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    Selective separation and determination of glucocorticoids in cosmetics using dual-template magnetic molecularly imprinted polymers and HPLC.
    J Colloid Interface Sci 2017 May 17;504:124-133. Epub 2017 May 17.
    School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Colleges and Universities Key Laboratory of Utilization of Microbial and Botanical Resources, Nanning, Guangxi 530008, China.
    Molecularly imprinting polymers (MIPs) are typically prepared using a single template molecule, which allows selective separation and enrichment of only one target analyte. It is not suitable for determination of complex real samples containing multiple analytes. In order to expand the practical application of imprinted polymers, novel dual-template magnetic molecularly imprinted polymers (MMIPs) were synthesized by surface polymerization using hydrocortisone and dexamethasone as the dual-template molecules in this study. Read More

    Human colour in mate choice and competition.
    Philos Trans R Soc Lond B Biol Sci 2017 Jul;372(1724)
    Faculty of Psychology, Basel University, Basel 4055, Switzerland
    The colour of our skin and clothing affects how others perceive us and how we behave. Human skin colour varies conspicuously with genetic ancestry, but even subtle changes in skin colour due to diet, blood oxygenation and hormone levels influence social perceptions. In this review, we describe the theoretical and empirical frameworks in which human colour is researched. Read More

    Animal coloration research: why it matters.
    Philos Trans R Soc Lond B Biol Sci 2017 Jul;372(1724)
    School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia.
    While basic research on animal coloration is the theme of this special edition, here we highlight its applied significance for industry, innovation and society. Both the nanophotonic structures producing stunning optical effects and the colour perception mechanisms in animals are extremely diverse, having been honed over millions of years of evolution for many different purposes. Consequently, there is a wealth of opportunity for biomimetic and bioinspired applications of animal coloration research, spanning colour production, perception and function. Read More

    An overview of carboxymethyl derivatives of chitosan: Their use as biomaterials and drug delivery systems.
    Mater Sci Eng C Mater Biol Appl 2017 Aug 23;77:1349-1362. Epub 2017 Mar 23.
    School of Pharmaceutical Sciences, Department of Drugs and Medicines, UNESP-São Paulo State University, 14801-902 Araraquara, São Paulo, Brazil. Electronic address:
    Chitin is one of the most abundant natural polymers in the world and is used for the production of chitosan by deacetylation. Chitosan is nontoxic and biodegradable and, therefore, can be used as a biomaterial and for the construction of drug delivery systems. Nevertheless, the poor solubility of chitosan in neutral or alkalinized media has restricted its applications in the pharmaceutical and biomedical fields. Read More

    Methylparaben and butylparaben alter multipotent mesenchymal stem cell fates towards adipocyte lineage.
    Toxicol Appl Pharmacol 2017 May 17. Epub 2017 May 17.
    Department of Nutrition, The University of Tennessee, Knoxville, TN, United States. Electronic address:
    Paraben esters and their salts are widely used as preservatives in cosmetics, personal care products, pharmaceuticals, and foods. We previously reported that parabens promoted adipocyte differentiation in vitro and increased adiposity but suppressed serum marker of bone formation in vivo. Here, we investigated the effects of parabens (methylparaben and butylparaben) on modulating cell fate of multipotent stem cell line C3H10T1/2. Read More

    Chitosan/chondroitin sulfate hydrogels prepared in [Hmim][HSO4] ionic liquid.
    Carbohydr Polym 2017 Aug 25;170:99-106. Epub 2017 Apr 25.
    Polymers and Composite Materials Group (GMPC), Department of Chemistry, State University of Maringá (UEM), Av. Colombo 5790, CEP 87020-900 Maringá, Paraná, Brazil; Materials Science & Engineering Postgraduate Program (PPGCEM), Federal University of Technology-Paraná (UTFPR-LD), CEP 86036-370 Londrina-PR, Brazil; Biotechnology Postgraduate Program Applied to Agriculture, Paranaense University (UNIPAR), 87502-210 Umuarama-PR, Brazil.
    [Hmim][HSO4] ionic liquid (IL) and bio-renewable sources as chitosan (CHT) and chondroitin sulfate (CS) were used to yield hydrogel-based materials (CHT/CS). The use of IL to solubilize both polysaccharides was considered an innovative way based on "green chemistry" principle, aiming the production of CHT/CS blended systems. CHT/CS hydrogels were carried out in homogeneous medium from short dissolution times. Read More

    Synthesis of novel dibenzoxanthene derivatives and observation of apoptosis in human hepatocellular cancer cells.
    Bioorg Chem 2017 May 4;72:333-344. Epub 2017 May 4.
    College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China. Electronic address:
    We have synthesized dibenzoxanthene derivatives 2a-2i via nucleophilic substitution of methoxyl group and evaluated underlying antitumor molecular mechanism of target compounds. Compounds showed high cytotoxic activities against BEL-7402, A549, HeLa and MG-63 cancer cells in the µM range. These compounds inhibited the cell growth of BEL-7402 cells at S or G2/M phase. Read More

    Intermediate phases during solid to liquid transitions in long-chain n-alkanes.
    Phys Chem Chem Phys 2017 May 17. Epub 2017 May 17.
    Technische Thermodynamik, Universität Bremen, Badgasteiner Str. 1, 28359 Bremen, Germany and School of Engineering, University of Aberdeen, Aberdeen, AB24 3UE, Scotland, UK.
    The solid to liquid phase transition of n-alkanes with more than ten carbon atoms is an interesting phenomenon relevant to many fields, from cosmetics to automotive. Here we report Raman spectroscopy of tetradecane, pentadecane and hexadecane as a function of temperature. In order to gain information on the structural changes that the hydrocarbons undergo during melting, and to determine the temperature and the speed at which the phase change occurs, their temperature-dependent Raman spectra are acquired. Read More

    Review of Cranioplasty after Decompressive Craniectomy.
    Korean J Neurotrauma 2017 Apr 30;13(1):9-14. Epub 2017 Apr 30.
    Department of Neurosurgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea.
    Cranioplasty is an in evitable operation conducted after decompressive craniectomy (DC). The primary goals of cranioplasty after DC are to protect the brain, achieve a natural appearance and prevent sinking skin flap syndrome (or syndrome of the trephined). Furthermore, restoring patients' functional outcome and supplementing external defects helps patients improve their self-esteem. Read More

    METABOLISM AND DISPOSITION OF [(14)C]- Methycyclosiloxanes IN RATS.
    Toxicol Lett 2017 May 13. Epub 2017 May 13.
    Dow Corning Corporation, Midland, MI 48686, United States; ENVIRON International Corporation, Monroe, LA 71201, United States.
    Octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) are low molecular weight cyclic volatile methyl siloxanes (cVMSs) primarily used as intermediates or monomers in the production of high molecular weight silicone polymers. The use of D4 as a direct ingredient in personal care products has declined significantly over the past 10 years, although it may be present as a residual impurity in a variety of consumer products. D5 is still used as an intentional ingredient in cosmetics, consumer products and in dry cleaning. Read More

    Health-Related Quality of Life of Persons after Rhinoplasty: A Longitudinal Study among Iranian Population.
    J Clin Diagn Res 2017 Mar 1;11(3):ZC60-ZC62. Epub 2017 Mar 1.
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.
    Introduction: Despite the growing number of cosmetic rhinoplasty surgeries in Iran in recent years, there is little information about the effects of this procedure on the subjects' Quality of Life (QoL). This study examined the QoL after rhinoplasty in subjects without nasal obstruction, who wanted the surgery for aesthetic reasons, three and six months postoperatively.

    Aim: The aim of this study was to assess the changes of QoL in clients who take rhinoplasty. Read More

    Eyelid Malignancies- Always Quite Challenging.
    J Clin Diagn Res 2017 Mar 1;11(3):XR01-XR04. Epub 2017 Mar 1.
    Associate Professor, Department of General Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Pondicherry, India.
    The diagnosis and management of eyelid cancers are quite challenging. Eyelid tumours are relatively rare diverse group of diseases varied in their presentation and extent. Many benign tumours and inflammatory conditions quite frequently masquerade eyelid cancers. Read More

    Non-mix fragrances are top sensitizers in consecutive dermatitis patients - a cross-sectional study of the 26 EU-labelled fragrance allergens.
    Contact Dermatitis 2017 May 16. Epub 2017 May 16.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev-Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Background: For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of fragrance mix I (FM I) and fragrance mix II (FM II). Earlier reports have not included oxidized R-limonene [hydroperoxides of R-limonene (Lim-OOH)] and oxidized linalool [hydroperoxides of linalool (Lin-OOH)], and breakdown testing of FM I and FM II has mainly been performed in selected, mix-positive patients.

    Objectives: To report the prevalence of sensitization to the 26 fragrances, and to assess concomitant reactivity to FM I and/or FM II. Read More

    Design, synthesis and evaluation of anticancer activity of ruthenium (II) polypyridyl complexes.
    J Inorg Biochem 2017 May 10;173:93-104. Epub 2017 May 10.
    School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Guangdong Cosmetics Engineering & Technology Research Center, Guangzhou 51006, PR China. Electronic address:
    A new ligand PFPIP (PFPIP=2-(2,3,4,5,6-pentafluorophenyl)[4,5-f]imadazo [1,10]phenanthroline) and its four ruthenium(II) polypyridyl complexes [Ru(NN)2(PFPIP)](ClO4)2 (NN=dmb: 4,4'-dimethyl-2,2'-bipyridine, 1; bpy: 2,2'-bipyridine, 2; phen: 1,10-phenanthroline, 3; dmp: 2,9-dimethyl-1,10-phenanthroline, 4) were synthesized and characterized by elemental analysis, IR, (1)H NMR, (13)C NMR and ESI-MS. The cytotoxic activity in vitro of the ligand and complexes toward BEL-7402, A549, HeLa, HepG2 and MG-63 cell lines was evaluated using MTT method (MTT=(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). Complexes 1, 3 and 4 show moderate cytotoxic effect on the cell growth in BEL-7402 cells with IC50 values of 32. Read More

    Application of Hyperosmotic Nanoemulsions in Wound Healing: Partial Thickness Injury Model in Swine.
    Adv Wound Care (New Rochelle) 2017 May;6(5):153-165
    Weldon School of Biomedical Engineering, College of Engineering, Purdue University, West Lafayette, Indiana.
    Objective: In this work, we introduce a novel hyperosmotic nanoemulsion (HNE) topical agent for use in wound healing. These topical emulsion complexes combine a lipophilic thymol nanoemulsion with a hyperosmotic saccharide matrix. This combination has been previously shown to possess synergistic antimicrobial activity against a host of common and drug-resistant pathogens in vitro. Read More

    Behaviour of silver nanoparticles in simulated saliva and gastrointestinal fluids.
    Int J Pharm 2017 May 12. Epub 2017 May 12.
    National Institute of Public Health, Šrobárova 48, 100 42 Prague, Czech Republic.
    Continuously increasing application of silver nanoparticles (AgNPs) requires information on their safety and performance under biological conditions. Assessment of AgNPs in biological systems is also related to availability of robust toxicological methods for evaluation of toxic potential of AgNPs and information on their physicochemical state. Silver nanoparticles were subjected to action of simulated saliva, gastric and intestinal fluids, appropriately supplemented with digestive enzymes pepsin or pancreatin. Read More

    Single-staged uniportal VATS in the supine position for simultaneous bilateral primary spontaneous pneumothorax.
    J Cardiothorac Surg 2017 May 15;12(1):25. Epub 2017 May 15.
    Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul, 06591, Republic of Korea.
    Background: Simultaneous bilateral primary spontaneous pneumothorax (SBPSP) is rare, but requires surgery on both sides, in patients with definite bilateral bullae to prevent life-threatening conditions. Recently, uniportal video-assisted thoracoscopic surgery (VATS) has been widely accepted as a less invasive technique for the treatment of pneumothorax. Thus, we introduced single-staged uniportal VATS technique in the supine position, for the management of two cases of SBPSP. Read More

    Polyelectrolyte complexes based on alginate/tanfloc: Optimization, characterization and medical application.
    Int J Biol Macromol 2017 May 10;103:129-138. Epub 2017 May 10.
    Postgraduate Program in Environmental Engineering (PPGEA), Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil; Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil; Postgraduate Program in Materials Science & Engineering (PPGCEM), Federal University of Technology - Paraná (UTFPR-LD), CEP 86036-370 Londrina, PR, Brazil. Electronic address:
    Hydrogels based on alginate and tanfloc (a cationic biopolymer obtained from natural condensed tannins) were successfully prepared. Tanfloc (TN) presents high aqueous solubility at pHs lower than 10; it contains substituted amino sites and molar weight of ca. 600,000gmol(-1). Read More

    Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation.
    Biomolecules 2017 May 12;7(2). Epub 2017 May 12.
    Medena AG., Industriestrasse 16, CH-8910 Affoltern-am-Abis, Switzerland.
    Recently, aggressive advertisement claimed a "magic role" for plant stem cells in human skin rejuvenation. This review aims to shed light on the scientific background suggesting feasibility of using plant cells as a basis of anti-age cosmetics. When meristem cell cultures obtained from medicinal plants are exposed to appropriate elicitors/stressors (ultraviolet, ultrasound ultraviolet (UV), ultrasonic waves, microbial/insect metabolites, heavy metals, organic toxins, nutrient deprivation, etc. Read More

    The Potential of Triterpenoids from Loquat Leaves (Eriobotrya japonica) for Prevention and Treatment of Skin Disorder.
    Int J Mol Sci 2017 May 11;18(5). Epub 2017 May 11.
    Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
    The leaves of loquat (Eriobotrya japonica) possess high medicinal value and have been used as traditional medicines. However, there are no evidence-based studies on the skin-care effects of E. japonica leaves. Read More

    Factors affecting the course and severity of adult acne. Observational cohort study.
    J Dermatolog Treat 2017 May 10:1-21. Epub 2017 May 10.
    b Department of Quantitative Finance, Faculty of Economic Sciences , University of Warsaw , Warsaw , Poland.
    Objective: To identify factors improving symptoms and shortening duration of AA.

    Material And Methods: The observational cohort study was performed in 111 patients with AA (> 25 y.o. Read More

    Isoliquiritigenin Induces Cytotoxicity in PC-12 Cells In Vitro.
    Appl Biochem Biotechnol 2017 May 9. Epub 2017 May 9.
    School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China.
    Isoliquiritigenin (ISL) has been reported to have a wide range of biological activities. This study evaluated the cytotoxic effect of ISL on norvegicus pheochromocytoma cell line (PC-12 cells) and its possible molecular mechanism. The cytotoxicity in vitro of ISL against PC-12 cells was investigated by MTT assay. Read More

    Scaffolds based on chitosan/pectin thermosensitive hydrogels containing gold nanoparticles.
    Int J Biol Macromol 2017 May 6;102:1186-1194. Epub 2017 May 6.
    Postgraduate Program in Materials Science & Engineering, Federal University of Technology-Paraná (UTFPR-LD), CEP 86036-370 Londrina, Paraná, Brazil; Postgraduate Program in Environmental Engineering, Federal University of Technology-Paraná (UTFPR-AP), CEP 86812-460 Apucarana, Paraná, Brazil. Electronic address:
    Thermosensitive hydrogels based on chitosan/pectin (CS/Pec) and CS/Pec/gold nanoparticles (CS/Pec/AuNPs) were successfully prepared with different AuNP levels. Using a tilting method, gelation temperature was demonstrated to decrease when the amount of AuNPs increased and pectin concentrations decreased. The presence of AuNPs in the CS/Pec composite was evaluated via WAXS and UV-vis techniques, while SEM analysis assessed the average size of pores (350-600μm). Read More

    The effects of titanium dioxide nanoparticles on ultrastructure of zebrafish testis (Danio rerio).
    Micron 2017 Apr 26;100:38-44. Epub 2017 Apr 26.
    Sakarya University, Department of Biology, Serdivan, Sakarya, Turkey.
    Introduction: Nanotechnology investigates materials at nanoscale level (0.1-100nm in diameter). There are many commercially nanoproducts such as silver, silicon, titanium, zinc, and gold. Read More

    Nanotitania Exposure Causes Alterations in Physiological, Nutritional and Stress Responses in Tomato (Solanum lycopersicum).
    Front Plant Sci 2017 21;8:633. Epub 2017 Apr 21.
    Department of Biology, Western Kentucky University, Bowling GreenKY, USA.
    Titanium dioxide nanoparticles (nanotitania: TiO2NPs) are used in a wide range of consumer products, paints, sunscreens, and cosmetics. The increased applications lead to the subsequent release of nanomaterials in environment that could affect the plant productivity. However, few studies have been performed to determine the overall effects of TiO2NPs on edible crops. Read More

    Afr J Tradit Complement Altern Med 2017 1;14(3):128-135. Epub 2017 Mar 1.
    Department of Plant Protection, Faculty of Agriculture, University of Ahi Evran, Kırsehir-Turkey.
    Background: Salvia seeds are promite to dietary and healthy oils because they contain essential fatty acids. Salvia seeds frequently produce mucilage on soaking, and this mucilage is used for the treatment of eye diseases in eastern countries. Salvia species studied for medicine, food and cosmetics, have the potential to be used in the various fields. Read More

    Tyrosinase Inhibitory and Anti-oxidative Effects of Lactic Acid Bacteria Isolated from Dairy Cow Feces.
    Probiotics Antimicrob Proteins 2017 May 6. Epub 2017 May 6.
    Department of Microbiology, Pukyong National University, Busan, 48513, South Korea.
    Overproduction and accumulation of melanin cause a number of skin diseases. The inhibitors of tyrosinase are important for the treatment of skin diseases associated with hyper-pigmentation after UV exposure and application in cosmetics for whitening and depigmentation. Reactive oxygen species (ROS) including hydrogen peroxide are generated by chemical substances and metabolic intermediates and cause various diseases including cancer and heart diseases. Read More

    Acute and sub-chronic oral toxicity studies of erythritol in Beagle dogs.
    Food Chem Toxicol 2017 May 4;105:448-455. Epub 2017 May 4.
    Virbac Corporation, Ft. Worth, TX, USA.
    Polyols, also known as sugar alcohols, are widely used in the formulation of tooth-friendly and reduced-calorie foods. Considering the significant health benefits of polyols in products formulated for human use, there is increased interest in evaluating potential uses in companion animal applications. Erythritol and xylitol are two polyols which are currently widely used in products ranging from reduced-sugar foods to personal care and cosmetics. Read More

    Probing the threshold of membrane damage and cytotoxicity effects induced by silica nanoparticles in Escherichia coli bacteria.
    Adv Colloid Interface Sci 2017 Apr 28. Epub 2017 Apr 28.
    Univ. Bordeaux, CNRS, LOMA, UMR 5798, 351 cours de la Libération, 33400 Talence, France; Cellule de transfert NanoPhyNov, ADERA, LOMA, 351 cours de la Libération, 33400 Talence, France. Electronic address:
    The engineering of nanomaterials, because of their specific properties, is increasingly being developed for commercial purposes over the past decades, to enhance diagnosis, cosmetics properties as well as sensing efficiency. However, the understanding of their fate and thus their interactions at the cellular level with bio-organisms remains elusive. Here, we investigate the size- and charge-dependence of the damages induced by silica nanoparticles (SiO2-NPs) on Gram-negative Escherichia coli bacteria. Read More

    Salvia officinalis L. Essential Oil from Spain: Determination of Composition, Antioxidant Capacity, Antienzymatic and Antimicrobial Bioactivities.
    Chem Biodivers 2017 May 6. Epub 2017 May 6.
    GENZ-Group of research on Enzymology, Department of Biochemistry and Molecular Biology-A, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Spain.
    Four essential oils (EOs) from Salvia officinalis L. cultivated in Spain (Murcia province) were analyzed by gas chromatography coupled with mass spectrometry (GC/MS) to determine their relative and absolute composition. The main components were α-thujone (22. Read More

    Isolation of organic compounds with high added values from agro-industrial solid wastes.
    J Environ Manage 2017 May 2. Epub 2017 May 2.
    Institute of Chemical Engineering Sciences, Foundation for Research and Technology, Hellas (FORTH/ICE-HT), Stadiou Str., Platani, GR26504, Patras, Greece; Department of Chemical Engineering, University of Patras, GR 26504, Rion, Patras, Greece. Electronic address:
    Phenols are organic compounds with high antioxidant activity. Occurring mainly in plants, where they act as pigments or even as part of defense mechanisms against insects and herbivores. Given the positive impact on on human health, their isolation and purification from agricultural products is of particular interest for the production of nutritional, pharmaceutical and cosmetics supplements. Read More

    Ruthenium(II) polypyridyl complexes: Synthesis, characterization and anticancer activity studies on BEL-7402 cells.
    J Inorg Biochem 2017 Apr 27;173:1-11. Epub 2017 Apr 27.
    School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Guangdong Cosmetics Engineering & Technology Research Center, Guangzhou, 510006, PR China. Electronic address:
    Two new ligand PTTP (2-phenoxy-1,4,8,9-tetraazatriphenylene) and FTTP (2-(3-fluoronaphthalen-2-yloxy)-1,4,8,9-tetraazatriphenylene) and their six ruthenium(II) polypyridyl complexes [Ru(N-N)2(PTTP)](ClO4)2 and [Ru(N-N)2(FTTP)](ClO4)2 (N-N=dmb: 4,4'-dimethyl-2,2'-bipiridine; dmp: 2,9-dimethyl-1,10-phenanthroline; ttbpy: 4,4'-ditertiarybutyl-2,2'-bipyridine) were synthesized and characterized. The cytotoxic activity of the complexes against cancer cells HeLa, BEL-7402, A549, HepG-2, HOS and normal cell LO2 was evaluated by MTT method. The IC50 values range from 1. Read More

    The Use of Directional Reflectance Measurement for in vivo Assessment of Protective Properties of Cosmetics in the Infrared Radiation Range.
    Photochem Photobiol 2017 May 4. Epub 2017 May 4.
    Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Basic Biomedical Science, Kasztanowa Street 3, Sosnowiec, 41-200, Poland.
    Photoprotection of skin is now focused on UV radiation. The aim of this study was to evaluate in vivo cosmetic products in terms of protection against infrared radiation (IR) and propose a methodology for conducting such measurements. The directional reflectance (DR) of 12 UV filters, 6 care creams and 2 preparations containing fumed silica applied on the forearm of 36 volunteers was examined in six spectral bands for two angles of incidence. Read More

    Ex vivo human skin permeation of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI).
    Arch Toxicol 2017 May 3. Epub 2017 May 3.
    Institute for Work and Health (IST), University of Lausanne and Geneva, Lausanne, Switzerland.
    Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are biocides used in many types of products such as cosmetics, paints, and cleaning agents. Skin contact is often encountered when using these products. Although MCI and MI are strong allergens and cause skin irritation, no scientific skin permeation study has been reported except for some unpublished data. Read More

    The gene expression profile of a drug metabolism system and signal transduction pathways in the liver of mice treated with tert-butylhydroquinone or 3-(3'-tert-butyl-4'-hydroxyphenyl)propylthiosulfonate of sodium.
    PLoS One 2017 3;12(5):e0176939. Epub 2017 May 3.
    Institute of Molecular Biology and Biophysics, Novosibirsk, Russia.
    Tert-butylhydroquinone (tBHQ) is a highly effective phenolic antioxidant used in edible oils and fats in foods as well as in medicines and cosmetics. TBHQ has been shown to have both chemoprotective and carcinogenic effects. Furthermore, it has potential anti-inflammatory, antiatherogenic, and neuroprotective activities. Read More

    Objective breast symmetry analysis with the breast analyzing tool (BAT): improved tool for clinical trials.
    Breast Cancer Res Treat 2017 May 2. Epub 2017 May 2.
    Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
    Purpose: Objective cosmetic analysis is important to evaluate the cosmetic outcome after breast surgery or breast radiotherapy. For this purpose, we aimed to improve our recently developed objective scoring software, the Breast Analyzing Tool (BAT(®)).

    Methods: A questionnaire about important factors for breast symmetry was handed out to ten experts (surgeons) and eight non-experts (students). Read More

    Culture-independent detection of chlorhexidine resistance genes qacA/B and smr in bacterial DNA recovered from body sites treated with chlorhexidine-containing dressings.
    J Med Microbiol 2017 Apr;66(4):447-453
    2​Alliance for Vascular Access Teaching and Research, Griffith University, Brisbane, Australia 3​Inflammation and Healing Research Cluster, School of Health and Sports Sciences, University of the Sunshine Coast, Sippy Downs, Brisbane, Australia.
    Purpose: Dressings containing chlorhexidine gluconate (CHG) are increasingly used in clinical environments for prevention of infection at central venous catheter insertion sites. Increased tolerance to this biocide in staphylococci is primarily associated with the presence of qacA/B and smr genes.

    Methodology: We used a culture-independent method to assess the prevalence of these genes in 78 DNA specimens recovered from the skin of 43 patients at catheter insertion sites in the arm that were covered with CHG dressings. Read More

    Bactericidal mechanisms and effector targets of TiO2 and  Ag-TiO2 against Staphylococcus aureus.
    J Med Microbiol 2017 Apr;66(4):440-446
    3​Zhejiang-California International NanoSystems Institute, Zhejiang University, Hangzhou, PR China.
    Purpose: In our previous study, Ag+-loaded TiO2 and Ag+-loaded SiO2 coatings for tracheal intubation were prepared to prevent ventilator-associated pneumonia (VAP), but the antimicrobial targets and the underlying mechanisms of TiO2 and Ag-TiO2 (Ag+) are still unclear. We attempted to elucidate the antimicrobial activity and potential mechanisms against Staphylococcus aureus.

    Methodology: The study tested the TiO2 and Ag+ bacteriostatic activity against S. Read More

    Tyrosinase inhibitory activity, molecular docking studies and antioxidant potential of chemotypes of Lippia origanoides (Verbenaceae) essential oils.
    PLoS One 2017 1;12(5):e0175598. Epub 2017 May 1.
    Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Pará, Belém, Pará, Brazil.
    The essential oils (EOs) of the aerial parts of Lippia origanoides (LiOr), collected in different localities of the Amazon region, were obtained by hydrodistillation and analyzed by GC and CG-MS. Principle component analysis (PCA) based on chemical composition grouped the oils in four chemotypes rich in mono- and sesquiterpenoids. Group I was characterized by 1,8-cineole and α-terpineol (LiOr-1 and LiOr-4) and group II by thymol (LiOr-2). Read More

    One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation.
    Sci Rep 2017 Apr 28;7(1):1265. Epub 2017 Apr 28.
    ESPCI Paris, PSL Research University, CNRS UMR 7615, Laboratoire Sciences et Ingénierie de la Matière Molle, 10 rue Vauquelin, 75231, Paris, Cedex 05, France.
    Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibility and scaled up production. Here, we present a one-step method to produce in situ membranes at oil-water interfaces, based on the hydrogen bond complexation of polymers between H-bond acceptor and donor in the oil and aqueous phases, respectively. Read More

    Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin.
    Bioorg Med Chem 2017 Jun 18;25(12):2946-2955. Epub 2017 Apr 18.
    School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, China; Guangdong Cosmetics Engineering & Technology Research Center, Zhongshan 528458, China. Electronic address:
    By fusing donepezil and curcumin, a novel series of compounds were obtained as multitarget-directed ligands against Alzheimer's disease. Among them, compound 11b displayed potent acetylcholinesterase (AChE) inhibition (IC50=187nM) and the highest BuChE/AChE selectivity (66.3). Read More

    Benzyl alcohol induces a reversible fragmentation of the Golgi apparatus and inhibits membrane trafficking between endosomes and the trans-Golgi network.
    Exp Cell Res 2017 Apr 25. Epub 2017 Apr 25.
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway. Electronic address:
    Benzyl alcohol (BnOH) is widely used as a component of foods, cosmetics, household products and medical products. It is generally considered to be safe for human use, however, it has been connected to a number of adverse effects, including hypersensitivity reactions and neonatal deaths. BnOH is a membrane fluidizing agent that can affect membrane protein activity and cellular processes such as ligand binding to cell surface receptors, endocytosis and degradation of lysosomal cargo. Read More

    Formulation, Characterization and Properties of Hemp Seed Oil and Its Emulsions.
    Molecules 2017 Apr 27;22(5). Epub 2017 Apr 27.
    Department of Environmental Protection and Engineering, Faculty of Technology, Tomas Bata University in Zlin, nam. T. G. Masaryka 5555, 760 01 Zlin, Czech Republic.
    The formulation, characterization, and anticipated antibacterial properties of hemp seed oil and its emulsions were investigated. The oil obtained from the seeds of Cannabis sativa L. in refined and unrefined form was characterized using iodine, saponification, acid values, and gas chromatography, and was employed for the preparation of stable oil-in-water emulsions. Read More

    How people used ochre at Rose Cottage Cave, South Africa: Sixty thousand years of evidence from the Middle Stone Age.
    PLoS One 2017 26;12(4):e0176317. Epub 2017 Apr 26.
    Evolutionary Studies Institute, University of the Witwatersrand, Johannesburg, South Africa.
    We describe colour, hardness, grain size, geological type and surface modifications of ochre pieces excavated, first by Malan and later by Harper, from the Middle Stone Age (MSA) of Rose Cottage Cave, 96, 000 to 30, 000 years ago. Soft, bright-red shales are abundant, and most ochre has clayey or silty grain sizes. The post-Howiesons Poort layers contain the most ochre pieces, but the Howiesons Poort layers have the highest frequency of ochre per sediment volume. Read More

    The Influence of Hydroxyapatite Nanoparticle Morphology on Embryonic Development in a Zebrafish Exposure Model.
    Nanomaterials (Basel) 2017 Apr 22;7(4). Epub 2017 Apr 22.
    Department of Engineering Science, Applied Materials Science, Uppsala University, 75106 Uppsala, Sweden.
    Nanomaterials are used in many different industries such as cosmetics, food, clothing, and electronics. There is increasing concern that exposure to nanoparticles (NPs) during pregnancy can adversely affect fetal development. It is well known that the size, charge, and chemistry of a nanoparticle can modulate embryological development. Read More

    Microplastics in a freshwater environment receiving treated wastewater effluent.
    Integr Environ Assess Manag 2017 May;13(3):528-532
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, USA.
    Small plastic fragments (microplastics or solid particles <5 mm in size or "microbeads" used in personal care products and cosmetics) may ultimately find their way into aquatic environments. We studied the presence of microplastics (particle sizes 53-105 μm and 106-179 μm) spatially and temporally in 3 connected urban lakes being fed by treated wastewater effluent in Lubbock, Texas. These lakes also serve as drainage during storm events. Read More

    Different toxicity of anatase and rutile TiO2 nanoparticles on macrophages: Involvement of difference in affinity to proteins and phospholipids.
    J Hazard Mater 2017 Aug 9;335:125-134. Epub 2017 Apr 9.
    Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China. Electronic address:
    TiO2 nanoparticles (NPs) are well-known nanomaterials (NMs), widely used in cosmetics, solar cells, photo-catalysts and additives. Anatase and rutile are the two main crystalline phases of TiO2 NPs and have distinct electrical and optical properties. However, their relative toxicity to organisms is a current topic of debate. Read More

    Development of oral lyophilisates containing meloxicam nanocrystals using QbD approach.
    Eur J Pharm Sci 2017 Apr 20;104:356-365. Epub 2017 Apr 20.
    Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eotvos u. 6, Szeged H-6720, Hungary. Electronic address:
    The aim of this study was to develop oral lyophilisates with improved meloxicam (MEL) dissolution, optimizing each step of the preparation by design of experiments. First, meloxicam nanosuspensions were prepared by high-pressure homogenization (HPH), using PVP, Poloxamer or PEG as stabilizers and were subjected to freeze-drying using mannitol as cryoprotectant. The effects of the stabilizers and cryoprotectant were assessed and an optimal formulation was generated within the Design Space where the particle sizes and the PDIs are at their lowest values. Read More

    Assessing seasonal variation of synthetic musks in beach sands from Oporto coastal area: A case study.
    Environ Pollut 2017 Apr 18;226:190-197. Epub 2017 Apr 18.
    LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
    Synthetic musk compounds are widely used in the formulation of several cosmetics, personal care and household products. Due to their massive and widespread use, together with some health concerns, they are considered emerging pollutants and have been detected in different environmental compartments. This study focused on the evaluation of the concentration of synthetic musks (five nitro, five polycyclic and one macrocyclic musks) in beach sands, from Oporto coastal area (Portugal), contributing to the enhancement of the knowledge of levels, trends and behaviour of these compounds in this particular matrix. Read More

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