1,191 results match your criteria Corticosteroid-Induced Myopathy
Lupus 2018 Nov 22:961203318814196. Epub 2018 Nov 22.
2 Department of Ophthalmology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Objective: The aim of this study was to conduct a detailed ophthalmological examination in children with systemic lupus erythematosus (jSLE), including choroidal thickness (ChT), choroidal vascularity index (CVI) and peripapillary retinal nerve fiber layer (RNFL).
Methods: The study included all jSLE patients ( n = 21) diagnosed according to the Systemic Lupus International Collaborating Clinics classification criteria between January 2017 and April 2017, and an age- and gender-matched control group ( n = 21). The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) was used to assess disease activity. Read More
J Neurol Sci 2018 Oct 19;396:8-11. Epub 2018 Oct 19.
Department of Neurology, Graduate School of Medicine, Chiba University, Japan.
Background: Initial worsening of symptoms after the start of corticosteroid administration is a major concern in the treatment of myasthenia gravis (MG). However, the risk factors or specific patient backgrounds related to this issue have not been fully understood. We aimed to determine the risk factors and developed a scoring system for predicting initial worsening in generalized MG. Read More
Clin Cancer Res 2018 Sep 17. Epub 2018 Sep 17.
Department of Radiology, Pediatric Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
Osteonecrosis is a devastating complication of high-dose corticosteroid therapy in patients with cancer. Core decompression for prevention of bone collapse has been recently combined with the delivery of autologous concentrated bone marrow aspirates. The purpose of our study was to develop an imaging test for the detection of transplanted bone marrow cells in osteonecrosis lesions. Read More
Dermatol Surg 2018 Sep 7. Epub 2018 Sep 7.
Department of Dermatology, China Medical University Hospital, China Medical University, Taichung, Taiwan Department of Dermatology, China Medical University Hospital, Taichung, Taiwan School of Medicine, China Medical University, Taichung, Taiwan.
Am J Hosp Palliat Care 2018 Aug 30:1049909118797283. Epub 2018 Aug 30.
4 Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Background: Corticosteroids are frequently utilized in the palliative care setting to combat symptoms such as fatigue, dyspnea, pain, weakness, anorexia, cachexia, nausea, and vomiting. Often times, adverse effects arise with corticosteroid use, and it is unclear whether switching to another corticosteroid would reduce the risk of specific adverse effects or what measures can be taken to alleviate the adverse effects.
Objective: This article aims to review the differentiating pharmacokinetics, potency, and adverse effect profiles of corticosteroids and summarize their clinical applicability. Read More
Minerva Med 2018 Aug;109(4):300-325
Division of Orthopedics and Traumatology, School of Medical and Pharmaceutical Science, DINOGMI Department, Section of Orthopedic Rehabilitation, University of Genoa, Genoa, Italy.
Introduction: Clodronic acid is a non-nitrogen-containing bisphosphonate largely used from some decades in the prevention and treatment of postmenopausal and secondary osteoporosis. In addition to antiresorptive activity, clodronate has shown anti-inflammatory and analgesic properties, and modulatory effects on bone and cartilage metabolism.
Evidence Acquisition: A literature review has been conducted to characterize the mechanism of action of clodronate and to retrieve available evidence about the use of clodronate in primary and secondary osteoporosis, and its potential role in other musculoskeletal conditions and orthopedic surgery. Read More
Acta Dermatovenerol Croat 2018 Apr;26(1):61-63
Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More
Dermatol Surg 2018 May 16. Epub 2018 May 16.
Dermatology Department, Naval Medical Center San Diego, San Diego, California Dermatology Department, Hospital Americano Base Naval de Rota, Cádiz, Spain.
Klin Monbl Augenheilkd 2018 May 8;235(5):586-591. Epub 2018 May 8.
Zentrum für Augenheilkunde, Universität zu Köln.
Topical corticosteroids are effective anti-inflammatory drugs in the treatment of anterior uveitis. The intraocular efficacy of topical corticosteroids mostly depends on their intraocular permeability through the cornea. Lipophile derivatives such as dexamethasone and prednisolone acetate penetrate better into the anterior chamber than hydrophilic derivatives. Read More
Horm Behav 2018 May 10. Epub 2018 May 10.
Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Denver Veterans Affairs Medical Center (VAMC), Denver, CO 80220, USA; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), Denver, CO 80220, USA. Electronic address:
Contribution to Special Issue on Fast effects of steroids. Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses. In addition to these classical genomic effects, corticosteroid hormones also exert rapid actions on physiology and behavior through a variety of non-genomic mechanisms, some of which involve GR or MR, and others of which are independent of these receptors. Read More
Ann Endocrinol (Paris) 2018 Jun 21;79(3):115-118. Epub 2018 Apr 21.
Rheumatology department, Cochin Hospital, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Electronic address:
Corticosteroid-induced osteoporosis is the most common form of secondary osteoporosis and the most frequent cause of osteoporosis in young people. Bone loss and fracture risk increase rapidly after the initiation of corticosteroid therapy and are proportional to dose and treatment duration. The increase in fracture risk is not fully assessed by bone mineral density measurement, as it is also related to impaired bone quality and increased risk of falls. Read More
J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):2014-2023.e2. Epub 2018 Apr 21.
Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland. Electronic address:
Background: Treatment of severe asthma may include high-dose systemic corticosteroid therapy, which is associated with substantial comorbidity. There is evidence to suggest that this burden is not evenly distributed across age, sex, and corticosteroid exposure levels.
Objective: To examine the associations between age, sex, comorbidity, and patterns of health care cost across groups differentiated by corticosteroid exposure. Read More
Case Rep Ophthalmol Med 2018 19;2018:7419823. Epub 2018 Feb 19.
Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Purpose: To report the successful utilization of adjunctive repeat intravitreal corticosteroid therapy for the treatment of cystoid macular edema in syphilis-related uveitis.
Methods/patients: An HIV-positive patient with treated ocular syphilis who developed refractory cystoid macular edema (CME) was treated with repeat intravitreal corticosteroid therapy including dexamethasone intravitreal implants.
Results: Treatment led to the resolution of CME and improvement in visual acuity. Read More
J Orthop Translat 2018 Jan 14;12:36-44. Epub 2017 Dec 14.
Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, The Chinese University of Hong Kong, Hong Kong SAR, China.
Background/objective: This is a multicentre, randomised, double-blind, placebo-controlled clinical trial to investigate the safety and efficacy of Chinese herbal Fufang Xian Ling Gu Bao (XLGB) with antiadipogenic compounds for the prevention of corticosteroid (CS)-induced osteonecrosis of femoral head (ONFH).
Methods: Patients of both genders, aged between 18 and 65 years, with diseases such as systemic lupus erythematosus, nephrosis, dermatosis and rheumatoid arthritis indicated for CS treatment and who did not show magnetic resonance imaging of ONFH at baseline were recruited into the study and then randomised into either XLGB group (n = 129) with daily oral administration of XLGB or placebo group (n = 146).
Results: Magnetic resonance imaging revealed a total of 30 ONFH cases at 6 months after CS treatment, with 6. Read More
J Child Adolesc Psychopharmacol 2018 Jun 11;28(5):354-359. Epub 2018 Apr 11.
Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine , Miami, Florida.
Objectives: Iatrogenic steroid-induced psychosis is a rare but serious adverse side effect seen largely in the adult population that less commonly affects children and adolescents. Given the significant distress steroid-induced psychosis may cause, recommendations are needed for effective management. Here we conducted a systematic review of the literature and report a new case of steroid-induced psychosis in a 12-year-old patient. Read More
Am J Physiol Regul Integr Comp Physiol 2018 Aug 6;315(2):R312-R322. Epub 2018 Apr 6.
Department of Biology, York University , Toronto, Ontario , Canada.
Molecular physiology of the tricellular tight junction (tTJ)-associated proteins lipolysis-stimulated lipoprotein receptor ( lsr, = angulin-1) and an immunoglobulin-like domain-containing receptor ( ildr2, ≈angulin-3) was examined in model trout gill epithelia. Transcripts encoding lsr and ildr2 are broadly expressed in trout organs. A reduction in lsr and ildr2 mRNA abundance was observed during and after confluence in flask-cultured gill cells. Read More
Clin Orthop Relat Res 2018 May;476(5):1129-1130
M. T. Houdek, C. C. Wyles, R. J. Sierra, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA M. S. Collins, B. M. Howe, Department of Radiology, Mayo Clinic, Rochester, MN, USA A. Terzic, A. Behfar, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Clin Orthop Relat Res 2018 May;476(5):1126-1128
N. S. Piuzzi, Orthopaedic Regenerative Medicine and Cellular Therapies Clinical Scholar, Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA, and Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Lancet Respir Med 2018 06 15;6(6):442-450. Epub 2018 Mar 15.
Wolfson Centre for Personalised Medicine, Medical Research Council (MRC) Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK. Electronic address:
Background: A serious adverse effect of corticosteroid therapy is adrenal suppression. Our aim was to identify genetic variants affecting susceptibility to corticosteroid-induced adrenal suppression.
Methods: We enrolled children with asthma who used inhaled corticosteroids as part of their treatment from 25 sites across the UK (discovery cohort), as part of the Pharmacogenetics of Adrenal Suppression with Inhaled Steroids (PASS) study. Read More
Int Orthop 2018 Jul 17;42(7):1491-1498. Epub 2018 Mar 17.
Department of Orthopaedics, Pediatric Orthopaedics and Traumatology, Medical Centre of Postgraduate Education, Warsaw-Otwock, ul. Konarskiego 13, 05-400, Otwock, Poland.
Introduction: The aim of the study was to assess the factors influencing the final results of treatment of the femoral head osteonecrosis (ONFH) with core decompression and bone substitute grafting. The special interest was focused on comparison between alcohol- and steroid-induced ONFHs.
Material And Methods: In this prospective study, a total of 53 patients (58 hips) in the mean age of 35. Read More
Clin Orthop Relat Res 2018 Feb;476(2):398-399
T. P. Vail, James L. Young Professor and Chairman, Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA.
Clin Orthop Relat Res 2018 Feb;476(2):388-397
M. T. Houdek, C. C. Wyles, R. J. Sierra, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA M. S. Collins, B. M. Howe, Department of Radiology, Mayo Clinic, Rochester, MN, USA A. Terzic, A. Behfar, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Background: Randomized trials have shown the benefits of injecting bone marrow-derived mesenchymal stem cells (BmMSCs) after standard hip decompression in patients with osteonecrosis of the femoral head. However, the combination of BmMSCs and platelet-rich plasma (PRP) injected into the femoral head after decompression has not been reported previously. This study reports the results in a preliminary series of patients with osteonecrosis of the femoral head treated with BmMSCs plus PRP. Read More
Australas Psychiatry 2018 Oct 15;26(5):520-523. Epub 2018 Feb 15.
Asssociate Professor of Psychiatry, Sydney Adventist Medical School, University of Sydney, Sydney, NSW, Australia.
Objectives: The aims of this study are to describe two patients whose manic symptoms persisted for several months after the cessation of corticosteroids, to review the literature and to suggest treatment.
Methods: The presentation of two elderly patients with persistent manic symptoms following cessation of corticosteroids several months previously afforded the author the opportunity to examine them carefully, investigate and treat them.
Results: The patients were investigated to rule out other causes and were treated with sodium valproate and quetiapine (in the second patient). Read More
J Clin Med 2018 Feb 11;7(2). Epub 2018 Feb 11.
Department of Ophthalmology, "Azienda Ospedaliero-Universitaria" "Santa Maria della Misericordia" Hospital of Udine, P.le S. Maria della Misericordia, 15, 33100 Udine, Italy.
Purpose: to present the mid-term results of canaloplasty in a small cohort of corticosteroid glaucoma patients.
Material And Methods: Nine eyes from seven patients with various types of corticosteroid glaucoma in maximum medical therapy underwent canaloplasty. Patients underwent complete ophthalmic examination every six months. Read More
Joint Bone Spine 2018 Oct 31;85(5):641-642. Epub 2018 Jan 31.
Département de rhumatologie, université de Lille, rue Émile-Laine, 59037 Lille, France; PMOI, EA 4490, 59000 Lille, France. Electronic address:
Ann Endocrinol (Paris) 2018 Feb 12;79(1):1-22. Epub 2018 Jan 12.
Service d'endocrinologie diabétologie pédiatrique, hôpital Robert-Debré, centre de référence des maladies endocriniennes rares de la croissance et du développement, université Paris Diderot, Assistance publique-Hôpitaux de Paris, 48, boulevard Sérurier, 75019 Paris, France.
The French endocrinology society (SFE) and the French pediatric endocrinology society (DFSDP) have drawn up recommendations for the management of primary and secondary adrenal insufficiency in the adult and child, based on an analysis of the literature by 19 experts in 6 work-groups. A diagnosis of adrenal insufficiency should be suspected in the presence of a number of non-specific symptoms except hyperpigmentation which is observed in primary adrenal insufficiency. Diagnosis rely on plasma cortisol and ACTH measurement at 8am and/or the cortisol increase after synacthen administration. Read More
Reumatol Clin 2017 Dec 8. Epub 2017 Dec 8.
Rheumatology and Metabolic Bone Diseases Department, Hospital de Santa Maria, CHLN, Lisbon, Portugal.
Subcutaneous fat atrophy and hypopigmentation are potential adverse side effects of local corticosteroid injection that may resolve spontaneously within 1-2 years. This report shows that fat grafting provides a simple, effective and safe correction of corticosteroid induced cutaneous atrophy with very satisfying esthetic and functional results. Read More
Med J Malaysia 2017 Oct;72(5):259-263
Sarawak General Hospital, Department of Obstetrics & Gynaecology, Sarawak, Malaysia.
Background: In the course of managing preterm labour, increasing trends of total white cell count raises concern for the obstetrician, suggesting a possible underlying infectious aetiology. Although mild leukocytosis is expected in pregnancy, the patterns of increment after corticosteroid administration are not well described beyond animal models and in a small number of human studies.
Methods: Seventy-three consecutive patients who required antenatal corticosteroids for either preterm labour or prelabour caesarean section were recruited and given a standard course of 12mg dexamethasone phosphate, twelve hours apart. Read More
Ann Endocrinol (Paris) 2017 Dec 27;78(6):490-494. Epub 2017 Nov 27.
Service des maladies endocriniennes et métaboliques, hôpital Cochin, CHU Paris Centre, 75014 Paris, France.
The prevalence of primary adrenal insufficiency is estimated at between 82-144/million, with auto-immunity being the most common cause in adults and genetic causes, especially enzyme defects, being the most common cause in children. The prevalence of secondary adrenal deficiency is estimated to be between 150-280/million. The most frequent occurrence is believed to be corticosteroid-induced insufficiency, despite the incidence of clinically relevant deficiency after cessation of glucocorticoid treatment being widely debated. Read More
Clin Schizophr Relat Psychoses 2017 Nov 22. Epub 2017 Nov 22.
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA.
Almost fifty percent of patients with schizophrenia experience some type of dermatitis. The standard treatment for dermatitis is a topical corticosteroid. Despite their demonstrated effectiveness, topical corticosteroids are associated with various side effects that may limit their use. Read More
Actas Dermosifiliogr 2018 May 20;109(4):357-358. Epub 2017 Nov 20.
Servicio de Reumatología, Hospital Universitario 12 de Octubre, Madrid, España.
Mol Cell Neurosci 2017 12 26;85:226-234. Epub 2017 Oct 26.
Departments of Pediatrics and Psychiatry, Emory School of Medicine, United States; Molecular and Systems Pharmacology, Emory University, United States; Yerkes National Primate Research Center, Emory University, United States. Electronic address:
Stressor exposure induces neuronal remodeling in specific brain regions. Given the persistence of stress-related illnesses, key next steps in determining the contributions of neural structure to mental health are to identify cell types that fail to recover from stressor exposure and to identify "trigger points" and molecular underpinnings of stress-related neural degeneration. We evaluated dendrite arbor structure on hippocampal CA1 pyramidal neurons before, during, and following prolonged exposure to one key mediator of the stress response - corticosterone (cortisol in humans). Read More
J Matern Fetal Neonatal Med 2017 Oct 29:1-6. Epub 2017 Oct 29.
a Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu , China.
Objective: The present study was undertaken to test the hypothesis that if Cldn18 is associated with lung maturation and play a key role in the corticosteroid-induced expression of surfactant proteins.
Methods: Mouse embryonic lung tissue at different developmental stages (E14.5, E16. Read More
Chin Med J (Engl) 2017 Nov;130(21):2601-2607
Department of Orthopaedic Surgery, Centre for Osteonecrosis and Joint Preserving and Reconstruction, China-Japan Friendship Hospital, Beijing 100029, China.
Objective: This review aimed to provide a current recommendation to multidisciplinary physicians for early detection, diagnosis, and treatment of corticosteroid-induced osteonecrosis of the femoral head (ONFH) based on a comprehensive analysis of the clinical literature.
Data Sources: For the purpose of collecting potentially eligible articles, we searched for articles in the PubMed, Cochrane Library, Embase, and CNKI databases up to February 2017, using the following key words: "corticosteroid", "osteonecrosis of the femoral head", "risk factors", "diagnosis", "prognosis", and "treatment".
Study Selection: Articles on relationships between corticosteroid and ONFH were selected for this review. Read More
Transfus Apher Sci 2017 10 2;56(5):717-718. Epub 2017 Sep 2.
Department of Hematology, Faculty of Medicine, Baskent University, Ankara, Turkey; Baskent University Adana Adult Bone Marrow Transplantation Center, Yuregir, 01250 Adana, Turkey. Electronic address:
PLoS One 2017 2;12(10):e0185305. Epub 2017 Oct 2.
Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan.
Ocular hypertension (OHT) caused by inflammation or corticosteroid treatment is a common complication of uveitis. Ripasudil hydrochloride hydrate (K-115) is reportedly efficacious for lowering intraocular pressure (IOP). We retrospectively compared the IOP-lowering effect of K-115 for inflammatory and corticosteroid-induced OHT associated with uveitis. Read More
Am J Vet Res 2017 Oct;78(10):1171-1181
OBJECTIVE To assess the discriminatory value for corticosteroid-induced alkaline phosphatase (CiALP) activity and other variables that can be measured routinely on a CBC and biochemical analysis for the diagnosis of hypoadrenocorticism in dogs. SAMPLE Medical records of 57 dogs with confirmed hypoadrenocorticism and 57 control dogs in which hypoadrenocorticism was suspected but ruled out. PROCEDURES A retrospective case-control study was conducted. Read More
J Proteome Res 2017 10 27;16(10):3753-3765. Epub 2017 Sep 27.
Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University , Kowloon, Hong Kong, China.
The molecular pathophysiology of corticosteroid-induced ocular hypertension (CIH) is not well understood. To determine the biological mechanisms of CIH, this study investigated protein expression profiles of human trabecular meshwork (hTM) cells in response to dexamethasone and prednisolone treatment. Both discovery-based sequential windowed data independent acquisition of the total high-resolution mass spectra (SWATH-MS) and targeted based high resolution multiple reaction monitoring (MRM-HR) confirmation were applied using a hybrid quadrupole-time-of-flight mass spectrometer. Read More
Sci Rep 2017 Aug 31;7(1):10180. Epub 2017 Aug 31.
Disciplinary Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, CL, 8380453, Chile.
The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased by corticosteroid treatment; however, the glucocorticoid-mediated molecular regulation remains unknown. Read More
Acta Med Iran 2017 Jun;55(6):375-380
Department of Dermatology, Skin Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Pemphigus vulgaris is a chronic autoimmune disease and glucocorticoids are one of the main treatments. Our study investigates the prevalence and associated factors of glucocorticoid-induced diabetes mellitus in these patients under different glucocorticoid regimens. 36 patients with first diagnosed Pemphigus vulgaris based on pathological and direct immunofluorescence findings who had received different glucocorticoid regimens (1-2 mg/kg oral or 1-2 mg/kg oral with 1g methylprednisolone pulse daily for 3 consecutive days with or without azathioprine) were evaluated during 2014-2016. Read More
Eur Radiol 2018 Jan 19;28(1):410-417. Epub 2017 Jul 19.
Department of Radiology, Paediatric Radiology, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Objectives: Corticosteroid treatment of paediatric leukaemia patients can lead to osteonecrosis (ON). We determined whether bone marrow oedema (BME) is an early sign of progressive ON and eventual bone collapse.
Methods: In a retrospective study, two radiologists reviewed MR imaging characteristics of 47 early stage epiphyseal ON in 15 paediatric and adolescent leukaemia patients. Read More
BMC Ophthalmol 2017 Jun 28;17(1):106. Epub 2017 Jun 28.
Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, People's Republic of China.
Background: Bilateral keratitis rarely occurs in individuals without predisposing factors. Here we describe the clinical course of a patient who developed a bilateral keratitis caused by Morganella. morganii which might be associated with long term using of topical corticosteroids-containing preparations on the face. Read More
Respir Res 2017 06 26;18(1):129. Epub 2017 Jun 26.
Centre for Infection and Immunity, Queen's University of Belfast, Belfast, Northern Ireland, UK.
Background: Treatment of severe asthma may include high dose systemic-steroid therapy which is associated with substantial additional morbidity. This study estimates the additional healthcare costs associated with steroid-induced morbidity by comparing three patients groups: those with severe asthma, moderate asthma and no asthma.
Methods: Patients with severe asthma (n = 808, GINA step 5 treatment) were matched by age and gender with patients with mild/moderate asthma (n = 3,975, GINA step 2 and 3 treatment) and a non-asthma control cohort (with a diagnosis of rhinitis; n = 2,412) from the Optimum Patient Care Research Database (OPCRD), a nationally representative primary care database. Read More
Cytokine 2017 09 28;97:38-41. Epub 2017 May 28.
Viral Immunology Center, Department of Biology, Georgia State University, Atlanta, GA, United States; Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States. Electronic address:
AIDS-related human cytomegalovirus retinitis remains a leading cause of blindness worldwide. We compared two C57BL/6 mouse models of experimental murine cytomegalovirus (MCMV) retinitis for intraocular expression of suppressors of cytokine signaling (SOCS)1 and SOCS3, host proteins that are inducible negative feedback regulators of cytokine signaling. These mouse models differed in method of immune suppression, one by retrovirus-induced immune suppression (MAIDS) and the other by corticosteroid-induced immune suppression. Read More
Ann Allergy Asthma Immunol 2017 05 1;118(5):557-563. Epub 2017 Apr 1.
Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Background: Despite the use of alfacalcidol in the management of corticosteroid-induced osteoporosis, it has never been considered an adjunct treatment for asthma management. It can target vitamin D deficiency, a possible risk factor for asthma, and, hence, improve pulmonary function of patients with asthma.
Objective: To explore the effect of alfacalcidol administration on pulmonary function and study the pattern of vitamin D deficiency in adults with asthma in Egypt. Read More
Eur J Obstet Gynecol Reprod Biol 2017 May 18;212:85-90. Epub 2017 Mar 18.
Frauenklinik und Poliklinik, Technische Universität München, Munich, Germany.
Objective: To analyze the effect of maternal betamethasone given for fetal lung maturation on fetal short-term variation (STV) and average acceleration and deceleration capacity (AAC/ADC). Both of these factors are calculated by phase-rectified signal averaging (PRSA) and represent new parameters to assess the fetal autonomic nervous system.
Study Design: A longitudinal prospective study including 26 pregnant women at risk for preterm delivery was performed. Read More
Can J Physiol Pharmacol 2017 Jun 10;95(6):714-720. Epub 2017 Feb 10.
e Department of Tropical Medicine, Faculty of Medicine, Tanta University, Egypt.
Corticosteroids are used to treat a variety of diseases like bronchial asthma. However, long-term corticosteroids have a gastric ulcerogenic potential. Montelukast (MTK) and Nigella sativa oil (NSO) are used in treatment of bronchial asthma. Read More
Clin Case Rep 2017 Feb 23;5(2):159-163. Epub 2017 Jan 23.
Gastroenterology Service Hepatitis and Liver Transplant Unit IDIBELL Hospital Universitari de Bellvitge Feixa Llarga s/n L'Hospitalet de Llobregat 08907 Barcelona Spain.
Our case report discusses the usefulness of administering romiplostim as a second-line treatment before splenectomy in a cirrhotic patient with immune thrombocytopenia who developed corticosteroid-induced Cushing's syndrome. Corticosteroids were tapered and consequently withdrawn. The patient made a full recovery postsplenectomy. Read More
Curr Treat Options Neurol 2017 Jan;19(1)
The Scheie Eye Institute, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Opinion Statement: Giant cell arteritis (GCA) is a systemic inflammatory vasculitis affecting medium and large vessels with potentially sight and life-threatening complications. Early diagnosis and prompt treatment are imperative in order to prevent vision loss and progression of the disease. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are inflammatory markers which are elevated in the majority of patients and support the diagnosis of GCA among patients who present with typical symptoms. Read More