5,448 results match your criteria Craniopharyngioma


Dosimetric and volumetric outcomes of combining cyst puncture through an Ommaya reservoir with index-optimized hypofractionated stereotactic radiotherapy in the treatment of craniopharyngioma.

Clin Transl Radiat Oncol 2020 Jul 11;23:66-71. Epub 2020 May 11.

Department of Neurosurgery, University Hospital, Amiens, France.

Large cystic craniopharyngioma management combining cyst puncture through an Ommaya reservoir with hypofractionated stereotactic radiotherapy was evaluated. The planning optimization was focused on the gradient and selectivity. Punctured and filled cyst treatment plans were compared with a retrospective analysis of volumetric and functional outcomes. Read More

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http://dx.doi.org/10.1016/j.ctro.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256109PMC

See-saw nystagmus in giant craniopharyngioma.

BMJ Case Rep 2020 Jun 1;13(6). Epub 2020 Jun 1.

Vitreo-Retina, Sadguru Netra Chikitsalaya, Chitrakoot, India.

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http://dx.doi.org/10.1136/bcr-2020-235435DOI Listing

Prevalence of Endocrine and Metabolic Comorbidities in a National Cohort of Patients with Craniopharyngioma.

Horm Res Paediatr 2020 May 27:1-12. Epub 2020 May 27.

Department of Endocrinology, Diabetes and Metabolism, University Children's Hospital, University Medical Center Ljubljana, Ljubljana, Slovenia,

Objective: The major part of craniopharyngioma (CP) morbidity is the tumor and/or treatment-related damage, which results in impaired function of the hypothalamic-pituitary axes and metabolic derangements. The aim of the study was to analyze the prevalence of long-term endocrine and metabolic comorbidities in a national cohort of CP patients based on the age at diagnosis and histology criteria.

Design: A retrospective-prospective longitudinal cohort analysis. Read More

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http://dx.doi.org/10.1159/000507702DOI Listing

The implication of giant tumor size on surgical resection, oncological, and functional outcomes in craniopharyngioma.

Pituitary 2020 May 25. Epub 2020 May 25.

Department of Neurosurgery, Sri Chitra Tirunal Institute for Medical Science and Technology, Trivandrum, Kerala, India.

Objective: Implication of the tumor size on oncological and functional outcomes of craniopharyngioma is inconsistently reported. The aim of this study is to assess the postoperative outcome of giant craniopharyngiomas (> 4 cm in diameter) and to elucidate the impact of tumor size on various outcome parameters and survival.

Material And Methods: Forty-four patients (children aged ≤ 18 years: 25; adults: 16) with giant craniopharyngioma, operated between January 2001 and December 2015, were included in this study. Read More

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http://dx.doi.org/10.1007/s11102-020-01053-zDOI Listing

Craniopharyngiomas: experience and results.

Neurocirugia (Astur) 2020 May 20. Epub 2020 May 20.

Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Argentina.

Introduction: Craniopharyngiomas are a big challenge in the neurosurgical field. Because these lesions involve important systems, surgeons must weigh the risks of aggressive resection against the long-term challenges of recurrence. We present the outcomes of our patients based on clinical results, degree of resection, recurrence and disease-free survival. Read More

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http://dx.doi.org/10.1016/j.neucir.2020.03.008DOI Listing

Adamantinomatous craniopharyngioma in the molecular age and the potential of targeted therapies: a review.

Childs Nerv Syst 2020 May 22. Epub 2020 May 22.

Department of Neurosurgery, University of Colorado Hospital, Aurora, CO, USA.

Pediatric adamantinomatous craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Arising in the sellar/suprasellar region, they grow in close proximity to critical neurological and vascular structures and can result in significant neuroendocrine morbidity. First-line treatment often involves surgical resection with or without radiotherapy and has been associated with significant morbidity and poor quality of life outcomes. Read More

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http://dx.doi.org/10.1007/s00381-020-04677-5DOI Listing

Margin-free Fractionated Stereotactic Radiotherapy for Pediatric Brain Tumors.

Pract Radiat Oncol 2020 May 16. Epub 2020 May 16.

University of Texas - Southwestern, Department of Radiation Oncology, 2280 Inwood Rd, Dallas, TX 75390. Electronic address:

Background: Conventional radiotherapy (RT) to pediatric brain tumors exposes a large volume of normal brain to unwarranted radiation causing late toxicity. We hypothesized that in well demarcated pediatric tumors lacking microscopic extensions, fractionated stereotactic RT (SRT), without target volume expansions, can reduce high dose normal tissue irradiation without affecting local control.

Methods: Between 2008 and 2017, fifty-two pediatric patients with brain tumors were treated using the CyberKnife (CK) with SRT in 180-200 cGy/fraction. Read More

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http://dx.doi.org/10.1016/j.prro.2020.03.013DOI Listing

Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets.

Acta Neuropathol Commun 2020 May 13;8(1):68. Epub 2020 May 13.

Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, USA.

Adamantinomatous craniopharyngioma (ACP) is a biologically benign but clinically aggressive lesion that has a significant impact on quality of life. The incidence of the disease has a bimodal distribution, with peaks occurring in children and older adults. Our group previously published the results of a transcriptome analysis of pediatric ACPs that identified several genes that were consistently overexpressed relative to other pediatric brain tumors and normal tissue. Read More

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http://dx.doi.org/10.1186/s40478-020-00939-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222517PMC

A case report of an intra-optic recurrent craniopharyngioma.

Br J Neurosurg 2020 May 12:1-3. Epub 2020 May 12.

Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.

A 46-year old female patient presented with a left-sided superior temporal quadrantanopia due to a recurrent craniopharyngioma. The location of the recurrence was unusual. Imaging showed an enlarged left optic nerve, suggestive of a recurrent intra-optic craniopharyngioma. Read More

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http://dx.doi.org/10.1080/02688697.2020.1760207DOI Listing

Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report.

Neuro Oncol 2020 May 11. Epub 2020 May 11.

Department of Hematology and Oncology, Cincinnati Children's Hospital, Cincinnati, Ohio.

Background: Craniopharyngiomas account for approximately 1.2-4% of all CNS tumors. They are typically treated with a combination of surgical resection and focal radiotherapy. Read More

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http://dx.doi.org/10.1093/neuonc/noaa119DOI Listing

Sellar Tumors.

Surg Pathol Clin 2020 Jun;13(2):305-329

Department of Pathology and Immunology, Washington University in St. Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA. Electronic address:

Sellar region lesions include a broad range of benign and malignant neoplastic as well as non-neoplastic entities, many of which are newly described or have recently revised nomenclature. In contrast to other intracranial sites, imaging features are relatively less specific, and the need for histopathological diagnosis is of paramount importance. This review will describe pituitary adenomas, inflammatory lesions, and tumors unique to the region (craniopharyngioma) as well as tumors which may occur in but are not exclusively localized to the sellar location (schwannoma, metastasis, etc. Read More

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http://dx.doi.org/10.1016/j.path.2020.02.006DOI Listing

Pencil beam scanning proton therapy for the treatment of craniopharyngioma complicated with radiation-induced cerebral vasculopathies: a dosimetric and linear energy transfer (LET) evaluation.

Radiother Oncol 2020 May 5. Epub 2020 May 5.

Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland; Department of Radiation Oncology, University Hospital of Zürich, Zürich, CH-8000, Switzerland; Department of Radiation Oncology, University Hospital of Bern, Bern, CH-3010, Switzerland.

Background And Purpose: This study analyses the dosimetric and dose averaged Linear Energy transfer (LETd) correlation in paediatric craniopharyngioma (CP) patients with and without radiation-induced cerebral vasculopathies (RICVs) treated with pencil beam scanning (PBS) proton therapy (PT).

Material And Methods: We reviewed a series of 16 CP patients treated with PT to a median dose of 54 Gy(RBE). Two (12. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.04.052DOI Listing
May 2020
4.363 Impact Factor

Methylphenidate improves weight control in childhood brain tumor survivors with hypothalamic obesity.

Pediatr Blood Cancer 2020 Jul 8;67(7):e28379. Epub 2020 May 8.

Division of Diabetes and Endocrinology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas.

Background: Hypothalamic obesity causes unrelenting weight gain for childhood brain tumor survivors. No single therapy has proven effective for treatment. We aimed to evaluate effectiveness of long-term methylphenidate therapy on body mass index (BMI) change in children with hypothalamic obesity. Read More

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http://dx.doi.org/10.1002/pbc.28379DOI Listing

A rare case of giant cystic adamantinomatous craniopharyngioma in an adult.

Radiol Case Rep 2020 Jul 30;15(7):846-849. Epub 2020 Apr 30.

Department of Radiology, the First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen 518035, China.

Craniopharyngioma is an uncommon intracranial tumor that primarily occurs in the sella turcica. Giant cystic craniopharyngioma is rare in general and extremely rare in adults. We report a rare case of giant cystic craniopharyngioma in the anterior pontine cisterna and suprasellar cisterna. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200623PMC

Adamantinomatous Craniopharyngioma in an Adult: A Case Report with NGS Analysis.

Int Med Case Rep J 2020 21;13:123-137. Epub 2020 Apr 21.

Science and Technology Unit, Umm-Al-Qura University, Makkah, Saudi Arabia.

Purpose: Several recent studies have documented and mutations which are mutually exclusive for adamantinomatous craniopharyngioma (ACP) and papillary craniopharyngioma (PCP) tumors. This discovery is helpful in the development of novel targeted therapies in successful clinical trials with mutations in PCP cases. However, no such targeted therapy is available yet for ACP. Read More

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http://dx.doi.org/10.2147/IMCRJ.S243405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183340PMC

Analysis of 2141 pediatric craniopharyngioma admissions in the USA utilizing the Kids' Inpatient Database (KID): predictors of discharge disposition.

Childs Nerv Syst 2020 May 3. Epub 2020 May 3.

Department of Neurosurgery, Boston Children's Hospital - Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.

Objectives: To recognize the national trends in management of pediatric craniopharyngioma and to address the significant predictors of discharge disposition.

Methods: We utilized the Kids' Inpatient Database (KID), a pediatric inpatient sample generated by the Healthcare Cost and Utilization Project (HCUP) triennially from 1997 to 2016.

Results: KID contains 2141 pediatric craniopharyngioma admissions. Read More

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http://dx.doi.org/10.1007/s00381-020-04640-4DOI Listing

Predictors of narcolepsy and hypersomnia due to medical disorder in pediatric craniopharyngioma.

J Neurooncol 2020 Apr 28. Epub 2020 Apr 28.

Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

Purpose: Several studies describe sleep-wake disturbances in pediatric craniopharyngioma, but none have determined the prevalence or associated predictors of excessive sleepiness in this group after diagnosis and prior to post-operative observation or adjuvant radiotherapy. In this study, we report sleep-wake disturbances in children and adolescents with craniopharyngioma and associated clinical and treatment variables.

Methods: After surgery and prior to radiotherapy or observation, pediatric patients (n = 110) with craniopharyngioma ≥ 3 years old completed a baseline sleep clinic evaluation by a pediatric sleep specialist, polysomnography (PSG) and next-day multiple sleep latency test (MSLT). Read More

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http://dx.doi.org/10.1007/s11060-020-03519-3DOI Listing

Understanding treatment options in craniopharyngioma better.

Authors:
Songtao Qi

Nat Rev Dis Primers 2020 04 16;6(1):28. Epub 2020 Apr 16.

Department of Neurosurgery, and Nanfang Neurology Research Institution, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/s41572-020-0173-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162816PMC

Reply to: Understanding treatment options in craniopharyngioma better.

Nat Rev Dis Primers 2020 04 16;6(1):27. Epub 2020 Apr 16.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany.

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http://dx.doi.org/10.1038/s41572-020-0174-0DOI Listing

Pituitary Adenoma and Papillary Craniopharyngioma: A Rare Case of Collision Tumor and Review of the Literature.

World Neurosurg 2020 Apr 13;139:63-69. Epub 2020 Apr 13.

Pathology Departments, Hotel-Dieu de France Hospital, Achrafieh, Lebanon.

Background: Pituitary adenomas are the most common lesion of the sellar region. Very few cases in the literature have described their association with craniopharyngiomas in the same anatomic compartment, an entity defined as collision tumors of the sella.

Case Description: A 35-year-old man presented with headaches and progressive visual disturbances. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.088DOI Listing

Challenges, Learning Curve, and Safety of Endoscopic Endonasal Surgery of Sellar-Suprasellar Lesions in a Community Hospital.

World Neurosurg 2020 Apr 13. Epub 2020 Apr 13.

Neurosurgery Department, Windsor Regional Hospital, Western University, ON, Canada.

Background And Objective: Endoscopic endonasal surgery (EES) for the management of sellar, suprasellar, and anterior skull base lesions is gaining popularity. Our aim was to analyze and present the clinical outcomes of EES for the management of these lesions in a community hospital setting.

Methods: We retrospectively reviewed the charts of 56 patients with sellar, suprasellar, and anterior skull base lesions who underwent EES between 2010 and 2018. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195030PMC

Oxytocin release deficit and social cognition in craniopharyngioma patients.

J Neuroendocrinol 2020 May 15;32(5):e12842. Epub 2020 Apr 15.

Independent Max Planck Research Group for Social Neuroscience, Max Planck Institute of Psychiatry, Munich, Germany.

Oxytocin is a neuropeptide known to affect social behaviour and cognition. Craniopharyngioma patients are considered to have an oxytocin-release-deficit caused by a rare tumour affecting the pituitary and/or the hypothalamus relevant for oxytocin production and release. To assess social behaviour and socio-cognitive abilities in this patient group, we tested 13 patients and 23 healthy controls on self-report questionnaires and an eye-tracking paradigm including fast facial emotion recognition. Read More

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http://dx.doi.org/10.1111/jne.12842DOI Listing

Postoperative Long-term Outcomes of Patient with Craniopharyngioma Based on CyberKnife Treatment.

Cureus 2020 Mar 8;12(3):e7207. Epub 2020 Mar 8.

Neurosurgery, Moriyama Neurological Center Hospital, Tokyo, JPN.

Objective The results of CyberKnife treatment in patients with craniopharyngiomas are excellent, but reports of long-term follow-up are rare. Hence, considering the possibility of a long-term follow-up of five years or more, we examined the long-term prognoses of these patients. Materials and Methods Of 33 patients, 12 were males and 21 were females. Read More

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http://dx.doi.org/10.7759/cureus.7207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138486PMC

Cerebral venous sinus thrombosis following transsphenoidal surgery for craniopharyngioma: A case report.

World J Clin Cases 2020 Mar;8(6):1158-1163

Department of Emergency Medicine, Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, Shaanxi Province, China.

Background: Cerebral venous sinus thrombosis (CVST) is a rare condition in patients with craniopharyngioma following transsphenoidal surgery.

Case Summary: A 56-year-old man who underwent transsphenoidal surgery for craniopharyngioma 26 d ago presented gradual headache and cerebrospinal fluid leakage while vomiting 5 d post-discharge and required readmission to our department of neurosurgery. After admission, head imaging examination showed a hyperdense shadow in the superior sagittal sinus and right transverse sinus, edema at the bilateral parietal lobe, and hemorrhage at the left parietal lobe and right occipital lobe; the venous phase of cerebral angiography revealed CVST. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i6.1158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103970PMC

Suprasellar central nervous system ganglioneuroblastoma: a case in a 9-year-old child and review of the literature.

Childs Nerv Syst 2020 Apr 3. Epub 2020 Apr 3.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

Purpose: Intracranial ganglioneuroblastomas are incredibly rare neuroectodermal tumors with only 8 described cases total, 5 of those having imaging findings METHODS: Here we present a 9-year-old female patient with 4 months progressive headaches, personality changes, and vomiting. We also present a review of the current literature of intracranial ganglioneuroblastomas.

Results: Imaging demonstrated a partially calcified suprasellar mass measuring 4. Read More

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http://dx.doi.org/10.1007/s00381-020-04597-4DOI Listing

Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2010 to 2016.

Ann Saudi Med 2020 Mar-Apr;40(2):105-112. Epub 2020 Apr 2.

From the Department of Medicine, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates.

Background: The prevalence of sellar masses (SMs) is reported in Europe and North America but only limited data are available from the Middle East and North Africa (MENA) region.

Objectives: Assess the prevalence and characteristics of SMs in Al Ain city, United Arab Emirates.

Design: Retrospective, descriptive multicenter study. Read More

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http://dx.doi.org/10.5144/0256-4947.2020.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118230PMC

Expanded transnasal approaches to the skull base in the Middle East: Where do we stand?

Ann Saudi Med 2020 Mar-Apr;40(2):94-104. Epub 2020 Apr 2.

From the Division of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Endoscopic transnasal surgery has gained rapid global acceptance over the last two decades. The growing literature and understanding of anterior skull base endoscopic anatomy, in addition to new dedicated endoscopic instruments and tools, have helped to expand the use of the transnasal route in skull base surgery.

Objective: Report our early experience in expanded endoscopic transnasal surgery (EETS) and approach to skull base neoplasms. Read More

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http://dx.doi.org/10.5144/0256-4947.2020.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118227PMC
April 2020
0.705 Impact Factor

Hippocampal radiotherapy dose-constraints for predicting long-term neurocognitive outcomes: Mature data from a prospective trial in young patients with brain tumors.

Neuro Oncol 2020 Mar 30. Epub 2020 Mar 30.

Neuro Oncology Disease Management Group, Tata Memorial Centre, Parel, Mumbai, and Homi Bhaba National Institute, Mumbai.

Background: Hippocampus is considered to be the seat for neurocognitive functions. Avoidance of hippocampus during radiotherapy to brain may serve to preserve various domains of neurocognition. We aimed to derive radiotherapy dose constraints to hippocampi for preserving neurocognition in young patients with brain tumors by measuring various neurocognitive parameters. Read More

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http://dx.doi.org/10.1093/neuonc/noaa076DOI Listing

Gamma Knife Surgery for Residual or Recurrent Craniopharyngioma After Surgical Resection: A Multi-institutional Retrospective Study in Japan.

Cureus 2020 Feb 12;12(2):e6973. Epub 2020 Feb 12.

Neurosurgery, Shiroyama Hospital, Habikino, JPN.

Objective The optimal treatment for a craniopharyngioma has been controversial. Complete resection is ideal, but it has been difficult to obtain total resection in many cases because of intimate proximity to critical structures such as the optic pathway, hypothalamus, and pituitary gland. A growing number of studies have demonstrated the utility of radiosurgery in controlling residual or recurrent craniopharyngioma. Read More

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http://dx.doi.org/10.7759/cureus.6973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075476PMC
February 2020

Feasibility of primary human cell cultures as a model for adamantinomatous craniopharyngioma research: Evidence from RNA-Seq analysis.

Oncol Lett 2020 Mar 16;19(3):2346-2354. Epub 2020 Jan 16.

Department of Neurosurgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Adamantinomatous craniopharyngioma (ACP) is a benign epithelial tumor of the sellar region. Whether primary human cell cultures can be used as a stable research model has yet to be determined. The characteristics of three cultured craniopharyngioma primary cell (CPC) lines were identified using immunofluorescence. Read More

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http://dx.doi.org/10.3892/ol.2020.11309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039094PMC

The functional evaluation of pituitary in patients with a surgical resection of sellar tumours.

Arch Med Sci 2020 29;16(2):460-465. Epub 2019 Oct 29.

Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, China.

Introduction: The aim of this study was to analyse the incidences of hypopituitarism before and after surgical resection of sellar tumours and to find the factors related to the incidences.

Material And Methods: From January 2009 to December 2011, 191 patients in the Department of Neurosurgery in Xiangya Hospital, who underwent the surgical resection of sellar tumours, were included in this retrospective analysis. Pre- and postoperative pituitary function assessments were performed by the detection of hormone levels. Read More

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http://dx.doi.org/10.5114/aoms.2019.89356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069440PMC
October 2019

Galactose-modified duocarmycin prodrugs as senolytics.

Aging Cell 2020 Apr 16;19(4):e13133. Epub 2020 Mar 16.

MRC London Institute of Medical Sciences (LMS), London, UK.

Senescence is a stable growth arrest that impairs the replication of damaged, old or preneoplastic cells, therefore contributing to tissue homeostasis. Senescent cells accumulate during ageing and are associated with cancer, fibrosis and many age-related pathologies. Recent evidence suggests that the selective elimination of senescent cells can be effective on the treatment of many of these senescence-associated diseases. Read More

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http://dx.doi.org/10.1111/acel.13133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189988PMC

Second-hit APC mutation in a familial adamantinomatous craniopharyngioma.

Neuro Oncol 2020 Mar 12. Epub 2020 Mar 12.

Department and Laboratory of Inherited Endocrine Disorders, Endocrinology Research Centre, Moscow, Russian Federation.

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http://dx.doi.org/10.1093/neuonc/noaa060DOI Listing

[Analysis of misdiagnosis causes of suprasellar arachnoid cysts].

Zhonghua Yi Xue Za Zhi 2020 Mar;100(8):610-613

Department of Neurosurgery, Hebei Genral Hospital, Shijiazhuang 050051, China.

To investigate the causes of misdiagnosis of suprasellar arachnoid cysts, analyze its characteristics and put forward the diagnostic basis and differential points. The clinical data fo 97 cases of suprasellar arachnoid cysts diagnosed and treated in the neurosurgery department of Beijing Tiantan Hospital and Hebei General Hospital from March 2015 to March 2019 were analyzed retrospectively. All patients underwent CT and MRI scans with obstructive hydrocephalus. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2020.08.009DOI Listing

Radiomic Analysis of Craniopharyngioma and Meningioma in the Sellar/Parasellar Area with MR Images Features and Texture Features: A Feasible Study.

Contrast Media Mol Imaging 2020 18;2020:4837156. Epub 2020 Feb 18.

West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

Purpose: To investigate the ability of qualitative Magnetic Resonance (MR) images features and quantitative Magnetic Resonance Imaging (MRI) texture features in the contrastive analysis between craniopharyngioma and meningioma.

Method: A total number of 127 patients were included in this study (craniopharyngioma = 63; meningioma = 64). All the features analyzed in this study were acquired from preoperative MRI images. Read More

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http://dx.doi.org/10.1155/2020/4837156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049426PMC
February 2020

The advantages and disadvantages of sleeve gastrectomy; clinical laboratory to bedside review.

Heliyon 2020 Feb 29;6(2):e03496. Epub 2020 Feb 29.

Department of Surgery, Erfan Niayesh Hospital, Tehran, Iran.

Sleeve gastrectomy is a surgical technique and a leading method in metabolic surgery. Sleeve gastrectomy gained ever-increasing popularity among laparoscopic surgeons involved in bariatric surgery and has proved to be a successful method in achieving considerable weight loss in a short time. There are some disparate effects that patients may experience after sleeve gastrectomy including a reduction in BMI, weight, blood pressure, stroke, and cancer and also a significant remission in obesity-related diseases including type 2 diabetes (T2D), Non-alcoholic fatty liver (NAFLD), cardiovascular disease, obstructive sleep apnea, and craniopharyngioma-related hypothalamic obesity as well as non-obesity-related diseases such as gout, musculoskeletal problems, ovarian disorders and urinary incontinence. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052082PMC
February 2020

Clinical Characteristics of Pediatric Patients With Sellar and Suprasellar Lesions Who Initially Present With Central Diabetes Insipidus: A Retrospective Study of 55 Cases From a Large Pituitary Center in China.

Front Endocrinol (Lausanne) 2020 20;11:76. Epub 2020 Feb 20.

Department of Neurosurgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, China.

To increase knowledge for the early differential diagnosis and accurate therapeutic strategies for pediatric patients with sellar or suprasellar region (SSR) lesions who initially present with central diabetes insipidus (CDI). This is a retrospective review of 55 pediatric patients (≤14 years old) with identified lesions in the SSR who initially presented with CDI at a large pituitary center between 2012 and 2018. The following data were summarized: demographic, clinical, endocrine, and neuroimaging data, intraoperative findings, histopathological findings, treatments, and prognosis. Read More

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http://dx.doi.org/10.3389/fendo.2020.00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044264PMC
February 2020

Fractures, Bone Mineral Density, and Final Height in Craniopharyngioma Patients with a Follow-up of 16 Years.

J Clin Endocrinol Metab 2020 Apr;105(4)

Department of Medicine, Endocrinology; Erasmus Medical Center, GD Rotterdam, The Netherlands.

Context: Pituitary hormonal deficiencies in patients with craniopharyngioma may impair their bone health.

Objective: To investigate bone health in patients with craniopharyngioma.

Design: Retrospective cross-sectional study. Read More

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http://dx.doi.org/10.1210/clinem/dgz279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060760PMC

Rathke's cleft cyst presentation mimicking craniopharyngioma: Case report.

Int J Surg Case Rep 2020 6;68:104-106. Epub 2020 Feb 6.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Otolaryngology, Head & Neck Surgery King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Introduction: Rathke's cleft cysts (RCCs) are benign cystic lesions from the remnant cells of the craniopharyngeal duct within Rathke's pouch. Anticipation of such condition will help planning the treatment course.

Presentation Of Case: We present a case of a 46-year-old male, referred to our tertiary center with a history of seizures, confusion and agitation for the past two weeks. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.01.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056600PMC
February 2020

Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction.

Front Endocrinol (Lausanne) 2020 18;11:16. Epub 2020 Feb 18.

Department of Pediatrics, IRCCS Istituto Giannina Gaslini, University of Genova, Genova, Italy.

To detect the presence of antipituitary (APA) and antihypothalamus antibodies (AHA) in subjects treated for brain cancers, and to evaluate their potential association with pituitary dysfunction. We evaluated 63 patients with craniopharyngioma, glioma, and germinoma treated with surgery and/or radiotherapy and/or chemotherapy at a median age of 13 years. Forty-one had multiple pituitary hormone deficiencies (MPHD), six had a single pituitary defect. Read More

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http://dx.doi.org/10.3389/fendo.2020.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040196PMC
February 2020

India's First Proton Beam Therapy Pediatric Patient.

Neurol India 2020 Jan-Feb;68(1):189-191

Department of Radiation, Apollo Proton Cancer Center, Chennai, Tamil Nadu, India.

We recently started India's first proton beam therapy facility. Proton beam therapy because of its unique physical characteristics of minimal exit dose has an unequivocal dosimetric superiority over high-end photon/standard X-ray beam therapy and is particularly advantageous in growing children with curable cancers in view of their very high probability of long-term cures. We hereby report a case of a 7-year-old boy with a craniopharyngioma which had been subtotally resected and was subsequently treated with modern pencil beam proton therapy under high-precision image guidance. Read More

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http://dx.doi.org/10.4103/0028-3886.279686DOI Listing

Biological Behaviour of Craniopharyngiomas.

Neuroendocrinology 2020 Mar 4. Epub 2020 Mar 4.

Jacob Erdheim (1874-1937) first described craniopharyngioma (CP) as "hypophyseal duct tumours" and postulated the existence of two tumour types based on their histological features: (1) an aggressive type showing similarities to adamantinomas (tumours of the jaw) and (2) a more benign form characterised by the presence of papillary structures. More than a century later, these initial observations have been confirmed; based on their distinct genetic, epigenetic and histological features, the WHO classify CPs as two types, papillary (PCP) and adamantinomatous (ACP). Considerable knowledge has been generated on the biology of CPs in the last 20 years. Read More

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http://dx.doi.org/10.1159/000506904DOI Listing

CTNNB1 mutations are clonal in adamantinomatous craniopharyngioma.

Neuropathol Appl Neurobiol 2020 Mar 3. Epub 2020 Mar 3.

Developmental Biology and Cancer Research and Teaching Department, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1111/nan.12613DOI Listing

Pituitary surgery's epidemiology using a national inpatient database in Japan.

Acta Neurochir (Wien) 2020 Jun 3;162(6):1317-1323. Epub 2020 Mar 3.

Department of Neurological Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.

Background: Between 2010 and 2014, microscopic transsphenoidal surgery (mTSS) was performed more frequently than endoscopic TSS (eTSS) in the USA. However, few epidemiological studies on pituitary surgery are currently available.

Methods: We performed a retrospective study on patients who had undergone pituitary surgery between July 2010 and March 2016. Read More

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http://dx.doi.org/10.1007/s00701-020-04270-4DOI Listing

Surgical management of craniopharyngiomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section.

Acta Neurochir (Wien) 2020 May 28;162(5):1159-1177. Epub 2020 Feb 28.

Department of Neurosurgery, University Hospital of Lausanne, Lausanne, Switzerland.

Background And Objective: Craniopharyngiomas are locally aggressive neuroepithelial tumors infiltrating nearby critical neurovascular structures. The majority of published surgical series deal with childhood-onset craniopharyngiomas, while the optimal surgical management for adult-onset tumors remains unclear. The aim of this paper is to summarize the main principles defining the surgical strategy for the management of craniopharyngiomas in adult patients through an extensive systematic literature review in order to formulate a series of recommendations. Read More

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http://dx.doi.org/10.1007/s00701-020-04265-1DOI Listing
May 2020
1.788 Impact Factor

Growth Hormone Therapy Does Not Increase the Risk of Craniopharyngioma and Nonfunctioning Pituitary Adenoma Recurrence.

J Clin Endocrinol Metab 2020 May;105(5)

Endocrinology Unit, Department of Internal Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Context: Recombinant human growth hormone (rhGH) replacement therapy is often prescribed in patients with nonfunctioning pituitary adenoma (NFPA) or craniopharyngioma.

Objective: To study whether rhGH therapy in patients with adult growth hormone deficiency (AGHD) increases the risk of pituitary tumor recurrence.

Design: Retrospective, observational study. Read More

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http://dx.doi.org/10.1210/clinem/dgaa089DOI Listing

Catastrophic vision loss from radiation-induced optic neuropathy.

BMJ Case Rep 2020 Feb 26;13(2). Epub 2020 Feb 26.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada

A 68-year-old woman presented with profound vision loss of 2-month duration in the right eye and 1-week duration in her left eye. This occurred in the context of craniopharyngioma that was twice resected and irradiated (54 Gy in 30 fractions) 9 months before her presentation. Ophthalmological examination revealed hand motion vision in the right eye and light perception vision in the left eye with poorly reactive pupils and bilateral optic disc pallor. Read More

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http://dx.doi.org/10.1136/bcr-2019-233706DOI Listing
February 2020