DM). Good analytical performance is key to the successful use of any laboratory test, but is critical when using the test to diagnose disease, especially when the potential number of diagnoses could exceed 500 million people. Read More

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http://dx.doi.org/10.1080/10408363.2018.1480591DOI Listing
September 2018
21 Reads
3.692 Impact Factor

Blood-based analyses of cancer: Circulating myeloid-derived suppressor cells - is a new era coming?

Crit Rev Clin Lab Sci 2018 09 21;55(6):376-407. Epub 2018 Jun 21.

a 1st Chair and Department of Oncological Gynaecology and Gynaecology, Tumor Immunology Laboratory , Medical University of Lublin , Lublin , Poland.

Progress in cancer treatment made by the beginning of the 21st century has shifted the paradigm from one-size-fits-all to tailor-made treatment. The popular vision, to study solid tumors through the relatively noninvasive sampling of blood, is one of the most thrilling and rapidly advancing fields in global cancer diagnostics. From this perspective, immune-cell analysis in cancer could play a pivotal role in oncology practice. Read More

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http://dx.doi.org/10.1080/10408363.2018.1477729DOI Listing
September 2018
3 Reads

Influence of ethnicity on population reference values for biochemical markers.

Crit Rev Clin Lab Sci 2018 08 6;55(5):359-375. Epub 2018 Jun 6.

a CALIPER Program, Department of Pediatric Laboratory Medicine , The Hospital for Sick Children , Toronto , Canada.

Reference intervals (RIs) for biochemical and hematological markers determined using healthy adult and/or pediatric populations are vital for clinical interpretation of laboratory test results. Most clinical laboratories commonly use age- and sex-specific RIs, but the effect of ethnicity as a covariate is often overlooked. Ethnic differences in serum biomarker concentrations can occur as a result of genetic and environmental factors, while the degree to which each factor influences serum levels depends on the specific biomarker. Read More

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http://dx.doi.org/10.1080/10408363.2018.1476455DOI Listing
August 2018
5 Reads

Minimal residual disease in chronic lymphocytic leukemia: A consensus paper that presents the clinical impact of the presently available laboratory approaches.

Crit Rev Clin Lab Sci 2018 08 25;55(5):329-345. Epub 2018 May 25.

e Research Center for Functional Genomics and Translational Medicine , Iuliu Hatieganu University of Medicine and Pharmacy , Cluj Napoca , Romania.

Chronic lymphocytic leukemia (CLL) is a malignancy defined by the accumulation of mature lymphocytes in the lymphoid tissues, bone marrow, and blood. Therapy for CLL is guided according to the Rai and Binet staging systems. Nevertheless, state-of-the-art protocols in disease monitoring, diagnostics, and prognostics for CLL are based on the assessment of minimal residual disease (MRD). Read More

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http://dx.doi.org/10.1080/10408363.2018.1463508DOI Listing
August 2018
14 Reads

Regulatory context and validation of assays for clinical mass spectrometry proteomics (cMSP) methods.

Crit Rev Clin Lab Sci 2018 08 23;55(5):346-358. Epub 2018 May 23.

a CHU Montpellier, IRMB, Hôpital Saint Eloi, LBPC et CRB, University of Montpellier , Montpellier , France.

Clinical mass spectrometry proteomics (cMSP) assays are being increasingly used in clinical laboratories for analyzing peptides and proteins. It has therefore become urgent to characterize and validate the methods available for liquid chromatography-tandem mass spectrometry (LC/MS-MS) targeted quantification of peptide and protein biomarkers in biological fluids in the context of in vitro diagnostics. LC-MS/MS for the detection of peptides and proteins is currently the main approach used in the field of cMSP. Read More

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http://dx.doi.org/10.1080/10408363.2018.1470159DOI Listing
August 2018
4 Reads

Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives.

Crit Rev Clin Lab Sci 2018 06 20;55(4):283-293. Epub 2018 Apr 20.

b Department of Internal and Vascular Medicine , Academic Medical Center , Amsterdam , The Netherlands.

Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. Read More

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http://dx.doi.org/10.1080/10408363.2018.1463507DOI Listing
June 2018
5 Reads

Sequencing the next generation of glioblastomas.

Authors:
Ivana Jovčevska

Crit Rev Clin Lab Sci 2018 06 18;55(4):264-282. Epub 2018 Apr 18.

a Medical Center for Molecular Biology, Institute of Biochemistry, Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia.

The most aggressive brain malignancy, glioblastoma, accounts for 60-70% of all gliomas and is uniformly fatal. According to the molecular signature, glioblastoma is divided into four subtypes (proneural, neural, classical, and mesenchymal), each with its own genetic background. The Cancer Genome Atlas project provides information about the most common genetic changes in glioblastoma. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408363.2018.1
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http://dx.doi.org/10.1080/10408363.2018.1462759DOI Listing
June 2018
14 Reads

Blood biomarkers in ischemic stroke: potential role and challenges in clinical practice and research.

Crit Rev Clin Lab Sci 2018 08 18;55(5):294-328. Epub 2018 Apr 18.

c Second Department of Neurology , Attikon Hospital, National and Kapodistrian University of Athens, School of Medicine , Athens , Greece.

Fast and accurate diagnosis of stroke is crucial for the immediate application of the right therapy to patients. However, rapid diagnosis is still a challenge since an ischemic stroke cannot be identified based only on clinical assessment. CT or MRI imaging is required to rule out hemorrhagic stroke since thrombolytic therapy can lead to increased intracranial bleeding and further aggravation of hemorrhagic stroke. Read More

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http://dx.doi.org/10.1080/10408363.2018.1461190DOI Listing
August 2018
5 Reads

Novel heart failure biomarkers: why do we fail to exploit their potential?

Crit Rev Clin Lab Sci 2018 06 17;55(4):246-263. Epub 2018 Apr 17.

a Department of Cardiology , University Medical Center Groningen, University of Groningen , Groningen , The Netherlands.

Plasma biomarkers are useful tools in the diagnosis and prognosis of heart failure (HF). In the last decade, numerous studies have aimed to identify novel HF biomarkers that would provide superior and/or additional diagnostic, prognostic, or stratification utility. Although numerous biomarkers have been identified, their implementation in clinical practice has so far remained largely unsuccessful. Read More

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http://dx.doi.org/10.1080/10408363.2018.1460576DOI Listing
June 2018
7 Reads

Laboratory diagnosis of Lyme borreliosis: Current state of the art and future perspectives.

Crit Rev Clin Lab Sci 2018 06 2;55(4):219-245. Epub 2018 Apr 2.

a Institute for Laboratory Medicine, Microbiology & Infection Control , Northwest Medical Centre, Medical Faculty, Goethe University , Frankfurt/Main , Germany.

This review is directed at physicians and laboratory personnel in private practice and clinics who treat and diagnose Lyme borreliosis (LB) in patients as part of their daily work. A major objective of this paper is to bring together background information on Borrelia (B.) burgdorferi sensu lato (s. Read More

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http://dx.doi.org/10.1080/10408363.2018.1450353DOI Listing
June 2018
5 Reads

Thyroglobulin measurement in the management of patients with differentiated thyroid cancer.

Crit Rev Clin Lab Sci 2018 05 16;55(3):205-218. Epub 2018 Mar 16.

a Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester , MN , USA.

The post-operative management of patients with differentiated thyroid carcinoma (DTC) relies on serial measurements of serum thyroglobulin. Current methodologies for thyroglobulin quantitation vary in their analytical and clinical performance. For years, thyroglobulin radioimmunoassays (RIA) and immunometric assays (IMA) have been used despite analytical interferences from anti-thyroglobulin autoantibodies (TgAb) as well as heterophile antibodies (HAb). Read More

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http://dx.doi.org/10.1080/10408363.2018.1450830DOI Listing
May 2018
7 Reads

Laboratory evaluation of the IFN-γ circuit for the molecular diagnosis of Mendelian susceptibility to mycobacterial disease.

Crit Rev Clin Lab Sci 2018 05 4;55(3):184-204. Epub 2018 Mar 4.

d Laboratory of Human Genetics of Infectious Diseases, Necker Branch , INSERM-U1163 , Paris , France.

The integrity of the interferon (IFN)-γ circuit is necessary to mount an effective immune response to intra-macrophagic pathogens, especially Mycobacteria. Inherited monogenic defects in this circuit that disrupt the production of, or response to, IFN-γ underlie a primary immunodeficiency known as Mendelian susceptibility to mycobacterial disease (MSMD). Otherwise healthy patients display a selective susceptibility to clinical disease caused by poorly virulent mycobacteria such as BCG (bacille Calmette-Guérin) vaccines and environmental mycobacteria, and more rarely by other intra-macrophagic pathogens, particularly Salmonella and M. Read More

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http://dx.doi.org/10.1080/10408363.2018.1444580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880527PMC
May 2018
20 Reads

Diagnostic criteria and contributors to Gilbert's syndrome.

Crit Rev Clin Lab Sci 2018 03 1;55(2):129-139. Epub 2018 Feb 1.

b School of Medical Science and Menzies Health Institute Queensland , Griffith University , Gold Coast , Australia.

Hyperbilirubinemia is a well-known condition in the clinical setting; however, the causes of elevated serum bilirubin are diverse, as are the clinical ramifications of this condition. For example, diagnoses of individuals vary depending on whether they exhibit an unconjugated or conjugated hyperbilirubinemia. Diagnoses can include conditions of disordered bilirubin metabolism (Gilbert's, Crigler-Najjar, Rotor, or Dubin-Johnson syndromes) or an acquired disease, including alcoholic/non-alcoholic fatty liver disease, hepatotropic hepatitis, cirrhosis, or hepato-biliary malignancy. Read More

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http://dx.doi.org/10.1080/10408363.2018.1428526DOI Listing
March 2018
10 Reads

Endogenous markers for kidney function in children: a review.

Crit Rev Clin Lab Sci 2018 05 1;55(3):163-183. Epub 2018 Feb 1.

a Department of Pediatric Nephrology , VU Medical Centre , Amsterdam , The Netherlands.

Although glomerular filtration rate (GFR) in children can be measured using a gold-standard technique following injection of an exogenous marker, this invasive and cumbersome technique is not widely available and GFR is commonly estimated using serum levels of endogenous markers. Creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin are well-established endogenous markers of kidney function. These markers differ in site of production and effects of diet and medication, as well as renal-tubular handling and extra-renal elimination. Read More

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http://dx.doi.org/10.1080/10408363.2018.1427041DOI Listing
May 2018
7 Reads

Advances in liquid biopsy on-chip for cancer management: Technologies, biomarkers, and clinical analysis.

Crit Rev Clin Lab Sci 2018 05 1;55(3):140-162. Epub 2018 Feb 1.

a Thayer School of Engineering , Dartmouth College , Hanover , NH , USA.

Liquid biopsy, as a minimally invasive method of gleaning insight into the dynamics of diseases through a patient fluid sample, has been growing in popularity for cancer diagnosis, prognosis, and monitoring. While many technologies have been developed and validated in research laboratories, there has also been a push to expand these technologies into other clinical settings and as point of care devices. In this article, we discuss and evaluate microchip-based technologies for circulating tumor cell (CTC), exosome, and circulating tumor nucleic acid (ctNA) capture, detection, and analysis. Read More

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http://dx.doi.org/10.1080/10408363.2018.1425976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101655PMC
May 2018
43 Reads

Niche point-of-care endocrine testing - Reviews of intraoperative parathyroid hormone and cortisol monitoring.

Crit Rev Clin Lab Sci 2018 03 22;55(2):115-128. Epub 2018 Jan 22.

b Laboratory Medicine and Pathology , Mayo Clinic , Rochester , MN , USA.

Point-of-care (POC) testing, which provides quick test results in near-patient settings with easy-to-use devices, has grown continually in recent decades. Among near-patient and on-site tests, rapid intraoperative and intra-procedural assays are used to quickly deliver critical information and thereby improve patient outcomes. Rapid intraoperative parathyroid hormone (ioPTH) monitoring measures postoperative reduction of parathyroid hormone (PTH) to predict surgical outcome in patients with primary hyperparathyroidism, and therefore contributes to the change of parathyroidectomy to a minimally invasive procedure. Read More

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http://dx.doi.org/10.1080/10408363.2018.1425975DOI Listing
March 2018
8 Reads

Hodgkin's lymphoma and its association with EBV and HIV infection.

Crit Rev Clin Lab Sci 2018 03 9;55(2):102-114. Epub 2018 Jan 9.

a Department of Pathology, Division of Haematopathology , National Health Laboratory Service, Stellenbosch University , Cape Town , South Africa.

Hodgkin's lymphoma (HL) constitutes a clonal expansion of what appears to be malignant B cells. Viruses are involved in its pathogenesis, such as the Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV). Since these viral infections have been shown to play key roles in the pathogenesis of HL, countries with a prevalence of HIV and EBV represent interesting population targets to study the pathogenesis of HL, linking the evolution of the disease with viral infections. Read More

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http://dx.doi.org/10.1080/10408363.2017.1422692DOI Listing
March 2018
8 Reads
3.690 Impact Factor

Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring.

Crit Rev Clin Lab Sci 2018 03 8;55(2):71-101. Epub 2018 Jan 8.

a Department of Pharmacology & Therapeutics , University of Manitoba , Winnipeg , Canada.

Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility and adult lifestyle are implicated in these trends, evidence from clinical cohorts, epidemiological studies and animal model experiments support a role for early-life environmental exposures in determining the long-term health of an individual, which has led to the formulation of the Developmental Origins of Health and Disease (DOHaD) theory. In fact, maternal obesity and diabetes during pregnancy, which are on the rise, are strongly associated with altered fetal growth and development as well as with lifelong perturbations in metabolic tissues. Read More

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http://dx.doi.org/10.1080/10408363.2017.1422109DOI Listing
March 2018
10 Reads

Cell-free DNA as a biomarker in stroke: Current status, problems and perspectives.

Crit Rev Clin Lab Sci 2018 01 5;55(1):55-70. Epub 2018 Jan 5.

a Laboratory of Molecular Biology , Federal State Budgetary Institution "Research Centre for Medical Genetics" , Moscow , Russia.

There is currently no proposed stroke biomarker with consistent application in clinical practice. A number of studies have examined cell-free DNA (cfDNA), which circulates in biological fluids during stroke, as a potential biomarker of this disease. The data available suggest that dynamically-determined levels of blood cfDNA may provide new prognostic information for assessment of stroke severity and outcome. Read More

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http://dx.doi.org/10.1080/10408363.2017.1420032DOI Listing
January 2018
5 Reads

Lipoprotein(a) in clinical practice: New perspectives from basic and translational science.

Crit Rev Clin Lab Sci 2018 01 20;55(1):33-54. Epub 2017 Dec 20.

d Department of Biochemistry , Western University , London , Canada.

Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are a causal risk factor for coronary heart disease (CHD) and calcific aortic valve stenosis (CAVS). Genetic, epidemiological and in vitro data provide strong evidence for a pathogenic role for Lp(a) in the progression of atherothrombotic disease. Despite these advancements and a race to develop new Lp(a) lowering therapies, there are still many unanswered and emerging questions about the metabolism and pathophysiology of Lp(a). Read More

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http://dx.doi.org/10.1080/10408363.2017.1415866DOI Listing
January 2018
12 Reads

Serum and plasma amino acids as markers of prediabetes, insulin resistance, and incident diabetes.

Crit Rev Clin Lab Sci 2018 01 14;55(1):21-32. Epub 2017 Dec 14.

a Diabetes Research Group , Medizinische Klinik und Poliklinik IV, Klinikum der Universität München , Munich , Germany.

Presently, routine screening misses many cases of prediabetes and early type 2 diabetes (T2D). Therefore, better biomarkers are needed for a simple and early detection of abnormalities of glucose metabolism and prediction of future T2D. Possible candidates for this include plasma or serum amino acids because glucose and amino acid metabolism are closely connected. Read More

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http://dx.doi.org/10.1080/10408363.2017.1414143DOI Listing
January 2018
8 Reads

Applications of mid-infrared spectroscopy in the clinical laboratory setting.

Crit Rev Clin Lab Sci 2018 01 14;55(1):1-20. Epub 2017 Dec 14.

a Department of Clinical Chemistry , Ghent University Hospital , Ghent , Belgium.

Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool. Therefore, it has many potential applications in different fields of clinical laboratory science. Read More

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http://dx.doi.org/10.1080/10408363.2017.1414142DOI Listing
January 2018
13 Reads

Cardiac troponins: 25 years on the stage and still improving their clinical value.

Crit Rev Clin Lab Sci 2017 Nov - Dec;54(7-8):551-571. Epub 2017 Dec 11.

d Clinical Biochemistry Department , Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau , Barcelona , Spain.

Twenty-five years ago, non-isotopic immunoassays for measuring the cardiac specific isoforms of troponin I (cTnI) and T (cTnT) were developed. Both biomarkers radically changed the diagnosis, prognosis, and therapy indication of acute coronary syndromes (ACS) and, particularly, of myocardial infarction (MI). However, cardiac troponins (cTn) rapidly demonstrated their usefulness in other cardiac and non-cardiac conditions, a part of the ischemic coronary diseases. Read More

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http://dx.doi.org/10.1080/10408363.2017.1410777DOI Listing
April 2018
16 Reads

Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory.

Crit Rev Clin Lab Sci 2017 Nov - Dec;54(7-8):529-550. Epub 2017 Dec 11.

a Center for Biomedical Network Research on Rare Diseases (CIBERER) , Institute of Health Carlos III , Valencia , Spain.

Epigenetic modifications and regulators represent potential molecular elements which control relevant physiological and pathological features, thereby contributing to the natural history of human disease. These epigenetic modulators can be employed as disease biomarkers, since they show several advantages and provide information about gene function, thus explaining differences among patient endophenotypes. In addition, epigenetic biomarkers can incorporate information regarding the effects of the environment and lifestyle on health and disease, and monitor the effect of applied therapies. Read More

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http://dx.doi.org/10.1080/10408363.2017.1410520DOI Listing
April 2018
52 Reads

Clinical and molecular aspects of lead toxicity: An update.

Crit Rev Clin Lab Sci 2017 Nov - Dec;54(7-8):506-528. Epub 2017 Dec 7.

a Department of Biochemistry , All India Institute of Medical Sciences , Jodhpur , India.

Lead toxicity is a major public health issue in developed and developing countries. Both acute and chronic lead exposure has the potential to cause many deleterious systematic effects including hypertension, frank anemia, cognitive deficits, infertility, immune imbalances, delayed skeletal and deciduous dental development, vitamin D deficiency, and gastrointestinal effects. The underlying mechanisms for all these systemic effects have not been elucidated completely. Read More

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http://dx.doi.org/10.1080/10408363.2017.1408562DOI Listing
April 2018
15 Reads

Synovial fluid proteomics in the pursuit of arthritis mediators: An evolving field of novel biomarker discovery.

Crit Rev Clin Lab Sci 2017 Nov - Dec;54(7-8):495-505. Epub 2017 Dec 4.

a Department of Laboratory Medicine and Pathobiology , University of Toronto , Toronto , Canada.

Synovial fluid (SF) is a protein-rich fluid produced into the joint cavity by cells of the synovial membrane. Due to its direct contact with articular cartilage, surfaces of the bone, and the synoviocytes of the inner membrane, it provides a promising reflection of the biochemical state of the joint under varying physiological and pathophysiological conditions. This property of SF has been exploited within numerous studies in search of unique biomarkers of joint pathologies with the ultimate goal of developing minimally invasive clinical assays to detect and/or monitor disease states. Read More

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April 2018
12 Reads

Point-of-care testing (POCT) and evidence-based laboratory medicine (EBLM) - does it leverage any advantage in clinical decision making?

Crit Rev Clin Lab Sci 2017 Nov - Dec;54(7-8):471-494. Epub 2017 Nov 23.

f University of Stellenbosch and National Health Laboratory Service (NHLS), Tygerberg Hospital , Cape Town , South Africa.

Point-of-care testing (POCT) is the analysis of patient specimens outside the clinical laboratory, near or at the site of patient care, usually performed by clinical staff without laboratory training, although it also encompasses patient self-monitoring. It is able to provide a rapid result near the patient and which can be acted upon immediately. The key driver is the concept that clinical decision making may be delayed when samples are sent to the clinical laboratory. Read More

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http://dx.doi.org/10.1080/10408363.2017.1399336DOI Listing
April 2018
74 Reads
3.692 Impact Factor

The vascular endothelium: A regulator of arterial tone and interface for the immune system.

Crit Rev Clin Lab Sci 2017 Nov - Dec;54(7-8):458-470. Epub 2017 Oct 30.

a Department of Physiology and Pharmacology, Cumming School of Medicine , University of Calgary, and Libin Cardiovascular Institute of Alberta , Calgary , Canada.

As the primary interface between the blood and various tissues of the body, the vascular endothelium exhibits a diverse range of roles and activities, all of which contribute to the overall health and function of the cardiovascular system. In this focused review, we discuss several key aspects of endothelial function, how this may be compromised and subsequent consequences. Specifically, we examine the dynamic regulation of arterial contractility and distribution of blood flow through the generation of chemical and electrical signaling events that impinge upon vascular smooth muscle. Read More

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http://dx.doi.org/10.1080/10408363.2017.1394267DOI Listing
April 2018
46 Reads
4 Citations
3.692 Impact Factor

High-resolution proteomics and metabolomics in thyroid cancer: Deciphering novel biomarkers.

Crit Rev Clin Lab Sci 2017 Nov - Dec;54(7-8):446-457. Epub 2017 Oct 30.

d Proteomic Unit , Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Universidad de Murcia , Murcia , Spain.

The incidence of thyroid cancer (TC) - the most common endocrine malignancy - has been increasing sharply since the mid-1990s. The rate of TC incidence in both men and women has been faster than any other cancer. Both improved diagnoses (i. Read More

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http://dx.doi.org/10.1080/10408363.2017.1394266DOI Listing
April 2018
18 Reads

Onco-proteogenomics: Multi-omics level data integration for accurate phenotype prediction.

Crit Rev Clin Lab Sci 2017 09 12;54(6):414-432. Epub 2017 Oct 12.

a Department of Laboratory Medicine and Pathobiology , University of Toronto , Toronto , ON , Canada.

The overall goal of translational oncology is to identify molecular alterations indicative of cancer or of responsiveness to specific therapeutic regimens. While next-generation sequencing has played a pioneering role in this quest, the latest advances in proteomic technologies promise to provide a holistic approach to the further elucidation of tumor biology. Genetic information may be written in DNA and flow from DNA to RNA to protein, according to the central dogma of molecular biology, but the observed phenotype is dictated predominantly by the DNA protein coding region-derived proteotype. Read More

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http://dx.doi.org/10.1080/10408363.2017.1384446DOI Listing
September 2017
9 Reads

The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper.

Crit Rev Clin Lab Sci 2017 09 11;54(6):358-413. Epub 2017 Oct 11.

b Department of Laboratory Medicine & Pathobiology, Faculty of Medicine , University of Toronto , Toronto , Canada.

Laboratory investigations provide physicians with objective data to aid in disease diagnosis, clinical decision making, and patient follow up. Clinical interpretation of laboratory test results relies heavily on the availability of appropriate population-based reference intervals (i.e. Read More

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http://dx.doi.org/10.1080/10408363.2017.1379945DOI Listing
September 2017
17 Reads

Urine and oral fluid drug testing in support of pain management.

Crit Rev Clin Lab Sci 2017 09 9;54(6):433-445. Epub 2017 Oct 9.

c Immunalysis Corporation , Pomona , CA , USA.

In recent years, the abuse of opioid drugs has resulted in greater prevalence of addiction, overdose, and deaths attributable to opioid abuse. The epidemic of opioid abuse has prompted professional and government agencies to issue practice guidelines for prescribing opioids to manage chronic pain. An important tool available to providers is the drug test for use in the initial assessment of patients for possible opioid therapy, subsequent monitoring of compliance, and documentation of suspected aberrant drug behaviors. Read More

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http://dx.doi.org/10.1080/10408363.2017.1385053DOI Listing
September 2017
13 Reads

Targeting the endothelial glycocalyx in acute critical illness as a challenge for clinical and laboratory medicine.

Crit Rev Clin Lab Sci 2017 08 29;54(5):343-357. Epub 2017 Sep 29.

b Centrum for Research and Development, University Hospital , Hradec Kralove , Czech Republic.

The purpose of this manuscript is to review the role of endothelial glycocalyx (EG) in the field of critical and perioperative medicine and to discuss possible future directions for investigations in this area. Under physiological conditions, EG has several well-defined functions aimed to prevent the disruption of vessel wall integrity. Under pathological conditions, the EG represent one of the earliest sites of injury during inflammation. Read More

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http://dx.doi.org/10.1080/10408363.2017.1379943DOI Listing
August 2017
25 Reads

Biomarkers of diabetic nephropathy: A 2017 update.

Crit Rev Clin Lab Sci 2017 08 28;54(5):326-342. Epub 2017 Sep 28.

d Department of Clinical Biochemistry , "Aghia Sophia" Children's Hospital , Athens , Greece.

Diabetic nephropathy (DN), also named diabetic kidney disease (DKD), is a devastating complication in patients with both type 1 and 2 diabetes mellitus (T1D and T2D) and its diagnosis has been traditionally based on the presence of micro-albuminuria (MA). The aim of this article is to update, through review of the relevant medical literature, the most promising biomarkers for early DKD detection. MA has historically been employed as an early marker of microvascular complications, indicating risk for advanced CKD. Read More

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http://dx.doi.org/10.1080/10408363.2017.1377682DOI Listing
August 2017
42 Reads

Typing the atypical: Diagnostic issues and predictive markers in suspicious prostate lesions.

Crit Rev Clin Lab Sci 2017 08 22;54(5):309-325. Epub 2017 Aug 22.

c Department of Urology and Renal Transplantation , University of Foggia , Foggia , Italy.

As much as 5% of prostate biopsies yield findings equivocal for malignancy even for skilled uropathologist; such "grey zone" lesions have been addressed in many ways, although the acronym ASAP (atypical small acinar proliferation) is the most widely used when referring to an atypical focus suspicious, but not diagnostic, for malignancy. Since the introduction of this diagnostic category more than 20 years ago, debate has ensued over its histological characterization and clinical significance. Pathology reporting of ASAP, commonly based on strict morphological criteria and traditional immunohistochemical markers such as basal cell antibodies, has been improved by recent availability of novel immunohistochemical markers such as AMACR and ERG. Read More

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http://dx.doi.org/10.1080/10408363.2017.1363155DOI Listing
August 2017
37 Reads

Capillary blood for point-of-care testing.

Crit Rev Clin Lab Sci 2017 08 1;54(5):294-308. Epub 2017 Aug 1.

c Bioinspired Engineering and Biomechanics Center (BEBC) , Xi'an Jiaotong University , Xi'an , P.R. China.

Clinically, blood sample analysis has been widely used for health monitoring. In hospitals, arterial and venous blood are utilized to detect various disease biomarkers. However, collection methods are invasive, painful, may result in injury and contamination, and skilled workers are required, making these methods unsuitable for use in a resource-limited setting. Read More

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http://dx.doi.org/10.1080/10408363.2017.1343796DOI Listing
August 2017
16 Reads