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    Assessing seasonal variation of synthetic musks in beach sands from Oporto coastal area: A case study.
    Environ Pollut 2017 Apr 18;226:190-197. Epub 2017 Apr 18.
    LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
    Synthetic musk compounds are widely used in the formulation of several cosmetics, personal care and household products. Due to their massive and widespread use, together with some health concerns, they are considered emerging pollutants and have been detected in different environmental compartments. This study focused on the evaluation of the concentration of synthetic musks (five nitro, five polycyclic and one macrocyclic musks) in beach sands, from Oporto coastal area (Portugal), contributing to the enhancement of the knowledge of levels, trends and behaviour of these compounds in this particular matrix. Read More

    Walking a fine line with sucrose phosphorylase: efficient single-step biocatalytic production of L-ascorbic acid 2-glucoside from sucrose.
    Chembiochem 2017 Apr 20. Epub 2017 Apr 20.
    Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12, 8010, Graz, AUSTRIA.
    The 2-O-α-D-glucoside of L-ascorbic acid (AA-2G) is a highly stabilized form of vitamin C, with important applications in cosmetics, foods and pharmaceuticals. Sucrose would be an ideal substrate for AA-2G synthesis, but it cannot be used lacking a suitable transglycosidase. We show that in a narrow pH window with sharp optimum at pH 5. Read More

    Comparative analysis of the expression level of recombinant ginsenoside-transforming β-glucosidase in GRAS hosts and mass production of the ginsenoside Rh2-Mix.
    PLoS One 2017 19;12(4):e0176098. Epub 2017 Apr 19.
    Department of Biotechnology, Hankyoung National University, Kyonggi-do, Republic of Korea.
    The ginsenoside Rh2, a pharmaceutically active component of ginseng, is known to have anticancer and antitumor effects. However, white ginseng and red ginseng have extremely low concentrations of Rh2 or Rh2-Mix [20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3]. To enhance the production of food-grade ginsenoside Rh2, an edible enzymatic bioconversion technique was developed adopting GRAS host strains. Read More

    Common Diaper Ingredient Questions: Modern Disposable Diaper Materials Are Safe and Extensively Tested.
    Clin Pediatr (Phila) 2017 May;56(5_suppl):23S-27S
    2 Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
    Today's disposable diapers are high-performance and well-tested products, designed to keep skin dry and healthy. They are primarily made of biologically inert polymers, commonly used in fabrics and other materials that are in contact with skin, and in foods and cosmetics. Still, product safety and ingredients in everyday products can be a source of anxiety for new parents. Read More

    Marine Microbial-Derived Molecules and Their Potential Use in Cosmeceutical and Cosmetic Products.
    Mar Drugs 2017 Apr 12;15(4). Epub 2017 Apr 12.
    Stazione Zoologica Anthon Dohrn, 80121 Naples, Italy.
    The oceans encompass a wide range of habitats and environmental conditions, which host a huge microbial biodiversity. The unique characteristics of several marine systems have driven a variety of biological adaptations, leading to the production of a large spectrum of bioactive molecules. Fungi, fungi-like protists (such as thraustochytrids) and bacteria are among the marine organisms with the highest potential of producing bioactive compounds, which can be exploited for several commercial purposes, including cosmetic and cosmeceutical ones. Read More

    [The Jardé law, a real simplification of research in France?]
    Arch Pediatr 2017 Apr 14. Epub 2017 Apr 14.
    Clinical research center (CRC), centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil, France; Service de pédiatrie, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil, France.
    The Jardé law was voted in 2012 and its implementing decrees were published in November 2016. The delay between the vote and the decrees highlights the difficulties encountered. This law concerns all research, interventional and otherwise, involving the human person. Read More

    Application of Deep Eutectic Solvents (DES) for phenolic compounds extraction: overview, challenges, and opportunities.
    J Agric Food Chem 2017 Apr 17. Epub 2017 Apr 17.
    The green chemistry era has pushed the scientific community to investigate and implement new solvents in the phenolic compounds (PC) extraction, as alternative to the organic solvents which are toxic and may be dangerous. Recently, Deep Eutectic Solvents (DES) have been applied as extraction solvents of PC. They have the advantages to be biodegradable, easy to handle with very low toxicity. Read More

    Chemical toxicity prediction for major classes of industrial chemicals: Is it possible to develop universal models covering cosmetics, drugs, and pesticides?
    Food Chem Toxicol 2017 Apr 12. Epub 2017 Apr 12.
    Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA. Electronic address:
    Computational models have earned broad acceptance for assessing chemical toxicity during early stages of drug discovery or environmental safety assessment. The majority of publicly available QSAR toxicity models have been developed for datasets including mostly drugs or drug-like compounds. We have evaluated and compared chemical spaces occupied by cosmetics, drugs, and pesticides, and explored whether current computational models of toxicity endpoints can be universally applied to all these chemicals. Read More

    [Watching dance of the molecules - CARS microscopy].
    Postepy Biochem 2017 ;63(1):44-52
    Molecular Biotechnology Laboratory, Bionanopark Sp. z o.o., 114/116 Dubois St., 93-465 Lodz, Poland.
    CARS (Coherent Anti-Stokes Raman Scattering) microscopy is an imaging method for living cells visualization as well as for food or cosmetics material analysis without the need for staining. The near infrared laser source generates the CARS signal - the characteristic intrinsic vibrational contrast of the molecules in a sample which is no longer caused by staining, but by the molecules themselves. It provides the benefit of a non-toxic, non-destructive and almost noninvasive method for sample imaging. Read More

    Negatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations.
    Int J Nanomedicine 2017 31;12:2517-2530. Epub 2017 Mar 31.
    Nanobiolab, Department of Biotechnology and Bioscience, University of Milano-Bicocca.
    Background: The discovery of new solutions with antibacterial activity as efficient and safe alternatives to common preservatives (such as parabens) and to combat emerging infections and drug-resistant bacterial pathogens is highly expected in cosmetics and pharmaceutics. Colloidal silver nanoparticles (NPs) are attracting interest as novel effective antimicrobial agents for the prevention of several infectious diseases.

    Methods: Water-soluble, negatively charged silver nanoparticles (AgNPs) were synthesized by reduction with citric and tannic acid and characterized by transmission electron microscopy, dynamic light scattering, zeta potential, differential centrifuge sedimentation, and ultraviolet-visible spectroscopy. Read More

    Lead Exposure Assessment among Pregnant Women, Newborns, and Children: Case Study from Karachi, Pakistan.
    Int J Environ Res Public Health 2017 Apr 13;14(4). Epub 2017 Apr 13.
    Department of Environmental and Preventive Medicine, School of Medicine, Jichi Medical University, Shimotsuke 329-0498, Japan.
    Lead (Pb) in petrol has been banned in developed countries. Despite the control of Pb in petrol since 2001, high levels were reported in the blood of pregnant women and children in Pakistan. However, the identification of sources of Pb has been elusive due to its pervasiveness. Read More

    Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signaling pathways.
    Br J Dermatol 2017 Apr 12. Epub 2017 Apr 12.
    IEB-Lucas Meyer Cosmetics, 31520, Ramonville, France.
    Background: Male androgenetic alopecia (AGA) is the most common form of hair loss in men and is characterized by a distinct pattern of progressive hair loss starting from the frontal area and the vertex of the scalp. Although several genetic risk loci have been identified, relevant genes for AGA remain to be defined.

    Objectives: Herein, molecular biomarkers associated with premature AGA were identified through gene expression analysis using cDNA generated from scalp vertex biopsies of hairless/bald men with premature AGA and healthy volunteers. Read More

    Investigating the Origins of Toxic Response in TiO₂ Nanoparticle-Treated Cells.
    Nanomaterials (Basel) 2017 Apr 11;7(4). Epub 2017 Apr 11.
    Department of Genetics and Bioengineering, Yeditepe University, 34755 Atasehir, Istanbul, Turkey.
    Titanium dioxide nanoparticles (TiO₂ NPs) are widely used in sunscreens, cosmetics and body implants, and this raises toxicity concerns. Although a large number of reports claim that they are safe to use, others claim that they induce reactive oxygen species formation and can be carcinogenic. In this study, the origins of toxic response to TiO₂ NPs were investigated by using Surface-enhanced Raman spectroscopy (SERS) which provides multidimensional information on the cellular dynamics at single cell level without any requirement for cell fixation. Read More

    Knowledge and Behavior Regarding Cosmetics in Koreans Visiting Dermatology Clinics.
    Ann Dermatol 2017 Apr 24;29(2):180-186. Epub 2017 Mar 24.
    Arumdaun Nara Clinic, Seoul, Korea.
    Background: Cosmetics can affect the skin condition profoundly, and yet no survey has been performed in Koreans visiting dermatology clinics.

    Objective: To assess knowledge and consumer behavior regarding cosmetics in Koreans visiting dermatology clinics.

    Methods: A questionnaire consisting of 43 questions concerning demographics and use/knowledge/selection/purchase of cosmetics was given to patients and accompanying persons who visited dermatologic clinics in university and private clinic settings. Read More

    Anti-inflammatory, antimycobacterial and genotoxic evaluation of Doliocarpus dentatus.
    J Ethnopharmacol 2017 Apr 6. Epub 2017 Apr 6.
    School of Health Sciences, Federal University of Grande Dourados - Dourados, Mato Grosso do Sul State, Brazil. Electronic address:
    Ethnopharmacological Relevance: Doliocarpus dentatus is a medicinal plant widely used in Mato Grosso do Sul State for removing the swelling pain caused by the inflammation process and for treating urine retention.

    Aim Of The Study: The genotoxic aspects and the anti-inflammatory and antimycobacterial activity of the ethanolic extract obtained from the leaves of D. dentatus (EEDd) were investigated. Read More

    Acute toxicity variation of hydroxyl benzophenone UV filters during photoinduction-chlorination disinfection processes.
    J Environ Sci (China) 2017 Apr 30;54:48-55. Epub 2016 Jun 30.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
    Benzophenones (BPs), a group of widely used UV filters, exert multiple, significant toxicity effects. The 11 BPs were selected as target compounds, and the photobacterium acute toxicity test and an index for acute toxicity formation potential (ATFP) were used to evaluate the toxicity variation of BPs before and after a photoinduction-chlorination disinfection process. Orthogonal experiments were performed at different pH values and chlorine dosages. Read More

    Effects of synthesis methods on catalytic activities of CoOx-TiO2 for low-temperature NH3-SCR of NO.
    J Environ Sci (China) 2017 Apr 11;54:277-287. Epub 2016 Nov 11.
    School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. Electronic address:
    A series of cobalt doped TiO2 (Co-TiO2) and CoOx loaded TiO2 (Co/TiO2) catalysts prepared by sol-gel and impregnation methods respectively were investigated on selective catalytic reduction with NH3 (NH3-SCR) of NO. It was found that Co-TiO2 catalyst showed more preferable catalytic activity at low temperature range. From characterization results of XRD, TEM, Raman and FT-IR, Co species were proved to be doped into TiO2 lattice by replaced Ti atoms. Read More

    Visible light driven mineralization of spiramycin over photostructured N-doped TiO2 on up conversion phosphors.
    J Environ Sci (China) 2017 Apr 27;54:268-276. Epub 2016 May 27.
    University of Salerno, Department of Industrial Engineering, Via Giovanni Paolo II 132, 84084 Fisciano, SA, Italy.
    A novel visible light-active photocatalyst formulation (NdT/OP) was obtained by supporting N-doped TiO2 (NdT) particles on up-conversion luminescent organic phosphors (OP). The photocatalytic activity of such catalysts was evaluated for the mineralization process of spiramycin in aqueous solution. The effect of NdT loading in the range 15-60wt. Read More

    Charge transfer between biogenic jarosite derived Fe(3+)and TiO2 enhances visible light photocatalytic activity of TiO2.
    J Environ Sci (China) 2017 Apr 30;54:256-267. Epub 2016 Apr 30.
    Department of Chemical Engineering, Cape Peninsula University of Technology, South Africa. Electronic address:
    In this work, we have shown that mining waste derived Fe(3+) can be used to enhance the photocatalytic activity of TiO2. This will allow us to harness a waste product from the mines, and utilize it to enhance TiO2 photocatalytic waste water treatment efficiency. An organic linker mediated route was utilized to create a composite of TiO2 and biogenic jarosite. Read More

    Influences of anion concentration and valence on dispersion and aggregation of titanium dioxide nanoparticles in aqueous solutions.
    J Environ Sci (China) 2017 Apr 5;54:135-141. Epub 2016 Jul 5.
    College of Environmental Science and Engineering, Hunan University, Changsha, Hunan 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, Hunan 410082, China.
    Dispersion and aggregation of nanoparticles in aqueous solutions are important factors for safe application of nanoparticles. In this study, dispersion and aggregation of nano-TiO2 in aqueous solutions containing various anions were investigated. The influences of anion concentration and valence on the aggregation size, zeta potential and aggregation kinetics were individually investigated. Read More

    Ecotoxicological Evaluation of the UV Filters Ethylhexyl Dimethyl p-Aminobenzoic Acid and Octocrylene Using Marine Organisms Isochrysis galbana, Mytilus galloprovincialis and Paracentrotus lividus.
    Arch Environ Contam Toxicol 2017 Apr 8. Epub 2017 Apr 8.
    Toralla Marine Station (ECIMAT), University of Vigo, 36331, Vigo, Galicia, Spain.
    The growing concern regarding the negative effects of solar radiation on the skin has led to a drastic increase in the use of sunscreens containing in its composition up to 10% of aromatic chemicals, such as ethylhexyl dimethyl p-aminobenzoic acid (OD-PABA) and octocrylene (OC). The objective of this study was to evaluate the toxicity and to assess the environmental risk posed by these two ultraviolet filters, widely used in cosmetics and as plastic additives, in the marine environment. Several ecotoxicological bioassays were performed with three model organisms belonging to different trophic levels: the microalgae Isochrysis galbana, the mussel Mytilus galloprovincialis, and the sea urchin Paracentrotus lividus. Read More

    Preparation and characterization of composites based on the blends of collagen, chitosan and hyaluronic acid with nano-hydroxyapatite.
    Int J Biol Macromol 2017 Apr 5. Epub 2017 Apr 5.
    Nicolaus Copernicus University in Toruń, Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, ul. Gagarina 7, 87-100 Toruń, Poland.
    3D porous composites based on the blend of chitosan, collagen and hyaluronic acid with the addition of nano-hydroxyapatite were prepared. SEM images for the composites were made and the structure was assessed. Mechanical properties were studied using a Zwick&Roell Testing Mashine. Read More

    Serum pharmacokinetics and coagulation aberration induced by sodium dehydroacetate in male and female Wistar rats.
    Sci Rep 2017 Apr 7;7:46210. Epub 2017 Apr 7.
    College of Veterinary Medicine, Yangzhou Universitys, Yangzhou, Jiangsu 225009, PR China.
    Sodium dehydroacetate (Na-DHA) is used as a preservative in food, animal feeds and cosmetics. Severe haemorrhage in organs and prolongation of coagulation factors in Sprague-Dawley rats has been reported upon oral administration of Na-DHA. We investigated alterations in coagulation parameters and serum pharmacokinetics upon Na-DHA administration. Read More

    Methylparaben-induced decrease in collagen production and viability of cultured human dermal fibroblasts.
    J Appl Toxicol 2017 Apr 6. Epub 2017 Apr 6.
    Department of Medical Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-230, Bialystok, Poland.
    Parabens owing to their many advantageous properties are widely applied in cosmetics, food products and pharmaceuticals. However, recent research results have shown that they possess the ability to accumulate in the human body and exert many adverse effects. In this study, the impact of methylparaben (MP) as the most frequently used preservative in cosmetics, on human dermal fibroblasts and collagen production was evaluated. Read More

    Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin.
    Annu Rev Chem Biomol Eng 2017 Mar 24. Epub 2017 Mar 24.
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0100; email:
    Microneedle patches (MNPs) contain arrays of solid needles measuring hundreds of microns in length that deliver drugs and vaccines into skin in a painless, easy-to-use manner. Optimal MNP design balances multiple interdependent parameters that determine mechanical strength, skininsertion reliability, drug delivery efficiency, painlessness, manufacturability, and other features of MNPs that affect their performance. MNPs can be made by adapting various microfabrication technologies for delivery of small-molecule drugs, biologics, and vaccines targeted to the skin, which can have pharmacokinetic and immunologic advantages. Read More

    Real-Time Observation of Hydrogen Peroxide Transport through the Oil Phase in a W/O/W Double Emulsion with Chemiluminescence Emission.
    Langmuir 2017 Apr 4;33(15):3802-3808. Epub 2017 Apr 4.
    Graduate School of Engineering Science, Osaka University , Toyonaka, Osaka 560-8531, Japan.
    The evaluation of the transport rates of hydrophilic substances is important in agricultural and pharmaceutical chemistry and in the cosmetics and food-processing industries. Although there are some estimation methods focusing on the diffusion of the substances through the oil phase of the W/O/W core-shell double emulsions (oil microcapsules), all of them take several hours or days. This long-time measurement has a risk of rupture of the oil microcapsules, which causes significant errors. Read More

    Drying paint: from micro-scale dynamics to mechanical instabilities.
    Philos Trans A Math Phys Eng Sci 2017 May;375(2093)
    Max Planck Institute for Dynamics and Self-Organization (MPIDS), 37077 Göttingen, Germany.
    Charged colloidal dispersions make up the basis of a broad range of industrial and commercial products, from paints to coatings and additives in cosmetics. During drying, an initially liquid dispersion of such particles is slowly concentrated into a solid, displaying a range of mechanical instabilities in response to highly variable internal pressures. Here we summarize the current appreciation of this process by pairing an advection-diffusion model of particle motion with a Poisson-Boltzmann cell model of inter-particle interactions, to predict the concentration gradients in a drying colloidal film. Read More

    Direct and indirect effects of silver nanoparticles on freshwater and marine microalgae (Chlamydomonas reinhardtii and Phaeodactylum tricornutum).
    Chemosphere 2017 Mar 30;179:279-289. Epub 2017 Mar 30.
    Department of Ecology and Coastal Management, Institute of Marine Sciences of Andalusia (CSIC), Campus Río S. Pedro, 11510, Puerto Real, Cádiz, Spain.
    The last decade has seen a considerable increase in the use of silver nanoparticles (AgNPs), which are found in many every-day consumer products including textiles, plastics, cosmetics, household sprays and paints. The release of those AgNPs into aquatic environments could be causing ecological damage. In this study we assess the toxicity of AgNPs of different sizes to two species of microalgae, from freshwater and marine environment (Chlamydomonas reinhardtii and Phaeodactylum tricornutum respectively). Read More

    Colony fingerprint for discrimination of microbial species based on lensless imaging of microcolonies.
    PLoS One 2017 3;12(4):e0174723. Epub 2017 Apr 3.
    Division of Biotechnology and Life Science, Institute of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
    Detection and identification of microbial species are crucial in a wide range of industries, including production of beverages, foods, cosmetics, and pharmaceuticals. Traditionally, colony formation and its morphological analysis (e.g. Read More

    Implications of molecular diversity of chitin and its derivatives.
    Appl Microbiol Biotechnol 2017 May 31;101(9):3513-3536. Epub 2017 Mar 31.
    Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India.
    Chitin is a long unbranched polysaccharide, made up of β-1,4-linked N-acetylglucosamine which forms crystalline fiber-like structure. It is present in the fungal cell walls, insect and crustacean cuticles, nematode eggshells, and protozoa cyst. We provide a critical appraisal on the chemical modifications of chitin and its derivatives in the context of their improved efficacy in medical applications without any side effect. Read More

    Hybrid optimal descriptors as a tool to predict skin sensitization in accordance to OECD principles.
    Toxicol Lett 2017 Mar 27. Epub 2017 Mar 27.
    IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, 20156, Via La Masa 19, Milano, Italy.
    Skin sensitization (allergic contact dermatitis) is a widespread problem arising from the contact of chemicals with the skin. The detection of molecular features with undesired effect for skin is complex task owing to unclear biochemical mechanisms and unclearness of conditions of action of chemicals to skin. The development of computational methods for estimation of this endpoint in order to reduce animal testing is recommended (Cosmetics Directive EC regulation 1907/2006; EU Regulation, Regulation, 1223/2009). Read More

    Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.
    Pharmacol Rev 2017 Apr;69(2):200-235
    Department of Biomedical Sciences, University of Padova, Italy (M.P., O.R., C.M.); Neurologic Department, University-Hospital S. Maria della Misericordia, Udine, Italy (R.E.); and Consiglio Nazionale delle Ricerche, Institute of Neuroscience, University of Padova, Italy (C.M.)
    The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel BoNTs are being discovered owing to next generation sequencing, but their biologic and pharmacological properties remain largely unknown. The molecular structure of the large protein complexes that the toxin forms with accessory proteins, which are included in some BoNT type A1 and B1 pharmacological preparations, have been determined. Read More

    Micellization in vegetable oils: A structural characterisation.
    Colloids Surf B Biointerfaces 2017 Mar 21;154:279-286. Epub 2017 Mar 21.
    Institut de Chimie Separative de Marcoule, UMR 5257 (CEA, CNRS, Université de Montpellier, ENSCM), BP17171, 30207 Bagnols sur Cèze, France. Electronic address:
    The solubilisation of polar and polyphenol antioxidant in vegetable oils was studied. It was shown that the use of a polyglyceryl-3-diisostearate (PG3DS), a bio-sourced emulsifier well known in cosmetics, increases the yield of solubilisation thanks to some aggregation properties analysed using x-ray scattering technique. We show indeed that PG3DS forms reverse aggregates with a critical concentration that depends on the oil polarity. Read More

    Anti‑wrinkle effect of fermented black ginseng on human fibroblasts.
    Int J Mol Med 2017 Jan 16. Epub 2017 Jan 16.
    Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, Chungnam 31116, Republic of Korea.
    Fermented black ginseng (FBG) is processed by the repeated steaming and drying of fresh ginseng followed by fermentation with Saccharomyces cerevisiae. It is known to possess anti‑oxidative effects. Skin wrinkle formation is associated with oxidative stress and inflammatory reactions. Read More

    Effect of Size and Surface Charge of Gold Nanoparticles on their Skin Permeability: A Molecular Dynamics Study.
    Sci Rep 2017 Mar 28;7:45292. Epub 2017 Mar 28.
    Physical Science Research Area, TCS Research, Tata Research Development and Design Centre, Tata Consultancy Services, 54B, Hadapsar Industrial Estate, Pune - 411013, India.
    Molecular level understanding of permeation of nanoparticles through human skin establishes the basis for development of novel transdermal drug delivery systems and design and formulation of cosmetics. Recent experiments suggest that surface coated nano-sized gold nanoparticles (AuNPs) can penetrate the rat and human skin. However, the mechanisms by which these AuNPs penetrate are not well understood. Read More

    Dermasence refining gel modulates pathogenetic factors of rosacea in vitro.
    J Cosmet Dermatol 2017 Mar 27. Epub 2017 Mar 27.
    P&M Cosmetics GmbH & Co. KG, Münster, Germany.
    Background: Over the counter cosmetics sold for local treatment of slight to moderate rosacea often state the claim of actively modulating rosacea pathogenesis. Factors involved in the pathogenesis of this common yet complex skin disorder include kallikrein-related peptidase 5 (KLK5), LL-37, as well as protease-activated receptor 2 (PAR2) and vascular endothelial growth factor (VEGF).

    Objective: The objective was to prove the modulating effect of the cosmetic skin care agent Dermasence Refining Gel (DRG) on factors involved in rosacea pathogenesis. Read More

    Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways.
    Pulm Pharmacol Ther 2017 Mar 24. Epub 2017 Mar 24.
    Institute of Respiratory Disease, The First Hospital of China Medical University, Shenyang 110001, China. Electronic address:
    Objective: Ursolic acid (UA) is widely distributed in natural plants to against oxidation, virus, inflammation, tumor, and has been widely used in the pharmaceutical and cosmetics. However, its effect on emphysema of chronic obstructive pulmonary disease (COPD) is unknown. Unfolded protein response is involved in pathogenesis of COPD through PERK pathway. Read More

    Antimicrobial activity of eugenol and essential oils containing eugenol: A mechanistic viewpoint.
    Crit Rev Microbiol 2017 Mar 27:1-22. Epub 2017 Mar 27.
    h Faculty of Nutrition Science and Food Technology , National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
    Eugenol is a hydroxyphenyl propene, naturally occurring in the essential oils of several plants belonging to the Lamiaceae, Lauraceae, Myrtaceae, and Myristicaceae families. It is one of the major constituents of clove (Syzygium aromaticum (L.) Merr. Read More

    Rattusin structure reveals a novel defensin scaffold formed by intermolecular disulfide exchanges.
    Sci Rep 2017 Mar 27;7:45282. Epub 2017 Mar 27.
    Department of Chemistry, Chonnam National University, Gwangju 61186, South Korea.
    Defensin peptides are essential for innate immunity in humans and other living systems, as they provide protection against infectious pathogens and regulate the immune response. Here, we report the solution structure of rattusin (RTSN), an α-defensin-related peptide, which revealed a novel C2-symmetric disulfide-linked dimeric structure. RTSN was synthesized by solid-phase peptide synthesis (SPPS) and refolded by air oxidation in vitro. Read More

    Green microparticles based on a chitosan/lactobionic acid/linoleic acid association. Characterisation and evaluation as a new carrier system for cosmetics.
    J Microencapsul 2017 Apr 16:1-11. Epub 2017 Apr 16.
    a Laboratoire des IMRCP, Université Paul Sabatier , Toulouse , France.
    The association chitosan/linoleic acid/lactobionic acid in aqueous solution spontaneously led to the formation of stable microparticles with a liquid hydrophobic core consisting of linoleic acid surrounded by a shell of chitosan/lactobionic acid. The originality of the microparticles arises from the fact that they are formed by the association of three ingredients of cosmetic interest, including a skin penetration enhancer (linoleic acid). Dynamic light scattering (DLS) measurements showed microparticles with a mean diameter of 1-2 μm. Read More

    Inhibition of Malassezia globosa carbonic anhydrase with phenols.
    Bioorg Med Chem 2017 May 18;25(9):2577-2582. Epub 2017 Mar 18.
    Università degli Studi di Firenze, Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, via Ugo Schiff 6, I-50019 Sesto Fiorentino, Firenze, Italy. Electronic address:
    A panel of 22 phenols was investigated as inhibitors of the β-class carbonic anhydrase (CAs, EC 4.2.1. Read More

    Unique Techniques or Approaches in Microvascular and Microlymphatic Surgery.
    Clin Plast Surg 2017 Apr 9;44(2):403-414. Epub 2017 Feb 9.
    Department of Plastic Surgery, Hospital de la Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí 89, Barcelona 08026, Spain.
    Several methods can be used for identifying tissues for transfer in donor-site-depleted patients. A fillet flap can be temporarily stored in other parts of the body and transferred back to the site of tissue defect, including covering the amputated stump of the lower extremity. Human arm transplant is rare and has some unique concerns for the surgery and postsurgical treatment. Read More

    High-efficient n-butanol production by co-culturing Clostridium acetobutylicum and Saccharomyces cerevisiae integrated with butyrate fermentative supernatant addition.
    World J Microbiol Biotechnol 2017 Apr 23;33(4):76. Epub 2017 Mar 23.
    School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian, 223003, China.
    Butanol is not only an important chemical intermediate and solvent in pharmaceutical and cosmetics industries, but also considered as an advanced biofuel. Although species of the natural host Clostridium have been engineered, butanol titers in the anaerobe seem to be limited by its intolerance to butanol less than 13 g/L. Here we aimed to develop a technology for enhancing butanol production by a co-culture system with butyrate fermentative supernatant addition. Read More

    Biotransformation of 2,4-toluenediamine in human skin and reconstructed tissues.
    Arch Toxicol 2017 Mar 23. Epub 2017 Mar 23.
    Institute of Pharmacy (Pharmacology and Toxicology), Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Germany.
    Reconstructed human epidermis (RHE) is used for risk assessment of chemicals and cosmetics and RHE as well as reconstructed human full-thickness skin (RHS) become important for e.g., the pre-clinical development of drugs. Read More

    Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface.
    Oxid Med Cell Longev 2017 28;2017:3708048. Epub 2017 Feb 28.
    Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Penang, Malaysia.
    Cell growth and proliferative activities on titania nanotube arrays (TNA) have raised alerts on genotoxicity risk. Present toxicogenomic approach focused on epithelial HT29 cells with TNA surface. Fledgling cell-TNA interaction has triggered G0/G1 cell cycle arrests and initiates DNA damage surveillance checkpoint, which possibly indicated the cellular stress stimuli. Read More

    Antioxidant and Anti-tyrosinase Activities of Phenolic Extracts from Rape Bee Pollen and Inhibitory Melanogenesis by cAMP/MITF/TYR Pathway in B16 Mouse Melanoma Cells.
    Front Pharmacol 2017 9;8:104. Epub 2017 Mar 9.
    Yunnan Institute of Food Safety, Kunming University of Science and Technology Kunming, China.
    Rape bee pollen possesses many nutritional and therapeutic properties because of its abundant nutrimental and bioactive components. In this study, free (FPE) and bound (BPE) phenolic extracts of rape bee pollen were obtained, phenolic and flavonoid contents were determined, and composition of phenolic acids was analyzed. In vitro antioxidant and anti-tyrosinase (TYR) activities of FPE and BPE were compared, and inhibitory melanogenesis of FPE was further evaluated. Read More

    Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells.
    Nanomaterials (Basel) 2017 Jan 13;7(1). Epub 2017 Jan 13.
    Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Waehringer Strasse 38, 1090 Vienna, Austria.
    Nanostructured silica particles are commonly used in biomedical and biotechnical fields, as well as, in cosmetics and food industry. Thus, their environmental and health impacts are of great interest and effects after oral uptake are only rarely investigated. In the present study, the toxicological effects of commercially available nano-scaled silica with a nominal primary diameter of 12 nm were investigated on the human gastric carcinoma cell line GXF251L. Read More

    Reproductive toxicity provoked by titanium dioxide nanoparticles and the ameliorative role of Tiron in adult male rats.
    Biochem Biophys Res Commun 2017 Apr 20;486(2):595-600. Epub 2017 Mar 20.
    Toxicology and Forensic Medicine Department, Faculty of Veterinary Medicine, Cairo University, Egypt.
    Titanium dioxide nanoparticles (TDN) are widely used in paints, plastics, ceramics, cosmetics, printing ink, rubber and paper. Tiron is a water soluble metal chelator and antioxidant. This study was designed to investigate the reproductive toxicity of TDN in male albino rats and the ameliorative role of Tiron to minimize such toxic effects. Read More

    Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers.
    Eur J Pharmacol 2017 Mar 19. Epub 2017 Mar 19.
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chu-o-ku, Kobe, Hyogo 650-0017, Japan.
    Astilbin, which is one of polyphenolic compounds isolated from the leaves of Engelhardtia chrysolepis HANCE (Chinese name, huang-qui), is available as the effective component in food and cosmetics because of its anti-oxidant and anti-inflammatory effects. The tight junction (TJ) proteins, which protect the body from foreign substances, are related to adhesion between a cell and a cell. Previously, the enhancement of TJ's functions induced by aglycones of flavonoids has been demonstrated, but the effects of the glycosides such as astilbin have not been observed yet. Read More

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