Search Our Scientific Publications & Authors

Front Cell Infect Microbiol 2022 9;12:860408. Epub 2022 Jun 9.

Dept. of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States.

The discovery of the urinary microbiome (urobiome) has created opportunities for urinary health researchers who study a wide variety of human health conditions. This manuscript describes an analysis of catheterized urine samples obtained from 1,004 urobiome study participants with the goal of identifying the most abundant and/or prevalent (common) taxa in five clinically relevant cohorts: unaffected adult women (n=346, 34.6%), urgency urinary incontinence (UUI) (n=255, 25. Read More

Klin Lab Diagn 2022 Jun;67(6):350-354

G.N. Gabrichevsky Research Institute of Epidemiology and Microbiology.

The results of evaluating the effectiveness of the use of liquid transport media at the preanalytical stage of bacteriological diagnosis of diphtheria infection are presented. A typical toxigenic strain of C. diphtheriae biovar gravis № 665 was used. Read More

Viruses 2022 May 27;14(6). Epub 2022 May 27.

Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.

Globally, most Human Immunodeficiency Virus type 1 (HIV) transmission occurs through vaginal-penile sex (heterosexual transmission). The local immune environment at the site of HIV exposure is an important determinant of whether exposure during sex will lead to productive infection, and the vaginal and penile immune milieus are each critically shaped by the local microbiome. However, there are key differences in the microbial drivers of inflammation and immune quiescence at these tissue sites. Read More

Pathogens 2022 Jun 14;11(6). Epub 2022 Jun 14.

Albert Szent-Györgyi Health Center, Department of Medical Microbiology, Faculty of Medicine, University of Szeged, H-6725 Szeged, Hungary.

The role of has been demonstrated in different nosocomial infections. An increasing number of publications have demonstrated its virulence in the respiratory tract, especially in the immunosuppressed patient population. The number of these patients has increased significantly during the COVID-19 pandemic. Read More

J Appl Microbiol 2022 Jun 23. Epub 2022 Jun 23.

Bio-Safety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea.

Aims: This study aimed to investigate the molecular characterization and antimicrobial susceptibility of C. pseudotuberculosis from skin abscesses of Korean native black goats (KNBG, Capra hircus coreanae) in South Korea.

Methods And Results: A total of 83 isolates were recovered from skin abscesses of KNBG. Read More

Front Biosci (Schol Ed) 2022 Apr;14(2):11

Department of Biology and General Genetics, Institute of Medicine, RUDN University, 117198 Moscow, Russia.

The search for new antimicrobials is essential to address the worldwide issue of antibiotic resistance. The present work aimed at assessing the antimicrobial activity of L. (horse chestnut) bark against bacteria involved in urinary tract infections (UTIs). Read More

Curr Opin Infect Dis 2022 06;35(3):215-222

Department of Pediatric Infectious Diseases and Immunology.

Purpose Of Review: The respiratory microbiota has a role in respiratory tract infection (RTI) pathogenesis. On the mucosa, the respiratory microbiota interacts with potential pathogenic viruses, bacteria and the host immune system, including secretory IgA (sIgA). This review discusses the role of the respiratory microbiota and its interaction with the (mucosal) immune system in RTI susceptibility, as well as the potential to exploit the microbiota to promote health and prevent RTIs. Read More

Front Microbiol 2022 17;13:871627. Epub 2022 May 17.

Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), Marseille, France.

While populations at risk for severe SARS-CoV-2 infections have been clearly identified, susceptibility to the infection and its clinical course remain unpredictable. As the nasopharyngeal microbiota may promote the acquisition of several respiratory infections and have an impact on the evolution of their outcome, we studied the nasopharyngeal microbiota of COVID-19 patients in association with baseline disease-related clinical features compared to that of patients tested negative. We retrospectively analyzed 120 nasopharyngeal pseudonymized samples, obtained for diagnosis, divided into groups (infected patients with a favorable outcome, asymptomatic, and deceased patients) and patients tested negative for SARS-CoV-2, by using Illumina-16S ribosomal ribonucleic acid (rRNA) sequencing and specific polymerase chain reaction (PCR) targeting pathogens. Read More

Sci Rep 2022 Jun 1;12(1):9106. Epub 2022 Jun 1.

Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, Sao Paulo, SP, 05508-270, Brazil.

Purulent vulvar discharges, primarily caused by genito-urinary tract infections, are an important source of economic loss for swine producers due to sow culling and mortality. However, the agents that compose the vaginal microbiota of sows and their changes during infections are not well understood. The first goal of this study was to characterize and compare the vaginal bacterial content of healthy (HE, n = 40) and purulent vulvar discharge sows (VD, n = 270) by a culture-dependent method and MALDI-TOF MS identification. Read More

Infect Dis Rep 2022 May 12;14(3):383-390. Epub 2022 May 12.

Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, ARNAS Garibaldi Hospital, University of Catania, 95122 Catani, Italy.

Bacterial infections, especially those in hospital settings, represent a major complication of COVID-19 patients, complicating management and worsening clinical outcomes. is a non-diphtheric actinobacterium that has been reported as being the causative agent of several different infections, affecting both immunocompetent and immunocompromised patients. Recently, has been recognized as a nosocomial pathogen that is responsible for severe infection in critical patients, as well as in fragile and immunocompromised subjects. Read More

Br J Dermatol 2022 May 28. Epub 2022 May 28.

A*STAR Skin Research Labs, Agency for Science, Technology and Research, Singapore.

Background: The ichthyoses are rare genetic keratinizing disorders that share the characteristics of an impaired epidermal barrier and increased risk of microbial infections. Although ichthyotic diseases share a Th17 immune signature, including increased expression of antimicrobial peptides, the skin microbiota of ichthyoses is virtually unexplored.

Objectives: To analyze the metagenome profile of skin microbiome for major congenital ichthyosis subtypes. Read More

Antibiotics (Basel) 2022 May 12;11(5). Epub 2022 May 12.

Department of Medicine Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.

() is an emerging multidrug-resistant (MDR) pathogen associated with nosocomial infections. In this scenario, we screened the antimicrobial activity of the anthelmintic drugs doramectin, moxidectin, selamectin and niclosamide against 20 MDR clinical isolates. Among these, niclosamide was the best performing drug against . Read More

Animals (Basel) 2022 May 19;12(10). Epub 2022 May 19.

Chemical and Veterinary Analysis Agency Stuttgart (CVUAS), Schaflandstr. 3/3, 70736 Fellbach, Germany.

() is a pathogen primarily known for infections in equine foals, but is also present in numerous livestock species including New World camelids. Moreover, is considered an emerging zoonotic pathogen. In this report, we describe in detail a fatal rhodococcal infection in an alpaca (), to our best knowledge, for the first time. Read More

Klin Lab Diagn 2022 May;67(5):296-300

G.N. Gabrichevsky Research Institute of Epidemiology and Microbiology.

The results of evaluating the effectiveness of C. diphtheriae inoculation using different types of dry swabs in studies simulating various conditions of its storage at the preanalytical stage of a laboratory study for diphtheria are presented. A typical toxigenic strain of C. Read More

Emerg Infect Dis 2022 06;28(6):1257-1260

Toxigenic Corynebacterium ulcerans is as an emerging zoonotic agent of diphtheria. We describe the zoonotic transmission of diphtheria caused by toxigenic C. ulcerans from domestic animals in Spain, confirmed by core-genome multilocus sequence typing. Read More

Infect Dis Ther 2022 May 21. Epub 2022 May 21.

Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.

Introduction: Fracture-related infections (FRIs) are challenging for orthopedic surgeons, as conventional surgical treatment and systemic antimicrobial therapy cannot completely control local infections. Continuous local antibiotic perfusion (CLAP) is a novel and innovative therapy for bone and soft-tissue infections, and is expected to eradicate biofilms by maintaining a sustained high concentration of antimicrobial agents at the infected site. If CLAP therapy can eradicate infection even in cases with implants while preserving the implants, it would be an ideal and effective treatment for local refractory infections. Read More

Front Immunol 2022 3;13:872542. Epub 2022 May 3.

Hengyang Medical School, University of South China, Hengyang, China.

Background: Common vaccinations may have impacts on dementia risk, but current evidence is inconsistent. We therefore investigated the association between vaccinations and dementia risk by systematic review and meta-analysis approach.

Methods: We conducted an extensive search of PubMed, Embase, Cochrane Library, and Web of Science to identify studies that compared the risk of dementia in vaccinated versus unvaccinated populations. Read More

Microbiol Spectr 2022 Jun 17;10(3):e0195621. Epub 2022 May 17.

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing, China.

Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease responsible for many infections worldwide. Differences in respiratory microbiota may correlate with disease severity. Samples were collected from 20 severe and 51 mild COVID-19 patients. Read More

Microbes Infect 2022 May 12:105001. Epub 2022 May 12.

Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Av. 28 de Setembro, 87, Fundos, 3º andar, Vila Isabel, 20551-030, Rio de Janeiro, RJ, Brazil. Electronic address:

For many years, the potential pathogenic of non-diphtheriae corynebacteria were underestimated. Nowadays, a growing number of Corynebacterium species are recognized as opportunistic agents of human infections, mainly in hospital settings. In addition, multidrug-resistant Corynebacterium isolates from clinical specimens, have been reported and the role of Corynebacterium spp. Read More

J Anim Sci 2022 Jun;100(6)

Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA.

Subclinical mastitis is a common intramammary disease in sheep production systems. Expenses associated with compromised animal performance, therapeutic interventions, and decreased ewe longevity make efforts to minimize its prevalence worthwhile. The objectives of this study were to 1) quantify the prevalence of subclinical mastitis throughout lactation, 2) evaluate the impact of bedding treatments on subclinical mastitis during early lactation, 3) evaluate the efficacy of prophylaxis and feed restriction during weaning on subclinical mastitis cure rates, and 4) identify levels and types of antimicrobial resistance in milk-derived bacteria. Read More

Lancet Microbe 2021 08 26;2(8):e386-e396. Epub 2021 May 26.

Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Paris, France; National Reference Center for Corynebacteria of the Diphtheriae Complex, Institut Pasteur, Paris, France. Electronic address:

Background: An outbreak of diphtheria, declared in Yemen in October, 2017, is ongoing. We did a cross-sectional study to investigate the epidemiological, clinical, and microbiological features of the outbreak.

Methods: Probable cases of diphtheria that were defined clinically and recorded through a weekly electronic diseases early warning system (from 2017, week 22, to 2020, week 17) were used to identify trends of the outbreak (we divided the epidemic into three time periods: May 29, 2017, to June 10, 2018; June 11, 2018, to June 3, 2019; and June 4, 2019, to April 26, 2020). Read More

Int Med Case Rep J 2022 3;15:231-234. Epub 2022 May 3.

Department of Pediatrics, Okinawa Prefectural Nanbu Medical Center and Children's Medical Center, Okinawa, 901-1193, Japan.

, a common component of the skin and mucosal microbiota of both immunocompetent and immunocompromised individuals, has become an emerging pathogen, colonizing indwelling medical devices and causing infections at multiple sites. A 3-year-old boy with an Ommaya reservoir in the right ventricle and a medical history of grade 3 intraventricular hemorrhage, Hirschsprung disease, catheter-related methicillin-resistant bacteremia, and congenital central hypoventilation syndrome was hospitalized for Ommaya reservoir infection with . He was treated with ampicillin, to which the initial isolate was susceptible. Read More

Sci Total Environ 2022 Sep 6;837:155782. Epub 2022 May 6.

Nicholas School of Environment, Duke University, 9 Circuit Drive, Box 90328, Durham, NC 27708, USA; Children's Health & Discovery Initiative, Duke School of Medicine, Chesterfield Building, 701 W. Main St., Durham, NC 27710, USA. Electronic address:

Organophosphate esters (OPEs) are commonly applied as flame retardants and plasticizers. Toxicological studies suggest exposure effects on immune endpoints, raising concerns as infants' OPE exposures are elevated compared to older children and adults due to hand-to-mouth behavior and breastfeeding. Here, we sought to evaluate the immune responsiveness of infants to a neoantigen (e. Read More

J Immunol Res 2022 29;2022:4593598. Epub 2022 Apr 29.

Medico Cura Te Stesso Onlus, Modena, Italy.

Aim: We report an open spontaneous anecdotical retrospective survey of administration to 4000 fragile immune-depressed and multimorbid patients treated with a killed strain to enhance innate immunity, integrating the adaptative immune response for long-standing antinfectious resistance.

Methods: A total of 4000 patients (1900 men and 2100 women) with mild, moderate, or chronic disease, appealing to our Second Opinion Medical Consultation Network, signed an informed consent form and were injected subcutaneously with . The treatment was followed up to 6 months, completing the short form of the medical outcome health survey questionnaire (SF-36) directly by the patients or their parents and monitoring their health status regularly via telemedicine (Skype, WhatsApp, mail, etc. Read More

BMC Surg 2022 May 4;22(1):156. Epub 2022 May 4.

Joint Orthopaedic Research Center of Zunyi Medical University and University of Rochester Medical Center, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China.

Background: Relapsed childhood polymicrobial osteomyelitis associated with dermatophytosis has not been reported in the literature.

Case Presentation: Here we report on a case of a 45-year-old man who had left tibial osteomyelitis for 29 years, accompanied by skin fungal infection of the ipsilateral heel for 20 years, and underwent a second operation due to recurrence of polymicrobial infection 6 years ago. The patient had a history of injury from a rusty object, which penetrated the anterior skin of the left tibia middle segment causing subsequent bone infection, but was asymptomatic after receiving treatments in 1983. Read More

Rev Chilena Infectol 2021 10;38(5):689-690

Escuela de Medicina, Pontificia Universidad Católica de Chile, Chile.

Microbiol Resour Announc 2022 May 4;11(5):e0000822. Epub 2022 May 4.

Institut Méditerranée-Infection, Marseille, France.

In 2018, Corynebacterium sanguinis strain Marseille-P8776 was isolated from the blood of a 64-year-old woman suffering from breast cancer who had undergone chemotherapy and radiotherapy. Following whole-genome sequencing, the chromosome of strain Marseille-P8776 was 2,613,836 bp long with a G+C content of 64.92%, 2,568 protein-coding genes, and 64 RNA genes. Read More

Eur J Med Res 2022 May 3;27(1):63. Epub 2022 May 3.

Department of Internal Medicine II, Center for Complementary Medicine, Faculty of Medicine, University of Freiburg, 79106, Freiburg, Germany.

Background: Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by low platelet counts and increased bleeding risk. The disease may be induced by other disorders, including malignancies, autoimmune diseases, infectious agents or drugs. However, ITP has also been described following vaccinations, such as the measles-mumps-rubella vaccination. Read More

Cureus 2022 Mar 28;14(3):e23579. Epub 2022 Mar 28.

Emergency Department, St. Barnabas Hospital (SBH) Health System, Bronx, USA.

Recognizing life-threatening infections is crucial for an emergency physician. In this case report, we describe an atypical presentation of a severe, infiltrating kidney infection, which, if not recognized early, could have led to a detrimental outcome. Emphysematous pyelitis, which is class I of emphysematous pyelonephritis, is a rare entity, and patients may present with a urinary tract infection or pyelonephritis. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2022 Apr;56(4):427-432

Institute of Pathogenic Microbiology of Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 510000, China Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences, Guangzhou 510000, China.

To identify and analyze two strains of in Guangdong Province by combining whole genome sequencing with traditional detection methods. The was isolated from Guangzhou in 2010 and Zhuhai in 2020 respectively. Isolates were identified by API Coryne strips and MALDI-TOF-MS. Read More