Search our Database of Scientific Publications and Authors

I’m looking for a

    25091 results match your criteria Coxsackieviruses

    1 OF 502

    Divergent Pathogenic Properties of Circulating Coxsackievirus A6 Associated with Emerging HFMD.
    J Virol 2018 Mar 21. Epub 2018 Mar 21.
    Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, China
    Coxsackievirus A6 (CV-A6) is an emerging pathogen associated with hand, foot, and mouth disease (HFMD). Its genetic characterization and pathogenic properties are largely unknown. Here, we report 39 circulating CV-A6 strains isolated in 2013 from HFMD patients in Northeast China. Read More

    Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit.
    Cell Rep 2018 Mar;22(12):3304-3314
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 W. Baltimore Avenue, Baltimore, MD 21201, USA. Electronic address:
    Enterovirus D68 (EV-D68) is a medically important respiratory plus-strand RNA virus of children that has been linked to acute flaccid myelitis. We have determined that EV-D68 induces autophagic signaling and membrane formation. Autophagy, a homeostatic degradative process that breaks down protein aggregates and damaged organelles, promotes replication of multiple plus-strand viruses. Read More

    Epidemiological surveillance of hand, foot and mouth disease in Shanghai in 2014-2016, prior to the introduction of the enterovirus 71 vaccine.
    Emerg Microbes Infect 2018 Mar 21;7(1):37. Epub 2018 Mar 21.
    Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
    Hand, foot, and mouth disease (HFMD) is mainly epidemic in China and Southeast Asian countries. A novel enterovirus 71 vaccine has been available in China for preventing severe HFMD since 2016. Knowledge of the dynamic epidemiology of HFMD in different regions is necessary for appropriate intervention strategies. Read More

    Enterovirus Transmission by Secretory Autophagy.
    Viruses 2018 Mar 20;10(3). Epub 2018 Mar 20.
    Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
    Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. Read More

    Evolution of echovirus 11 in a chronically infected immunodeficient patient.
    PLoS Pathog 2018 Mar 19;14(3):e1006943. Epub 2018 Mar 19.
    Central Virology Laboratory, Public Health Service Laboratories Israel Ministry of Health at Sheba Medical Center, Tel Hashomer, Israel.
    Deep sequencing was used to determine complete nucleotide sequences of echovirus 11 (EV11) strains isolated from a chronically infected patient with CVID as well as from cases of acute enterovirus infection. Phylogenetic analysis showed that EV11 strains that circulated in Israel in 1980-90s could be divided into four clades. EV11 strains isolated from a chronically infected individual belonged to one of the four clades and over a period of 4 years accumulated mutations at a relatively constant rate. Read More

    Genetic Characterization of Enterovirus A71 Circulating in Africa.
    Emerg Infect Dis 2018 Apr;24(4):754-757
    We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochthonous EV-A that might contribute to the emergence of pathogenic lineages. Read More

    First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age.
    J Reprod Immunol 2018 Mar 2;127:1-6. Epub 2018 Mar 2.
    Department of Clinical Sciences, Lund University Clinical Research Center, Skåne University Hospital, 205 02 Malmö, Sweden. Electronic address:
    Background: Autoimmune (type 1) diabetes (T1D) is a frequent chronic disease in children and adolescents globally. Gestational enterovirus (EV) infections have been associated with an increased risk for T1D in the offspring. We test the hypothesis that EV infections during the first trimester were associated with beta cell autoantibodies in mothers of children who developed islet autoantibodies before 7 years of age. Read More

    Association of Interleukin-17F gene polymorphisms with susceptibility to severe enterovirus 71 infection in Chinese children.
    Arch Virol 2018 Mar 16. Epub 2018 Mar 16.
    Pediatric Department of the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266000, Shandong, People's Republic of China.
    Enterovirus 71 (EV71) is a single-strand RNA virus that causes hand, foot and mouth disease (HFMD) in infants and young children, leading to neurological complications with significant morbidity and mortality. Unfortunately, the pathogenesis of EV71 infection is not well understood. In this study, we investigated the IL-17F rs1889570 and rs4715290 gene polymorphisms in a Chinese Han population. Read More

    Correction for Cong et al., "Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax".
    J Virol 2018 Apr 14;92(7). Epub 2018 Mar 14.
    Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.

    Detection and genetic characterization of enterovirus strains circulating among children with acute gastroenteritis in Japan during 2014-2016.
    Infect Genet Evol 2018 Mar 11;61:16-19. Epub 2018 Mar 11.
    Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
    Of 972 stool samples collected from infants and children with acute gastroenteritis in six different regions (Hokkaido, Tokyo, Shizuoka, Kyoto, Osaka, and Saga) of Japan during 2-year period from July 2014 to June 2016, 63 samples (6.5%) determined to be positive for enterovirus by multiplex RT-PCR were subjected to genotype determination based on the partial VP1 region using the CODEHOP method. Sixty-two strains were succeeded in genotyping and seventeen EV types were identified. Read More

    A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection.
    J Pediatric Infect Dis Soc 2018 Mar 10. Epub 2018 Mar 10.
    Division of Infectious Diseases, Department of Pediatrics, Pennsylvania.
    Background: Respiratory virus infection (RVI) in pediatric solid organ transplant (SOT) recipients poses a significant risk; however, the epidemiology and effects of an RVI after pediatric SOT in the era of current molecular diagnostic assays are unclear.

    Methods: A retrospective observational cohort of pediatric SOT recipients (January 2010 to June 2013) was assembled from 9 US pediatric transplant centers. Charts were reviewed for RVI events associated with hospitalization within 1 year after the transplant. Read More

    Congenital cytomegalovirus, parvovirus and enterovirus infection in Mozambican newborns at birth: A cross-sectional survey.
    PLoS One 2018 14;13(3):e0194186. Epub 2018 Mar 14.
    Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
    Background: Congenital cytomegalovirus (cCMV) infection is the most prevalent congenital infection acquired worldwide, with higher incidence in developing countries and among HIV-exposed children. Less is known regarding vertical transmission of parvovirus B19 (B19V) and enterovirus (EV). We aimed to assess the prevalence of CMV, B19V and EV vertical transmission and compare results of screening of congenital CMV obtained from two different specimens in a semirural Mozambican maternity. Read More

    Not all that vesicles is herpes.
    Diagnosis (Berl) 2017 Nov;4(4):261-264
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
    Background: Eczema coxsackium (EC) can manifest in patients with underlying atopic dermatitis (AD) as a diffuse vesicular rash in a febrile child. The presentation overlaps clinically with the feared diagnosis of eczema herpeticum (EH), which makes differentiating between the conditions very important.

    Case Presentation: A 6-month-old girl with known AD presented with fever and rapidly spreading vesicular rash. Read More

    Epidemiological Profile of Acute Viral Encephalitis in a Sample of Egyptian Children.
    Open Access Maced J Med Sci 2018 Feb 14;6(2):423-429. Epub 2018 Feb 14.
    Departments of Child Health, National Research Centre, Cairo, Egypt.
    Introduction: Acute encephalitis syndrome (AES) is a considerable public health problem.

    Aim: This study was designed to describe the aetiology, demographic features, clinical picture, short-term outcome and risk factors of mortality of children with viral encephalitis in Egyptian children.

    Methods: PCR detection of viruses in the CSF of pediatric patients admitted to the pediatric unit or ICU Cairo University Pediatric hospital presenting with encephalitis syndrome. Read More

    Neonatal nonpolio enterovirus and parechovirus infections.
    Semin Perinatol 2018 Mar 8. Epub 2018 Mar 8.
    Division of Pediatric Infectious Diseases, Children's National Health System, Washington, DC; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC; Department of Microbiology/Immunology/Tropical Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC.
    Nonpolio enteroviruses and parechoviruses are frequent causes of neonatal infection. Clinical manifestations of infection range from asymptomatic infection to mild infection without sequelae to septic shock with muiltiorgan failure. Neonates with clinically apparent infection typically have mothers and/or other contacts with recent symptoms consistent with a viral illness. Read More

    Factors associated with fatal outcome of children with enterovirus A71 infection: a case series.
    Epidemiol Infect 2018 Mar 12:1-11. Epub 2018 Mar 12.
    Pediatric Emergency Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou,China.
    Enterovirus A-71 (EV-A71) may be fatal, but the natural history, symptoms, and signs are poorly understood. This study aimed to examine the natural history of fatal EV-A71 infection and to identify the symptoms and signs of early warning of deterioration. This was a clinical observational study of fatal cases of EV-A71 infection treated at five Chinese hospitals between 1 January 2010 and 31 December 2012. Read More

    Enteroviruses: Classification, Diseases They Cause, and Approaches to Development of Antiviral Drugs.
    Biochemistry (Mosc) 2017 Dec;82(13):1615-1631
    Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.
    The genus Enterovirus combines a portion of small (+)ssRNA-containing viruses and is divided into 10 species of true enteroviruses and three species of rhinoviruses. These viruses are causative agents of the widest spectrum of severe and deadly epidemic diseases of higher vertebrates, including humans. Their ubiquitous distribution and high pathogenicity motivate active search to counteract enterovirus infections. Read More

    Prokaryotic expression and identification of scavenger receptor B2.
    Acta Virol 2018 ;62(1):50-57
    There is still no effective clinical antiviral drug against human enterovirus 71 (EV71) infection, which causes hand, foot and mouth disease (HFMD) in children. Scavenger receptor class B member 2 (SCARB2) is an important receptor of EV71 as it plays a vital role in the early steps of viral infection. In this study, recombinant SCARB2 protein was expressed and purified in a prokaryotic expression system, and was identified by western blot with a monoclonal antibody and mass spectrometry analysis. Read More

    Complete Genome Sequence of an Enterovirus A71 Strain Isolated in 2006 from a Patient in Shenzhen, Southern China, with a Lethal Case of Enterovirus Infection.
    Genome Announc 2018 Mar 8;6(10). Epub 2018 Mar 8.
    Institute of Pathogen Biology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
    The whole-genome sequence of an enterovirus A71 strain (EV71/SHENZHEN001/2006) isolated in 2006 from a patient with a fatal case of enterovirus infection was determined. Phylogenetic analysis based on the complete VP1 gene classified this strain as subgenotype C4a. Read More

    Enterovirus A71 Proteins: Structure and Function.
    Front Microbiol 2018 21;9:286. Epub 2018 Feb 21.
    Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
    Enterovirus A71 (EV-A71) infection has grown to become a serious threat to global public health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and young children. EV-A71 can also infect the central nervous system (CNS) and induce diverse neurological complications, such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis, or even death. Read More

    [Model of the Complex of the Human Glycyl-tRNA Synthetase Anticodon-Binding Domain with IRES I Fragment].
    Mol Biol (Mosk) 2018 Jan-Feb;52(1):112-119
    Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia.
    The currently available structural information is insufficient for a detailed analysis of interactions between human glycyl-tRNA synthetase (GARS) and enterovirus IRESs. At the same time, this information is required in order to understand how this IRES trans-acting factor (ITAF) functions during viral mRNA translation, which is in turn crucial for the development of direct-action antiviral agents. In this paper, a theoretical model of the complex between a cadicivirus A IRES fragment and the anticodon-binding domain of human GARS is constructed using molecular dynamics simulation based on all of the available structural and biochemical data. Read More

    [Glycyl-tRNA Synthetase as a Potential Universal Regulator of Translation Initiation at IRES-I].
    Mol Biol (Mosk) 2018 Jan-Feb;52(1):10-18
    Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia.
    A full analysis has been conducted of the sequences and secondary structures of viral type-I or related IRESs identified in all of the elements that correspond to the previously described minimal fragment of the enterovirus C IRES, which mimics the glycine tRNA anticodon hairpin in the IRES structure and is necessary for the specific binding of glycyl-tRNA synthetase. Experiments on human glycyl-tRNA synthetase binding with the mRNA fragments of several taxonomically distant viruses showed that the binding constants of these complexes are similar. These results indicate that the regulation of translation initiation via glycyl-tRNA synthetase must be a universal mechanism for these viruses and the corresponding parts of their mRNAs must have similar spatial structures. Read More

    Poliovirus Replicon RNA Generation, Transfection, Packaging, and Quantitation of Replication.
    Curr Protoc Microbiol 2018 Feb 22;48:15H.4.1-15H.4.15. Epub 2018 Feb 22.
    Department of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland.
    Poliovirus is a prototype member of the Enterovirus genus of the Picornaviridae family of small positive strand RNA viruses, which include important human and animal pathogens. Quantitative assessment of viral replication is very important for investigation of the virus biology and the development of anti-viral strategies. The poliovirus genome structure allows replacement of structural genes with a reporter protein, such as a luciferase or a fluorescent protein, whose signals can be detected and quantified in vivo, thus permitting observation of replication kinetics in live cells. Read More

    Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia.
    Sci Rep 2018 Mar 6;8(1):4087. Epub 2018 Mar 6.
    Collaborative and Translation Unit for HFMD, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
    Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A16) and Enterovirus 71 (EV-A71) are considered the main etiological agents. In recent years however, other viruses have also been isolated in considerable numbers from infected individuals in many regions, joining the legion commonly associated with HFMD. Read More

    Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in Children.
    J Infect Dis 2018 Mar 2. Epub 2018 Mar 2.
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryl.
    Background: Live respiratory syncytial virus (RSV) candidate vaccine LIDΔM2-2 is attenuated by deletion of the RSV RNA regulatory protein M2-2, resulting in upregulated viral gene transcription and antigen expression but reduced RNA replication.

    Methods: RSV-seronegative children ages 6-24 months received a single intranasal dose of 105 plaque forming units (PFU) of LIDΔM2-2 (n = 20) or placebo (n = 9) (NCT02237209, NCT02040831). RSV serum antibodies, vaccine infectivity, and reactogenicity were assessed. Read More

    The seasonality of nonpolio enteroviruses in the United States: Patterns and drivers.
    Proc Natl Acad Sci U S A 2018 Mar 5;115(12):3078-3083. Epub 2018 Mar 5.
    Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, United Kingdom.
    Nonpolio enteroviruses are diverse and common viruses that can circulate year-round but tend to peak in summer. Although most infections are asymptomatic, they can result in a wide range of neurological and other diseases. Many serotypes circulate every year, and different serotypes predominate in different years, but the drivers of their geographical and temporal dynamics are not understood. Read More

    Quantification of pathogens and markers of fecal contamination during storm events along popular surfing beaches in San Diego, California.
    Water Res 2018 Jun;136:137-149
    Southern California Coastal Water Research Project, 3535 Harbor Blvd. Ste 110, Costa Mesa, CA 92626, USA.
    Along southern California beaches, the concentrations of fecal indicator bacteria (FIB) used to quantify the potential presence of fecal contamination in coastal recreational waters have been previously documented to be higher during wet weather conditions (typically winter or spring) than those observed during summer dry weather conditions. FIB are used for management of recreational waters because measurement of the bacterial and viral pathogens that are the potential causes of illness in beachgoers exposed to stormwater can be expensive, time-consuming, and technically difficult. Here, we use droplet digital Polymerase Chain Reaction (digital PCR) and digital reverse transcriptase PCR (digital RT-PCR) assays for direct quantification of pathogenic viruses, pathogenic bacteria, and source-specific markers of fecal contamination in the stormwater discharges. Read More

    Seronegativity to polio viruses among previously immunized adult candidates to solid organ transplantation.
    Braz J Infect Dis 2018 Feb 28. Epub 2018 Feb 28.
    Universidade Federal do Rio de Janeiro, Departamento de Medicina Preventiva, Rio de Janeiro, RJ, Brazil.
    In the current effort to eliminate polio from the world, it is important to recognize and vaccinate susceptible groups, especially immunocompromised patients living in countries where attenuated polio vaccine is still used. In this report, we describe the frequency of protective antibodies in a small sample of adult SOT candidates in whom previous vaccination could be ascertained. Patients included in this report were selected among the participants of an ongoing prospective study carried out at the Reference Center for Special Immunobiologicals of the Evandro Chagas National Institute of Infectious Diseases in Rio de Janeiro, Brazil. Read More

    Enterovirus D-68 in Children Presenting for Acute Care in the Hospital Setting.
    Influenza Other Respir Viruses 2018 Mar 2. Epub 2018 Mar 2.
    Seattle Children's Hospital.
    Background: Severe respiratory disease associated with enterovirus D68 (EV-D68) has been reported in hospitalized pediatric patients. Virologic and clinical characteristics of EV-D68 infections exclusively in patients presenting to a hospital Emergency Department (ED) or urgent care have not been well defined.

    Methods: Mid-nasal swabs from pediatric patients with respiratory symptoms presenting to the ED or urgent care were evaluated using a commercial multiplex PCR platform. Read More

    Progress Toward Poliomyelitis Eradication - Nigeria, January-December 2017.
    MMWR Morb Mortal Wkly Rep 2018 Mar 2;67(8):253-256. Epub 2018 Mar 2.
    Nearly three decades after the World Health Assembly launched the Global Polio Eradication Initiative in 1988, four of the six World Health Organization (WHO) regions have been certified polio-free (1). Nigeria is one of three countries, including Pakistan and Afghanistan, where wild poliovirus (WPV) transmission has never been interrupted. In September 2015, after >1 year without any reported WPV cases, Nigeria was removed from WHO's list of countries with endemic WPV transmission (2); however, during August and September 2016, four type 1 WPV (WPV1) cases were reported from Borno State, a state in northeastern Nigeria experiencing a violent insurgency (3). Read More

    Unraveling the Motions behind Enterovirus 71 Uncoating.
    Biophys J 2018 Feb;114(4):822-838
    Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey. Electronic address:
    Enterovirus 71 can be a severe pathogen in small children and immunocompromised adults. Virus uncoating is a critical step in the infection of the host cell; however, the mechanisms that control this process remain poorly understood. We applied normal mode analysis and perturbation response scanning to several complexes of the virus capsid and present a coarse-graining approach to analyze the full capsid. Read More

    Molecular detection of human enteric viruses circulating among children with acute gastroenteritis in Valencia, Venezuela, before rotavirus vaccine implementation.
    Gut Pathog 2018 22;10. Epub 2018 Feb 22.
    1Laboratorio de Biología de Virus, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas (IVIC), Apdo. 21827, Caracas, 1020 Venezuela.
    Background: The role of rotavirus as main etiologic agent of diarrhea has been well documented worldwide, including in Venezuela. However, information about the prevalence of gastrointestinal viruses such as calicivirus, adenovirus and astrovirus is limited and the contribution of other agents as Aichi virus and klassevirus is largely unknown. To explore the etiological spectrum of diarrhea associated with agents other than rotaviruses, 227 stool samples from children under 5 years old with acute gastroenteritis, collected in Valencia (Venezuela) from 2001 to 2005, and previously tested as rotavirus-negative, were analyzed for caliciviruses, adenoviruses, astroviruses, Aichi viruses, klasseviruses, picobirnaviruses and enteroviruses by specific RT-PCRs. Read More

    Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality.
    Lancet Infect Dis 2018 Feb 23. Epub 2018 Feb 23.
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA; Children's Hospital Colorado, Aurora, CO, USA.
    Increased circulation of enterovirus D68 in 2014 and 2016 temporally and geographically coincided with increases in cases of acute flaccid myelitis, an uncommon condition of paralysis due to lesions in the anterior horn of the spinal cord. The identification of enterovirus D68 in respiratory specimens from cases of acute flaccid myelitis worldwide further supports an association, yet the absence of direct virus isolation from affected tissues, infrequent detection in cerebrospinal fluid, and the absence, until recently, of an animal model has left the causal nature of the relationship unproven. In this Personal View we evaluate epidemiological and biological evidence linking enterovirus D68 and acute flaccid myelitis. Read More

    Five-year immunity persistence following immunization with inactivated enterovirus 71 type (EV71) vaccine in healthy children: a further observation.
    Hum Vaccin Immunother 2018 Feb 26:1-32. Epub 2018 Feb 26.
    a Jiangsu Province Center for Disease Control and Prevention , Nanjing , China.
    The longevity of antibodies induced by inactivated enterovirus 71 type (EV71) vaccine is not well studied. To estimate the immunity persistence following two-dose vaccination of EV71 vaccine, a five-year follow-up study was conducted as an extension of a Phase III clinical trial. In this study, a sub-cohort of volunteers who was eligible for enrollment and randomly administrated either 2 dose EV71 vaccine or placebo in the phase III clinical trial was selected, and then further observed 64 months post the 1st vaccination. Read More

    Complete genome sequence of a multi-recombinant echovirus 6 strain isolated from CSF in Ahvaz, Southwestern Iran.
    J Chin Med Assoc 2018 Apr 21;81(4):340-347. Epub 2018 Feb 21.
    Health Research Institute, Infectious and Tropical Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Virology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Background: Echovirus 6 (E6), is one of the main enteroviral serotypes, was initially isolated from patients with aseptic meningitis (AM) and is a major cause of hospitalization among children and adults worldwide.

    Methods: A cerebrospinal fluid (CSF) sample was collected from patient with clinically suspected aseptic meningitis (AM) in August 2011. Following detection of a virus and subsequent virus serotyping, the whole genome sequence was determined. Read More

    Artemisia capillaris inhibited enterovirus 71-induced cell injury by preventing viral internalization.
    Kaohsiung J Med Sci 2018 Mar 6;34(3):150-159. Epub 2017 Dec 6.
    Department of Renal Care, College of Medicine, Kaohsiung Medical University, Taiwan; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. Electronic address:
    Artemisia capillaris (A. capillaris) is a common herbal drug used for thousands years in ancient China. A. Read More

    Monitoring human enteric viruses in wastewater and relevance to infections encountered in the clinical setting: a one-year experiment in central France, 2014 to 2015.
    Euro Surveill 2018 Feb;23(7)
    CHU Clermont-Ferrand, Centre National de Référence Entérovirus et parechovirus - Laboratoire Associé, Laboratoire de Virologie, Clermont-Ferrand, France.
    BackgroundHuman enteric viruses are resistant in the environment and transmitted via the faecal-oral route. Viral shedding in wastewater gives the opportunity to track emerging pathogens and study the epidemiology of enteric infectious diseases in the community.The aim of this study was to monitor the circulation of enteric viruses in the population of the Clermont-Ferrand area (France) by analysis of urban wastewaters. Read More

    Viral and Bacterial Etiologies of Acute Respiratory Infections Among Children Under 5 Years in Senegal.
    Microbiol Insights 2018 13;11:1178636118758651. Epub 2018 Feb 13.
    Laboratory of Bacteriology and Virology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal.
    Acute respiratory infections (ARIs) are the leading cause of infectious disease-related morbidity, hospitalization, and morbidity among children worldwide. This study aimed to assess the viral and bacterial causes of ARI morbidity and mortality in children under 5 years in Senegal. Nasopharyngeal samples were collected from children under 5 years who had ARI. Read More

    Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells.
    J Virol 2018 Feb 21. Epub 2018 Feb 21.
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Human adenoviruses (HAdV) are significant human pathogens. Although only a subset of HAdV serotypes commonly cause gastroenteritis in humans, most HAdV species replicate in the gastrointestinal tract. Knowledge of the complex interaction between HAdVs and the human intestinal epithelium has been limited by the lack of a suitable cell culture system containing relevant cell types. Read More

    Fibronectin facilitates EV71 infection by mediating its entry.
    J Virol 2018 Feb 21. Epub 2018 Feb 21.
    The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Fibronectin (FN) is a high molecular weight extracellular matrix protein that contains RGDS motif, which is required to bind to integrins. Synthetic RGDS peptides have been reported to compete with FN to bind to the cell surface and inhibit the function of FN. Here, we identified that synthetic RGDS peptides significantly inhibit human enterovirus 71 (EV71) infection in cell cultures. Read More

    Variability in Disinfection Resistance between Currently Circulating Enterovirus B Serotypes and Strains.
    Environ Sci Technol 2018 Mar 2;52(6):3696-3705. Epub 2018 Mar 2.
    Laboratory of Environmental Chemistry, School of Architecture, Civil and Environmental Engineering , École Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne , Switzerland.
    The susceptibility of waterborne viruses to disinfection is known to vary between viruses and even between closely related strains, yet the extent of this variation is not known. Here, different enteroviruses (six strains of coxsackievirus B5, two strains of coxsackievirus B4 and one strain of coxackievirus B1) were isolated from wastewater and inactivated by UV, sunlight, free chlorine (FC), chlorine dioxide (ClO), and heat. Inactivation kinetics of these isolates were compared with those of laboratory enterovirus strains (CVB5 Faulkner and echovirus 11 Gregory) and MS2 bacteriophage. Read More

    Strain-dependent effects of clinical echovirus 30 outbreak isolates at the blood-CSF barrier.
    J Neuroinflammation 2018 Feb 20;15(1):50. Epub 2018 Feb 20.
    Pediatric Infectious Diseases, University Children's Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
    Background: Echovirus (E) 30 (E-30) meningitis is characterized by neuroinflammation involving immune cell pleocytosis at the protective barriers of the central nervous system (CNS). In this context, infection of the blood-cerebrospinal fluid barrier (BCSFB), which has been demonstrated to be involved in enteroviral CNS pathogenesis, may affect the tight junction (TJ) and adherens junction (AJ) function and morphology.

    Methods: We used an in vitro human choroid plexus epithelial (HIBCPP) cell model to investigate the effect of three clinical outbreak strains (13-311, 13-759, and 14-397) isolated in Germany in 2013, and compared them to E-30 Bastianni. Read More

    Aetiology of acute encephalitis syndrome in Uttar Pradesh, India from 2014 to 2016.
    J Vector Borne Dis 2017 Oct-Dec;54(4):311-316
    Department of Microbiology, King George's Medical University, Lucknow, India.
    Background & Objectives: It is imperative to know the aetiology of acute encephalitis syndrome (AES) for patient management and policy making. The present study was carried out to determine the prevalence of common aetiological agents of AES in Uttar Pradesh (UP) state of India.

    Methods: Serum and/or CSF samples were collected from AES patients admitted at Gandhi Memorial and Associated Hospital, King George's Medical University, Lucknow, a tertiary care centre, UP during 2014-16. Read More

    Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015.
    Emerg Infect Dis 2018 Mar;24(3)
    Using China's national surveillance data on hand, foot and mouth disease (HFMD) for 2008-2015, we described the epidemiologic and virologic features of recurrent HFMD. A total of 398,010 patients had HFMD recurrence; 1,767 patients had 1,814 cases of recurrent laboratory-confirmed HFMD: 99 reinfections of enterovirus A71 (EV-A71) with EV-A71, 45 of coxsackievirus A16 (CV-A16) with CV-A16, 364 of other enteroviruses with other enteroviruses, 383 of EV-A71 with CV-A16 and CV-A16 with EV-A71, and 923 of EV-A71 or CV-A16 with other enteroviruses and other enteroviruses with EV-A71 or CV-A16. The probability of HFMD recurrence was 1. Read More

    Honeysuckle-encoded microRNA2911 inhibits Enterovirus 71 replication via targeting VP1 gene.
    Antiviral Res 2018 Apr 16;152:117-123. Epub 2018 Feb 16.
    Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:
    Enterovirus 71 (EV71) is the primary pathogen of hand-foot-and-mouth disease (HFMD) in children and virus infections are associated with severe neurological dysfunctions and even death. MIR2911 is a honeysuckle-encoded atypical microRNA with extreme stability. Here, we report that MIR2911 directly inhibits EV71 replication by targeting the VP1 gene. Read More

    Identification and characterization of neutralization epitopes at VP2 and VP1 of enterovirus A71.
    J Med Virol 2018 Feb 19. Epub 2018 Feb 19.
    Faculty of Medicine, Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.
    Enterovirus A71 (EV-A71) neutralization escape mutants were generated with monoclonal antibody MAB979 (Millipore). The VP2-T141I and VP1-D14N substitutions were identified. Using reverse genetics, infectious clones with these substitutions were constructed and tested by neutralization assay with immune sera from mice and humans. Read More

    1 OF 502