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    Therapeutic herbs confirmed by evidence-based medicine.
    Clin Dermatol 2018 May - Jun;36(3):289-298. Epub 2018 Mar 10.
    Private practice, Fruitland, ID. Electronic address:
    Mucocutaneous diseases and conditions, including aging, are known to be the result of multiple pathophysiologic anomalies induced by various environmental insults. Creating therapeutic products for these multifactorial diseases and conditions is challenging. Although safety testing is not required for cosmetics and cosmeceuticals, consumer expectation is for products to be effective and well tolerated while maintaining cosmetic elegance. Read More

    Production of the compatible solute α-D-glucosylglycerol by metabolically engineered Corynebacterium glutamicum.
    Microb Cell Fact 2018 Jun 16;17(1):94. Epub 2018 Jun 16.
    Institute of Biochemistry, University of Cologne, Zülpicher Str. 47, 50674, Cologne, Germany.
    Background: α-D-Glucosylglycerol (αGG) has beneficial functions as a moisturizing agent in cosmetics and potential as a health food material, and therapeutic agent. αGG serves as compatible solute in various halotolerant cyanobacteria such as Synechocystis sp. PCC 6803, which synthesizes αGG in a two-step reaction: The enzymatic condensation of ADP-glucose and glycerol 3-phosphate by GG-phosphate synthase (GGPS) is followed by the dephosphorylation of the intermediate by the GG-phosphate phosphatase (GGPP). Read More

    Integrated study of the mechanism of tyrosinase inhibition by baicalein using kinetic, multispectroscopic and computational simulation analyses.
    Int J Biol Macromol 2018 Jun 13. Epub 2018 Jun 13.
    Department of Pharmaceutical and Biological Engineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, China. Electronic address:
    Controlling the activity of tyrosinase, which plays an important role in melanin synthesis, is essential endeavor in the field of medicine, food, cosmetics, and agriculture. Baicalein is a widely available inhibitor of tyrosinase. The mechanism of this inhibition was studied through an integrated approach coupling enzyme kinetics, multiple types of spectroscopy and computational simulation. Read More

    Gromwell (Lithospermum erythrorhizon) root extract protects against glycation and related inflammatory and oxidative stress while offering UV absorption capability.
    Exp Dermatol 2018 Jun 15. Epub 2018 Jun 15.
    Amway Corporation, Research& Development, 7575 Fulton Street, Ada, MI, 49355, USA.
    Glycation and advanced glycation endproducts (AGE) damage skin which is compounded by AGE-induced oxidative stress and inflammation. Lip and facial skin could be susceptible to glycation damage as they are chronically stressed. As Gromwell (Lithospermum erythrorhizon) root (GR) has an extensive traditional medicine history that includes providing multiple skin benefits, our objective was to determine if GR extract and its base naphthoquinone, shikonin, might protect skin by inhibiting glycation, increasing oxidative defenses, suppressing inflammatory responses, and offering ultraviolet (UV) absorptive potential in lip and facial cosmetic matrices. Read More

    [Rapid screening of three halogenated salicylanilines in cosmetics using ambient ionization coupled with ion mobility spectrometry].
    Wei Sheng Yan Jiu 2017 May;46(3):467-471
    Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
    Objective: A rapid analytical method had been developed for the screening of three halogenated salicylanilines in cosmetics using ambition ionization coupled with ion mobility spectrometry.

    Methods: Without time-consuming pretreatment, cosmetic samples of lotion, lipstick and powder were added or smudged onto a Grade 3MM chromatography paper for paper spray ionization, cosmetic samples of cream and shampoo were simply loaded with a metal wire probe for extraction nano-electrospray.

    Results: The limits of detection( LODs) for the three halogenated salicylanilides were 50 μg/kg. Read More

    [Isolation of polyethylene microbeads in cosmetics by double-density separation].
    Wei Sheng Yan Jiu 2017 Nov;46(6):986-990
    National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
    Objective: To develop a stable method for isolation and quantitation of polyethylene microbeads in cosmetics and to observe its morphology and size.

    Methods: Polyethylene microbeads were isolated by using the difference of relative density between polyethylene and two kinds of separation solutions( sodium chloride solution and acetonitrile). The contents of polyethylene microbeads in cosmetics were determined by gravimetric method. Read More

    A versatile method for the selective core-crosslinking of hyaluronic acid nanogels via ketone-hydrazide chemistry: from chemical characterization to in vivo biodistribution.
    Biomater Sci 2018 Jun 14. Epub 2018 Jun 14.
    Grenoble Alpes University, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), 601, rue de la Chimie, BP 53, 38041 Grenoble Cedex 9, France.
    The development of biopolymer-based nanogels has gained particular interest to achieve successful delivery of therapeutics for the treatment of various diseases, such as cancer, infection and diabetes. Herein, we report a new and simple methodology for the covalent stabilization of self-assembled gel nanoparticles based on hyaluronic acid (HA) modified with a thermoresponsive ketone-functional copolymer. This relies on the selective formation of hydrazone crosslinks with bishydrazides within the globular domains of the copolymer chains formed above the cloud point temperature. Read More

    Adaptation of the human Cell Line Activation Test (h-CLAT) to Animal-Product-Free Conditions.
    ALTEX 2018 Jun 13. Epub 2018 Jun 13.
    XCellR8 Ltd, The Innovation Centre, Sci-Tech Daresbury, Daresbury, Cheshire, UK.
    Skin sensitisers are substances that can elicit allergic responses following skin contact and the process by which this occurs is described as skin sensitisation. Skin sensitisation is defined as a series of key events, that form an adverse outcome pathway (AOP). Key event three in the AOP is dendritic cell activation that can be modelled by the human Cell Line Activation Test (h-CLAT) and is typified by changes in cell surface markers CD54 and CD86 in dendritic cells. Read More

    Innovative Natural Ingredients-Based Multiple Emulsions: The Effect on Human Skin Moisture, Sebum Content, Pore Size and Pigmentation.
    Molecules 2018 Jun 12;23(6). Epub 2018 Jun 12.
    Institute of Pharmaceutical Technology, Lithuanian University of Health Sciences, Medical Academy, Sukileliu pr. 13, LT-50162 Kaunas, Lithuania.
    The increased interest in natural cosmetics has resulted in a higher market demand for preservative-free products based on herbal ingredients. An innovative W/O/W type emulsions containing herbal extracts were prepared directly; its cation form was induced by an ethanolic rosemary extract and stabilized using weak herbal gels. Due to the wide phytochemical composition of herbal extracts and the presence of alcohol in the emulsion system, which can cause skin irritation, sensitization or dryness when applied topically, the safety of the investigated drug delivery system is necessary. Read More

    Application of mesocellular siliceous foams (MCF) for surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) Analysis of fingermarks.
    Sci Justice 2018 Jul 26;58(4):264-270. Epub 2018 Mar 26.
    Embrapa Recursos Genéticos e Biotecnologia, Laboratório de Nanobiotecnologia (LNANO), Brasília 70770-917, DF, Brazil; Universidade de Brasília, Instituto de Ciências Biológicas, Programa de Pós-graduação em Nanociência e Nanobiotecnologia, Brasília 70910-900, DF, Brazil. Electronic address:
    Recent advances in nanotechnology applied in forensic sciences have contributed to consider new approaches including chemical evaluation of latent fingermarks. Significant improvement to the detection of small organic molecules has been reached with matrix-free methods associated to laser desorption/ionization mass spectrometry. The present study investigated the application of mesocellular siliceous foam (MCF) as an ionizing agent for laser desorption/ionization (LDI-MS) analysis of fingermarks as a proof of concept research. Read More

    Identification of Isolated from Cosmetic Samples Using MALDI-TOF MS and 16S rRNA Sequencing Methods.
    J AOAC Int 2018 Jun 12. Epub 2018 Jun 12.
    U.S. Food and Drug Administration, Office of Regulatory Affairs, Office of Regulatory Science, Microbiological Sciences Branch, Southeast Food and Feed Laboratory, 60 8th St NE, Atlanta, GA 30309.
    is a Gram-positive, rod-shaped bacterium that can cause tropical ulcers, severe sepsis, and respiratory illnesses in humans. In this study, we analyzed cosmetic samples for the presence of human pathogenic microorganisms. Five unopened jars of exfoliating cream were examined initially by microbiological methods. Read More

    Aggregate consumer exposure to isothiazolinones via household care and personal care products: Probabilistic modelling and benzisothiazolinone risk assessment.
    Environ Int 2018 Jun 9;118:245-256. Epub 2018 Jun 9.
    Institute for Chemical and Bioengineering, ETH Zürich, Zürich, Switzerland.
    Consumers regularly use household care and personal care products (HC&PCPs). Isothiazolinones are included in HC&PCPs as preservatives and are being held responsible for an epidemic rise in allergic contact dermatitis (ACD). The objective of this study was to assess the origin and extent of dermal exposure in order to evaluate the risk of ACD from isothiazolinones in HC&PCP. Read More

    Biomolecules-mediated synthesis of selenium nanoparticles using Aspergillus oryzae fermented Lupin extract and gamma radiation for hindering the growth of some multidrug-resistant bacteria and pathogenic fungi.
    Microb Pathog 2018 Jun 9;122:108-116. Epub 2018 Jun 9.
    Drug Microbiology Lab., Drug Radiation Research Dep., Biotechnology Division, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
    Biosynthesis of nanoparticles by fermented plants using microbes is an eco-friendly and cost-effective process. In this study, we used the fungus Aspergillus orayzae for the fermentation process. The aqueous extract of fermented Lupin (AEFL) possesses the ability to reduce selenium ion in the presence of gamma rays evidenced by the color changes to red. Read More

    Silicon dioxide nanoparticles induce COX-2 expression through activation of STAT3 signaling pathway in HaCaT cells.
    Toxicol In Vitro 2018 Jun 9. Epub 2018 Jun 9.
    College of Pharmacy, Keimyung University, Daegu 704-701, South Korea. Electronic address:
    Silicon dioxide nanoparticles (SiO-NPs) are widely used in biomedicines and consumer products, such as sunscreens and cosmetics. However, SiO-NPs can cause adverse effects on human health, depending on the size and concentration of nanoparticles. The present study was aimed at investigating the molecular mechanism underlying SiO-NPs-induced inflammation in human keratinocyte (HaCaT) cells. Read More

    Structure⁻Activity Relationship of the Tyrosinase Inhibitors Kuwanon G, Mulberrofuran G, and Albanol B from Species: A Kinetics and Molecular Docking Study.
    Molecules 2018 Jun 11;23(6). Epub 2018 Jun 11.
    Department of Food and Life Science, Pukyong National University, Busan 48513, Korea.
    Kuwanon G (KG) and benzofuran flavonoids such as mulberrofuran G (MG) and albanol B (AB) isolated from sp. are reported to exhibit anti-Alzheimer’s disease, anti-inflammatory, fungicidal, anti-cancer, anti-bacterial, and anti-tyrosinase properties. We investigated the inhibition of mono- and diphenolase activity of mushroom tyrosinase by KG, MG, and AB. Read More

    Exploring the Valuable Carotenoids for the Large-Scale Production by Marine Microorganisms.
    Mar Drugs 2018 Jun 8;16(6). Epub 2018 Jun 8.
    Department of Agrochemistry and Biochemistry, Biochemistry and Molecular Biology division, Faculty of Science, University of Alicante, Ap. 99, E-03080 Alicante, Spain.
    Carotenoids are among the most abundant natural pigments available in nature. These pigments have received considerable attention because of their biotechnological applications and, more importantly, due to their potential beneficial uses in human healthcare, food processing, pharmaceuticals and cosmetics. These bioactive compounds are in high demand throughout the world; Europe and the USA are the markets where the demand for carotenoids is the highest. Read More

    Screening study of four environmentally relevant microplastic pollutants: Uptake and effects on Daphnia magna and Artemia franciscana.
    Chemosphere 2018 Jun 8;208:522-529. Epub 2018 Jun 8.
    Faculty of Chemistry and Chemical Technology, Chair of Materials and Polymer Science, Večna pot 113, 1000, Ljubljana, Slovenia.
    This study investigated four different environmentally relevant microplastic (MP) pollutants which were derived from two facial cleansers, a plastic bag and polyethylene textile fleece. The mean size range of the particles (according to number distribution) was 20-250 μm when measured as a powder and 0.02-200 μm in suspension. Read More

    Allergic contact dermatitis caused by acrylic-based medical dressings and adhesives.
    Contact Dermatitis 2018 Jun 11. Epub 2018 Jun 11.
    Department of Dermatology, University Hospitals KU Leuven, Leuven, Belgium.
    Background: Acrylates and methacrylates are acrylic resin monomers that are known to induce skin sensitization as a result of their presence in different materials, such as nail cosmetics, dental materials, printing inks, and adhesives. Allergic contact dermatitis resulting from the use of modern wound dressings containing them has only rarely been reported.

    Objectives: To describe 2 patients who developed allergic contact dermatitis caused by acrylic-based modern medical dressings and/or adhesives. Read More

    Analytical Methods for the Determination of Mineral Oil Saturated Hydrocarbons (MOSH) and Mineral Oil Aromatic Hydrocarbons (MOAH)-A Short Review.
    Anal Chem Insights 2018 4;13:1177390118777757. Epub 2018 Jun 4.
    Chemisches und Veterinäruntersuchungsamt (CVUA) Karlsruhe, Karlsruhe, Germany.
    Mineral oils (such as paraffinum liquidum or white oil), which consist of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH), are widely applied in various consumer products such as medicines and cosmetics. Contamination of food with mineral oil may occur by migration of mineral oil containing products from packaging materials, or during the food production process, as well as by environmental contamination during agricultural production. Considerable analytical interest was initiated by the potential adverse health effects, especially carcinogenic effects of some aromatic hydrocarbons. Read More

    Removal of azo dye using Fenton and Fenton-like processes: Evaluation of process factors by Box-Behnken design and ecotoxicity tests.
    Chem Biol Interact 2018 Jun 6;291:47-54. Epub 2018 Jun 6.
    Laboratory of Nanosystems and Drug Delivery Systems (NanoSYS), Faculty of Pharmacy, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil. Electronic address:
    The conventional treatment of textile effluents is usually inefficient in removing azo dyes and can even generate more toxic products than the original dyes. The aim of the present study was to optimize the process factors in the degradation of Disperse Red 343 by Fenton and Fenton-like processes, as well as to investigate the ecotoxicity of the samples treated under optimized conditions. A Box-Behnken design integrated with the desirability function was used to optimize dye degradation, the amount of residual HO [HO], and the ecotoxicity of the treated samples (lettuce seed, Artemia salina, and zebrafish in their early-life stages). Read More

    Bioengineering of a Full-Thickness Skin Equivalent in a 96-Well Insert Format for Substance Permeation Studies and Organ-On-A-Chip Applications.
    Bioengineering (Basel) 2018 Jun 7;5(2). Epub 2018 Jun 7.
    Institute of Biotechnology, Department Medical Biotechnology, Technische Universität Berlin, D-13355 Berlin, Germany.
    The human skin is involved in protecting the inner body from constant exposure to outer environmental stimuli. There is an evident need to screen for toxicity and the efficacy of drugs and cosmetics applied to the skin. To date, animal studies are still the standard method for substance testing, although they are currently controversially discussed Therefore, the multi-organ chip is an attractive alternative to replace animal testing. Read More

    Muscle differentiation induced up-regulation of calcium-related gene expression in quail myoblasts.
    Asian-Australas J Anim Sci 2018 May 31. Epub 2018 May 31.
    Seoul National University, Pyeongchang-gun, Gangwon-do, Korea.
    Objective: In the poultry industry, the most important economic traits are meat quality and carcass yield. Thus, many studies were conducted to investigate the regulatory pathways during muscle differentiation. To gain insight of muscle differentiation mechanism during growth period, we identified and validated calcium-related genes which were highly expressed during muscle differentiation through mRNA sequencing analysis. Read More

    Determination of N-nitrosamines in cosmetic products by vortex-assisted reversed-phase dispersive liquid-liquid microextraction and LC-MS.
    J Sep Sci 2018 Jun 7. Epub 2018 Jun 7.
    Department of Analytical Chemistry, University of Valencia, Burjassot, Spain.
    A new analytical method for the simultaneous determination of trace levels of seven prohibited N-nitrosamines (N-nitrosodimethylamine, N-nitrosoethylmethylamine, N-nitrosopyrrolidine, N-nitrosodiethylamine, N-nitrosopiperidine, N-nitrosomorpholine, and N-nitrosodiethanolamine) in cosmetic products has been developed. The method is based on vortex-assisted reversed-phase dispersive liquid-liquid microextraction, which allows the extraction of highly polar compounds, followed by liquid chromatography with mass spectrometry. The variables involved in the extraction process were studied to obtain the highest enrichment factor. Read More

    Nano-cellulose based nano-coating biomaterial dataset using corn leaf biomass: An innovative biodegradable plant biomaterial.
    Data Brief 2018 Apr 5;17:162-168. Epub 2018 Jan 5.
    Program of Biotechnology, Department of Biology, Faculty of Science, University of Hail, Hail 2440, Saudi Arabia.
    The nanocellulose derived biodegradable plant biomaterial as nano-coating can be used in the medical, biomedical cosmetics, and bioengineering products. Bio-plastic and some synthetic derived materials are edible and naturally biodegradable. The study was conducted to investigate edible nano-biopolymer based nano-coating of capsules and drugs or other definite biomedical materials from corn leaf biomass. Read More

    Effect of pH on Bactericidal Activities of Calcium Laurate.
    J Oleo Sci 2018 Jun 7. Epub 2018 Jun 7.
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University.
    Fatty acid calcium salt is a high melting point powder excellent in lubricity and water repellency and is often used as a cosmetic raw material. We have shown that several calcium salts of fatty acids have high selective bactericidal activity against Staphylococcus aureus and Propionibacterium acnes and low bactericidal activity against Staphylococcus epidermidis. In this study, we evaluated the influence of pH on the bactericidal behavior of calcium laurate, and showed that under acidic conditions it shows higher bactericidal activity against both bacteria but selectivity becomes lower. Read More

    Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts).
    Mutat Res 2018 Jul 4;831:19-23. Epub 2018 May 4.
    Department of Genetics and Biotechnology (DGB - ECVA), University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, P-5001-801 Vila Real, Portugal; Animal and Veterinary Research Center (CECAV), University of Trás-os-Montes and Alto Douro, Quinta de Prados, Vila Real, Portugal. Electronic address:
    Titanium dioxide nanoparticles (TiONP) are used in the food, drug, and cosmetics industries and evaluation of their human and environmental toxicity is required. We have tested the toxicity of TiONP (anatase) with respect to developmental effects and DNA damage in Drosophila melanogaster strain Ok, using the eye-spot Somatic Mutation and Recombination Test (SMART) and the comet assay (neuroblasts). For the survival assay, TiONP were supplied to adult flies for 72 h and no adverse effects were seen. Read More

    Highly structured genetic diversity of Bixa orellana var. urucurana, the wild ancestor of annatto, in Brazilian Amazonia.
    PLoS One 2018 6;13(6):e0198593. Epub 2018 Jun 6.
    Departamento de Genética, Escola Superior de Agricultura "Luiz de Queiroz", Universidade de São Paulo (ESALQ-USP), Piracicaba, São Paulo, Brasil.
    Annatto (Bixa orellana L.) is a tropical American crop, commercially valuable due to its application in the food and cosmetics industries as a natural dye. The wild ancestor of cultivated annatto is B. Read More

    Structural and rheological changes of lamellar liquid crystals as a result of compositional changes and added silica nanoparticles.
    Phys Chem Chem Phys 2018 Jun 6. Epub 2018 Jun 6.
    School of Chemistry, Monash University, Clayton 3800, Australia.
    Lamellar liquid crystals comprising oil, water and surfactant(s) were formulated and analysed in order to examine how these materials responded to the inclusion of inorganic nanoparticles, in terms of their structural and rheological characteristics. Lamellar phases were formed from mixtures of water, para-xylene and Triton X-100, and analysis was performed via small-angle neutron scattering (SANS), polarising light microscopy (PLM), and amplitude and viscosity sweeps. The partial replacement of Triton X-100 with oleic acid appeared to cause an increase in bilayer thickness, attributed to less efficient packing of the different molecules. Read More

    Fingerprints of flower absolutes using supercritical fluid chromatography hyphenated with high resolution mass spectrometry.
    J Chromatogr B Analyt Technol Biomed Life Sci 2018 Jun 2;1092:1-6. Epub 2018 Jun 2.
    CNRS, Institut de Chimie des Substances Naturelles, UPR2301, Université Paris-Sud, Université Paris-Saclay, Avenue de la Terrasse, 91190 Gif-sur-Yvette, France. Electronic address:
    Supercritical fluid chromatography hyphenated with high resolution mass spectrometry (SFC-HRMS) was developed for fingerprint analysis of different flower absolutes commonly used in cosmetics field, especially in perfumes. Supercritical fluid chromatography-atmospheric pressure photoionization-high resolution mass spectrometry (SFC-APPI-HRMS) technique was employed to identify the components of the fingerprint. The samples were separated with a porous graphitic carbon (PGC) Hypercarb™ column (100 mm × 2. Read More

    Developing Product Environmental Footprint Category Rules (PEFCR) for shampoos - The basis for comparable Life Cycle Assessments.
    Integr Environ Assess Manag 2018 Jun 5. Epub 2018 Jun 5.
    Cosmetics Europe, Avenue Herrmann-Debroux 40, B-1160 Brussels, Belgium.
    In 2013, the European Commission launched the Environmental Footprint Rules pilot phase. This initiative aims at setting specific rules for life cycle assessment (LCA: raw material sourcing, production, logistics, use- and disposal phase) studies within one product category, so called product environmental footprint category rules (PEFCR), as well as for organisations, so called organisational environmental footprint sector rules (OEFSR). Such specific rules for measuring environmental performance throughout the life cycle should facilitate the comparability between LCA studies, and provide principles for communicating the environmental performance, such as transparency, reliability, completeness, and clarity. Read More

    Cinnamic acid derivatives in cosmetics - current use and future prospects.
    Int J Cosmet Sci 2018 Jun 5. Epub 2018 Jun 5.
    Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, Poland.
    Cinnamic acid derivatives are widely used in cosmetics and possess various functions. This group of compounds includes both naturally occurring as well as synthetic substances. On the basis of the Cosmetic Ingredient Database (CosIng) and available literature, this review summarizes their functions in cosmetics, including their physicochemical and biological properties as well as reported adverse effects. Read More

    Utilization of Solid Waste as a Substrate for Production of Oil from Oleaginous Microorganisms.
    J Lipids 2018 16;2018:1578720. Epub 2018 May 16.
    Department of Chemistry, Faculty of Science, Kyambogo University, P.O. Box 1, Kyambogo, Uganda.
    The overwhelming demand of oil and fats to meet the ever increasing needs for biofuel, cosmetics production, and other industrial purposes has enhanced a number of innovations in this industry. One such innovation is the use of microorganisms as alternative sources of oil and fats. Organic solid waste that is causing a big challenge of disposal worldwide is biodegradable and can be utilized as substrate for alternative oil production. Read More

    Converting environmental risks to benefits by using spent coffee grounds (SCG) as a valuable resource.
    Environ Sci Pollut Res Int 2018 Jun 2. Epub 2018 Jun 2.
    Agricultural Research Institute, P.O. Box 22016, CY-1516, Nicosia, Cyprus.
    Coffee is perhaps one of the most vital ingredients in humans' daily life in modern world. However, this causes the production of million tons of relevant wastes, i.e. Read More

    Enhanced synthesis of feruloylated acylglycerols by the lipase-catalyzed transesterification of glyceryl monoferulate with different acyl donors using ionic liquids as reaction solvents.
    J Biotechnol 2018 May 31;280:31-37. Epub 2018 May 31.
    Lipid Technology and Engineering, School of Food Science and Engineering, Henan University of Technology, Lianhua Road 100, Zhengzhou, 450001, Henan Province, PR China. Electronic address:
    Feruloylated acylglycerols (FAG) can be used as antioxidants and UV absorbing ingredients in food and cosmetics. In this work, FAG was prepared by the lipase-catalyzed transesterification of glyceryl monoferulate (GMF) with different acyl donors using ionic liquids (ILs) as reaction solvents. The effect of different imidazolium ILs (BF, PF and TFN) and acyl donors (monoacylglycerols and diacylglycerols) on the transesterification and lipase selectivity for FAG formation were compared. Read More

    Assessing exposure factors in the smartphone generation: Design and evaluation of a smartphone app that collects use patterns of cosmetics and household chemicals.
    Food Chem Toxicol 2018 May 31;118:532-540. Epub 2018 May 31.
    ETH Zurich, Auto-ID Labs, Department of Management, Technology, and Economics, Weinbergstrasse 56-58, 8092 Zurich, Switzerland.
    Exposure factors form the basis of reliable exposure estimates. The growing demand for population-specific exposure factors for complex exposure models is challenged by continuously declining response rates in surveys: Current survey methods clearly need a boost by user-friendly and efficient technologies. We compared the performance of a smartphone app to a paper questionnaire based on a survey on exposure factors that offered the choice between both methods and based on an observational study that investigated the performance of both methods. Read More

    Core microstructure, morphology and chain arrangement of block copolymer self-assemblies as investigated by thermal field-flow fractionation.
    J Chromatogr A 2018 Aug 28;1562:87-95. Epub 2018 May 28.
    Department of Chemistry and Polymer Science, University of Stellenbosch, PO Box X1, 7600 Stellenbosch, South Africa. Electronic address:
    The self-assembly of block copolymers (BCPs), as a result of solvent selectivity for one block, has recently received significant attention due to novel applications of BCPs in pharmaceuticals, biomedicine, cosmetics, electronics and nanotechnology. The correlation of BCP microstructure and the structure of the resulting self-assemblies requires advanced analytical methods. However, traditional bulk characterization techniques are limited in the quest of providing detailed information regarding molar mass (M), hydrodynamic size (D), chemical composition, and morphology for these self-assemblies. Read More

    Cutaneous acceptability of a moisturizing cream in subjects with sensitive skin.
    J Cosmet Dermatol 2018 May 31. Epub 2018 May 31.
    GSK Consumer Healthcare, Weybridge, Surrey, UK.
    Background: Topical cosmetic products can cause adverse reactions in some individuals, particularly those with sensitive skin who may develop irritations or allergic contact dermatitis. Evidence suggests that the frequency of self-reported sensitive skin is increasing in the general population, placing greater importance on clinical testing of topical cosmetics for potential skin reactivity.

    Objectives: To confirm the cutaneous acceptability under normal conditions of use of a moisturizing cream in individuals with sensitive skin. Read More

    Relationship between primary structure or spatial conformation and functional activity of antioxidant peptides from Pinctada fucata.
    Food Chem 2018 Oct 3;264:108-117. Epub 2018 May 3.
    Key Laboratory of Aquatic Product Processing, Ministry of Agriculture, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Science, Guangzhou 510300, China.
    Antioxidant peptides from Pinctada fucata are ubiquitous in nature and can be utilized as ingredients in cosmetics or functional foods to positively regulate oxidative species in the human body against oxidation. Here, mutated peptides and a homologous series of peptides were designed and prepared, based on the original peptide sequence of an antioxidant peptide from Pinctada fucata meat (PFMAP), to better understand the structural relationships, including primary structure, spatial conformation and activity. The results showed that the antioxidant activity factors in order of importance were spatial conformation, amino acid sequence, amino acid position, amino acid composition, peptide chain length and degree of side-chain amino acid glycosylation. Read More

    PM-bound phthalates in indoor and outdoor air in Beijing: Seasonal distributions and human exposure via inhalation.
    Environ Pollut 2018 May 28;241:369-377. Epub 2018 May 28.
    School of Space and Environment, Beihang University, Beijing 100191, China.
    Phthalates (phthalates esters, PAEs) are ubiquitous contaminants in various indoor and outdoor environment. Exposure to PAEs exerts adverse effects on human health. Seasonal variations of air phthalate concentrations and paired indoor and outdoor air phthalate level are rarely known. Read More

    Chemical composition, traditional and professional use in medicine, application in environmental protection, position in food and cosmetics industries, and biotechnological studies of Nasturtium officinale (watercress) - a review.
    Fitoterapia 2018 May 28. Epub 2018 May 28.
    Chair and Department of Pharmaceutical Botany, Jagiellonian University, Collegium Medicum, Medyczna 9, 30-688 Kraków, Poland.
    The herb of Nasturtium officinale is a raw material that has long been used in the traditional medicine of Iran, Azerbaijan, Morocco and Mauritius. Nowadays, this raw material is the object of numerous professional pharmacological studies that have demonstrated its antioxidant, anticancer, antibacterial, anti-inflammatory and cardioprotective properties. These therapeutic effects are caused by glucosinolates present in the plant, isothiocyanates, polyphenols (flavonoids, phenolic acids, proanthocyanidins), terpenes (including carotenoids), vitamins (B, B, B, B, E, C) and bioelements. Read More

    Genetic and metabolic engineering for microbial production of poly-γ-glutamic acid.
    Biotechnol Adv 2018 May 28. Epub 2018 May 28.
    School of Engineering, Massey University, Private Bag 11 222, Palmerston North, New Zealand. Electronic address:
    Poly-γ-glutamic acid (γ-PGA) is a natural biopolymer of glutamic acid. The repeating units of γ-PGA may be derived exclusively from d-glutamic acid, or l-glutamic acid, or both. The monomer units are linked by amide bonds between the α-amino group and the γ-carboxylic acid group. Read More

    A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice.
    Sci Transl Med 2018 May;10(443)
    Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
    Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in more than 2000 consumer products, such as toothpaste, cosmetics, kitchenware, and toys. We report that brief exposure to TCS, at relatively low doses, causes low-grade colonic inflammation, increases colitis, and exacerbates colitis-associated colon cancer in mice. Exposure to TCS alters gut microbiota in mice, and its proinflammatory effect is attenuated in germ-free mice. Read More

    Genomic Identification and Analysis of Specialized Metabolite Biosynthetic Gene Clusters in Plants Using PlantiSMASH.
    Methods Mol Biol 2018 ;1795:173-188
    Bioinformatics Group, Wageningen University, Wageningen, The Netherlands.
    Plants produce a vast diversity of specialized metabolites, which play important roles in the interactions with their microbiome, as well as with animals and other plants. Many such molecules have valuable biological activities that render them (potentially) useful as medicines, flavors and fragrances, nutritional ingredients, or cosmetics. Recently, plant scientists have discovered that the genes for many biosynthetic pathways for the production of such specialized metabolites are physically clustered on the chromosome within biosynthetic gene clusters (BGCs). Read More

    Synthesizing Pickering nanoemulsions by vapor condensation.
    ACS Appl Mater Interfaces 2018 May 30. Epub 2018 May 30.
    Nanoparticle stabilized (Pickering) emulsions are widely used in applications such as cosmetics, drug delivery, membranes and materials synthesis. However, formulating Pickering nanoemulsions remains a significant challenge. Herein, we show that Pickering nanoemulsions can be obtained in a single step even at very low nanoparticle loadings (0. Read More

    Changes in Photosynthetic Pigments, Total Phenolic Content, and Antioxidant Activity of Buc'hoz Ex Etl. Induced by Exogenous Salicylic Acid and Soil Salinity.
    Molecules 2018 May 29;23(6). Epub 2018 May 29.
    Department of Soil Science, Grassland Management and Environmental Chemistry, West Pomeranian University of Technology, Słowackiego 17 Str., Szczecin 71-434, Poland.
    (Lamiaceae) is a promising source of potential antioxidants, and its extracts can be used in pharmaceutical industry, as well as in food products and cosmetics. Salicylic acid (SA) affects many physiological and metabolic processes in vascular plants under salinity stress. The aim of this study was to investigate the response of to either SA, or sodium chloride (NaCl), or a combination of both. Read More

    Determination of Aniline, 4-Aminoazobenzene, and 2-Naphthol in the Color Additive D&C Red No. 17 Using Ultra-High-Performance Liquid Chromatography.
    J AOAC Int 2018 May 18. Epub 2018 May 18.
    U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Cosmetics and Colors, College Park, MD 20740.
    Specifications in the U.S. Code of Federal Regulations for the color additive D&C Red No. Read More

    Application of Anthocyanins from Blackcurrant ( Ribes nigrum L.) Fruit Waste as Renewable Hair Dyes.
    J Agric Food Chem 2018 May 29. Epub 2018 May 29.
    Sustainable Materials Research Group, School of Design , University of Leeds , Leeds LS2 9JT , United Kingdom.
    There is much concern about the toxicological effects of synthetic hair dyes. As an alternative approach, renewable waste blackcurrant ( Ribes nigrum L.) fruit skins from the fruit pressing industry were extracted using acidified water with a solid-phase purification stage. Read More

    Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice.
    J Cosmet Dermatol 2018 May 28. Epub 2018 May 28.
    Department of Pharmaceutical Science & Engineering, Seowon University, Cheongju, South Korea.
    Background: Costunolide (COS), a naturally occurring sesquiterpene lactone, is known to exert anti-inflammatory, antioxidant, and anticancer effects. This study was undertaken to investigate the effects of costunolide on the promotion of hair growth.

    Methods: Real-time cell analyzer (RTCA), measurement of 5α-reductase activity, mRNA expression, and Western blotting were adopted to address whether COS can stimulate the proliferation of human hair follicle dermal papilla cells (hHFDPCs). Read More

    First report of Nitzschia navis-varingica in the Mediterranean Sea and growth stimulatory effects of Nitzschia navis-varingica, Chrysochromulina alifera and Heterocapsa pygmaea on different mammalian cell types.
    Mol Biol Rep 2018 May 28. Epub 2018 May 28.
    Department of Biotechnology, Institute of Graduate Studies in Science, Mersin University, Ciftlikkoy, 33343, Mersin, Turkey.
    A benthic diatom, Nitzschia navis-varingica was found for the first time in the Mediterranean Sea. Effects of this diatom species together with the haptophyte Chrysochromulina alifera and the dinoflagellate Heterocapsa pygmaea isolated from the northeastern Mediterranean Sea coast on prostate, breast cancer and fibroblast cell lines were investigated. Algal extracts did not exert any toxic effect on these cell lines and it had growth stimulatory impact on the cells without discrimination of cell type. Read More

    Advances in synthetic biology of oleaginous yeast Yarrowia lipolytica for producing non-native chemicals.
    Appl Microbiol Biotechnol 2018 May 28. Epub 2018 May 28.
    The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, Denmark.
    Oleaginous yeast Yarrowia lipolytica is an important industrial host for the production of enzymes, oils, fragrances, surfactants, cosmetics, and pharmaceuticals. More recently, improved synthetic biology tools have allowed more extensive engineering of this yeast species, which lead to the production of non-native metabolites. In this review, we summarize the recent advances of genome editing tools for Y. Read More

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