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    Determination of Organic Impurities in Anthraquinone Color Additives D&C Violet No. 2 and D&C Green No. 6 by Ultra-High Performance Liquid Chromatography.
    J AOAC Int 2017 Jan;100(1):230-235
    U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Cosmetics and Colors, College Park, MD 20740, USA.
    A new practical and time-saving ultra-high performance liquid chromatography (UHPLC) method has been developed for determining the organic impurities in the anthraquinone color additives D&C Violet No. 2 and D&C Green No. 6. Read More

    Rapid identification of pearl powder from Hyriopsis cumingii by Tri-step infrared spectroscopy combined with computer vision technology.
    Spectrochim Acta A Mol Biomol Spectrosc 2017 Aug 10;189:265-274. Epub 2017 Aug 10.
    College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, PR China. Electronic address:
    Pearl powder, an important raw material in cosmetics and Chinese patent medicines, is commonly uneven in quality and frequently adulterated with low-cost shell powder in the market. The aim of this study is to establish an adequate approach based on Tri-step infrared spectroscopy with enhancing resolution combined with chemometrics for qualitative identification of pearl powder originated from three different quality grades of pearls and quantitative prediction of the proportions of shell powder adulterated in pearl powder. Additionally, computer vision technology (E-eyes) can investigate the color difference among different pearl powders and make it traceable to the pearl quality trait-visual color categories. Read More

    Determination of iodopropynyl butylcarbamate in cosmetic formulations utilizing pulsed splitless injection, gas chromatography with electron capture detector.
    J Chromatogr A 2017 Jul 24. Epub 2017 Jul 24.
    Unilever R&D Centre, 40 Merritt Blvd, Trumbull, CT, USA.
    Current analytical methodology for iodopropynyl butylcarbamate (IPBC) analysis focuses on the use of liquid chromatography and mass spectrometer (LC-MS), but the high instrumentation and operator investment required has resulted in the need for a cost effective alternative methodology. Past publications investigating gas chromatography with electron capture detector (GC-ECD) for IPBC quantitation proved largely unsuccessful, likely due to the preservatives limited thermal stability. The use of pulsed injection techniques commonly used for trace analysis of thermally labile pharmaceutical compounds was successfully adapted for IPBC analysis and utilizes the selectivity of GC-ECD analysis. Read More

    Sub-chronic exposure to low concentration of dibutyl phthalate affects anthropometric parameters and markers of obesity in rats.
    Environ Sci Pollut Res Int 2017 Aug 19. Epub 2017 Aug 19.
    Department of Animal Nutrition, University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan.
    Dibutyl phthalate is an important phthalate ester extensively used in various products like plastics, adhesives, inks, pharmaceuticals, lacquers, varnishes, paper coatings, safety glasses, and cosmetics. The exposure of DBP to "one's health" is therefore inevitable. The present study focuses on elucidating the effect of low doses of DBP on anthropometric parameters and markers of obesity in rats in a 13-week study. Read More

    The environmental injustice of beauty: framing chemical exposures from beauty products as a health disparities concern.
    Am J Obstet Gynecol 2017 Aug 14. Epub 2017 Aug 14.
    Urban and Environmental Policy Department, Occidental College, Los Angeles, CA.
    The obstetrics-gynecology community has issued a call to action to prevent toxic environmental chemical exposures and their threats to healthy human reproduction. Recent committee opinions recognize that vulnerable and underserved women may be impacted disproportionately by environmental chemical exposures and recommend that reproductive health professionals champion policies that secure environmental justice. Beauty product use is an understudied source of environmental chemical exposures. Read More

    Microparticles prepared with 50-190kDa chitosan as promising non-toxic carriers for pulmonary delivery of isoniazid.
    Carbohydr Polym 2017 Oct 23;174:421-431. Epub 2017 Jun 23.
    Laboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, 70.910-900 Brasília, DF, Brazil. Electronic address:
    Chitosan biocompatibility and mucoadhesiveness make it an ideal polymer for antituberculotic drugs microcapsulation for pulmonary delivery. Yet, previous study indicated toxicity problems to J-774.1-cells treated with some medium molecular weight (190-310kDa) chitosan microparticles. Read More

    Phase Behaviour and Miscibility Studies of Collagen/Silk Fibroin Macromolecular System in Dilute Solutions and Solid State.
    Molecules 2017 Aug 18;22(8). Epub 2017 Aug 18.
    i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal.
    Miscibility is an important issue in biopolymer blends for analysis of the behavior of polymer pairs through the detection of phase separation and improvement of the mechanical and physical properties of the blend. This study presents the formulation of a stable and one-phase mixture of collagen and regenerated silk fibroin (RSF), with the highest miscibility ratio between these two macromolecules, through inducing electrostatic interactions, using salt ions. For this aim, a ternary phase diagram was experimentally built for the mixtures, based on observations of phase behavior of blend solutions with various ratios. Read More

    Description of Actinokineospora acnipugnans sp. nov., an actinomycete isolated from soil, showing potential uses in cosmetics.
    Int J Syst Evol Microbiol 2017 Aug 18. Epub 2017 Aug 18.
    1​Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Gyeonggi-Do 16227, Republic of Korea.
    During isolation of soil bacteria having antibacterial functions, an aerobic, Gram-stain-positive, oxidase-negative, catalase-positive bacterium, designated strain R434T, was isolated. Strain R434T showed antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis and significant enzyme-inhibitory capability. The diagnostic diamino acid of the cell-wall peptidoglycan was meso-diaminopimelic acid, and the whole-cell sugars were galactose, arabinose and glucose. Read More

    Development of a porous 3D graphene-PDMS scaffold for improved osseointegration.
    Colloids Surf B Biointerfaces 2017 Aug 1;159:386-393. Epub 2017 Aug 1.
    ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, NSW 2500, Australia. Electronic address:
    Osseointegration in orthopedic surgery plays an important role for bone implantation success. Traditional treatment of implant surface aimed at improved osseointegration has limited capability for its poor performance in supporting cell growth and proliferation. Polydimethylsiloxane (PDMS) is a widely used silicon-based organic polymer material with properties that are useful in cosmetics, domestic applications and mechanical engineering. Read More

    Consumer exposure to certain ingredients of cosmetic products: The case for tea tree oil.
    Food Chem Toxicol 2017 Aug 14. Epub 2017 Aug 14.
    Ri*QUESTA GmbH, Bandengraben 3, 79331 Teningen, Germany. Electronic address:
    Reliable exposure data are essential to evaluate the safety of ingredients in cosmetics. The study reported here was carried out on behalf of the Australian Tea Tree Industry Association in order to support safety assessment of TTO in consumer cosmetic products. Data regarding the use of TTO-containing cosmetic products were collected through a web-survey among 2535 qualified users of validated TTO-containing cosmetics in 5 European countries. Read More

    Lipid stabilized Water- Oil Interfaces Studied by Micro Focusing Small Angle X-ray Scattering.
    Langmuir 2017 Aug 17. Epub 2017 Aug 17.
    Water in oil (w/o) simple emulsions are dispersed micro-confined systems which find applications in many areas of advanced materials and biotechnology, such as food industry, drug delivery and cosmetics, to name but a few. In these systems, the structural and chemical properties of the boundary layer at the w/o interface are of paramount importance to determine functionality and stability. Recently, microfluidic methods have emerged as a valuable tool to fabricate monodisperse emulsion droplets. Read More

    Microplastic pollution, a threat to marine ecosystem and human health: a short review.
    Environ Sci Pollut Res Int 2017 Aug 16. Epub 2017 Aug 16.
    Bioremediation and Metabolomics Research Group, Department of Chemistry and Chemical Sciences, School of Physical and Material Sciences, Central University of Himachal Pradesh, TAB, Shahpur, Kangra, Himachal Pradesh, 176206, India.
    Human populations are using oceans as their household dustbins, and microplastic is one of the components which are not only polluting shorelines but also freshwater bodies globally. Microplastics are generally referred to particles with a size lower than 5 mm. These microplastics are tiny plastic granules and used as scrubbers in cosmetics, hand cleansers, air-blasting. Read More

    Cosmetic Analysis Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI).
    Materials (Basel) 2013 Mar 13;6(3):1000-1010. Epub 2013 Mar 13.
    INNOVARE Biomarkers Lab, Medicine and Experimental Surgery Department, School of Medical Sciences, University of Campinas, Campinas 13083-877, Brazil.
    A new "omic" platform-Cosmetomics-that proves to be extremely simple and effective in terms of sample preparation and readiness for data acquisition/interpretation is presented. This novel approach employing Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) for cosmetic analysis has proven to readily identify and quantify compounds of interest. It also allows full control of all the production phases, as well as of the final product, by integration of both analytical and statistical data. Read More

    Green Synthesis, Molecular Characterization and Associative Behavior of Some Gemini Surfactants without a Spacer Group.
    Materials (Basel) 2013 Apr 12;6(4):1506-1519. Epub 2013 Apr 12.
    STEBICEF-Department of Biologic, Chemical and Pharmaceutical Science and Technology, University of Palermo, Viale delle Scienze, P.co d'Orleans II, Pad. 17-I90128 Palermo, Italy.
    A series of new gemini surfactants without a spacer group, disodium 2,3-dialkyl-1,2,3,4-butanetetracarboxylates, were synthesized in a green chemistry context minimizing the use of organic solvents and applying microwaves (MW) when activation energy was required. Once the desired architecture was confirmed by means of the nuclear magnetic resonance technique (¹H-NMR, ¹H-¹H COSY) for all the studied surfactants, the critical micellization concentration was determined by conductance measurements. The diffusion coefficient of micelles formed by the four compounds was characterized using pulsed field gradient (PFG)-NMR. Read More

    Versatile chromatographic method for catechin determination in development of topical formulations containing natural extracts.
    Biomed Chromatogr 2017 Aug 15. Epub 2017 Aug 15.
    Laboratory of Food, Drugs and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
    Catechin is found in several natural sources, as Eugenia dysenterica and Syzygium cumini extracts. Its antioxidant and UV-protective properties suggest a potential use in cosmetic and dermatological formulations. A simple analytical method capable of giving support to experiments performed along the development of topical formulations containing this natural substance (i. Read More

    Adherence to a Gluten-Free Diet: Assessment by Dietician Interview and Serology.
    J Pediatr Gastroenterol Nutr 2017 Aug 11. Epub 2017 Aug 11.
    *Department of Pediatrics, University of Colorado, Children's Hospital Colorado, Digestive Health Institute, Aurora, CO †Department of Biostatistics, University of Colorado, Children's Hospital Colorado, Aurora, CO ‡Department of Clinical Nutrition, Children's Hospital Colorado, Digestive Health Institute, Aurora, CO §Department of Pediatrics, University of Colorado, Children's Hospital Colorado, Digestive Health Institute, Aurora, CO.
    We aimed to 1) determine if tissue transglutaminase autoantibody (tTG) positivity was associated with dietitian-assessed adherence to a gluten-free diet in pediatric patients with celiac disease and 2) identify areas where adherence falters. We reviewed the records of children with celiac disease who had a standardized evaluation of adherence by a registered dietitian. A negative tTG value was not associated with good adherence (p = NS). Read More

    What is new in the pathophysiology of acne, an overview.
    J Eur Acad Dermatol Venereol 2017 Sep;31 Suppl 5:8-12
    Department of Dermatology, Nantes University, Nantes, France.
    Acne is a chronic inflammatory disease of the pilosebaceous unit. Its pathophysiology includes hyperseborrhoea, abnormal follicular keratinization and Propionibacterium acnes proliferation in the pilosebaceous unit. Recent research has shed some new light on the involvement of the sebaceous gland, as well as on the pro-inflammatory activity of the cutaneous microbiome. Read More

    Fragility of epidermis: acne and post-procedure lesional skin.
    J Eur Acad Dermatol Venereol 2017 Sep;31 Suppl 6:3-18
    A-DERMA, Pierre Fabre Dermo-Cosmétique, Lavaur, France.
    'Fragile skin', or skin with lower resistance to aggressors, can be broadly classified into four causal categories: constitutional (age-dependent or associated with specific vulnerable locations on the body, e.g. eyelids), pathological (related to disease), circumstantial (related to environmental or internal factors, e. Read More

    Coumarin-containing thermoresponsive hyaluronic acid-based nanogels as delivery systems for anticancer chemotherapy.
    Nanoscale 2017 Aug 14. Epub 2017 Aug 14.
    Grenoble Alpes University, CERMAV-CNRS, Grenoble, France.
    Multi-stimuli responsive nanogels based on biocompatible hydrophilic polymers have emerged as promising drug delivery systems to improve anticancer therapy with hydrophobic drugs, through increase of circulating-time in the bloodstream, tumor-targeting and reduction of systemic toxicity. This paper reports on the synthesis, characterization and biological perspectives of light- and thermoresponsive hyaluronic acid (HA)-based nanogels containing coumarin as the photocleavable group. Newly synthesized nanogels exhibited interesting features: formation by a temperature-triggered self-assembly process, successful incorporation of poorly water-soluble molecules, light-responsiveness as demonstrated by a significant shift in the critical aggregation temperature after light irradiation, efficient internalization by cancer cells overexpressing the CD44 receptor of HA, ability to circulate for a prolonged period of time in the bloodstream after intravenous injection in mice and considerable detection in tumor tissues. Read More

    State-of-the-art nanopathological diagnostics.
    Ultrastruct Pathol 2017 Aug 14:1-3. Epub 2017 Aug 14.
    a Department of Diagnostic and Clinical Medicine and of Public Health , University of Modena and Reggio Emilia , Modena , MO , Italy.
    The nanopathological diagnostics (ND) is an ultra-specialized branch of pathological anatomy aimed to identify the nanoparticles of metallic, semimetallic, or nonmetallic elements in the inorganic particulate matter present inside pathological tissues, even on the nanometer scale. ND exploits an environmental scanning electron microscope, connected to an X-ray microprobe mounted on an energy-dispersive spectrometer. The searching of nanoparticles can be performed on paraffin-embedded material, omitting emissions of black overlay and plating procedures. Read More

    Heterotypic Supramolecular Hydrogels.
    J Mater Chem B Mater Biol Med 2016 Sep 26;4(34):5638-5649. Epub 2016 Jul 26.
    415 South Street, MS 015, Waltham, MA 02453, USA.
    Supramolecular hydrogels, formed via intermolecular interactions in water, are emerging as a new type of versatile soft materials to be applied in many areas, such as biomedical applications, catalysis, food additives, and cosmetics. While most of the supramolecular hydrogels are homotypic (i.e. Read More

    Volatile terpenoids: multiple functions, biosynthesis, modulation and manipulation by genetic engineering.
    Planta 2017 Aug 12. Epub 2017 Aug 12.
    The Research Center for Ornamental Plants, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou, 510642, China.
    Main Conclusion: Terpenoids play several physiological and ecological functions in plant life through direct and indirect plant defenses and also in human society because of their enormous applications in the pharmaceutical, food and cosmetics industries. Through the aid of genetic engineering its role can by magnified to broad spectrum by improving genetic ability of crop plants, enhancing the aroma quality of fruits and flowers and the production of pharmaceutical terpenoids contents in medicinal plants. Terpenoids are structurally diverse and the most abundant plant secondary metabolites, playing an important role in plant life through direct and indirect plant defenses, by attracting pollinators and through different interactions between the plants and their environment. Read More

    Synthesis and anticancer properties of ruthenium (II) complexes as potent apoptosis inducers through mitochondrial disruption.
    Eur J Med Chem 2017 Jul 28;139:180-190. Epub 2017 Jul 28.
    School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Guangdong Cosmetics Engineering & Technology Research Center, Guangzhou, 510006, PR China. Electronic address:
    A new ligand MHPIP (MHPIP = 2-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthroline) and its three ruthenium (II) complexes [Ru(N-N)2(MHPIP)](ClO4)2 (N-N = phen: 1,10-phenanthroline 1; dmp = 2,9-dimethyl-1,10-phenanthroline 2; ttbpy = 4,4'-ditertiarybutyl-2,2'-bipyridine 3) were synthesized and characterized. The cytotoxic activity in vitro was studied by MTT method. The complexes 1-3 show moderate cytotoxic effects on the cell growth in HepG2 cells with an IC50 value of 25. Read More

    Nucleation in food colloids.
    J Chem Phys 2016 Dec;145(21):211906
    School of Food Science and Nutrition, The University of Leeds, Leeds LS2 9JT, United Kingdom.
    Nucleation in food colloids has been studied in detail using ultrasound spectroscopy. Our data show that classical nucleation theory (CNT) remains a sound basis from which to understand nucleation in food colloids and analogous model systems using n-alkanes. Various interpretations and modifications of CNT are discussed with regard to their relevance to food colloids. Read More

    Fragrance contact allergens in 5,588 cosmetic products identified through a novel smartphone application.
    J Eur Acad Dermatol Venereol 2017 Aug 10. Epub 2017 Aug 10.
    National Allergy Research Centre Department of Dermatology and Allergy, Herlev-Gentofte Hospital University of Copenhagen, 2900, Hellerup, Denmark.
    Background: More than 25% of the adult European population suffers from contact allergy, with fragrance substances recognized as one of the main causes. Since 2005, 26 fragrance contact allergens have been mandatory to label in cosmetic products within the EU if present at 10 ppm or above in leave-on and 100 ppm or above in wash-off cosmetics.

    Objective: To examine exposure, based on ingredient labelling, to the 26 fragrances in a sample of 5,588 fragranced cosmetic products. Read More

    The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor.
    BMC Complement Altern Med 2017 Aug 9;17(1):392. Epub 2017 Aug 9.
    Honey Bee Town Co., Ltd., No.77-2 Huaxi, 970, Hualien City, Taiwan.
    Background: It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera.

    Methods: In this study, we assesses the 10-HDA whitening activity in comparison with the changes in the intracellular tyrosinase activity, melanin content and melanin production related protein levles in B16F1 melanoma cells after treating with 10-HDA. Read More

    Facial Contrast Is a Cross-Cultural Cue for Perceiving Age.
    Front Psychol 2017 25;8:1208. Epub 2017 Jul 25.
    Chanel PBPantin, France.
    Age is a fundamental social dimension and a youthful appearance is of importance for many individuals, perhaps because it is a relevant predictor of aspects of health, facial attractiveness and general well-being. We recently showed that facial contrast-the color and luminance difference between facial features and the surrounding skin-is age-related and a cue to age perception of Caucasian women. Specifically, aspects of facial contrast decrease with age in Caucasian women, and Caucasian female faces with higher contrast look younger (Porcheron et al. Read More

    Alcoholic versus aqueous chlorhexidine for skin antisepsis: the AVALANCHE trial.
    CMAJ 2017 Aug;189(31):E1008-E1016
    Discipline of General Practice and Rural Medicine (Charles, Heal, Delpachitra, Wohlfahrt, Hardy, Banks), Mackay Clinical School, College of Medicine and Dentistry, James Cook University, Mackay; Anton Breinl Research Centre for Health Systems Strengthening (Heal), Australian Institute of Tropical Health and Medicine, James Cook University, Townsville; Mackay Institute of Research and Innovation (Heal), Townsville; Paul Hopkins Medical Centre (Kimber, Sullivan), Mackay; Smart Scan Mackay (Browning), Mackay; Mareeba Medical Centre (Saednia), Mareeba; Tropical Health Solutions (Buttner), Townsville; Centre for Chronic Disease Prevention (Buttner), James Cook University, Cairns, Australia.
    Background: Preoperative skin antisepsis is routine practice. We compared alcoholic chlorhexidine with aqueous chlorhexidine for skin antisepsis to prevent surgical site infection after minor skin excisions in general practice.

    Methods: We conducted this prospective, multicentre, randomized controlled trial in 4 private general practices in North Queensland, Australia, from October 2015 to August 2016. Read More

    Review of data on the dermal penetration of mineral oils and waxes used in cosmetic applications.
    Toxicol Lett 2017 Aug 5. Epub 2017 Aug 5.
    Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany.
    Mineral oils and waxes used in cosmetic products, also referred to as "personal care products" outside the European Union, are mixtures of predominantly saturated hydrocarbons consisting of straight-chain, branched and ring structures with carbon chain lengths greater than C16. They are used in skin and lip care cosmetic products due to their excellent skin tolerance as well as their high protecting and cleansing performance and broad viscosity options. Recently, concerns have been raised regarding potential adverse health effects of mineral oils and waxes from dermal application of cosmetics. Read More

    Evaluation of metabolism of azo dyes and their effects on Staphylococcus aureus metabolome.
    J Ind Microbiol Biotechnol 2017 Aug 7. Epub 2017 Aug 7.
    Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd, Jefferson, AR, 72079-9502, USA.
    Dyes containing one or more azo linkages are widely applied in cosmetics, tattooing, food and drinks, pharmaceuticals, printing inks, plastics, leather, as well as paper industries. Previously we reported that bacteria living on human skin have the ability to reduce some azo dyes to aromatic amines, which raises potential safety concerns regarding human dermal exposure to azo dyes such as those in tattoo ink and cosmetic colorant formulations. To comprehensively investigate azo dye-induced toxicity by skin bacteria activation, it is very critical to understand the mechanism of metabolism of the azo dyes at the systems biology level. Read More

    Image-based haptic roughness estimation and rendering for haptic palpation from in vivo skin image.
    Med Biol Eng Comput 2017 Aug 8. Epub 2017 Aug 8.
    Department of Information and Telecommunication Engineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon, 22012, South Korea.
    Despite the advancement of measuring technologies, there was a need for palpation by hands to be able to better diagnose skin diseases and to learn about the tactile properties of in vivo skin surface. However, directly touching in vivo skin surface can cause secondary infections or damages. Therefore, a technology providing infection- and damage-free skin palpations and precise haptic skin roughness rendering is needed. Read More

    Impact of polyethylene microbeads on the floating freshwater plant duckweed Lemna minor.
    Environ Pollut 2017 Aug 2;230:1108-1115. Epub 2017 Aug 2.
    University of Ljubljana, Biotechnical Faculty, 111 Večna pot, SI-1000 Ljubljana, Slovenia.
    Microplastics (MP), small plastic particles below 5 mm, have become one of the central concerns of environmental risk assessment. Microplastics are continuously being released into the aquatic environment either directly through consumer products or indirectly through fragmentation of larger plastic materials. The aim of our study was to investigate the effect of polyethylene microbeads from cosmetic products on duckweed (Lemna minor), a freshwater floating plant. Read More

    Ecotoxicological modelling of cosmetics for aquatic organisms: A QSTR approach.
    SAR QSAR Environ Res 2017 Jul 7;28(7):567-594. Epub 2017 Aug 7.
    b Drug Theoretics and Cheminformatics Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology , Jadavpur University , Kolkata , India.
    In this study, externally validated quantitative structure-toxicity relationship (QSTR) models were developed for toxicity of cosmetic ingredients on three different ecotoxicologically relevant organisms, namely Pseudokirchneriella subcapitata, Daphnia magna and Pimephales promelas following the OECD guidelines. The final models were developed by partial least squares (PLS) regression technique, which is more robust than multiple linear regression. The obtained model for P. Read More

    Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice.
    Chem Biol Interact 2017 Aug 2;275:133-144. Epub 2017 Aug 2.
    Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang, China.
    Titanium dioxide nanoparticles (TiO2 NPs) are widely used to additives in cosmetics, pharmaceuticals, paints and foods. Recent studies have demonstrated that TiO2 NPs increased the risk of cancer and the mechanism might relate with oxidative stress. Grape seed procyanidin extract (GSPE) is a natural compound which has been demonstrated to possess a wide array of pharmacological and biochemical actions, including anti-inflammatory, anti-carcinogenic, and antioxidant properties. Read More

    Evaluation of ocular irritancy of coal-tar dyes used in cosmetics employing reconstructed human cornea-like epithelium and short time exposure tests.
    Food Chem Toxicol 2017 Aug 3;108(Pt A):236-243. Epub 2017 Aug 3.
    College of Pharmacy, Ewha Womans University, Seoul 37060, Republic of Korea. Electronic address:
    Coal-tar dyes in cosmetics may elicit adverse effects in the skin and eyes. Countries, like the US, have banned the use of coal-tar dyes in cosmetics for the eye area due to the potential for ocular irritation. We evaluated the eye irritation potential of 15 coal-tar dyes permitted as cosmetic ingredients in reconstructed human cornea-like epithelium (RhCEs [EpiOcular™ and MCTT HCE™]) tests and the short time exposure (STE) test. Read More

    Assessment of Genetic Diversity and Structure of Large Garlic (Allium sativum) Germplasm Bank, by Diversity Arrays Technology "Genotyping-by-Sequencing" Platform (DArTseq).
    Front Genet 2017 20;8:98. Epub 2017 Jul 20.
    Departamento de Bioquímica y Biología Molecular, Campus Rabanales (C6-1-E17), Campus de Excelencia Internacional Agroalimentario (ceiA3), Universidad de CórdobaCórdoba, Spain.
    Garlic (Allium sativum) is used worldwide in cooking and industry, including pharmacology/medicine and cosmetics, for its interesting properties. Identifying redundancies in germplasm blanks to generate core collections is a major concern, mostly in large stocks, in order to reduce space and maintenance costs. Yet, similar appearance and phenotypic plasticity of garlic varieties hinder their morphological classification. Read More

    The chlorination transformation characteristics of benzophenone-4 in the presence of iodide ions.
    J Environ Sci (China) 2017 Aug 3;58:93-101. Epub 2017 May 3.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
    Benzophenone-type UV filters are a group of compounds widely used to protect human skin from damage of UV irradiation. Benzophenone-4 (BP-4) was targeted to explore its transformation behaviors during chlorination disinfection treatment in the presence of iodide ions. With the help of ultra performance liquid phase chromatograph and high-resolution quadrupole time-of-flight mass spectrometer, totally fifteen halogenated products were identified, and five out of them were iodinated products. Read More

    Occurrence and formation of disinfection by-products in the swimming pool environment: A critical review.
    J Environ Sci (China) 2017 Aug 24;58:19-50. Epub 2017 Jun 24.
    Curtin Water Quality Research Centre, Department of Chemistry, Curtin University, Perth, Western Australia 6102, Australia. Electronic address:
    Disinfection of water for human use is essential to protect against microbial disease; however, disinfection also leads to formation of disinfection by-products (DBPs), some of which are of health concern. From a chemical perspective, swimming pools are a complex matrix, with continual addition of a wide range of natural and anthropogenic chemicals via filling waters, disinfectant addition, pharmaceuticals and personal care products and human body excretions. Natural organic matter, trace amounts of DBPs and chlorine or chloramines may be introduced by the filling water, which is commonly disinfected distributed drinking water. Read More

    Cellular and Molecular Targets of Menthol Actions.
    Front Pharmacol 2017 18;8:472. Epub 2017 Jul 18.
    Department of Health Sciences, College of Natural and Health Sciences, Zayed UniversityAbu Dhabi, United Arab Emirates.
    Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Read More

    Synthesis of Five and Six-Membered Heterocycles Using Activated Nitriles for Industrial Applications.
    J Oleo Sci 2017 ;66(8):925-938
    Biology Department, College of Applied Sciences,Umm Al-Qura University.
    The aim of this study is a synthesis of new bioactive heterocyclic compounds incorporated fatty chain for use in different industrial applications. Cyanoacetamide derivative (2) was successfully transferred into five and six membered heterocyclic derivatives by the reaction with various chemical reagents. Addition number of moles of propylene oxide to these compounds gave nonionic surface-active agents having a good solubility, biodegradability and hence lowers the toxicity to human beings and becomes environmentally friendly. Read More

    A simple and fast method for extraction and quantification of cryptophyte phycoerythrin.
    MethodsX 2017 28;4:209-213. Epub 2017 Jun 28.
    Roskilde University, Department for Science and Environment, Universitetsvej 1, Postbox 260, Building 11.2, DK-4000 Roskilde, Denmark.
    The microalgal pigment phycoerythrin (PE) is of commercial interest as natural colorant in food and cosmetics, as well as fluoroprobes for laboratory analysis. Several methods for extraction and quantification of PE are available but they comprise typically various extraction buffers, repetitive freeze-thaw cycles and liquid nitrogen, making extraction procedures more complicated. A simple method for extraction of PE from cryptophytes is described using standard laboratory materials and equipment. Read More

    Structural and functional analyses of a TIMP and MMP in the ligament of Pinctada fucata.
    J Struct Biol 2017 Jul 29. Epub 2017 Jul 29.
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. Electronic address:
    The bivalve hinge ligament is the hard tissue that functions to open and close shells. The ligament contains fibrous structures consisting of aragonite crystals surrounded by a dense organic matrix. This organic matrix may contribute to the formation of fibrous aragonite crystals, but the mechanism underlying this formation remains unclear. Read More

    Electrochemical behaviour at a liquid-organogel microinterface array of fucoidan extracted from algae.
    Analyst 2017 Aug;142(17):3194-3202
    Curtin Institute of Functional Molecules and Interfaces, Department of Chemistry, Curtin University, GPO Box U1987, Perth, WA 6845, Australia.
    Fucoidans are sulfated polysaccharides mostly derived from algae and used in a number of applications (e.g. nutrition, cosmetics, pharmaceuticals and biomaterials). Read More

    A QSAR Study Based on SVM for the Compound of Hydroxyl Benzoic Esters.
    Bioinorg Chem Appl 2017 3;2017:4914272. Epub 2017 Jul 3.
    School of Medical Information Engineering, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou 510006, China.
    Hydroxyl benzoic esters are preservative, being widely used in food, medicine, and cosmetics. To explore the relationship between the molecular structure and antibacterial activity of these compounds and predict the compounds with similar structures, Quantitative Structure-Activity Relationship (QSAR) models of 25 kinds of hydroxyl benzoic esters with the quantum chemical parameters and molecular connectivity indexes are built based on support vector machine (SVM) by using R language. The External Standard Deviation Error of Prediction (SDEPext), fitting correlation coefficient (R(2)), and leave-one-out cross-validation (Q(2)LOO) are used to value the reliability, stability, and predictive ability of models. Read More

    High- and low-Molecular Weight oat Beta-Glucan Reveals Antitumor Activity in Human Epithelial Lung Cancer.
    Pathol Oncol Res 2017 Jul 29. Epub 2017 Jul 29.
    Department of Medical Biochemistry, Wroclaw Medical University, Chalubinskiego 10, 50-368, Wroclaw, Poland.
    Beta-glucans are widely used in treatment, cosmetics, and the food industry. Glucans play a significant role in activation of the immune and antioxidant system and inhibiting tumor proliferation. In the current study the antitumor activities of new high and low molecular weight beta-glucan derived from oats were investigated in two human lung cancer cell line (A549, H69AR) and normal keratinocytes (HaCaT). Read More

    Rapid Estimation of Astaxanthin and the Carotenoid-to-Chlorophyll Ratio in the Green Microalga Chromochloris zofingiensis Using Flow Cytometry.
    Mar Drugs 2017 Jul 19;15(7). Epub 2017 Jul 19.
    Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University Jena, Lessingstr. 8, D-07743 Jena, Germany.
    The green microalga Chromochloris zofingiensis can accumulate significant amounts of valuable carotenoids, mainly natural astaxanthin, a product with applications in functional food, cosmetics, nutraceuticals, and with potential therapeutic value in cardiovascular and neurological diseases. To optimize the production of astaxanthin, it is essential to monitor the content of astaxanthin in algal cells during cultivation. The widely used HPLC (high-performance liquid chromatography) method for quantitative astaxanthin determination is time-consuming and laborious. Read More

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