767,878 results match your criteria Critical Care Nursing Clinics of North America[Journal]


The adoption of sustainable practices: A supplier's perspective.

J Environ Manage 2018 Dec 3;232:692-701. Epub 2018 Dec 3.

Chinese Academy of Environmental Planning, Beijing, China.

Suppliers' adoption of sustainable practices plays a critical role for global companies to improve environmental performance. Based on the absorptive capacity theory, this study empirically explores how suppliers' knowledge bases and power relationships influence their adoption of sustainability practices. A longitudinal case study with eight suppliers has been conducted. Read More

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December 2018
4 Reads

The effect of unilateral lingual nerve injury on the kinematics of mastication in pigs.

Arch Oral Biol 2018 Nov 22;98:226-237. Epub 2018 Nov 22.

Ohio University Heritage College of Osteopathic Medicine, Department of Biomedical Sciences, Irvine Hall 228, Athens, OH, 45701, USA. Electronic address:

Objective: This study evaluates the effect of unilateral lingual sensory loss on the spatial and temporal dynamics of jaw movements during pig chewing.

Design: X-ray Reconstruction of Moving Morphology (XROMM) was used to reconstruct the 3-dimensional jaw movements of 6 pigs during chewing before and after complete unilateral lingual nerve transection. The effect of the transection were evaluated at the temporal and spatial level using Multiple Analysis of Variance. Read More

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November 2018
1 Read

Quantifying streamflow response to climate variability, wastewater inflow, and sprawling urbanization in a heavily modified river basin.

Sci Total Environ 2018 Nov 23;656:458-467. Epub 2018 Nov 23.

Department of Hydrology, Faculty of Geography and Regional Studies, University of Warsaw, Krakowskie Przedmieście 30, 00-927 Warsaw, Poland. Electronic address:

Considering the growing recognition that human activity and climate variability are critical stressors influencing river regimes, there is an urgent need to identify the contribution of these fundamental factors. Here we examine the runoff changes of a wastewater-effluent dominated river flowing in a heavily modified urban environment. The study concerns the Utrata River basin (727 km), central Poland, a challenging human-natural system for investigating changes in hydrological processes. Read More

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November 2018

Elaboration of a thermosensitive smart biomaterial: From synthesis to the ex vivo bioadhesion evaluation.

Colloids Surf B Biointerfaces 2018 Nov 30;175:91-97. Epub 2018 Nov 30.

CIRIMAT, Université de Toulouse 3 - Paul Sabatier, CNRS, Toulouse, France. Electronic address:

Alginate and chitosan are polysaccharides that are widely used in the biomedical field, especially as wound dressings. Controlled bioadhesion is an advanced functionality that offers the potential to reduce injuries due to the stripping-off of the biomaterial. Herein, we report the efficient grafting of poly-N(isopropylacryamide) (PNIPAM), a thermosensitive polymer that exhibits a lower critical solution temperature (LCST) at 32 °C on the alginate/chitosan polyelectrolyte complex (PEC) surface. Read More

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November 2018
2 Reads

Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle.

Eur J Pharm Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands. Electronic address:

The aim of this study was to identify critical steps to protein stability during spray drying using two different nozzle types: a vibrating mesh nozzle and a standard two-fluid nozzle in a Büchi B-90 spray dryer. l-Lactic dehydrogenase was used as a model protein as it is a heat and shear stress sensitive protein. Trehalose was used as excipient because of its excellent stabilizing capacities. Read More

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December 2018

Implication of nigral dopaminergic lesion and repeated L-dopa exposure in neuropsychiatric symptoms of Parkinson's disease.

Behav Brain Res 2018 Dec 3. Epub 2018 Dec 3.

Biotrial Pharmacology, 7-9 rue Jean-Louis Bertrand, 35042, Rennes, France.

This study aims to investigate the contribution of nigral dopaminergic (DA) cell loss, repeated exposure to DA medication and the combination of both to the development of neuropsychiatric symptoms observed in Parkinson's disease (PD). A bilateral 6-OHDA lesion of the substantia nigra pars compacta (SNc) was performed in rats. A set of animals was repeatedly administered with L-dopa (20 mg/kg/day) and benserazide (5 mg/kg/day) over 10 days starting from day 11 post-lesion. Read More

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December 2018
1 Read

22kHz and 55kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat.

Behav Brain Res 2018 Dec 3. Epub 2018 Dec 3.

Developmental Neuropsychobiology Lab, Department of Psychology, Northeastern University, 360 Huntington Ave NI125, Boston, MA, 02115, United States. Electronic address:

The communicative role of ultrasonic vocalizations (USVs) in rats is well established, with distinct USVs indicative of different affective states. USVs in the 22 kHz range are typically emitted by adult rats when in anxiety- or fear-provoking situations (e.g. Read More

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December 2018

Influence of alkali treatment on physicochemical, pasting, morphological and structural properties of mango kernel starches derived from Indian cultivars.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Food Engineering and Technology, Sant Longowal Institute of Engineering and Technology, Longowal, Punjab, India. Electronic address:

Present investigation was aimed to characterize the influence of alkali treatment on physicochemical, pasting, morphological and structural properties of mango kernel starches from three cultivars viz. Safeda, Chausa, Dussheri when treated with 0.1, 0. Read More

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December 2018

Tuning store-operated calcium entry to modulate Ca-dependent physiological processes.

Biochim Biophys Acta Mol Cell Res 2018 Dec 3. Epub 2018 Dec 3.

Secretory Physiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

The intracellular calcium signaling processes are tightly regulated to ensure the generation of calcium signals with the specific spatiotemporal characteristics that are required for regulating various cell functions. Compartmentalization of the molecular components involved in generating these signals at discrete intracellular sites ensures the signaling specificity and transduction fidelity of the signal for regulating downstream effector processes. Store-operated calcium entry (SOCE) is ubiquitously present in cells and is critical for essential cell functions in a variety of tissues. Read More

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December 2018
5 Reads

Enhancing effects of acute exposure to cannabis smoke on working memory performance.

Neurobiol Learn Mem 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA; Department of Psychology, University of Florida, Gainesville, FL, USA. Electronic address:

Numerous preclinical studies show that acute cannabinoid administration impairs cognitive performance. Almost all of this research has employed cannabinoid injections, however, whereas smoking is the preferred route of cannabis administration in humans. The goal of these experiments was to systematically determine how acute exposure to cannabis smoke affects working memory performance in a rat model. Read More

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December 2018
4 Reads

Engineered Viral RNA Decay Intermediates to Assess XRN1-mediated decay.

Methods 2018 Dec 3. Epub 2018 Dec 3.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80525, United States; Program in Cell & Molecular Biology, Colorado State University, Fort Collins, CO 80525, United States. Electronic address:

Both RNA synthesis and decay must be balanced within a cell to achieve proper gene expression. Additionally, modulation of RNA decay specifically offers the cell an opportunity to rapidly reshape the transcriptome in response to specific stimuli or cues. Therefore, it is critical to understand the underlying mechanisms through which RNA decay contribute to gene expression homeostasis. Read More

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December 2018
1 Read

Metabolome-wide association study of anti-epileptic drug treatment during pregnancy.

Toxicol Appl Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States. Electronic address:

Pregnant women with epilepsy (PWWE) require continuous anti-epileptic drug (AED) treatment to avoid risk to themselves and fetal risks secondary to maternal seizures, resulting in prolonged AED exposure to the developing embryo and fetus. The objectives of this study were to determine whether high-resolution metabolomics is able to link the metabolite profile of PWWE receiving lamotrigine or levetiracetam for seizure control to associated pharmacodynamic (PD) biological responses. Untargeted metabolomic analysis of plasma obtained from 82 PWWE was completed using high-resolution mass spectrometry. Read More

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December 2018
4 Reads

Expression of the neuropeptides RFamide and LWamide during development of the coral Acropora millepora in relation to settlement and metamorphosis.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Division of Ecology and Evolution, Bldg 46, Research School of Biology, Australian National University, Canberra, ACT 0200, Australia; ARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, QLD 4811, Australia. Electronic address:

Neuropeptides play critical roles in cnidarian development. However, although they are known to play key roles in settlement and metamorphosis, their temporal and spatial developmental expression has not previously been characterized in any coral. We here describe Acropora millepora LWamide and RFamide and their developmental expression from the time of their first appearance, using in situ hybridization and FMRFamide immunohistochemistry. Read More

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December 2018
1 Read

Does Maternal Age at Retrieval Influence the Implantation Potential of Euploid Blastocysts?

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10021.

Background: Age-related decline in reproductive potential is mainly due to the increased incidence of aneuploidy. Furthermore, two recent studies have shown that euploid embryos of older women may have a lower implantation potential compared to those of younger women, suggesting that aging might compromise embryos beyond their ploidy status. However, the inherent limitations of these studies preclude solid conclusions. Read More

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December 2018
3 Reads

Comparison of electroencephalogram (EEG) response to MDPV versus the hallucinogenic drugs MK-801 and ketamine in rats.

Exp Neurol 2018 Dec 3. Epub 2018 Dec 3.

Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA. Electronic address:

Synthetic cathinones, often marketed as 'bath salts', have been reported to induce an excited delirium syndrome with characteristic symptoms such as paranoid, hallucination and even aggression. 3,4-Methylenedioxypyrovalerone (MDPV), a norepinephrine-dopamine reuptake inhibitor (NDRI), is one of the psychoactive ingredients in bath salts. The present study utilized cortical EEG and brain microdialysis in rats to compare the effects of MDPV (0. Read More

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December 2018

Carbon disulfide induces embryo loss by perturbing the expression of the mTOR signalling pathway in uterine tissue in mice.

Chem Biol Interact 2018 Dec 3. Epub 2018 Dec 3.

Department of Occupational and Environmental Health, School of Public Health, Shandong University, China. Electronic address:

Understanding of the mechanism of embryo loss is critical for successful pregnancy considering an increase in the incidence of infertility. In this study, we focus on the effect of alterations in the expression of the AKT/AMPK/mTOR signalling pathway in mouse uterine tissue after embryo loss induced by harmful environmental exposure to carbon disulfide (CS). CS is a material used in certain production processes, and women are sometimes exposed to it in occupational settings. Read More

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December 2018

A Path(way) to Keeping Your Synapses on an Even Keel.

Neuron 2018 Dec;100(5):1013-1014

Pathology and Laboratory Medicine, Weill Cornell Medicine, New York City, NY, USA.

In this issue of Neuron, Harris et al. (2018) show that a signal transduction pathway normally exploited by the innate immune system in recognizing foreign agents plays a critical role in controlling a synapse's ability to maintain stability in the efficacy of synaptic transmission over both rapid and prolonged timescales. Read More

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December 2018
2 Reads

Electronic "Sniffer" Systems to Identify the Acute Respiratory Distress Syndrome: A Systematic Review.

Ann Am Thorac Soc 2018 Dec 6. Epub 2018 Dec 6.

University of Michigan, Internal Medicine, Ann Arbor, Michigan, United States ;

Background: The acute respiratory distress syndrome (ARDS) results in substantial mortality but remains underdiagnosed in clinical practice. Automated ARDS "sniffer" systems, tools that can automatically analyze electronic medical record data, have been developed to improve recognition of ARDS in clinical practice.

Objective: To perform a systematic review examining the evidence underlying automated sniffer systems for ARDS detection. Read More

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December 2018

Identification and Modulation of Microenvironment is Crucial for Effective MSC Therapy in Acute Lung Injury.

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Critical Care Medicine, Guangzhou, Guangdong, China.

Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS).

Objective: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS.

Methods: Lung proteome was profiled in three models of injury induced by acid instillation and/or mechanical ventilation in mice. Read More

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December 2018
2 Reads

Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner?

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

Johns Hopkins University, Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States ;

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December 2018

Solriamfetol for Excessive Sleepiness in Obstructive Sleep Apnea (TONES 3): A Randomized Controlled Trial.

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

Case Western Reserve University, Cleveland, Ohio, United States.

Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic options for the treatment of sleepiness in this population are limited. Read More

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December 2018

Controlling the Activity and Stability of Electrochemical Interfaces Using Atom-by-Atom Metal Substitution of Redox Species.

ACS Nano 2018 Dec 6. Epub 2018 Dec 6.

Understanding the molecular-level properties of electrochemically-active ions at operating electrode-electrolyte interfaces (EEI) is key to the rational development of high-performance nanostructured surfaces for applications in energy technology. Herein, an electrochemical cell coupled with ion soft landing is employed to examine the effect of "atom-by-atom" metal substitution on the activity and stability of well-defined redox-active anions, PMoWO (x = 0,1,2,3,6,9,12), at nanostructured ionic liquid EEI. A striking observation made by in situ electrochemical measurements and further supported by theoretical calculations is that substitution of only (1-3) tungsten by molybdenum atoms in the PWO anions results in a substantial spike in their first reduction potential. Read More

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December 2018
1 Read

Ligand density and linker length are critical factors for multivalent nanoparticle-receptor interactions.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Although there is a large number of studies available evaluating the therapeutic efficacy of targeted polymeric nanoparticles, little is known about the critical attributes that can further influence their uptake into target cells. In this study, varying cRGD ligand densities (0-100% surface functionalization) were combined with different PEG spacer lengths (2/3.5/5kDa) and the specific receptor binding of targeted core-shell structured PLGA/PLA-PEG nanoparticles was evaluated using αβ integrin overexpressing U87MG glioblastoma cells. Read More

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December 2018
1 Read

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

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November 2018
6 Reads

Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis.

Cochrane Database Syst Rev 2018 Dec 3;12:CD012620. Epub 2018 Dec 3.

Division of Pulmonary and Critical Care Medicine, University of Missouri, Columbia, MO, USA.

Background: Long-acting bronchodilators such as long-acting β-agonist (LABA), long-acting muscarinic antagonist (LAMA), and LABA/inhaled corticosteroid (ICS) combinations have been used in people with moderate to severe chronic obstructive pulmonary disease (COPD) to control symptoms such as dyspnoea and cough, and prevent exacerbations. A number of LABA/LAMA combinations are now available for clinical use in COPD. However, it is not clear which group of above mentioned inhalers is most effective or if any specific formulation works better than the others within the same group or class. Read More

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December 2018
2 Reads

Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD011901. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is important to guide appropriate management, to reduce morbidity and to improve survival. Basal cell carcinoma (BCC) is almost always a localised skin cancer with potential to infiltrate and damage surrounding tissue, whereas a minority of cutaneous squamous cell carcinomas (cSCCs) and invasive melanomas are higher-risk skin cancers with the potential to metastasise and cause death. Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings. Read More

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December 2018
3 Reads

Visual inspection for diagnosing cutaneous melanoma in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013194. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. History-taking and visual inspection of a suspicious lesion by a clinician is usually the first in a series of 'tests' to diagnose skin cancer. Read More

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December 2018
4 Reads

Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD011902. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion by a clinician are usually the first in a series of 'tests' to diagnose skin cancer, dermoscopy has become an important tool to assist diagnosis by specialist clinicians and is increasingly used in primary care settings. Read More

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December 2018
6 Reads

CCR5 structural plasticity shapes HIV-1 phenotypic properties.

PLoS Pathog 2018 Dec 6;14(12):e1007432. Epub 2018 Dec 6.

Viral Pathogenesis Unit, Department of Virology, Institut Pasteur, Paris, France.

CCR5 plays immune functions and is the coreceptor for R5 HIV-1 strains. It exists in diverse conformations and oligomerization states. We interrogated the significance of the CCR5 structural diversity on HIV-1 infection. Read More

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December 2018
1 Read

Accuracy of Calcium Scoring calculated from contrast-enhanced Coronary Computed Tomography Angiography using a dual-layer spectral CT: A comparison of Calcium Scoring from real and virtual non-contrast data.

PLoS One 2018 6;13(12):e0208588. Epub 2018 Dec 6.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Purpose: Modern non-invasive evaluation of Coronary Artery Disease (CAD) requires non-contrast low dose Computed Tomography (CT) imaging for determination of Calcium Scoring (CACS) and contrast-enhanced imaging for evaluation of vascular stenosis. Several methods for calculation of CACS from contrast-enhanced images have been proposed before. The main principle for that is generation of virtual non-contrast images by iodine subtraction from a contrast-enhanced spectral CT dataset. Read More

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December 2018
1 Read

Assessing the role of the T-box transcription factor Eomes in B cell differentiation during either Th1 or Th2 cell-biased responses.

PLoS One 2018 6;13(12):e0208343. Epub 2018 Dec 6.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

Successful T-dependent humoral responses require the production of antibody-secreting plasmablasts, as well as the formation of germinal centers which eventually form high-affinity B cell memory. The ability of B cells to differentiate into germinal center and plasma cells, as well as the ability to tailor responses to different pathogens, is driven by transcription factors. In T cells, the T-box transcription factors T-bet and Eomesodermin (Eomes) regulate effector and memory T cell differentiation, respectively. Read More

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December 2018

Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.

PLoS One 2018 6;13(12):e0208321. Epub 2018 Dec 6.

Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, New York, United States of America.

Increased proinflammatory interleukin-6 (IL-6) levels are associated with acquired long QT-syndrome (LQTS) in patients with systemic inflammation, leading to higher risks for life-threatening polymorphic ventricular tachycardia such as Torsades de Pointes. However, the functional and molecular mechanisms of this association are not known. In most cases of acquired LQTS, the target ion channel is the human ether-á-go-go-related gene (hERG) encoding the rapid component of the delayed rectifier K current, IKr, which plays a critical role in cardiac repolarization. Read More

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December 2018
1 Read

An evaluation roadmap for critical quality attributes from tier 1 in analytical similarity assessment.

PLoS One 2018 6;13(12):e0208354. Epub 2018 Dec 6.

Department of Health Statistics, Fourth Military Medical University, Xi'an, Shannxi, China.

Analytical similarity assessment of critical quality attributes (CQAs) serves as a foundation for the development of biosimilar products and facilitates an abbreviated subsequent clinical evaluation. In this study, we establish a statistical evaluation roadmap with statistical approaches for some selected CQAs from Tier 1, because they are most relevant to clinical outcomes and require the most rigorous statistical methods. In the roadmap, we incorporate 3 methods-ranking and tier assignment of quality attributes, the equivalence test, and the Mann-Whitney test for equivalence-that are important to determine analytical similarity between the reference and biosimilar products. Read More

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December 2018
1 Read

A comparison of maternal and newborn health services costs in Sindh Pakistan.

PLoS One 2018 6;13(12):e0208299. Epub 2018 Dec 6.

Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.

Pakistani women suffer the highest rate of maternal mortality in South Asia. A lack of comprehensive knowledge about maternal and newborn health (MNH) services costs impedes policy decisions to maximize the benefit from existing, as well as emerging, MNH interventions in Pakistan. We compared MNH service costs at different levels of care. Read More

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December 2018
2 Reads

Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds.

PLoS Genet 2018 Dec 6;14(12):e1007850. Epub 2018 Dec 6.

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA, United States of America.

Domestic dog breeds exhibit remarkable morphological variations that result from centuries of artificial selection and breeding. Identifying the genetic changes that contribute to these variations could provide critical insights into the molecular basis of tissue and organismal morphogenesis. Bulldogs, French Bulldogs and Boston Terriers share many morphological and disease-predisposition traits, including brachycephalic skull morphology, widely set eyes and short stature. Read More

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December 2018
5 Reads

Citizen Social Lab: A digital platform for human behavior experimentation within a citizen science framework.

PLoS One 2018 6;13(12):e0207219. Epub 2018 Dec 6.

Departament d'Enginyeria Informàtica i Matemàtiques, Universitat Rovira i Virgili, Tarragona, Spain.

Cooperation is one of the behavioral traits that define human beings, however we are still trying to understand why humans cooperate. Behavioral experiments have been largely conducted to shed light into the mechanisms behind cooperation-and other behavioral traits. However, most of these experiments have been conducted in laboratories with highly controlled experimental protocols but with limitations in terms of subject pool or decisions' context, which limits the reproducibility and the generalization of the results obtained. Read More

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December 2018
2 Reads

Validity and measurement invariance across sex, age, and education level of the French short versions of the European Health Literacy Survey Questionnaire.

PLoS One 2018 6;13(12):e0208091. Epub 2018 Dec 6.

Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.

Background: Short versions of the European Health Literacy Survey (HLS-EU) questionnaire are increasingly used to measure and compare health literacy (HL) in populations worldwide. As no validated versions of these questionnaires have thus far appeared in French, this study aimed to study the psychometric properties of the French translation of the 16- and 6-item short versions (HLS-EU-Q16 and HLS-EU-Q6), including their measurement invariance across sex, age, and education level.

Methods: A consensual French version of the HLS-EU-Q16 and HLS-EU-Q6 was developed by following the current recommendations for transcultural questionnaire adaptation. Read More

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December 2018
1 Read

Molecular epidemiology of HIV-1 infection among men who have sex with men in Taiwan from 2013 to 2015.

PLoS One 2018 6;13(12):e0202622. Epub 2018 Dec 6.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.

Men who have sex with men (MSM) is the major risk population of HIV-1 infection in Taiwan, and its surveillance has become critical in HIV-1 prevention. We recruited MSM subjects from 17 high-risk venues and 4 community centers in northern and southern Taiwan for anonymous HIV-1 screening during 2013-2015. Blood samples were obtained for genotyping and phylogenetic analysis, and a questionnaire survey covering demographic variables and social behavior was conducted. Read More

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December 2018
1 Read

3D surface condensation of large atomic shear strain in nanoscale metallic glasses under low uniaxial stress.

J Phys Condens Matter 2019 Jan;31(2):025401

Materials Science Program, School of Mechanical, Industrial and Manufacturing Engineering, Oregon State University, Corvallis, OR 97331, United States of America.

Nanoscale metallic glasses (MGs) are frequently used in experimental and computational studies to probe the deformation mechanisms in amorphous metals. Potential consequences of the significant surface to volume ratio in these extremely small materials, nevertheless, are not well understood. Here, using molecular dynamics simulations and novel selective 3D visualization, we show that significant irreversible atomic shear strain condenses on the 3D surface of these materials under low uniaxial stress, while the interior atoms are bearing much lower, mostly reversible shear strain. Read More

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January 2019

An update of cyclooxygenase (COX)-inhibitors in epilepsy disorders.

Authors:
Ashish Dhir

Expert Opin Investig Drugs 2018 Dec 6. Epub 2018 Dec 6.

a Department of Neurology , School of Medicine, University of California Davis , Sacramento , CA , USA.

Introduction: Neuroinflammation has a critical role in brain disorders. Cyclooxygenase (COX) is one of the principal drug targets for the reduction of neuroinflammation; however, studies have yielded mixed results for COX-inhibitors in the treatment of diverse acute and chronic models of epilepsy. Areas covered: The article covers the effects of COX-inhibitors in epilepsy disorders. Read More

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December 2018
1 Read

Workload and Performance: Associations, Insensitivities, and Dissociations.

Hum Factors 2018 Dec 6:18720818809590. Epub 2018 Dec 6.

University of Central Florida, Orlando.

Objective:: The aim of this study was to distill and define those influences under which change in objective performance level and the linked cognitive workload reflections of subjective experience and physiological variation either associate, dissociate, or are insensitive, one to another.

Background:: Human factors/ergonomics frequently employs users' self-reports of their own conscious experience, as well as their physiological reactivity, to augment the understanding of changing performance capacity. Under some circumstances, these latter workload responses are the only available assessment information to hand. Read More

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December 2018
3 Reads

Infection control in the community.

Authors:
Ray Higginson

Br J Community Nurs 2018 Dec;23(12):590-595

Senior Lecturer in Critical Care Physiology, University of South Wales.

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December 2018

Trained murine mesenchymal stem cells have anti-inflammatory effect on macrophages, but defective regulation on T-cell proliferation.

FASEB J 2018 Dec 6:fj201801845R. Epub 2018 Dec 6.

Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, California, USA; and.

Mesenchymal stem cell (MSC)-mediated immunomodulation affects both innate and adaptive immune systems. These responses to environmental cues, such as pathogen-associated molecular patterns, damage-associated molecular patterns, or proinflammatory cytokines, are crucial for resolution of inflammation, as well as successful tissue healing and regeneration. We observed that intermittent, repeated exposure of MSCs to LPS induced stronger NF-κB activation than singular stimulation. Read More

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December 2018

Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs.

FASEB J 2018 Dec 6:fj201800981R. Epub 2018 Dec 6.

Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

As mechanisms controlling redox homeostasis become impaired with aging, exaggerated oxidant stress may cause disproportional oxidation of cell membranes and circulating phospholipids (PLs), leading to the formation of truncated oxidized PL products (Tr-OxPLs), which exhibit deleterious effects. This study investigated the role of elevated Tr-OxPLs as a factor exacerbating inflammation and lung barrier dysfunction in an animal model of aging. Mass spectrometry analysis of Tr-OxPL species in young (2-4 mo) and aging (18-24 mo) mice revealed elevated basal levels of several products [1-palmitoyl-2-(5-oxovaleroyl)- sn-glycero-phosphocholine (POVPC), 1-palmitoyl-2-glutaroyl- sn-glycero-phosphocholine, lysophosphocholine, 1-palmitoyl-2-(9-oxo-nonanoyl)- sn-glycero-3-phosphocholine, 1-palmitoyl-2-azelaoyl- sn-glycero-3-phosphocholine, O-1-O-palmitoyl-2-O-(5,8-dioxo-8-hydroxy-6-octenoyl)-l-glycero-3-phosphocholine, and others] in the aged lungs. Read More

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December 2018
2 Reads

Asthma Information Seeking via Wikipedia Between 2015 and 2018: Implications for Awareness Promotion.

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

Emory University, Department of Anesthesiology, Atlanta, Georgia, United States.

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December 2018

Chromatin Modifications in Toxicology.

Authors:
James J Galligan

Chem Res Toxicol 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , Tucson , Arizona 85721 , United States.

Histone modifications regulate chromatin structure and function. Primary and secondary metabolites stemming from environmental and chemical exposures may play a critical role in the underlying epigenomic state of a cell through covalent histone modifications. Future investigations should be focused on characterizing the "Histone Code" when performing toxicogenomic analyses. Read More

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December 2018
1 Read
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