Search Our Scientific Publications & Authors

J Craniofac Surg 2022 Jun 28. Epub 2022 Jun 28.

Department of Otorhinolaryngology-Head and Neck Surgery; and.

Abstract: Craniopharyngioma is rare epithelial tumor that develops along the craniopharyngeal duct, and most of these tumors occur in the sellar and suprasellar regions. Although it rarely occurs in the extracranial region, sphenoid solitary lesions were not reported in previous literature. In this study, we report a case of infrasellar craniopharyngioma within the sphenoid sinus without intracranial lesion. Read More

BMJ Case Rep 2022 06 24;15(6). Epub 2022 Jun 24.

Department of Pediatrics, Division of Child Neurology, Children's Hospital of Orange County and UC Irvine, Orange, California, USA

J Pers Med 2022 Jun 8;12(6). Epub 2022 Jun 8.

Department of Endocrinology, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.

Xanthogranuloma of the sellar region is a rare chronic inflammatory lesion resulting from secondary hemorrhage, inflammation, infarction, and necrosis of an existing Rathke's cleft cyst, craniopharyngioma, or pituitary adenoma. Sellar xanthogranulomas are challenging to differentiate from other cystic lesions preoperatively due to the lack of characteristic imaging features. We performed a literature overview of the clinical and paraclinical features, treatment options, and long-term outcomes of patients with sellar xanthogranuloma, focusing on the preoperative radiological diagnosis. Read More

Radiol Case Rep 2022 Aug 11;17(8):2863-2868. Epub 2022 Jun 11.

Department of Neurological Surgery, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan.

A 34-year-old woman presented with progressive visual impairment for 2 months. Computed tomography and magnetic resonance imaging (MRI) revealed a suprasellar cyst. The patient underwent endoscopic endonasal surgery, which resulted in gross total resection with a diagnosis of craniopharyngioma. Read More

Obesity (Silver Spring) 2022 Jun 16. Epub 2022 Jun 16.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Objective: This study aimed to recapitulate the change trajectory of postoperative weight and investigate the association between postoperative hypothalamic damage and weight gain and hypothalamic obesity (HO) in patients with adult-onset craniopharyngioma.

Methods: The data of 96 patients with surgically treated primary adult-onset craniopharyngioma were retrospectively analyzed. The association between postoperative hypothalamic damage based on magnetic resonance images or endoscopic observation and postoperative weight gain and HO was determined by multivariable logistic regression. Read More

Front Oncol 2022 26;12:865865. Epub 2022 May 26.

Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi'an, China.

Objective: To improve the diagnosis and treatment of intracranial chondromas (ICDs) by discussing the clinical manifestations and imaging characteristics of ICDs, as well as surgical methods and treatment strategies.

Methods: We retrospectively analyzed 17 patients diagnosed with ICDs who underwent microsurgery or endoscopic transsphenoidal surgery at the Tangdu Hospital of Air Force Military Medical University and the Mianyang Central Hospital from January 2010 to November 2021. Clinical manifestations, imaging examinations, surgical treatments, and prognosis of these patients were analyzed. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):542-544

Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

World Neurosurg 2022 May 31. Epub 2022 May 31.

Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: Papillary craniopharyngioma (PCP) was previously thought to occur only in adults. Sporadic pediatric PCP (PPCP) confirmed by detection of BRAF V600E mutation has been reported since 2018, but is often misdiagnosed before being diagnosed definitively. We aimed to evaluate PPCP characteristics and propose diagnostic criteria for prompt diagnosis, seeking to reduce patient morbidity and mortality and reduce costs linked to misdiagnosis. Read More

Intern Med 2022 May 21. Epub 2022 May 21.

Department of Neurology, Juntendo University School of Medicine, Japan.

We experienced a young patient who presented with progressive parkinsonism and cerebellar ataxia. Brain magnetic resonance imaging revealed progressive brain calcification, expanding from the bilateral basal ganglia to the central pons, caused by a delayed reaction to the radiation therapy that she had received to treat craniopharyngioma 14 years earlier. Heterogeneous clinical symptoms due to radiation-induced brain calcification have been described, but parkinsonism has never been reported. Read More

Eur J Endocrinol 2022 Jun 20;187(2):219-230. Epub 2022 Jun 20.

Department of Internal Medicine of Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.

Objectives: To evaluate how telomere length behaves in adamantinomtous craniopharyngioma (aCP) and if it contributes to the pathogenesis of aCPs with and without CTNNB1 mutations.

Design: Retrospective cross-sectional study enrolling 42 aCP patients from 2 tertiary institutions.

Methods: Clinicopathological features were retrieved from the patient's charts. Read More

Can J Neurol Sci 2022 May 18:1-7. Epub 2022 May 18.

Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec, Canada.

Background: The optimal treatment of adult craniopharyngioma (CP) remains controversial. Although benign, these tumors tend to recur locally. The choice between gross total resection (GTR) versus subtotal resection (STR) with adjuvant or delayed radiotherapy (RT) is debated. Read More

World Neurosurg 2022 May 12;164:177. Epub 2022 May 12.

Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Excision through craniotomy is used for pediatric craniopharyngioma removal. However, residual tumors can sometimes be found in the blind spot of the microscopic field, such as the third ventricle wall, back of the optic chiasm, and brainstem surface, during surgery. Video 1 demonstrates the surgery using a flexible endoscope for the removal of residual tumor located within the blind spot of the first resection. Read More

Front Pediatr 2022 26;10:870951. Epub 2022 Apr 26.

Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: To analyze the clinical character of giant pediatric supratentorial tumor (GPST) and explore prognostic factors.

Materials And Methods: We analyzed the clinical data comprising of 35 cases of GPST from a single center between January 2015 and December 2020. The tumor volume was measured by 3D slicer software based on preoperative magnetic resonance imaging (MRI). Read More

Neuro Oncol 2022 May 12. Epub 2022 May 12.

Departments of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Background: Our aim was to estimate long-term disease control and complications after conformal radiation therapy (CRT) in children and adolescents with craniopharyngioma.

Materials And Methods: Pediatric patients with craniopharyngioma (n=101) were enrolled on or treated according to a phase II single institutional protocol from 1998. Surgery was individualized, and CRT (54Gy) was administered using a 1. Read More

J Clin Neurosci 2022 Jun 28;100:204-211. Epub 2022 Apr 28.

Department of Pathology, Tangdu Hospital, Air Force Medical University, Xi'an, PR China. Electronic address:

Collision tumors are extremely rare in the sellar region, and their features have not been fully characterized. Here, we report our single-center experience in the diagnosis and management of these tumors, focusing primarily on their clinicopathological features. We first performed a retrospective study of pathological reports from patients who had undergone surgery for pituitary adenoma (PA) or craniopharyngioma (CP) at our hospital. Read More

J Neuropathol Exp Neurol 2022 Apr 26. Epub 2022 Apr 26.

Statistics Department, Computing Center, C.S.I.C. Madrid, Spain.

This study investigates the presence of a hollow recess at the midline undersurface of tumors primarily localized within the third ventricle (3V). This structure was originally identified by magnetic resonance imaging (MRI) of 6 3V craniopharyngiomas (CPs) from our series and was then methodically scrutinized in autopsy studies (n = 1091) and MRI scans (n = 5558) of CPs and in 1251 3V tumors reported in the medical literature from 1839 to 2021. A recess at the tumor base was identified in 110 CPs, 95 with a verified papillary histology (papillary craniopharyngioma [PCP]) and 15 with typical gross appearance of PCP. Read More

Pediatr Neurosurg 2022 5;57(3):202-206. Epub 2022 Apr 5.

Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.

Introduction: Colloid cysts are relatively uncommon lesions in the pediatric population. The xanthogranulomatous (XG) variant is very rare with less than 30 reported cases.

Case Report: In this report, the patient was a 13-year-old boy who presented with transient episodes of headache with blurring of vision. Read More

World Neurosurg 2022 Jul 30;163:e230-e237. Epub 2022 Mar 30.

Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Objective: Internal carotid artery (ICA) injury during transsphenoidal surgery is a rare but serious complication. We analyzed a series of ICA injuries that occurred during a transsphenoidal approach to suggest an optimal management strategy.

Methods: Between January 2015 and May 2020, we enrolled 10 cases of ICA injury at our institution. Read More

Sci Rep 2022 03 30;12(1):5355. Epub 2022 Mar 30.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

We assessed the retinal microvascular alterations detected by optical coherence tomography angiography (OCT-A) in pediatric and juvenile craniopharyngioma (CP) patients with chiasmal compression. We included 15 eyes of 15 pediatric or juvenile CP patients and 18 eyes of 18 healthy subjects. The evaluation of vessel density from the superficial retinal capillary plexus (SRCP), the deep retinal capillary plexus, and the radial peripapillary capillary (RPC) segments was obtained by OCT-A. Read More

Curr Oncol 2022 03 4;29(3):1645-1671. Epub 2022 Mar 4.

Department of Neurosurgery, College of Medicine, University of Florida, 653 8th St W., Jacksonville, FL 32209, USA.

Craniopharyngiomas (CPs) are slow growing, histologically benign intracranial tumors located in the sellar-suprasellar region. Although known to have low mortality, their location and relationship to the adjacent neural structures results in patients having significant neurologic, endocrine, and visual comorbidities. The invasive nature of this tumor makes complete resection a challenge and contributes to its recurrence. Read More

World Neurosurg 2022 Jun 20;162:e587-e596. Epub 2022 Mar 20.

Department of Neurological Sciences, Christian Medical College, Vellore, India.

Background: There is limited literature on outcomes after surgical treatment of giant craniopharyngiomas in adult and pediatric patients.

Methods: A retrospective review of 159 patients undergoing surgery for craniopharyngiomas at a single institution was performed. Patients with giant craniopharyngiomas (maximum dimension ≥4. Read More

Cureus 2022 Mar 13;14(3):e23128. Epub 2022 Mar 13.

Neurosurgery, Great Lakes Neurosurgical Associates PC, Grand Rapids, USA.

An aneurysmal bone cyst is a locally destructive benign lesion that predominately affects the long bones. Sphenoid body involvement is rare. To date, only 19 primary aneurysmal bone cysts of the sphenoid body have been reported. Read More

Neurol India 2022 Jan-Feb;70(1):57-62

Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Background: Complex craniopharyngiomas pose a significant surgical challenge owing to its proximity to critical structures and its intrinsic nature to resist radical excision.

Objective: To show that endoscopic endonasal approach (EEA) is potentially a better alternative to transcranial approach in tumors that have been operated multiple times by transcranial route for achieving radical excision with minimal morbidity.

Materials And Methods: A 32-year-old male previously operated twice through interhemispheric approach for craniopharyngioma presented with blurring of vision accompanied by headache and intermittent diplopia. Read More

Pediatr Neurosurg 2022 9;57(3):191-195. Epub 2022 Mar 9.

Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.

Introduction: Abscess within a craniopharyngioma (CPG) is extremely rare and only 8 such cases have been reported in literature. Most patients present with hypopituitarism and visual disturbances. We report the first ever case of a CPG with abscess in a pediatric patient. Read More

Otolaryngol Clin North Am 2022 Apr 4;55(2):233-246. Epub 2022 Mar 4.

Department of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, CA-51, Cleveland, OH 44195, USA; Section of Skull Base Surgery, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, CA-51, Cleveland, OH 44195, USA; Section of Rhinology, Sinus, & Skull Base Surgery, Head and Neck Institute, Cleveland Clinic, 9500 Euclid Avenue, CA-51, Cleveland, OH 44195, USA. Electronic address:

The pituitary gland plays a vital role in hormonal regulation. Pituitary lesions include tumors, cysts, and inflammatory processes that require multidisciplinary care from endocrinologists, neuro-ophthalmologists, neurosurgeons, and otolaryngologists. Treatment is typically aimed at controlling hormonal hypersecretion, decompressing the optic apparatus, and reducing tumor volume, and surgery is a common first-line approach. Read More

Neurocirugia (Astur : Engl Ed) 2022 Mar-Apr;33(2):99-104

Department of Neurosurgery, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Pituitary abscesses are very uncommon. They are divided into primary, arising within a healthy gland, and secondary, observed with an underlying pre-existing lesion. Here we present the eighth case reported of a secondary abscess within a craniopharyngioma. Read More

Cureus 2022 Jan 25;14(1):e21588. Epub 2022 Jan 25.

Neurosurgery, Hospital Universitario Antonio Pedro, Rio de Janeiro, BRA.

Craniopharyngiomas are supra/parasellar lesions that often present with general, unspecific symptoms. Similarly, internal carotid artery (ICA) bifurcation giant aneurysms may also produce calcified, heterogeneous, parasellar expansive lesions, posing a relevant differential diagnosis due to their inherently different surgical strategies and risks. We report the case of a 54-year-old female presenting with progressive disorientation and apathetic behavior. Read More

J Psychiatr Res 2022 04 2;148:240-249. Epub 2022 Feb 2.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address:

The presentation of psychiatric symptoms in pediatric low-grade brain tumors is challenging because this can delay proper diagnosis and treatment. We performed a systematic review of psychiatric presenting symptoms of low-grade brain tumors in pediatric patients. We searched the PubMed and Web of Science databases of studies published in English from 1977 until 2019 reporting patients aged ≤21 years at the time of tumor diagnosis who exhibited psychiatric/behavioral symptoms before diagnosis of low-grade glioma (LGG), pilocytic astrocytoma (PA), or craniopharyngioma (CP). Read More

Oper Neurosurg (Hagerstown) 2022 04;22(4):192-200

Department of Neurosurgery, University Medicine Greifswald, Greifswald, Germany.

Background: A paradigm shift toward less radicality in the treatment of craniopharyngioma (CP) has increasingly gained recognition. In selected patients, a less invasive approach aiming at cyst decompression may be suitable.

Objective: To present our experience with the endoscopic transcortical-transventricular approach (ETTA) for the treatment of CP located in the third ventricle, describe our surgical technique, and explore the results reported in the literature. Read More

Comput Methods Programs Biomed 2022 Apr 21;216:106651. Epub 2022 Jan 21.

CBSR&NLPR, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China; School of Artificial Intelligence, University of the Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Background And Objective: Craniopharyngioma is a kind of benign brain tumor in histography. However, it might be clinically aggressive and have severe manifestations, such as increased intracranial pressure, hypothalamic-pituitary dysfunction, and visual impairment. It is considered challenging for radiologists to predict the invasiveness of craniopharyngioma through MRI images. Read More