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    Screening of physicochemical treatment processes for reducing toxicity of hair care products wastewaters.
    J Environ Manage 2018 Feb 14;212:349-356. Epub 2018 Feb 14.
    Departament of Civil Engineering, Federal University of Viçosa, Minas Gerais, Brazil.
    Toxicity reduction in wastewaters from small hair care products manufacturing companies using coagulation/flocculation/sedimentation or flotation, membrane separation and powdered activated charcoal adsorption was evaluated. Raw wastewater composition varied widely within and especially between companies, but all exhibited high acute toxicity to Daphnia similis (EC(I)50; 48 h < 0.02-0. Read More

    Expression and characterization of recombinant rattusin, an α-defensin-related peptide with a homodimeric scaffold formed by intermolecular disulfide exchanges.
    Protein Expr Purif 2018 Feb 14. Epub 2018 Feb 14.
    Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address:
    Rattusin is an α-defensin-related peptide isolated from the small intestine of rats. The primary sequence of linear rattusin is composed of 31 amino acids containing five cysteines with a unique spacing pattern. It forms a homodimeric scaffold in which the primary structure occurs in an antiparallel fashion formed by five intermolecular disulfide (SS) bonds. Read More

    Detection of DNA Damage Induced by Cerium Dioxide Nanoparticles: From Models to Molecular Mechanism Activated.
    Adv Exp Med Biol 2018 ;1048:215-226
    Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto; USP, Ribeirão Preto, São Paulo, Brazil.
    This chapter will present an original effort to summarize the relevant data about the cyto-genotoxicity induced by cerium dioxide nanoparticles (nanoceria) in physiologically (in vivo and in vitro) relevant models. In this way, this chapter should be extremely useful to everyone who wants to plan their research and publishing their results. Massive application of nanoceria at different fields is increasing year after year, and it is urgent to address and discuss their use and its safety-related issues. Read More

    Production of chitinase from Escherichia fergusonii, chitosanase from Chryseobacterium indologenes, Comamonas koreensis and its application in N-acetylglucosamine production.
    Int J Biol Macromol 2018 Feb 13. Epub 2018 Feb 13.
    Dairy Science Division, National Institute of Animal Science, Rural Development Administration, #114, Shinbang 1Gil, Seonghwan-eup, Seobuk-gu, Cheonan-si, Chungcheongnam-do 31000, Republic of Korea. Electronic address:
    The important platform polysaccharide N-acetylglucosamine (GlcNAc) has great potential to be used in the fields of food, cosmetics, agricultural, pharmaceutical, medicine and biotechnology. This GlcNAc is being produced by traditional methods of environment-unfriendly chemical digestion with strong acids. Therefore, researchers have been paying more attention to enzymatic hydrolysis process for the production of GlcNAc. Read More

    Preparation andEvaluation of Elastic Nanoliposomes for Topical Delivery of Highly Skin-Permeable Growth Factors.
    J Nanosci Nanotechnol 2018 Feb;18(2):887-892
    College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam 58554, Republic of Korea.
    Percutaneous delivery of growth factors is often used to treat wounds, and for cosmetic purposes, as a way of accelerating healing and skin regeneration, respectively. However, the therapeutic effects of growth factors are diminished by their poor absorption when delivered percutaneously, in addition to their rapid degradation by proteinases. To overcome these obstacles, we constructed two skin-permeable compounds. Read More

    Toxicology of Engineered Nanoparticles: Focus on Poly(amidoamine) Dendrimers.
    Int J Environ Res Public Health 2018 Feb 14;15(2). Epub 2018 Feb 14.
    FOCAS Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland.
    Engineered nanomaterials are increasingly being developed for paints, sunscreens, cosmetics, industrial lubricants, tyres, semiconductor devices, and also for biomedical applications such as in diagnostics, therapeutics, and contrast agents. As a result, nanomaterials are being manufactured, transported, and used in larger and larger quantities, and potential impacts on environmental and human health have been raised. Poly(amidoamine) (PAMAM) dendrimers are specifically suitable for biomedical applications. Read More

    smartLipidsas third solid lipid nanoparticle generation - stabilization of retinol for dermal application.
    Pharmazie 2017 Dec;72(12):728-735
    smartLipids® as the 3rd lipid nanoparticle generation are made from a complex lipid mixture. The chaotic particle matrix structure provides higher loading with actives and a firmer inclusion inside the particle matrix being more protective for chemically labile molecules. Thus, these particles were used to develop an optimized retinol formulation. Read More

    Hepatotoxicity, nephrotoxicity, and drug/chemical interaction toxicity of platinum nanoparticles in mice.
    Pharmazie 2017 Jan;72(1):10-16
    Nanomaterials are frequently used in microelectronics, cosmetics, and sunscreens. Platinum reagents are commonly used in disease diagnosis, cosmetics, and the food industry. Although research into the development of nanomaterialbased drug delivery systems has yielded promising results, the toxicity of these materials is not fully understood. Read More

    Role of solid lipid nanoparticles as photoprotective agents in cosmetics.
    J Cosmet Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte University, Mangalore, India.
    Background: Novel drug delivery systems have gained popularity since last two decades because of its advantages over conventional dosage forms. Effect of UV radiation on skin can cause either acute or chronic damage to our skin. Solid lipid nanoparticles (SLNs) were developed as novel carrier over the conventional carrier systems like liposomes and emulsions. Read More

    Nanosilver: new ageless and versatile biomedical therapeutic scaffold.
    Int J Nanomedicine 2018 2;13:733-762. Epub 2018 Feb 2.
    College of Plant Sciences and Technology.
    Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer. Read More

    Secreted protein extract analyses present the plant pathogen Alternaria alternata as a suitable industrial enzyme toolbox.
    J Proteomics 2018 Feb 10. Epub 2018 Feb 10.
    INBIOTEC (Instituto de Biotecnología de León), Avda. Real 1 - Parque Científico de León, 24006 León, Spain; Departamento de Biología Molecular, Universidad de León, Campus de Ponferrada, Avda. Astorga s/n, 24401 Ponferrada, Spain. Electronic address:
    Lignocellulosic plant biomass is the most abundant carbon source in the planet, which makes it a potential substrate for biorefinery. It consists of polysaccharides and other molecules with applications in pharmaceutical, food and feed, cosmetics, paper and textile industries. The exploitation of these resources requires the hydrolysis of the plant cell wall, which is a complex process. Read More

    Biological properties and pharmacological potential of plant exudates.
    Food Res Int 2018 Mar 21;105:1039-1053. Epub 2017 Nov 21.
    Health Sciences Graduate Program, Biological and Health Sciences Center, Federal University of Maranhao, Sao Luís, MA, Brazil. Electronic address:
    Exudates released from plants, consist of complex mixtures of organic and inorganic molecules that have been used in traditional medicine from several years. They may vary among genera, species or within a genus and mainly include latex, sap, gums, resins, seed or root exudates. Plant exudates are known to possess several biological activities including, antimicrobial, anti-inflammatory, antioxidant, wound healing and anti-nociceptive. Read More

    Influence of Parabens on Bacteria and Fungi Cellular Membranes: Studies in Model Two-Dimensional Lipid Systems.
    J Phys Chem B 2018 Feb 15. Epub 2018 Feb 15.
    Department of Environmental Chemistry, Faculty of Chemistry and ‡Department of Physical Chemistry and Electrochemistry, Faculty of Chemistry, Jagiellonian University , Gronostajowa 2, 30-387 Kraków, Poland.
    Langmuir monolayers were used to study the influence of four commercially applied parabens on multicomponent systems composed of lipid species characteristic of the cellular membrane of microorganisms found in carbohydrates and proteins reaching products, including food and cosmetics. The aim of the undertaken studies was to shed new light on the problem of parabens' interactions with membrane lipids and their affinity for monolayers differing with regard to the composition, mutual lipid ratios, and physicochemical properties. The discussion is based on the π-A isotherm characteristics, surface morphology observation performed with BAM, and analysis of the diffraction data collected for the periodically ordered lipid domains present in the investigated multicomponent films. Read More

    Analysis of Antibacterial Activity and Bioactive Compounds of the Giant Mushroom, Macrocybe gigantea (Agaricomycetes), from India.
    Int J Med Mushrooms 2017 ;19(12):1083-1092
    Department of Biological Sciences, College of Basic Sciences & Humanities, G.B. Pant University of Agriculture & Technology, Pantnagar 263145 (U.S. Nagar, Uttarakhand), India.
    The antibacterial activity, phenolic profile, and bioactive compounds of fruiting bodies from 2 strains (MA1 and MA2) of the giant mushroom Macrocybe gigantea were evaluated to access their nutraceutical efficacy. The antibacterial activity was higher in MA2 against all selected pathogenic bacteria. Selected phenolics were analyzed by high-performance liquid chromatography coupled with ultraviolet-visible detection. Read More


    [Focusing on the ocular surface problems induced by cosmetology].
    Zhonghua Yan Ke Za Zhi 2018 Feb;54(2):84-86
    Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
    Making oneself more beautiful has always been part of humans' civilized life. Accordingly, the side effects of various cosmetic product and cosmetic procedure long exist. The ocular-surface problems induced by cosmetology mainly include cornea and conjunctiva damages, and tear film damages. Read More

    Effects of Several Cosmetic Preservatives on ROS-Dependent Apoptosis of Rat Neural Progenitor Cells.
    Biomol Ther (Seoul) 2018 Feb 12. Epub 2018 Feb 12.
    Department of Neuroscience, School of Medicine and Center for Neuroscience Research, Konkuk University, Seoul 05029, Republic of Korea.
    Benzalkonium chloride, diazolidinyl urea, and imidazolidinyl urea are commonly used preservatives in cosmetics. Recent reports suggested that these compounds may have cellular and systemic toxicity in high concentration. In addition, diazolidinyl urea and imidazolidinyl urea are known formaldehyde (FA) releasers, raising concerns for these cosmetic preservatives. Read More

    Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study.
    Skin Pharmacol Physiol 2018 Feb 9;31(2):99-106. Epub 2018 Feb 9.
    Bioscreening Unit, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.
    Background: Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. Read More

    Influence of glycosaminoglycans on the properties of thin films based on chitosan/collagen blends.
    J Mech Behav Biomed Mater 2018 Feb 6;80:189-193. Epub 2018 Feb 6.
    Department of Chemistry of Biomaterials and Cosmetics, Faculty of Chemistry, Nicolaus Copernicus University, Toruń, Poland.
    Thin films based on chitosan, collagen, and glycosaminoglycans isolated from fish skin were obtained by solvent evaporation. The films were characterized by different analyses, e.g. Read More

    Limonene: Aroma of innovation in health and disease.
    Chem Biol Interact 2018 Feb 7;283:97-106. Epub 2018 Feb 7.
    São Paulo State University (UNESP), Institute of Biosciences, Department of Morphology, Botucatu, Brazil. Electronic address:
    Natural products obtained in dietary components may aid the prevention and treatment of a variety of diseases. Reports in the scientific literature have demonstrated that the consumption of terpenes is a successful alternative in the treatment of several diseases, triggering beneficial biological effects in clinical and preclinical studies. The monoterpene limonene is largely used in alimentary items, cleaning products, and it is one of the most frequent fragrances used in cosmetics formulation. Read More

    Fluorescence studies on the aggregation behaviors of collagen modified with NHS-activated poly(γ-glutamic acid).
    Int J Biol Macromol 2018 Feb 6. Epub 2018 Feb 6.
    College of Ecological Environment and Urban Construction, Fujian University of Technology, Fuzhou 350108, PR China. Electronic address:
    The poly(γ-glutamic acid)-NHS (γ-PGA-NHS) esters were used to endow collagen with both of excellent water-solubility and thermal stability via cross-linking reaction between γ-PGA-NHS and collagen. In the present work, the effect of γ-PGA-NHS on the aggregation of collagen molecules was studied by fluorescence techniques. The fluorescence emission spectra of pyrene in collagen solutions and the intrinsic fluorescence emission spectra of collagen suggested different effects of γ-PGA-NHS on collagen molecules: inhibiting aggregation below critical aggregation concentration (CAC) and promoting aggregation above CAC. Read More

    Recent approaches in the development of phytolipid complexes as novel drug delivery.
    Curr Drug Deliv 2018 Feb 8. Epub 2018 Feb 8.
    Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Annaram, Medhak (Dt), Telangana. India.
    The imbalance of hydrophilicity, and lipophilicity along with, a large molecular size (due to a unique chemical structure) of natural compounds, or plant actives pose a significant challenge for their absorption through a biological membrane and thus, alters the therapeutic efficacy. Therefore, it is desirable to have a novel approach for such formulation in order to improve the solubility and bioavailability, of these phytoconstituents as a phospholipid complexation. Herbal drugs are precisely, embedded and bound by phospholipids to form vesicular structures, which are amphoteric in nature. Read More

    Nanodiamonds for In Vivo Applications.
    Small 2018 Feb 9. Epub 2018 Feb 9.
    University Medical Center Groningen, Groningen University, Antonius Deusinglaan 1, 9713, AW, Groningen, Netherlands.
    Due to their unique optical properties, diamonds are the most valued gemstones. However, beyond the sparkle, diamonds have a number of unique properties. Their extreme hardness gives them outstanding performance as abrasives and cutting tools. Read More

    Growth promotion of Euglena gracilis by ferulic acid from rice bran.
    AMB Express 2018 Feb 8;8(1):16. Epub 2018 Feb 8.
    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Fukuoka, 808-0196, Japan.
    A significant growth promotion of Euglena gracilis was achieved by simply adding ferulic acid from rice bran without diminishing the accumulation of valuable products like paramylon. E. gracilis is a freshwater microalga that is widely applied in cosmetics, food, medicine, and supplements, and it is considered a potential source of biofuel. Read More

    Taste masking and rheology improvement of drug complexed with beta-cyclodextrin and hydroxypropyl-β-cyclodextrin by hot-melt extrusion.
    Carbohydr Polym 2018 Apr 4;185:19-26. Epub 2018 Jan 4.
    Laboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, Brasília, DF, 70.910-900, Brazil. Electronic address:
    This study aimed to mask fluconazole (FLU) taste and improve its rheological properties by an efficient process of cyclodextrin complexation. For this, hot-melt extrusion (HME) was used to obtain extrudates composed of FLU, hydroxypropylcellulose, and one of two different cyclodextrins (β-cyclodextrin or hydroxypropyl-β-cyclodextrin) maintaining the drug:cyclodextrin molar ratio at 1:0.3 or 1:0. Read More

    Enzymatically and chemically oxidized lignin nanoparticles for biomaterial applications.
    Enzyme Microb Technol 2018 Apr 10;111:48-56. Epub 2018 Jan 10.
    Bioproduct Chemistry, Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P.O. Box 16300, FI-00076 Aalto, Espoo, Finland. Electronic address:
    Cross-linked and decolorized lignin nanoparticles (LNPs) were prepared enzymatically and chemically from softwood Kraft lignin. Colloidal lignin particles (CLPs, ca. 200 nm) in a non-malodorous aqueous dispersion could be dried and redispersed in tetrahydrofuran (THF) or in water retaining their stability i. Read More

    [Technological development of alternative method to animal experiments in Japan].
    Nihon Yakurigaku Zasshi 2018 ;151(2):48-51
    Division of Community Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, Kitasato University School of Pharmacy.
    The alternative method to animal experiments is based on 3Rs (Replacement, Reduction, Refinement) of animal experiments. The use of an alternative method to animal experiment has become a global trend in chemical substances, pharmaceuticals, medical equipment, agrochemicals, as well as cosmetics for which animal testing within the EU area was prohibited by the EU directive. Here, the progress of alternative method research to animal experiment in Japan, and recent topics on the development of "replacement" in cell culture, non mammalian, non vertebrates and in silico as technical aspects are described. Read More

    Antibacterial activities of R-(+)-Limonene emulsion stabilized by Ulva fasciata polysaccharide for fruit preservation.
    Int J Biol Macromol 2018 Jan 28;111:1273-1280. Epub 2018 Jan 28.
    R &D Center, Proya Cosmetics Co. Ltd., Hangzhou 310012, PR China.
    It was previously found that R-(+)-Limonene emulsion could be stabilized by Ulva fasciata polysaccharide. In the present study, emulsions of R-(+)-Limonene were developed for coating of strawberries to improve the shelf life and microbiological safety. Edible coatings with at least 0. Read More

    A reagent-assisted method in SERS detection of methyl salicylate.
    Spectrochim Acta A Mol Biomol Spectrosc 2018 Jan 31;195:172-175. Epub 2018 Jan 31.
    Department of Chemistry, Institute for Molecular Science and Fusion Technology, Kangwon National University, Chunchon 24341, Republic of Korea. Electronic address:
    With the explosive application of methyl salicylate (MS) molecules in food and cosmetics, the further detection of MS molecules becomes particularly important. Here we investigated the detection of MS molecules based on surface-enhanced Raman scattering (SERS) in a novel molecule/assistant/metal system constructed with MS, 4,4'-(hexafluoroisopropylidene) bis (benzoic acid) and Ag nanoparticles (AgNPs). The minimum detection concentration is 10 M. Read More

    Triclosan affects axon formation in the neural development stages of zebrafish embryos (Danio rerio).
    Environ Pollut 2018 Feb 2;236:304-312. Epub 2018 Feb 2.
    Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, South Korea. Electronic address:
    Triclosan (TCS) is an organic compound with a wide range of antibiotic activity and has been widely used in items ranging from hygiene products to cosmetics; however, recent studies suggest that it has several adverse effects. In particular, TCS can be passed to both fetus and infants, and while some evidence suggests in vitro neurotoxicity, there are currently few studies concerning the mechanisms of TCS-induced developmental neurotoxicity. Therefore, this study aimed to clarify the effect of TCS on neural development using zebrafish models, by analyzing the morphological changes, the alterations observed in fluorescence using HuC-GFP and Olig2-dsRED transgenic zebrafish models, and neurodevelopmental gene expression. Read More

    Enhanced single cell oil production by mixed culture of Chlorella pyrenoidosa and Rhodotorula glutinis using cassava bagasse hydrolysate as carbon source.
    Bioresour Technol 2018 Feb 2;255:140-148. Epub 2018 Feb 2.
    School of Food Sciences and Engineering, South China University of Technology, Wushan Rd. 381, Guangzhou 510641, PR China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China. Electronic address:
    The single cell oil (SCO) production by the mono and mixed culture of microalgae Chlorella pyrenoidosa and red yeast Rhodotorula glutinis was investigated using non-detoxified cassava bagasse hydrolysate (CBH) as carbon source. The results suggested that the two strains were able to tolerate and even degrade some byproducts presented in the CBH, and the mixed culture approach enhanced the degradation of certain byproducts. Biomass (20. Read More

    Assessment of oral formulation-dependent characteristics of orodispersible tablets using texture profiles and multivariate data analysis.
    J Pharm Biomed Anal 2018 Jan 29;152:47-56. Epub 2018 Jan 29.
    Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hațieganu", V. Babeș nr. 41, Cluj-Napoca, 400012, Romania.
    Orodispersible tablets (ODTs) emerged as dosage forms recommended for special groups of patients like pediatrics or geriatrics, due to their multiple advantages. Among their critical quality attributes, palatability determines patient acceptance, with high impact on treatment efficacy. The aim of this study was to develop an instrumental method to assess in vivo disintegration time and palatability of ODTs. Read More

    Temporal acclimation of Microchloropsis gaditana CCMP526 in response to hypersalinity.
    Bioresour Technol 2018 Jan 16;254:23-30. Epub 2018 Jan 16.
    Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India. Electronic address:
    Evaporation from culture ponds and raceways can subject algae to hypersalinity stress, and this is exacerbated by global warming. We investigated the effect of salinity on a marine microalga, Microchloropsis gaditana, which is of industrial significance because of its high lipid-accumulating capability. Both short-term (hours) and medium-term (days) effects of salinity were studied across various salinities (37. Read More

    Aerogel from chemo-enzymatically oxidized fenugreek gum: an innovative delivery system of isothiazolinones biocides.
    Appl Microbiol Biotechnol 2018 Feb 6. Epub 2018 Feb 6.
    Istituto di Chimica del Riconoscimento Molecolare (ICRM), C.N.R, Via Mario Bianco 9, 20131, Milan, Italy.
    Aerogels of chemo-enzymatically oxidized, lyophilized fenugreek gum (EOLFG) were evaluated as "delivery system" (DS) of the microbiocide mix 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) and 2-methyl-4-isothiazolin-3-one (MIT). These biocides have a broad activity spectrum and a low MIC (minimal inhibitory concentration) in the ppm range. They are approved under the EU Biocidal Product Directive for various applications, including cosmetics, are classified as skin sensitizers, and are under increasing scrutiny to limit or eliminate their use. Read More

    Skin Color, Cultural Capital, and Beauty Products: An Investigation of the Use of Skin Fairness Products in Mumbai, India.
    Front Public Health 2017 23;5:365. Epub 2018 Jan 23.
    Centre for Appearance Research, University of the West of England, Bristol, United Kingdom.
    The use of skin fairness products that frequently contain toxic ingredients is associated with significant adverse health side effects. Due to the high prevalence of use in Asian and African countries, skin fairness product use is recognized as a growing public health concern. The multi-million-dollar skin fairness product industry has also been criticized for perpetuating racism and social inequalities by reinforcing beliefs about the benefits of skin fairness for cultural capital. Read More

    Impact of cell types and culture methods on the functionality of in vitro liver systems - A review of cell systems for hepatotoxicity assessment.
    Toxicol In Vitro 2018 Feb 1;48:262-275. Epub 2018 Feb 1.
    Department of Applied Mathematics, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom.
    Xenobiotic safety assessment is an area that impacts a multitude of different industry sectors such as medicinal drugs, agrochemicals, industrial chemicals, cosmetics and environmental contaminants. As such there are a number of well-developed in vitro, in vivo and in silico approaches to evaluate their properties and potential impact on the environment and to humans. Additionally, there is the continual investment in multidisciplinary scientists to explore non-animal surrogate technologies to predict specific toxicological outcomes and to improve our understanding of the biological processes regarding the toxic potential of xenobiotics. Read More

    Chitosan-based nanosystems and their exploited antimicrobial activity.
    Eur J Pharm Sci 2018 Feb 3;117:8-20. Epub 2018 Feb 3.
    School of Pharmacy, University of Camerino, Via Gentile III da Varano, Camerino, MC, Italy. Electronic address:
    Chitosan is a biodegradable and biocompatible natural polysaccharide that has a wide range of applications in the field of pharmaceutics, biomedical, chemical, cosmetics, textile and food industry. One of the most interesting characteristics of chitosan is its antibacterial and antifungal activity, and together with its excellent safety profile in human, it has attracted considerable attention in various research disciplines. The antimicrobial activity of chitosan is dependent on a number of factors, including its molecular weight, degree of deacetylation, degree of substitution, physical form, as well as structural properties of the cell wall of the target microorganisms. Read More

    Physicochemical, functional, and biological properties of water-soluble polysaccharides from Rosa roxburghii Tratt fruit.
    Food Chem 2018 May 6;249:127-135. Epub 2018 Jan 6.
    School of Food Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China. Electronic address:
    Water-soluble polysaccharides (RTFP) were extracted from Rosa roxburghii Tratt fruit by hot water method. The physicochemical, functional, and hypoglycemic properties of RTFP were investigated. The results revealed that RTFP mainly contained carbohydrates (63. Read More

    Pollution patterns and underlying relationships of benzophenone-type UV-filters in wastewater treatment plants and their receiving surface water.
    Ecotoxicol Environ Saf 2018 Jan 26;152:98-103. Epub 2018 Jan 26.
    Institute of Applied Radiation of Shanghai, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China. Electronic address:
    The environmental behaviors of emerging pollutants, benzophenone-type UV filters (BP-UV filters) and their derivatives were investigated in four wastewater treatment plants (WWTPs), and their receiving surface waters in Shanghai. The concentration level of selected BP-UV filters in the WWTPs was detected from ngLto μgL. BP (621-951ngL) and BP-3 (841-1. Read More

    Safety assessment of starch-based personal care products: Nanocapsules and pickering emulsions.
    Toxicol Appl Pharmacol 2018 Jan 31;342:14-21. Epub 2018 Jan 31.
    Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal. Electronic address:
    The safety profile of the ingredients used in topical dosage forms and its evaluation is an issue of utmost importance. A suitable equilibrium between safety and efficacy is crucial before promoting a dermatological product. The aim of this work was to assess the safety and biological effects of starch-based vehicles (St-BV) used in such products. Read More

    L-cysteine production in Escherichia colibased on rational metabolic engineering and modular strategy.
    Biotechnol J 2018 Feb 6. Epub 2018 Feb 6.
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
    L-cysteine is an amino acid with important physiological functions and has a wide range of applications in medicine, food, animal feed and cosmetics industry. In this study, the L-cysteine synthesis in E. coli was divided into four modules: the transport module, sulfur module, precursor module, and degradation module. Read More

    Blue light filtered white light induces depression-like responses and temporary spatial learning deficits in rats.
    Photochem Photobiol Sci 2018 Feb 6. Epub 2018 Feb 6.
    Department of Toxicology, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. and Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, China.
    Objectives: Ambient light has a vital impact on mood and cognitive functions. Blue light has been previously reported to play a salient role in the antidepressant effect via melanopsin. Whether blue light filtered white light (BFW) affects mood and cognitive functions remains unclear. Read More

    Current state of follow-up care for patients with Hymenoptera venom anaphylaxis in southwest Germany: Major impact of early information.
    Allergo J Int 2018 16;27(1):4-14. Epub 2018 Jan 16.
    1Department of Dermatology, Allergy Research Group, Medical Center, University of Freiburg, Freiburg, Germany.
    Background: Up to 3.5% of the population experience anaphylactic reactions in response to Hymenoptera stings. Current guidelines are in place for the diagnostic workup and follow-up care of patients with Hymenoptera venom anaphylaxis (HVA). Read More

    fruit extracts rich in methyl linoleate and methyl linolenate downregulate melanogenesis via the Akt/GSK3β signaling pathway.
    Nutr Res Pract 2018 Feb 18;12(1):3-12. Epub 2018 Jan 18.
    Faculty of Biotechnology, College of Applied Life Sciences, SARI, Jeju National University, 102, Jejudaehak-ro, Jeju-si, Jeju 63243, Korea.
    Background/objectives: is traditionally used as a medicinal herb to treat various diseases, including skin disorders, in China and Korea. This study evaluated the inhibitory effect offruit on melanogenesis and its underlying mechanisms in B16F10 mouse melanoma cells. The active chemical compounds in anti-melanogenesis were determined in. Read More

    3D printed models in mandibular reconstruction with bony free flaps.
    J Mater Sci Mater Med 2018 Feb 2;29(3):23. Epub 2018 Feb 2.
    Poznan University of Technology Chair of Management and Production Engineering, Poznań, Poland.
    The aim of the study was to compare two types of mandible reconstructive operations with scapula and fibula free flaps: procedures with 3-D models from thermoplastic materials and conventional planning surgeries. 8 patients were treated due to an advanced oral cavity squamous cell carcinoma. In four patients with a mandibular defect, a physical 3-D model consisting of the reconstructed and unaffected sites was prepared for a reconstruction protocol. Read More

    Mercury Poisoning in a Toddler from Home Contamination due to Skin-Lightening Cream.
    J Pediatr 2018 Jan 30. Epub 2018 Jan 30.
    Arizona Poison and Drug Information Center, University of Arizona, Tucson, AZ.
    A 17-month-old child presented with hypertension, fussiness, constipation, and arthralgia due to mercury toxicity from a skin-lightening cosmetic used by her mother and grandmother. Blood mercury level was 26 mcg/L and urine level was 243 mcg/g creatinine. She was chelated with succimer. Read More

    Engineering Escherichia coli for glycolic acid production from D-xylose through the Dahms pathway and glyoxylate bypass.
    Appl Microbiol Biotechnol 2018 Mar 1;102(5):2179-2189. Epub 2018 Feb 1.
    Department of Energy Science and Technology (DEST), Energy and Environment Fusion Technology Center (E2FTC), Myongji University, Myongji-ro 116, Cheoin-gu, Yongin, Gyeonggi-do, 170-58, South Korea.
    Glycolic acid (GA) is an ⍺-hydroxy acid used in cosmetics, packaging, and medical industries due to its excellent properties, especially in its polymeric form. In this study, Escherichia coli was engineered to produce GA from D-xylose by linking the Dahms pathway, the glyoxylate bypass, and the partial reverse glyoxylate pathway (RGP). Initially, a GA-producing strain was constructed by disrupting the xylAB and glcD genes in the E. Read More

    D-lyxose isomerase and its application for functional sugar production.
    Appl Microbiol Biotechnol 2018 Mar 1;102(5):2051-2062. Epub 2018 Feb 1.
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
    Functional sugars have attracted attention because of their wide application prospects in the food, cosmetics, and pharmaceutical industries in recent decades. Compared with complex chemical synthesis, enzymatic methods of creating functional sugars, characterized by high specificity, moderate reaction conditions, and sustainability, are favored. D-lyxose isomerase (D-LI, EC 5. Read More

    Super-resolution optical microscopy resolves network morphology of smart colloidal microgels.
    Phys Chem Chem Phys 2018 Feb;20(7):5074-5083
    Biomolecular Photonics, Department of Physics, Bielefeld University, Bielefeld, Germany.
    We present a new method to resolve the network morphology of colloidal particles in an aqueous environment via super-resolution microscopy. By localization of freely diffusing fluorophores inside the particle network we can resolve the three dimensional structure of one species of colloidal particles (thermoresponsive microgels) without altering their chemical composition through copolymerization with fluorescent monomers. Our approach utilizes the interaction of the fluorescent dye rhodamine 6G with the polymer network to achieve an indirect labeling. Read More

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