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Bone Joint J 2020 Jul;102-B(7_Supple_B):52-56

Colorado Joint Replacement, Denver, Colorado, USA.

Aims: Of growing concern in arthroplasty is the emergence of atypical infections, particularly (formerly ) sp. infections. Currently, the dermal colonization rate of about the hip is unknown. Read More

Eye Contact Lens 2020 Jul;46(4):e27-e29

Ögonkliniken (I.F., A.B.), Västerviks Sjukhus, Västervik, Sweden; and Ögonkliniken (P.G.-H.), Vrinnevisjukhuset, Norrköping, Sweden.

Keratitis due to Candida parapsilosis or Corynebacterium macginleyi is uncommon. We present a patient with several risk factors who suffered two subsequent corneal infections caused by these pathogens and healed with topical conservative therapy. The important factor was the early detection of infection. Read More

Animals (Basel) 2020 Jun 18;10(6). Epub 2020 Jun 18.

Department of Bioprocess Engineering, Microbiology, Faculty 2, University of Applied Sciences and Arts, 30453 Hannover, Germany.

To reduce the negative effects of mastitis in dairy heifers in early lactation on the future milking performance, the aim of this study was to define the time-related period of intramammary infections and to relate this to risk factors at heifer and quarter level for intramammary infections and subclinical mastitis. In total, 279 German Holstein Frisian heifers in three farms in Northern and Eastern Germany were included in this study. Quarter milk samples for cytomicrobiological examination were collected 3 ± 1 days after calving and 17 ± 3 days after calving, and risk factors at heifer and quarter level associated with intramammary infections and clinical mastitis were recorded during the trial period. Read More

Antonie Van Leeuwenhoek 2020 Aug 4;113(8):1225-1239. Epub 2020 Jun 4.

Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case of necrotizing lymphadenitis in a wild boar. Read More

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620930930

University of Szeged, Szeged, Hungary.

Septic cerebral emboli can be a challenging diagnosis to give, especially if atypical bacterial infections are the cause of it. Correct diagnosis of this condition can change the management route of the patient and result in a nonsurgical treatment. To our best knowledge, this is the first case of septic cerebral embolus caused by reported. Read More

BMC Infect Dis 2020 Jun 1;20(1):389. Epub 2020 Jun 1.

Department of Neurology, The General Hospital of Western Theater Command, No.270 Rongdu Avenue, Jinniu District, Chengdu, 610083, Sichuan Province, People's Republic of China.

Background: Intracranial infections with Corynebacterium striatum (C. striatum) have been described sporadically in the literature over the last two decades. However, C. Read More

J Med Virol 2020 May 30. Epub 2020 May 30.

Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium parvum (Cutibacterium acnes). This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activity, but the interest to successfully prevent and treat bacterial, fungal, and viral infections and lethality, uprising the innate immunity barriers produced many experimental models and very few clinical studies. The dramatic defenseless situation due to impending CoViD-19 pandemic claims to exhume and highlight this aspecific strategy in preventive and therapeutic settings; as a matter of fact, no new or mutated virus can potentially escape to this strong innate immune surveillance strengthened by adequate C. Read More

Eye Contact Lens 2020 Jul;46(4):254-261

Manchester Royal Eye Hospital (A.O., A.W., A.B., F.C.), Manchester University NHS Foundation Trust, Manchester, United Kingdom; and Division of Pharmacy & Optometry (V.R., A.J.M., H.R.), School of Health Sciences, Faculty of Biology, Medicine and Health, the University of Manchester, Manchester, United Kingdom.

Objectives: To assess publications examining the occurrence, composition, and clinical significance of a microbiome at the ocular surface.

Methods: MEDLINE, EMBASE, and Google Scholar were searched. Reference lists of included articles were also searched for relevant citations. Read More

Microb Drug Resist 2020 May 19. Epub 2020 May 19.

Laboratory of Diphtheria and Corynebacteria of Clinical Relevance (LDCIC), Faculdade de Ciências Médicas (FCM), Universidade do Estado do Rio de Janeiro (UERJ), The Collaborating Centre for Reference and Research on Diphtheria/National Health Foundation/Ministry of Health-FNS/MS, Rio de Janeiro, Brazil.

Disinfection and antisepsis are of primary importance in controlling nosocomial infections and outbreaks by pathogens expressing multiple resistance to antimicrobial agents (multidrug-resistant [MDR]) used in therapy. Nowadays, infections related to health services (HAIs) due to MDR and multidrug-susceptible (MDS) should not be underestimated, including patients using invasive medical devices. The virulence potential of needs further investigation. Read More

Transl Androl Urol 2020 Apr;9(2):398-404

Department of Urology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Although empirical antibacterial treatments are currently recommended for inflammatory chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), physicians cannot verify infections in most cases. Therefore, in this study, the microbiota of semen was investigated via pyrosequencing to obtain evidence underlying infectious disease.

Methods: Patients diagnosed with CP/CPPS (n=17) and healthy volunteers (n=4) participated in the study. Read More

Microorganisms 2020 May 13;8(5). Epub 2020 May 13.

Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán, Argentina.

We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the and species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and infections. We demonstrated that nasally administered 090104 or 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. Read More

Perit Dial Int 2020 May 13:896860820923461. Epub 2020 May 13.

Infectious Diseases Unit, Shaare Zedek Medical Center, Affiliated with the Hebrew University, Jerusalem, Israel.

Objectives: Nontuberculous mycobacteria (NTM) infections pose a diagnostic challenge in peritoneal dialysis (PD) patients. In this study, we sought to identify findings that are suggestive of NTM infection in PD adult patients.

Methods: All patients with NTM exit-site infection (ESI) with/without tunnel infection and peritonitis identified during the last decade in eight medical centers in Israel were included. Read More

J Microbiol Methods 2020 Jun 5;173:105937. Epub 2020 May 5.

Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA. Electronic address:

Soft surfaces, including textiles are found throughout healthcare settings. Pathogens can survive for long periods of time on textiles, and can be transferred to and from the skin. Antimicrobial fabrics are used as an engineering control to prevent infection. Read More

J Med Microbiol 2020 May 5;69(5):721-727. Epub 2020 May 5.

College of the Sciences and Mathematics, West Chester University, West Chester, PA, USA.

Human skin microbial communities represent a tremendous source of genetic diversity that evolves as a function of human age. Microbiota differs between regions of oily and moist skin, and appears to stabilize with age. We have a minimal understanding of the time frame required for the stabilization of skin microbiota, and the role played by gender. Read More

Arthroplast Today 2020 Jun 23;6(2):163-168. Epub 2020 Apr 23.

Department of Orthopaedic Surgery, Duke University, Durham, NC, USA.

Prosthetic joint infections (PJIs) are typically caused by and coagulase-negative species. species are microorganisms of the human skin and mucous membranes that are often considered contaminants when grown in culture. In the past, species were often classified as diphtheroids based on growing as gram-positive rods in aerobic environments, but with advances in technology, the identification of species has improved. Read More

BMC Infect Dis 2020 Apr 25;20(1):308. Epub 2020 Apr 25.

Department of Sera and Vaccines Evaluation, National Institute of Public Health - National Institute of Hygiene, Chocimska 24, 00-791, Warsaw, Poland.

Background: Diphtheria outbreaks occurred in endemic areas and imported and indigenous cases are reported in UE/EEA. Because of the high infectiveness and severity of the disease, early and accurate diagnosis of each suspected case is essential for the treatment and management of the case and close contacts. The aim of the study was to establish simple and rapid testing methods based on Loop-Mediated Isothermal Amplification (LAMP) assay for the detection of Corynebacterium diphtheriae and differentiation between toxigenic and non-toxigenic strains. Read More

BMC Microbiol 2020 Apr 6;20(1):78. Epub 2020 Apr 6.

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Background: To date, the microbiota of the human penis has been studied mostly in connection with circumcision, HIV risk and female partner bacterial vaginosis (BV). These studies have shown that male circumcision reduces penile anaerobic bacteria, that greater abundance of penile anaerobic bacteria is correlated with increased cytokine levels and greater risk of HIV infection, and that the penile microbiota is an important harbour for BV-associated bacteria. While circumcision has been shown to significantly reduce the risk of acquiring human papillomavirus (HPV) infection, the relationship of the penile microbiota with HPV is still unknown. Read More

Healthcare (Basel) 2020 Mar 30;8(2). Epub 2020 Mar 30.

School of Health Sciences, The University of Newcastle, Callaghan 2308, Australia.

Healthcare-associated infections (HAIs) pose a significant occupational risk to medical radiation science (MRS) professionals, who have a high degree of patient contact. Current research largely focusses on HAIs in patients, with limited attention given to infectious organisms that MRS professionals are exposed to. This is a significant gap that this systematic review seeks to address by summarizing current literature to determine the infectious organisms within MRS departments, their reservoirs, and transmission modes. Read More

Microorganisms 2020 Mar 25;8(4). Epub 2020 Mar 25.

Department of Medicine and Health Sciences "Vincenzo Tiberio", Università degli Studi del Molise-III Ed Polifunzionale, 86100 Campobasso, Italy.

is a well-known opportunistic uropathogen that can occur with cystitis, pyelonephritis, and urinary sepsis. Although a wide variety of coryneform bacteria have been found from the male genital tract of prostatitis patients, only one clinical case of prostatitis caused by has been reported. The aim of this study was to evaluate the tropism of towards LNCaP (lymph node carcinoma of the prostate) human cells line and the influence of acetohydroxamic acid as an irreversible urease inhibitor on different aspects of its pathogenicity by means of several tests, such as the determination and analysis of growth curves, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the production of biofilms, and adhesion to LNCaP and HeLa cell lines. Read More

Euro Surveill 2020 Mar;25(11)

Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, United Kingdom.

BackgroundDiphtheria is a potentially fatal disease caused by toxigenic strains of or AimOur objective was to review the epidemiology of diphtheria in the United Kingdom (UK) and the impact of recent changes in public health management and surveillance.MethodsPutative human toxigenic diphtheria isolates in the UK are sent for species confirmation and toxigenicity testing to the National Reference Laboratory. Clinical, epidemiological and microbiological information for toxigenic cases between 2009 and 2017 are described in this population-based prospective surveillance study. Read More

Urologiia 2020 Mar(1):12-18

Rostov State Medical University, Rostov-on-Don, Russia.

Aim: To determine the frequency of occurrence of oportunistic pathogenic bacterial flora and viral pathogens in the urine of healthy people with the establishment of the association between them.

Materials And Methods: 40 healthy sexually active women and men were examined, which are divided by gender into equivalent groups: Group I - healthy women (n=19), Group II - healthy men (n=21). The age of the subjects ranged from 20 to 25 years, the average age was 22. Read More

Infection 2020 Jun 17;48(3):413-420. Epub 2020 Mar 17.

Service d'Anesthésie-Réanimation Chirurgicale, DMU CARE, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, CHU Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France.

Purpose: Corynebacterium spp. (C. spp. Read More

Respir Investig 2020 May 14;58(3):131-133. Epub 2020 Mar 14.

Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan.

Recent advances using molecular methods, matrix-assisted laser desorption ionization time of flightmass spectrometry, and next-generation sequencers enable rapid and precise detection of bacterial species in the clinical samples, revealing bacterial diversities in the human body. Corynebacterium species are Gram-positive bacilli, which can cause pneumonia and have been reported as causative pathogens of lower respiratory tract infections since the 1970's. However, Corynebacterium spp. Read More

J Diabetes Complications 2020 Jun 3;34(6):107561. Epub 2020 Mar 3.

Loyola University Chicago, Health Sciences Campus, Maywood, IL, United States of America.

Purpose: The urinary microbiota in women with type 2 diabetes (T2DM) can have bacterial uropathogens which are more virulent. The primary objective was to describe and compare the characteristics of the microbiota in voided urine of women with and without T2DM.

Methods: Two cohorts of women: those with T2DM (n = 87) and those without T2DM (n = 49) were studied. Read More

Emerg Microbes Infect 2020 17;9(1):605-615. Epub 2020 Mar 17.

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

The source of secondary lower respiratory tract bacterial infections in influenza patients is not fully understood. A case-control study was conducted during the 2017-2018 influenza epidemic period in Beijing, China. Nasopharyngeal swabs were collected from 52 virologically confirmed influenza patients and 24 healthy medical staff. Read More

Adv Exp Med Biol 2020 ;1271:21-28

Department of Pediatrics, Center of Postgraduate Medical Education, Warsaw, Poland.

The frequency of bacteremia in children hospitalized due to respiratory syncytial virus infection (RSV) rarely exceeds 1%, but a recent study reported a 10% risk of bacteremia. In this study, we set out to verify the frequency, usefulness, and costs of blood cultures in RSV infections. We addressed the issue by reviewing medical files of 512 children, aged 8 days-121 months, who were hospitalized during January 2010 and June 2017. Read More

JCI Insight 2020 Mar 12;5(5). Epub 2020 Mar 12.

Institute for Data Science and Genomic Technology, Department of Genetics and Genomic Sciences.

Relatively little is known about interactions between the airway microbiome and airway host transcriptome in asthma. Since asthma affects and is affected by the entire airway, studying the upper (e.g. Read More

Klin Lab Diagn 2020 ;65(1):42-49

Tver State Medical University, 170100, Tver, Russia.

The microflora of 64 biopsies taken during fibrogastroduodenoscopy of the mucous membrane of the esophagus, stomach and duodenum in healthy volunteers and 1120 samples obtained from the same parts of the digestive tract in patients with esophagitis, chronic gastritis and peptic ulcer disease were studied. The patients ranged in age from 18 to 62 years. Traditional bacteriological method was used to isolate and identify microorganisms. Read More

IDCases 2020 22;20:e00728. Epub 2020 Feb 22.

Department of Microbiology, Yashoda Hospitals, Secunderabad, India.

Gram positive rods seen on Gram's stain are often dismissed as skin commensal organisms. Diphtheroids (Non-diphtherial species), as they are collectively called, are taken as harmless bystanders in a skin and soft tissue infection (SSTI). However, emerging evidence has established virulence factors in some of these species leading to various infections. Read More

Res Microbiol 2020 Apr - Jun;171(3-4):122-127. Epub 2020 Feb 28.

Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France; National Reference Center for the Corynebacteria of the diphtheriae complex, Paris, France. Electronic address:

A group of six clinical isolates previously identified as Corynebacterium diphtheriae biovar Belfanti, isolated from human cutaneous or peritoneum infections and from one dog, were characterized by genomic sequencing, biochemical analysis and MALDI-TOF mass spectrometry. The six isolates were negative for the diphtheria toxin gene. Phylogenetic analyses showed that the six isolates (including FRC0190) are clearly demarcated from C. Read More

Ann Biol Clin (Paris) 2020 Feb;78(1):74-78

Laboratoire central de biologie, EPH de Rouïba, Alger, Algérie, Faculté de médecine, Université d'Alger I, Alger, Algérie.

Nosocomial infections remain a serious public health problem with serious consequences. Hospital hygiene surveys are a basic tool in the surveillance and control of nosocomial infections. These surveys are also a tool for raising the awareness and information of the nursing staff. Read More

Pathogens 2020 Feb 19;9(2). Epub 2020 Feb 19.

Department of Medical Microbiology, Faculty of Medicine, Inonu University,44280 Malatya, Turkey.

Although is part of the human flora, it has recently drawn attention both for its multidrug resistance and its role as an invasive infection/outbreak agent. This cross-sectional study aimed to determine the antimicrobial resistance and clonal relationships among strains. In total, 81 strains were identified using Phoenix-100 (BD, Sparks, MD, USA). Read More

Infect Disord Drug Targets 2020 Feb 23. Epub 2020 Feb 23.

Department of Microbiology, Government Medical College and Hospital, Sector-32, Chandigarh. India.

Corynebacterium striatum is an emerging nosocomial pathogen capable of causing a variety of infections in immunocompromised and hospitalized patients. We describe three cases of infection by C. striatum that were initially considered as contamination. Read More

Medicine (Baltimore) 2020 Jan;99(3):e18761

Department of Orthopedic Surgery.

Introduction: Corynebacterium striatum is common contaminant in clinical specimens. Here, we report a rare case of pyogenic tenosynovitis of the wrist caused by C striatum in a dermatomyositis patient taking oral immunosuppressants.

Patient Concerns: A 67-year-old Japanese woman with dermatomyositis had a history of multiple intraarticular injections of corticosteroids to the right wrist joint for the treatment of osteoarthritis. Read More

Urologiia 2019 12(6):31-37

State Research Center Institute of immunology of Federal Medical Biological Agency, Moscow, Russia.

Objective: to conduct a comparative study of the composition of the microbiota of the urethra in men with sexually transmitted infections (STIs), and healthy men.

Material And Methods: The study included 103 men aged 18 to 45 years: 42 men with urethritis caused by STIs and 61 clinically healthy men. Identification of pathogenic and conditionally pathogenic microorganisms in scrapings from the urethra was performed by PCR in real time (test system Androflor (DNA-Technology, Moscow). Read More

J Vet Med Sci 2020 Mar 29;82(3):325-332. Epub 2020 Jan 29.

General Research Service Center, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan.

Among domestic animals, melioidosis is one of the most common diseases reported in goat, sheep, and swine. To evaluate the specific antibodies in goats with melioidosis, we developed a serology test using recombinant outer membrane protein A (OmpA) and flagellin (FliC) of Burkholderia pseudomallei as antigens. DNA corresponding to each antigen was cloned into a pET32a vector and expressed in Escherichia coli. Read More

J Clin Microbiol 2020 Mar 25;58(4). Epub 2020 Mar 25.

Medical University of South Carolina, Charleston, South Carolina, USA.

Rapid identification from positive blood cultures is standard of care (SOC) in many clinical microbiology laboratories. The GenMark Dx ePlex Blood Culture Identification Gram-Positive (BCID-GP) Panel is a multiplex nucleic acid amplification assay based on competitive DNA hybridization and electrochemical detection using eSensor technology. This multicenter study compared the investigational-use-only (IUO) BCID-GP Panel to other methods of identification of 20 Gram-positive bacteria, four antimicrobial resistance genes, and both Pan and Pan Gram-Negative targets that are unique to the BCID-GP Panel. Read More

Biomed Res Int 2019 31;2019:5302307. Epub 2019 Dec 31.

Department of Nursing, College of Health Sciences, Wollo University, Amhara, Ethiopia.

Background: Each year, immunization averts an estimated 2-3 million deaths from diphtheria, tetanus, pertussis, and measles. In 2011, nearly 107 million infants (83%) worldwide received at least 3 doses of DTP vaccine; however, approximately 22.4 million failed to receive 3 doses, and this causes large numbers of children susceptible to vaccine-preventable diseases and death. Read More

Eur J Clin Microbiol Infect Dis 2020 Jun 21;39(6):1063-1070. Epub 2020 Jan 21.

Department of Diagnostics, Bacteriology Laboratory, Division of Laboratory Medicine, Geneva University Hospitals, 4 rue Gabrielle-Perret-Gentil, 1205, Geneva, Switzerland.

The objectives of this study were to define the shortest incubation times on the WASPLab for reliable MALDI-TOF/MS-based species identification and for the preparation of a 0.5 McFarland suspension for antimicrobial disk diffusion susceptibility testing using short subcultures growing on solid culture media inoculated by positive blood cultures spiked with a wide range of pathogens associated with bloodstream infections. The 520 clinical strains (20 × 26 different species) included in this study were obtained from a collection of non-consecutive and non-duplicate pathogens identified at Geneva University Hospitals. Read More

Antibiotics (Basel) 2020 Jan 16;9(1). Epub 2020 Jan 16.

"Cantacuzino" National Medico Military Institute for Research and Development, 050096 Bucharest, Romania.

Antimicrobial resistance is one of the most important public health issues. Besides classical multidrug resistance species associated with medical care involved in superficial or invasive infections, there are strains less commonly associated with hospital or outpatient setting's infections. Non-diphtheria spp. Read More

Sci Rep 2020 01 17;10(1):571. Epub 2020 Jan 17.

Technische Universität Braunschweig, Institute for Biochemistry, Biotechnology and Bioinformatics, Department of Biotechnology, Braunschweig, Germany.

Diphtheria is an infectious disease caused by Corynebacterium diphtheriae. The bacterium primarily infects the throat and upper airways and the produced diphtheria toxin (DT), which binds to the elongation factor 2 and blocks protein synthesis, can spread through the bloodstream and affect organs, such as the heart and kidneys. For more than 125 years, the therapy against diphtheria has been based on polyclonal horse sera directed against DT (diphtheria antitoxin; DAT). Read More

CMAJ 2020 01;192(2):E41

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy Medical Science & Peking Union Medical College, Beijing, China

Braz J Infect Dis 2020 Jan - Feb;24(1):89-91. Epub 2020 Jan 9.

Department of Infectious, Parasitic and Tropic Diseases of the Hospital Na Bulovce and Second Faculty of Medicine, Charles University in Prague, Czech Republic.

Clin Infect Dis 2020 Jan 10. Epub 2020 Jan 10.

Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Recent research suggests that the microbiota affects susceptibility to both respiratory (RTI) and gastrointestinal (GII) infections. Past work has mainly focused on westernised populations and the gut microbiota. In order to optimise global treatment options, it is important to characterise microbiota profiles across different niches and geographic/socioeconomic areas where RTI and GII prevalences are high. Read More

Ig Sanita Pubbl 2019 Jul-Aug;75(4):317-325

Dipartimento di Biomedicina e Prevenzione, Tor Vergata Università degli Studi di Roma, Italia.

The possible risk of hyperimmunization after tetanus vaccination is currently discussed after the National Vaccine Prevention Plan 2017-2019 confirmed the recommendation of a booster dose every ten years. Due to the ubiquitous nature of tetanus spores and the inability to obtain herd-immunity through vaccination, efforts to reduce the incidence of tetanus aim at eliminating the disease. The only way to prevent infection is vaccination followed by recommended periodic booster doses. Read More

Pol J Microbiol 2019 Dec 31;68(4):457-464. Epub 2019 Oct 31.

Department of Human Immunology, Faculty of Medicine, University of Rzeszów , Rzeszów , Poland.

Unravelling of the interplay between the immune system and non-diphtheria corynebacteria would contribute to understanding their increasing role as medically important microorganisms. We aimed at the analysis of pro- (TNF, IL-1β, IL-6, IL-8, and IL-12p70) and anti-inflammatory (IL-10) cytokines produced by Jurkat T cells in response to planktonic and biofilm Two reference strains: ATCC 700207 (R-CA), ATCC 25923 (R-SA), and ten clinical strains of (C-CA) were used in the study. Jurkat T cells were stimulated by the planktonic-conditioned medium (PCM) and biofilm-conditioned medium (BCM) derived from the relevant cultures of the strains tested. Read More

Lancet Infect Dis 2019 02 30;19(2):139. Epub 2019 Jan 30.

J Dairy Sci 2020 Feb 19;103(2):1776-1784. Epub 2019 Dec 19.

Lactodiagnostico Sur SRL, Olivos 1636, Buenos Aires, Argentina. Electronic address:

The aim of this study was to demonstrate the noninferiority of a novel teat disinfectant based on copper and zinc (ZkinCu; Copper Andino, Santiago de Chile, Chile) compared with a previously proven glycolic acid active disinfectant (OceanBlu; DeLaval, Kansas City, MO) as a positive control, with respect to the incidence of new intramammary infections under natural challenge conditions on a commercial robotic dairy farm. This study was conducted in 6 robotic pens of approximately 60 milking cows each. The pens were randomly assigned to 1 of the 2 studied disinfectants. Read More

Open Access Maced J Med Sci 2019 Sep 31;7(18):2988-2990. Epub 2019 May 31.

Department of Dermatology, University of Rome "G. Marconi", Rome, Italy.

Background: Eccrine poroma is a benign tumour of eccrine duct epithelium. The usual clinical presentation is nodular.

Case Report: We present a 78-year-old man with a painful pendulating flesh-coloured malodorous plantar tumour. Read More

PLoS One 2019 12;14(12):e0225545. Epub 2019 Dec 12.

KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.

Background: Although the significance of the human vaginal microbiome for health and disease is increasingly acknowledged, there is paucity of data on the differences in the composition of the vaginal microbiome upon infection with different sexually transmitted pathogens.

Method: The composition of the vaginal bacterial community of women with Trichomonas vaginalis (TV, N = 18) was compared to that of women with Chlamydia trachomatis (CT, N = 14), and to that of controls (N = 21) (women negative for TV, CT and bacterial vaginosis). The vaginal bacterial composition was determined using high throughput sequencing with the Ion 16S metagenomics kit of the variable regions 2, 4 and 8 of the bacterial 16S ribosomal RNA gene from the vaginal swab DNA extract of the women. Read More