6,875 results match your criteria Craniosynostosis


Anterior Cranial Vault Reconstruction With Distraction for Primary and Secondary Craniosynostosis Repair.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Division of Plastic and Reconstructive Surgery, University of Nebraska Medical Center, Omaha, NE.

Traditional fronto-orbital advancement continues to be a useful operation for correction of craniosynostosis involving the coronal or metopic sutures. Recently, distraction osteogenesis has been used to correct a variety of cranial deformities. Studies have mostly focused on posterior vault distraction due to its simplicity and greater volume gain when compared with anterior vault distraction. Read More

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November 2018

Wider Suturectomy Before Posterior Distraction for Craniosynostosis.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Plastic Surgery, Osaka Medical College.

The aim of the surgery for craniosynostosis is to release increased intracranial pressure and to normalize cranial shape. The procedure has developed so far in Japan, from a simple strip craniectomy before 1960s through a total calvarial remodeling after 1970s and later methods of 1990s, such as distraction and its modifications applying to the posterior cranium. Since a distracter needs certain hardness and thickness of the bone, the surgery has to be stood by until 5 to 6 months of age. Read More

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November 2018

Results and limits of posterior cranial vault expansion by osteotomy and internal distractors.

Surg Neurol Int 2018 30;9:217. Epub 2018 Oct 30.

Craniofacial Unit, Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Paris, France.

Background: Expanding the posterior cranial vault has become a common procedure in the treatment of complex craniosynostosis. Several techniques are available to remodel the posterior vault. Aim of this study was to analyze the posterior vault distraction osteogenesis. Read More

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October 2018

Surgical Correction of Unicoronal Craniosynostosis with Frontal Bone Symmetrization and Staggered Osteotomies.

Plast Surg Int 2018 29;2018:3793592. Epub 2018 Oct 29.

Assistant Professor of General Surgery, Iran University of Medical Sciences, Tehran, Iran.

Background: Craniosynostosis is the premature fusion of one or more cranial sutures that produce abnormal head shape. Plagiocephaly is a general term that describes unilateral flattening of the anterior or posterior quarter of the cranium. Anterior plagiocephaly is almost always due to unilateral coronal synostosis. Read More

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October 2018

Improvement of bone microarchitecture parameters after 12 months of treatment with asfotase alfa in adult patient with hypophosphatasia: Case report.

Medicine (Baltimore) 2018 Nov;97(48):e13210

Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Rationale: Hypophosphatasia is an inborn error of metabolism that can appear any time in life, mainly with bone manifestations due to low alkaline phosphatase activity. Asfotase alfa is a specific enzyme reposition treatment that has shown promising results in children; however, there are few reports about the outcomes in adult patients.

Patient Concerns: A 36-year-old male presented with an early history of craniosynostosis, short stature, and multiple fractures since the age of 13 years-which needed numerous surgical corrections. Read More

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November 2018
1 Read

A unique case of CHARGE syndrome with craniosynostosis.

Childs Nerv Syst 2018 Nov 29. Epub 2018 Nov 29.

Neuroradiology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

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November 2018
1 Read

Reliable manifestations of increased intracranial pressure in patients with syndromic craniosynostosis.

J Craniomaxillofac Surg 2018 Nov 12. Epub 2018 Nov 12.

Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Purpose: Systematic examination of increased intracranial pressure (ICP) is important during the follow-up period after surgical repair of syndromic craniosynostosis. In these patients, postoperative progress can be unclear due to the involvement of multiple sutures and the high incidence of relapse due to the progressive nature of the disease and to genetic variability. In this study, we investigated the clinical manifestations of increased ICP in syndromic craniosynostosis patients before and after surgery. Read More

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November 2018

Cranio-Maxillofacial and Dental Findings in Albright's Hereditary Osteodystrophy and Pseudohypoparathyroidism.

Cleft Palate Craniofac J 2018 Nov 29:1055665618814661. Epub 2018 Nov 29.

1 Oral and Maxillofacial Surgery Department, Roger Salengro Hospital, CHU Lille, University of Lille, Lille, France.

Introduction:: The clinical phenotype of pseudohypoparathyroidism (PHP) is caused by Albright's Hereditary Osteodystrophy (AHO). Often, "round face" the only facial clinical sign reported in the literature. The aim of this study was to highlight various cranio-maxillofacial clinical findings associated with AHO. Read More

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November 2018
1 Read

Discussion: Distraction Osteogenesis for Unicoronal Craniosynostosis: Rotational Flap Technique and Case Series.

Plast Reconstr Surg 2018 Dec;142(6):909e-912e

New Haven, Conn. From the Department of Craniofacial Plastic and Reconstructive Surgery, Yale School of Medicine.

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December 2018

Quantitative Analysis of Change in Intracranial Volume After Posterior Cranial Vault Distraction and Frontal Orbital Advancement/Remodeling.

J Craniofac Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Plastic and Reconstructive Surgery, Teikyo University, Tokyo, Japan.

Introduction: Patients with craniosynostosis with shortened occipitofrontal diameter are mainly treated with posterior cranial vault distraction osteogenesis (PVDO) in our institution. If further intracranial volume (ICV) expansion is needed, additional treatment with frontal orbital advancement (FOA) is done. On the contrary, frontal orbital remodeling (FOR) is done for better aesthetic results. Read More

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November 2018
0.676 Impact Factor

Cruciate bibrachial diplegia due to an acutely trapped fourth ventricle.

J R Coll Physicians Edinb 2018 Dec;48(4):328-331

Department of Neurology, Aster Medcity, Kothad, Kochi, India.

A 20-year-old female presented to us with bibrachial diplegia and dysarthria. She had an earlier history of craniosynostosis, multiple cranial surgeries and recent meningitis followed by ventriculoperitoneal shunting. Her symptoms started with a cruciate paralysis followed by rapid descending quadriparesis. Read More

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December 2018

Gα signaling controls intramembranous ossification during cranial bone development by regulating both Hedgehog and Wnt/β-catenin signaling.

Bone Res 2018 20;6:33. Epub 2018 Nov 20.

1Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA USA.

How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. Read More

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November 2018
2 Reads

Non-Syndromic Craniosynostosis Mimicking Primary Pseudotumor Cerebri Syndrome.

Headache 2018 Nov 25. Epub 2018 Nov 25.

Department of Pediatric Neurology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

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November 2018
1 Read

Phenotypic spectrum associated with SPECC1L pathogenic variants: new families and critical review of the nosology of Teebi, Opitz GBBB, and Baraitser-Winter syndromes.

Eur J Med Genet 2018 Nov 22. Epub 2018 Nov 22.

Department of Genetics, APHP-Robert DEBRE University Hospital, Sorbonne Paris-Cité University, and INSERM UMR 1141, Paris, France. Electronic address:

The SPECC1L protein plays a role in adherens junctions involved in cell adhesion, actin cytoskeleton organization, microtubule stabilization, spindle organization and cytokinesis. It modulates PI3K-AKT signaling and controls cranial neural crest cell delamination during facial morphogenesis. SPECC1L causative variants were first identified in individuals with oblique facial clefts. Read More

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November 2018
5 Reads

Polycystins in disease mechanobiology.

J Cell Biochem 2018 Nov 21. Epub 2018 Nov 21.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Distorted mechanotransduction represents the molecular hallmark of disease mechanobiology and is displayed with common features during the development of various pathophysiologies. Polycystins constitute a family of mechanosensitive proteins that facilitate pathogenic signal transduction mechanisms. The main representatives of the family are polycystin-1 (PC1) and polycystin-2 (PC2), which function as a mechano-induced membrane receptor and a calcium-permeable ion channel, respectively. Read More

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November 2018
3 Reads

Airway anomalies in patients with craniosynostosis.

Laryngoscope 2018 Nov 19. Epub 2018 Nov 19.

Department of Otolaryngology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.

Objectives: 1) Characterize the spectrum of airway anomalies in patients with craniosynostosis, and 2) identify clinical characteristics of these patients that may be associated with the development of airway anomalies.

Methods: This study is a retrospective case series assessing the type and frequency of airway anomalies in all patients with craniosynostosis seen at a tertiary-care children's hospital between 2000 and 2016. Cohort analyses were then performed to identify differences in airway anomalies dependent on syndromic associations, multisutural fusion, and location of suture fusion. Read More

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November 2018
3 Reads

Ablepharon and craniosynostosis in a patient with a localized TWIST1 basic domain substitution.

Am J Med Genet A 2018 Nov 18. Epub 2018 Nov 18.

Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.

The TWIST family is a group of highly conserved basic helix-loop-helix transcription factors. In humans, TWIST1 haploinsufficiency causes Saethre-Chotzen syndrome, which is characterized by craniosynostosis. Heterozygous localized TWIST1 and TWIST2 basic domain substitutions exert antimorphic effects to cause Sweeney-Cox syndrome, Barber-Say syndrome, and ablepharon-macrostomia syndrome, respectively. Read More

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November 2018
3 Reads

Ulnar Artery Thrombosis Following Tranexamic Acid Administration for Craniosynostosis Repair.

J Craniofac Surg 2018 Nov 15. Epub 2018 Nov 15.

Department of Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.

Pediatric craniosynostosis repair with cranial vault reconstructive surgery can be associated with significant blood loss. Tranexamic acid (TXA), an antifibrinolytic agent, has been shown to decrease blood loss and transfusion volume in craniofacial surgery. Nonetheless data regarding the safety of TXA remains limited. Read More

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November 2018

Development of Multidirectional Cranial Distraction Osteogenesis for the Treatment of Craniosynostosis.

J Craniofac Surg 2018 Nov 15. Epub 2018 Nov 15.

Department of Plastic Surgery, Jichi Medical University, Shimotsuke.

Background: Previously, the authors developed a new method of distraction osteogenesis for the treatment of craniosynostosis, multidirectional cranial distraction osteogenesis (MCDO). The purpose of this study is to review the authors' experience of MCDO for remodeling of the anterior cranium in the patients of craniosynostosis.

Methods: Forty-five patients with craniosynostosis underwent MCDO for anterior cranial remodeling from 2003 to 2017. Read More

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November 2018
4 Reads

Introduction to the Craniofacial Collaboration UK: A Developmental Screening Protocol at the United Kingdom's Four Highly Specialized Craniofacial Centers.

J Craniofac Surg 2018 Nov 15. Epub 2018 Nov 15.

Oxford Craniofacial Unit, Oxford Children's Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford.

The clinical psychologists at the 4 highly specialized craniofacial centers in the United Kingdom have developed a systematic, developmental screening protocol, called the Craniofacial Collaboration UK (CC-UK). Previous systematic reviews of the literature into the developmental sequelae of single-suture craniosynostosis have identified a number of methodological flaws which the CC-UK seeks to avoid. This study presents an introduction to the rationale for its development, as well as the methodology of the CC-UK. Read More

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November 2018

Perinasal Osteotomy With Distraction Osteogenesis for a Mild Syndromic Craniosynostosis.

J Craniofac Surg 2018 Nov 9. Epub 2018 Nov 9.

Department of Plastic and Reconstructive Surgery, Yokohama City University Hospital, Yokohama, Japan.

Le Fort II and III procedures have generally been performed for syndromic craniosynostosis with midfacial hypoplasia and skeletal class III malocclusion. However, some patients have midfacial hypoplasia without malocclusion. Perinasal osteotomy was performed with distraction osteogenesis to move the midface forward in 2 patients (a 17-year old female patient with Crouzon-like disease and a 15-year-old female patient with Antely-Bixler syndrome) with mild midface hypoplasia without malocclusion. Read More

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November 2018
3 Reads

Posterior Distraction First or Fronto-Orbital Advancement First for Severe Syndromic Craniosynostosis.

J Craniofac Surg 2018 Nov 9. Epub 2018 Nov 9.

Department of Plastic and Reconstructive Surgery.

Purpose: Posterior calvarial vault expansion using distraction osteogenesis is performed for syndromic craniosynostosis as the first choice. This procedure allows far greater intracranial volume than fronto-orbital advancement (FOA). This study aimed to determine the most suitable timing of posterior distraction or FOA to sufficiently increase the intracranial volume and remodel the skull shape. Read More

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November 2018

Large mediastinal mass in a 15-year-old boy.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Paediatric Infectious Disease, Aga Khan University Hospital, Karachi, Pakistan.

Hyperimmunoglobulin E syndrome is a rare multisystem inherited disorder characterised by high serum IgE levels, skin disorder causing eczema, dermatitis, recurrent staphylococcal infections and pulmonary infections and various skeletal and connective tissue abnormalities. Common presentation is with recurrent skin and sinopulmonary infections. Several features unrelated to immune system such as characteristic facial features, hyperextensibility of joints, multiple bone fractures and craniosynostosis have been described in the literature. Read More

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November 2018
5 Reads

Copper-Beaten Skull Appearance as a Response of Chronically Increased Intracranial Pressure.

Am J Forensic Med Pathol 2018 Nov 7. Epub 2018 Nov 7.

From the Institute of Forensic Medicine "Milovan Milovanović," University of Belgrade, School of Medicine, Belgrade, Serbia.

We present a case of 19-year-old female patient, who was injured in childhood and subsequently developed hydrocephalus, chronic elevation of intracranial pressure (ICP), and a copper-beaten skull appearance. Chronic hydrocephalus leads to an increase in intraventricular pressure, causing ventricular expansion and dislocation of adjacent cerebral structures. According to literature data, it has been hypothesized that chronically elevated ICP in persons with craniosynostosis, and other developmental structural abnormalities of the skull, may induce bone remodeling. Read More

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November 2018
1 Read

Identification and Management of Cranial Anomalies in Perinatology.

Clin Perinatol 2018 Dec 18;45(4):699-715. Epub 2018 Sep 18.

Department of Plastic Surgery, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA; Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address:

Neonatal skull and head shape anomalies are rare. The most common cranial malformations encountered include craniosynostosis, deformational plagiocephaly, cutis aplasia, and encephalocele. Improved prenatal imaging can diagnose morphologic changes as early as the second trimester. Read More

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December 2018
6 Reads

Tranexamic Acid Decreases Blood Transfusion Burden in Open Craniosynostosis Surgery Without Operative Compromise.

J Craniofac Surg 2018 Nov 2. Epub 2018 Nov 2.

Department of Neurologic Surgery.

In the surgical management of craniosynostosis, there is a high red blood cell (RBC) transfusion burden due to the small blood volume of the patients combined with significant blood loss that can occur with open surgery (OS). Tranexamic acid (TXA) is an antifibrinolytic which has been shown to decrease such a burden in particular surgeries. The aim of this study was to compare the operative outcomes of craniosynostosis OS which did and did not utilize TXA. Read More

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November 2018
1 Read

Multisuture Craniosynostosis and Papilledema in Pycnodysostosis: A Paradox?

J Craniofac Surg 2018 Nov 2. Epub 2018 Nov 2.

Oxford Craniofacial Unit.

Pycnodysostosis (PYCD) is a rare autosomal-recessive skeletal disorder that typically presents with osteosclerosis of the majority of the postcranial skeleton and osteolysis of the calvarium, manifesting as persistent open cranial fontanelles and widely spaced cranial sutures. Craniosynsostosis in PYCD is a somewhat paradoxical feature, and has only been rarely reported. The authors present a unique case of a 6-year-old girl with PYCD, multisuture craniosynostosis involving the coronal and sagittal sutures, severe obstructive sleep apnoea, and raised intracranial pressure presenting as papilledema. Read More

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November 2018
4 Reads

PLGA-based control release of Noggin blocks the premature fusion of cranial sutures caused by retinoic acid.

Appl Microbiol Biotechnol 2018 Nov 3. Epub 2018 Nov 3.

Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, 56 Lingyuanxi Road, Guangzhou, China.

Craniosynostosis (CS), the premature and pathological fusion of cranial sutures, is a relatively common developmental disorder. Elucidation of the pathways involved and thus therapeutically targeting it would be promising for the prevention of CS. In the present study, we examined the role of BMP pathway in the all-trans retinoic acid (atRA)-induced CS model and tried to target the pathway in vivo via PLGA-based control release. Read More

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November 2018
4 Reads

Deviating dental arch morphology in mild coronal craniosynostosis syndromes.

Clin Oral Investig 2018 Nov 3. Epub 2018 Nov 3.

Department of Oral Maxillofacial Surgery, Special Dental Care and Orthodontics, Dutch Craniofacial Center, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, the Netherlands.

Objectives: To determine whether the intramaxillary relationship of patients with Muenke syndrome and Saethre-Chotzen syndrome or TCF12-related craniosynostosis are systematically different than those of a control group.

Material And Methods: Forty-eight patients (34 patients with Muenke syndrome, 8 patients with Saethre-Chotzen syndrome, and 6 patients with TCF12-related craniosynostosis) born between 1982 and 2010 (age range 4.84 to 16. Read More

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November 2018
1 Read

Mutated zinc finger protein of the cerebellum 1 leads to microcephaly, cortical malformation, callosal agenesis, cerebellar dysplasia, tethered cord and scoliosis.

Eur J Med Genet 2018 Dec 31;61(12):783-789. Epub 2018 Oct 31.

Department Clinical Genetics, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, the Netherlands. Electronic address:

Heterozygous gain of function mutations in the ZIC1 gene have been described with syndromic craniosynostosis, variable cerebral or cerebellar abnormalities and mild to moderate developmental delay. Deletion of chromosome 3q25.1 including both adjacent ZIC1 and ZIC4 genes have been described as a cause of variable cerebellar abnormalities including Dandy-Walker malformation. Read More

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December 2018
4 Reads

Bilambdoid and sagittal synostosis: Report of 39 cases.

Surg Neurol Int 2018 11;9:206. Epub 2018 Oct 11.

Craniofacial Unit, Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Paris, France.

Background: Bilambdoid and sagittal synostosis (BLSS), also called "Mercedes Benz synostosis," is a multisutural craniosynostosis that has been described as a specific entity. However, this synostotic pattern can also be found in syndromic craniostenosis. To better define this entity we reviewed our experience with bilambdoid and sagittal synostosis. Read More

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October 2018
8 Reads

Like a hole in the head: Development, evolutionary implications and diseases of the cranial foramina.

Semin Cell Dev Biol 2018 Oct 30. Epub 2018 Oct 30.

Dept. Comparative Biomedical Sciences, Royal Veterinary College, Royal College St, London, NW1 0TU, United Kingdom.

Cranial foramina are holes in the skull through which nerves and blood vessels pass to reach both deep and superficial tissues. They are often overlooked in the literature; however they are complex structures that form within the developing cranial bones during embryogenesis and then remain open throughout life, despite the bone surrounding them undergoing constant remodelling. They are invaluable in assigning phylogeny in the fossil record and their size has been used, by some, to imply function of the nerve and/or blood vessel that they contained. Read More

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October 2018

Postsurgical Changes in Osseous Dysmorphology of the Midface and Mandible in Unilateral Coronal Craniosynostosis.

J Craniofac Surg 2018 Oct 29. Epub 2018 Oct 29.

Division of Plastic and Reconstructive Surgery, Department of Surgery.

Background: Early management of unilateral coronal synostosis (UCS) aims to treat the cranial abnormality with the hope of improving middle and lower facial morphology. This study analyzed osseous volume and 3-dimensional distances in the midface and mandible of patients with UCS to assess changes in facial symmetry following a cranial vault procedure.

Methods: Patients who underwent fronto-orbital advancement for UCS repair between 1981 and 2012 with follow-up of at least 3 years were included. Read More

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October 2018
1 Read

A Standardized Perioperative Clinical Pathway for Uncomplicated Craniosynostosis Repair Is Associated With Reduced Hospital Resource Utilization.

J Craniofac Surg 2018 Oct 29. Epub 2018 Oct 29.

Division of Plastic and Reconstructive Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.

Background: Hospital resource overutilization can significantly disrupt patient treatment such as cancelling surgical patients due to a lack of intensive care unit (ICU) space. The authors describe a clinical pathway (CP) designed to reduce ICU length of stay (LOS) for nonsyndromic single-suture craniosynostosis (nsSSC) patients undergoing cranial vault reconstruction (CVR) in order to minimize surgical disruptions and improve patient outcomes.

Methods: A multidisciplinary team implemented a perioperative CP including scheduled laboratory testing to decrease ICU LOS. Read More

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October 2018
2 Reads

Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome.

Elife 2018 10 25;7. Epub 2018 Oct 25.

Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States.

Cranial sutures separate the skull bones and house stem cells for bone growth and repair. In Saethre-Chotzen syndrome, mutations in or ablate a specific suture, the coronal. This suture forms at a neural-crest/mesoderm interface in mammals and a mesoderm/mesoderm interface in zebrafish. Read More

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October 2018
9 Reads

Molecular Analyses in a Rabbit Model of Craniosynostosis: Likely Exclusion of Known Candidate Genes as the Loci of Origin.

Cleft Palate Craniofac J 2018 Oct 28:1055665618808623. Epub 2018 Oct 28.

1 Department of Plastic Surgery, University of Pittsburgh/Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Objective:: Craniosynostosis (CS) involves the premature fusion of one or more cranial sutures. We work with a naturally occurring rabbit model of CS with an undefined etiology. Known causes of coronal CS were evaluated to identify potential associations with CS in the rabbit. Read More

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October 2018
5 Reads

[Three-Dimensional Skull Model with Vascular Structures for Occipital Expansion in Patients with Developed Occipital Emissary Veins].

No Shinkei Geka 2018 Oct;46(10):877-882

Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science, University of Toyama.

We report the application of a three-dimensional skull model with vascular structures for occipital expansion in a patient who had developed occipital emissary veins. A 15-year-old boy visited a dentist for orthodontic treatment and was diagnosed with midface hypoplasia. He had undergone a ventriculo-peritoneal shunt at the age of 10 months. Read More

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October 2018
5 Reads

Multicentre approach to epidemiological aspects of craniosynostosis in Germany.

Br J Oral Maxillofac Surg 2018 Nov 22;56(9):881-886. Epub 2018 Oct 22.

Malformation Monitoring Centre Saxony-Anhalt, Medical Faculty Otto-von-Guericke University Magdeburg, Leipziger Str. 44, Haus 39, 39120 Magdeburg, Germany. Electronic address:

We know of no current published data on the prevalence of craniosynostosis in Germany, so our objective in this study was to contribute to the limited knowledge of its epidemiology by assessing time trends, the frequency of prenatal diagnosis, and the timing of diagnosis and treatment. Data were collected in Saxony-Anhalt during the period 2000-17, and we designed a retrospective multicentre cohort study. The prevalence was 4. Read More

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November 2018
5 Reads

Characterization of Perinatal Risk Factors and Complications Associated with Nonsyndromic Craniosynostosis.

J Craniofac Surg 2018 Oct 24. Epub 2018 Oct 24.

Department of Neurosurgery, Duke University Medical Center, Durham, NC.

Background: Certain intrauterine risk factors are known to increase the risk of premature cranial suture fusion and may cause complications during birth. Some of these risk factors may be modifiable. Therefore, the authors sought to characterize the institutional patterns of prenatal risk factors and perinatal complications in nonsyndromic craniosynostosis patients compared to normal births from the surrounding area to identify areas for possible intervention or prevention. Read More

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October 2018
4 Reads

Subjective Assessment of Head and Facial Appearance in Children with Craniosynostoses after Surgical Treatment.

Healthcare (Basel) 2018 Oct 24;6(4). Epub 2018 Oct 24.

Institute of Sociology, University of Opole, Katowicka 89, 45-061 Opole, Poland.

Background: Craniosynostoses are congenital defects in the construction of the skull involving premature fusion of one or more cranial sutures. Premature fusion of sutures causes characteristic skull deformation(s). This affect the structure and thus the appearance of the entire head and face. Read More

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October 2018
4 Reads

High Incidence of Cranial Synostosis and Chiari I Malformation in Children With X-Linked Hypophosphatemic Rickets (XLHR).

J Bone Miner Res 2018 Oct 23. Epub 2018 Oct 23.

Pediatric Neurosurgery, Hôpital Femme Mère Enfant, Hospices Civiles de Lyon and University Claude Bernard Lyon 1, Bron Cedex, France.

X-linked hypophosphatemic rickets (XLHR) represents the most common form of genetic hypophosphatemia and causes rickets and osteomalacia in children because of increased FGF23 secretion and renal phosphate wasting. Even though cranial vault and craniovertebral anomalies of potential neurosurgical interest, namely early closure of the cranial sutures and Chiari type I malformation, have been observed in children with XLHR, their actual incidence and characteristics are not established. The aims of this study were to analyze the incidence of cranial and cervico-occipital junction (COJ) anomalies in children with XLHR and describe its features. Read More

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October 2018
8 Reads

Prevention of recurrence post leptomeningeal cyst repair.

Neurosciences (Riyadh) 2018 Oct;23(4):338-342

Department of Neurosurgery, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail:

Leptomeningeal cysts, which are cystic collections filled with cerebrospinal fluid, are rare complications following pediatric head trauma and surgical correction of craniosynostosis. These cysts develop due to cerebrospinal fluid pulsations and brain growth that cause expansion of the dural tears. Although primary repair of the dural defect is the definitive treatment, the risk of cyst recurrence remains. Read More

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October 2018
3 Reads

Copper Beaten Skull.

J Pediatr 2018 Oct 19. Epub 2018 Oct 19.

Pandit BD Sharma Post Graduate Institute of Medical Sciences Rohtak, Haryana, India.

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October 2018

BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair.

Bone Res 2018 17;6:30. Epub 2018 Oct 17.

1Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA USA.

Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells (MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Read More

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October 2018

Prenatal ultrasonography of craniofacial abnormalities.

Ultrasonography 2018 Jul 3. Epub 2018 Jul 3.

Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital, Hong Kong SAR, China.

Craniofacial abnormalities are common. It is important to examine the fetal face and skull Epub ahead of print during prenatal ultrasound examinations because abnormalities of these structures may indicate the presence of other, more subtle anomalies, syndromes, chromosomal abnormalities, or even rarer conditions, such as infections or metabolic disorders. The prenatal diagnosis of craniofacial abnormalities remains difficult, especially in the first trimester. Read More

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July 2018
3 Reads

"Craniometric Analysis of Endoscopic Suturectomy for Bilateral Coronal Craniosynostosis."

Plast Reconstr Surg 2018 Oct 10. Epub 2018 Oct 10.

Background: Endoscopic suturectomy and helmeting represents a successful first-line surgical treatment for bilateral coronal craniosynostosis. Its effect on cranial morphology has not been previously described.

Methods: Patients were identified who had bilateral coronal craniosynostosis treated with endoscopic suturectomy and postoperative helmeting at Boston Children's Hospital between 2005 and 2013 and who received pre- and post-operative CT scans. Read More

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October 2018
6 Reads
2.990 Impact Factor

Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model.

Mol Ther Nucleic Acids 2018 Dec 22;13:291-302. Epub 2018 Sep 22.

Laboratory for the Rehabilitation of Traumatic Injuries, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. Electronic address:

Apert syndrome (AS), the most severe form of craniosynostosis, is caused by missense mutations including Pro253Arg(P253R) of fibroblast growth factor receptor 2 (FGFR2), which leads to enhanced FGF/FGFR2-signaling activity. Surgical correction of the deformed skull is the typical treatment for AS. Because of constant maldevelopment of sutures, the corrective surgery is often executed several times, resulting in increased patient challenge and complications. Read More

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December 2018
1 Read

A comparison of the effect of propofol and alfaxalone on laryngeal motion in nonbrachycephalic and brachycephalic dogs.

Vet Anaesth Analg 2018 Nov 21;45(6):729-736. Epub 2018 Jul 21.

Department of Veterinary Clinical Sciences, Royal Veterinary College, Hatfield, Hertfordshire, UK.

Objective: To compare the effect of propofol and alfaxalone on laryngeal motion under a light plane of anaesthesia in nonbrachycephalic and brachycephalic dogs anaesthetized for nonemergency procedures.

Study Design: Prospective, randomized clinical trial.

Animals: A total of 48 client-owned dogs (24 nonbrachycephalic and 24 brachycephalic). Read More

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November 2018
5 Reads

Magnetic resonance imaging of the fetal brain at 3 Tesla: Preliminary experience from a single series.

Medicine (Baltimore) 2018 Oct;97(40):e12602

Department of Diagnostic and Therapeutic Neuroradiology, Centre Hospitalier Universitaire (CHU) - Hôpital Pierre Paul Riquet, University of Toulouse, Toulouse, France.

To report our preliminary experience with cerebral fetal magnetic resonance imaging (MRI) with a 3 Tesla (3T) scanner. We assessed feasibility, time of acquisition, and possibility to establish a diagnosis.Fifty-nine pregnant women had fetal MRI performed during the third trimester of pregnancy due to clinical or sonography concern of a central nervous system anomaly. Read More

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October 2018
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