5,209 results match your criteria Craniopharyngioma


Intrachiasmatic craniopharyngioma: Assessment of visual outcome with optical coherence tomography after complete surgical removal.

Surg Neurol Int 2019 21;10. Epub 2019 Jan 21.

Department of Neurosurgery, La Princesa University Hospital, Madrid, Spain.

Background: Optic chiasm invasion by a craniopharyngioma (CP) is exceptional. Surgical treatment of intrachiasmatic CPs associates a high risk of chiasm injury, which should be properly addressed before surgery.

Case Description: We present a 46-year-old woman admitted to the hospital with low visual acuity (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/sni.sni_292_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357539PMC
January 2019

Efficacy of Direct Revascularization Surgery for Hemorrhagic Moyamoya Syndrome As a Late Complication of Cranial Irradiation for Childhood Craniopharyngioma.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Tohoku University, Sendai, Japan.

Moyamoya syndrome (MMS) is an uncommon late complication after cranial irradiation. Its hemorrhagic presentation from the associated pseudo-aneurysm is extremely rare, and the optimal management strategy is undetermined. We herein report a 36-year-old man who developed intraventricular hemorrhage from a pseudo-aneurysm at the extended left anterior choroidal artery as an abnormal collateral of MMS 30 years after surgical removal and cranial irradiation for childhood craniopharyngioma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.033DOI Listing
February 2019
1 Read

Expanded Endonasal Endoscopic Surgery in Suprasellar Craniopharyngiomas: A Retrospective Analysis of 43 Surgeries Including Recurrent Cases.

Oper Neurosurg (Hagerstown) 2019 Feb 15. Epub 2019 Feb 15.

Division of Neurosurgery, Toronto Western Hospital, University Health Network and Department of Surgery, University of Toronto, Toronto, Canada.

Background: The role of expanded endonasal endoscopic surgery for primary and recurrent craniopharyngioma is not yet fully established.

Objective: To report and evaluate our experience with the endoscopic endonasal approach (EEA) for the resection of primary and recurrent craniopharyngiomas.

Methods: This is a retrospective cohort analysis of 43 consecutive EEA procedures in 40 patients operated from September 2006 to February 2012 for suprasellar craniopharyngiomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ons/opy356DOI Listing
February 2019
1 Read

Awake Surgical Management of Third Ventricular Tumors: A Preliminary Safety, Feasibility, and Clinical Applications Study.

Oper Neurosurg (Hagerstown) 2019 Feb 12. Epub 2019 Feb 12.

Aurora Neuroscience Innovation Institute, Aurora St. Luke's Medical Center, Milwaukee, Wisconsin.

Background: Endoscopic and microneurosurgical approaches to third ventricular lesions are commonly performed under general anesthesia.

Objective: To report our initial experience with awake transsulcal parafascicular corridor surgery (TPCS) of the third ventricle and its safety, feasibility, and limitations.

Methods: A total of 12 cases are reviewed: 6 colloid cysts, 2 central neurocytomas, 1 papillary craniopharyngioma, 1 basal ganglia glioblastoma, 1 thalamic glioblastoma, and 1 ependymal cyst. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ons/opy405DOI Listing
February 2019
1 Read

Subfrontal Infrachiasmatic Approach to a Craniopharyngioma Resection: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2019 Feb 5. Epub 2019 Feb 5.

Division of Pediatric Neurosurgery, Department of Surgery, Texas Children's Hospital, Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.

Craniopharyngioma constitutes one of the most challenging tumors. The surgery may be the definitive treatment and multiple approaches have been described based on different anatomical considerations. The choice of the right approach is the key to optimize the resection and minimize the risks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ons/opy403DOI Listing
February 2019

Lessons learned in the evolution of endoscopic skull base surgery.

J Neurosurg 2019 Feb;130(2):337-346

2Otorhinolaryngology, NewYork-Presbyterian Hospital/Weill Cornell Medicine, New York; and.

OBJECTIVEEndoscopic skull base surgery (ESBS) is a relatively recent addition to the neurosurgical armamentarium. As with many new approaches, there has been significant controversy regarding its value compared with more traditional approaches to ventral skull base pathology. Although early enthusiasm for new approaches that appear less invasive is usually high, these new techniques require rigorous study to ensure that widespread implementation is in the best interest of patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.10.JNS182154DOI Listing
February 2019
1 Read

In Reply to the Letter to the Editor "Craniopharyngioma: 10 Selected Works Which Provide Comprehensive and Valuable Insight into These Complex Tumors".

World Neurosurg 2019 02;122:713-714

Department of Neurological Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois, USA; Department of Otolaryngology, Loyola University Stritch School of Medicine, Maywood, Illinois, USA; Department of Neurological Surgery, Edward Hines, Jr. VA Hospital, Hines, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.10.223DOI Listing
February 2019
1 Read
2.417 Impact Factor

Craniopharyngioma: 10 Selected Works That Provide Comprehensive and Valuable Insight into These Complex Tumors.

World Neurosurg 2019 02;122:710-712

Department of Neurosurgery, Ramón y Cajal University Hospital, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.09.220DOI Listing
February 2019

[Clinical analysis of endoscopic endonasal approach for removal of sellar tumors].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;32(22):1735-1739

Department of Radiology, Tianjin Huanhu Hospita.

To investigate the safety and efficacy of endoscopic endonasal approach for removal of sellar tumors. The clinical data of 18 patients with sellar tumors undergoing endoscopic endonasal surgery were analyzed retrospectively. This series consisted of ten pituitary adenomas, five craniopharyngiomas, three meningiomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13201/j.issn.1001-1781.2018.22.013DOI Listing
November 2018
2 Reads

Patterns of Care in Pediatric Craniopharyngioma: Outcomes Following Definitive Radiotherapy.

Anticancer Res 2019 Feb;39(2):803-807

Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, U.S.A.

Background/aim: Few data are available on the utility of definitive radiation therapy (RT) for pediatric craniopharyngioma. This study sought to evaluate practice patterns and patient outcomes using the Surveillance Epidemiology and End Results database from 2004-2014.

Materials And Methods: Overall survival (OS) was compared between five treatment groups, definitive radiation therapy (RT), gross total resection (GTR), subtotal resection (STR), STR+RT, and observation/biopsy only, using Kaplan-Meier analysis and log-rank tests. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13178DOI Listing
February 2019
1 Read

Adipsic diabetes insipidus secondary to craniopharyngioma resection.

BMJ Case Rep 2019 Jan 31;12(1). Epub 2019 Jan 31.

Fundación Cardioinfantil Instituto de Cardiologia, Bogotá, Colombia.

Adipsic diabetes insipidus is an infrequent disease which may be associated with craniopharyngioma. It may be secondary to the tumour's extension, as well as to resection of the mass. We present the case of a 24-year-old woman with a history of delayed puberty and hypothyroidism, but no prior study reports. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-225903DOI Listing
January 2019
1 Read

A Case of Primary Sellar Paraganglioma: Immunohistochemistry Resource and Review.

World Neurosurg 2019 Jan 28. Epub 2019 Jan 28.

Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, 5841 S. Maryland Avenue, Chicago, IL. Electronic address:

Background: The differential diagnosis of sellar masses includes adenoma, meningioma, craniopharyngioma, and metastasis. Seldom is primary paraganglioma considered. Here we present a case of this unique pathology, review the relevant literature and compile a compendium of immunohistochemical characteristics for use as a resource. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.01.094DOI Listing
January 2019
1 Read

Comparative evaluation of neuroendocrine dysfunction in children with craniopharyngiomas before and after mass effects are removed.

J Pediatr Endocrinol Metab 2019 Feb;32(2):127-133

Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China, Phone: +13661307913.

Objective To compare the effects of mass effects in situ (MEIS) and after neurosurgery (ANS) on neuroendocrine function in children with craniopharyngioma. Methods We retrospectively investigated 185 cases of children with craniopharyngioma who underwent neurosurgical treatment at the Beijing Tiantan Hospital from 2011 to 2016. The neuroendocrine function of patients was compared before and after tumor removal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/jpem-2018-0204DOI Listing
February 2019
1 Read

Growth hormone replacement therapy improves hypopituitarism-associated hypoxemia in a patient after craniopharyngioma surgery: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14101

Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China.

Rationale: There are some reports about hypoxemia related to hypopituitarism. However, little is known about the relationship between growth hormone deficiency (GHD) and hypoxemia.

Patients Concerns: A 23-year-old female presented with severe hypoxemia after the operations of craniopharyngioma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014101DOI Listing
January 2019
2 Reads

Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas.

Exp Ther Med 2019 Jan 12;17(1):51-56. Epub 2018 Nov 12.

Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China.

Craniopharyngiomas (CPs) are rare epithelial tumors mainly located in the sellar/parasellar region. They may be classified into two major histological subtypes, which exhibit clinical and pathological differences: Adamantinomatous CP (ACP) and papillary CP (PCP). The aim of the present study was to compare the neuroendocrine dysfunction between ACP and PCP prior to and after surgical resection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2018.6953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307520PMC
January 2019
1 Read

Clinical and Radiographic Characteristics of Atypical Slipped Capital Femoral Epiphysis.

J Pediatr Orthop 2019 Jan 14. Epub 2019 Jan 14.

Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Slipped capital femoral epiphysis (SCFEs) can be idiopathic or atypical (associated with renal failure, radiation therapy, and endocrine disorders). It is important to estimate the likelihood that atypical SCFE shows different clinical and radiographic characteristics and complications with typical SCFEs.

Methods: We retrospectively reviewed 53 patients (66 hips) with SCFEs managed between 1995 and 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BPO.0000000000001339DOI Listing
January 2019
6 Reads

SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma.

Endocr Relat Cancer 2019 Jan 1. Epub 2019 Jan 1.

J Martinez-Barbera, Institute of Child Health, Developmental Biology and Cancer Programme Birth Defects Research Centre, University College London, 30 Guilford Street , London, United Kingdom of Great Britain and Northern Ireland.

Pharmacological inhibition of the sonic hedgehog (SHH) pathway can be beneficial against certain cancers but detrimental in others. Adamantinomatous craniopharyngioma (ACP) is a relevant pituitary tumour, affecting children and adults, that is associated with high morbidity and increased mortality in long-term follow up. We have previously demonstrated overactivation of the SHH pathway in both human and mouse ACP. Read More

View Article

Download full-text PDF

Source
https://erc.bioscientifica.com/view/journals/erc/aop/erc-18-
Publisher Site
http://dx.doi.org/10.1530/ERC-18-0538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378366PMC
January 2019
4 Reads

Long-term impact of pediatric endoscopic endonasal skull base surgery on midface growth.

J Neurosurg Pediatr 2019 Jan 11:1-8. Epub 2019 Jan 11.

Departments of1Plastic Surgery.

OBJECTIVECranial base development plays a large role in anterior and vertical maxillary growth through 7 years of age, and the effect of early endonasal cranial base surgery on midface growth is unknown. The authors present their experience with pediatric endoscopic endonasal surgery (EES) and long-term midface growth.METHODSThis is a retrospective review of cases where EES was performed from 2000 to 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.8.PEDS18183DOI Listing
January 2019
2 Reads

Management of Craniopharyngioma.

J Craniofac Surg 2019 Jan 10. Epub 2019 Jan 10.

Department of Pathology, Şişli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Objective: Craniopharyngiomas are one of the most challenging problems for neurosurgeons because of the high recurrence rates due to their localization and associated endocrinological disorders. This study reports the outcomes of surgeries and recurrence rates of 45 craniopharyngioma cases.

Method: Patients who were diagnosed with craniopharyngioma in the authors' clinic between 1998 and 2016 evaluated retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SCS.0000000000005136DOI Listing
January 2019
5 Reads

[Psychosis and behavioural problems as first symptoms of brain tumour?]

Authors:
J Schildermans

Tijdschr Psychiatr 2019 ;61(1):53-56

A craniopharyngioma is a rare, slow-growing tumour in the pituitary gland. Brain tumours usually present with obvious neurological or other physical symptoms, whereas psychiatric symptoms as primary signs are rare. The presented case, in which psychosis and behavioural problems predominated, concerned a 42-year-old patient. Read More

View Article

Download full-text PDF

Source
January 2019
1 Read

Supplemental Glucocorticoids and Anesthesia for Non-Invasive Indications in Children with Central Adrenal Insufficiency: A Retrospective Study.

Paediatr Anaesth 2019 Jan 10. Epub 2019 Jan 10.

Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, USA.

Adrenal insufficiency is characterized by the deficiency of circulating adrenocortical hormones and can be primary or central. Primary adrenal insufficiency is due to disease of the adrenal cortex, central adrenal insufficiency to a deficit in hypothalamic/pituitary secretion of adrenocorticotropic hormone. Patients with adrenal insufficiency require basal steroid replacement and need supplemental glucocorticoids (GC) during periods of medical stress. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pan.13586
Publisher Site
http://dx.doi.org/10.1111/pan.13586DOI Listing
January 2019
10 Reads

Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy.

Neuro Oncol 2019 Jan 8. Epub 2019 Jan 8.

Department of Radiation Oncology, St. Jude Children's Research Hospital.

Background: Pediatric patients with brain tumors who are treated with radiation therapy (RT) are at risk for neurocognitive and psychosocial late effects. Research to date has primarily examined these outcomes at a group level and in isolation. Advanced statistical techniques allow for person-centered analyses, as well as examination of relationships between domain-specific trajectories. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/neuro-oncology/advance-article/doi/
Publisher Site
http://dx.doi.org/10.1093/neuonc/noz010DOI Listing
January 2019
5 Reads

Noninvasive molecular diagnosis of craniopharyngioma with MRI-based radiomics approach.

BMC Neurol 2019 Jan 7;19(1). Epub 2019 Jan 7.

Department of Electronic Engineering, Fudan University, Shanghai, China.

Background: Frequent somatic mutations of BRAF and CTNNB1 were identified in both histological subtypes of craniopharyngioma (adamantinomatous and papillary) which shed light on target therapy to cure this oncogenic disease. The aim of this study was to investigate the noninvasive MRI-based radiomics diagnosis to detect BRAF and CTNNB1 mutations in craniopharyngioma patients.

Methods: Forty-four patients pathologically diagnosed as adamantinomatous craniopharyngioma (ACP) or papillary craniopharyngioma (PCP) were retrospectively studied. Read More

View Article

Download full-text PDF

Source
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
Publisher Site
http://dx.doi.org/10.1186/s12883-018-1216-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322318PMC
January 2019
6 Reads

Management of hypothalamic disease in patients with craniopharyngioma.

Clin Endocrinol (Oxf) 2019 Jan 4. Epub 2019 Jan 4.

Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland.

Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/cen.13929
Publisher Site
http://dx.doi.org/10.1111/cen.13929DOI Listing
January 2019
3 Reads

Endoscopic Endonasal Surgery for Craniopharyngiomas: A Series of 60 Patients.

World Neurosurg 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurosurgery, First Affiliated Hospital, Chongqing Medical University, Yuzhong District, Chongqing, P.R. China. Electronic address:

Objective: To report our experience of the management of 60 patients with craniopharyngioma with endoscopic endonasal surgery (EES) and evaluate the feasibility and safety of EES for craniopharyngiomas.

Methods: The clinical data of 60 patients with craniopharyngioma who underwent EES between November 2014 and December 2017 were analyzed retrospectively. All patients had vascularized nasoseptal flaps, and the most recent 4 patients had "in situ bone flaps" for better skull base reconstruction. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750183293
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.12.110DOI Listing
January 2019
7 Reads

Recurrence of Ventral Skull Base Lesions Attributed to Tumor Seeding: A Systematic Review.

World Neurosurg 2018 Dec 31. Epub 2018 Dec 31.

Department of Otolaryngology, William Beaumont Hospital, Royal Oak, Michigan, USA; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA.

Objective: To evaluate ventral skull base lesion recurrences along surgical access pathways attributed to iatrogenic seeding.

Methods: A systematic review of the literature was performed searching for recurrence of ventral skull base lesions attributed to iatrogenic implantation. Studies were assessed for level of evidence. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750183292
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.12.104DOI Listing
December 2018
11 Reads

Stature-weight growth delays: Clinical and etiological aspects.

J Family Med Prim Care 2018 Sep-Oct;7(5):963-966

Department of Endocrinology, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco.

Background: Stature-weight growth delay (SWGD) is a frequent motivation of consultation. It could be a consequence of a known chronic affection, congenital or acquired affection. The purpose of this study is to describe epidemiological, clinical, paraclinical, and etiological aspects of SWGD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jfmpc.jfmpc_207_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259559PMC
January 2019
1 Read

Craniopharyngiomas and odontogenic tumors mimic normal odontogenesis and share genetic mutations, histopathologic features, and molecular pathways activation.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Mar 16;127(3):231-236. Epub 2018 Nov 16.

Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Odontogenic tumors bear some histopathologic and molecular resemblance to craniopharyngiomas. Specifically, adamantinomatous craniopharyngioma shares morphologic features and CTNNB1 (the gene encoding β-catenin) mutations with calcifying odontogenic cyst, whereas papillary craniopharyngioma and ameloblastoma are driven by BRAF mutations. Recently, important similarities between adamantinomatous craniopharyngioma and the cell signaling pathways involved in tooth formation have been described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2018.11.004DOI Listing

"Radiation-induced moyamoya syndrome after proton therapy in a child with clival craniopharyngioma: natural history and surgical treatment".

World Neurosurg 2018 Dec 21. Epub 2018 Dec 21.

Department of Neurosurgery, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, 5, 16147, Genoa, Italy.

Background: Proton therapy has proven to be effective and safe in the treatment of radioresistant skull base tumors such as chordomas. Thanks to the peculiar physical properties of the proton beam, the radiation energy is delivered in a narrow space called the Bragg peak and the surrounding normal tissues receive a minimal amount of the radiation dose. This is important to lower the risk of radiation-induced damage, especially in children. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750183287
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.12.048DOI Listing
December 2018
20 Reads

Excess mortality after craniopharyngioma treatment: are we making progress?

Authors:
Nidan Qiao

Endocrine 2018 Dec 19. Epub 2018 Dec 19.

Department of Neurosurgery, Huashan Hospital, Shanghai, China.

Purpose: Craniopharyngioma is associated with an increased risk of mortality even after surgical, radiotherapeutic and hormone supplementations. Previous studies using different designs showed a possible trend of decreasing mortality in recent years. This review summarises studies reporting standardised mortality ratio (SMR) after craniopharyngioma treatment, as well as the bias and confounding in these studies to plan further researches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-018-1830-yDOI Listing
December 2018
1 Read

Commentary: A Clinical Rule for Preoperative Prediction of BRAF Mutation Status in Craniopharyngioma.

Authors:
Daniel W Fults

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuros/nyy614DOI Listing
December 2018
5 Reads

Proton therapy for treatment of intracranial benign tumors in adults: A systematic review.

Cancer Treat Rev 2019 Jan 1;72:56-64. Epub 2018 Dec 1.

Radiation Oncology Department, Centre François Baclesse, Caen, France; Archade, Advanced Resource Center for Hadrontherapy in Europe, Caen, France; Normandy University, Université de Caen Basse Normandie, Caen, France; Laboratoire de Physique Corpusculaire, Caen, France.

Introduction: The depth-dose distribution of a proton beam, materialized by the Bragg peak makes it an attractive radiation modality as it reduces exposure of healthy tissues to radiations, compared with photon therapy Prominent indications, based on a long-standing experience are: intraocular melanomas, low-grade skull-base and spinal canal malignancies. However, many others potential indications are under investigations such as the benign morbid conditions that are compatible with an extended life-expectancy: low grade meningiomas, paragangliomas, pituitary adenomas, neurinomas craniopharyngioma or recurrent pleomorphic adenomas.

Materials: Given the radiation-induced risk of secondary cancer and the potential neurocognitive and functional alteration with photonic radiotherapy, we systematically analyzed the existing clinical literature about the use of proton therapy as an irradiation modality for cervical or intracranial benign tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctrv.2018.11.004DOI Listing
January 2019
2 Reads

Superficial siderosis associated with craniopharyngioma: a rare case report.

World Neurosurg 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.

Superficial siderosis (SS) associated with craniopharyngioma is an extremely rare occurrence. To our knowledge, only three cases have been reported in literature. Two of the cases occurred following resection of the tumor. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750183278
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.11.222DOI Listing
December 2018
5 Reads

Lack of Sphenoid Pneumatization Does Not Affect Endoscopic Endonasal Pediatric Skull Base Surgery Outcomes.

Laryngoscope 2018 Dec 5. Epub 2018 Dec 5.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Objectives/hypothesis: Currently, due to the rarity of pathology, there are limited data surrounding outcomes of pediatric skull base surgery. Traditionally, surgeons have proceeded with caution when electing endonasal endoscopic transsellar/transplanum approaches to the skull base in pediatric patients due to poor sphenoid pneumatization. In this study, we review outcomes of endoscopic pediatric skull base surgery based on sphenoid pneumatization patterns. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.27600DOI Listing
December 2018
3 Reads

Oxytocin therapy in hypopituitarism: Challenges and opportunities.

Clin Endocrinol (Oxf) 2019 Feb 17;90(2):257-264. Epub 2018 Dec 17.

Schools of Medicine (RB, DAR) and Psychology (KLD), Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.

Patients with hypopituitarism display impaired quality of life and excess morbidity and mortality, despite apparently optimal pituitary hormone replacement. Oxytocin is a neuropeptide synthesized in the anterior hypothalamus which plays an important role in controlling social and emotional behaviour, body weight and metabolism. Recent studies have suggested that a deficiency of oxytocin may be evident in patients with hypopituitarism and craniopharyngioma, and that this may be associated with deficits in cognitive empathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13909DOI Listing
February 2019
3 Reads

Harvey Cushing's craniopharyngioma treatment: Part 1. Identification and clinicopathological characterization of this challenging pituitary tumor.

J Neurosurg 2018 Oct 1:1-15. Epub 2018 Oct 1.

3Statistics Department, Computing Center, CSIC, Madrid, Spain.

OBJECTIVEHarvey Cushing (1869-1939) coined the term "craniopharyngioma" (CP) in 1929 to describe a kaleidoscopic group of epithelial tumors involving the hypothalamic-pituitary axis. Throughout his career, he endured a long struggle to accurately diagnose and safely remove these complex lesions, and his resulting surgical series has never before been analyzed in depth. The authors here conduct such an analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.5.JNS18153DOI Listing
October 2018
1 Read

Harvey Cushing's craniopharyngioma treatment: Part 2. Surgical strategies and results of his pioneering series.

J Neurosurg 2018 Oct 1:1-15. Epub 2018 Oct 1.

3Statistics Department, Computing Center, CSIC, Madrid, Spain.

OBJECTIVEHarvey Cushing (1869-1939) developed pioneering surgical techniques for craniopharyngioma (CP) removal. This study exhaustively analyzes the pathological variables and surgical strategies that influenced Cushing's results in his entire series of CP patients.METHODSThe CP records from Cushing's Brain Tumor Registry were carefully reviewed, as were his CP cases published in medical monographs and scientific reports. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.5.JNS18154DOI Listing
October 2018
1 Read

Preserve or sacrifice the stalk? Endocrinological outcomes, extent of resection, and recurrence rates following endoscopic endonasal resection of craniopharyngiomas.

J Neurosurg 2018 Nov 1:1-9. Epub 2018 Nov 1.

Departments of1Neurological Surgery.

OBJECTIVEGross-total resection (GTR) of craniopharyngiomas (CPs) is potentially curative and is often the goal of surgery, but endocrinopathy generally results if the stalk is sacrificed. In some cases, GTR can be attempted while still preserving the stalk; however, stalk manipulation or devascularization may cause endocrinopathy and this strategy risks leaving behind small tumor remnants that can recur.METHODSA retrospective review of a prospective cohort of patients who underwent initial resection of CP using the endoscopic endonasal approach over a period of 12 years at Weill Cornell Medical College, NewYork-Presbyterian Hospital, was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.6.JNS18901DOI Listing
November 2018
1 Read

Endonasal endoscopic transsphenoidal resection of intrinsic third ventricular craniopharyngioma: surgical results.

J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.

1Department of Neurological Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York.

OBJECTIVEIntrinsic third ventricular craniopharyngiomas (IVCs) have been reported by some authors to "pose the greatest surgical challenge" of all craniopharyngiomas (CPAs). A variety of open microsurgical approaches have historically been used for resection of these tumors. Despite increased utilization of the endoscopic endonasal approach (EEA) for resection of CPAs in recent years, many authors continue to recommend against use of the EEA for resection of IVCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.5.JNS18198DOI Listing
November 2018
11 Reads

A modern series of subdiaphragmatic craniopharyngiomas.

J Neurosurg 2018 Oct 1:1-6. Epub 2018 Oct 1.

6Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

OBJECTIVEThe endoscopic endonasal approach has been proposed as a primary surgical strategy for select craniopharyngiomas. However, those tumors that arise from the sella have not been classified with the other craniopharyngioma subtypes in terms of surgical nuances, intraoperative findings, and postoperative outcomes. The authors describe their experience with a select subtype of craniopharyngioma arising within the sella subjacent to the diaphragma sellae and refer to these tumors as type 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.4.JNS172330DOI Listing
October 2018
12 Reads

Use of intraoperative intracavitary (direct-contact) ultrasound for resection control in transsphenoidal surgery for pituitary tumors: evaluation of a microsurgical series.

Acta Neurochir (Wien) 2019 Jan 27;161(1):109-117. Epub 2018 Nov 27.

Department of Neurosurgery, Johannes Wesling Klinikum, University Hospital of Ruhr-Universität Bochum, Hans Nolte Str. 1, 32429, Minden, Germany.

Background: Perisellar infiltration may be responsible for incomplete removal of pituitary tumors. Since intraoperative visualization of parasellar structures is difficult during transsphenoidal surgery, we are describing the use of intraoperative direct contact ultrasound (IOUS).

Methods: Within 5 years, in 113 transsphenoidal operations (58 male, 55 female, age 14-81 years, 110 pituitary adenomas (mean diameter 26. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00701-018-3747-xDOI Listing
January 2019
7 Reads

A Clinical Rule for Preoperative Prediction of BRAF Mutation Status in Craniopharyngiomas.

Neurosurgery 2018 Nov 27. Epub 2018 Nov 27.

Divisions of Neuro-Oncology and Hematology/Oncology, Departments of Medicine and Neurology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.

Background: Papillary craniopharyngiomas are characterized by BRAFV600E mutations. Targeted therapy can elicit a dramatic radiographic regression of these tumors. Therefore, prediction of BRAF mutation status before definitive surgery could enable neoadjuvant treatment strategies. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/neurosurgery/advance-article/doi/10
Publisher Site
http://dx.doi.org/10.1093/neuros/nyy569DOI Listing
November 2018
11 Reads

Periostin concentrations in childhood-onset craniopharyngioma patients.

J Endocrinol Invest 2018 Nov 24. Epub 2018 Nov 24.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, 26133, Oldenburg, Germany.

Purpose: Periostin is highly expressed in craniopharyngioma (CP)-associated fibroblasts and has been identified as a marker for non-alcoholic fatty liver disease (NAFLD). Half of CP patients with hypothalamic syndrome develop NAFLD. We hypothesized that periostin concentration is elevated in biological fluids of CP and associated with pathological hepatic parameters, indicating increased risk for NAFLD. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40618-018-0987-9
Publisher Site
http://dx.doi.org/10.1007/s40618-018-0987-9DOI Listing
November 2018
8 Reads

Quality of Life Changes Before and After Transsphenoidal Surgery for Sellar and Parasellar Lesions.

World Neurosurg 2019 Feb 14;122:e1202-e1210. Epub 2018 Nov 14.

Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.

Objective: Although reports regarding the relationship between surgical complications and quality of life (QOL) exist, a general consensus regarding this issue is lacking. The aim of this study was to evaluate QOL after endoscopic transsphenoidal approach.

Methods: We assessed patients with sellar or parasellar lesions that were removed with endoscopic transsphenoidal approach or extended endoscopic transsphenoidal approach between January 2010 and December 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.11.017DOI Listing
February 2019
1 Read

Benefit of Intracystic Bleomycin for Symptomatic Recurrent Rathke Cleft Cyst.

Oper Neurosurg (Hagerstown) 2018 Nov 16. Epub 2018 Nov 16.

School of Medicine, University of Colorado, Aurora, Colorado.

Background: Management of recurrent Rathke cleft cysts (RCC) is problematic. The mainstay of treatment has been reoperation with cyst drainage. Radical cyst resection, although effective, results in a high incidence of diabetes insipidus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ons/opy361DOI Listing
November 2018
2 Reads

A Steerable Endoscope for Transnasal Skull Base Surgery.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:4158-4161

In this paper, we described the development of an endoscopic system with the application of minimally invasive observation for a pituitary tumor or a craniopharyngioma. The end-effector was manufactured by attaching an image sensor to the end of a manipulator with a diameter of 3 mm (smaller than a commercial endoscope) by making slits on a biocompatible PAI (Polyamide-imide) tube. The end-effector having 2 degrees of freedom for bending is designed not only to cover most of the FOVs (92. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/EMBC.2018.8513308DOI Listing
July 2018
1 Read

A case of craniopharyngioma presenting as rapidly progressive dementia.

Indian J Psychiatry 2018 Jul-Sep;60(3):355-357

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Rapidly progressive dementia (RPD) is generally obvious to family member but often difficult for physicians to pinpoint the underlying pathology. Some common causes, such as prion's disease, Alzheimer's disease, central nervous system vasculitis, or infection, might present with disease-specific signs or symptoms where many etiologies do not produce such warning signs. Here, we are presenting a case who attended the psychiatric clinic for decreased motivation to do work, easy fatigability, infrequent falls, recent memory impairment, increased appetite, polydipsia and polyuria, and provisionally diagnosed with RPD. Read More

View Article

Download full-text PDF

Source
http://www.indianjpsychiatry.org/text.asp?2018/60/3/355/2433
Publisher Site
http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_230_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201673PMC
November 2018
8 Reads

Trans-eyebrow supraorbital keyhole approach in suprasellar and third ventricular craniopharyngioma surgery: the experience of 27 cases and a literature review.

J Neurooncol 2019 Jan 3;141(2):363-371. Epub 2018 Nov 3.

Department of Neurosurgery, Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China.

Background: The trans-eyebrow supraorbital keyhole approach, a minimal transcranial approach, has been widely used in different types of surgery for sellar and parasellar lesions. In this study, we investigated the outcome of this approach in the surgical treatment of suprasellar and third ventricular craniopharyngioma.

Methods: Twenty-seven patients with suprasellar and third ventricular craniopharyngioma underwent surgery via a supraorbital approach between June 2007 and June 2018. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11060-018-03041-7
Publisher Site
http://dx.doi.org/10.1007/s11060-018-03041-7DOI Listing
January 2019
18 Reads

Extracellular multivesicular bodies in tissues affected by inflammation/repair and tumors.

Ultrastruct Pathol 2018 Sep-Oct;42(5):448-457

a Department of Basic Medical Sciences (Anatomy, Pathology and Histology) , University of La Laguna , Tenerife , Spain.

Extracellular vesicles (EVs) are a heterogeneous population involved in intercellular communication. Little attention has been paid to a peculiar EV type with the appearance of a multivesicular body: extracellular multivesicular body (EMVB), also termed matrix vesicle cluster/multivesicular cargo. The aim of this work is to assess the ultrastructural characteristics, participation, and tissue location of EMVBs in inflammation/repair and tumors (with physiopathological processes involving intense intercellular communication), for which representative specimens were used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01913123.2018.1534915DOI Listing
December 2018
3 Reads