121 results match your criteria Cough [Journal]


A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers.

Cough 2014 24;10(1). Epub 2014 Dec 24.

Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy.

Background: Persistent dry cough is a well known unwanted effect of Angiotensin-Converting Enzyme inhibitors (ACE-i). Animal studies have shown that the ACE-i zofenopril has a less tussigenic effect compared to the widely used ACE-i ramipril. The aim of this study was to compare cough sensitivity to inhaled tussigens, as well as spontaneous cough in response to the administration of zofenopril and ramipril in healthy volunteers; pharmacokinetic (PK) data of both zofenopril and ramipril, as well as their respective active forms, zofenoprilat and ramiprilat, was also collected. Read More

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http://dx.doi.org/10.1186/s12997-014-0007-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308941PMC
January 2015
10 Reads

Standardized method for solubility and storage of capsaicin-based solutions for cough induction.

Cough 2014 25;10. Epub 2014 Sep 25.

Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA.

Background: Preparation of inhaled capsaicin solutions for cough induction varies greatly from one lab to another, which creates inconsistencies between tussigenic challenge results. The addition of Tween to these capsaicin solutions provides increased solubility and stability; however, the foul taste of Tween makes inhaling the solution for any prolonged period of time unpleasant. We sought to create a standard method for preparing soluble and stable capsaicin-based solutions (in 10% ethanol/water), without the addition of Tween. Read More

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
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http://dx.doi.org/10.1186/1745-9974-10-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194457PMC
October 2014
12 Reads

On the definition of chronic cough and current treatment pathways: an international qualitative study.

Cough 2014 29;10. Epub 2014 May 29.

Department of Cardiovascular and Respiratory Studies, University of Hull and the Hull York Medical School, Castle Hill Hospital, Cottingham, UK.

Background: The pathogenesis of chronic cough is not well understood and treatment options are limited. In this study we sought to explore the current understanding and management of chronic cough across an international group of specialists.

Methods: This was an international study of cross sectional qualitative design. Read More

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http://dx.doi.org/10.1186/1745-9974-10-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088926PMC
July 2014
5 Reads

Effect of acid suppression therapy on gastroesophageal reflux and cough in idiopathic pulmonary fibrosis: an intervention study.

Cough 2014 30;10. Epub 2014 Apr 30.

Department of Respiratory Medicine, Cardiff and Vale University Health Board, Cardiff, UK.

Background: Chronic cough affects more than 70 percent of patients with Idiopathic Pulmonary Fibrosis and causes significant morbidity. Gastroesophageal reflux is the cause of some cases of chronic cough; and also has a postulated role in the aetiology of Idiopathic Pulmonary Fibrosis. A high prevalence of acid; and more recently non-acid, reflux has been observed in Idiopathic Pulmonary Fibrosis cohorts. Read More

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http://dx.doi.org/10.1186/1745-9974-10-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038107PMC
May 2014
7 Reads

Severity of cough in idiopathic pulmonary fibrosis is associated with MUC5 B genotype.

Cough 2014 25;10. Epub 2014 Mar 25.

Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Background: A polymorphism (rs35705950) in the promoter region of the mucin MUC5B is associated with both familial and sporadic forms of idiopathic pulmonary fibrosis. (IPF) We hypothesize that this common MUC5B variant will impact the expression of cough, a frequent disabling symptom seen in subjects with IPF.

Methods: We genotyped 136 subjects with IPF. Read More

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http://dx.doi.org/10.1186/1745-9974-10-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038402PMC
August 2014
19 Reads

A real - life observational pilot study to evaluate the effects of two-week treatment with montelukast in patients with chronic cough.

Cough 2014 Mar 20;10(1). Epub 2014 Mar 20.

Clinical centre of Allergy and Asthma, Alexander's University Hospital, 1 Georgi Sofyiski Str, 1431 Sofia, Bulgaria.

Background: Different conditions make the proximal airways susceptible to tussigenic stimuli in the chronic cough (CC) syndrome. Leukotrienes can be implicated in the inflammatory mechanism at play in it. Montelukast is a selective cysteinyl-leukotriene receptor antagonist with proven effectiveness in patients with asthma. Read More

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http://dx.doi.org/10.1186/1745-9974-10-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994549PMC
March 2014
19 Reads
3 Citations

Development and validation of the Newcastle laryngeal hypersensitivity questionnaire.

Cough 2014 Feb 19;10(1). Epub 2014 Feb 19.

Speech Pathology Department, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, NSW 2310, Australia.

Background: Laryngeal hypersensitivity may be an important component of the common disorders of laryngeal motor dysfunction including chronic refractory cough, pdoxical vocal fold movement (vocal cord dysfunction), muscle tension dysphonia, and globus pharyngeus. Patients with these conditions frequently report sensory disturbances, and an emerging concept of the 'irritable larynx' suggests common features of a sensory neuropathic dysfunction as a part of these disorders. The aim of this study was to develop a Laryngeal Hypersensitivity Questionnaire for patients with laryngeal dysfunction syndromes in order to measure the laryngeal sensory disturbance occurring in these conditions. Read More

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http://dx.doi.org/10.1186/1745-9974-10-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931290PMC
February 2014
6 Reads

Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire.

Cough 2013 Dec 31;9(1):27. Epub 2013 Dec 31.

Nutrition & Dietetics Department, Castle Hill Hospital, Hull & East Yorkshire NHS Trust, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK.

Background: Chronic cough is a common and distressing symptom. Gastro-oesophageal reflux is a common cause of chronic cough however the symptom complex in cough is not confined to classic peptic symptoms. Dyspeptic symptoms have previously been shown to respond to dietary modifications and weight loss. Read More

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http://dx.doi.org/10.1186/1745-9974-9-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883462PMC
December 2013
8 Reads

Airway oxidative stress in chronic cough.

Cough 2013 Dec 2;9(1):26. Epub 2013 Dec 2.

Unit for Medicine and Clinical Research, Pulmonary Division, Kuopio University Hospital, PL 1777, 70211 Kuopio, Finland.

Background: The mechanisms of chronic cough are unclear. Many reactive oxygen species affect airway sensory C-fibres which are capable to induce cough. Several chronic lung diseases are characterised by cough and oxidative stress. Read More

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http://dx.doi.org/10.1186/1745-9974-9-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176500PMC
December 2013
7 Reads

Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial.

Cough 2013 Nov 21;9(1):25. Epub 2013 Nov 21.

Norderney Hospital, Kaiserstr, 26, Norderney D-26548, Germany.

Objective: Cineole has mucolytic, bronchodilating and anti-inflammatory properties and reduces the exacerbation rate in patients suffering from COPD, as well as ameliorates symptoms in patients suffering from asthma and rhinosinusitis. Based on these effects, we therefore postulated the hypothesis that patients with acute bronchitis would also benefit from therapy with Cineole.

Methods: As part of a double-blind, placebo-controlled, multi-center-study, a total of 242 patients with confirmed acute bronchitis was randomly selected to participate. Read More

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http://dx.doi.org/10.1186/1745-9974-9-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842692PMC
November 2013
6 Reads

Chronic cough and obstructive sleep apnoea in a sleep laboratory-based pulmonary practice.

Cough 2013 Nov 5;9(1):24. Epub 2013 Nov 5.

Department of Thoracic Medicine, Chang Gung Memorial Hospital and Chang Gung University, School of Medicine, 199 Tun-Hwa N, Rd,, Taipei, Taiwan.

Background: Obstructive sleep apnoea (OSA) has recently been identified as a possible aetiology for chronic cough. The aim of this study was to compare the incidence of chronic cough between patients with and without OSA and the impact of continuous positive airway pressure (CPAP) treatment in resolving chronic cough.

Methods: Patients referred to the sleep laboratory from January 2012 to June 2012 were retrospectively enrolled. Read More

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http://dx.doi.org/10.1186/1745-9974-9-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176501PMC
November 2013
7 Reads
2 Citations

Altitude-related cough.

Authors:
Nicholas P Mason

Cough 2013 Oct 31;9(1):23. Epub 2013 Oct 31.

Consultant in Critical Care Medicine, Royal Gwent Hospital, Newport NP20 2UB, UK.

Altitude-related cough is a troublesome condition of uncertain aetiology that affects many visitors to high altitude. The traditionally held belief that it was due solely to the inspiration of cold, dry air was refuted by observations and experiments in long duration hypobaric chamber studies. It is likely that altitude-related cough is a symptom of a number of possible perturbations in the cough reflex arc that may exist independently or together. Read More

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http://dx.doi.org/10.1186/1745-9974-9-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176487PMC
October 2013
5 Reads

Inhibitory effect of cervical trachea and chest wall vibrations on cough reflex sensitivity and perception of urge-to-cough in healthy male never-smokers.

Cough 2013 Oct 2;9(1):22. Epub 2013 Oct 2.

Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Seiryo-machi 1-1, Aoba-ku, Sendai,, 980-8574, Japan.

Background: Non-pharmacological options for symptomatic management of cough are desired. Although chest wall mechanical vibration is known to ameliorate cough reflex sensitivity, the effect of mechanical vibrations on perceptions of urge-to-cough has not been studied. Therefore, we investigated the effect of mechanical vibration of cervical trachea, chest wall and femoral muscle on cough reflex sensitivity, perceptions of urge-to-cough as well as dyspnea. Read More

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
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http://dx.doi.org/10.1186/1745-9974-9-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850014PMC
October 2013
5 Reads

Resuscitation and auto resuscitation by airway reflexes in animals.

Cough 2013 Aug 22;9(1):21. Epub 2013 Aug 22.

Department of Human Physiology Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia.

Various diseases often result in decompensation requiring resuscitation. In infants moderate hypoxia evokes a compensatory augmented breath - sigh and more severe hypoxia results in a solitary gasp. Progressive asphyxia provokes gasping respiration saving the healthy infant - autoresuscitation by gasping. Read More

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http://dx.doi.org/10.1186/1745-9974-9-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828820PMC
August 2013
6 Reads

Intravenous lidocaine suppresses fentanyl-induced cough in Children.

Cough 2013 15;9:20. Epub 2013 Aug 15.

Emergency Center, University Clinical Centre of Kosova, Prishtina, Kosova.

Objective: Fentanyl-induced cough is usually mild and transitory, but it can be undesirable in patients with increased intracranial pressure, open wounds of the eye, dissecting aortic aneurism, pneumothorax, and reactive airway disease. The aim of this study is to evaluate the efficacy of lidocaine in suppressing fentanyl-induced cough in children during induction in general anesthesia.

Methods: One hundred and eighty-six children of both sexes, aged between 4-10 years, ASA physical status I and II, and scheduled for elective surgery, were recruited for the study. Read More

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http://dx.doi.org/10.1186/1745-9974-9-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751768PMC
May 2014
6 Reads

A longitudinal study of CPAP therapy for patients with chronic cough and obstructive sleep apnoea.

Cough 2013 Jul 11;9(1):19. Epub 2013 Jul 11.

Department of Medicine, University of Utah, Salt Lake City, UT, USA.

Background: Chronic cough patients are rendered therapies for gastro-esophageal reflux (GERD), upper airway cough syndrome (UACS) and cough-variant asthma (CVA) with varying benefit. Idiopathic or unexplained cough has emerged as an important clinical entity in both primary care and subspecialty clinics. Recent evidence points to a link between chronic cough and untreated obstructive sleep apnea (OSA). Read More

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
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http://dx.doi.org/10.1186/1745-9974-9-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722026PMC
July 2013
10 Reads

Epidemiology of cough in relation to China.

Cough 2013 Jul 8;9(1):18. Epub 2013 Jul 8.

State Key Laboratory of Respiratory Diseases, 1st Affiliated Hospital, Guangzhou Medical College, Guangzhou, GZ, China.

Cough is one of the most common complaints for which patients seek medical attention. Misdiagnosis and mistreatment of cough exist commonly in China. The prevalence of acute cough caused by upper airway infection fluctuates between 9% and 64% in the community, for chronic cough, the prevalence >10% in most surveys, ranging from 7. Read More

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http://www.coughjournal.com/content/pdf/1745-9974-9-18.pdf
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http://www.coughjournal.com/content/9/1/18
Publisher Site
http://dx.doi.org/10.1186/1745-9974-9-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711853PMC
July 2013
33 Reads

Cough in chronic obstructive pulmonary disease: is it important and what are the effects of treatment?

Cough 2013 24;9:17. Epub 2013 Jun 24.

Clinical Sciences Centre, University Hospital Aintree, Lower Lane, L9, 7AL, Liverpool, United Kingdom ; University of Liverpool, Lower Lane, L9, 7AL, Liverpool, United Kingdom.

Over the last 40 years the assessment and treatment of chronic obstructive pulmonary disease has focused primarily on airflow obstruction with little significance given to the problem of cough. The reasons for this include a view that cough arises simply from the direct irritant and inflammatory effect of cigarette smoke or the presence of excess mucus in the airways. Doubt that cough is of any consequence to patients or responsive to current therapies has reinforced this opinion. Read More

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http://dx.doi.org/10.1186/1745-9974-9-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701496PMC
June 2014
4 Reads

The larynx in cough.

Cough 2013 Jun 3;9(1):16. Epub 2013 Jun 3.

Consultant Otolaryngologist, Imperial College London, London, UK.

About 40% of the population will experience chronic cough at some point during their lives and it tends to be more common in women (Thorax 58:901-7, 2003). Post-nasal drip (or upper airway cough syndrome), gastro-esophageal reflux disease and asthma are considered the most common causes. Yet only a small percentage of patients with these common conditions experience chronic cough. Read More

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http://dx.doi.org/10.1186/1745-9974-9-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704827PMC
June 2013
5 Reads

Capability of hypertonic saline cough provocation test to predict the response to inhaled corticosteroids in chronic cough: a prospective, open-label study.

Cough 2013 20;9:15. Epub 2013 May 20.

Unit for Medicine and Clinical Research, Pulmonary Division, Kuopio University Hospital, PL 1777, Kuopio 70211, Finland.

Background: Many patients with chronic cough respond to treatment with inhaled corticosteroids but it is difficult to predict which patients are likely to respond. The primary aim of the present study was to define the capability of hypertonic saline cough provocation test to predict the responsiveness to inhaled corticosteroids in chronic cough. The secondary aim was to assess the ability of the saline test to monitor the healing of cough during corticosteroid treatment. Read More

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http://dx.doi.org/10.1186/1745-9974-9-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669106PMC
May 2014
8 Reads

Chronic cough hypersensitivity syndrome.

Authors:
Alyn H Morice

Cough 2013 May 13;9(1):14. Epub 2013 May 13.

Cardiovascular & Respiratory Studies, Respiratory Medicine, Hull York Medical School, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK.

Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by afferent neuronal hypersensitivity and different aspects of this syndrome are manifest in the different phenotypes of cough. There are several advantages to viewing cough hypersensitivity as the unifying diagnosis; Communication with patients is aided, aetiology is not restricted and therapeutic avenues opened. Read More

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http://dx.doi.org/10.1186/1745-9974-9-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655896PMC
May 2013
7 Reads

Summary of papers presented at the 2012 seventh international cough symposium.

Cough 2013 May 2;9(1):13. Epub 2013 May 2.

Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536-0298, USA.

Twenty six papers were presented as posters in the Seventh International Symposium on Cough; 12 papers were presented in the Basic Science of Cough session, and 14 papers presented in the Clinical Science of Cough session. These papers explored a wide spectrum of cough-related areas including pathophysiological mechanisms, treatment and detection of cough, and symptom assessment and perception, and were grouped into several general themes for facilitate the discussion. Studies presented in these posters have provided new information that should improve our knowledge on the basic physiology and pharmacology of cough, and the peripheral and central neural mechanisms involved in the generation of the cough motor pattern. Read More

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http://dx.doi.org/10.1186/1745-9974-9-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655108PMC
May 2013
5 Reads

The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes.

Cough 2013 Apr 16;9(1):12. Epub 2013 Apr 16.

Respiratory and Allergy Centre, The University of Manchester, University Hospital of South Manchester, Manchester, UK.

Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed. Read More

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http://dx.doi.org/10.1186/1745-9974-9-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640905PMC
April 2013
5 Reads

The difficult coughing child: prolonged acute cough in children.

Cough 2013 Apr 10;9(1):11. Epub 2013 Apr 10.

Respiratory Medicine, Royal Belfast Hospital for Sick Children, Centre for Infection & Immunity, Queen's University Belfast, Health Sciences Building, 97 Lisburn Road, Belfast, Bt7 9BL, N Ireland, UK.

Cough is one of the most common symptoms that patients bring to the attention of primary care clinicians. Cough can be designated as acute (<3 weeks in duration), prolonged acute cough (3 to 8 weeks in duration) or chronic (> 8 weeks in duration). The use of the term 'prolonged acute cough' in a cough guideline allows a period of natural resolution to occur before further investigations are warranted. Read More

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
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http://dx.doi.org/10.1186/1745-9974-9-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637271PMC
April 2013
8 Reads

Refractory chronic cough, or the need to focus on the relationship between the larynx and the esophagus.

Cough 2013 Apr 3;9(1):10. Epub 2013 Apr 3.

Chronic Cough Unit, Pneumology Service, Hospital Ramón y Cajal, Madrid, Spain.

In this review we question the current way of handling tackle a problem of chronic cough, especially by the excessive number of patients who can not find complete relief from your cough by anatomical diagnosis of universal use. From the field of Otolaryngology new perspectives arise now considering the larynx as a preferential afferent stimuli cough reflex arc. Also the constitution laryngopharyngeal reflux gas and new approaches to non-acid reflux and the local action of pepsin in laryngeal deserving of a joint review, which can illuminate new ways to handle the problem of chronic refractory cough. Read More

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http://dx.doi.org/10.1186/1745-9974-9-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687571PMC
April 2013
4 Reads

Molecular signaling and targets from itch: lessons for cough.

Cough 2013 Mar 6;9(1). Epub 2013 Mar 6.

The Solomon H, Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD, 21205, USA.

Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. Read More

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
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http://dx.doi.org/10.1186/1745-9974-9-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630061PMC
March 2013
12 Reads

Sensorimotor circuitry involved in the higher brain control of coughing.

Cough 2013 Mar 6;9(1). Epub 2013 Mar 6.

School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.

There is an overwhelming body of evidence to support the existence of higher brain circuitries involved in the sensory detection of airways irritation and the motor control of coughing. The concept that cough is purely a reflex response to airways irritation is now superseded by the recognition that perception of an urge-to-cough and altered behavioral modification of coughing are key elements of cough disorders associated with airways disease. Understanding the pathways by which airway sensory nerves ascend into the brain and the patterns of neural activation associated with airways irritation will undoubtedly provide new insights into disordered coughing. Read More

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http://dx.doi.org/10.1186/1745-9974-9-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602068PMC
March 2013
9 Reads

John Widdicombe's contribution to respiratory physiology and cough: reminiscences.

Cough 2013 Mar 6;9(1). Epub 2013 Mar 6.

National Heart & Lung Institute, Imperial College London & Biomedical Research Unit, Royal Brompton Hospital, Dovehouse St, London, SW3 6LY, UK.

John Widdicombe has made substantial contributions to respiratory physiology and to the field of cough particularly. He was one of the first to characterise Aδ-myelinated fibres in the airways that could mediate cough and increased breathing. Later on, he initiated the series of international London Cough Symposia that gathered researchers and clinicians on a two-yearly basis to discuss recent results and concepts regarding cough. Read More

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http://dx.doi.org/10.1186/1745-9974-9-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601007PMC
March 2013
5 Reads

Cough, sarcoidosis and idiopathic pulmonary fibrosis: raw nerves and bad vibrations.

Cough 2013 Mar 6;9(1). Epub 2013 Mar 6.

College of Medicine, Swansea University, Swansea, Wales, UK.

Cough is a common symptom in people who develop interstitial lung diseases (ILD). The pathological features of the ILDs are many and varied suggesting that the cause of cough may also vary with each disease. This article reviews what is currently known about cough in sarcoidosis and idiopathic pulmonary fibrosis; two of the commonest ILDs. Read More

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http://dx.doi.org/10.1186/1745-9974-9-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605326PMC
March 2013
4 Reads

Capsaicin sensitivity in patients with chronic cough- results from a cross-sectional study.

Cough 2013 Feb 28;9(1). Epub 2013 Feb 28.

Department of Allergology, Institution of Internal Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Background: A subgroup of patients with chronic cough is recognised as having airway symptoms resulting exposure to chemicals and scents related to enhanced cough sensitivity to inhaled capsaicin. Sensory hyperreactivity, which has an estimated prevalence of more than 6%, is one possible explanation for the symptoms experienced by these patients. We hypothesized that a number of patients diagnosed with chronic unexplained cough also have coughing provoked by chemical irritants associated with augmented capsaicin cough reaction, but the extent of such a relation is not known. Read More

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http://dx.doi.org/10.1186/1745-9974-9-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598875PMC
February 2013
4 Reads

Classification of chronic cough by systematic treatment cascade trial starting with beta agonist.

Cough 2013 Feb 7;9(1). Epub 2013 Feb 7.

Department of Internal Medicine, Division of Respiratory Medicine and Clinical Allergy, Fujita Health University, 1-98 Dengakugakubo Kutsukakecho, Toyoake, 470-1192, Japan.

Background: Chronic cough is one of the most challenging symptoms to diagnose and treat, not only because of the variety of underlying disorders but also its varying susceptibility to treatments. Etiological studies of chronic cough vary depending on the clinical settings and the particular interests of investigators.

Objectives: The purposes of this study were first to categorize the etiology of chronic cough by its response to systematic diagnostic treatments starting from the β2 agonist and second to sub-categorize β2 agonist responsive cough (BRC) by the airway hyperresponsiveness. Read More

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http://dx.doi.org/10.1186/1745-9974-9-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602065PMC
February 2013
6 Reads

Fentanyl enhances the excitability of rapidly adapting receptors to cause cough via the enhancement of histamine release in the airways.

Cough 2013 Feb 1;9(1). Epub 2013 Feb 1.

Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa, Tokyo 142-8501, Japan.

Unlabelled:

Background: Although the mechanism of fentanyl-induced cough is unclear, several lines of evidence suggest that allergic mediators, such as histamine, may play a role in the production of fentanyl-induced coughs. The aim of this study was to explore the effects of fentanyl on cough sensitivity to inhaled citric acid and on histamine release in BALF in mice.

Methods: The cough reflex was induced by the inhalation of citric acid. Read More

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
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http://dx.doi.org/10.1186/1745-9974-9-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566957PMC
February 2013
16 Reads

Management of patients with chronic cough using a clinical protocol: a prospective observational study.

Cough 2013 Jan 24;9(1). Epub 2013 Jan 24.

Department of Cardiovascular and Respiratory Studies, Castle Hill Hospital, University of Hull, Cottingham, HU16 5JQ, UK.

Unlabelled:

Background And Aims: Chronic cough is a common symptom the aetiology of which can be challenging to diagnose. Diagnostic protocols for chronic cough have required the use of specialist investigations which are not always easily available. We wanted to determine whether patients with chronic cough can be successfully managed using a clinical algorithm. Read More

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
Publisher Site
http://dx.doi.org/10.1186/1745-9974-9-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565860PMC
January 2013
8 Reads

Clinical experience with low-dose itraconazole in chronic idiopathic cough.

Cough 2013 Jan 14;9(1). Epub 2013 Jan 14.

The Division of Pulmonary Medicine, Ishikawa-ken Saiseikai Kanazawa Hospital, Ni-13-6 Akatsuchi-machi, Kanazawa, 920-0353, Japan.

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Background: The presence of basidiomycetous (BM) fungi in induced sputum is an important clinical finding in chronic idiopathic cough (CIC). However, the efficacy of anti-fungal therapy for CIC has not been evaluated.

Methods: We selected 10 patients with CIC and carried out allergological examinations for Bjerkandera adusta, a BM fungus that has been shown to enhance cough severity. Read More

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http://dx.doi.org/10.1186/1745-9974-9-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562166PMC
January 2013
6 Reads

Data reduction for cough studies using distribution of audio frequency content.

Cough 2012 Dec 12;8(1):12. Epub 2012 Dec 12.

Respiratory Research Group, Manchester Academic Health Sciences Centre, University of Manchester, University Hospital of South Manchester, ERC Building, Second floor, Manchester, M23 9LT, United Kingdom.

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Background: Recent studies suggest that objectively quantifying coughing in audio recordings offers a novel means to understand coughing and assess treatments. Currently, manual cough counting is the most accurate method for quantifying coughing. However, the demand of manually counting cough records is substantial, demonstrating a need to reduce record lengths prior to counting whilst preserving the coughs within them. Read More

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http://dx.doi.org/10.1186/1745-9974-8-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546839PMC
December 2012
4 Reads

Modulation of cough response by sensory inputs from the nose - role of trigeminal TRPA1 versus TRPM8 channels.

Cough 2012 Dec 3;8(1):11. Epub 2012 Dec 3.

Department of Pathophysiology, Comenius University, Jessenius Faculty of Medicine Martin, Sklabinska Str, 26, Martin, 036 01, Slovak Republic.

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Background: Cough, the most important airways defensive mechanism is modulated by many afferent inputs either from respiratory tussigenic areas, but also by afferent drive from other organs. In animal models, modulation of cough by nasal afferent inputs can either facilitate or inhibit the cough response, depending on the type of trigeminal afferents stimulated.

Methods: In this study we addressed the question of possible bidirectional modulation of cough response in human healthy volunteers by nasal challenges with TRPA1 and TRPM8 agonists respectively. Read More

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http://dx.doi.org/10.1186/1745-9974-8-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546011PMC
December 2012
4 Reads

Review: Effect of drugs on human cough reflex sensitivity to inhaled capsaicin.

Cough 2012 Nov 12;8(1):10. Epub 2012 Nov 12.

Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.

Capsaicin, the pungent extract of red peppers, has been used in clinical research for almost three decades. Capsaicin has gained favor as the provocative agent of choice to measure cough reflex sensitivity, as it induces cough in a safe, reproducible, and dose-dependent manner. One of the major uses of capsaicin cough challenge testing has been to evaluate the effect of a pharmacological intervention on the human cough reflex. Read More

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http://dx.doi.org/10.1186/1745-9974-8-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514321PMC
November 2012
5 Reads

A cohort description and analysis of the effect of gabapentin on idiopathic cough.

Cough 2012 Nov 1;8(1). Epub 2012 Nov 1.

Department of Respiratory Disease, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium.

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Background: Chronic idiopathic cough (known as cough hypersensitivity syndrome) is defined by cough in the absence of an identifiable cause. Gabapentin has been suggested as a treatment but evidence is scarce. The aim of our study was to describe the clinical features of patients with unexplained chronic cough and to investigate the effect of gabapentin (600 mg twice a day for a minimal duration of 4 weeks) in reducing cough symptoms. Read More

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http://dx.doi.org/10.1186/1745-9974-8-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538532PMC
November 2012
4 Reads

Successful resolution of refractory chronic cough induced by gastroesophageal reflux with treatment of baclofen.

Cough 2012 Oct 18;8(1). Epub 2012 Oct 18.

Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, No, 389 Xincun Road, Shanghai, 200065, China.

Gastroesophageal reflux induced cough is a common cause of chronic cough, and proton pump inhibitors are a standard therapy. However, the patients unresponsive to the standard therapy are difficult to treat and remain a challenge to doctors. Here, we summarized the experience of successful resolution of refractory chronic cough due to gastroesophageal reflux with baclofen in three patients. Read More

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
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http://dx.doi.org/10.1186/1745-9974-8-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500706PMC
October 2012
5 Reads

Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs: comparison to baclofen and other GABAB receptor-selective agonists.

Cough 2012 Oct 1;8(1). Epub 2012 Oct 1.

Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland, 21224, USA.

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Background: Gastroesophageal reflux disease (GERD) is a common cause of chronic cough. Both acid and nonacid reflux is thought to play a role in the initiation of coughing and cough hypersensitivity. The GABAB receptor agonist lesogaberan was developed as a peripherally restricted anti-reflux therapy that reduces the frequency of transient lower esophageal sphincter relaxations (TLESR; the major cause of reflux) in animals and in patients with GERD. Read More

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http://dx.doi.org/10.1186/1745-9974-8-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520872PMC
October 2012
19 Reads

Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology.

Cough 2012 Sep 28;8(1). Epub 2012 Sep 28.

Division of Cardiovascular and Respiratory Studies, Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham HU16 5JQ, UK.

Chronic cough is a common symptom carrying significant morbidity which can occur as a result of oesophageal dysmotility. Here we report 2 patients with musculoskeletal disease presenting with chronic cough to our tertiary cough clinic. Prior to referral both patients had been extensively investigated to determine the basis of their cough, with no cause found. Read More

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http://dx.doi.org/10.1186/1745-9974-8-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500721PMC
September 2012
5 Reads

PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study.

Cough 2012 Sep 14;8(1). Epub 2012 Sep 14.

Respiratory Research Group, Faculty of Medical and Human Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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Background: Viral respiratory tract infection is the most frequent cause of acute cough and is reported at onset in about one third of patients with chronic cough. Persistent infection is therefore one possible explanation for the cough reflex hypersensitivity and pulmonary inflammation reported in chronic cough patients.

Methods: Bronchoscopic endobronchial biopsies and bronchoalveolar lavage cell counts were obtained from ten healthy volunteers and twenty treatment resistant chronic cough patients (10 selected for lavage lymphocytosis). Read More

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http://dx.doi.org/10.1186/1745-9974-8-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496690PMC
September 2012
8 Reads

Diagnosis and treatment of chronic cough in China: an insight into the status quo.

Cough 2012 Jul 28;8(1). Epub 2012 Jul 28.

State Key Laboratory of Respiratory Diseases, 1st Affiliated Hospital, Guangzhou Medical College, Guangzhou, GZ, China.

Chronic cough is a very common complaint in clinics throughout China. Clinical and basic science research on chronic cough started late, but in recent years the effort has yielded promising findings regarding the etiological diagnosis, treatment and pathogenesis. We found that inflammation in nonasthmatic eosinophilic bronchitis has some similarities to cough variant asthma but also a number of distinct differences. Read More

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http://dx.doi.org/10.1186/1745-9974-8-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548694PMC
July 2012
4 Reads

Fundoplication in chronic intractable cough.

Cough 2012 Jul 19;8(1). Epub 2012 Jul 19.

Department of Cardiovascular and Respiratory Studies, Castle Hill Hospital, Hull York Medical School, University of Hull, Cottingham, HU16 5JQ, UK.

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Background: Airway reflux is a common cause of chronic cough and this is often refractory to medical therapy. Surgery in the form of Nissen fundoplication has been highly successful in the treatment of the classic reflux symptoms of heartburn and dyspepsia. There is a paucity of data regarding response to fundoplication in patients presenting with chronic cough. Read More

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http://dx.doi.org/10.1186/1745-9974-8-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499264PMC
July 2012
6 Reads

Seasonal variations of cough reflex sensitivity in elite athletes training in cold air environment.

Cough 2012 Mar 26;8(1). Epub 2012 Mar 26.

Centre de recherche de l'Institut universitaire de cardiologie et de Pneumologie de Québec, 2725 Chemin Ste-Foy, Québec, Qc G1V 4G5, Canada.

Background: Exercise-induced cough is common among athletes. Athletes training in cold air often report an increasingly troublesome cough during the winter season. Chronic airway irritation or inflammation may increase the sensory response of cough receptors. Read More

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http://dx.doi.org/10.1186/1745-9974-8-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356236PMC
March 2012
5 Reads

An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome.

Cough 2012 Jan 23;8(1). Epub 2012 Jan 23.

Respiratory Medicine and Pulmonary Rehabilitation Section, Clinic Center, Private Hospital, Naples, Italy.

Background: Cough is one of the most frequent symptoms in children and is the most common symptom for which children visit a health care provider.

Methods: This is an observational study on acute cough associated with upper respiratory tract infection (URTI) in children. The study evaluates the epidemiology and impact of cough on quality of sleep and children's activities, and the outcome of cough with antitussive treatments in pediatric routine clinical practice. Read More

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http://dx.doi.org/10.1186/1745-9974-8-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274450PMC
January 2012
39 Reads

The objective assessment of cough frequency: accuracy of the LR102 device.

Cough 2011 Dec 1;7(1):11. Epub 2011 Dec 1.

Institute of Health and Society, Université Catholique de Louvain (UCL),Clos-Chapelle-aux-Champs 30 bte 3015 Brussels, Belgium.

Background: The measurement of cough frequency is problematic and most often based on subjective assessment. The aim of the study was to assess the accuracy of the automatic identification of cough episodes by LR102, a cough frequency meter based on electromyography and audio sensors.

Methods: Ten adult patients complaining of cough were recruited in primary care and hospital settings. Read More

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http://dx.doi.org/10.1186/1745-9974-7-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268712PMC
December 2011
5 Reads

Posture influences patient cough rate, sedative requirement and comfort during bronchoscopy: An observational cohort study.

Cough 2011 Nov 10;7. Epub 2011 Nov 10.

Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

Objectives: To investigate differences between semi-recumbent and supine postures in terms of cough rate, oxygen desaturation, sedative use, and patient comfort during the initial phase of bronchoscopy.

Methods: Consecutive bronchoscopy patients (n = 69) participated in this observational cohort study. Posture was determined by the bronchoscopist's usual practice. Read More

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
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http://dx.doi.org/10.1186/1745-9974-7-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226548PMC
November 2011
10 Reads

Perspective on the human cough reflex.

Authors:
Stuart M Brooks

Cough 2011 Nov 10;7:10. Epub 2011 Nov 10.

Colleges of Public Health and Medicine, University of South Florida, Tampa, Florida.

This review dissects the complex human cough reflex and suggests hypotheses about the evolutionary basis for the reflex. A mechanosensory-induced cough reflex conveys through branches of myelinated Aδ nerve fibers is not chemically reactive (i.e. Read More

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http://dx.doi.org/10.1186/1745-9974-7-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234184PMC
November 2011
6 Reads

Cough response to isocapnic hyperpnoea of dry air and hypertonic saline are interrelated.

Cough 2011 Oct 14;7(1). Epub 2011 Oct 14.

Department of Respiratory Medicine, Kuopio University Hospital, P,O, Box 1777, 70211 Kuopio, Finland.

Background: Mechanisms behind asthmatic cough are largely unknown. It is known that hyperosmolar challenges provoke cough in asthmatic but not in the healthy subjects. It has been postulated that isocapnic hyperpnea of dry air (IHDA) and hypertonic aerosols act via similar mechanisms in asthma to cause bronchoconstriction. Read More

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http://dx.doi.org/10.1186/1745-9974-7-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205007PMC
October 2011
33 Reads