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Eur J Pharm Sci 2019 Feb 5;131:39-49. Epub 2019 Feb 5.

Manose Health and Beauty Research Center, Muang, Chiang Mai, 50200, Thailand; Faculty of Engineering and Technology, North-Chiang Mai University, Chiang Mai 50230, Thailand. Electronic address:

Physicochemical characteristics and in vitro anti-skin aging activity of gallic acid loaded in niosomes were investigated. Gallic acid was loaded in neutral (Brij 52/cholesterol at 7:3) and cationic CTAB niosomes (Brij 52/cholesterol/cetyltrimethylammonium bromide at 7:3:0.65). Read More

Molecules 2019 Jan 18;24(2). Epub 2019 Jan 18.

Department of Ecology, Faculty of Sciences, Campus Universitario de Teatinos s/n, Malaga University, 29071 Malaga, Spain.

This study was designed to evaluate the potential use of algal extracts in cosmeceuticals, including factors related to biosecurity. The aqueous crude extracts of and showed a good photoprotective capacity (Sun Protection Factor, SPF) due to, among other reasons, the presence of five types of mycosporine-like amino acids (MAAs) detected by high pressure liquid chromatography-photodiode array detector (HPLC-PDA) and electrospray ionization mass spectrometry (ESI-MS) (Palythine, Asterina-330, Shinorine, Porphyra-334, and Palythinol). The toxicity of the extracts was evaluated by the MTT assay, which is based on the metabolic reduction of MTT [3-(4,5-dimethylthiazol-2yl)-diphenyl tetrazolium bromide] by the action of the mitochondrial enzyme succinate dehydrogenase. Read More

Toxins (Basel) 2018 Dec 24;11(1). Epub 2018 Dec 24.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Fermented foods (FF) are widely consumed around the world, and FF are one of the prime sources of toxins and pathogenic microbes that are associated with several foodborne outbreaks. Mycotoxins (aflatoxins, fumonisins, sterigmatocystin, nivalenol, deoxynivalenol, zearalenone, ochratoxin, and alternariol), bacterial toxins (shiga toxin and botulinum), biogenic amines, and cyanogenic glycosides are the common toxins found in FF in addition to the pathogenic microbes. Fermented milk products and meat sausages are extremely vulnerable to contamination. Read More

J Immunoassay Immunochem 2019 26;40(1):91-108. Epub 2018 Dec 26.

a Department of Biochemistry, Faculty of Dentistry , Jamia Millia Islamia , New Delhi , India.

Many ingredients in cosmetic products help to develop complex formulations that improve the quality of life in terms of disease prevention, health maintenance, beauty enhancement, and building self-esteem. The beneficial effects promoted from the use of biomolecule-rich substances into the formulations of various topical application products are considered useful ingredients in cosmetic and therapeutic applications. This review article attempts to understand the various biomolecules found in cosmetic products, particularly macromolecules, which may have an important role in prevention or preservation. Read More

J AOAC Int 2018 Dec 17. Epub 2018 Dec 17.

Amity Institute for Herbal and Biotech Products Development, 3-Ravi Nagar, Peroorkada PO, Thiruvananthapuram, Kerala, India 695 005.

: Herbal formulations have reached tremendous acceptability as therapeutic agents for several diseases mainly due to the indiscriminate use of modern medicine such as antibiotics, steroids and other synthetic drugs. The increasing popularity in plant-based drugs is leading to a fast growing market for plant-based drugs pharmaceuticals, nutraceuticals, functional foods, and even cosmeceuticals. : The development of authentic analytical methods for complex herbal drugs, especially poly herbal formulations which can reliably profile the phytochemical composition, including quantitative analyses of marker/bioactive compounds and other major constituents, is a major challenge to scientists. Read More

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

In general, fermented foods (FFs) are considered as functional foods. Since the awareness about the health benefits of FFs has increased, the consumption of FF also improved significantly in recent decades. Diabetes is one of the leading threats of the health span of an individual. Read More

Food Sci Biotechnol 2018 Dec 1;27(6):1761-1769. Epub 2018 Jun 1.

1Department of Marine Life Science, Jeju National University, Jeju, 63243 Republic of Korea.

Enzyme-assisted extraction is a cost-effective, safe, and efficient method to obtain bioactives from plant materials. During this study, 10 different marine algae from Sri Lanka were individually extracted by using five commercial food-grade carbohydrases. The enzymatic and water extracts of the seaweeds were analyzed for their antioxidant and anti-inflammatory activities. Read More

Mar Drugs 2018 Nov 21;16(11). Epub 2018 Nov 21.

School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea.

Marine algae are considered to be an abundant sources of bioactive compounds with cosmeceutical potential. Recently, a great deal of interest has focused on the health-promoting effects of marine bioactive compounds. Carbohydrates are the major and abundant constituent of marine algae and have been utilized in cosmetic formulations, as moisturizing and thickening agents for example. Read More

Dermatol Clin 2019 Jan 1;37(1):107-115. Epub 2018 Nov 1.

Dermatology Consulting Services, PLLC, 2444 North Main Street, High Point, NC 27262, USA. Electronic address:

Cosmeceuticals are cosmetics that promise to deliver physiologically relevant benefits without the incorporation of prescription drugs. To entice consumers to purchase these premium priced products, a story must be told of how the cosmeceutical delivers on these appearance improvement promises. The backbone of any cosmeceutical skin care regimen is facial cleansing and moisturizing. Read More

J Cosmet Dermatol 2019 Feb 19;18(1):94-106. Epub 2018 Nov 19.

Tennessee Clinical Research Center, Nashville, Tennessee.

Background: Skincare cosmeceutical products have been shown to address intrinsic and extrinsic skin aging. Radiofrequency (RF) with microneedling is effective and safe in improving skin laxity and texture. Pairing skincare cosmeceutical products pre- and post-procedure is beneficial as it enhances patient results, patient results, patient experience, and reduces patient downtime. Read More

Oxid Med Cell Longev 2018 23;2018:5469159. Epub 2018 Sep 23.

Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Ancona, Italy.

Reactive oxygen species (ROS) production in the skin is among the highest compared to other organs, and a clear correlation exists between ROS production and skin aging. Many attempts are underway to reduce oxidative stress in the skin by topical treatment or supplementation with antioxidants/cosmeceuticals, and cultures of human dermal fibroblasts (HDF) are widely used for these studies. Here, we examined the influence of oxygen tension on cell aging in HDF and how this impacted ROS production, the enzymatic and nonenzymatic antioxidant response system, and the efficacy of this defense system in limiting DNA damage and in modulating gene expression of proteins involved in the extracellular matrix, linked to skin aging. Read More

Differentiation 2018 Nov - Dec;104:22-35. Epub 2018 Oct 16.

Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Human skin organ culture (hSOC) is a simple but highly instructive and clinically relevant skin research method. It has been used for decades to study the development, differentiation, and function as well as the response to wounding or test agents of intact human skin in the presence of its appendages and all resident cell populations. hSOC has also proven useful in toxicological and oncological studies and studies of skin aging (both chronological aging and photoaging), skin energy metabolism, skin immunology, pigmentation biology, and cutaneous (neuro-)endocrinology and neurobiology. Read More

J Biosci Bioeng 2018 Oct 30. Epub 2018 Oct 30.

Bioresource Collection and Research Center, Food Industry Research and Development Institute, HsinChu 300, Taiwan. Electronic address:

Neoagaro-oligosaccharides prepared by agar hydrolysis have various application fields, including the pharmaceutical, cosmetic, and food industries. In this study, an agarolytic strain was isolated from a saltwater hot spring and identified as Microbulbifer pacificus LD25 by 16S rRNA. The whole genome sequence of M. Read More

Mar Drugs 2018 Oct 22;16(10). Epub 2018 Oct 22.

Food Phytochemistry Department, Instituto de la Grasa (CSIC), University Campus, Building 46, Carretera de Utrera km. 1., 41013 Sevilla, Spain.

The benefit of carotenoids to human health is undeniable and consequently, their use for this purpose is growing rapidly. Additionally, the nutraceutical properties of carotenoids have attracted attention of the food industry, especially in a new market area, the 'cosmeceuticals.' Marine organisms (microalgae, seaweeds, animals, etc. Read More

J Integr Med 2018 Nov 5;16(6):427-434. Epub 2018 Oct 5.

Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand. Electronic address:

Objective: The leaves of Chromolaena odorata, a highly invasive shrub found growing wild worldwide, are traditionally used for wound healing. Due to its high flavonoid contents, we aimed to find a new application for this plant. Preliminary tests using its ethanolic leaf extract showed that it could suppress the accumulation of lipids in adipocytes. Read More

Int J Med Mushrooms 2018 ;20(8):797-808

Mushroom Biology and Fungal Biotechnology Laboratory, Department of Natural Resources and Environmental Design, College of Agriculture and Environmental Sciences, North Carolina Agricultural and Technical State University, Greensboro, North Carolina.

Agaricus bisporus, also known as the white button mushroom or champignon, is the most cultivated mushroom species worldwide. In addition to its favorable nutrient profile, it contains a number of compounds with antioxidant, antibacterial, anti-inflammatory, antitumor, and immunomodulatory activities. Waste biomass is a secondary product obtained from A. Read More

Crit Rev Ther Drug Carrier Syst 2018 ;35(5):469-494

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai, India.

The development of nanoscale particles offers tremendous potential for the formulation of nanobubbles, an area of great interest in therapeutic ultrasound, detection, diagnosis, and drug delivery systems. This review compiles information for designing nanobubbles tailored to various applications such as color Doppler imaging, multidrug-resistant treatment, cosmeceuticals, gene therapy, cancer treatment, water treatment, and so forth. Nanobubbles also extend a path for convenient and eco-friendly systems for cleaning conducting surfaces. Read More

Med Arch 2018 Apr;72(2):136-140

Biota Laboratories, R&D Center, Sancaktepe, Istanbul, Turkey.

Background: Currently while, topical minoxidil and oral finasteride are the only medications approved in androgenetic alopecia (AGA), the cause oriented treatment and immunsupressive treatment are being performed in telogen effluvium (TE) and alopecia areata (AA) respectively. Considering the inflammatory factors in the pathogenesis of these three nonscarring alopecia forms, we have formulated a mixture for topical usage composed of six different herbal extracts (HE) which have already known antiinflammatory and antioxidant features.

Materials And Methods: In addition to performing the phytochemical analysis of HE, we detected the gene expression level of IL-1α, the crucial hair loss mediator, for the putative efficacy in nonscarring alopecia. Read More

Mar Drugs 2018 Sep 14;16(9). Epub 2018 Sep 14.

Department of Biology and Evolution of Marine Organisms (BEOM), Stazione Zoologica Anton Dohrn (SZN), 80121 Villa Comunale, Napoli, Italy.

Solar radiation represents a key abiotic factor in the evolution of life in the oceans. In general, marine, biota-particularly in euphotic and dysphotic zones-depends directly or indirectly on light, but ultraviolet radiation (UV-R) can damage vital molecular machineries. UV-R induces the formation of reactive oxygen species (ROS) and impairs intracellular structures and enzymatic reactions. Read More

J Photochem Photobiol B 2018 Nov 1;188:50-59. Epub 2018 Sep 1.

Nano Safety and Risk Assessment Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, Thailand. Electronic address:

Bombyx mori silk extracts, derived from the cocoon degumming process of draw and dye silk in the textile industry, are mainly composed of sericin protein. To add value to the Thai silk extracts, and hence the silk industry, a simple enrichment process was recently developed and the enriched silk extracts were then applied in nano-cosmeceutical products and nano-delivery systems. In this study, the protective effect of Thai silk extracts from three different strains of Bombyx mori on the drug-induced phototoxicity was evaluated in vitro using chlorpromazine (CPZ), a commonly used antipsychotic drug, as a representative phototoxic drug. Read More

Facial Plast Surg Clin North Am 2018 Nov 16;26(4):407-413. Epub 2018 Aug 16.

Division of Cosmetic Dermatology, University of Miami, 4500 Biscayne Boulevard Suite 101, Miami, FL 33137, USA. Electronic address:

Skin aging is caused by DNA damage in nuclei and mitochondria, inflammation, glycation, decreased function of keratinocytes and fibroblasts and breakdown of heparan sulfate, hyaluronic acid, collagen, and elastin. Identifying patients at an increased risk of skin aging using a standardized methodology to diagnose the Baumann Skin Type will allow doctors to prescribe an efficacious antiaging skin care regimen. Cosmeceuticals can activate LGR6+ stem cells, improve cell response to signals such as growth factors, stimulate collagen genes, neutralize free radicals, and decrease breakdown of collagen and elastin. Read More

Sci Pharm 2018 Sep 11;86(3). Epub 2018 Sep 11.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Fermented foods are known for several health benefits, and they are generally used among the Asian people. Microorganisms involved in the fermentation process are most responsible for the final quality of the food. Traditional fermented (spontaneous fermentation) foods are a versatile source of bioactive molecules and bioactive microbes. Read More

Crit Rev Biotechnol 2018 Sep 9:1-15. Epub 2018 Sep 9.

a Department of Marine Life Science , Jeju National University , Jeju , Republic of Korea.

The cosmetics industry is one of the most profitable in the world today. This multi-billion-dollar industry has a profound sociological impact worldwide. Its influence is global, with most individuals being concerned with conserving their physical appearance, beauty, and youth. Read More

Expert Opin Drug Deliv 2018 Oct 10;15(10):927-935. Epub 2018 Sep 10.

a Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries , Future University in Egypt , Cairo , Egypt.

Background: The present work aims to formulate nanostructured lipid carriers (NLCs) exhibiting high skin deposition and high inherent antioxidant potential to repurpose the use of melatonin hormone and some antioxidant oils in the treatment of androgenic alopecia (AGA).

Research Design And Methods: NLCs were characterized for their size, charge, drug entrapment, anti-oxidant potential, physical stability, in vitro release, surface morphology, and ex-vivo skin deposition. Their merits were clinically tested on patients suffering from AGA by calculating the degree of improvement, conduction of hair pull test, histometric assessment, and dermoscopic evaluation. Read More

Oxid Med Cell Longev 2018 7;2018:7858094. Epub 2018 Aug 7.

Application Technique Engineering Center of Natural Cosmeceuticals, College of Fuijan Province, Xiamen Medical College, Fujian, Xiamen 361023, China.

A polyphenol-enriched fraction (PEF) from , whose leaves have been traditionally utilized for the treatment of diverse medical ailments, was investigated for the anti-inflammatory effect and molecular mechanisms by using lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophages and acetaminophen- (APAP-) induced liver injury mouse model. Results showed that PEF significantly attenuated LPS-induced nitric oxide (NO) and prostaglandin E (PGE) production and suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in RAW 264. Read More

Int J Biol Macromol 2018 Dec 19;120(Pt A):255-262. Epub 2018 Aug 19.

Silkworm Physiology Laboratory, Central Tasar Research and Training Institute (Central Silk Board), P.O. Piska-Nagri, Ranchi 835303, Jharkhand, India.

Tropical tasar silkworm Antheraea mylitta is a wild sericigenous insect which is distributed in different geographical regions and named as different ecoraces. In the present study, we investigated the molecular characterisation and cosmeceutical properties of sericin extracted from different ecoraces of tasar cocoons. The surface morphology and molecular weight of cocoons were determined by scanning electron microscope (SEM) and SDS-PAGE, respectively. Read More

J Cosmet Dermatol 2018 Oct 21;17(5):693-702. Epub 2018 Aug 21.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Skin health is an important aspect of aesthetics. Dermatologists and scientists try to develop novel methods and materials to fulfill this aim. Facial cosmetics keep skin moist and remove sebum from the skin to maintain proper skin health. Read More

J Biosci Bioeng 2019 Jan 8;127(1):59-65. Epub 2018 Aug 8.

Department of Biological Science and Technology, China University of Science and Technology, No. 245, Sec. 3, Academia Rd., Nangang Dist., Taipei City 11581, Taiwan. Electronic address:

Asparagus cochinchinensis root (ACR) is used in traditional Chinese medicine. In this study, ACR was first extracted with 25% ethyl acetate (EA) and then fermented by Aspergillus oryzae to enhance its antioxidant activity and evaluate its potential antityrosinase activity. The physiological activity and cytotoxicity of A. Read More

AMB Express 2018 Jul 16;8(1):115. Epub 2018 Jul 16.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.

Rice husk (RH) is the major agricultural waste obtained during rice hulling process, which can be a sustainable source of xylooligosaccharide (XOS). The current study deals with the production of XOS from Thai rice husk using alkaline pretreatment and enzyme hydrolysis method. The response surface methodology consisted of central composite design and Box-Behnken design was employed to achieve the maximum response in alkaline pretreatment and XOS production, respectively. Read More

J Cosmet Dermatol 2019 Feb 19;18(1):251-257. Epub 2018 Jun 19.

Cure Bio Co., Ltd. Research Center, Suwon-si, Korea.

Background: Human skin aging is caused by several factors, such as UV irradiation, stress, hormone, and pollution. Wrinkle formation and skin pigmentation are representative features of skin aging. Although EGF and arbutin are used as anti-wrinkle and skin whitening agents, respectively, they have adverse effects on skin. Read More

Clin Dermatol 2018 May - Jun;36(3):289-298. Epub 2018 Mar 10.

Private practice, Fruitland, ID. Electronic address:

Mucocutaneous diseases and conditions, including aging, are known to be the result of multiple pathophysiologic anomalies induced by various environmental insults. Creating therapeutic products for these multifactorial diseases and conditions is challenging. Although safety testing is not required for cosmetics and cosmeceuticals, consumer expectation is for products to be effective and well tolerated while maintaining cosmetic elegance. Read More

Anaerobe 2018 Aug 17;52:64-74. Epub 2018 May 17.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Propionibacterium acnes has been recognized as a main target for medical treatment of acne since this bacterium promotes acne inflammation by inducing upregulation of pro-inflammatory cytokines production, resulting in an accumulation of neutrophils and oxygen-free radicals produced by neutrophils within acne lesion. The aims of this study were to evaluate the biological activities of Mangifera indica kernel extracts grown in Northern Thailand (Kaew-Moragot cultivar), related to anti-acne properties including antimicrobial effect against acne-inducing bacteria together with the first elucidation of the mechanism of action against Propionibacterium acnes, anti-oxidation, and anti-inflammation. The kernels of M. Read More

Lipids Health Dis 2018 Jun 15;17(1):138. Epub 2018 Jun 15.

Laboratory of Forestry Resources Management and Valorization, National Research Institute of Rural Engineering, Water and Forests, P.B. 10, 2080, Ariana, Tunisia.

Background: Argan oil is traditionally produced by cold pressing in South-western Morocco where rural population uses it as edible oil as well as for its therapeutic properties which give them in counterpart valuable income. Given the economical interest of this oil, several attempts of fraudulency have been registered in the world global market leading to loss of authenticity. Our purpose is to launch a program of Tunisian Argan oil valorization since trees from this species have been introduced sixty years ago in Tunisia. Read More

J Food Sci Technol 2018 Jun 3;55(6):2310-2317. Epub 2018 May 3.

5Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Milkfish (), which is resistant to water quality changes is the fourth largest aquaculture commodity. Abandoned wastes of fish scale and bones aggravate environmental pollution. In this study, the effect of collagen peptides isolated from milkfish scales (MSCP) by pepsin-soluble collagen method on cell viability was investigated. Read More

Antioxidants (Basel) 2018 May 23;7(6). Epub 2018 May 23.

Department of Experimental Medicine, Section of Biotechnology Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", via L. De Crecchio No. 7, 80138 Napoli, Italy.

Olive oil boasts numerous health benefits due to the high content of the monounsaturated fatty acid (MUFA) and functional bioactives including tocopherols, carotenoids, phospholipids, and polyphenolics with multiple biological activities. Polyphenolic components present antioxidant properties by scavenging free radicals and eliminating metabolic byproducts of metabolism. The objective of this research project was to recover the biologically active components rich in polyphenols, which include treatment of olive oil mills wastewater, and, at the same time, to remove the pollutant waste component resulting from the olive oil manufacturing processes. Read More

Sci Pharm 2018 May 31;86(2). Epub 2018 May 31.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Food is an essential need for all living creatures which provides the energy to maintain life and grow further. Fermentation is a process used to preserve and advance the quality of foods, and those foods are known as fermented foods. Some foods offer health benefits to consumers apart from nutrition, and such foods are called as functional foods. Read More

Phytother Res 2018 Sep 22;32(9):1688-1706. Epub 2018 May 22.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Thymol is a naturally occurring phenol monoterpene derivative of cymene and isomer of carvacrol. Thymol (10-64%) is one of the major constituent of essential oils of thyme (Thymus vulgaris L., Lamiaceae), a medicinal plant with several therapeutic properties. Read More

J Pharm (Cairo) 2018 27;2018:3420204. Epub 2018 Mar 27.

Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh 201301, India.

Nanotechnology manifests the progression in the arena of research and development, by increasing the efficacy of the product through delivery of innovative solutions. To overcome certain drawbacks associated with the traditional products, application of nanotechnology is escalating in the area of cosmeceuticals. Cosmeceuticals are regarded as the fastest growing segment of the personal care industry and the use has risen drastically over the years. Read More

Int J Med Mushrooms 2018 ;20(2):141-153

Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; Mushroom Research Centre, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.

Five culinary-medicinal mushrooms are commonly available in the Malaysian market: Agaricus bisporus (white and brown), Ganoderma lucidum, Hypsizygus marmoreus, Pleurotus floridanus, and P. pulmonarius. These species were selected for use in the current study, the aim of which was to investigate the antimelanogenesis and anti-inflammatory activity of these mushrooms in an attempt to evaluate their potential use in cosmeceuticals. Read More

Molecules 2018 May 9;23(5). Epub 2018 May 9.

Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 020956 Bucharest, Romania.

Liquid marbles are versatile structures demonstrating a pseudo-Leidenfrost wetting regime formed by encapsulating microscale volumes of liquid in a particle shell. The liquid core is completely separated from the exterior through air pockets. The external phase consists of hydrophobic particles, in most cases, or hydrophilic ones distributed as aggregates. Read More

J Evid Based Integr Med 2018 Jan-Dec;23:2515690X18765699

4 Health Innovation Institute, Chiang Mai, Thailand.

The current study investigated the antidiabetic property of Lactobacillus fermentum HP3-mediated fermented Hericium erinaceus juice (FHJ) using male Wistar rats with streptozotocin-induced diabetes mellitus (DM). FHJ was prepared using boiled mushroom juice and L. fermentum HP3. Read More

Nutrients 2018 Apr 4;10(4). Epub 2018 Apr 4.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Colorectal cancer occurs due to various factors. The important risks are dietary lifestyle and inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. It has been found that the inhibitory enzyme cyclooxygenase-2 (COX-2) in the colorectal region can potentially reduce the risk of colorectal cancer. Read More

Surg Technol Int 2018 06;32:33-45

Generational and Cosmetic Dermatology, Rancho Mirage, CA.

Carboxytherapy is the therapeutic use of carbon dioxide (CO2) in its gaseous state. Since 1933, carboxytherapy has referred to either the subcutaneous injection of CO2 or percutaneous application in a warm bath. The present clinical study was performed to determine if there were any changes in the dermis after the application of a transcutaneous gel, which is claimed to produce CO2, and, if so, how these changes compared to those with CO2 injection. Read More

Nutr Res 2018 04 11;52:87-97. Epub 2018 Feb 11.

Department of Biological Science and Technology, China University of Science and Technology, Taipei, Taiwan; Research Center of Natural Cosmeceuticals Engineering, Xiamen Medical College, Xiamen, Fujian, China. Electronic address:

Arctigenin (ATG), a lignin extracted from Arctium lappa (L.), exerts antioxidant and anti-inflammatory effects. We hypothesized that ATG exerts a protective effect on hepatocytes by preventing nonalcoholic fatty liver disease (NAFLD) progression associated with lipid oxidation-associated lipotoxicity and inflammation. Read More

Planta Med 2018 Sep 5;84(14):988-1006. Epub 2018 Mar 5.

School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, Thailand.

Skin hyperpigmentation is caused by several factors that upregulate melanogenesis. Plants and natural products with skin-whitening effects are gaining interest among consumers and researchers because they are perceived to be milder, safer, and healthier than synthetic alternatives. This review extensively summarizes the status of plants and natural products currently used in skin-whitening cosmetics as well as potential candidates for future use, because the scope of natural choices for efficient treatment of skin hyperpigmentation is rapidly widening. Read More

J Cosmet Laser Ther 2018 Nov - Dec;20(7-8):470-481. Epub 2018 Feb 20.

a Laser Research Centre, Faculty of Health Sciences , University of Johannesburg , Doornfontein , South Africa.

A blemish free, even-toned skin is universally associated with healthy skin. This reasoning makes people desire to have a flawless skin. Melanin is a naturally occurring pigment in humans. Read More

Curr Drug Deliv 2018 ;15(7):953-964

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Antioxidants are among the most important cosmeceuticals, with proven ability of inhibiting cellular damage. The topical skin administration of antioxidants is essential for minimizing skin aging and achieving better skin protection against harmful free radicals. However, their unfavorable physiochemical properties such as chemical instability, excessive hydrophilicity or lipophilicity and others could be a great obstacle against their skin promising effects as well as their delivery to deeper skin layers. Read More

Int J Dermatol 2018 Jun 12;57(6):646-660. Epub 2018 Feb 12.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

Skin is the largest and easily accessible organ of the body. Increases in incidences of dermatological disorders, demand for drug targeting, and patient compliance have increased the popularity of topical drug delivery amongst the people. However, drug delivery across the skin is still a challenge for researchers because permeation of maximum drugs is hindered by the upper layer of the epidermis (stratum corneum). Read More

J Microbiol Biotechnol 2018 Apr;28(4):527-533

Department of Bio and Fermentation Convergence Technology, BK21 PLUS project, Kookmin University, Seoul 02707, Republic of Korea.

This study compared the radioprotective effects of high-molecular-weight poly-gamma-glutamate (γ-PGA, average molecular mass 3,000 kDa) and a reduced form of glutathione (GSH, a known radioprotector) on calf thymus DNA damage. The radiation-induced DNA damage was measured on the basis of the decreased fluorescence intensity after binding the DNA with ethidium bromide. All the experiments used ⁶⁰Co gamma radiation at 1,252 Gy, representing 50% DNA damage. Read More

J Cosmet Dermatol 2018 Jun 24;17(3):305-312. Epub 2018 Jan 24.

Marmur Medical, New York, NY, USA.

Background: The cosmeceutical industry is an ever-growing and in demand market, especially in Asia. Korea has been on the forefront of creating the newest generation and most innovative cosmeceuticals products including ingredients such as snail secretions, starfish powder, botanical extracts, green tea, and red ginseng. Given their increasing prevalence in the cosmeceutical industry, scientists have been conducting investigations into these extracts and their properties. Read More