5,893 results match your criteria Craniopharyngioma

Transcortical endoscopic removal of residual craniopharyngioma in the third ventricle: surgical video.

World Neurosurg 2022 May 11. Epub 2022 May 11.

Department of Neurosurgery(,) Tohoku University Graduate School of Medicine, Sendai, Japan.

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Giant Pediatric Supratentorial Tumor: Clinical Feature and Surgical Strategy.

Front Pediatr 2022 26;10:870951. Epub 2022 Apr 26.

Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: To analyze the clinical character of giant pediatric supratentorial tumor (GPST) and explore prognostic factors.

Materials And Methods: We analyzed the clinical data comprising of 35 cases of GPST from a single center between January 2015 and December 2020. The tumor volume was measured by 3D slicer software based on preoperative magnetic resonance imaging (MRI). Read More

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Limited Surgery and Conformal Photon Radiation Therapy for Pediatric Craniopharyngioma: Long-term Results from the RT1 Protocol.

Neuro Oncol 2022 May 12. Epub 2022 May 12.

Departments of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Background: Our aim was to estimate long-term disease control and complications after conformal radiation therapy (CRT) in children and adolescents with craniopharyngioma.

Materials And Methods: Pediatric patients with craniopharyngioma (n=101) were enrolled on or treated according to a phase II single institutional protocol from 1998. Surgery was individualized, and CRT (54Gy) was administered using a 1. Read More

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Epidemiological characteristics of central nervous system tumors in children: a 5-year review of 3180 cases from Beijing Tiantan Hospital.

Chin Neurosurg J 2022 May 12;8(1):11. Epub 2022 May 12.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: To describe the epidemiological characteristics of central nervous system (CNS) tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital.

Methods: From January 2015 to December 2019, 3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization (WHO) classification of tumors. Patients were 0 to 15 years old. Read More

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Long-Term Outcomes of Paediatric-Onset Craniopharyngioma: A Retrospective Analysis from a Tertiary Care Centre in North India.

Neurol India 2022 Mar-Apr;70(2):600-605

Department of Endocrinology (Pediatric), Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Craniopharyngiomas are associated with long-term morbidity in the form of hormone deficiencies, visual deficits, and hypothalamic obesity.

Objective: To study the long-term outcomes, including cure rates, endocrine dysfunction, visual dysfunction, hypothalamic obesity, and mortality in pediatric-onset craniopharyngiomas.

Methods: A retrospective data analysis of pediatric (onset <18 years) craniopharyngioma diagnosed between 2003 and 2018. Read More

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Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloid.

J Neuroinflammation 2022 May 7;19(1):108. Epub 2022 May 7.

Department of Neurosurgery, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou North Road, Guangzhou, Guangdong, China.

Introduction: The mechanism by which adamantinomatous craniopharyngioma (ACP) damages the hypothalamus is still unclear. Cyst fluid rich in lipids and inflammatory factors is a characteristic pathological manifestation of ACP and may play a very important role in hypothalamic injury caused by tumors.

Objective: The objective of this study was to construct a reliable animal model of ACP cyst fluid-induced hypothalamic injury and explore the specific mechanism of hypothalamic injury caused by cyst fluid. Read More

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Five-Year Changes in Weight and Diabetes Status After Bariatric Surgery for Craniopharyngioma-Related Hypothalamic Obesity: a Case-Control Study.

Obes Surg 2022 May 6. Epub 2022 May 6.

Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris, Service de Nutrition, Hôpital Européen Georges Pompidou, Centre Spécialisé Obésité Ile-de-France Sud, 75015, Paris, France.

Purpose: Craniopharyngiomas are tumors located in the hypothalamic region which leads to obesity in about 50% of cases. Long-term efficacy and safety of bariatric surgery are lacking in this peculiar population. The aim of this study is to determine the 5-year weight loss and resolution of type 2 diabetes (T2D) after bariatric surgery in patients operated on craniopharyngioma who had developed hypothalamic obesity. Read More

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Surgical resection of giant extrasellar thyrotropinoma: Use of orbitozygomatic and endoscopic endonasal approach.

Surg Neurol Int 2022 31;13:119. Epub 2022 Mar 31.

Department of Neurosurgery, Centre for Skull Base and Pituitary Neurosurgery, Bristol Institute of Clinical Neuroscience, Southmead Hospital, Bristol, United Kingdom.

Background: Thyrotropinomas (TSHoma) are rare pituitary adenomas.

Case Description: A 34-year-old female presented with mild bitemporal field defect in third trimester with intact pituitary function. MRI demonstrated an enhancing lesion from the posterior planum to suprasellar, interpeduncular and prepontine cisterns with chiasmal compression and right fetal posterior communicating artery encasement. Read More

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Primary collision tumors of the sellar region: Experience from a single center.

J Clin Neurosci 2022 Jun 28;100:204-211. Epub 2022 Apr 28.

Department of Pathology, Tangdu Hospital, Air Force Medical University, Xi'an, PR China. Electronic address:

Collision tumors are extremely rare in the sellar region, and their features have not been fully characterized. Here, we report our single-center experience in the diagnosis and management of these tumors, focusing primarily on their clinicopathological features. We first performed a retrospective study of pathological reports from patients who had undergone surgery for pituitary adenoma (PA) or craniopharyngioma (CP) at our hospital. Read More

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Outcomes of endoscopic endonasal resection of pediatric craniopharyngiomas.

Int Forum Allergy Rhinol 2022 Apr 29. Epub 2022 Apr 29.

Department of Otorhinolaryngology - Head & Neck Surgery, University of Pennsylvania Health System, Pennsylvania, USA.

Background: Craniopharyngiomas have traditionally been treated via open transcranial approaches. More recently, endoscopic endonasal approaches have been increasingly used; however, there has been limited evaluation of long-term outcomes for this approach.

Methods: A retrospective review was performed to analyze pediatric craniopharyngioma patients undergoing endonasal endoscopic resection from 2012-2020. Read More

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Endocrine Outcomes after Limited Surgery and Conformal Photon Radiation Therapy for Pediatric Craniopharyngioma: Long-term Results from the RT1 Protocol.

Neuro Oncol 2022 Apr 27. Epub 2022 Apr 27.

Department of Pediatrics, University of California, San Francisco, CA, USA.

Background: To estimate the incidence of endocrinopathy in children and adolescents with craniopharyngioma after treatment with photon-based conformal and intensity-modulated radiation therapy (CRT).

Methods: 101 pediatric patients were enrolled on a phase II single-institution protocol beginning in 1998 (n=76) or followed a similar non-protocol treatment plan (n=25). Surgery was individualized. Read More

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Basal Recess in Third Ventricle Tumors: A Pathological Feature Defining a Clinical-Topographical Subpopulation of Papillary Craniopharyngiomas.

J Neuropathol Exp Neurol 2022 Apr 26. Epub 2022 Apr 26.

Statistics Department, Computing Center, C.S.I.C. Madrid, Spain.

This study investigates the presence of a hollow recess at the midline undersurface of tumors primarily localized within the third ventricle (3V). This structure was originally identified by magnetic resonance imaging (MRI) of 6 3V craniopharyngiomas (CPs) from our series and was then methodically scrutinized in autopsy studies (n = 1091) and MRI scans (n = 5558) of CPs and in 1251 3V tumors reported in the medical literature from 1839 to 2021. A recess at the tumor base was identified in 110 CPs, 95 with a verified papillary histology (papillary craniopharyngioma [PCP]) and 15 with typical gross appearance of PCP. Read More

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Targeted Therapy in the Management of Modern Craniopharyngiomas.

Front Biosci (Landmark Ed) 2022 Apr;27(4):136

Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132, USA.

Background: The proximity of craniopharyngiomas (CPs) to critical neurovascular structures can lead to a host of neurologic and endocrine complications that lead to difficulty with surgical management. In this review, we examine the molecular and genetic markers implicated in CP, their involvement in tumorigenic pathways, and their impact on CP prognosis and treatment.

Methods: We undertook a focused review of relevant articles, clinical trials, and molecular summaries regarding CP. Read More

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Treatment of Acquired Hypothalamic Obesity: Now and the Future.

Paul Dimitri

Front Endocrinol (Lausanne) 2022 6;13:846880. Epub 2022 Apr 6.

The Department of Paediatric Endocrinology, Sheffield Children's NHS Foundation Trust, Sheffield, United Kingdom.

The hypothalamus is the centre of neuroendocrine regulation of energy homeostasis and appetite. Maldevelopment of, or damage to, the key hypothalamic nuclei disrupts the coordinated balance between energy intake and expenditure leading, to rapid and excessive weight gain. Hypothalamic obesity is compounded by a disruption of the hypothalamic-pituitary axis, sleep disruption, visual compromise, and neurological and vascular sequalae. Read More

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Hypothalamic syndrome.

Nat Rev Dis Primers 2022 Apr 21;8(1):24. Epub 2022 Apr 21.

Department of Paediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, Netherlands.

Hypothalamic syndrome (HS) is a rare disorder caused by disease-related and/or treatment-related injury to the hypothalamus, most commonly associated with rare, non-cancerous parasellar masses, such as craniopharyngiomas, germ cell tumours, gliomas, cysts of Rathke's pouch and Langerhans cell histiocytosis, as well as with genetic neurodevelopmental syndromes, such as Prader-Willi syndrome and septo-optic dysplasia. HS is characterized by intractable weight gain associated with severe morbid obesity, multiple endocrine abnormalities and memory impairment, attention deficit and reduced impulse control as well as increased risk of cardiovascular and metabolic disorders. Currently, there is no cure for this condition but treatments for general obesity are often used in patients with HS, including surgery, medication and counselling. Read More

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Integrative Analysis of Biomarkers and Mechanisms in Adamantinomatous Craniopharyngioma.

Front Genet 2022 30;13:830793. Epub 2022 Mar 30.

Department of Neurosurgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Craniopharyngioma is a benign tumor, and the predominant treatment methods are surgical resection and radiotherapy. However, both treatments may lead to complex complications, seriously affecting patients' survival rate and quality of life. Adamantinomatous craniopharyngioma (ACP), as one of the histological subtypes of craniopharyngioma, is associated with a high incidence and poor prognosis, and there is a gap in the targeted therapy of immune-related genes for ACP. Read More

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Body mass index at diagnosis of a childhood brain tumor; a reflection of hypothalamic-pituitary dysfunction or lifestyle?

Support Care Cancer 2022 Apr 13. Epub 2022 Apr 13.

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

Purpose: Childhood brain tumor survivors (CBTS) are at risk of becoming overweight, which has been shown to be associated with hypothalamic-pituitary (HP) dysfunction during follow-up. Body mass index (BMI) at diagnosis is related to BMI at follow-up. It is uncertain, however, whether aberrant BMI at brain tumor diagnosis reflects early hypothalamic dysfunction or rather reflects genetic and sociodemographic characteristics. Read More

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Ghost cells unveiled: A comprehensive review.

J Oral Biosci 2022 Apr 6. Epub 2022 Apr 6.

Head of Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi 110002, India. Electronic address:

Background: Ghost cells (GCs) are cells with distinct intracytoplasmic keratinization, which leads to the preservation of the cellular outline with a clear area corresponding to the previous nucleus location. GCs may show various patterns, such as degeneration, tissue granulation, and calcification. Their true nature and the mechanism regulating the conversion of odontogenic epithelial cells into GCs remain unclear. Read More

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Craniopharyngioma and the Third Ventricle: This Inescapable Topographical Relationship.

Front Oncol 2022 22;12:872689. Epub 2022 Mar 22.

Department of Neurosurgery, Puerta de Hierro University Hospital, Madrid, Spain.

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Xanthogranulomatous colloid cyst in a 13-year-old boy - A case report and surgical implications.

Pediatr Neurosurg 2022 Apr 5. Epub 2022 Apr 5.

Introduction Colloid cysts are relatively uncommon lesions in the pediatric population. The xanthogranulomatous (XG) variant is a very rare with less than 30 reported cases. Case Report In this report the patient was a 13-year-old boy who presented with transient epsiodes of headache with blurring of vision. Read More

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Management of Internal Carotid Artery Injury During Transsphenoidal Surgery: A Case Series and Suggestion for Optimal Management.

World Neurosurg 2022 Mar 30. Epub 2022 Mar 30.

Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Objective: Internal carotid artery (ICA) injury during transsphenoidal surgery is a rare but serious complication. We analyzed a series of ICA injuries that occurred during a transsphenoidal approach to suggest an optimal management strategy.

Methods: Between January 2015 and May 2020, we enrolled 10 cases of ICA injury at our institution. Read More

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Clinical Features of Craniopharyngioma With Tumoral Hemorrhage: A Retrospective Case-Controlled Study.

Front Surg 2022 14;9:845273. Epub 2022 Mar 14.

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Craniopharyngioma (CP) with tumoral hemorrhage is a very rare syndrome presenting with various manifestation and unfavorable outcomes. The current retrospective study was performed to summarize the clinical features of CP with tumoral hemorrhage.

Methods: In this study, 185 patients with pathological diagnosis of CP (18 patients with hemorrhage) were enrolled. Read More

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[Pituicytoma: a clinicopathological analysis of twenty-one cases].

Zhonghua Bing Li Xue Za Zhi 2022 Apr;51(4):314-318

Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the clinicopathological features and treatment strategies of pituicytoma. Twenty-one cases of pituicytoma were collected at the First Affiliated Hospital of Nanjing Medical University and Jinling Hospital, Nanjing, China from 2009 to 2020. The clinical data of 21 pituicytoma patients was retrospectively analyzed, and the relevant literature was reviewed. Read More

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Craniopharyngioma and Metabolic Syndrome: A 5-Year Follow-Up Single-Center Experience.

Front Neurol 2022 9;13:783737. Epub 2022 Mar 9.

Endocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Patients with craniopharyngioma often have comorbidities, such as obesity and hypopituitarism. These two conditions affect each other and worsen the quality of life of patients, which lead to a higher risk of morbidity and mortality. In addition, abdominal obesity, measured as waist circumference (WC), is together with other parameters [arterial hypertension, hyperglycemia, hypertriglyceridemia, and reduced levels of high-density lipoprotein (HDL) cholesterol], one of the components of metabolic syndrome (MS). Read More

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Dextroamphetamine Treatment in Children With Hypothalamic Obesity.

Front Endocrinol (Lausanne) 2022 9;13:845937. Epub 2022 Mar 9.

Division of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.

Introduction: Hypothalamic obesity (HO) in children has severe health consequences. Lifestyle interventions are mostly insufficient and currently no drug treatment is approved for children with HO. Amphetamines are known for their stimulant side-effect on resting energy expenditure (REE) and suppressing of appetite. Read More

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Parafoveal and peripapillary vessel density in pediatric and juvenile craniopharyngioma patients.

Sci Rep 2022 03 30;12(1):5355. Epub 2022 Mar 30.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

We assessed the retinal microvascular alterations detected by optical coherence tomography angiography (OCT-A) in pediatric and juvenile craniopharyngioma (CP) patients with chiasmal compression. We included 15 eyes of 15 pediatric or juvenile CP patients and 18 eyes of 18 healthy subjects. The evaluation of vessel density from the superficial retinal capillary plexus (SRCP), the deep retinal capillary plexus, and the radial peripapillary capillary (RPC) segments was obtained by OCT-A. Read More

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Current Advances in the Management of Adult Craniopharyngiomas.

Curr Oncol 2022 03 4;29(3):1645-1671. Epub 2022 Mar 4.

Department of Neurosurgery, College of Medicine, University of Florida, 653 8th St W., Jacksonville, FL 32209, USA.

Craniopharyngiomas (CPs) are slow growing, histologically benign intracranial tumors located in the sellar-suprasellar region. Although known to have low mortality, their location and relationship to the adjacent neural structures results in patients having significant neurologic, endocrine, and visual comorbidities. The invasive nature of this tumor makes complete resection a challenge and contributes to its recurrence. Read More

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The Role of Surgical Approaches in the Multi-Modal Management of Adult Craniopharyngiomas.

Curr Oncol 2022 02 24;29(3):1408-1421. Epub 2022 Feb 24.

Department of Neurosurgery, Yale School of Medicine, New Haven, CT 06510, USA.

Craniopharyngiomas are rare, benign primary brain tumors that arise from remnants of the craniopharyngeal duct epithelium within the sellar and suprasellar region. Despite their benign biology, they may cause significant morbidity, secondary to involvement of nearby eloquent neural structures, such as the pituitary gland, hypothalamus, and optic apparatus. Historically, aggressive surgical resection was the treatment goal to minimize risk of tumor recurrence via open transcranial midline, anterolateral, and lateral approaches, but could lead to clinical sequela of visual, endocrine, and hypothalamic dysfunction. Read More

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February 2022

A Comparison of Long-Term Treatment Outcomes Between Giant and Nongiant Craniopharyngiomas.

World Neurosurg 2022 Mar 20. Epub 2022 Mar 20.

Department of Neurological Sciences, Christian Medical College, Vellore, India.

Background: There is limited literature on outcomes after surgical treatment of giant craniopharyngiomas in adult and pediatric patients.

Methods: A retrospective review of 159 patients undergoing surgery for craniopharyngiomas at a single institution was performed. Patients with giant craniopharyngiomas (maximum dimension ≥4. Read More

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Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement.

Eur J Endocrinol 2022 Apr 21;186(6):P35-P52. Epub 2022 Apr 21.

Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.

Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been studied extensively. Experimental studies showing the permissive role of GH/insulin-like growth factor 1 (IGF-I) in carcinogenesis have raised concerns regarding the safety of GH replacement in children and adults who have received treatment for cancer and those with intracranial and pituitary tumours. A consensus statement was produced to guide decision-making on GH replacement in children and adult survivors of cancer, in those treated for intracranial and pituitary tumours and in patients with increased cancer risk. Read More

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