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J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Institute of Physics, University of São Paulo, São Paulo, 05508-090, SP, Brazil.

Background: Essential oils have great interest among the increasing demand for herbal cosmetics in the market. They are natural sources of biologically active ingredients due to the wide application of such compounds as well as their particular chemical composition. Several researches have evaluated the effectiveness of these bioactive ingredients for use in cosmeceuticals, mainly in both hair scalp and shaft hair damage repair. Read More

Amino Acids 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicinal Chemistry and Clinical Pharmacy, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120, Halle (Saale), Germany.

Free amino acids (FAAs), the major constituents of the natural moisturizing factor (NMF), are very important for maintaining the moisture balance of human skin and their deficiency results in dry skin conditions. There is a great interest in the identification and use of nature-based sources of these molecules for such cosmeceutical applications. The objective of the present study was, therefore, to investigate the FAA contents of selected Ethiopian plant and fungi species; and select the best sources so as to use them for the stated purpose. Read More

Biomolecules 2021 May 20;11(5). Epub 2021 May 20.

Biorefining and Advanced Materials Research Center, Scotland's Rural College (SRUC), Edinburgh EH9 3JG, UK.

Currently, there is a strong enduring interest towards obtaining high-value, sustainable bio-based bioactive compounds from natural resources, as there is great demand for these compounds in various market sectors such as agriculture, food, pharma, cosmeceuticals, and others [... Read More

Molecules 2021 May 21;26(11). Epub 2021 May 21.

Faculty of Food Science and Engineering, Dunărea de Jos University of Galati, 800008 Galati, Romania.

Sea buckthorn ( L.) is recognized as a valuable source of vitamin C and antioxidants, frequently used as nutraceuticals and cosmeceuticals. In the present study, attempts are made to produce and characterize a novel type of marmalade using sea buckthorn berries processed at 102 °C into marmalade in two combinations, with whole cane or stevia sugar. Read More

Molecules 2021 May 3;26(9). Epub 2021 May 3.

Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317 Oslo, Norway.

Chitosan has many useful intrinsic properties (e.g., non-toxicity, antibacterial properties, and biodegradability) and can be processed into high-surface-area nanofiber constructs for a broad range of sustainable research and commercial applications. Read More

Foods 2021 May 2;10(5). Epub 2021 May 2.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

is reported as a source of several nutritional contents and bioactive compounds, especially β-glucan. However, various uncontrolled processes lead to the formation of byproducts that can affect human health, including biogenic amines. These amines are concerning, because their presence is an important indicator of the process of hygiene and food spoilage or quality. Read More

J Cosmet Dermatol 2021 May 22. Epub 2021 May 22.

Department of Pharmaceutics, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

Background: Antioxidants are widely used in cosmetic products as they have beneficial effects on skin and prevent skin from harmful effects of environment. Albizia lebbeck has a significant potential to be used in cosmeceuticals due to its antioxidant activity.

Objectives: The aim of this study was to formulate a stable and effective o/w emulsion-based emulgel containing Albizia lebbeck bark extract, which have considerable antioxidant activity. Read More

Front Pharmacol 2021 4;12:655771. Epub 2021 May 4.

Department of Chemistry, National Dong Hwa University, Shoufeng, Taiwan.

Skin direct contact with chemical or physical substances is predisposed to allergic contact dermatitis (ACD), producing various allergic reactions, namely rash, blister, or itchy, in the contacted skin area. ACD can be triggered by various extremely complicated adverse outcome pathways (AOPs) remains to be causal for biosafety warrant. As such, commercial products such as ointments or cosmetics can fulfill the topically safe requirements in animal and non-animal models including allergy. Read More

Crit Rev Biotechnol 2021 May 20:1-23. Epub 2021 May 20.

Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, Republic of Korea.

Algae are the oldest representatives of the plant world with reserves exceeding hundreds of millions of tons in the world's oceans. Currently, a growing interest is placed toward the use of algae as feedstocks for obtaining numerous natural products. Algae are a rich source of polyphenols that possess intriguing structural diversity. Read More

Bot Stud 2021 May 18;62(1). Epub 2021 May 18.

Department of Soil and Environmental Sciences, National Chung Hsing University, Taichung, 40227, Taiwan.

Background: The soil quality and health of the tea plantations are dependent on agriculture management practices, and long-term chemical fertilizer use is implicated in soil decline. Hence, several sustainable practices are used to improve and maintain the soil quality. Here, in this study, changes in soil properties, enzymatic activity, and dysbiosis in bacterial community composition were compared using three agricultural management practices, namely conventional (CA), sustainable (SA), and transformational agriculture (TA) in the tea plantation during 2016 and 2017 period. Read More

Chem Biodivers 2021 May 14. Epub 2021 May 14.

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Huachiew Chalermprakiet University, Samutprakarn, 10250, Thailand.

The aim of this research was to investigate and compare the antioxidant, anti-tyrosinase, anti-aging, and anti-inflammatory activities of 16 herbal extracts for topical application in cosmetic/cosmeceutical products. Herbal plant materials were extracted by infusion in boiled water for 15 min. The total phenolic content and total flavonoid content of each extract were investigated by the Folin-Ciocalteu and aluminum chloride methods, respectively. Read More

Cutis 2021 Mar;107(3S):2-8

Nanomedicine 2021 Apr 29;35:102402. Epub 2021 Apr 29.

Neofluidics LLC, San Diego, CA, USA. Electronic address:

In the last decade, microfluidics has opened new avenues for the synthesis of nanomaterials. However, the adoption of this production technique has been limited to a few high-value, low-production-volume organic nanoparticles. While there are several technical factors that can be attributed to this slow adoption, an important aspect to consider is the lack of a unified platform capable of producing a wide range of nanomaterials. Read More

J Food Sci Technol 2021 May 6;58(5):1623-1639. Epub 2020 Aug 6.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200 Thailand.

Biogenic amines (BAs) are organic nitrogenous compounds, formed mostly by decarboxylation of corresponding amino acids. BAs are responsible for several biological events. However, if the concentration of BAs reached the threshold level, it causes mild to serious health problems in human. Read More

Prev Nutr Food Sci 2021 Mar;26(1):100-108

Department of Food Science and Nutrition, Daegu Catholic University, Gyeongbuk 38430, Korea.

Five flavonol glycosides including quercetin 3--β-D-glucoside (QG), kaempferol 3--β-D-glucoside (KG), quercetin 3--(6″--acetyl)-β-D-glucoside (QAG), kaempferol 3--(6″--acetyl)-β-D-glucoside (KAG), and quercetin 3--(3″---coumaroyl)-β-D-glucoside (QCG) were isolated and purified from red pine ( Sieb. et Zucc.) nee-dles, and identified by nuclear magnetic resonance and mass spectrometer spectral analyses. Read More

J Cosmet Dermatol 2021 Apr 7. Epub 2021 Apr 7.

Department of Dermatology and Allergy, University Hospital of Munich, LMU, Munich, Germany.

Background: The treatment of facial erythema and subjective symptoms of rosacea patients remains challenging in clinical practice. Cosmeceuticals, care components containing active ingredients such as phytochemicals, play a growing role in treatment plans. However, well-designed studies on their efficacy and limitations are widely missing. Read More

JAAD Case Rep 2021 Apr 23;10:96-98. Epub 2021 Feb 23.

Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Mar Drugs 2021 Mar 22;19(3). Epub 2021 Mar 22.

Department. of Marine Science and Convergence Engineering, College of Science and Technology, Hanyang University, Gyeonggi-do 11558, Korea.

The skin health benefits of seaweeds have been known since time immemorial. They are known as potential renewable sources of bioactive metabolites that have unique structural and functional features compared to their terrestrial counterparts. In addition, to the consciousness of green, eco-friendly, and natural skincare and cosmetics products, their extracts and bioactive compounds such as fucoidan, laminarin, carrageenan, fucoxanthin, and mycosporine like amino acids (MAAs) have proven useful in the skincare and cosmetic industries. Read More

Molecules 2021 Mar 12;26(6). Epub 2021 Mar 12.

Office of Research Affairs, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Alzheimer's disease (AD) is a common neurodegenerative disorder. The number of patients with AD is projected to reach 152 million by 2050. Donepezil, rivastigmine, galantamine, and memantine are the only four drugs currently approved by the United States Food and Drug Administration for AD treatment. Read More

Molecules 2021 Mar 14;26(6). Epub 2021 Mar 14.

Department of Pharmacognosy, University of Zagreb Faculty of Pharmacy and Biochemistry, Marulićev trg 20, 10 000 Zagreb, Croatia.

is an ancient edible plant from the Fabaceae family. In this work, two eco-friendly methods for extraction of bioactive phenolics from were developed using mixtures of water with two non-toxic, skin- and environmentally-friendly polyol solvents: glycerol and polypropylene glycol. Ultrasound-assisted extractions were optimized using a Box-Behnken design. Read More

Aesthet Surg J Open Forum 2020 Dec 23;2(4):ojaa041. Epub 2020 Sep 23.

Food Sci Nutr 2021 Mar 31;9(3):1750-1760. Epub 2021 Jan 31.

Department of Pharmaceutical Sciences Faculty of Pharmacy Chiang Mai University Chiang Mai Thailand.

Lycopene is one of naturally occurring carotenoids in plants including watermelon . Heat, light, and oxygen effect on lycopene isomerization and degradation. Nanostructured lipid carriers (NLCs) are drug delivery system which can enhance the stability of active compound. Read More

Eng Life Sci 2021 Mar 18;21(3-4):68-76. Epub 2020 Dec 18.

Laboratory of Cell Biosystems The Stephan Angeloff Institute of Microbiology Bulgarian Academy of Sciences Plovdiv Bulgaria.

Plants have been used as the main source of phytochemicals with nutritional, medicinal, cultural and cosmetic applications since times immemorial. Nowadays, achieving sustainable development, global climate change, restricted access to fresh water, limited food supply and growing energy demands are among the critical global challenges faced by humanity. Plant cell culture technology has the potential to address some of these challenges by providing effective tools for sustainable supply of phyto-ingredients with reduced energy, carbon and water footprints. Read More

J Cosmet Dermatol 2021 Mar 10. Epub 2021 Mar 10.

Division of Cosmetic Science, Department of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.

Background: Skin quality plays an important role in overall attractiveness. However, so far, no visual grading scales have been published while their development seems to be an essential key step to provide validated grading scales for the evaluation of efficacy of minimally invasive procedures and cosmeceuticals aims on the improvement of skin quality, esthetic research, and clinical application.

Objectives: To develop and validate a visual five-point assessment scale for the evaluation of skin quality of female facial skin. Read More

Pharmaceutics 2021 Feb 17;13(2). Epub 2021 Feb 17.

Aquaporins Group, Centro de Edafología y Biología Aplicada del Segura (CEBAS-CSIC), Campus de Espinardo, E-30100 Murcia, Spain.

Pomegranate extract (PG-E) has been reported to exert a protective effect on the skin due to its antioxidant activity. Ingredients rich in phenolic compounds are unstable in extract solutions, and, therefore, the use of a suitable nanosystem to encapsulate this type of extract could be necessary in different biotechnological applications. Thus, we investigated the capacity of L. Read More

Molecules 2021 Feb 28;26(5). Epub 2021 Feb 28.

Food BioSciences, Teagasc, Ashtown, Dublin 15, Ireland.

Seaweeds have a long history of use as food, as flavouring agents, and find use in traditional folk medicine. Seaweed products range from food, feed, and dietary supplements to pharmaceuticals, and from bioenergy intermediates to materials. At present, 98% of the seaweed required by the seaweed industry is provided by five genera and only ten species. Read More

Int J Mol Sci 2021 Feb 28;22(5). Epub 2021 Feb 28.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Via Salvador Allende, Baronissi, 84081 Salerno, Italy.

3-hydroxytyrosol (HT) is the main phenolic compound found in olive oil with known antioxidant, anti-inflammatory, and antimicrobial properties in several dermatological conditions, both when taken in the form of olive oil or pure in cosmeceutical formulations. To date, its direct effect on the wound healing process and the molecular mechanisms involved have not yet been elucidated. Thus, in the present study, we aimed to explore its effects in vitro in epidermal keratinocyte cultures focusing on the molecular mechanism implied. Read More

Pharmaceutics 2021 Feb 25;13(3). Epub 2021 Feb 25.

Department of Nanoscience and Technology, Alagappa University, Karaikudi 630003, India.

Alzheimer's disease (AD) is a multifaceted neuronal disorder and a challenge to medical practitioners, as the blood-brain barrier (BBB) acts as a major obstacle for drug delivery to the brain. Development of a nanomaterial-based drug delivery system (DDS) paved a way to penetrate the BBB. Starch, a ubiquitous natural biopolymer, has received much attention as a DDS due to its biocompatibility, biodegradability and eco-friendly nature. Read More

Pharmacol Res 2021 Apr 1;166:105521. Epub 2021 Mar 1.

Indigenous Knowledge Systems Centre, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X2046, Mmabatho 2745, South Africa. Electronic address:

Marine habitats are well-known for their diverse life forms that are potential sources of novel bioactive compounds. Evidence from existing studies suggests that these compounds contribute significantly to the field of pharmaceuticals, nutraceuticals, and cosmeceuticals. The isolation of natural compounds from a marine environment with protease inhibitory activity has gained importance due to drug discovery potential. Read More

Crit Rev Biotechnol 2021 Jun 26;41(4):535-563. Epub 2021 Feb 26.

ERA-Chair for Food (By-) Products Valorisation Technologies (VALORTECH), Estonian University of Life Sciences, Tartu, Estonia.

Synthetic pigments from petrochemicals have been extensively used in a wide range of food products. However, these pigments have adverse effects on human health that has rendered it obligatory to the scientific community in order to explore for much safer, natural, and eco-friendly pigments. In this regard, exploiting the potential of agri-food wastes presumes importance, extracted mainly by employing green processing and extraction technologies. Read More