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    The formation of lipid droplets favors intracellular Mycobacterium leprae survival in SW-10, non-myelinating Schwann cells.
    PLoS Negl Trop Dis 2017 Jun 21;11(6):e0005687. Epub 2017 Jun 21.
    Institute of Hansen's Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Korea.
    Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M. Read More

    Controlling the Photonic Properties of Cholesteric Cellulose Nanocrystal Films with Magnets.
    Adv Mater 2017 Jun 21. Epub 2017 Jun 21.
    Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, Lensfield Road, CB2 1EW, UK.
    The self-assembly of cellulose nanocrystals is a powerful method for the fabrication of biosourced photonic films with a chiral optical response. While various techniques have been exploited to tune the optical properties of such systems, the presence of external fields has yet to be reported to significantly modify their optical properties. In this work, by using small commercial magnets (≈ 0. Read More

    Herbal medicinal products in pregnancy - which data are available?
    Reprod Toxicol 2017 Jun 17. Epub 2017 Jun 17.
    Federal Institute for Drugs and Medical Devices (BfArM), 53175 Bonn, Germany.
    This review aims to highlight recent approaches concerning usage of (traditional) herbal medicinal products in pregnancy and to discuss appropriate strategies to handle limited information. Therefore, published monographs of the Committee on Herbal Medicinal products (HMPC) and selected publicly funded webpages, medicinal handbooks, publications and industry and health care organisations webpages were evaluated. While within the monographs of the HMPC a rather conservative approach could be found (mainly because of lacking nonclinical and/or clinical studies), all other sources display a wide variety of information or assessments, thereby often giving contradictory recommendations. Read More

    The Florence Statement on Triclosan and Triclocarban.
    Environ Health Perspect 2017 Jun 20;125(6):064501. Epub 2017 Jun 20.
    Department of Chemistry, University of California at Berkeley , Berkeley, California, USA.
    The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as in building materials. Based on extensive peer-reviewed research, this statement concludes that triclosan and triclocarban are environmentally persistent endocrine disruptors that bioaccumulate in and are toxic to aquatic and other organisms. Read More

    Calidifontibacter terrae sp. nov., an actinomycete isolated from soil, with potential applications in cosmetics.
    Int J Syst Evol Microbiol 2017 Jun 20. Epub 2017 Jun 20.
    1​Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Gyeonggi-Do 16227, Republic of Korea.
    An aerobic, Gram-stain-positive, oxidase- and catalase-positive, non-motile, non-spore-forming, coccoid, creamish-white-coloured bacterium, designated strain R161T, was isolated from soil in Hwaseong, South Korea. The cell-wall peptidoglycan contained glycine, glutamic acid, alanine, aspartic acid, serine and lysine, and whole-cell sugars were galactose, rhamnose, glucose and ribose. Strain R161T showed antibacterial and enzyme inhibitory activities. Read More

    Evaluation of Cd, Cr, Cu, Ni, and Pb in selected cosmetic products from Jordanian, Sudanese, and Syrian markets.
    Public Health 2017 Jun 16;149:130-137. Epub 2017 Jun 16.
    Jordan University of Science and Technology, Jordan.
    Objectives: There is no sufficient data that evaluate heavy metal content in cosmetic products in Jordan as well as Sudan and Syria. This study aims to assess metal levels which include Cadmium (Cd), Chromium (Cr), Copper (Cu), Nickel (Ni), and Lead (Pb) in cosmetic products. These elements have draft limits because they are identified as potential impurities and are known to be toxic. Read More

    Nootkatone encapsulation by cyclodextrins: Effect on water solubility and photostability.
    Food Chem 2017 Dec 29;236:41-48. Epub 2016 Dec 29.
    Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV, EA 4492), SFR Condorcet FR CNRS 3417, ULCO, F-59140 Dunkerque, France. Electronic address:
    Nootkatone (NO) is a sesquiterpenoid volatile flavor, used in foods, cosmetics and pharmaceuticals, possessing also insect repellent activity. Its application is limited because of its low aqueous solubility and stability; this could be resolved by encapsulation in cyclodextrins (CDs). This study evaluated the encapsulation of NO by CDs using phase solubility studies, Isothermal Titration Calorimetry, Nuclear Magnetic Resonance spectroscopy and molecular modeling. Read More

    Biomechanical evaluation of a novel pedicle screw-based interspinous spacer: A finite element analysis.
    Med Eng Phys 2017 Jun 13. Epub 2017 Jun 13.
    Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan; Orthopaedic Device Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:
    Interspinous spacers have been designed to provide a minimally invasive surgical technique for patients with lumbar spinal stenosis or foraminal stenosis. A novel pedicle screw-based interspinous spacer has been developed in this study, and the aim of this finite element experiment was to investigate the biomechanical differences between the pedicle screw-based interspinous spacer (M-rod system) and the typical interspinous spacer (Coflex-F™). A validated finite element model of an intact lumbar spine was used to analyze the insertions of the Coflex-F™, titanium alloy M-rod (M-Ti), and polyetheretherketone M-rod (M-PEEK), independently. Read More

    Comparison of metrological techniques for evaluation of the impact of a cosmetic product containing hyaluronic acid on the properties of skin surface.
    Biointerphases 2017 Jun 14;12(2):021006. Epub 2017 Jun 14.
    National Institute of Public Health, Centre of Toxicology and Health Safety, Srobarova 48, 100 42 Prague, Czech Republic.
    The aim of this research was to evaluate mutual interchangeability of four principally different biometric instrumental techniques designed for objective measurement of changes in the physical, mechanical, and topographical properties of the skin surface treated with commercial antiaging cosmetic products with hyaluronic acid. The following instrumental devices were used: Visioscope PC 35, Corneometer Multiprobe Adapter MPA 6, Reviscometer RVM 600, and 3D scanner Talysurf CLI 500. The comparison of the individual methods was performed using cluster analysis. Read More

    Contact Sensitization Due to Allergens in Nail Cosmetics: Identification, Treatment, and Prevention.
    Dermatitis 2017 Jun 13. Epub 2017 Jun 13.
    From the *Icahn School of Medicine at Mount Sinai; and †Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.
    Ingredients found in the nail cosmetic industry, including but not limited to methacrylate and acrylate monomers, formaldehyde, and toluene sulfonamide-formaldehyde resin, can incite allergic contact dermatitis. An eczematous outbreak presents on areas surrounding the nail plate and may spread through contact transfer of the allergen, commonly to the face and neck. Even components that were originally deemed nonsensitizing, such as the ubiquitous cyanoacrylate adhesive family, have been found to be allergenic. Read More

    Positive Patch-Test Reactions to Essential Oils in Consecutive Patients: Results From North America and Central Europe.
    Dermatitis 2017 Jun 13. Epub 2017 Jun 13.
    From the *Department of Dermatology, Minneapolis Veterans Affairs Medical Center; †HCMC Parkside Occupational and Contact Dermatitis Clinic; and ‡Department of Dermatology, University of Minnesota Medical School, Minneapolis; §Dartmouth-Hitchcock Medical Center, Lebanon, NH; ∥Department of Dermatology, Columbia University Medical Center, New York, NY; ¶University of Louisville, KY; #Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario; and **Division of Dermatology, Montreal General Hospital, McGill University, Quebec, Canada; ††Department of Dermatology, University of California, San Francisco; ‡‡Department of Dermatology, University of Cincinnati, OH; §§Department of Dermatology, Keck School of Medicine, Los Angeles, CA; ∥∥Department of Dermatology, Cleveland Clinic, OH; ¶¶Associates in Dermatology, Fort Myers, FL; ##Department of Dermatology, Pennsylvania State University, State College; ***Division of Dermatology, University of Ottawa, Ontario, Canada; †††Ohio State University, Columbus; and ‡‡‡Information Network of Departments of Dermatology at the University of Gottingen; and §§§Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen-Nuremberg, Germany.
    Background: Synthetic fragrances and natural essential oils (EOs) are used in perfumery and found in various cosmetics. Essential oils are also increasingly used to promote wellness. In previous studies, the sensitization potential of some EOs has been identified; however, the current prevalence of sensitivity is largely unknown. Read More

    Environmental exposure to parabens and sperm chromosome disomy.
    Int J Environ Health Res 2017 Jun 13:1-12. Epub 2017 Jun 13.
    a Department of Environmental Epidemiology , Nofer Institute of Occupational Medicine , Lodz , Poland.
    Parabens are widely used as antimicrobial preservatives in cosmetics, pharmaceuticals, food and beverage processing due to their board spectrum of activity, inertness, and low cost. The study population consisted of 156 men under 45 years of age who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15-300 mln/ml. Participants were interviewed and provided a semen sample. Read More

    Forever young: Visual representations of gender and age in online dating sites for older adults.
    J Women Aging 2017 Jun 13:1-19. Epub 2017 Jun 13.
    a School of Social Work , Bar Ilan University , Ramat Gan , Israel.
    Online dating has become increasingly popular among older adults following broader social media adoption patterns. The current study examined the visual representations of people on 39 dating sites intended for the older population, with a particular focus on the visualization of the intersection between age and gender. All 39 dating sites for older adults were located through the Google search engine. Read More

    Three-phase partitioning as an elegant and versatile platform applied to non-chromatographic bioseparation processes.
    Crit Rev Food Sci Nutr 2017 Jun 13. Epub 2017 Jun 13.
    b The Hong Kong Polytechnic University , Department of Applied Biology & Chemical Technology , State Key Laboratory of Chinese Medicine and Molecular Pharmacology in Shenzhen , Hung Hom , Kowloon , Hong Kong.
    In recent years, a big trend has been the development of rapid, green, efficient, economical, and scalable approaches for the separation and purification of bioactive molecules from natural sources, which can be used in food, cosmetics, and medicine. As a new non-chromatographic bioseparation technology, three-phase partitioning (TPP) is attracting the attention of a growing number of scientists and engineers. Although a number of studies have been published in the last 40 years regarding the extraction, separation, and purification of numerous bioactive molecules using TPP systems, a background review on TPP partitioning fundamentals and its applications is much needed. Read More

    Supplementary dataset for child and adult exposure and health risk evaluation following the use of metal- and metalloid-containing costume cosmetics sold in the United States.
    Data Brief 2017 Aug 4;13:129-131. Epub 2017 May 4.
    Cardno ChemRisk, LLC, 101 2nd Street, Suite 700, San Francisco, CA 94105, United States.
    The data presented in this article are related to the research article entitled "Child and adult exposure and health risk evaluation following the use of metal- and metalloid-containing costume cosmetics sold in the United States" [1]. This article describes the concentration of metals and metalloids contained in various cosmetic products such as body paint, lipstick and eye shadow, the relative percent deviation of two analyses performed on the products and the physico-chemico properties of the metals and metalloids used in the SkinPerm model presented in the aforementioned article. Read More

    Effects of Endocrine-Disrupting Chemicals and Epigenetic Modifications in Ovarian Cancer: A Review.
    Reprod Sci 2017 Jan 1:1933719117711261. Epub 2017 Jan 1.
    2 Dr Deepali Path Labs & Cancer Diagnostic Centre, Bathinda, Punjab, India.
    Ovarian cancer (OC) is a relatively fatal female reproductive malignancy. Since the underlying causes are uncertain, it brings us to believe that both genetic and external factors contribute toward development of this lethal disorder. Exposure to endocrine-disrupting chemicals (EDCs) in the form of occupational usage of pesticides, fungicides, herbicides, plasticizers, cosmetics, and so on is potentially carcinogenic and their ability to cause epigenetic modifications has led us to hypothesize that they may play a catalytic role in OC progression. Read More

    Cell-compatible conducting polyaniline films prepared in colloidal dispersion mode.
    Colloids Surf B Biointerfaces 2017 May 31;157:309-316. Epub 2017 May 31.
    Department of Surface Engineering, Plasma Laboratory, Josef Stefan Institute, 1000 Ljubljana, Slovenia.
    Conducting polyaniline can be prepared and modified using several procedures, all of which can significantly influence its applicability in different fields of biomedicine or biotechnology. The modifications of surface properties are crucial with respect to the possible applications of this polymer in tissue engineering or as biosensors. Innovative technique for preparing polyaniline films via in-situ polymerization in colloidal dispersion mode using four stabilizers (poly-N-vinylpyrrolidone; sodium dodecylsulfate; Tween 20 and Pluronic F108) was developed. Read More

    Polymeric peptide pigments with sequence-encoded properties.
    Science 2017 Jun;356(6342):1064-1068
    Advanced Science Research Center at the Graduate Center of the City University of New York, 85 Saint Nicholas Terrace, New York, NY 10031, USA.
    Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. Read More

    CON4EI: Selection of the reference chemicals for hazard identification and labelling of eye irritating chemicals.
    Toxicol In Vitro 2017 Jun 5. Epub 2017 Jun 5.
    VITO NV (Flemish Institute for Technological Research), Mol, Belgium.
    Assessment of the acute eye irritation potential is part of the international regulatory requirements for testing of chemicals. In the past, several prospective and retrospective validation studies have taken place in the area of serious eye damage/eye irritation testing. Success in terms of complete replacement of the regulatory in vivo Draize rabbit eye test has not yet been achieved. Read More

    Protective effect of Arthrospira platensis extracts against ultraviolet B-induced cellular senescence through inhibition of DNA damage and matrix metalloproteinase-1 expression in human dermal fibroblasts.
    J Photochem Photobiol B 2017 May 31;173:196-203. Epub 2017 May 31.
    Research Institute for Molecular-Targeted Drugs and Department of Cosmetics Engineering, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:
    Ultraviolet (UV) light exposure causes skin photoaging, which is known to be preventable and controllable by application of UV-protective agents. In this study, we demonstrated, for the first time, that the extract of microalgae Arthrospira platensis has a reverse effect on UV-induced photodamage such as loss of cell viability, cellular senescence, DNA damage, and collagen destruction in dermal fibroblasts. Forty-eight extracts were prepared from the cell biomass by controlling culture light conditions, extract solvents, and disruption methods. Read More

    Hyaluronic acid in complexes with surfactants: The efficient tool for reduction of the cytotoxic effect of surfactants on human cell types.
    Int J Biol Macromol 2017 Jun 4;103:1276-1284. Epub 2017 Jun 4.
    Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, alej Svobody 1655/76, Pilsen 323 00 Czech Republic; Institute of Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University in Prague, Ke Karlovu 2, Prague 2, 128 08, Czech Republic. Electronic address:
    The cationic surfactants carbethoxypendecinium bromide (Septonex) and cetyltrimethylammonium bromide (CTAB) are known to be harmful for certain cell types (bacteria, fungi, mammal cells, etc.). Colloidal complexes of these surfactants with negatively-charged hyaluronic acid (HyA) were prepared for potential drug and/or universal delivery applications. Read More

    An Overview of Pickering Emulsions: Solid-Particle Materials, Classification, Morphology, and Applications.
    Front Pharmacol 2017 23;8:287. Epub 2017 May 23.
    School of Pharmacy, Shanghai Jiao Tong UniversityShanghai, China.
    Pickering emulsion, a kind of emulsion stabilized only by solid particles locating at oil-water interface, has been discovered a century ago, while being extensively studied in recent decades. Substituting solid particles for traditional surfactants, Pickering emulsions are more stable against coalescence and can obtain many useful properties. Besides, they are more biocompatible when solid particles employed are relatively safe in vivo. Read More

    Pheophorbide a, a compound isolated from the leaves of Arrabidaea chica, induces photodynamic inactivation of Trypanosoma cruzi.
    Photodiagnosis Photodyn Ther 2017 Jun 3. Epub 2017 Jun 3.
    Post-Graduate Program in Pharmaceutical Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Maringá, Paraná, Brazil; Department of Basic Sciences of Health, State University of Maringá, Maringá, Paraná, Brazil. Electronic address:
    Background: Approximately 6-7 million people are infected with Trypanosoma cruzi, the etiological agent of Chagas' disease. Only two therapeutic compounds have been found to be useful against this disease: nifurtimox and benznidazole. These drugs have been effective in the acute phase of the disease but less effective in the chronic phase; they also have many side effects. Read More

    From Human Mesenchymal Stem Cells to Insulin-Producing Cells: Comparison between Bone Marrow- and Adipose Tissue-Derived Cells.
    Biomed Res Int 2017 11;2017:3854232. Epub 2017 May 11.
    Urology and Nephrology Center, Mansoura, Egypt.
    The aim of this study is to compare human bone marrow-derived mesenchymal stem cells (BM-MSCs) and adipose tissue-derived mesenchymal stem cells (AT-MSCs), for their differentiation potentials to form insulin-producing cells. BM-MSCs were obtained during elective orthotopic surgery and AT-MSCs from fatty aspirates during elective cosmetics procedures. Following their expansion, cells were characterized by phenotyping, trilineage differentiation ability, and basal gene expression of pluripotency genes and for their metabolic characteristics. Read More

    Current status on metabolic engineering for the production of l-aspartate family amino acids and derivatives.
    Bioresour Technol 2017 May 24. Epub 2017 May 24.
    National and Local United Engineering Lab of Metabolic Control Fermentation Technology, Tianjin University of Science and Technology, Tianjin 300457, China; Key Laboratory of Microbial Engineering of China Light Industry, Tianjin University of Science and Technology, Tianjin 300457, China; College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address:
    The l-aspartate amino acids (AFAAs) are constituted of l-aspartate, l-lysine, l-methionine, l-threonine and l-isoleucine. Except for l-aspartate, AFAAs are essential amino acids that cannot be synthesized by humans and most farm animals, and thus possess wide applications in food, animal feed, pharmaceutical and cosmetics industries. To date, a number of amino acids, including AFAAs have been industrially produced by microbial fermentation. Read More

    An evaluation of colloidal and crystalline properties of CaCO3 nanoparticles for biological applications.
    Mater Sci Eng C Mater Biol Appl 2017 Sep 7;78:305-314. Epub 2017 Apr 7.
    Advanced Ceramics, University of Bremen, Am Biologischen Garten 2, 28359 Bremen, Germany; MAPEX - Centre for Materials and Processes, University of Bremen, Bremen 28359, Germany.
    Biodegradable calcium carbonate carriers are a promising and safe nanoparticle platform which might enable various applications as an engineered nanomaterial in health care, food and cosmetics. However, engineered nanoparticles can exhibit new forms of toxicity that must be carefully evaluated before being widely adopted in consumer products or novel drug delivery systems. To this end, we studied four common calcium carbonate particle systems (calcite nanoparticles, amorphous sub-micrometer and vaterite sub-micrometer and micrometer particles) and compared their behavior in biological medium and in cell culture experiments. Read More

    Transplantation of allogeneic adipose-derived mesenchymal stem cells in a cerebral palsy patient.
    Regen Med 2017 Jun 2. Epub 2017 Jun 2.
    BioMimetics Sympathies Inc., 2-4-32 Aomi, Koto-ku, Tokyo, Japan.
    We studied the safety and efficacy of allogeneic human adipose-derived mesenchymal cell (hAMSC) transplantation in a patient with cerebral palsy (CP). The patient received six infusions of allogeneic hAMSCs intravenously, without or with intramuscular or local injections and was followed up for 12 months. Changes in quality of life were assessed using the Short Form 8 health survey questionnaire incorporating physical and mental component summary scores. Read More

    Statistical investigation of extraction parameters of keratin from chicken feather using Design-Expert.
    3 Biotech 2017 Jun 1;7(2):127. Epub 2017 Jun 1.
    Faculty of Computer Systems and Software Engineering, Universiti Malaysia Pahang, Lebuhraya Tun Razak, Gambang, 26300, Kuantan, Pahang Darul Makmur, Malaysia.
    Uncontrolled disposal of feathers from the poultry industry and slaughterhouses is environmentally undesirable. The feathers are composed of approximately 90% of keratin which is an important ingredient of cosmetics, shampoos and hair treatment creams. This study aimed to determine the optimum conditions for the extraction of keratin from chicken feathers. Read More

    Afr J Tradit Complement Altern Med 2017 13;14(2):130-141. Epub 2017 Jan 13.
    Chemistry Department, Faculty of Science and Technology, Al-Quds University, P.O. Box 20002, Jerusalem, Palestine.
    Background: Ephedra is among Palestinian medicinal plants that are traditionally used in folkloric medicine for treating many diseases. Ephedra is known to have antibacterial and antioxidant effects. The goal of this study is to evaluate the antioxidant activity of different extracts from the Ephedra alata plant growing wild in Palestine, and to analyze their phenolic and flavonoid constituents by HPLC/PDA and HPLC/MS. Read More

    Consumption of cosmetic products by the French population. Third part: Product exposure amount.
    Food Chem Toxicol 2017 May 29;106(Pt A):209-222. Epub 2017 May 29.
    Laboratoire des Interactions Epithéliums Neurones, Université Bretagne Loire (UBL), UFR Sciences et Techniques, 6 Av. Victor Le Gorgeu, CS93837, 29238 Brest Cedex 3, France.
    A recent study in France provided valuable data on the frequency and amount of use of cosmetic products (Ficheux et al., 2015, 2016a). The aim of the present study was to generate Product Exposure Amount data, i. Read More

    Patch testing in patients with suspected cosmetic dermatitis: A retrospective study.
    J Cosmet Dermatol 2017 Jun 1. Epub 2017 Jun 1.
    Department of Dermatology and STD, Lady Hardinge Medical College, New Delhi, India.
    Background: Growing use of cosmetics has led to an increase in the incidence of allergic contact dermatitis (ACD) to cosmetics. Patch testing helps to confirm allergy to cosmetics and pinpoint the exact offending allergens.

    Aims And Objectives: The study aimed to find the frequency of positive patch test reactions in cases with suspected ACD to cosmetics, and the common allergens responsible for it. Read More

    Rice Bran Oil: A Versatile Source for Edible and Industrial Applications.
    J Oleo Sci 2017 ;66(6):551-556
    Department of Oils, Oleochemicals and Surfactants Technology, Institute of Chemical Technology.
    Rice bran oil (RBO) is healthy gift generously given by nature to mankind. RBO is obtained from rice husk, a byproduct of rice milling industry and is gaining lot of importance as cooking oil due to presence of important micronutrient, gamma oryzanol. Its high smoke point is beneficial for its use for frying and deep frying of food stuff. Read More

    Formulation and evaluation of a water-in-oil cream containing herbal active ingredients and ferulic acid.
    Clujul Med 2017 25;90(2):212-219. Epub 2017 Apr 25.
    Department of Histology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
    Background And Aims: The main aims of the present study were to formulate an anti-age cream based on vegetal ingredients and ferulic acid and to evaluate the physical characteristics and the efficacy of the cream.

    Methods: The active ingredients were Centella asiatica oil, Spilanthes acmella oil, Zingiber officinale extract and ferulic acid. Formulation 1 (F1) was prepared using glyceryl stearate and Ceteareth-25® as emulsifiers and Formulation 2 (F2) using glyceryl stearate and potassium cetyl phosphate, all other ingredients remaining the same. Read More

    Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model.
    Regul Toxicol Pharmacol 2017 May 27. Epub 2017 May 27.
    The Procter and Gamble Company, Central Product Safety, P&G Technical Centres Ltd., Whitehall Lane, Egham, Surrey TW20 9NW, United Kingdom.
    In order to accurately assess aggregate exposure to a fragrance material in consumers, data are needed on consumer habits and practices, as well as the concentration of the fragrance material in those products. The present study describes the development of Phase 2 Creme RIFM model by expanding the previously developed Phase 1 model to include an additional six product types. Using subject-matching algorithms, the subjects in the Phase 1 Creme RIFM database were paired with subjects in the SUPERB and BodyCare surveys based on age and gender. Read More

    [Transcription factor p53 and skin aging].
    Adv Gerontol 2017 ;30(1):10-16
    Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation;
    The review is devoted to an actual problem of cosmetics in gerontology, one of molecular aspects of skin aging. Cell renewal processes slow down with aging, and the proliferation apoptosis ratio shifts towards cell death. One of the most pivotal apoptotic markers is the transcription factor p53. Read More

    Diethylhexyl phthalate magnifies deposition of (14) C-bisphenol A in reproductive tissues of mice.
    J Appl Toxicol 2017 May 29. Epub 2017 May 29.
    Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
    Endocrine disrupting chemicals are found in diverse common products, including cosmetics, food packaging, thermal receipt paper and plastic containers. This exposes most people in developed countries through ingestion, skin absorption and inhalation. Two ubiquitous endocrine disrupting chemicals, bisphenol A (BPA) and diethylhexyl phthalate (DEHP) can interact in disrupting blastocyst implantation in inseminated females. Read More

    Procoagulant serine glycoprotease from Cucumis sativus L.: action on human fibrinogen and fibrin clot.
    3 Biotech 2017 Jun 29;7(2):96. Epub 2017 May 29.
    Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Science and Technology University, JSS Technical Institutions Campus, Mysuru, Karnataka, 570 006, India.
    Upon examination of the fruit extract of Cucumis sativus L. for its pharmacological benefits, it was previously observed that it has potential proteolytic, fibrinogenolytic and procoagulant activities. These properties can be attributed to the presence of the protease. Read More

    Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics.
    Int J Toxicol 2017 May/Jun;36(1_suppl):17S-56S
    4 Former Director, Cosmetic Ingredient Review, Cosmetic Ingredient Review, Washington, DC, USA.
    The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the product use, formulation, and safety data of 115 amino acid alkyl amides, which function as skin and hair conditioning agents and as surfactants-cleansing agents in personal care products. Safety test data on dermal irritation and sensitization for the ingredients with the highest use concentrations, lauroyl lysine and sodium lauroyl glutamate, were reviewed and determined to adequately support the safe use of the ingredients in this report. The Panel concluded that amino acid alkyl amides are safe in the present practices of use and concentration in cosmetics, when formulated to be nonirritating. Read More

    Safety Assessment of Anthemis nobilis-Derived Ingredients as Used in Cosmetics.
    Int J Toxicol 2017 May/Jun;36(1_suppl):57S-66S
    4 Former Director, Cosmetic Ingredient Review, Washington, DC, USA.
    Anthemis nobilis (Roman chamomile) flower extract, anthemis nobilis flower oil, anthemis nobilis flower powder, and anthemis nobilis flower water are ingredients that function as fragrance ingredients and skin-conditioning agents in cosmetic products. These ingredients are being used at concentrations up to 10% (anthemis nobilis flower water) in cosmetic products. The available data indicate that these 4 ingredients are not irritating or sensitizing. Read More

    Amended Safety Assessment of Isethionate Salts as Used in Cosmetics.
    Int J Toxicol 2017 May/Jun;36(1_suppl):5S-16S
    4 Former Director, Cosmetic Ingredient Review, Washington, DC, USA.
    The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) rereviewed the safety of 12 isethionate salts as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration, when formulated to be nonirritating. These isethionate salts are reported to function mostly as surfactants and cleansing agents in cosmetic products. The Panel reviewed the available animal and clinical data as well as information from previous CIR reports. Read More

    Laponite®: A key nanoplatform for biomedical applications?
    Nanomedicine 2017 May 26. Epub 2017 May 26.
    CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, Funchal, Portugal. Electronic address:
    Laponite® is a synthetic smectite clay that already has many important technological applications, which go beyond the conventional uses of clays in pharmaceutics and cosmetics. In biomedical applications, particularly in nanomedicine, this material holds great potential. Laponite® is a 2-dimensional (2D) nanomaterial composed of disk-shaped nanoscale crystals that have a high aspect ratio. Read More

    Micelles As Delivery System for Cancer Treatment.
    Curr Pharm Des 2017 May 25. Epub 2017 May 25.
    Departments of, Engineering Sciences, Biomedical Engineering Middle East Technical University, Ankara. Turkey.
    Micelles are nanoparticles formed by the self-assembly of amphiphilic block copolymers in certain solvents above concentrations called critical micelle concentration (CMC). Micelles are used in different fields like food, cosmetics, medicine, etc. These nanosized delivery systems are under spotlight in the recent years with new achievements in terms of their in vivo stability, ability to protect entrapped drug, release kinetics, ease of cellular penetration and thereby increased therapeutic efficacy. Read More

    Screening of TiO2 and Au nanoparticles in cosmetics and determination of elemental impurities by multiple techniques (DLS, SP-ICP-MS, ICP-MS and ICP-OES).
    Talanta 2017 Aug 3;171:291-306. Epub 2017 May 3.
    Ultra Trace Analyses Aquitaine UT2A/ADERA, Hélioparc Pau-Pyrénées, 2 avenue du Président Angot, 64053 PAU cedex 9, Pau, France.
    Cosmetics are part of the daily life of most of the people. Thus, a complete characterization of the products we applied in our skin is necessary. In this work, an analytical investigation of a wide variety of cosmetics from the point of view of total element content and metallic nanoparticles (NPs) has been performed. Read More

    Immunofluorescence evaluation of 4-hydroxynonenal and 8-hydroxy-2-deoxyguanosine activation in zebrafish (Daino rerio) larvae brain exposed (microinjected) to propyl gallate.
    Chemosphere 2017 Sep 19;183:252-256. Epub 2017 May 19.
    Department of Aquaculture, Faculty of Fisheries, Atatürk University, TR-25240 Erzurum, Turkey; Fisheries Faculty, Aquatic Biotechnology Laboratory, Atatürk University Erzurum, TR-25240, Turkey. Electronic address:
    Propyl gallate (PG) is a chemical compound obtained by esterification of propanol with gallic acid. Due to its antioxidative properties, it is widely used in cosmetics and pharmaceutical industries as well as to protect the oils in foods such as butter, milk-based desserts, chewing gum, mayonnaise, meat, soups, cereals, spices and seasonings from rancidity. This study has been designed to assessment 8-OHdG and 4-HNE activity, and histopathological changes in the brain tissues of zebrafish larvae, which is a lecithotrophic organism, after 96 h of PG exposure via microinjecting to yolk sac of embryo. Read More

    Allergic contact dermatitis in preservatives: current standing and future options.
    Curr Opin Allergy Clin Immunol 2017 May 25. Epub 2017 May 25.
    Department of Dermatology, Hospital del Mar - Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
    Purpose Of Review: Preservatives are well known skin sensitizers and represent one of the main causes of contact allergy. The purpose of this article is to review the current state of contact sensitization induced by preservatives and point future alternatives for products' preservation.

    Recent Findings: Isothiazolinones currently are the most common preservatives responsible of contact allergy in Europe and in the United States, and although some regulatory interventions have been taken place, the current contact allergy outbreak is not yet under control. Read More

    Novel glycosylated mycosporine-like amino acid, 13-O-(β-galactosyl)-porphyra-334, from the edible cyanobacterium Nostoc sphaericum-protective activity on human keratinocytes from UV light.
    J Photochem Photobiol B 2017 Jul 15;172:102-108. Epub 2017 May 15.
    Division of Life Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan; School of Natural System, College of Science and Engineering, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan; Division of Biological Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
    A UV-absorbing compound was purified and identified as a novel glycosylated mycosporine-like amino acid (MAA), 13-O-β-galactosyl-porphyra-334 (β-Gal-P334) from the edible cyanobacterium Nostoc sphaericum, known as "ge xian mi" in China and "cushuro" in Peru. Occurrence of the hexosylated derivative of shinorine (hexosyl-shinorine) was also supported by LC-MS/MS analysis. β-Gal-P334 accounted for about 86. Read More

    Efficacy of benzalkonium chloride against bioluminescent P. aeruginosa ATCC9027 constructs.
    Biosens Bioelectron 2017 Apr 23;97:8-15. Epub 2017 Apr 23.
    Microbiology, Molecular Biology and Biotechnology Research Group, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, Hertfordshire, UK.
    Whole cell biosensors have been seldom used in the pharmaceutical and cosmetics industries for preservative efficacy testing (PET). According to several pharmacopoeias, preservatives should be tested for microbial activity using traditional viable count techniques; the use of whole cell microbial biosensors potentially provides an alternative, fast, and efficient method. The aim of the study was to assess the applicability of Pseudomonas aeruginosa ATCC9027 and its validated bioluminescent strains for preservative efficacy tests using benzalkonium chloride (BKC). Read More

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