5,655 results match your criteria Craniopharyngioma

Effects of stereotactic radiosurgery versus conventional radiotherapy on body mass index in patients with craniopharyngioma.

J Neurosurg Pediatr 2021 May 14:1-7. Epub 2021 May 14.

1Department of Neurosurgery, Neurological Institute.

Objective: Hypothalamic obesity is common among patients with craniopharyngioma. This study examined whether precise stereotactic radiosurgery reduces the risk of hypothalamic obesity in cases of craniopharyngioma with expected long-term survival.

Methods: This cohort study included 40 patients who had undergone Gamma Knife radiosurgery (GKRS; n = 22) or fractionated radiotherapy (FRT; n = 18) for residual or recurrent craniopharyngioma. Read More

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Intraoperative Ultrasound-Assisted Extent of Resection Assessment in Pediatric Neurosurgical Oncology.

Front Oncol 2021 21;11:660805. Epub 2021 Apr 21.

Neurosurgery Unit, Department of Neurological and Psychiatric Sciences, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Central nervous system tumors represent the most frequent solid malignancy in the pediatric population. Maximal safe surgical resection is a mainstay of treatment, with significant prognostic impact for the majority of histotypes. Intraoperative ultrasound (ioUS) is a widely available tool in neurosurgery to assist in intracerebral disease resection. Read More

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Craniopharyngiomas, Including Recurrent Cases, Lack TERT Promoter Hotspot Mutations.

Neurol Med Chir (Tokyo) 2021 May 8. Epub 2021 May 8.

Divisions of Neuro-Oncology and Hematology/Oncology, Departments of Medicine and Neurology, Massachusetts General Hospital Cancer Center, Harvard Medical School.

Adamantinomatous craniopharyngiomas (ACP) are characterized by alterations in the CTNNB1 gene while almost all papillary craniopharyngiomas (PCP) harbor a canonical V600E mutation in the BRAF gene. Although other recurrent driver genes have not been described to date in craniopharyngiomas, the heterogeneous clinical course of these tumors might be associated with the acquisition of further genomic alterations. It is well known that telomerase reverse transcriptase (TERT) promoter (TERTp) alterations, including mutations or methylation, upregulate the expression of TERT and increase telomerase activity, promoting tumorigenesis. Read More

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Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma.

Front Horm Res 2021 May 7;54:1-11. Epub 2021 May 7.

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

Although childhood-onset craniopharyngioma is a low-grade intracranial tumor with excellent prognosis in terms of overall survival, survivors may suffer from devastating consequences caused by hypothalamic damage. Disease- or treatment-related hypothalamic damage leads to disturbed hunger-satiety and thirst feelings, decreased energy expenditure, behavioral problems, disturbances of circadian rhythm, temperature dysregulation, and pituitary dysfunction. These children are at great risk for developing the metabolic syndrome and comorbidities leading to premature mortality. Read More

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The predictive value of intraoperative visual evoked potential for visual outcome after extended endoscopic endonasal surgery for adult craniopharyngioma.

J Neurosurg 2021 May 7:1-11. Epub 2021 May 7.

1Department of Neurosurgery, Beijing Tiantan Hospital, and.

Objective: Due to the proximity of craniopharyngioma to the optic apparatus, one of the most common complications after surgery is visual deterioration. Intraoperative visual evoked potential (VEP), as a means of real-time visual function monitoring, has been integrated into transsphenoidal surgery for pituitary adenoma to predict postoperative visual outcome. Compared with pituitary tumor, craniopharyngioma often adheres to optic nerves, with increased risk of postoperative visual impairment. Read More

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Petrosal Approach for Giant Retrochiasmatic Craniopharyngioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 May;20(6):E420-E421

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Microsurgical resection of craniopharyngiomas poses significant challenges, which are amplified with tumors in the retrochiasmatic location and larger size. Traditional pterional trans-sylvian, subfrontal translamia terminalis, or interhemispheric approaches provide narrow surgical corridors with obstructed visualization of the tumor by the prefixed chiasm and slit optic carotid window.1-5 The superior extension of the tumor compressing the hypothalamus and third ventricle are likewise inaccessible. Read More

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Clinicopathological Features of Craniopharyngioma: A 15-Year Study From a Tertiary Care Center in Pakistan.

Cureus 2021 Mar 28;13(3):e14153. Epub 2021 Mar 28.

Pathology, Liaquat National Hospital and Medical College, Karachi, PAK.

Introduction Craniopharyngiomas (CPs) are benign neoplasms and most common suprasellar tumors. They are more frequent in children, contributing to a significant number of intracranial tumors in the pediatric population and are thought to be arising either from the epithelial remnant cells of the craniopharyngeal duct or from the adenohypophysis epithelium. Two subtypes of CPs exist, namely, adamantinomatous craniopharyngioma (ACP) and papillary craniopharyngioma (PCP). Read More

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Aggressive Childhood-onset Papillary Craniopharyngioma Managed With Vemurafenib, a BRAF Inhibitor.

J Endocr Soc 2021 May 16;5(5):bvab043. Epub 2021 Mar 16.

Division of Neurosurgery, Department of Surgery, University of Alberta, Walter Mackenzie Health Sciences Centre, Edmonton, AB T6G 2B7, Canada.

The papillary subtype of craniopharyngioma (CP) rarely occurs in children and commonly presents as a suprasellar lesion. Patients with papillary CPs frequently harbor the -V600E mutation, and treatment with a BRAF inhibitor results in tumor shrinkage in several patients. Herein, we report a patient with childhood-onset papillary CP treated with vemurafenib for 40 months after multiple surgeries. Read More

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Management Options for Suprasellar Cystic Craniopharyngioma: Endoscopic Transventricular Approach and Microsurgical Approach.

J Neurosci Rural Pract 2021 Apr 1;12(2):343-349. Epub 2021 Apr 1.

Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

 The treatment of cystic craniopharyngioma in children is varied. The treatment ranges from radical excision to direct radiotherapy. As the morbidity of excision is high, more conservative approaches are used. Read More

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Editorial: Characteristics and overall survival in pediatric versus adult craniopharyngioma: a population-based study.

Todd C Hankinson

Childs Nerv Syst 2021 Apr 27. Epub 2021 Apr 27.

Department of Pediatric Neurosurgery, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 E 16th Ave, Aurora, CO, 80045, USA.

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Clinical characteristics and genetic analyses in a Chinese family affected by primary aldosteronism: a case report.

Ann Palliat Med 2021 Apr 16. Epub 2021 Apr 16.

Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Branch of National Clinical Research Center for Metabolic Disease, Wuhan, China.

The clinical and aetiological characteristics of family-clustered primary aldosteronism (PA) are not fully understood and need further exploration. Our study reported a PA case with a family history accompanied by unusual concomitant disease and explored the genetic background of the affected family members, thus providing more evidence of the manifestation and pathogenesis of family-clustered PA. We studied a family with PA in which the proband and her maternal aunt were diagnosed with aldosteroneproducing adenoma (APA) and primary adrenal hyperplasia (PAH), respectively. Read More

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Appetite and weight inducing and inhibiting neuroendocrine factors in Prader-Willi syndrome, Bardet-Biedl syndrome and craniopharyngioma versus anorexia nervosa.

Endocr Connect 2021 Apr 1. Epub 2021 Apr 1.

A Hokken-Koelega, Erasmus MC Sophia Children Hospital, Rotterdam, Netherlands.

Obesity is reaching endemic state and has a major impact on health and economy. In most cases obesity is caused by life style factors. However, the risk of becoming obese differs highly between people. Read More

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Imaging of the Primary Visual Pathway based on Visual Deficits.

J Clin Imaging Sci 2021 7;11:19. Epub 2021 Apr 7.

Department of Radiology, Mayo Clinic, Jacksonville, Florida, United States.

Vision loss can occur due to a variety of etiologies along the primary visual pathway. Understanding the anatomic organization of the visual pathway, which spans the globe to the occipital cortex, can help tailor neuroimaging to identify the cause of visual dysfunction. In this review, relevant anatomy and optimization of computed tomography and magnetic resonance imaging techniques will be described. Read More

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Aetiologies and clinical patterns of hypopituitarism in Sudanese children.

Sudan J Paediatr 2021 ;21(1):53-60

Department of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

There is paucity of reported information regarding aetiology and clinical profile of hypopituitarism from resource-limited countries particularly in populations with high rates of consanguineous marriages. Here, we are reporting the first data on this aspect from Sudan. This is a descriptive, retrospective, hospital-based study, carried out in the two main paediatric endocrinology centres in Sudan (Gafaar Ibn Auf Paediatric Tertiary Hospital and Soba University Hospital, Khartoum) from January 2006 up to December 2014. Read More

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January 2021

[The 2017 WHO classification of pituitary tumors].

Wolfgang Saeger

Pathologe 2021 May 20;42(3):333-351. Epub 2021 Apr 20.

Institute für Pathologie und Neuropathologie, Universität Hamburg, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland.

The 2017 WHO classification of pituitary tumors is still based on structural analyses and expression of various pituitary hormones. Three innovations have to be considered: (1) The expression of pituitary transcription factors Pit‑1, T‑Pit and SF‑1. (2) The term "atypical adenoma" was replaced by "aggressive adenoma". Read More

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Hypothalamic Rax tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice.

Nat Commun 2021 04 16;12(1):2288. Epub 2021 Apr 16.

State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

Hypothalamic tanycytes in median eminence (ME) are emerging as a crucial cell population that regulates endocrine output, energy balance and the diffusion of blood-born molecules. Tanycytes have recently been considered as potential somatic stem cells in the adult mammalian brain, but their regenerative and tumorigenic capacities are largely unknown. Here we found that Rax+ tanycytes in ME of mice are largely quiescent but quickly enter the cell cycle upon neural injury for self-renewal and regeneration. Read More

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Incidence and possible predictors of sodium disturbance after craniopharyngioma resection based on QST classification.

World Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

Affiliations: Department of Neurosurgery, Nanfang Hospital of Southern Medical University, Guangzhou, China.

Objective: Serum sodium abnormalities are one of the most common manifestations following radical CP excision. The aim of this study was to report the incidence and possible predictors of serum sodium disturbance and explore features of sodium destabilization manifestation among QST classification results following craniopharyngioma resection.

Methods: A retrospective analysis of clinical, biochemical, radiological and operative data for 134 successive patients who underwent primary craniopharyngioma removal between September 2016 and March 2018 was performed. Read More

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An endoscopic endonasal approach to craniopharyngioma via the infrachiasmatic corridor: a single center experience of 84 patients.

Acta Neurochir (Wien) 2021 Apr 8. Epub 2021 Apr 8.

Neurosurgery Department, Pituitary Research Center, Kocaeli University, Kocaeli, Turkey.

Object: The infrachiasmatic corridor is the most important surgical access route for craniopharyngiomas and was identified and used in clinical series. The aims of this study were to describe the characteristics that assist dissection and resection rates in endoscopic surgery of solid, cystic, and recurrent cases and their importance in the infrachiasmatic corridor in endoscopic surgery.

Methods: One hundred operations on 84 patients with pathologically identified craniopharyngioma were included in the study. Read More

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Mechanical thrombectomy performed in thrombosed fusiform aneurysm after surgery for craniopharyngioma in adult: Case report.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Mar 31. Epub 2021 Mar 31.

Department of Radiology, Faculty of Medicine in Hradec Kralove, Charles University and University Hospital Hradec Kralove, Czech Republic.

Introduction: Fusiform dilatation of the internal carotid artery (ICA) is reported as a possible complication of craniopharyngioma resection in childhood. Here, the authors describe such a complication in an adult patient who presented with acute symptomatic thrombosis 7 months after surgery.

Materials And Methods: A 45-year-old woman presented with left hemispheric stroke due to a thrombotic supraclinoid occlusion of the terminal ICA (so called "T" occlusion). Read More

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Complete versus Subtotal Resection of Paediatric Craniopharyngioma.

J Pak Med Assoc 2021 02;71(2(A)):564-566

Department of Neurosurgery,The Aga Khan University Hospital, Karachi.

Optimal management of craniopharyngioma is challenging and requires multidisciplinary efforts for a successful outcome. The debate over radical versus a conservative resection followed by radiotherapy, continues. Current literature reports no difference in disease freedom and overall survival between the two surgical viewpoints, and favours conservative resection and radiotherapy, leading to lower morbidity and superior functional outcomes. Read More

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February 2021

Predicting the location of the preoptic and anterior hypothalamic region by visualizing the thermoregulatory center on fMRI in craniopharyngioma using cold and warm stimuli.

Aging (Albany NY) 2021 Mar 26;13(7):10087-10098. Epub 2021 Mar 26.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Hypothalamic nuclei in the preoptic and anterior hypothalamic region (POAH) are critically involved in thermoregulation and neuroendocrine regulation and can be displaced by craniopharyngiomas (CPs). We aimed to locate the POAH by visualizing hypothalamic thermoregulation through task-related functional magnetic resonance imaging (fMRI) to guide hypothalamus protection intraoperatively. Nine adult healthy volunteers (HVs) and thirty-two adult primary CP patients underwent task-related fMRI for POAH localization by warm (60° C) and cold (0° C) cutaneous thermoreceptor stimulation. Read More

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Typical Pediatric Brain Tumors Occurring in Adults-Differences in Management and Outcome.

Biomedicines 2021 Mar 30;9(4). Epub 2021 Mar 30.

Department of Neurosurgery, University Hospital of Basel, 4031 Basel, Switzerland.

Adult brain tumors mostly distinguish themselves from their pediatric counterparts. However, some typical pediatric brain tumors also occur in adults. The aim of this review is to describe the differences between classification, treatment, and outcome of medulloblastoma, pilocytic astrocytoma, and craniopharyngioma in adults and children. Read More

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Postoperative and Long-Term Endocrinologic Complications of Craniopharyngioma.

Abdullah Bereket

Horm Res Paediatr 2020 1;93(9-10):497-509. Epub 2021 Apr 1.

Division of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Turkey.

Background: Craniopharyngioma (CP), despite being a malformational tumor of low histological grade, causes considerable morbidity and mortality mostly due to hypothalamo-pituitary dysfunction that is created by tumor itself or its treatment.

Summary: Fluid-electrolyte disturbances which range from dehydration to fluid overload and from hypernatremia to hyponatremia are frequently encountered during the acute postoperative period and should be carefully managed to avoid permanent neurological sequelae. Hypopituitarism, increased cardiovascular risk, hypothalamic damage, hypothalamic obesity, visual and neurological deficits, and impaired bone health and cognitive function are the morbidities affecting the well-being of these patients in the long term. Read More

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Safety and Efficacy of Endoscopic Dorsum Sellar Resection for Access to Retroinfundibular or Upper Clival Tumors (Korean Society of Endoscopic Neurosurgery-008).

World Neurosurg 2021 Mar 23. Epub 2021 Mar 23.

Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea; Pituitary Center, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Objective: The retroinfundibular and upper clival regions are challenging to access using the endoscopic endonasal approach because these regions are obstructed by the dorsum sellae and posterior clinoid processes. We evaluated the safety and clinical efficacy of endoscopic dorsum sellar resection (DSR) and identified the optimal indications for endoscopic DSR in patients with craniopharyngioma.

Methods: A retrospective study was conducted of patients who had undergone treatment with an endoscopic endonasal approach from January 2014 to January 2019. Read More

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Pituitary infundibular epidermoid cyst: a rare cause of hypopituitarism.

BMJ Case Rep 2021 Mar 24;14(3). Epub 2021 Mar 24.

Department of Endocrinology, University of Wales College of Medicine, Cardiff, UK.

A 53-year-old man presented with 6 months history of weight loss associated with nausea, fatigue, dizziness and headache. On arrival he was in adrenal crisis. Biochemistry revealed anterior hypopituitarism with low cortisol, thyroxine, testosterone and a slightly raised prolactin. Read More

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Impact of sleep, neuroendocrine, and executive function on health-related quality of life in young people with craniopharyngioma.

Dev Med Child Neurol 2021 Mar 22. Epub 2021 Mar 22.

Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Aim: To examine the impact of clinical factors, cognitive deficits, and sleepiness on health-related quality of life (HRQoL) among young people with craniopharyngioma.

Method: Seventy-eight patients (67% White; 41 males, 37 females; mean age 10y 8mo, SD 3y 11mo, range 6-20y) with craniopharyngioma were assessed for tumor extent and diabetes insipidus. All patients underwent overnight polysomnography and multiple sleep latency tests after surgical resection. Read More

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Beyond the bipolar disorder diagnosis: Hypothalamus and its network damage in determining neuropsychiatric and Korsakoff-like memory disorders.

Cortex 2021 May 17;138:178-190. Epub 2021 Feb 17.

Division of Neurosurgery, Neuroscience Department, San Camillo Hospital, Rome, Italy.

Craniopharyngiomas (CP's) are hypothalamic tumors often associated with psychological disorders. Nevertheless, its diagnosis is still challenging when psychiatric disorders are not associated with any other neurological symptoms. This single-case study describes a patient with a history of bipolar disorder before a diagnosis of a large CP arising the sellar and suprasellar region was posed. Read More

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Endoscopic Transcortical Transventricular Management of Cystic Craniopharyngioma: Outcome Analysis of 32 Cases at a Tertiary Care Center.

Asian J Neurosurg 2020 Oct-Dec;15(4):846-855. Epub 2020 Dec 21.

Department of Neurosurgery, King George's Medical University, Lucknow, Uttar Pradesh, India.

Background: Microsurgical resection has been considered the gold standard treatment of craniopharyngioma, but lately, it has found less favor due to its morbidity and is being replaced by minimally invasive cyst drainage procedures. We present our experience of transventricular endoscopy and cyst drainage along with its technique and have analyzed its results.

Materials And Methods: Clinical and radiological data of all cystic craniopharyngioma patients treated by transventricular endoscopic cyst drainage and Ommaya placement were retrieved and analyzed. Read More

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December 2020

The STAR/HOP system: a newly proposed abbreviated descriptive clinical coding system for craniopharyngiomas.

Childs Nerv Syst 2021 May 11;37(5):1473-1477. Epub 2021 Mar 11.

Pediatric Neurosurgery, Children's Cancer Hospital Egypt (CCHE-57357), 24, Faisal City, Miami, Alexandria, Egypt.

Craniopharyngiomas are complex and challenging tumors of the central nervous system (CNS) which require multidisciplinary and tailored management plans. An extensive variety of clinical presentations, treatment options, and patient outcomes exists. It is crucial to accurately and effectively distinguish the clinical status and the patient's specific roadmap to ensure proper disease status identification, patient-tailored care, follow-up, doctor-doctor and doctor-patient communication, and research. Read More

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