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    262 results match your criteria Cosmeceuticals

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    Evaluation of Therapeutic Laser Influences on the Healing of Third-degree Burns in Rats According to Different Wavelengths.
    J Cosmet Laser Ther 2017 Feb 6. Epub 2017 Feb 6.
    d Private Practice , Tehran , Iran ( the Islamic Republic of ).
    Introduction: One of the most important innovative methods for tissue repair promotion is therapeutic lasers with photobiomodulution effects. The aim of this study was to investigate the effect of four different wavelengths of therapeutic laser (405 nm, 532 nm, 660 nm and 810 nm) laser on healing of third-degree burn injuries from both clinical and pathological standpoint of view in rats.

    Material And Methods: 60 male Wistar rats were used. Read More

    Effects of Laser-Assisted Lipolysis on Nipple-Areola Complex.
    J Cosmet Laser Ther 2017 Feb 2. Epub 2017 Feb 2.
    b Department of Plastic, Reconstructive and Aesthetic Surgery , Bezmialem Medical School, Bezmialem Vakif University , Istanbul - TURKEY.
    Background: Gynecomastia, as a most common benign condition represents itself as the enlargement of the male breast and also nipple-areola complex as the severity of the condition increases. With this study, we aimed to clarify the effects of 980-nm diode laser on nipple-areolar complex (NAC).

    Objectives: Although numerous open techniques have been described to correct gynecomastia, nowadays trends have shifted to minimally invasive techniques such as laser-assisted lipolysis (LAL). Read More

    The Use of Cosmeceuticals in Acne: Help or Hoax?
    Am J Clin Dermatol 2017 Jan 6. Epub 2017 Jan 6.
    Department of Dermatology, Penn State/Hershey Medical Center, HU14, 500 University Drive, Hershey, PA, 17022, USA.
    The use of cosmeceuticals by patients with acne is common; however, their role is unclear and confusing, with many asking, "Do they really help acne?" Cosmeceuticals are intermediate products between prescription medications and cosmetics, available to consumers over the counter. These products are popular and may be used without the direct supervision of a dermatologist, creating a practice gap in educating patients. Herein, a variety of cosmeceuticals are discussed, including retinoids, niacinamide, and glycolic acid. Read More

    Development and efficacy assessments of tea seed oil makeup remover.
    Ann Pharm Fr 2016 Dec 14. Epub 2016 Dec 14.
    School of Cosmetic Science, Mae Fah Luang University, 333, Tasud Muang, 57100 Chiang Rai, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, 333, Tasud Muang, 57100 Chiang Rai, Thailand. Electronic address:
    Introduction: The efficacy of tea seed oil to clean foundation and eyeliner was evaluated. The safe and efficient tea seed oil makeup remover was developed.

    Materials And Methods: In vitro cleansing efficacy of makeup remover was UV-spectrophotometric validated. Read More

    Skin Care for Women.
    Nurs Womens Health 2017 Dec 2016 - Jan;20(6):609-613
    Women are inundated with advertisements for products promising younger-looking, healthier skin. The truth is that many of these products can be expensive and produce results that do not live up to the claims. Health care providers can educate women about proven best practices and how to evaluate products' claims of benefits. Read More

    Cosmeceuticals in skin of color.
    Semin Cutan Med Surg 2016 Dec;35(4):233-237
    Baumann Cosmetic and Research Institute, Miami, Florida, USA.
    Patients with skin of color have similar skin care needs as lighter-skin patients. However, they are less likely to use sun protection on a daily basis, which leads to an increased risk of dyschromia, skin cancer, and other disorders. This article discusses the importance of a correct and consistent skin care regimen and the various cutaneous issues that should be considered when prescribing a skin care regimen for patients with darker skin types. Read More

    A review on synthesis, properties and applications of natural polymer based carrageenan blends and composites.
    Int J Biol Macromol 2017 Mar 30;96:282-301. Epub 2016 Nov 30.
    Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan.
    Carrageenan is a natural polysaccharide extracted from edible red seaweeds of Rhodophycea class. It has been used as a viscosity increasing or gelling agent for prolonged and controlled drug release, food, pharmaceuticals and other industries. However, in spite of wide range of applications, carrageenan has some drawbacks and adverse effects on the biological systems, so its modifications with natural and synthetic polymers are carried out. Read More

    Anti-aging and tyrosinase inhibition effects of Cassia fistula flower butanolic extract.
    BMC Complement Altern Med 2016 Dec 3;16(1):497. Epub 2016 Dec 3.
    Department of Obstetrics & Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
    Background: Natural products made from plant sources have been used in a variety of cosmetic applications as a source of nutrition and as a whitening agent. The flowers of Cassia fistula L, family Fabaceae, have been used as a traditional medicine for skin diseases and wound healing and have been reported to possess anti-oxidant properties. The anti-aging effect of C. Read More

    Curative effects of microneedle fractional radiofrequency system on skin laxity in Asian patients: A prospective, double-blind, randomized, controlled face-split study.
    J Cosmet Laser Ther 2017 Feb 1:1-6. Epub 2017 Feb 1.
    c University Hospital of Basel , Switzerland.
    Background: To date, no studies compared curative effects of thermal lesions in deep and superficial dermal layers in the same patient (face-split study).

    Objective: To evaluate skin laxity effects of microneedle fractional radiofrequency induced thermal lesions in different dermal layers.

    Methods And Materials: 13 patients underwent three sessions of a randomized face-split microneedle fractional radiofrequency system (MFRS) treatment of deep dermal and superficial dermal layer. Read More

    Patents on Therapeutic and Cosmetic Applications of Bioactives of Crocus Sativus L. and their Production through Synthetic Biology Methods: A Review.
    Recent Pat Biotechnol 2016 Nov 14. Epub 2016 Nov 14.
    CSIR- Unit for Research and Development of Information Products, (CSIR-URDIP), Pune, Maharashtra, India.
    Background: Saffron (Crocus sativus L.) has a long history of use as a food additive and a traditional medicine for treating a number of disorders. Prominent bioactives of saffron are crocin, crocetin and safranal. Read More

    Filler migration to the forehead due to multiple filler injections in a patient addicted to cosmetic fillers.
    J Cosmet Laser Ther 2017 Jan 25:1-3. Epub 2017 Jan 25.
    a Department of Dermatology , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.
    Filler migration is a potential complication following the injection of multiple fillers. With the increasing popularity of multiple filler injections, migrated granulomas should be an essential differential diagnosis for newly growing facial lumps. It is important for all physicians to be aware that complication induced by dermal fillers can occur in locations other than the planned injected sites. Read More

    A review on laser and light-based therapies for alopecia areata.
    J Cosmet Laser Ther 2017 Jan 25:1-7. Epub 2017 Jan 25.
    a University of Miami Miller School of Medicine , Dermatology and Cutaneous Surgery , Miami, United States.
    Alopecia areata is a form of non-scarring alopecia that results from a hyperactive immune response of T cells against hair follicles. Many patients with visible hair loss experience psychological and emotional distress, as a result of their cosmetic disfigurement, and frequently seek treatment. However, existing treatment methods, such as corticosteroids, topical irritants, sensitizing agents, immunosuppressants, and psoralen plus ultraviolet light A, may result in various adverse effects and often lack efficacy. Read More

    Blends and composites of exopolysaccharides; properties and applications: A review.
    Int J Biol Macromol 2017 Jan 3;94(Pt A):10-27. Epub 2016 Oct 3.
    Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan. Electronic address:
    Exopolysaccharides are synthesized by bacteria and secreted into the external environment and they may be homopolymeric or heteropolymeric in configuration. They are believed to protect bacterial cells from heavy metals, desiccation or other environmental effect. EPS exhibit antitumor, anti-HIV, emulsion stabilization capacity, shear-thinning activity, suspension ability, high viscosities, excellent biocompatibility, high biodegradability and immunomodulatory properties. Read More

    Extracellular Metabolites from Industrial Microalgae and Their Biotechnological Potential.
    Mar Drugs 2016 Oct 20;14(10). Epub 2016 Oct 20.
    School of Food Science and Engineering, South China University of Technology, Wushan Rd. 381, Guangzhou 510641, China.
    Industrial microalgae, as a big family of promising producers of renewable biomass feedstock, have been commercially exploited for functional food, living feed and feed additives, high-value chemicals in nutraceuticals, cosmeceuticals, and chemical reagents. Recently, microalgae have also been considered as a group that might play an important role in biofuel development and environmental protection. Almost all current products of industrial microalgae are derived from their biomass; however, large amounts of spent cell-free media are available from mass cultivation that is mostly unexploited. Read More

    Polydeoxyribonucleotide improves wound healing of fractional laser resurfacing in rat model.
    J Cosmet Laser Ther 2017 Feb 2;19(1):43-48. Epub 2016 Dec 2.
    b Department of Dermatology , Seoul St. Mary's Hospital , Seoul , Republic of Korea.
    Background: Polydeoxyribonucleotide (PDRN) is an active compound that can promote wound healing. PDRN stimulates wound healing by enhancing angiogenesis and increasing fibroblast growth rates. Laser skin resurfacing is a popular cosmetic procedure for skin rejuvenation. Read More

    Jasmine rice panicle: A safe and efficient natural ingredient for skin aging treatments.
    J Ethnopharmacol 2016 Dec 6;193:607-616. Epub 2016 Oct 6.
    School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100 Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai 57100, Thailand.
    Ethnopharmacological Relevance: While rice is one of the most important global staple food sources its extracts have found many uses as the bases of herbal remedies. Rice extracts contain high levels of phenolic compounds which are known to be bioactive, some of which show cutaneous benefits and activity towards skin disorders. This study highlights an assessment of the cellular activity and clinical efficacy of rice panicle extract, providing necessary information relevant to the development of new cosmetic products. Read More

    Utility of Ochrobactrum anthropi YC152 in a Microbial Fuel Cell as an Early Warning Device for Hexavalent Chromium Determination.
    Sensors (Basel) 2016 Aug 16;16(8). Epub 2016 Aug 16.
    Department of Biological Science and Technology, China University of Science and Technology, Taipei 11581, Taiwan.
    Fast hexavalent chromium (Cr(VI)) determination is important for environmental risk and health-related considerations. We used a microbial fuel cell-based biosensor inoculated with a facultatively anaerobic, Cr(VI)-reducing, and exoelectrogenic Ochrobactrum anthropi YC152 to determine the Cr(VI) concentration in water. The results indicated that O. Read More

    Micro-Needling Depth Penetration, Presence of Pigment Particles, and Fluorescein-Stained Platelets: Clinical Usage for Aesthetic Concerns.
    Aesthet Surg J 2017 Jan 16;37(1):71-83. Epub 2016 Aug 16.
    Dr Sasaki is a Clinical Professor, Loma Linda Medical University Center, Loma Linda, CA
    Background: Aesthetic micro-needling (MN) has demonstrated skin permeability to cosmeceutical ingredients and platelet-rich plasma by creating reversible micro-channels in the skin.

    Objectives: The purposes of this study were to determine: (1) actual needle depth-penetrations by adjusting needle lengths in a disposable tip of an electric MN device; (2) time-dependent passage of pigment and platelets; and (3) safety and efficacy profiles in patients.

    Methods: Excised micro-needled pre-auricular skin was used to determine actual depths of tissue penetration with six needle lengths, and the presence of massaged pigment particles (histological examination) and fluorescein-labeled platelets (confocal laser microscopy) in 1 mm depth micro-channels over an hour. Read More

    Skin aging and oxidative stress: Equol's anti-aging effects via biochemical and molecular mechanisms.
    Ageing Res Rev 2016 Nov 9;31:36-54. Epub 2016 Aug 9.
    Department of Physiology and Developmental Biology and The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA. Electronic address:
    Oxygen in biology is essential for life. It comes at a cost during normal cellular function, where reactive oxygen species (ROS) are generated by oxidative metabolism. Human skin exposed to solar ultra-violet radiation (UVR) dramatically increases ROS production/oxidative stress. Read More

    Fifty years of research and development of cosmeceuticals: a contemporary review.
    J Cosmet Dermatol 2016 Dec 6;15(4):527-539. Epub 2016 Aug 6.
    Department of Dermatology, Frimley Park Hospital NHS Foundation Trust, Frimley, UK.
    Facial rejuvenation can be categorized into skincare and facial contouring. Research and development of cosmeceuticals is aimed at addressing the major signs of photoaging: wrinkles, dyschromia, and sallowness. Assessment of photoaging comes in clinical and photographic forms; a photonumeric scale developed by Griffiths et al. Read More

    Topical peptides as cosmeceuticals.
    Indian J Dermatol Venereol Leprol 2017 Jan-Feb;83(1):9-18
    Department of Dermatology, Goa Medical College, Bambolim, Goa, India.
    Peptides are known to have diverse biological roles, most prominently as signaling/regulatory molecules in a broad variety of physiological processes including defense, immunity, stress, growth, homeostasis and reproduction. These aspects have been used in the field of dermatology and cosmetology to produce short, stable and synthetic peptides for extracellular matrix synthesis, pigmentation, innate immunity and inflammation. The evolution of peptides over the century, which started with the discovery of penicillin, has now extended to their usage as cosmeceuticals in recent years. Read More

    (4R,6S)-2-Dihydromenisdaurilide is a Butenolide that Efficiently Inhibits Hepatitis C Virus Entry.
    Sci Rep 2016 Jul 18;6:29969. Epub 2016 Jul 18.
    Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
    Without a vaccine, hepatitis C virus (HCV) remains a significant threat, putting 170-300 million carriers worldwide at risk of cirrhosis and hepatocellular carcinoma. Although the direct-acting antivirals targeting HCV replication have revolutionized the treatment of hepatitis C, several obstacles persist, including resistance development, potential side-effects, and the prohibitive cost that limits their availability. Furthermore, treatment of HCV re-infection in liver transplantation remains a significant challenge. Read More

    Meeting the Challenges of Acne Treatment in Asian Patients: A Review of the Role of Dermocosmetics as Adjunctive Therapy.
    J Cutan Aesthet Surg 2016 Apr-Jun;9(2):85-92
    Dr SN Wong Skin, Hair, Nails and Laser Specialist Clinic, Mt Elizabeth Medical Centre, Singapore.
    Conventional acne treatment presents several challenges such as intolerable side effects and antibiotic resistance. Dermocosmetic products may be used to reduce these unwanted effects. Dermocosmetics include skin cleansers, topical sebum-controllers, skin antimicrobial/anti-inflammatory agents, moisturizers, sunscreens, and camouflage products. Read More

    Infraorbital Dark Circles: A Review of the Pathogenesis, Evaluation and Treatment.
    J Cutan Aesthet Surg 2016 Apr-Jun;9(2):65-72
    TOC Eye and Face, Austin, USA.
    Infraorbital dark circles represent a common and multifactorial challenge in the world of aesthetic medicine and are the result of a variety of factors including deep facial anatomy, soft tissue changes, as well as contributions from the skin. A variety of treatment options exist, and a customised management strategy can be developed for the particular anatomic changes present. A literature search using MEDLINE and non-MEDLINE sources was performed utilising keywords including: 'Dark circles' 'infraorbital dark circles', 'infraorbital pigment', 'under-eye circles' and 'lower eyelid bags'. Read More

    Topical Products for the Aging Face.
    Clin Plast Surg 2016 Jul 11;43(3):597-604. Epub 2016 May 11.
    Discovery Partners, LLC, 4913 Southern Hills Drive, Frisco, TX 75034, USA. Electronic address:
    This article focuses on nonprescription home-use topical treatment technologies for the aging face and is intended to serve as a guide for the core cosmeceutical technologies currently used and to help educate and assist the selection of topical antiaging products by the professional staff and their patients. Antiaging topical treatments for patient home use should be nonirritating, compatible with the patient skin type, effective, and complementary to surgical and minimally invasive office procedures, and aesthetically elegant. New topical antiaging technologies, formulated as monotherapy or as combinations with well-known cosmeceuticals, should present adequate clinical studies to support their selection for use. Read More

    Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds: A review.
    J Photochem Photobiol B 2016 Sep 16;162:100-5. Epub 2016 Jun 16.
    Laboratory of Marine Bioresource Technology, Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, Jeju 690-756, Republic of Korea. Electronic address:
    Currently, natural ingredients are becoming more attractive for the industries such as functional food, nutraceuticals, cosmeceutical and pharmaceutical industries as people starting to believe naturally occurring compounds are safer to humans than artificial compounds. Seaweeds are one of the most interesting organisms found in oceans around the earth, which are carrying great ecological importance and contribute to increase the biodiversity of ecosystems where they were originated and habitat. Within last few decades, discovery of secondary metabolites with biological activities from seaweeds has been significantly increased. Read More

    Etiology and Management of Allergic Eyelid Dermatitis.
    Ophthal Plast Reconstr Surg 2016 Jun 20. Epub 2016 Jun 20.
    Department of Ophthalmology and Visual Sciences, Washington University in St. Louis. St. Louis, Missouri, U.S.A.
    Purpose: Allergic dermatitis is a common but often misdiagnosed condition that can present with a variety of findings including inflammation, eyelid malposition, and tearing. This study was performed to identify likely etiologies, along with presenting findings and treatment strategies for allergic dermatitis.

    Methods: A retrospective review of clinical records was performed of patients diagnosed with allergic dermatitis in academic oculoplastics practices from 2002 to 2014. Read More

    Current Perspective in the International Trade of Medicinal Plants Material: An Update.
    Curr Pharm Des 2016 ;22(27):4288-336
    University Institute of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.
    Background: The recent years have seen an increased interest in medicinal plants together with the therapeutic use of phytochemicals. Medicinal plants are utilized by the industry for the production of extracts, phytopharmaceuticals, nutraceuticals and cosmeceuticals and their use is expected to grow faster than the conventional drugs. The enormous demand of medicinal plant material has resulted in huge trade both at domestic and international levels. Read More

    Enzymatic synthesis of bioactive compounds with high potential for cosmeceutical application.
    Appl Microbiol Biotechnol 2016 Aug 8;100(15):6519-43. Epub 2016 Jun 8.
    Department of Chemical Sciences, University of Naples "Federico II", Naples, Italy.
    Cosmeceuticals are cosmetic products containing biologically active ingredients purporting to offer a pharmaceutical therapeutic benefit. The active ingredients can be extracted and purified from natural sources (botanicals, herbal extracts, or animals) but can also be obtained biotechnologically by fermentation and cell cultures or by enzymatic synthesis and modification of natural compounds. A cosmeceutical ingredient should possess an attractive property such as anti-oxidant, anti-inflammatory, skin whitening, anti-aging, anti-wrinkling, or photoprotective activity, among others. Read More

    Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy.
    Int J Nanomedicine 2016 11;11:1987-2007. Epub 2016 May 11.
    Department of Applied Life Science, Nanotechnology Research Center, Chungju, Republic of Korea; Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea.
    Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Read More

    Melasma and Post Inflammatory Hyperpigmentation: Management Update and Expert Opinion.
    Skin Therapy Lett 2016 Jan;21(1):1-7
    Spalding Drive Plastic Surgery and Cosmetic Dermatology, Beverly Hills, CA, USA.
    Dyschromia is a leading cause for cosmetic consultation, especially in those with diverse skin types (mixture of ethnicities) and with the rise of non-core and untrained physicians performing cosmetic procedures. Melasma and post-inflammatory hyperpigmentation (PIH) account for the majority of cases and are characterized by pigmented macules and patches distributed symmetrically in sun-exposed areas of the forehead, cheeks, and chin in melasma, and irregularly in areas of inflammation or an inciting traumatic event with PIH. Treatment is challenging and focused on a variety of mechanisms to stop, hinder, and/or prevent steps in the pigment production (melanocytic hyperactivity) process, breaking down deposited pigment for internal removal or external release, exfoliating cells to enhance turnover, and decreasing inflammation. Read More

    Laser-Assisted Drug Delivery.
    Dermatol Surg 2016 Aug;42(8):919-31
    *Department of Dermatology, Naval Medical Center San Diego, San Diego, California; †Cosmetic Laser Dermatology, San Diego, California.
    Background: Laser-assisted drug delivery (LADD) is an evolving new therapy with many possible applications as a highly targeted customizable method for distribution of drugs within the skin. LADD offers the advantages of accessibility, noninvasiveness, compliance, safety, and effectiveness.

    Objective: To review the available literature regarding LADD. Read More

    Super-cooled and amorphous lipid-based colloidal dispersions for the delivery of phytosterols.
    Soft Matter 2016 Jul;12(27):5835-46
    Unilever R&D Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands. and Soft Condensed Matter, Debye Institute for Nanomaterials Science, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands.
    Super-cooled and amorphous lipid-based colloids are highly desirable delivery systems because of their ability to encapsulate compounds in a soluble or in a non-crystalline state. In this study, we demonstrate the preparation and characterization of super-cooled and amorphous lipid-based nanoscale colloidal dispersions containing high concentrations of phytosterols (PSs). PSs are highly hydrophobic natural bioactive compounds that are known to significantly reduce blood cholesterol levels in humans, but are insoluble in water and are poorly soluble in common lipids such as triacylglycerols (TAGs). Read More

    Cosmeceuticals: peptides, proteins, and growth factors.
    J Cosmet Dermatol 2016 Dec 3;15(4):514-519. Epub 2016 May 3.
    Faculty of Health Sciences, University of Granada, Granada, Spain.
    Recent research advances in the molecular and biochemical processes involved in wound healing and skin aging have led to the development of innovative cosmeceuticals that rely on peptides, proteins, and growth factors to enhance skin health. Although the long-term benefits of these products have not been fully tested and evaluated, evidence of the benefits derived from their use is steadily growing. This study describes the peptides, proteins, and growth factors that are most frequently used in cosmeceuticals and discusses their potential benefits and practical use in dermatology. Read More

    Polysaccharides from the Marine Environment with Pharmacological, Cosmeceutical and Nutraceutical Potential.
    Molecules 2016 Apr 27;21(5). Epub 2016 Apr 27.
    Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy.
    Carbohydrates, also called saccharides, are molecules composed of carbon, hydrogen, and oxygen. They are the most abundant biomolecules and essential components of many natural products and have attracted the attention of researchers because of their numerous human health benefits. Among carbohydrates the polysaccharides represent some of the most abundant bioactive substances in marine organisms. Read More

    Usefulness of liquid-crystal oral formulations to enhance the bioavailability and skin tissue targeting of p-amino benzoic acid as a model compound.
    Eur J Pharm Sci 2016 Jun 9;88:282-90. Epub 2016 Apr 9.
    Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. Electronic address:
    Topical formulations are not always suitable to deliver active ingredients to large areas of skin. Thus, in this study, we aimed to develop an oral formulation for skin tissue targeting with a high bioavailability using liquid crystal (LC) dispersions comprising cubosomes of a mal-absorptive model compound, p-amino benzoic acid (PABA), which is an active element in cosmeceuticals, dietary supplements and skin disorder medicines. The bioavailability and skin concentration of PABA were investigated after oral administration in rats. Read More

    An Approach to Cosmeceuticals.
    J Drugs Dermatol 2016 Apr;15(4):452-6
    The cosmeceutical industry is a multi-billion dollar, consumer-driven market. Products promise highly desirable anti-aging benefits, but are not subject to regulation. We present an introduction to cosmeceuticals for the general and cosmetic dermatologist, including definitions and explanations of key terms, an approach to the evidence base, a dissection of chamomile and green tea, two paradigmatic cosmeceutical products, and a window into the underlying psychology of this vast marketplace. Read More

    Skin whitening capability of shikimic acid pathway compound.
    Eur Rev Med Pharmacol Sci 2016 ;20(6):1214-20
    Department of Pharmacy and Research Center of Natural Cosmeceuticals Engineering (RCNCE), Xiamen Medical College, Xiamen, China.
    Objective: To examine the skin whitening capabilities of shikimic acid pathway compounds and find the most effective molecule to be used as the active ingredient for skin whitening products.

    Materials And Methods: Skin whitening is the practice of using chemical substances to lighten skin tone by the lessening the concentration of melanin. The whitening efficacy of shikimic acid pathway compounds was evaluated. Read More

    In vitro models to estimate drug penetration through the compromised stratum corneum barrier.
    Drug Dev Ind Pharm 2016 Nov 13;42(11):1742-51. Epub 2016 Apr 13.
    a Department of Pharmacy, Drug Transport and Delivery Research Group , University of Tromsø The Arctic University of Norway , Tromsø , N-9037 , Norway.
    Objectives: The phospholipid vesicle-based permeation assay (PVPA) is a recently established in vitro stratum corneum model to estimate the permeability of intact and healthy skin. The aim here was to further evolve this model to mimic the stratum corneum in a compromised skin barrier by reducing the barrier functions in a controlled manner.

    Methods: To mimic compromised skin barriers, PVPA barriers were prepared with explicitly defined reduced barrier function and compared with literature data from both human and animal skin with compromised barrier properties. Read More

    Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry.
    Antiviral Res 2016 Jun 21;130:58-68. Epub 2016 Mar 21.
    Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Without a vaccine, hepatitis C virus (HCV) remains a global medical and socio-economic burden, predisposing about 170 million carriers worldwide to end-stage liver diseases including cirrhosis and hepatocellular carcinoma. Although the recently developed direct-acting antivirals (DAAs) have revolutionized hepatitis C treatment, most of them are unsuitable for monotherapy due to risks of resistance, thus necessitating combination with interferon (IFN)-alpha, ribavirin, or additional DAAs. More importantly, the high cost associated with the DAAs restricts their accessibility to most parts of the world. Read More

    Prospects and challenges for industrial production of seaweed bioactives.
    J Phycol 2015 Oct 22;51(5):821-37. Epub 2015 Sep 22.
    Acadian Seaplants Limited, 30 Brown Avenue, Cornwallis, Nova Scotia, Canada.
    Large-scale seaweed cultivation has been instrumental in globalizing the seaweed industry since the 1950s. The domestication of seaweed cultivars (begun in the 1940s) ended the reliance on natural cycles of raw material availability for some species, with efforts driven by consumer demands that far exceeded the available supplies. Currently, seaweed cultivation is unrivaled in mariculture with 94% of annual seaweed biomass utilized globally being derived from cultivated sources. Read More

    Biopolymeric agents for skin wrinkle treatment.
    J Cosmet Laser Ther 2016 Oct 22;18(5):301-10. Epub 2016 Apr 22.
    a School of Cosmetic Science , Mae Fah Luang University, Chiang Rai, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University , Chiang Rai , Thailand.
    Skin aging is caused by several factors capable of deteriorating dermal matrix and is visibly noticed in skin color and skin contour deformities. In addition to the prevention of skin aging by application of antioxidants and sunscreens, treatment of skin wrinkles with those of dermal fillers is also recommended. Dermal filler products with enhanced injectability and longer duration are being developed continuously. Read More

    Superior Efficacy of an Herbal-based Cosmeceutical Compared With Common Prescription and Cosmetic Antiaging Therapies.
    J Drugs Dermatol 2016 Feb;15(2):218-23
    Introduction: Research has shown that a disrupted stratum corneum permeability barrier coupled with chronic inflammation induce signs of extrinsic aging (photoaging). An novel herbal-based three product cosmeceutical regimen used to reverse these two anomalies that does not contain retinol, soy, niacinamide, tea, L-ascorbic acid or esters, hydroxy acids, tocopherol, or growth factors was tested in six human clinical trials to determine effectiveness and safety in reversing photoaging.

    Materials And Methods: Six randomized split face, double blind, prospective, controlled clinical trials involving a total of 110 subjects compared a cosmeceutical blend of novel herbs in regimens consisting of one to three products to several common antiaging topical treatments. Read More

    Clinical Assessment of a Novel Jasmonate Cosmeceutical, LR2412-Cx, for the Treatment of Skin Aging.
    J Drugs Dermatol 2016 Feb;15(2):209-15
    Background: The jasmonates are a novel class of plant-derived anti-aging compounds. Among these, LR2412-Cx (tetrahydrojasmonic acid, Visionnaire) has been demonstrated to reduce photoaging and the appearance of wrinkles, as well as to upregulate collagens, hyaluronic acid and fibrillin.

    Objective: To clinically study the cosmetic effects of a novel jasmonate complex LR2412-Cx in the treatment of visible skin aging. Read More

    Development of cetyl dimethicone based water-in-oil emulsion containing botanicals: Physical characteristics and stability.
    Pak J Pharm Sci 2016 Jan;29(1):173-8
    Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islaima University of Bahawalpur, Pakistan.
    The aim of current research was to develop a water-in-oil emulsion containing grape seed extract for application in cosmeceuticals. Finally grinded dried grape seeds powder was extracted with hydro alcoholic mixture. Emulsions consisting of different concentrations of cetyl dimethicone (Abile EM90), the nonionic emulsifier, liquid paraffin as oily phase and water as aqueous phase were developed. Read More

    Natural Cosmeceutical Ingredients for Hyperpigmentation.
    J Drugs Dermatol 2016 Jan;15(1):26-34
    As Dermatologists caring for patients with hyperpigmentation problems, we are always looking for more alternative therapies. Hydroquinone (HQ) is still the standard of care. However, traditional depigmenting agents such as HQ and corticosteroids, although highly effective, can raise safety concerns including exogenous ochronosis, atrophy, carcinogenesis and local and systemic untoward effects with long term use. Read More

    Enhanced efficacy of a topical antioxidants regimen in conjunction with a home-use non-ablative fractional diode laser in photodamaged facial skin.
    J Cosmet Laser Ther 2016 Jun 31;18(3):154-61. Epub 2016 Mar 31.
    b L'Oreal Research & Innovation , Clark , NJ , USA ;
    Background: Photodamaged facial skin is characterized by fine lines and wrinkles, mottled pigmentation, and other changes.

    Objective: To evaluate and compare the efficacy and tolerance of a home-use laser device when used alone or in combination with an antioxidant facial treatment for moderate photodamage.

    Methods: This was a 49-subject, evaluator-blinded, split-face, randomized, single-center, 24-week, phase-2, study. Read More

    Analysis of bacterial diversity and efficiency of continuous removal of Victoria Blue R from wastewater by using packed-bed bioreactor.
    Chemosphere 2016 Feb 1;145:17-24. Epub 2015 Dec 1.
    Department of Biological Science and Technology, China University of Science and Technology, Taipei, 115, Taiwan. Electronic address:
    The characteristics of a packed-bed bioreactor (PBB) for continuously removing Victoria Blue R (VBR) from an aqueous solution were determined. The effects of various factors including liquid retention time (RT), VBR concentration, shock loading, and coexisting compounds on the VBR removal and bacterial community in a continuous system were investigated. The intermediates of degraded VBR and the acute toxicity of the effluent from PBB were analyzed. Read More

    Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin.
    Phytother Res 2015 Dec 13;29(12):1917-25. Epub 2015 Oct 13.
    Faculty of Biotechnology, College of Applied Life Sciences, SARI, Jeju National University, Jeju, Republic of Korea.
    Camphor ((1R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one), a bicyclic monoterpene, is one of the major constituents of essential oils from various herbs such as rosemary, lavender, and sage. Read More

    Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.
    Oxid Med Cell Longev 2015 10;2015:709628. Epub 2015 Sep 10.
    Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
    The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Read More

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