785,603 results match your criteria Cost Effectiveness and Resource Allocation[Journal]


The Influence of Antidepressants on the Disease Course Among Patients With Crohn's Disease and Ulcerative Colitis-A Danish Nationwide Register-Based Cohort Study.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

Background: Psychiatric comorbidity might modify the disease course adversely in patients with inflammatory bowel disease (IBD). Treatment options include antidepressants, which, apart from improving mood, have anti-inflammatory properties that might modify the disease course. This nationwide study aimed to examine the influence of antidepressants on the disease course among patients with ulcerative colitis (UC) and Crohn's disease (CD). Read More

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December 2018

Cost-Effectiveness of Chimeric Antigen Receptor T-Cell Therapy in Pediatric Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia.

J Natl Cancer Inst 2018 Dec 14. Epub 2018 Dec 14.

University of California San Diego School of Medicine, UCSD School of Medicine, La Jolla, CA.

Background: Chimeric antigen receptor T-cell (CAR-T) therapy is a promising new class of cancer therapy but has a high up-front cost. We evaluated the cost-effectiveness of CAR-T therapy among pediatric patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL).

Methods: We built a microsimulation model for pediatric patients with relapsed/refractory B-ALL receiving either CAR-T therapy or standard of care. Read More

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December 2018

'The phone is my boss and my helper' - A gender analysis of an mHealth intervention with Health Extension Workers in Southern Ethiopia.

J Public Health (Oxf) 2018 Dec;40(suppl_2):ii16-ii31

Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, UK.

Background: There is considerable optimism in mHealth's potential to overcome health system deficiencies, yet gender inequalities can weaken attempts to scale-up mHealth initiatives. We report on the gendered experiences of an mHealth intervention, in Southern Ethiopia, realised by the all-female cadre of Health Extension Workers (HEWs).

Methodology: Following the introduction of the mHealth intervention, in-depth interviews (n = 19) and focus group discussions (n = 8) with HEWs, supervisors and community leaders were undertaken to understand whether technology acted as an empowering tool for HEWs. Read More

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December 2018

Fabrication of ploydopamine-kaolin supported Ag nanoparticles as effective catalyst for rapid dye decoloration.

Chemosphere 2018 Dec 7;219:400-408. Epub 2018 Dec 7.

College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, 410082, PR China.

In this work, silver nanoparticles supported on polydopamine-kaolin composite (PDA-kaolin-Ag) was fabricated by an in-situ reduction method with PDA as both reductant and stabilizer. The morphology, composition, and structure of PDA-kaolin-Ag composite were characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The catalytic reduction tests confirmed the importance of PDA modification and high catalytic activities of this as-prepared PDA-kaolin-Ag composite towards a model dye Rhodamine B. Read More

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December 2018
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Stakeholder perspectives on implementing fentanyl drug checking: Results from a multi-site study.

Drug Alcohol Depend 2018 Nov 13;194:527-532. Epub 2018 Nov 13.

Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Hampton House 163, Baltimore, MD, USA.

Background: The opioid epidemic is one of the greatest public health crises of our times, driven increasingly by synthetic opioids such as fentanyl in the heroin supply. The implementation of drug checking in community settings has the potential to reduce the burden of fatal overdose, provide harm reduction education around safer drug consumption, and increase health access among people who use drugs (PWUD). To inform program development, we explored stakeholder opinions on drug checking technologies and implementation considerations. Read More

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November 2018

Biosensing methods for determination of creatinine: A review.

Biosens Bioelectron 2018 Nov 25;126:707-724. Epub 2018 Nov 25.

Department of Zoology, M.D. University, Rohtak 124001, India.

Creatinine is a metabolic product of creatine phosphate in muscles, which provides energy to muscle tissues. Creatinine has been considered as indicator of renal function specifically after dialysis, thyroid malfunction and muscle damage. The normal level of creatinine in the serum and its excretion through urine in apparently healthy individuals is 45-140 μM and 0. Read More

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November 2018

Rapid determination of 1,3-propanediol in fermentation process based on a novel surface-enhanced Raman scattering biosensor.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 28;211:227-233. Epub 2018 Nov 28.

Beijing Bioprocess Key Laboratory, Beijing University of Chemical Technology, Beijing 100029, PR China; College of Science, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:

The production of 1,3-propanediol (1,3-PDO) is an important fermentation process. However, 1,3-PDO could not be distinguished separately and efficiently in fermentations previously because it has a highly similar molecular structure to the feedstock glycerol (GLY) and by-product lactic acid (Lac), which leads to the difficulty of quantification. In this paper, a low-cost and environmentally friendly biosensor based on surface-enhanced Raman scattering (SERS) technique was developed. Read More

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November 2018

Human DNA degradation assessment and male DNA detection by quantitative-PCR followed by high-resolution melting analysis.

Forensic Sci Int 2018 Nov 29;295:1-7. Epub 2018 Nov 29.

Centro de Referencia en Identificación Genética Humana de la Universidad de Buenos Aires, Cátedra de Genética Forense y Servicio de Huellas Digitales Genéticas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, CP 1113, Ciudad Autónoma de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas-CONICET, Godoy Cruz 2290, CP 1425, Ciudad Autónoma de Buenos Aires, Argentina.

We developed a q-PCR technique that simultaneously evaluates the extent of degradation and determines the gender of a human DNA donor. QYDEG HRM is a triplex real-time PCR whose products are analysed by high-resolution melting (HRM). The system produces three amplicons: (1) transducin (beta)-like 1, Y-linked (TBL1Y) (84bp); (2) large-target sequence (DGlt) (244bp); and (3) small-target sequence (DGst) (152bp). Read More

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November 2018

Multivariate analysis and modeling of soil quality indicators in long-term management systems.

Sci Total Environ 2018 Dec 4;657:457-465. Epub 2018 Dec 4.

Department of Plant Production, São Paulo State University-UNESP, 14884-900 Jaboticabal, SP, Brazil. Electronic address:

Soil management systems, as well as the long-term application of nitrogen fertilization, might promote changes in soil quality (SQ). The knowledge of how agronomic practices influence SQ is the main factor in the development of most sustainable management systems. Thus, the aim of this study was to evaluate the influence of long-term management systems on SQ through the analysis of 10 soil quality indicators (SQIs), to select the most sensitive SQIs through principal components analysis (PCA) and to propose a mathematical model that could estimate the activities of enzymes based on SQI values with simple and low-cost procedures in relation to enzyme measurement. Read More

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December 2018

What factors influence ultra-processed food purchase and consumption in households with children? A comparison between participants and non-participants of the Supplemental Nutrition Assistance Program (SNAP).

Appetite 2018 Dec 11. Epub 2018 Dec 11.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Ultra-processed foods are industrially formulated products that are convenient, highly-palatable, and contain few whole ingredients. While popular among US households regardless of SES, these foods constitute a relatively large proportion of grocery spending among low-income households participating in the Supplemental Nutrition Assistance Program (SNAP). Little is understood about the perceived factors influencing selection and consumption of these foods, particularly among households with children participating in SNAP. Read More

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December 2018

Traditional attributes moo-ve over for some consumer segments: Relative ranking of fluid milk attributes.

Appetite 2018 Dec 11. Epub 2018 Dec 11.

Dept. of Agricultural Economics, Purdue University, 403 West State Street, West Lafayette, IN, 47907, USA.

Due to the decrease in fluid milk consumption as a beverage in the United States, the importance for dairy industry stakeholders to understand attribute preferences for consumer segments has increased. This paper uses a representative sample of U.S. Read More

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December 2018

A New Model to Predict Ischemic Stroke in Patients with Atrial Fibrillation Using Warfarin or Direct Oral Anticoagulants.

Heart Rhythm 2018 Dec 11. Epub 2018 Dec 11.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.

Background: Stroke risk stratification scores (e.g., CHADS-VASc) are used to tailor therapeutic recommendations for patients with atrial fibrillation (AF) in different risk groups. Read More

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December 2018

Dosimetric effects of the kV based image-guided radiation therapy of prone breast external beam radiation: Towards the optimized imaging frequency.

J Appl Clin Med Phys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Purpose: For prone breast treatment, daily image-guided radiation therapy (IGRT) allows couch shifting to correct breast position relative to the treatment field. This work investigates the dosimetric effect of reducing kV imaging frequencies and the feasibility of optimizing the frequency using patient anatomy or their first 3-day shifts.

Method: Thirty-seven prone breast patients who had been treated with skin marker alignment followed by daily kV were retrospectively analyzed. Read More

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December 2018
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Internet-based cognitive and behavioural therapies for post-traumatic stress disorder (PTSD) in adults.

Cochrane Database Syst Rev 2018 Dec 14;12:CD011710. Epub 2018 Dec 14.

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, Cardiff, UK, CF24 4HQ.

Background: Therapist-delivered trauma-focused psychological therapies are an effective treatment for post-traumatic stress disorder (PTSD). These have become the accepted first-line treatments for the disorder. Despite the established evidence-base for these therapies, they are not always widely available or accessible. Read More

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December 2018

Reversing wetland death from 35,000 cuts: Opportunities to restore Louisiana's dredged canals.

PLoS One 2018 14;13(12):e0207717. Epub 2018 Dec 14.

University of Central Florida, Orlando, Florida, United States of America.

We determined the number of permits for oil and gas activities in 14 coastal Louisiana parishes from 1900 to 2017, compared them to land loss on this coast, and estimated their restoration potential. A total of 76,247 oil and gas recovery wells were permitted, of which 35,163 (46%) were on land (as of 2010) and 27,483 of which are officially abandoned. There is a direct spatial and temporal relationship between the number of these permits and land loss, attributable to the above and belowground changes in hydrology resulting from the dredged material levees placed parallel to the canal (spoil banks). Read More

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December 2018
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Comparison of classical and transgenic genetic sexing strains of Mediterranean fruit fly (Diptera: Tephritidae) for application of the sterile insect technique.

PLoS One 2018 14;13(12):e0208880. Epub 2018 Dec 14.

Insect Pest Control Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna, Austria.

The development of genetic sexing strains (GSSs) based on classical genetic approaches has revolutionized the application of the sterile insect technique (SIT) against the Mediterranean fruit fly Ceratitis capitata (Wiedemann) (Diptera: Tephritidae). The global use of Mediterranean fruit fly GSS for SIT applications as part of area-wide integrated pest management (AW-IPM) programmes is testimony to their effectiveness. During recent years, transgenic sexing strains (TSSs) have been developed through genetic engineering techniques offering the possibility to produce male-only progeny by introducing female embryonic lethal genes and to increase the efficacy to identify released sterile males by means of the expression of fluorescent transgene markers. Read More

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December 2018

Correction: The cost-effectiveness of systematic screening for age-related macular degeneration in South Korea.

PLoS One 2018 14;13(12):e0209521. Epub 2018 Dec 14.

[This corrects the article DOI: 10.1371/journal.pone. Read More

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December 2018

Social identity mediates the positive effect of globalization on individual cooperation: Results from international experiments.

PLoS One 2018 14;13(12):e0206819. Epub 2018 Dec 14.

School of Psychology, University of New South Wales, Sydney, Australia.

Globalization is defined for individuals as their connectivity in global networks. Social identity is conceptualized as attachment and identification with a group. We measure individual involvement with global networks and local, national, and global social identity through a questionnaire. Read More

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December 2018

Economic impact of dengue in Mexico considering reported cases for 2012 to 2016.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006938. Epub 2018 Dec 14.

Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Background: Given that dengue disease is growing and may progress to dengue hemorrhagic fever (DHF), data on economic cost and disease burden are important. However, data for Mexico are limited.

Methodology/principal Findings: Burden of dengue fever (DF) and DHF in Mexico was assessed using official databases for epidemiological information, disabilities weights from Shepard et al, the reported number of cases and deaths, and costs. Read More

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December 2018

Determining diet from faeces: Selection of metabarcoding primers for the insectivore Pyrenean desman (Galemys pyrenaicus).

PLoS One 2018 14;13(12):e0208986. Epub 2018 Dec 14.

Department of Zoology and Animal Cell Biology, University of the Basque Country UPV/EHU, Leioa, Basque Country, Spain.

Molecular techniques allow non-invasive dietary studies from faeces, providing an invaluable tool to unveil ecological requirements of endangered or elusive species. They contribute to progress on important issues such as genomics, population genetics, dietary studies or reproductive analyses, essential knowledge for conservation biology. Nevertheless, these techniques require general methods to be tailored to the specific research objectives, as well as to substrate- and species-specific constraints. Read More

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December 2018

The relation of culture, socio-economics, and friendship to music preferences: A large-scale, cross-country study.

PLoS One 2018 14;13(12):e0208186. Epub 2018 Dec 14.

Institute of Computational Perception, Johannes Kepler University Linz, Linz, Austria.

Music listening is an inherently cultural behavior, which may be shaped by users' backgrounds and contextual characteristics. Due to geographical, socio-economic, linguistic, and cultural factors as well as friendship networks, users in different countries may have different music preferences. Investigating cultural-socio-economic factors that might be associated with between-country differences in music preferences can facilitate music information retrieval, contribute to the prediction of users' music preferences, and improve music recommendation in cross-country contexts. Read More

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December 2018

Impact of a Nutrition-Focused Quality Improvement Intervention on Hospital Length of Stay.

J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.

Clinical Nutrition, Sodexo Healthcare, Gaithersburg, Maryland (Ms Siegel and Mr Higgins); Department of Agricultural Economics, Mississippi State University, Starkville, Mississippi (Dr Fan); Catholic Heath Initiatives, Denver, Colorado (Ms Goldman); and Health Economics and Outcomes Research, Abbott Nutrition Research and Development, Columbus, Ohio (Drs Goates and Partridge).

Background: Despite its high prevalence, malnutrition in hospitalized patients often goes unrecognized and undertreated.

Local Problem: A hospital system sought to improve nutrition care by implementing a quality improvement initiative. Nurses screened patients upon admission using the Malnutrition Screening Tool and initiated oral nutrition supplements for patients at risk. Read More

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December 2018

Exploring the Delivery of Healthcare in the Police Detention Center Through Remote Presence Technology.

J Forensic Nurs 2018 Dec 13. Epub 2018 Dec 13.

Office of the Vice-President Research, University of Saskatchewan.

Introduction: There is overwhelming evidence to support the delivery of high-quality health service at a lower cost with the use of advanced technologies. Implementing remote presence technology to expand clinical care has been fraught with barriers that limit interprofessional collaboration and optimal client outcomes. In Canada, government ministries responsible for correctional services, policing, and health are well positioned to link federal, provincial, and regional services to enhance service delivery at the point of care for individuals detained within the justice system. Read More

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December 2018
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Comparison of Distraction Osteogenesis and Single-Stage Remodeling for Correction of Unilateral Coronal Craniosynostosis.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Division of Plastic and Reconstructive Surgery, Dalhousie University, Halifax.

Background: Unilateral coronal craniosynostosis is a challenging condition in craniofacial surgery. Frontoorbital advancement by single-stage resorbable remodeling and distraction osteogenesis (DO) techniques have known intraoperative differences, but their comparative outcomes are less well characterized.

Methods: A systematic literature search of the MEDLINE, EMBASE, LILACS, and Web of Science databases was conducted. Read More

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December 2018

Screening for Early Lung Cancer, Chronic Obstructive Pulmonary Disease, and Cardiovascular Disease (the Big-3) Using Low-dose Chest Computed Tomography: Current Evidence and Technical Considerations.

J Thorac Imaging 2018 Dec 13. Epub 2018 Dec 13.

Center for Medical Imaging North-East Netherlands (CMI-NEN), University Medical Center Groningen, University of Groningen.

Lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease are highly prevalent in the general population and expected to cause most deaths by 2050. For these "Big-3," treatment might cure, delay, or stop the progression of disease at a very early stage. Lung nodule growth rate (a biomarker for lung cancer), emphysema/air trapping (a biomarker for chronic obstructive pulmonary disease), and coronary artery calcification (a biomarker for cardiovascular disease) are imaging biomarkers of early stages of the Big-3 that can be acquired with low-dose computed tomography (CT). Read More

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December 2018

The impact of anti-vascular endothelial growth factor agents on visual impairment/blindness prevention in patients with diabetic macular edema and on associated patient and caregiver burden in Japan.

J Med Econ 2018 Dec 14:1-28. Epub 2018 Dec 14.

e Market Access, Health Economics and Outcomes Research , Bayer Yakuhin, Ltd , Tokyo , Japan.

Aims: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) and on associated patient and caregiver productivity loss in Japan.

Methods: We compared the impact of current care (estimated at 53.8% utilization of anti-VEGF agents using current data) with that of hypothetical care (characterized by a higher utilization of anti-VEGF agents [80. Read More

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December 2018
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Compliance with vaccination schedules.

Hum Vaccin Immunother 2018 Dec 14. Epub 2018 Dec 14.

a Medical School , European University , Cyprus.

Childhood immunization is amongst the most cost-effective public health interventions for reducing children's morbidity and mortality. Vaccination coverage is commonly used to assess the vaccination status of a community. Adherence to schedule is critical for providing maximum effectiveness against vaccine-preventable diseases in the community. Read More

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December 2018

Decrease in American birth rates makes it imperative for the United States to implement state mandated fertility coverage.

J Med Econ 2018 Dec 14:1-5. Epub 2018 Dec 14.

a McGill University Reproductive Center , 888 Boulevard de Maisonneuve East , Montréal , QC H2L 4S8 , Quebec , Canada.

In recent years, the prevalence of infertility has increased due to delayed child bearing and increase in the rate of male infertility. Given the high cost of fertility treatment, this option is not valid for families with low income, and those who can afford it usually choose to have multiple embryo transfers, which has led to an increase in multiple birth rates and increase in the cost of perinatal care. Due to the expected increase in infertility and decrease in the national live birth rate, the United States should set a plan to fund infertility treatment and lead a policy for single embryo transfer. Read More

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December 2018

Bone-targeted agent treatment patterns and the impact of bone metastases on patients with advanced breast cancer in the United States.

Curr Med Res Opin 2018 Dec 14:1-16. Epub 2018 Dec 14.

e Global Health Economics, Amgen Inc. , Thousand Oaks , CA , USA.

Objective: Bone metastases are common among patients with advanced breast cancer, putting patients at increased risk of skeletal-related events (SREs). This study described impact of bone metastases, utilization of bone-targeted agents (BTAs) and physicians' decision processes for BTA use in advanced breast cancer.

Methods: Data were collected using the Adelphi Breast Cancer Disease-Specific Programme in the United States. Read More

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December 2018
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A self-regulation perspective on how and when regulatory focus differentially relates to citizenship behaviors.

J Appl Psychol 2018 Dec 13. Epub 2018 Dec 13.

School of Business Administration.

Although previous research suggests that regulatory focus matters for organizational citizenship behaviors, it is unclear how promotion and prevention focus relate to such behaviors. Integrating regulatory focus theory with theories of self-regulation, we propose a conceptual model that links trait promotion and prevention foci with specific citizenship behaviors through an emotion-related self-regulation mechanism. Using a sample of 227 nurses working in a hospital context, we observed that trait promotion focus and trait prevention focus predict helping and voice via differential effects on emotional exhaustion. Read More

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December 2018

Irradiation-Induced Cobaloxime-Catalyzed C-H Monofluoroalkylation of Styrenes at Room Temperature.

Org Lett 2018 Dec 14. Epub 2018 Dec 14.

Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering , Hefei University of Technology , Hefei 230009 , P. R. China.

A cobaloxime-catalyzed photochemical synthesis of allyl monofluorides from styrenes is described herein. This method is characterized by mild reaction conditions, low-cost catalyst, and broad substrate scope. Furthermore, this convenient method will provide a facile synthesis toward novel monofluoroalkylated natural product and pharmaceutical derivatives. Read More

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December 2018

Cost implications for automaker compliance of Zero Emissions Vehicle requirements.

Environ Sci Technol 2018 Dec 14. Epub 2018 Dec 14.

While there are many automotive regulations in the United States, few studies in the literature examine the interaction between different rules. We investigate the cost implications of enforcing the national Corporate Average Fuel Economy (CAFE) and greenhouse gas (GHG) emissions standards and the Zero Emissions Vehicle (ZEV) requirements simultaneously. We construct a new "Cost Optimization Modeling for Efficiency Technologies" (COMET) to understand how vehicle manufacturers implement fuel economy technologies to comply with multiple regulations. Read More

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December 2018

[BABA of da Vinci robot thyroid surgery in the standard treatment of thyroid cancer surgery].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1071-1074

Departmeng of Thyroid and Breast Surgery, Jinan Military General Hospital, Jinan, 250031, China.

Thyroid cancer is the most common malignant tumor in endocrine surgery. Surgery is the first choice for most patients with thyroid cancer. Da Vinci robot system as the auxiliary system is the most advanced endoscopic surgery, largely to fill the cavity mirror device cannot bend, complex operation and so on insufficiency, has now become an important way of surgical treatment of thyroid cancer, and its curative effect, high safety, but because of the economic cost is higher, is currently not widespread popularity. Read More

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[Efficacy of SUPRA HFR in the treatment of acute renal damage during multiple myeloma].

G Ital Nefrol 2018 Dec;35(6)

S.C. Nefrologia, Dialisi e Trapianto U. AOU Città della Salute e della Scienza di Torino, Torino, Italia.

Acute Kidney Injury (AKI) is a frequent complication of multiple myeloma (MM) with unfavorable prognostic significance. Light chains removal, combined with hematological therapy (CT) seems to offer significant benefits to renal function recovery (RFR). The SUPRA HFR, through the combination of high cut-off membrane without albumin loss and adsorbent cartridge, represents one of the "emerging" light chain removal methods. Read More

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December 2018

[Robotic surgery : the future of prosthetic surgery ?]

Rev Med Suisse 2018 Dec;14(631):2238-2242

Service d'orthopédie et traumatologie de l'appareil moteur, HUG, 1211 Genève 14.

Indications for hip and knee replacement will continue to grow over the next few years. Robotic systems have been developed since the early 1990s in order to optimize implant positioning, to potentially improve clinical results, and to reduce perioperative morbidity. Currently, the different available systems certainly improve the accuracy and reproducibility of prosthetic components placement. Read More

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December 2018

How to Best Predict Fragility Fractures: An Update and Systematic Review.

Isr Med Assoc J 2018 Dec;20(12):773-779

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Because fragility fractures have an enormous impact on the practice of medicine and global health systems, effective screening is imperative. Currently, dual-energy X-ray absorptiometry (DXA), which has limited ability to predict fractures, is being used. We evaluated the current literature for a method that may constitute a better screening method to predict fragility fractures. Read More

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December 2018

[Leucocyte esterase as a reliable diagnostic, cost-effective and fast in knee infections].

Acta Ortop Mex 2018 Jul-Aug;32(4):198-202

Dirección de Educación e Investigación en Salud, Hospital de Traumatología. Unidad Médica de Alta Especialidad (UMAE). «Dr. Victorio de la Fuente Narváez», Instituto Mexicano del Seguro Social (IMSS). Ciudad de México. México.

Background: The articular infection represents a challenge due to its complexity and its devastating effect when not treated promptly. We have various diagnostic studies: cultures, ESR, CRP, count of leukocytes, among others but none is specific, it takes more than 30 minutes to complete and require complex infrastructure. In this study we determine the sensitivity and specificity of the leukocyte esterase for detection of an infectious process joint in Mexican population. Read More

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December 2018

Brief resolved unexplained events: Retrospective validation of diagnostic criteria and risk stratification.

Pediatr Pulmonol 2019 Jan;54(1):61-65

University of Insubria, Varese, Italy.

Background And Objectives: This study retrospectively evaluated the AAP guidelines for diagnosis and risk stratification of Brief Resolved Unexplained Events (BRUE) in a well-characterized cohort of infants admitted with an Apparent Life Threatening Event (ALTE). Further, using prospective follow-up, we endeavored to determine the safety of implementing ambulatory care for the lower risk BRUE population (LR-BRUE) and estimate the cost-savings of this practice.

Methods: Retrospective application of the BRUE criteria on infants younger than 12 months of age who had been admitted with an ALTE from 2006 to 2016 at a single tertiary care center in Lombardy, Italy. Read More

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January 2019

Molecule-Driven Nanoenergy Generator.

Small 2018 Dec 14:e1804146. Epub 2018 Dec 14.

School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.

A large potential can be generated when one end of 1D and/or 2D semiconducting nanostructures such as zinc oxide (ZnO) and molybdenum disulfide is exposed to a wide spectrum of chemical molecules. A nanoenergy generator that comprises vertically aligned ZnO nanowires and poly(vinyl chloride-co-vinyl-co-2-hydroxypropyl acrylate) is fabricated, and it can generate electricity from various molecules including gaseous species exhaled from human breath. The generated voltage, which depends sensitively on the molecular dipole moment of adsorbed chemical species and surface coverage, is significantly larger than the streaming or piezoelectric potentials and is powerful enough to directly drive a single carbon nanotube field-effect transistor. Read More

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December 2018

Survey on the status of teledermatology in Austria.

J Dtsch Dermatol Ges 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Graz Medical University, Graz, Austria.

Background: The use of digital communication media is becoming increasingly important, with the primary aim of improving both treatment quality and patients' quality of life. In an effort to optimize telemedicine in the field of dermatology, we conducted a survey among dermatologists in Austria.

Methods: Statistical analysis of a questionnaire that was developed by a working group and sent to 769 Austrian dermatologists. Read More

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December 2018

Incremental cost and length of stay associated with postprocedure delirium in transcatheter and surgical aortic valve replacement patients in the United States.

Catheter Cardiovasc Interv 2018 Dec 14. Epub 2018 Dec 14.

Edwards Lifesciences, Irvine, California.

Objectives: To explore the impact of post-procedure delirium on resource utilization following transcatheter and surgical aortic valve replacement (TAVR and SAVR, respectively).

Background: Postprocedure delirium is associated with worse long-term survival after TAVR and SAVR. However, its effect on resource utilization has been understudied. Read More

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December 2018

Tolerability and effectiveness of generic direct-acting antiviral drugs in eradication of hepatitis C genotype 4 among Egyptian patients.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University Cairo, Egypt.

Background: We investigated tolerability and effectiveness of generic, less expensive direct antiviral drugs in the treatment of hepatitis C virus genotype 4(HCV- GT-4) in an Egyptian cohort.

Patients And Methods: Retrospectively, we analyzed data from 648 patients with HCV-GT4 attending Alexandria Main University Hospital from January 2016 to May 2017 [488 treatment naïve/160 treatment experienced/288 with chronic hepatitis/360 with cirrhosis]. Patients received generic sofosbuvir/ledipasvir (n= 168, treatment naïve = 136, treatment-experienced = 32) or sofosbuvir/daclatasvir (n= 480, treatment naïve = 352, treatment-experienced = 128) ± ribavirin. Read More

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December 2018

Urinary circulating DNA and circulating antigen for diagnosis of schistosomiasis mansoni: a field study.

Trop Med Int Health 2018 Dec 14. Epub 2018 Dec 14.

Medical Biochemistry Department, Faculty of Medicine, University of Alexandria, Egypt.

Objective: To evaluate three non- invasive assays for the diagnosis of schistosomiasis mansoni in an Egyptian village.

Methods: Urine was collected for the detection of circulating cathodic antigen (CCA) and cell free parasite DNA (cfpd) by Point-of-contact (POC)-cassette assay and PCR respectively. These tests were compared to Kato Katz (KK) fecal thick smear for detection of Schistosoma mansoni eggs. Read More

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December 2018

In Situ Electrochemical Conversion of Ultrathin Tannin-NiFe Complex Film as an Efficient Oxygen-Evolving Electrocatalyst.

Angew Chem Int Ed Engl 2018 Dec 14. Epub 2018 Dec 14.

Tianjin University, Department of Chemistry, #92, Weijin Road, Nankai District, Department of Chemistry, School of Science, Tianjin University, 300072, Tianjin, CHINA.

Oxygen evolution reaction (OER) is an important half reaction in many energy conversion and storage techniques. However, the development of a low-cost easy-prepared OER electrocatalyst with high mass activity and rapid kinetics is still challenging. Here, we report the facile deposition of tannin-NiFe (TANF) complex film on carbon fiber paper (CP) as a highly efficient OER electrocatalyst. Read More

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December 2018

Quantitative multi-locus metabarcoding and waggle dance interpretation reveal honey bee spring foraging patterns in Midwest agroecosystems.

Mol Ecol 2018 Dec 14. Epub 2018 Dec 14.

Department of Entomology, The Ohio State University.

We explored the pollen foraging behavior of honey bee colonies situated in the corn and soybean dominated agroecosystems of central Ohio over a month-long period using both pollen metabarcoding and waggle dance inference of spatial foraging patterns. For molecular pollen analysis we developed simple and cost-effective laboratory and bioinformatics methods. Targeting four plant barcode loci (ITS2, rbcL, trnL and trnH), we implemented metabarcoding library preparation and dual-indexing protocols designed to minimize amplification biases and index mis-tagging events. Read More

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December 2018

Randomized phase II/III confirmatory treatment selection design with a change of survival end points: Statistical design of Radiation Therapy Oncology Group 1216.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: To confirm the treatment effects of concurrent cetuximab plus docetaxel observed in Radiation Therapy Oncology Group (RTOG) 0234 and single out the effect of cetuximab, we designed RTOG 1216, a randomized phase II/III study, which uses an intermediate end point to select the best regimen for definitive testing of survival benefit.

Methods: In phase II, the best regimen should demonstrate statistically significant efficacy against the control with predefined advantage over the competing arm regarding disease-free survival (DFS). We evaluate operating characteristics of the randomized II/III group sequential design through simulations and numerical integrations under the null and various alternative hypotheses. Read More

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December 2018

Single Slide Assessment - A highly effective cytological ROSE technique for EBUS and EUS guided FNA.

Cytopathology 2018 Dec 14. Epub 2018 Dec 14.

Department of Diagnostic and Molecular Pathology, Royal Cornwall Hospital, Truro, Cornwall, UK.

No standardised, comprehensive approach to Rapid On-Site Evaluation (ROSE) of cytology samples currently exists. Recent meta-analysis indicates variation in the effectiveness of ROSE [1], however, reviews commonly omit the details of how ROSE is conducted. This review demonstrates the clinical effectiveness of Single Slide Assessment (SSA) for ROSE of cytology samples, providing a highly effective, standardised methodology, maximising cell yield and the diagnostic potential of samples obtained via Endobronchial or Endoscopic ultrasound (EBUS/EUS). Read More

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December 2018

Incorporating Flexibility into Stiffness: Self-Grown Carbon Nanotubes in Melamine Sponges Enable A Lithium-Metal-Anode Capacity of 15 mA h cm Cyclable at 15 mA cm.

Adv Mater 2018 Dec 14:e1805654. Epub 2018 Dec 14.

Hefei National Research Center for Physical Science at the Microscale, CAS Key Laboratory of Materials for Energy Conversion & Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.

Although with an extremely high theoretical capacity (3860 mA h g ), the lithium (Li) metal anodes reported so far typically possess capacities of ≤5 mA h cm and cyclable at currents of ≤5 mA cm . In this work, a hierarchal carbon scaffold is designed with the self-growth of carbon nanotubes (CNTs) in nickel-decorated melamine sponges via thermal annealing. It is found that the nitrogen-doped carbon obtained from the melamine sponge, coupled with CNTs, provides an overall strong yet internally flexible host which enables an areal capacity of up to 15 mA h cm cyclable at a charging/discharging current of 15 mA cm as Li metal anodes. Read More

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December 2018

Changes in Australian practice patterns for glaucoma management.

Clin Exp Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

South Australian Institute of Ophthalmology, The University of Adelaide, South Australia, Australia.

Importance: The demand for glaucoma care is projected to increase significantly with the ageing population.

Background: To characterise trends in Australian practice patterns for glaucoma management over the 15-year period between 2003 and 2017.

Design: Retrospective audit. Read More

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December 2018
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Discovery of genomic regions and candidate genes controlling shelling percentage using QTL-seq approach in cultivated peanut (Arachis hypogaea L.).

Plant Biotechnol J 2018 Dec 13. Epub 2018 Dec 13.

Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, , Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan, 430062, China.

Cultivated peanut (Arachis hypogaea L.) is an important grain legume providing high-quality cooking oil, rich proteins and other nutrients. Shelling percentage (SP) is the 2 most important agronomic trait after pod yield and this trait significantly affects the economic value of peanut in the market. Read More

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December 2018
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