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Cureus 2021 May 10;13(5):e14947. Epub 2021 May 10.

Microbiology: Hospital Infection Control, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

usually causes respiratory diphtheria, which is considered as a disease of toxemia but never bacteremia. Over the last few decades, cutaneous diphtheria has been increasingly reported owing to the emergence of the non-toxigenic strain, which causes locally necrotic and ulcerative lesions. Bacteremia is very rare, but the existing evidence in the literature suggests that the organism can rarely cause invasive infections such as septicemia, endocarditis, and osteoarthritis. Read More

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Respiratory Medicine, Prince Philip Hospital, Llanelli, UK.

We describe a unique case of a patient with acute myeloid leukaemia (AML), with recurring infections during chemotherapy from chronic nasal carriage of non-diphtherial Corynebacterium, who was eventually diagnosed as she presented with neutropaenic sepsis. Identifying (often multiple) sources of infection in immunocompromised patients is crucial but deciding whether multiple organisms, which in health are considered as commensals, are actually pathogenic during vulnerable states-can be clinically difficult. Our case highlights the efforts to correctly identify the actual source of this rare organism and the recognition of its pathogenic potential when other illnesses present. Read More

mSystems 2021 Jun 8:e0032021. Epub 2021 Jun 8.

Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom.

Yellow-eyed penguins, Megadyptes antipodes, are an endangered species that are endemic to New Zealand. Outbreaks of diphtheritic stomatitis have caused significant mortality for this species, especially among young chicks. In this study, we isolated 16 sp. Read More

mBio 2021 Jun 8:e0068221. Epub 2021 Jun 8.

Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.

Members of the suborder of bacteria, including major pathogens such as Mycobacterium tuberculosis, grow via the insertion of new cell wall peptidoglycan (PG) material at their poles. This mode of elongation differs from that used by Escherichia coli and other more well-studied model organisms that grow by inserting new PG at dispersed sites along their cell body. Dispersed cell elongation is known to strictly require the SEDS-type PG synthase called RodA, whereas the other major class of PG synthases called class A penicillin-binding proteins (aPBPs) are not required for this mode of growth. Read More

Cureus 2021 May 24;13(5):e15206. Epub 2021 May 24.

Pathology, Giresun University Faculty of Medicine, Giresun, TUR.

Since idiopathic granulomatous lobular mastitis, also known as idiopathic granulomatous mastitis or granulomatous lobulitis, was first described by Kessler and Wolloch in 1972, no consensus on the ideal and definitive treatment for this phenomenon has been reached thus far. Idiopathic granulomatous lobular mastitis mostly frequently observed in women of childbearing age within a few years of pregnancy with a higher incidence in patients of Hispanic, Native American, Middle Eastern, and African descent. This entity, , is a rare, benign, chronic inflammatory breast condition of unknown aetiology mimicking two common breast disorders. Read More

Nihon Ronen Igakkai Zasshi 2021 ;58(2):297-302

Department of Diabetes, Metabolism and Endocrinology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology.

An 87-year-old woman diagnosed with dementia with Lewy bodies (DLB) 2 years earlier was referred to our institution because of difficulty walking. She was diagnosed with urinary tract infection and admitted to our hospital. During hospitalisation, she became delirious, which prompted the administration of haloperidol. Read More

Nat Commun 2021 05 17;12(1):2871. Epub 2021 May 17.

University of Turku, Turku, Finland.

Reported incidence of pertussis in the European Union (EU) and the European Economic Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection against diphtheria and tetanus seems sufficient. We aimed to determine the seroprevalence of DTP antibodies in EU/EEA countries within the age groups of 40-49 and 50-59 years. Eighteen countries collected around 500 samples between 2015 and 2018 (N = 10,302) which were analysed for IgG-DTP specific antibodies. Read More

Microbiol Resour Announc 2021 Apr 29;10(17). Epub 2021 Apr 29.

Department of Biomedicine, Aarhus University, Aarhus, Denmark

is a slow-growing, lipid-requiring bacterium that may cause ocular infections. Here, we report the complete genome sequences of two strains, T160811 and T180208, isolated from infectious keratitis. The two genomes consist of circular chromosomes of 2,431,961 bp and 2,481,998 bp, respectively, and contain high numbers of repetitive elements. Read More

Microorganisms 2021 Apr 23;9(5). Epub 2021 Apr 23.

Scabies Laboratory, Infectious Diseases Program, Biology Department, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.

Epidemiological studies link infection and impetigo. Scabies mites can promote (Group A ) and infections by breaching the skin barrier and excreting molecules that inhibit host innate immune responses. However, little is known about the composition and the function of the scabies-associated microbiota. Read More

Monoclon Antib Immunodiagn Immunother 2021 Apr;40(2):36-49

National Institute of Animal Biotechnology, Hyderabad, India.

The dawn of the 20th century saw the formative years of developments in immunology. In particular, immunochemistry, specifically pertaining to antibodies, was extensively studied. These studies laid the foundations for employing antibodies in a variety of ways. Read More

Microb Pathog 2021 Jun 21;155:104887. Epub 2021 Apr 21.

BIOMEDAGE Group. Faculty of Medicine. Cantabria University, Santander, Spain; Instituto de Investigación Valdecilla (IDIVAL). Santander, Spain.

Corynebacterium striatum is a nosocomial pathogen which is increasingly associated with serious infections in both immunocompetent and immunocompromised patients. However, little is known about virulence factors and mechanisms that may enhance the establishment and long-term survival of Corynebacterium striatum. in the hospital environment. Read More

Respir Res 2021 Apr 23;22(1):118. Epub 2021 Apr 23.

Division of Infection Medicine, Hospital of Helsingborg, Helsingborg, Sweden.

Background: Lung transplant (LTx) recipients are at increased risk for airway infections, but the cause of infection is often difficult to establish with traditional culture-based techniques. The objectives of the study was to compare the airway microbiome in LTx patients with and without ongoing airway infection and identify differences in their microbiome composition.

Methods: LTx recipients were prospectively followed with bronchoalveolar lavage (BAL) during the first year after transplantation. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Apr;55(4):521-527

Nanshan District Center for Disease Control and Prevention, Department of Microbiology, Shenzhen 518054, China.

The purpose of this study was to investigate the IgG antibody levels of whooping cough, diphtheria, and tetanus in pregnant women in Nanshan District. From January to March 2019, 495 pregnant women who met the inclusion criteria in a hospital in Nanshan District, Shenzhen were selected as the survey subjects. The enzyme-linked immunosorbent assay was used to detect serum levels of pertussis, diphtheria, and tetanus IgG antibodies and we compared the differences in antibody levels of pregnant women with different characteristics. Read More

Wiad Lek 2021 ;74(1):137-143

UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE.

Objective: The aim: Of the paper is to analyze the current views on diagnosis and management of diphtheria in children.

Patients And Methods: Materials and methods: The data of scientific literature have been analyzed, using the bibliosemantic method of study.

Conclusion: Conclusions: The specific prophylaxis is recommended to prevent the infection. Read More

Comp Med 2021 Apr 8. Epub 2021 Apr 8.

Corynebacterium bovis, the causative agent of hyperkeratotic dermatitis in immunodeficient mice, is a significant problemin preclinical oncology research. Infection results in lifelong skin colonization and a decrease in successful engraftment ofpatient-derived xenograft tumor models. The use of antimicrobial agents for C. Read More

Vaccine 2021 04 3;39(18):2506-2516. Epub 2021 Apr 3.

CBG-MEB, Graadt van Roggenweg 500, 3531 AH Utrecht, the Netherlands. Electronic address:

For batch release of legacy vaccines such as DTaP, in vivo potency release assays are required. We quantified the variability of in vivo potency release assays for four DTaP (Diphtheria, Tetanus, acellular Pertussis) products of different manufacturers. With their large CV (Coefficients of Variance) ranging from 16% to 132%, these in vivo assays are of limited value to ensure their potency is consistent and similar to the clinical batches used for the marketing authorisation. Read More

Vaccine 2021 04 2;39(18):2568-2574. Epub 2021 Apr 2.

Laboratório de Biotecnologia Infecto-parasitária, Universidade Federal de Pelotas (UFPel), Campus Universitário s/n, Capão do Leão 96160-000, RS, Brazil. Electronic address:

Purpose: rCP01850, rCP09729 and rCP00660 proteins from Corynebacterium pseudotuberculosis, predicted as the three best targets to be used in vaccines against Caseous Lymphadenitis in mature epitope density (MED) analysis were tested as vaccinal targets in association to saponin as adjuvant.

Methodology: rCP00660, rCP09720 and rCP01850 were expressed in E. coli and purified for immunization assay. Read More

Int J Mol Sci 2021 Mar 29;22(7). Epub 2021 Mar 29.

Microbiology Division, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.

is a newly identified animal pathogen of forest animals such as roe deer and wild boars. The species is closely related to the emerging human pathogen and the widely distributed animal pathogen . In this study, strain W25 was characterized with respect to its interaction with human cell lines. Read More

Cornea 2021 06;40(6):774-779

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.

Purpose: To characterize diphtheroid corneal infections in eyes in the chronic phase of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).

Methods: Observational case series.

Results: Four eyes of 3 patients were included in this review. Read More

J Med Microbiol 2021 Mar 18;70(3). Epub 2021 Mar 18.

Service de Bactériologie-Hygiène hospitalière, CHU de Rennes, Rennes, France.

Even though has been described in 2002, this species has long been underestimated due to the unreliability of conventional identification methods and only a few cases of infections have been reported. Little is known about clinical significance and antimicrobial susceptibility profile of this uncommon species. To evaluate the clinical relevance of and its antimicrobial susceptibility profile. Read More

J Appl Microbiol 2021 Mar 16. Epub 2021 Mar 16.

Research Group of Physiology and Genetics of Hydrobionts, Institute of Systematics and Ecology of Animals of Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.

Aims: The aim of the study was to investigate the skin microbiota of Prussian carp infested by ectoparasites from the genera Argulus and Lernaea.

Methods And Results: Associated microbiota of skin of Prussian carp and ectoparasites were investigated by sequencing of the V3, V4 hypervariable regions of 16S rRNA using Illumina MiSeq sequencing platform.

Conclusions: According to the Spearman rank correlation test, the increasing load of ulcerations of the skin of Prussian carp was weakly negatively correlated with reduction in the abundance of the following taxa: Acrobacter, bacteria C39 (Rhodocyclaceae), Rheinheimera, Comamonadaceae, Helicobacteraceae and Vogesella. Read More

Nat Commun 2021 03 8;12(1):1500. Epub 2021 Mar 8.

Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.

Diphtheria is a respiratory disease caused by the bacterium Corynebacterium diphtheriae. Although the development of a toxin-based vaccine in the 1930s has allowed a high level of control over the disease, cases have increased in recent years. Here, we describe the genomic variation of 502 C. Read More

Vaccine 2021 03 4;39(13):1818-1825. Epub 2021 Mar 4.

Department of Bacteriology and Immunology, University of Helsinki, PO BOX 21 (Haartmaninkatu 3), FI-00014 Helsinki, Finland; Translational Immunology Research Program, University of Helsinki, PO. Box 63 (Haartmaninkatu 8), FI-00014 Helsinki, Finland.

Persistence of immune memory in humans is a crucial yet poorly understood aspect of immunology. Here we have studied the effect of Puumala hantavirus infection on unrelated, pre-existing immune memory by studying T cell- and antibody responses against toxoid vaccine antigens of diphtheria, tetanus and pertussis in a cohort of 45 patients. We found that tetanus- and pertussis -specific IgG concentrations elevate during acute Puumala virus infection. Read More

Front Cell Infect Microbiol 2020 16;10:610781. Epub 2021 Feb 16.

Animal Science College, Tibet Agriculture & Animal Husbandry University, Linzhi, China.

Domestic yaks () are indigenous to the Tibetan Plateau and display a high diarrhea rate due to poor habitat and husbandry conditions. has been shown to exert beneficial effects as antimicrobial, growth promotion, and gut microbiota in humans and/or murine models, but the relevant data regarding isolated from yaks was unavailable. Therefore, this study aimed to investigate the effects of from yaks on the intestinal microbial community in a mouse model and determine whether supplementation contributed in alleviating diarrhea by modulating gut microbiota. Read More

J Dairy Sci 2021 May 2;104(5):5979-5987. Epub 2021 Mar 2.

Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, the Netherlands. Electronic address:

Mastitis is an important problem in meat-producing sheep, but few studies have investigated the transmission dynamics of mastitis pathogens in these animals. The objective of this study was to describe the pathogens causing intramammary infections (IMI) in suckler ewes, their effect on somatic cell count, and the dynamics of these IMI in early lactation. We enrolled 15 sheep flocks early after lambing and selected ewes in each flock that were sampled twice with a 3-wk interval. Read More

Appl Microbiol Biotechnol 2021 Mar 2;105(6):2287-2296. Epub 2021 Mar 2.

Laboratório de Biotecnologia Infecto-Parasitária, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Campus Universitário s/n, Prédio 19-, Pelotas, RS, 96010-900, Brazil.

Caseous lymphadenitis (CLA) is an infectious chronic disease responsible for economic losses in sheep and goat breeding worldwide. CLA has no effective treatment, evidencing the vaccination schedule as the best control strategy. Although some commercial vaccines have been available, none of them provides total protection, which is sometimes insufficient and does not reach the same efficiency when compared in sheep and goats. Read More

Dtsch Arztebl Int 2020 Dec;117(51-52):888

J Wildl Dis 2021 01;57(1):225-229

Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Dr. NW, Calgary, Alberta, Canada T2N 4Z6.

A wild muskox (Ovibos moschatus) with dermatitis typical of contagious ecthyma had secondary bacterial septicemia with Corynebacterium freneyi that included laminitis, hepatitis, and suppurative encephalitis. This case supports the association between orf virus infection and fatal secondary infections, which may have contributed to population declines on Victoria Island, Canada. Read More

Rev Argent Microbiol 2021 Feb 21. Epub 2021 Feb 21.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Laboratorio de Bacteriología, Catedra de Microbiología Clínica, Hospital de Clínicas José de San Martin, Buenos Aires, Argentina. Electronic address:

Corynebacterium kroppenstedtii is an immobile, non-sporulated, glucose-fermenting and lipophilic gram-positive rod of the skin microbiota. In recent years, numerous isolates of this species have been reported mainly in breast infections, such as abscesses and granulomatous mastitis. We present here four cases of C. Read More

Arch Microbiol 2021 Jul 24;203(5):1863-1880. Epub 2021 Feb 24.

Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Faculty of Medical Sciences, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Corynebacterium striatum is part of microbiota of skin and nasal mucosa of humans and has been increasingly reported as the etiologic agent of community-acquired and nosocomial diseases. Antimicrobial multidrug-resistant (MDR) C. striatum strains have been increasingly related to various nosocomial diseases and/or outbreaks worldwide, including fatal invasive infections in immunosuppressed and immunocompetent patients. Read More