25,663 results match your criteria Coxsackieviruses


Transcriptomic analysis reveals that enterovirus F strain SWUN-AB001 infection activates JNK/SAPK and p38 MAPK signaling pathways in MDBK cells.

BMC Vet Res 2018 Dec 13;14(1):395. Epub 2018 Dec 13.

College of Life Science and Technology, Southwest Minzu University, No.16, South 4th Section 1st Ring Road, Chengdu, 610041, China.

Background: Enteroviruses (Picornaviridae family) have been widely detected in the feces from cattle with diarrhea. However, the mechanisms responsible for the pathogenicity of enteroviruses in cattle remain unclear. Recently, we isolated a novel EV-F7 strain called SWUN-AB001 from diarrheal yak (Bos grunniens) feces. Read More

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December 2018

Parechovirus A Detection by a Comprehensive Approach in a Clinical Laboratory.

Viruses 2018 Dec 12;10(12). Epub 2018 Dec 12.

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.

Parechovirus A (Human parechovirus, HPeV) causes symptoms ranging from severe neonatal infection to mild gastrointestinal and respiratory disease. Use of molecular approaches with RT-PCR and genotyping has improved the detection rate of HPeV. Conventional methods, such as viral culture and immunofluorescence assay, together with molecular methods facilitate comprehensive viral diagnosis. Read More

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December 2018
1 Read

Population based hospitalization burden of laboratory-confirmed hand, foot and mouth disease caused by multiple enterovirus serotypes in Southern China.

PLoS One 2018 13;13(12):e0203792. Epub 2018 Dec 13.

Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: Hand, foot and mouth disease (HFMD) is spread widely across Asia, and the hospitalization burden is currently not well understood. Here, we estimated serotype-specific and age-specific hospitalization rates of HFMD in Southern China.

Methods: We enrolled pediatric HFMD patients admitted to 3/3 county-level hospitals, and 3/23 township-level hospitals in Anhua county, Hunan (CN). Read More

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December 2018

Screening and Identification of Linear B Cell Epitopes Within the Nonstructural Proteins of Enterovirus 71.

Viral Immunol 2018 Dec 6. Epub 2018 Dec 6.

Department of Laboratory Medicine, School of Medicine, Shaoxing University , Shaoxing, P.R. China .

Enterovirus 71 (EV-A71) has attracted widespread attention in the past decade because of its higher neurotropicity in addition to causing hand-foot-and-mouth disease (HFMD). Mapping epitopes of viral proteins may promote our understanding of antiviral humoral immunity, and is useful for clinical application. In this study, the linear B cell epitopes within nonstructural proteins of EV-A71 were identified using bioinformatics methods combined with peptide enzyme-linked immunosorbent assay (ELISA). Read More

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December 2018

Molecular epidemiology and clinical features of hand, foot and mouth disease in northern Thailand in 2016: a prospective cohort study.

BMC Infect Dis 2018 Dec 6;18(1):630. Epub 2018 Dec 6.

School of Health Science Research, Mae Fah Luang University, 333 Mo.1 Tasud Subdistrict, Muang District, Chiang Rai, Chiang Rai Province, 57100, Thailand.

Background: Hand, foot and mouth disease (HFMD) is a major communicable disease in children ≤6 years old, particularly in several countries in the Asia-Pacific Region, including Thailand. HFMD impacts public health and the economy, especially in northern Thailand.

Methods: A prospective cohort study was conducted to estimate the incidence rate and to identify the serotype and clinical features of HFMD among children in northern Thailand. Read More

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December 2018

Virus genotyping by massive parallel amplicon sequencing: adenovirus and enterovirus in the Norwegian MIDIA study.

J Med Virol 2018 Dec 10. Epub 2018 Dec 10.

Division of Mental and Physical Health, Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.

Objectives: Direct genotyping of adenovirus or enterovirus from clinical material using polymerase chain reaction (PCR) followed by Sanger sequencing is often difficult due to the presence of multiple virus types in a sample, or due to varying efficacy of PCR amplifying the capsid gene on the background of foreign nucleic acids. Here we present a simple protocol for virus genotyping using massive parallel amplicon sequencing.

Methods: The protocol utilized a set of 16 tailed degenerate primers flanking the seventh hypervariable region of the adenovirus hexon gene and 9 tailed degenerate primers targeted to the proximal portion of the enterovirus VP1 gene. Read More

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December 2018
1 Read

Magnetic resonance imaging in enterovirus-71, myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and multiple sclerosis-associated myelitis in children.

Dev Med Child Neurol 2018 Dec 10. Epub 2018 Dec 10.

Neuroimmunology Group, Institute for Neuroscience and Muscle Research, The Kids Research Institute, Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Aim: We used magnetic resonance imaging (MRI) to compare the neuroimaging of children with their first episode of clinical enterovirus 71-associated transverse myelitis (EV71-TM), myelin oligodendrocyte glycoprotein antibody positive transverse myelitis (MOG-TM), aquaporin-4 antibody positive transverse myelitis (AQP4-TM), transverse myelitis in multiple sclerosis (MS-TM), and unclassified transverse myelitis (UNC-TM).

Method: We performed a retrospective blinded radiological assessment and compared the neuroimaging of 52 children (32 females, 20 males; mean age 9y 8mo, SD 5y 5mo, range 5mo-17y) presenting with their first episode of myelitis caused by EV71-TM (n=11), MOG-TM (n=10), AQP4-TM (n=9), MS-TM (n=13), and UNC-TM (n=9).

Results: In the EV71-TM group, lesions were distributed throughout the cord and enhancement of nerve roots (ventral and dorsal) was common. Read More

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December 2018

[Neonatal viral meningitis. The importance of the polymerase chain reaction in their diagnosis].

Rev Neurol 2018 Dec;67(12):484-490

Hospital General Universitario de Albacete, 02006 Albacete, Espana.

Introduction: The different types of viral meningitis constitute a condition that is relatively frequent in newborn infants, although in many cases they are underdiagnosed due to the absence of pleocytosis in the cerebrospinal fluid (CSF).

Aims: To describe the clinical features and laboratory findings of newborn infants with viral meningitis and to highlight the importance of the polymerase chain reaction (PCR) in the CSF to diagnose this condition.

Patients And Methods: A retrospective review of the medical records of newborn infants hospitalised in the neonatology section who had been diagnosed with viral meningitis between May 2014 and May 2017. Read More

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December 2018

Characterization of the Genome Sequences of Enterovirus C109 from Two Respiratory Disease Cases in Florida, 2016.

Microbiol Resour Announc 2018 Jul 26;7(3). Epub 2018 Jul 26.

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

The genomic sequences of two enterovirus C109 isolates (EV-C109 USA/FL/2016-21003 and EV-C109 USA/FL/2016-21002) were obtained during two separate case investigations of respiratory disease in two children. This marks the first description of EV-C109 genomes in the United States. Read More

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Reference Echovirus 7 and 19 Genomes from Nigeria.

Microbiol Resour Announc 2018 Dec 6;7(22). Epub 2018 Dec 6.

Department of Virology, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria.

We describe the genomes of two echovirus isolates from Nigeria as reference enterovirus species B genomes for the region. These echovirus 7 and 19 genomes have 7,411 nucleotides (nt) and 7,426 nt and were recovered from sewage-contaminated water (in 2010) and an acute flaccid paralysis case (in 2014), respectively. Read More

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December 2018

Infectious and Noninfectious Acute Pericarditis in Children: An 11-Year Experience.

Int J Pediatr 2018 8;2018:5450697. Epub 2018 Nov 8.

Division of Infectious Diseases, Children's Hospital of Michigan, Detroit, MI, USA.

Objective: The study was undertaken to determine the etiology, review management, and outcome in children diagnosed with acute pericarditis during 11 years at tertiary pediatric institution.

Methods: Retrospective chart review of children diagnosed between 2004 and 2014. Patients with postsurgical pericardial effusions were excluded. Read More

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November 2018
1 Read

Genetic diversity of the enteroviruses detected from cerebrospinal fluid (CSF) samples of patients with suspected aseptic meningitis in northern West Bank, Palestine in 2017.

PLoS One 2018 10;13(12):e0202243. Epub 2018 Dec 10.

Rafeedia Medical Laboratory Hospital, Palestinian Ministry of Health, Nablus, Palestine.

Background: Human enterovirus genus showed a wide range of genetic diversity.

Objectives: To investigate the genetic diversity of the enteroviruses isolated in 2017 in northern West Bank, Palestine.

Study Design: 249 CSF samples from aseptic meningitis cases were investigated for HEV using two RT-PCR protocols targeting the 5' NCR and the VP1 region of the HEV genome. Read More

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December 2018

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Nat Microbiol 2018 Dec 10. Epub 2018 Dec 10.

Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell entry. The isolated structures of EV71 and SCARB2 are known, but how they interact to initiate infection is not. Read More

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December 2018

Epidemiology of Meningitis and Encephalitis in Infants and Children in the United States, 2011-2014.

Pediatr Infect Dis J 2019 Jan;38(1):37-41

bioMérieux, Durham, NC.

Background: Large epidemiologic studies evaluating the etiologies, management decisions and outcomes of infants and children with meningitis and encephalitis in the United States are lacking.

Methods: Children 0-17 years of age with meningitis or encephalitis as assessed by International Classification of Diseases, Ninth Revision, codes available in the Premier Healthcare Database during 2011-2014 were analyzed.

Results: Six thousand six hundred sixty-five patients with meningitis or encephalitis were identified; 3030 (45. Read More

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January 2019

Molecular basis for the acid-initiated uncoating of human enterovirus D68.

Proc Natl Acad Sci U S A 2018 Dec 10. Epub 2018 Dec 10.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907;

Enterovirus D68 (EV-D68) belongs to a group of enteroviruses that contain a single positive-sense RNA genome surrounded by an icosahedral capsid. Like common cold viruses, EV-D68 mainly causes respiratory infections and is acid-labile. The molecular mechanism by which the acid-sensitive EV-D68 virions uncoat and deliver their genome into a host cell is unknown. Read More

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December 2018

Enterovirus and parechovirus meningitis in infants younger than 90 days old in the UK and Republic of Ireland: a British Paediatric Surveillance Unit study.

Arch Dis Child 2018 Dec 8. Epub 2018 Dec 8.

Paediatric Infectious Diseases Research Group, St George's University of London, London, UK.

Objectives: This study aimed to prospectively collect detailed clinical information for all enterovirus (EV) and human parechovirus (HPeV) meningitis cases in infants aged <90 days in the UK and Ireland.

Participants, Design And Setting: Prospective, active national surveillance during July 2014 to July 2015 through the British Paediatric Surveillance Unit. Reporting paediatricians completed questionnaires requesting information on clinical presentation, investigations, management and outcomes at hospital discharge and after 12 months. Read More

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December 2018

Surveillance of enteroviruses from paediatric patients attended at a tertiary hospital in Catalonia from 2014 to 2017.

J Clin Virol 2018 Nov 30;110:29-35. Epub 2018 Nov 30.

Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Enterovirus (EV) infections are usually asymptomatic or mild, but symptomatic infections can evolve to severe complications. Outbreaks of EV-A71 and EV-D68 have been recently reported worldwide, sometimes related to severe clinical outcomes.

Objective: To describe EV genetic diversity and the clinical outcomes from paediatric patients attended at a tertiary university hospital in Barcelona (Catalonia, Spain) from 2014 to 2017. Read More

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November 2018

Hepatitis E virus is not detected in association with neurological disorders among Brazilian children.

Microbes Infect 2018 Dec 6. Epub 2018 Dec 6.

Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Niterói, RJ, Brazil. Electronic address:

Hepatitis E virus is increasingly being associated with idiopathic neurological disease. We tested 325 stool samples from Brazilian children presenting acute flaccid paralysis or Guillain-Barré syndrome using a broadly reactive and sensitive Reverse-transcription Polymerase chain reaction. Hepatitis E genome was not detected in any of the samples tested. Read More

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December 2018

Development of a respiratory disease model for enterovirus D68 in 4-week-Old mice for evaluation of antiviral therapies.

Antiviral Res 2018 Dec 3. Epub 2018 Dec 3.

Institute for Antiviral Research, Utah State University, Logan, UT, United States; Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, United States; Utah Veterinary Diagnostic Laboratory, Logan, UT, United States. Electronic address:

Enterovirus D68 (EV-D68) is a non-polio enterovirus that affects the respiratory system and can cause serious complications, especially in children and older people with weakened immune systems. As an emerging virus, there are no current antiviral therapies or vaccines available. Our goal was to develop a mouse model of human EV-D68 infection that mimicked the disease observed in humans and could be used for evaluation of experimental therapeutics. Read More

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December 2018
8 Reads

Urine Catecholamines in Children with Severe Enterovirus A71 infection: Comparison with Paediatric Septic Shock.

Biomarkers 2018 Dec 6:1-15. Epub 2018 Dec 6.

a Children's Medical Center , Taichung Veterans General Hospital , Taichung , Taiwan.

Purpose: Hypercatecholaminemia-related heart failure has been proposed as the main cause of enterovirus A71-related (EV-A71) early mortality. The purpose of this study was to measure urine catecholamine concentrations in severe EV-A71-infected children.

Methods: A total of 35 children, aged 2. Read More

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December 2018

Severity of enterovirus A71 infection in a human SCARB2 knock-in mouse model is dependent on infectious strain and route.

Emerg Microbes Infect 2018 Dec 5;7(1):205. Epub 2018 Dec 5.

Department of Medical Microbiology, Capital Medical University, Beijing, 100069, China.

Enterovirus A71 (EV-A71) is a major etiological agent of human hand, foot and mouth disease, and it can cause severe neurological complications. Although several genotypes of EV-A71 strains are prevalent in different regions of the world, the genotype C4 has circulated in mainland China for more than 20 years. The pathogenicity of different EV-A71 clinical isolates varies and needs to be explored. Read More

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December 2018
8 Reads

Epidemiological features and spatial clusters of hand, foot, and mouth disease in Qinghai Province, China, 2009-2015.

BMC Infect Dis 2018 Dec 5;18(1):624. Epub 2018 Dec 5.

Institute for Infectious Disease Control and Prevention, Qinghai Provincial Center for Disease Control and Prevention, Xining, Qinghai, China.

Background: Hand, Foot, and Mouth Disease (HFMD) is most frequently caused by Enterovirus71 (EV-A71) or Coxsackie virus A16 (CV-A16), infants and young children are at greatest risk. Describing the epidemiology of HFMD can help develop and better target interventions, including the use of pediatric EV-A71 vaccination.

Methods: We obtained data from the national surveillance system for HFMD cases with onset dates from 2009 to 2015. Read More

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December 2018
6 Reads

Bioaerosol Sampling for Respiratory Viruses in Singapore's Mass Rapid Transit Network.

Sci Rep 2018 Nov 30;8(1):17476. Epub 2018 Nov 30.

Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore.

As a leading global city with a high population density, Singapore is at risk for the introduction of novel biological threats. This risk has been recently reinforced by human epidemics in Singapore of SARS coronavirus, 2009 pandemic H1N1 influenza A virus, and enterovirus 71. Other major threats to Singapore include MERS-coronavirus and various avian and swine influenza viruses. Read More

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November 2018
1 Read

Small Animal Models of Respiratory Viral Infection Related to Asthma.

Viruses 2018 Dec 1;10(12). Epub 2018 Dec 1.

Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Respiratory viral infections are strongly associated with asthma exacerbations. Rhinovirus is most frequently-detected pathogen; followed by respiratory syncytial virus; metapneumovirus; parainfluenza virus; enterovirus and coronavirus. In addition; viral infection; in combination with genetics; allergen exposure; microbiome and other pathogens; may play a role in asthma development. Read More

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December 2018
1 Read

Neonatal acute liver failure due to enteroviruses: a 14 years single NICU experience.

J Matern Fetal Neonatal Med 2018 Dec 4:1-171. Epub 2018 Dec 4.

a Department of Neonatology , Bambino Gesù Children's Hospital - IRCCS , Rome , Italy.

Background: Neonatal acute liver failure (ALF) is a severe condition with a mortality rate up to 70%. Human enterovirus (HEV) infections are associated with serious diseases in newborns, including myocarditis, meningoencephalitis and, more rarely, ALF with a fulminant course.

Methods: Cases of neonatal-onset ALF were identified using the institutional clinical database. Read More

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December 2018
4 Reads

Enterovirus and Parechovirus infections in children: differences in clinical presentation, mechanisms for meningitis without pleocytosis and mechanisms involved in the neurological outcome.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatrics, Bravis Hospital, Roosendaal, The Netherlands -

Enterovirus (EV) and Parechovirus (HPeV) are a frequent cause of infection in children. This review gives an overview of possible causes for differences in clinical presentation. EV and HPeV can cause a meningitis with or without pleocytosis. Read More

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December 2018
4 Reads

Etiology of Coinfections in Children with Influenza during 2015/16 Winter Season in Nepal.

Int J Microbiol 2018 28;2018:8945142. Epub 2018 Oct 28.

Central Department of Microbiology, Tribhuvan University, Kirtipur, Nepal.

Acute respiratory infections (ARIs) are one of the major public health problems in developing countries like Nepal. Besides the influenza, several other pathogens are responsible for acute respiratory infection in children. Etiology of infections is poorly characterized at the course of clinical management, and hence empirical antimicrobial agents are used. Read More

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October 2018
4 Reads

Pathologic and molecular studies of enterovirus 71 infection in a fatal case from a recent epidemic in China: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13447

Zhejiang Key Laboratory of Pathophysiology, Department of Pathology and Pathogen Biology, Medical School of Ningbo University.

Rationale: Enterovirus 71 (EV71) is identified as the primary cause of hand, foot, and mouth disease (HFMD) and mainly infects the young infants. Though some fatal cases have been reported, the underlying mechanisms of EV71 infection remain elusive and more further pathologic and molecular studies of EV71 infection are needed.

Patient Concerns: A 26-month-old girl with a history of fever and lethargy for 3 days and intermittent seizures for 2 hours associated with rash on 4 limbs was brought to a hospital. Read More

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November 2018
4 Reads

A neonatal mouse model of Enterovirus D68 infection induces both interstitial pneumonia and acute flaccid myelitis.

Antiviral Res 2018 Nov 29;161:108-115. Epub 2018 Nov 29.

National Institute for Food and Drug Control, Beijing, China. Electronic address:

Enterovirus D68 (EV-D68) is a causative agent of recent outbreaks of severe respiratory illness, pneumonia and acute flaccid myelitis (AFM) worldwide. The study of the pathogenesis, vaccines and anti-viral drugs for EV-D68 infection has been reported. Given the previously described mouse model of EV-D68, we sought to establish a neonatal mice model inducing both pneumonia and AFM. Read More

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November 2018

Synthesis and evaluation of steroidal thiazoline conjugates as potential antiviral agents.

Future Med Chem 2018 Nov 30. Epub 2018 Nov 30.

Key Laboratory of Fermentation Engineering (Ministry of Education), Institute of Biomedical & Pharmaceutical Sciences, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, National '111' Center for Cellular Regulation & Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, PR China.

Aim: Many heterocyclic compounds derived from natural steroids exhibited broad activities, so this work focused on the investigations on a series of steroidal thiazoline conjugates as antiviral agents.

Materials & Methods:  A series of steroid derivatives containing thiazoline heterocycles were designed and synthesized via a convenient condensation procedure. The compounds were screened for their potential antivirus activities against Enterovirus 71 (EV71) and Coxsackie Virus Type B (CVB3). Read More

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November 2018
3 Reads

Transcriptomic analysis of cells in response to EV71 infection and 2A as a trigger for apoptosis via TXNIP gene.

Genes Genomics 2018 Nov 29. Epub 2018 Nov 29.

National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Sino-German Biomedical Center, Hubei University of Technology, 430068, Wuhan, China.

Background: Enterovirus 71 (EV71) is the main pathogen of hand-foot-mouth disease (HFMD) and sometimes causes several neurological complications. However, the underlying mechanism of the host response to the virus infection remains unclear.

Objective: To reveal the cell-specific transcriptional response of cultured RD cells following infection with EV71, and better understand the molecular mechanisms of virus-host interactions. Read More

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November 2018
0.596 Impact Factor

Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy.

Viruses 2018 Nov 28;10(12). Epub 2018 Nov 28.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.

Enterovirus 71 (EV71) is a global health threat. Children infected with EV71 could develop hand-foot-and-mouth disease (HFMD), encephalitis, paralysis, pulmonary edema, and death. At present, no effective treatment for EV71 is available. Read More

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November 2018
1 Read

Predicting Intraserotypic Recombination in Enterovirus 71.

J Virol 2018 Nov 28. Epub 2018 Nov 28.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 201 Althouse laboratory, University Park, PA 16802.

Enteroviruses are well known for their ability to cause neurological damage and paralysis. The model enterovirus is poliovirus (PV), the causative agent of poliomyelitis, a condition characterized by acute flaccid paralysis. A related virus, enterovirus 71 (EV-A71), causes similar clinical outcomes in recurrent outbreaks throughout Asia. Read More

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November 2018

Echovirus 30 and coxsackievirus A9 infection among young neonates with sepsis in Iran.

Iran J Microbiol 2018 Aug;10(4):258-265

Biostatistic Department, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background And Objectives: Human enteroviruses (EV) are the most common causes of neonatal sepsis-like disease. The frequencies of EV including coxsackievirus A, coxsackievirus B and Echovirus serotypes have been studied in young infants (younger than three months) with sepsis. So far, the role of enteroviruses among neonates with sepsis was not determined in Ahvaz, Iran. Read More

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August 2018
1 Read

Enterovirus D68 - The New Polio?

Front Microbiol 2018 13;9:2677. Epub 2018 Nov 13.

Department of Medical Microbiology and Infection Prevention, Division of Clinical Virology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Enterovirus D68 (EV-D68) has emerged over the recent years, with large outbreaks worldwide. Increased occurrence has coincided with improved clinical awareness and surveillance of non-polio enteroviruses. Studies showing its neurotropic nature and the change in pathogenicity have established EV-D68 as a probable cause of Acute Flaccid Myelitis (AFM). Read More

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November 2018
2 Reads

Genetic characterization and molecular epidemiological analysis of novel enterovirus EV-B80 in China.

Emerg Microbes Infect 2018 Nov 28;7(1):193. Epub 2018 Nov 28.

WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. Read More

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November 2018
1 Read

Poliomyelitis.

Handb Clin Neurol 2018 ;159:337-344

Neuroscience Research Australia, Randwick, Sydney, NSW, Australia. Electronic address:

Poliomyelitis, often termed "polio," is an acute infectious disease caused by an enterovirus which damages the anterior horn cells of the spinal cord and brainstem. Progress to lower motor neurone cell death leads to disruption of motor units and subsequent muscle weakness or complete paralysis. Although the virus is mostly eradicated from the Western world, postpolio decline is prevalent among people aged 60 years and over. Read More

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January 2018
3 Reads

An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells.

Nat Microbiol 2018 Nov 26. Epub 2018 Nov 26.

Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

Enteroviruses comprise a large group of mammalian pathogens that includes poliovirus. Pathology in humans ranges from sub-clinical to acute flaccid paralysis, myocarditis and meningitis. Until now, all of the enteroviral proteins were thought to derive from the proteolytic processing of a polyprotein encoded in a single open reading frame. Read More

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November 2018
3 Reads

Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating.

Nat Commun 2018 11 26;9(1):4985. Epub 2018 Nov 26.

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Coxsackievirus A10 (CVA10), a human type-A Enterovirus (HEV-A), can cause diseases ranging from hand-foot-and-mouth disease to polio-myelitis-like disease. CVA10, together with some other HEV-As, utilizing the molecule KREMEN1 as an entry receptor, constitutes a KREMEN1-dependent subgroup within HEV-As. Currently, there is no vaccine or antiviral therapy available for treating diseases caused by CVA10. Read More

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November 2018
3 Reads

[The importance of epidemiological surveillance of emerging enteroviruses].

An Pediatr (Barc) 2018 Nov 23. Epub 2018 Nov 23.

Unidad de Enterovirus y Gastroenteritis Víricas, Laboratorio de Referencia e Investigación en Enfermedades Víricas Inmunoprevenibles, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda (Madrid), España.

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November 2018

The Intertwined Life Cycles of Enterovirus and Autophagy.

Virulence 2018 Nov 26. Epub 2018 Nov 26.

a Center for Heart Lung Innovation, St. Paul' s Hospital and Department of Pathology and Laboratory Medicine , University of British Columbia , Vancouver , BC , V6Z 1Y6 , Canada.

Enteroviruses (EVs) are the most common human pathogens worldwide. Recent international outbreaks in North America and South East Asia have emphasized the need for more effective anti-viral therapies. As obligate parasites, EVs rely on the host cellular machinery for effective viral propagation. Read More

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November 2018
1 Read

Identification of previously untypable RD cell line isolates and detection of EV-A71 genotype C1 in a child with AFP in Nigeria.

Pathog Glob Health 2018 Nov 26:1-7. Epub 2018 Nov 26.

a Department of Virology , College of Medicine, University of Ibadan , Ibadan , Nigeria.

We previously attempted to identify 96 nonpolio enteroviruses (EVs) recovered in RD cell culture from children <15 years with acute flaccid paralysis in Nigeria. We succeeded in identifying 69 of the isolates. Here, we describe an attempt to identify the remaining 27 isolates. Read More

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November 2018
1 Read

Severe atypical hand-foot-and-mouth disease in adults due to coxsackievirus A6: Clinical presentation and phylogenesis of CV-A6 strains.

J Clin Virol 2018 Nov 17;110:1-6. Epub 2018 Nov 17.

Clinical Microbiology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

Background: Typically, hand-foot-and-mouth disease (HFMD) is a mild childhood illness associated with coxsackievirus (CV)-A16, CV-A6, enterovirus (EV)-A71.

Objectives: To identify the viral agents associated with severe cases of atypical HFMD in Italy.

Study Design: Epidemiologically unrelated cases of severe atypical HFMD admitted to the Emergency Room (ER) of IRCCS San Martino IST (Genoa, Italy) in 2014-2016 were investigated. Read More

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November 2018
4 Reads

Progress in human picornavirus research: New findings from the AIROPico consortium.

Antiviral Res 2018 Nov 23;161:100-107. Epub 2018 Nov 23.

HiLIFE -Institute of Biotechnology, and Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.

Several research groups in Europe are active on different aspects of human picornavirus research. The AIROPico (Academia-Industry R&D Opportunities for Picornaviruses) consortium combined the disciplines of pathogenesis, diagnostics and therapy development in order to fill the gaps in our understanding of how picornaviruses cause human disease and how to combat them. AIROPico was the first EU consortium dedicated to human picornavirus research and development, and has largely accelerated and improved R&D on picornavirus biology, diagnostics and therapy. Read More

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November 2018
4 Reads

Induction of immune responses by a novel recombinant fusion protein of enterovirus A71 in BALB/c mice.

Mol Immunol 2018 Nov 19;105:1-8. Epub 2018 Nov 19.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, PR China; College of Life and Environmental Sciences, Wenzhou University, Wenzhou, 325035, PR China; Biomedicine Collaborative Innovation Center, Wenzhou University, Wenzhou, 325035, PR China. Electronic address:

Fusion protein technology is used in biotechnology and medical developments. In this study, recombinant fusion proteins from enterovirus A71 (EV-A71) subgenotype B5, Thailand were designed based two surface proteins (VP1 and VP2) and an internal protein (VP4), and named "VP0" (consisting of VP4-VP2) and "EV71" (consisting of VP4-VP2-VP1), respectively. The recombinant fusion proteins VP0 and EV71 were expressed in insect cells and successfully produced and secreted into the media. Read More

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November 2018
5 Reads
2.970 Impact Factor

Acute Kidney Injury Secondary to Severe Hand, Foot and Mouth Disease Caused by Enterovirus-A71: Hypertension Is a Common.

J Trop Pediatr 2018 Nov 19. Epub 2018 Nov 19.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Hand, foot and mouth disease (HFMD) is a common infectious disease among children, caused primarily by human enterovirus-A71 (EV-A71) and coxsackievirus-A16 (CV-A16). To date, only two case reports mention that renal involvement can be secondary to or coexisting with CV-A16-associated HFMD. In the present report, we describe a 10-year-old girl who was infected with EV-A71 and subsequently developed a definite acute kidney injury (AKI), mainly based on the characteristic rash, virus isolation, eyelid edema, hypertension, decreased urine output, mild proteinuria and impaired renal function. Read More

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November 2018
1 Read

Prospective enterovirus D68 (EV-D68) surveillance from September 2015 to November 2018 indicates a current wave of activity in Wales.

Euro Surveill 2018 Nov;23(46)

Public Health Wales Health Protection Division, Number 2 Capital Quarter, Tyndall Way, Cardiff, Wales, United Kingdom.

Since 7 June 2018, an enterovirus D-68 (EV-D68) season (the third since 2015) is ongoing in Wales, with 114 confirmed cases thus far. Median age of the 220 cases since 2015 is 2.5 years (2. Read More

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November 2018
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Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak.

Euro Surveill 2018 Nov;23(46)

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 was only sporadically detected. The re-emergence of C4 after causing a severe HFMD outbreak with > 200 deaths in 2011-12 among susceptible young children raises concern of another impending severe outbreak. Read More

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November 2018
4 Reads

Relationship between Cell Receptors and Tumor Cell Sensitivity to Oncolytic Enteroviruses.

Bull Exp Biol Med 2018 Nov 18;166(1):58-62. Epub 2018 Nov 18.

V. A. Engelhardt Institute of Molecular Biology, the Russian Academy of Sciences, Moscow, Russia.

Replicative ability of 5 oncolytic enterovirus strains was evaluated on a panel of 18 human normal and tumor cells. The capacity of each cell line to support replication of enterovirus strains varied. Cell lines weakly replicating one virus could be highly sensitive to another viral strain. Read More

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November 2018