685 results match your criteria Critical Reviews in Biotechnology [Journal]


Optimization of a raceway pond system for wastewater treatment: a review.

Crit Rev Biotechnol 2019 Feb 11:1-14. Epub 2019 Feb 11.

a LGPM, CentraleSupélec, SFR Condorcet FR CNRS 3417, Université de Paris-Saclay, Centre Européen de Biotechnologie et de Bioéconomie (CEBB) , Pomacle , France.

Microalgae are photosynthetic microorganisms with potential for biofuel production, CO mitigation and wastewater treatment; indeed they have the capacity to assimilate pollutants in wastewaters. Light supply and distribution among the microalgae culture is one of the major challenges of photo-bioreactor design, with many studies focusing on microalgae culture systems such as raceway ponds (RWP), widely used and cost-effective systems for algal biomass production. This review focuses on possible improvements of the RWP design in order to achieve optimal microalgal growth conditions and high biomass productivities, to minimize energy consumption and to lower the capital costs of the pond. Read More

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http://dx.doi.org/10.1080/07388551.2019.1571007DOI Listing
February 2019

Biosynthesis of polymalic acid in fermentation: advances and prospects for industrial application.

Crit Rev Biotechnol 2019 Feb 10:1-14. Epub 2019 Feb 10.

b William G. Lowrie Department of Chemical and Biomolecular Engineering , The Ohio State University , Columbus , OH , USA.

Some microorganisms naturally produce β-poly(l-malic acid) (PMA), which has excellent water solubility, biodegradability, and biocompatibility properties. PMA has broad prospective applications as novel biopolymeric materials and carriers in the drug, food, and biomedical fields. Malic acid, a four-carbon dicarboxylic acid, is widely used in foods and pharmaceuticals, as a platform chemical. Read More

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http://dx.doi.org/10.1080/07388551.2019.1571008DOI Listing
February 2019

Co-evolution of physical and social sciences in synthetic biology.

Crit Rev Biotechnol 2019 Feb 6:1-15. Epub 2019 Feb 6.

b US Army Engineer Research and Development Center , Vicksburg , MS , USA.

Emerging technologies research often covers various perspectives in disciplines and research areas ranging from hard sciences, engineering, policymaking, and sociology. However, the interrelationship between these different disciplinary domains, particularly the physical and social sciences, often occurs many years after a technology has matured and moved towards commercialization. Synthetic biology may serve an exception to this idea, where, since 2000, the physical and the social sciences communities have increasingly framed their research in response to various perspectives in biological engineering, risk assessment needs, governance challenges, and the social implications that the technology may incur. Read More

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http://dx.doi.org/10.1080/07388551.2019.1566203DOI Listing
February 2019

Toward biotherapeutic product real-time quality monitoring.

Crit Rev Biotechnol 2019 Feb 6:1-17. Epub 2019 Feb 6.

a School of Chemical Engineering and Advanced Materials , Newcastle University , Newcastle upon Tyne , United Kingdom.

Biotherapeutics, such as those derived from monoclonal antibodies (mAbs), are industrially produced in controlled multiunit operation bioprocesses. Each unit operation contributes to the final characteristics of the bioproduct. The complexity of the bioprocesses, the cellular machinery, and the bioproduct molecules, typically leads to inherent heterogeneity and variability of the final critical quality attributes (CQAs). Read More

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http://dx.doi.org/10.1080/07388551.2018.1524362DOI Listing
February 2019

Potential application of Leishmania tarentolae as an alternative platform for antibody expression.

Crit Rev Biotechnol 2019 Feb 5:1-15. Epub 2019 Feb 5.

a Institute for Research in Molecular Medicine, Universiti Sains Malaysia , Penang , Malaysia.

Through the discovery of monoclonal antibody (mAb) technology, profound successes in medical treatment against a wide range of diseases have been achieved. This has led antibodies to emerge as a new class of biodrugs. As the "rising star" in the pharmaceutical market, extensive research and development in antibody production has been carried out in various expression systems including bacteria, insects, plants, yeasts, and mammalian cell lines. Read More

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http://dx.doi.org/10.1080/07388551.2019.1566206DOI Listing
February 2019

DEAD box helicases as promising molecular tools for engineering abiotic stress tolerance in plants.

Crit Rev Biotechnol 2019 Feb 3:1-13. Epub 2019 Feb 3.

a Centre for Plant Molecular Biology, Osmania University , Hyderabad , India.

Diverse abiotic stresses constitute one of the major factors which adversely affect the normal plant growth and development which results worldwide in decreased agricultural productivity. At present, utilization of new molecular tools to achieve improved stress tolerance and increased crop productivity is highly desirable. Abiotic stress in plants induces expression of a wide range of genes like transcription factors, defense related genes and so on, and the products of these genes are important in combating stress conditions. Read More

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http://dx.doi.org/10.1080/07388551.2019.1566204DOI Listing
February 2019

Structural insights into alcohol dehydrogenases catalyzing asymmetric reductions.

Crit Rev Biotechnol 2019 Jan 30:1-14. Epub 2019 Jan 30.

a School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education , Jiangnan University , Wuxi , China.

Alcohol dehydrogenases are a group of oxidoreductases that specifically use NAD(P) or NAD(P)H as cofactors for electron acceptance or donation and catalyze interconversion between alcohols and corresponding carbonyl compounds. In addition to their physiological roles in metabolizing alcohols and aldehydes or ketones, alcohol dehydrogenases have received considerable attention with respect to their symmetry-breaking traits in catalyzing asymmetric reactions and have Accordingly, they have become widely applied in fine chemical synthesis, particularly in the production of chiral alcohols and hydroxyl compounds that are key elements in the synthesis of active pharmaceutical ingredients (API) employed in the pharmaceutical industry. The application of structural bioinformatics to the study of functional enzymes and recent scientific breakthroughs in modern molecular biotechnology provide us with an effective alternative to gain an understanding of the molecular mechanisms involved in asymmetric bioreactions and in overcoming the limitations of enzyme availability. Read More

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http://dx.doi.org/10.1080/07388551.2019.1566205DOI Listing
January 2019
7.178 Impact Factor

Advances and challenges in the production of extracellular thermoduric pullulanases by wild-type and recombinant microorganisms: a review.

Crit Rev Biotechnol 2019 Jan 30:1-14. Epub 2019 Jan 30.

a Department of Chemical Engineering and Biotechnological Engineering , Faculty of Engineering, University of Sherbrooke , Sherbrooke , Canada.

Thermoduric pullulanases, acting as starch-debranching enzymes, are required in many industrial applications, mainly in the production of concentrated glucose, maltose, and fructose syrups. To date, however, a single pullulanase, from Bacillus acidopullulyticus, is available on the market for industrial purposes. This review is an investigation of the major advances as well as the major challenges being faced with regard to optimization of the production of extracellular thermoduric pullulanases either by their original hosts or by recombinant organisms. Read More

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http://dx.doi.org/10.1080/07388551.2019.1566202DOI Listing
January 2019

Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids.

Crit Rev Biotechnol 2019 Jan 17:1-15. Epub 2019 Jan 17.

a National Agricultural Technology Institute , Institute of Virology and Technological Innovations IVIT, CONICET-INTA, Hurlingham , Buenos Aires , Argentina.

Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which causes severe economic losses in the livestock industry. Currently available vaccines are based on inactivated FMD virus (FMDV). Although inactivated virus vaccines have proved to be effective in FMD control, they have a number of disadvantages, including the need for high bio-containment production facilities and the lack of induction of immunological memory. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1554619DOI Listing
January 2019
8 Reads

The CRISPR/Cas9 system and its applications in crop genome editing.

Crit Rev Biotechnol 2019 Jan 15:1-16. Epub 2019 Jan 15.

c Institute of Research and Development, Duy Tan University , Da Nang, Vietnam.

The CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR associated protein9) system is an RNA-guided genome editing tool that consists of a Cas9 nuclease and a single-guide RNA (sgRNA). By base-pairing with a DNA target sequence, the sgRNA enables Cas9 to recognize and cut a specific target DNA sequence, generating double strand breaks (DSBs) that trigger cell repair mechanisms and mutations at or near the DSBs sites. Since its discovery, the CRISPR/Cas9 system has revolutionized genome editing and is now becoming widely utilized to edit the genomes of a diverse range of crop plants. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1554621DOI Listing
January 2019
19 Reads

Bacteria and nanosilver: the quest for optimal production.

Crit Rev Biotechnol 2019 Mar 2;39(2):272-287. Epub 2019 Jan 2.

a School of Engineering & Institute for Life Sciences , University of Southampton , Southampton , UK.

Silver nanoparticles (AgNPs) have potential uses in many applications, but current chemical production methods are challenged by scalability, limited particle stability, and the use of hazardous chemicals. The biological processes present in bacteria to mitigate metallic contaminants in their environment present a potential solution to these challenges. Before commercial exploitation of this technology can be achieved, the quality of bacteriogenic AgNPs needs to be improved for certain applications. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1555130DOI Listing
March 2019
3 Reads

Fed-batch high-cell-density fermentation strategies for Pichia pastoris growth and production.

Crit Rev Biotechnol 2019 Mar 2;39(2):258-271. Epub 2019 Jan 2.

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines; NHC Key Laboratory of Biosynthesis of Natural Products , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , P. R. China.

Pichia pastoris is extensively used to produce various heterologous proteins. Amounts of biopharmaceutical drugs and industrial enzymes have been successfully produced by fed-batch high-cell-density fermentation (HCDF) of this cell factory. High levels of cell mass in defined media can be easily achieved and therefore large quantities of recombinant proteins with enhanced activities and lower costs can be obtained through HCDF technology. Read More

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http://dx.doi.org/10.1080/07388551.2018.1554620DOI Listing
March 2019
1 Read
7.178 Impact Factor

Current status and perspectives of 2-phenylethanol production through biological processes.

Crit Rev Biotechnol 2019 Mar 20;39(2):235-248. Epub 2018 Dec 20.

a State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering , Nanjing Tech University , Nanjing , China.

2-Phenylethanol (2-PE), an important flavor and fragrance compound with a rose-like smell has been widely used in the cosmetics, perfume, and food industries. Traditional production of 2-PE was mainly through the extraction from plant materials or by chemical synthesis. However, the increasing demand of consumers for natural flavors cannot be met by these methods. Read More

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http://dx.doi.org/10.1080/07388551.2018.1530634DOI Listing
March 2019
12 Reads

Current studies on the enzymatic preparation 2-O-α-d-glucopyranosyl-l-ascorbic acid with cyclodextrin glycosyltransferase.

Crit Rev Biotechnol 2019 Mar 18;39(2):249-257. Epub 2018 Dec 18.

a State Key Laboratory of Food Science and Technology , Jiangnan University , Wuxi , China.

2-O-α-d-glucopyranosyl-l-ascorbic acid (AA-2G) is one of the most important l-ascorbic acid derivatives because of its resistance to reduction and oxidation and its easy degradation by α-glucosidase to release l-ascorbic acid and glucose. Thus, AA-2G has commercial uses in food, medicines and cosmetics. This article presents a review of recent studies on the enzymatic production of AA-2G using cyclodextrin glycosyltransferase. Read More

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http://dx.doi.org/10.1080/07388551.2018.1531823DOI Listing
March 2019
1 Read
7.178 Impact Factor

Bioreactor-based advances in plant tissue and cell culture: challenges and prospects.

Crit Rev Biotechnol 2018 Nov 15:1-15. Epub 2018 Nov 15.

g Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences , Universiti Putra Malaysia , Serdang , Selangor DE 43400 UPM , Malaysia.

Bioreactors are engineered systems capable of supporting a biologically active situation for conducting aerobic or anaerobic biochemical processes. Stability, operational ease, improved nutrient uptake capacity, time- and cost-effectiveness, and large quantities of biomass production, make bioreactors suitable alternatives to conventional plant tissue and cell culture (PTCC) methods. Bioreactors are employed in a wide range of plant research, and have evolved over time. Read More

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http://dx.doi.org/10.1080/07388551.2018.1489778DOI Listing
November 2018
2 Reads

Biotechnology in ciliates: an overview.

Crit Rev Biotechnol 2019 Mar 13;39(2):220-234. Epub 2018 Nov 13.

a Facultad de Farmacia y Bioquímica, Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Nanobiotecnología (NANOBIOTEC) , Universidad de Buenos Aires , Buenos Aires , Argentina.

Since their description and classification in the 19th century, ciliates have played an important role in science, leading to several fundamental discoveries in the areas of cellular and molecular biology. During the last decades, with the emergence of biotechnology, many new developments are also coming to light. In this review, we describe a range of applications in which ciliates have found a niche, ranging from the production of a vast array of proteins, lipids, metabolites, and antigens to their use in toxicity screening, biocontrol, bioremediation, and biotransformation of substrates into more valuable products. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1530188DOI Listing
March 2019
10 Reads

The nanotechnology among US: are metal and metal oxides nanoparticles a nano or mega risk for soil microbial communities?

Crit Rev Biotechnol 2019 Mar 5;39(2):157-172. Epub 2018 Nov 5.

b Chemical Engineering Department , Universidad de La Frontera , Temuco , Chile.

Metal nanoparticles and metal oxides nanoparticles (MNPs/MONPs) have been widely included in a great diversity of products and industrial applications and they are already a part of our everyday life. According to estimation studies, their production is expected to increase exponentially in the next few years. Consequently, soil has been suggested as the main sink of MNPs/MONPs once they are deliberately or accidentally released into the environment. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1523865DOI Listing
March 2019
5 Reads

A breakthrough in the artificial cultivation of Chinese cordyceps on a large-scale and its impact on science, the economy, and industry.

Crit Rev Biotechnol 2019 Mar 4;39(2):181-191. Epub 2018 Nov 4.

a State Key Laboratory of Mycology, Institute of Microbiology , Chinese Academy of Sciences , Beijing , China.

Chinese cordyceps, an entity of the Chinese caterpillar fungus (Ophiocordyceps sinensis, syn. Cordyceps sinensis) that parasitizes ghost moth larvae, is one of the best known traditional Chinese medicines and is found exclusively on the Tibetan Plateau with limited natural resources. Although the fungus O. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1531820DOI Listing
March 2019
30 Reads

Multi-point enzyme immobilization, surface chemistry, and novel platforms: a paradigm shift in biocatalyst design.

Crit Rev Biotechnol 2019 Mar 4;39(2):202-219. Epub 2018 Nov 4.

e Tecnologico de Monterrey, School of Engineering and Sciences , Campus Monterrey , Monterrey , Mexico.

Engineering enzymes with improved catalytic properties in non-natural environments have been concerned with their diverse industrial and biotechnological applications. Immobilization represents a promising but straightforward route, and immobilized biocatalysts often display higher activities and stabilities compared to free enzymes. Owing to their unique physicochemical characteristics, including the high-specific surface area, exceptional chemical, electrical, and mechanical properties, efficient enzyme loading, and multivalent functionalization, nano-based materials are postulated as suitable carriers for biomolecules or enzyme immobilization. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1531822DOI Listing
March 2019
14 Reads

A current approach to the control of filamentous fungal growth in media: microparticle enhanced cultivation technique.

Crit Rev Biotechnol 2019 Mar 4;39(2):192-201. Epub 2018 Nov 4.

a Department of Food Engineering , Akdeniz University , Antalya , Turkey.

Various strategies have been carried out to date in order to overcome the problem of the adverse effects of bulk fungal growth in bioreactors. Nevertheless, previous conventional methods such as modifying the cultivation temperature or pH resulted in limited biomass production and consequently lower yields. In recent years microparticle enhanced cultivation (MPEC) techniques are one of the most remarkable and novel methods employed for submerged fungal production to overcome bulk microbial growth. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1531821DOI Listing
March 2019
7 Reads

Transcriptome and miRNAs analyses enhance our understanding of the evolutionary advantages of polyploidy.

Crit Rev Biotechnol 2019 Mar 29;39(2):173-180. Epub 2018 Oct 29.

a Biology Department , Saint Mary's University , Halifax , Canada.

Polyploid organisms have more than two sets of chromosomes, including autopolyploid via intraspecific genome doubling, and allopolyploid via merging genomes of distinct species by hybridization. Polyploid organisms are widespread in plants, indicating that polyploidy has some evolutionary advantages over its diploid ancestor. Actually, polyploidy is always tightly associated with hybrid vigor and adaptation to adverse environmental conditions. Read More

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http://dx.doi.org/10.1080/07388551.2018.1524824DOI Listing
March 2019
11 Reads

Current state and prospects of biotechnology in Central and Eastern European countries. Part II: new and preaccession EU countries(CRO, RO, B&H, SRB).

Crit Rev Biotechnol 2018 Oct 29:1-19. Epub 2018 Oct 29.

b Department of Biotechnology, Faculty of Natural Sciences , University of SS. Cyril and Methodius in Trnava , Slovakia.

Innovation holds the potential for economic prosperity. Biotechnology (BT) has proved to be a viable vehicle for the development and utilization of technologies, which has brought not only advances to society, but also career opportunities to nation-states that have enabling conditions. In this review, we assess the current state of BT-related activities within selected new and preaccession EU countries (NPA) of CEE region namely Croatia, Romania, Bosnia and Herzegovina and Serbia, examining educational programs, research activity, enterprises, and the financing systems. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1498443DOI Listing
October 2018
12 Reads

Current state and prospects of biotechnology in Central and Eastern European countries. Part I: Visegrad countries (CZ, H, PL, SK).

Crit Rev Biotechnol 2018 Oct 29:1-23. Epub 2018 Oct 29.

b Faculty of Natural Sciences, Department of Biotechnology , University of SS. Cyril and Methodius in Trnava , Trnava , Slovakia.

Innovation is a key determinant of sustainable growth. Biotechnology (BT) is one such industry that has witnessed a revolution in innovative ideas leading to the founding of many new companies based on providing products, solutions and services, stretching from the food industry to environmental remediation, and new medicines. BT holds much promise for the development of national and local economies, however, this requires a strategic approach involving actors within government, industry, and academia working in concert to maximize this potential. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1523131DOI Listing
October 2018
20 Reads

Recent developments in colorimetric immunoassays using nanozymes and plasmonic nanoparticles.

Crit Rev Biotechnol 2018 Sep 9:1-17. Epub 2018 Sep 9.

a Biosensors and Biotechnology Laboratory, Integrated Science Building, Faculty of Science , Universiti Brunei Darussalam , Jalan Tungku Link , Gadong , Brunei.

Enzyme-linked immunosorbent assay (ELISA) is a popular detection technique for the screening and diagnosis of diseases. The sensitivity of ELISA can be increased by the incorporation of nanoparticles. Through this article, we discuss the utilization of nanoparticles in ELISA. Read More

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http://dx.doi.org/10.1080/07388551.2018.1496063DOI Listing
September 2018
1 Read

Algal polysaccharides: potential bioactive substances for cosmeceutical applications.

Crit Rev Biotechnol 2018 Sep 9:1-15. Epub 2018 Sep 9.

a Department of Marine Life Science , Jeju National University , Jeju , Republic of Korea.

The cosmetics industry is one of the most profitable in the world today. This multi-billion-dollar industry has a profound sociological impact worldwide. Its influence is global, with most individuals being concerned with conserving their physical appearance, beauty, and youth. Read More

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http://dx.doi.org/10.1080/07388551.2018.1503995DOI Listing
September 2018
2 Reads

Bioremediation through microbes: systems biology and metabolic engineering approach.

Crit Rev Biotechnol 2018 Sep 9:1-20. Epub 2018 Sep 9.

a Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology , Maharshi Dayanand University , Rohtak , India.

Today, environmental pollution is a serious problem, and bioremediation can play an important role in cleaning contaminated sites. Remediation strategies, such as chemical and physical approaches, are not enough to mitigate pollution problems because of the continuous generation of novel recalcitrant pollutants due to anthropogenic activities. Bioremediation using microbes is an eco-friendly and socially acceptable alternative to conventional remediation approaches. Read More

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http://dx.doi.org/10.1080/07388551.2018.1500997DOI Listing
September 2018
1 Read
7.180 Impact Factor

Global trends in research and commercialization of exogenous and endogenous RNAi technologies for crops.

Crit Rev Biotechnol 2019 Feb 9;39(1):67-78. Epub 2018 Sep 9.

a Centre for Research in Biotechnology for Agriculture, University of Malaya , Kuala Lumpur , Malaysia.

It has only been about 20 years since the first Nobel Prize-winning work on RNA interference (RNAi) in Caenorhabditis elegans was published in the journal Nature. Fast forward to today, and the use of RNA molecules as gene-silencing elements in crops has helped scientists to unveil possible solutions to the global problems of agricultural losses due to pests, viruses, pathogens, and to other abiotic and biotic stresses. The recent proliferation of publications suggests that the technology has gained significant attention and received ample funding support. Read More

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http://dx.doi.org/10.1080/07388551.2018.1496064DOI Listing
February 2019
1 Read
7.180 Impact Factor

Fathoming Aspergillus oryzae metabolomes in formulated growth matrices.

Crit Rev Biotechnol 2018 Jul 23:1-15. Epub 2018 Jul 23.

a Department of Bioscience and Biotechnology , Konkuk University , Seoul , Korea.

The stochasticity of Aspergillus oryzae (Trivially: the koji mold) pan-metabolomes commensurate with its ubiquitously distributed landscapes, i.e. growth matrices have been seemed uncharted since its food fermentative systems are mostly being investigated. Read More

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http://dx.doi.org/10.1080/07388551.2018.1490246DOI Listing
July 2018
4 Reads

VOCs-mediated hormonal signaling and crosstalk with plant growth promoting microbes.

Crit Rev Biotechnol 2018 Dec 3;38(8):1277-1296. Epub 2018 Jun 3.

b Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology , Maharshi Dayanand University , Rohtak , India.

In the natural environment, plants communicate with various microorganisms (pathogenic or beneficial) and exhibit differential responses. In recent years, research on microbial volatile compounds (MVCs) has revealed them to be simple, effective and efficient groups of compounds that modulate plant growth and developmental processes. They also interfere with the signaling process. Read More

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http://dx.doi.org/10.1080/07388551.2018.1472551DOI Listing
December 2018
7 Reads
7.180 Impact Factor

Research progress on distribution, migration, transformation of antibiotics and antibiotic resistance genes (ARGs) in aquatic environment.

Crit Rev Biotechnol 2018 Dec 28;38(8):1195-1208. Epub 2018 May 28.

a School of Environment and Energy , South China University of Technology, Guangzhou Higher Education Mega Centre , Guangzhou , PR China.

Antimicrobial and antibiotics resistance caused by misuse or overuse of antibiotics exposure is a growing and significant threat to global public health. The spread and horizontal transfer of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) by the selective pressure of antibiotics in an aquatic environment is a major public health issue. To develop a better understanding of potential ecological risks die to antibiotics and ARGs, this study mainly summarizes research progress about: (i) the occurrence, concentration, fate, and potential ecological effects of antibiotics and ARGs in various aquatic environments, (ii) the threat, spread, and horizontal gene transfer (HGT) of ARGs, and (iii) the relationship between antibiotics, ARGs, and ARB. Read More

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http://dx.doi.org/10.1080/07388551.2018.1471038DOI Listing
December 2018
3 Reads

A potential biotechnological process for the sustainable production of vitamin K.

Crit Rev Biotechnol 2018 May 24:1-19. Epub 2018 May 24.

a School of Chemical and Biomolecular Engineering , University of Sydney , Sydney , NSW , Australia.

The primary objective of this review is to propose an approach for the biosynthesis of phylloquinone (vitamin K) based upon its known sources, its role in photosynthesis and its biosynthetic pathway. The chemistry, health benefits, market, and industrial production of vitamin K are also summarized. Vitamin K compounds (K vitamers) are required for the normal function of at least 15 proteins involved in diverse physiological processes such as coagulation, tissue mineralization, inflammation, and neuroprotection. Read More

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http://dx.doi.org/10.1080/07388551.2018.1474168DOI Listing
May 2018
6 Reads

Nutrient removal and biomass production: advances in microalgal biotechnology for wastewater treatment.

Crit Rev Biotechnol 2018 Dec 17;38(8):1244-1260. Epub 2018 May 17.

a Global Centre for Environmental Remediation (GCER), Research and Innovation Division, Faculty of Science , University of Newcastle , Callaghan , Australia.

Owing to certain drawbacks, such as energy-intensive operations in conventional modes of wastewater treatment (WWT), there has been an extensive search for alternative strategies in treatment technology. Biological modes for treating wastewaters are one of the finest technologies in terms of economy and efficiency. An integrated biological approach with chemical flocculation is being conventionally practiced in several-sewage and effluent treatment plants around the world. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1472066DOI Listing
December 2018
6 Reads

Insight into carrageenases: major review of sources, category, property, purification method, structure, and applications.

Crit Rev Biotechnol 2018 Dec 15;38(8):1261-1276. Epub 2018 May 15.

c Institute of Process Engineering , Chinese Academy of Sciences , Beijing , PR China.

Carrageenan, a kind of linear sulfated polysaccharides consisting of D-galactose with alternating α-1,3 and β-1,4 linkages, has been widely applied in the food and cosmetic industries as thickening and gelling agents due to excellent properties, such as gel-forming ability and chemical stability. It can be degraded by carrageenases to produce a series of even-numbered carrageenan oligosaccharides, which exhibit various fascinating functions, such as anti-inflammation, anti-coagulation, anti-tumor, and anti-thrombosis effects. Numerous carrageenases have been isolated and identified from various sources. Read More

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http://dx.doi.org/10.1080/07388551.2018.1472550DOI Listing
December 2018
8 Reads

Production of oils and fats by oleaginous microorganisms with an emphasis given to the potential of the nonconventional yeast Yarrowia lipolytica.

Crit Rev Biotechnol 2018 Dec 15;38(8):1230-1243. Epub 2018 May 15.

a Cukurova University , Faculty of Agriculture, Food Engineering Department , Adana , Turkey.

Recently, there has been a great upsurge of interest in studies related to several aspects of microbial lipid production, which is one of the top topics in relevant research fields due to the high demand of these fatty materials in food, medical, oleochemical and biofuel industries. Lipid accumulation by the so-called "oleaginous microorganisms" can generate more than 20% w/w of oil in dry biomass and is governed by a plethora of parameters, such as medium pH, incubation temperature, nutrient limitation and C/N (carbon/nitrogen) ratio, which drastically affect the lipid production bioprocess. Until now, considerable work has been undertaken to find the cheapest substrate to enable lipid fermentation by oleaginous microorganisms. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1472065DOI Listing
December 2018
15 Reads

Biotechnological potential of microbial consortia and future perspectives.

Crit Rev Biotechnol 2018 Dec 15;38(8):1209-1229. Epub 2018 May 15.

a Department of Biological Engineering, College of Engineering , Konkuk University , Seoul , South Korea.

Design of a microbial consortium is a newly emerging field that enables researchers to extend the frontiers of biotechnology from a pure culture to mixed cultures. A microbial consortium enables microbes to use a broad range of carbon sources. It provides microbes with robustness in response to environmental stress factors. Read More

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http://dx.doi.org/10.1080/07388551.2018.1471445DOI Listing
December 2018
4 Reads

Glucuronoyl esterases: diversity, properties and biotechnological potential. A review.

Crit Rev Biotechnol 2018 Nov 8;38(7):1121-1136. Epub 2018 May 8.

b Institute of Chemistry, Slovak Academy of Sciences , Bratislava , Slovak Republic.

Glucuronoyl esterases (GEs) belonging to the carbohydrate esterase family 15 (CE15) are involved in microbial degradation of lignocellulosic plant materials. GEs are capable of degrading complex polymers of lignin and hemicellulose cleaving ester bonds between glucuronic acid residues in xylan and lignin alcohols. GEs promote separation of lignin, hemicellulose and cellulose which is crucial for efficient utilization of biomass as an energy source and feedstock for further processing into products or chemicals. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1468316DOI Listing
November 2018
9 Reads

Metabolomics assisted metabolic network modeling and network wide analysis of metabolites in microbiology.

Crit Rev Biotechnol 2018 Nov 22;38(7):1106-1120. Epub 2018 Apr 22.

a Key Laboratory of Systems Bioengineering (Ministry of Education) , Tianjin University , Tianjin , People's Republic of China.

Metabolomics is the science of qualitatively and quantitatively analyzing low molecular weight metabolites occur in a given biological system. It provides valuable information to elucidate the functional roles and relations of different metabolites in a metabolic pathway. In recent years, a large amount of research on microbial metabolomics has been conducted. Read More

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http://dx.doi.org/10.1080/07388551.2018.1462141DOI Listing
November 2018
41 Reads

Carbon, nitrogen and phosphorus removal mechanisms of aerobic granules.

Crit Rev Biotechnol 2018 Nov 10;38(7):1077-1088. Epub 2018 Apr 10.

b Department of Civil Engineering, Schulich School of Engineering , University of Calgary , Calgary , Canada.

Aerobic granules are the potential tools to develop modern wastewater treatment technologies with improved nutrient removal efficiency. These granules have several promising advantages over conventional activated sludge-based wastewater treatment processes. This technology has the potential of reducing the infrastructure and operation costs of wastewater treatment by 25%, energy requirement by 30%, and space requirement by 75%. Read More

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http://dx.doi.org/10.1080/07388551.2018.1451481DOI Listing
November 2018
5 Reads

Transformation of animal genomics by next-generation sequencing technologies: a decade of challenges and their impact on genetic architecture.

Crit Rev Biotechnol 2018 Dec 10;38(8):1157-1175. Epub 2018 Apr 10.

a Department of Animal Biotechnology , Jeju National University , Jeju-Do , Republic of Korea.

For more than a quarter of a century, sequencing technologies from Sanger's method to next-generation high-throughput techniques have provided fascinating opportunities in the life sciences. The continuing upward trajectory of sequencing technologies will improve livestock research and expedite the development of various new genomic and technological studies with farm animals. The use of high-throughput technologies in livestock research has increased interest in metagenomics, epigenetics, genome-wide association studies, and identification of single nucleotide polymorphisms and copy number variations. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1451819DOI Listing
December 2018
25 Reads

Bioflocculation in natural and engineered systems: current perspectives.

Crit Rev Biotechnol 2018 Dec 10;38(8):1176-1194. Epub 2018 Apr 10.

a Cell Factory Research Center , Korea Research Institute of Bioscience and Biotechnology , Daejeon , Republic of Korea.

Microorganisms have the tendency to accumulate at interfaces through the release of extracellular polymeric substances to form aggregates such as films or flocs. This physical association leads to different modes of interactions among cells and the subsequent development of functionally and metabolically diverse consortia. Aggregation of cells in aqueous suspensions often results in the formation of flocs, which are hotspots of enhanced microbial processes. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1
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http://dx.doi.org/10.1080/07388551.2018.1451984DOI Listing
December 2018
7 Reads
7.180 Impact Factor

Engineering microbes for direct fermentation of cellulose to bioethanol.

Crit Rev Biotechnol 2018 Nov 10;38(7):1089-1105. Epub 2018 Apr 10.

c Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology , Maharshi Dayanand University , Rohtak , India.

Consolidated bioprocessing (CBP) by micro-organisms is desired for efficient conversion of lignocellulosic biomass to bioethanol fuels. Potential candidates have been discovered, including cellulolytic bacteria and filamentous fungi. Genetic and metabolic manipulation of these organisms further promotes their fermentation capacities and the ethanol tolerance. Read More

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http://dx.doi.org/10.1080/07388551.2018.1452891DOI Listing
November 2018
41 Reads
1 Citation
7.180 Impact Factor

Exploiting mAb structure characteristics for a directed QbD implementation in early process development.

Crit Rev Biotechnol 2018 Sep 7;38(6):957-970. Epub 2018 Mar 7.

a School of Chemical Engineering and Advanced Materials , Newcastle University , Newcastle upon Tyne , UK.

In today's biopharmaceutical industries, the lead time to develop and produce a new monoclonal antibody takes years before it can be launched commercially. The reasons lie in the complexity of the monoclonal antibodies and the need for high product quality to ensure clinical safety which has a significant impact on the process development time. Frameworks such as quality by design are becoming widely used by the pharmaceutical industries as they introduce a systematic approach for building quality into the product. Read More

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http://dx.doi.org/10.1080/07388551.2017.1421899DOI Listing
September 2018
10 Reads

Ultra-sonication application in biodiesel production from heterotrophic oleaginous microorganisms.

Crit Rev Biotechnol 2018 Sep 6;38(6):902-917. Epub 2018 Mar 6.

a School of Civil and Environmental Engineering , Harbin Institute of Technology (Shenzhen) , Shenzhen , Guangdong , P.R. China.

Utilization of microbial oil for biodiesel production has gained growing interest due to the increase in prices and the shortage of the oils and fats traditionally used in biodiesel production. However, it is still in the laboratory study stage due to the high cost of production. Employing organic wastes as raw materials to grow heterotrophic oleaginous microorganisms for further lipid production to produce biodiesel has been predicted to be a promising method for reducing costs. Read More

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http://dx.doi.org/10.1080/07388551.2017.1418733DOI Listing
September 2018
7 Reads

Stability of biogenic metal(loid) nanomaterials related to the colloidal stabilization theory of chemical nanostructures.

Crit Rev Biotechnol 2018 Dec 25;38(8):1137-1156. Epub 2018 Feb 25.

a Microbial Biochemistry Laboratory, Department of Biological Sciences , University of Calgary , Calgary , Canada.

In the last 15 years, the exploitation of biological systems (i.e. plants, bacteria, mycelial fungi, yeasts, and algae) to produce metal(loid) (Me)-based nanomaterials has been evaluated as eco-friendly and a cost-effective alternative to the chemical synthesis processes. Read More

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http://dx.doi.org/10.1080/07388551.2018.1440525DOI Listing
December 2018
8 Reads

NADPH metabolism: a survey of its theoretical characteristics and manipulation strategies in amino acid biosynthesis.

Crit Rev Biotechnol 2018 Nov 25;38(7):1061-1076. Epub 2018 Feb 25.

a The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology , Jiangnan University , WuXi , PR China.

Reduced nicotinamide adenine nucleotide phosphate (NADPH), which is one of the key cofactors in the metabolic network, plays an important role in the biochemical reactions, and physiological function of amino acid-producing strains. The manipulation of NADPH availability and form is an efficient and easy method of redirecting the carbon flux to the amino acid biosynthesis in industrial strains. In this review, we survey the metabolic mode of NADPH. Read More

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http://dx.doi.org/10.1080/07388551.2018.1437387DOI Listing
November 2018
14 Reads

Various physicochemical and surface properties controlling the bioactivity of cerium oxide nanoparticles.

Crit Rev Biotechnol 2018 Nov 5;38(7):1003-1024. Epub 2018 Feb 5.

a Department of Food Science , Fu Jen Catholic University , New Taipei City , Taiwan.

Amidst numerous emerging nanoparticles, cerium oxide nanoparticles (CNPs) possess fascinating pharmacological potential as they can be used as a therapeutic for various oxidative stress-associated chronic diseases such as cancer, inflammation and neurodegeneration due to unique redox cycling between Ce and Ce oxidation states on their surface. Lattice defects generated by the formation of Ce ions and compensation by oxygen vacancies on CNPs surface has led to switching between CeO and CeO during redox reactions making CNPs a lucrative catalytic nanoparticle capable of mimicking key natural antioxidant enzymes such as superoxide dismutase and catalase. Eventually, most of the reactive oxygen species and nitrogen species in biological system are scavenged by CNPs via an auto-regenerative mechanism in which a minimum dose can exhibit catalytic activity for a longer duration. Read More

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http://dx.doi.org/10.1080/07388551.2018.1426555DOI Listing
November 2018
6 Reads

Integration of aerobic granular sludge and membrane bioreactors for wastewater treatment.

Crit Rev Biotechnol 2018 Sep 4;38(6):801-816. Epub 2018 Feb 4.

a Division of Water Environment Technology, Department of Architecture and Civil Engineering , Chalmers University of Technology , Gothenburg , Sweden.

Environmental deterioration together with the need for water reuse and the increasingly restrictive legislation of water quality standards have led to a demand for compact, efficient and less energy consuming technologies for wastewater treatment. Aerobic granular sludge and membrane bioreactors (MBRs) are two technologies with several advantages, such as small footprint, high-microbial density and activity, ability to operate at high organic- and nitrogen-loading rates, and tolerance to toxicity. However, they also have some disadvantages. Read More

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http://dx.doi.org/10.1080/07388551.2017.1414140DOI Listing
September 2018
6 Reads

Fatty acids from oleaginous yeasts and yeast-like fungi and their potential applications.

Crit Rev Biotechnol 2018 Nov 1;38(7):1049-1060. Epub 2018 Feb 1.

a College of Marine Life Sciences , Ocean University of China , Qingdao , China.

Purpose: Oleaginous yeasts, fatty acids biosynthesis and regulation in the oleaginous yeasts and the fatty acids from the oleaginous yeasts and their applications are reviewed in this article.

Results: Oleaginous yeasts such as Rhodosporidium toruloides, Yarrowia lipolytica, Rhodotorula mucilaginosa, and Aureobasidium melanogenum, which can accumulate over 50% lipid of their cell dry weight, have many advantages over other oleaginous microorganisms. The fatty acids from the oleaginous yeasts have many potential applications. Read More

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http://dx.doi.org/10.1080/07388551.2018.1428167DOI Listing
November 2018
7 Reads
7.180 Impact Factor

Unraveling uncultivable pesticide degraders via stable isotope probing (SIP).

Crit Rev Biotechnol 2018 Nov 1;38(7):1025-1048. Epub 2018 Feb 1.

c Lancaster Environment Centre , Lancaster University , Lancaster , UK.

Uncultivable microorganisms account for over 99% of all species on earth, playing essential roles in ecological processes such as carbon/nitrogen cycle and chemical mineralization. Their functions remain unclear in ecosystems and natural habitats, requiring cutting-edge biotechnologies for a deeper understanding. Stable isotope probing (SIP) incorporates isotope-labeled elements, e. Read More

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http://dx.doi.org/10.1080/07388551.2018.1427697DOI Listing
November 2018
7 Reads
1 Citation
7.180 Impact Factor

Oxidoreductases for the remediation of organic pollutants in water - a critical review.

Crit Rev Biotechnol 2018 Nov 31;38(7):971-988. Epub 2018 Jan 31.

b Department of Chemistry , College of Science, UAE University , Al-Ain , UAE.

Water contamination by various recalcitrant organic aromatic compounds is an emerging environmental issue that is increasingly attracting the attention of environmental scientists. A great majority of these recalcitrant pollutants are industrial wastes, textile dyes, pharmaceuticals, hormones, and personal care products that are discharged into wastewater. Not surprisingly, various chemical, physical, and biological strategies have been proposed and developed to remove and/or degrade these pollutants from contaminated water bodies. Read More

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http://dx.doi.org/10.1080/07388551.2017.1423275DOI Listing
November 2018
7 Reads