396,252 results match your criteria Corticosteroid Injections of Joints and Soft Tissues


Early-Stage Translational Research in Perinatal Medicine.

Neonatology 2018 Dec 6;115(2):182-188. Epub 2018 Dec 6.

Liggins Institute, University of Auckland, Auckland, New

Background: Pre-clinical research, which encompasses studies in animals and in the laboratory, has made significant contributions to the improvement of neonatal outcomes.

Methods: Here, we describe examples of how pre-clinical research can be the starting point on the journey to the development of new interventions to improve neonatal care and outcomes and discuss recent progress in ensuring methodological and ethical rigour in pre-clinical research involving animal models.

Results: Studies in pregnant sheep led to the serendipitous discovery that preterm lambs born after exogenous corticosteroid exposure were able to aerate their lungs. Read More

View Article
December 2018
3 Reads

Corticosteroid-dependent tuberculous meningitis: A case report.

J Neurol Sci 2018 Nov 17;396:232-234. Epub 2018 Nov 17.

Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan. Electronic address:

View Article
November 2018
1 Read

Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis.

Cochrane Database Syst Rev 2018 Dec 3;12:CD012620. Epub 2018 Dec 3.

Division of Pulmonary and Critical Care Medicine, University of Missouri, Columbia, MO, USA.

Background: Long-acting bronchodilators such as long-acting β-agonist (LABA), long-acting muscarinic antagonist (LAMA), and LABA/inhaled corticosteroid (ICS) combinations have been used in people with moderate to severe chronic obstructive pulmonary disease (COPD) to control symptoms such as dyspnoea and cough, and prevent exacerbations. A number of LABA/LAMA combinations are now available for clinical use in COPD. However, it is not clear which group of above mentioned inhalers is most effective or if any specific formulation works better than the others within the same group or class. Read More

View Article
December 2018
2 Reads

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome.

Cochrane Database Syst Rev 2018 Dec 2;12:CD011215. Epub 2018 Dec 2.

School of Korean Medicine, Pusan National University, Beom-eu, Meulgeum, Yangsan, Korea, South, 626-870.

Background: Carpal tunnel syndrome (CTS) is a compressive neuropathic disorder at the level of the wrist. Acupuncture and other methods that stimulate acupuncture points, such as electroacupuncture, auricular acupuncture, laser acupuncture, moxibustion, and acupressure, are used in treating CTS. Acupuncture has been recommended as a potentially useful treatment for CTS, but its effectiveness remains uncertain. Read More

View Article
December 2018
3 Reads

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST.

Health Technol Assess 2018 Dec;22(70):1-82

Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.

Background: Asthma exacerbations affect the quality of life of patients with asthma and have a major effect on the overall costs of asthma care. An asthma self-management plan that advises the temporary quadrupling of inhaled corticosteroid dose may prevent asthma exacerbations, but this needs to be confirmed before being adopted widely.

Objectives: To compare the clinical effectiveness and cost-effectiveness of an asthma self-management plan that advises patients to temporarily quadruple the dose of inhaled corticosteroid when asthma control starts to deteriorate with a standard self-management plan. Read More

View Article
December 2018

Preliminary experience of the use of high-resolution skin ultrasound for the evaluation of extrathyroideal manifestations of Graves' disease and response to UVA-1 phototherapy.

Photodermatol Photoimmunol Photomed 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy.

Graves' orbitopathy (GO) and pre-tibial mixedema (PTM) are autoimmune manifestation sharing the same etiology and histopathology, a chronic course and a frustrating treatment. Current management include topical and systemic corticosteroid as first line therapy, whereas cyclosporine, surgery and orbital radiotherapy are indicated for severe GO with variable results and mostly temporary remissions. In particular, keratopath and photophobia, due to exophthalmos and eyelid retraction, impaired eye mobility and diplopia due to the compression of optic nerve and extra-ocular muscles are usually minimally modified, as well as leg plaques/nodules and lymphoedema. Read More

View Article
December 2018
3 Reads

Growth of children with biliary atresia living with native livers: impact of corticoid therapy after portoenterostomy.

Eur J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

Pediatric Liver and Gut Research Group, Children's Hospital, Helsinki University Hospital, Helsinki, Finland.

We addressed growth of biliary atresia (BA) patients living with native livers between ages 0-6 and effects of post-surgical corticosteroid treatment on growth. Growth charts of 28 BA patients born in Finland between 1987 and 2017 were retrospectively evaluated. Dosage and length of corticosteroid treatment and hydrocortisone substitution were reviewed. Read More

View Article
December 2018

Incidence of fatigue and low-dose corticosteroid use in prostate cancer patients receiving systemic treatment: a meta-analysis of randomized controlled trials.

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.

Background: Cancer-related fatigue (CRF) is a complex condition that is reported in > 50% of cancer patients. In men with castration-resistant prostate cancer (CRPC), CRF was reported in 12-21% of patients. Approved systemic therapy against CRPC is commonly administered in combination with androgen-deprivation treatment (ADT) and, in some cases, with daily, low-dose corticosteroids. Read More

View Article
December 2018

Prospective pilot study comparing deep sclerectomy outcomes with a long-term and intense corticosteroid treatment versus a standard one.

BMJ Open Ophthalmol 2018 31;3(1):e000165. Epub 2018 Oct 31.

Glaucoma and Neuro-Ophthalmology Department, FISABIO Oftalmologia, Valencia, Spain.

Objective: To compare prospectively intraocular pressure (IOP) results after deep sclerectomy (DS) using a topical short-term corticosteroid treatment (STCT, 1  month) versus a topical long-term and intense corticosteroid treatment (LTCT, 6 months) in a two2  year-follow-up.

Methods: Patients with medically uncontrolled open angle glaucoma were prospectively recruited and underwent a DS.

Results: We operated 45 eyes of 45 patients, 22 in STCT group and 23 in LTCT group. Read More

View Article
October 2018

A Report of Chronic Intestinal Pseudo-obstruction Related to Systemic Lupus Erythematosus.

Open Med (Wars) 2018 25;13:562-564. Epub 2018 Nov 25.

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

Chronic intestinal pseudo-obstruction (CIPO) is a functional gastrointestinal disorder with symptoms of ileus. CIPO can either be idiopathic or secondary to other diseases such as systemic lupus erythematosus (SLE). SLE is involved in many parts of the gastrointestinal system with variable clinical presentations. Read More

View Article
November 2018
1 Read

Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease.

Case Rep Transplant 2018 4;2018:4539757. Epub 2018 Nov 4.

Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Ruxolitinib is an oral selective Janus-associated kinase 1 (JAK1) and JAK2 inhibitor that was initially approved by the FDA in 2014 for treatment of myelofibrosis. In preclinical and retrospective clinical studies, use of ruxolitinib was shown to reduce graft-versus-host-disease (GVHD) in allograft recipients with moderate/severe corticosteroid-dependent or refractory chronic GVHD. While the exact mechanism for action in GVHD is not yet fully understood, prospective studies are ongoing and some patients are receiving ruxolitinib in the setting of steroid refractory GVHD. Read More

View Article
November 2018

Allergic Contact Dermatitis and Autoeczematization to Proctosedyl® Cream and Proctomyxin® Cream.

Case Rep Dermatol 2018 Sep-Dec;10(3):238-246. Epub 2018 Oct 24.

Department of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.

Proctosedyl® and Proctomyxin® are two commonly prescribed hemorrhoid therapies. Their topical application to the perianal region may be complicated by a local allergic contact dermatitis and subsequent autoeczematization reaction. We present three cases of an autoeczematization (ID) reaction to varying topical allergens found in Proctosedyl®/Proctomyxin®. Read More

View Article
October 2018

Intracranial dural arteriovenous fistula mistaken as cervical transverse myelitis.

Pract Neurol 2018 Dec 5. Epub 2018 Dec 5.

Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK

We describe a man with an intracranial dural arteriovenous fistula that presented as a subacute longitudinally extensive cervical myelopathy. The uncommon location of the fistula and the absence of specific radiological signs resulted in initial misdiagnosis as longitudinally extensive transverse myelitis. Neurologists should have a high index of suspicion for dural arteriovenous fistula in older men, especially those with subacute or chronic symptoms, acellular cerebrospinal fluid and, particularly, if there is neurological deterioration soon after corticosteroid treatment. Read More

View Article
December 2018

How Would You Manage This Patient With Gout?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

Ann Intern Med 2018 Dec;169(11):788-795

Beth Israel Deaconess Medical Center, Boston, Massachusetts (R.B.B., C.C.S., R.H.S., A.T.).

Gout is the most common form of inflammatory arthritis. In 2012, the American College of Rheumatology (ACR) issued a guideline, which was followed in 2017 by one from the American College of Physicians (ACP). The guidelines agree on treating acute gout with a corticosteroid, nonsteroidal anti-inflammatory drug, or colchicine and on not initiating long-term urate-lowering therapy (ULT) for most patients after a first gout attack and in those whose attacks are infrequent (<2 per year). Read More

View Article
December 2018

Inhaled corticosteroids and fractures in chronic obstructive pulmonary disease: current understanding and recommendations.

Curr Opin Pulm Med 2018 Nov 30. Epub 2018 Nov 30.

Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Purpose Of Review: Inhaled corticosteroid (ICS) is commonly used in the management of patients with chronic obstructive pulmonary disease (COPD) for symptom relief and exacerbation prevention; however, there is a growing concern that ICS increases risk of osteoporosis and fractures in patients with COPD.

Recent Findings: Osteoporosis is a major comorbidity of COPD. There is evidence from large observational studies that use of ICS for prolonged period of time (e. Read More

View Article
November 2018

Joint and soft-tissue injections in rehabilitation inpatients taking direct oral anticoagulants.

Int J Rehabil Res 2018 Nov 30. Epub 2018 Nov 30.

Providence Healthcare.

The risk for complications associated with joint and soft-tissue injections in patients taking direct oral anticoagulants (DOACs) is not fully understood. In this retrospective evaluation of 445 inpatients in a rehabilitation hospital who received corticosteroid injections, complications were compared in patients on DOACs with those who were not. After a review of all injections, no adverse events of significant bleeding (intra-articular or extra-articular) were observed. Read More

View Article
November 2018

Atypical calcific tendinitis involving the long biceps tendon: A rare cause of hemiplegic shoulder pain.

J Back Musculoskelet Rehabil 2018 Nov 23. Epub 2018 Nov 23.

Department of Rehabilitation Medicine, Daegu Veterans Health Service Medical Center, Daegu, Korea.

Background And Objective: Calcific tendinitis is commonly found in the rotator cuff; however, it is very rare in the long biceps tendon (LBT). Furthermore, calcific tendinitis involving the LBT in the hemiplegic shoulder after a stroke has not been previously reported.

Materials And Method: We present a case of a 63-year-old man who suffers from a stroke and atypical calcific tendinitis involving the LBT as a rare cause of hemiplegic shoulder pain. Read More

View Article
November 2018
1 Read

Intravitreal Dexamethasone Implant in the Treatment of Non-Infectious Uveitic Macular Edema.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):169-175

Department of Ophthalmology, Dokuz Eylul University, İzmir, Turkey.

Macular Edema (ME) is a common complication, leading to severe vision loss in patients with Non-Infectious Uveitis (NIU). The treatment of uveitic ME is still very challenging for many ophthalmologists. Various agents, such as corticosteroids, anti-vascular endothelial growth factors, and immune-modulators, have been used for combatting uveitic ME. Read More

View Article
January 2018

Knowledge, Attitudes and Behavior Regarding Topical Corticosteroids in a Sample of Pharmacy Students: A Cross Sectional Survey.

Indian Dermatol Online J 2018 Nov-Dec;9(6):432-434

Department of Pharmacy Practice, Al Shifa College of Pharmacy, Perintalmanna, Kerala, India.

Introduction And Background: The abuse and misuse of topical corticosteroids, especially over the face, is an increasing problem encountered by dermatologists in India. Lack of patient awareness and the ease of obtaining topical corticosteroids without a prescription are important underlying factors. As the first point of contact, the pharmacist has an important role in controlling topical corticosteroid abuse. Read More

View Article
December 2018

Resolution of primary ovarian insufficiency after corticosteroid administration in a myasthenia gravis patient: Report and minireview of the literature.

Neurol India 2018 Nov-Dec;66(6):1807-1810

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

View Article
December 2018

Does adjunctive corticosteroid and aspirin therapy improve the outcome of tuberculous meningitis?

Neurol India 2018 Nov-Dec;66(6):1672-1677

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Stroke is common in tuberculous meningitis (TBM), and aspirin has been shown to reduce mortality. A combination of aspirin and corticosteroid may be more useful in this condition.

Aim: To evaluate the effect of aspirin and corticosteroid adjunctive therapy alone or in combination in determining the outcome of TBM. Read More

View Article
December 2018

Surrogate advertisement of a super-potent corticosteroid-containing cream: An alarming development and a cautionary tale of its consequences.

Indian J Dermatol Venereol Leprol 2018 Nov 30. Epub 2018 Nov 30.

Mohana Skin and Hair Clinic, Hyderabad, Telangana, India.

View Article
November 2018

Carcinoid tumors of the thymus and Cushing's syndrome: Clinicopathologic features and current best evidence regarding the cell of origin of these unusual neoplasms.

Ann Diagn Pathol 2018 Nov 22;38:71-79. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

It is uncertain whether thymic neuroendocrine tumors (NET) associated with Cushing's syndrome (CS) produce corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) and whether the thymus contains ACTH and/or CRH cells that could originate NET. The clinicopathologic features of 5 typical (TC) and 6 atypical carcinoids (ATC), 10 additional non-neoplastic thymi, 6 adrenal glands with bilateral nodular hyperplasia and 8 adrenal cortical adenomas were reviewed. Representative slides were immunostained for ACTH and CRH. Read More

View Article
November 2018

Interaction of prednisone with dsDNA at silver nanoparticles/poly(glyoxal-bis(2-hydroxyanil))/dsDNA modified electrode and its analytical application.

Bioelectrochemistry 2018 Nov 16;126:56-63. Epub 2018 Nov 16.

Department of Chemistry, Ankara University, Ankara, Turkey.

This paper reports the fabrication of an electrochemical DNA biosensor for the electrochemical determination of prednisone (PRD), which is a synthetic corticosteroid. For this purpose, silver nanoparticles (AgNPs) and a new polymer film poly(glyoxal-bis(2-hydroxyanil)) (P(GBHA)) were electrochemically deposited on a glassy carbon electrode (GCE), respectively. Then, an electrochemical DNA biosensor was prepared onto this electrode surface (GCE/AgNPs/P(GBHA)) by the immobilization of dsDNA using a chronoamperometry method. Read More

View Article
November 2018

Clinical and biological factors associated with recurrences of severe toxoplasmic retinochoroiditis confirmed by aqueous humor analysis.

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Ophthalmology Department, Reference Center in Rare diseases, DHU ViewRestore, Pitié-Salpêtrière Hospital, Paris VI University, F-75013 Paris, France.

Purpose: To investigate clinical and biological factors influencing recurrences of severe toxoplasmic retinochoroiditis (TRC) confirmed by aqueous humor analysis.

Design: Retrospective case series.

Methods: Retrospective analysis of 87 subjects with severe TRC, proven by positive Goldmann-Witmer coefficient (GWC), Toxoplasma gondii (T. Read More

View Article
November 2018

Treating Infantile Spasms with High-Dose Oral Corticosteroids: A Retrospective Review of 87 Children.

Pediatr Neurol 2018 Oct 3;87:30-35. Epub 2018 Aug 3.

Departments of Neurology and Pediatrics, The Johns Hopkins Hospital, Baltimore, Baltimore, Maryland. Electronic address:

Background: Hormonal therapy is the treatment of choice in most patients with infantile spasms, but the optimal way to provide this therapy is unclear. Intramuscular adrenocorticotropic hormone (ACTH) has historically used first-line; however, there are significant logistical and financial issues. Our institution has used high-dose prednisolone as the first-line hormonal treatment of infantile spasms since 2006 and published our early experience with 15 infants in 2009. Read More

View Article
October 2018

Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

BMC Musculoskelet Disord 2018 Nov 30;19(1):427. Epub 2018 Nov 30.

Federal University of Pelotas - Post-Graduate Program in Epidemiology, Rua Marechal Deodoro, 1160, 3° andar, Pelotas, RS, Zip code: 96020-220, Brazil.

Background: Studies have shown that cytokines play a role in bone remodeling.

Methods: In 1993, all hospital births occurred in Pelotas (Brazil) were identified and a total of 5249 newborns were included in the present cohort. Sub-samples of this cohort were visited during childhood and all members were traced at 11, 15, 18 and 22 years old. Read More

View Article
November 2018

Severe iron-deficiency anemia as initial manifestation of pulmonary hemosiderosis in a child.

Einstein (Sao Paulo) 2018 Nov 29;16(4):eRC4505. Epub 2018 Nov 29.

Serviço de Pediatria Médica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Idiopathic pulmonary hemosiderosis is a potentially fatal disease that results from episodes of alveolar hemorrhage of unknown origin. The clinical spectrum is varied, and anemia may constitute the only manifestation of illness, preceding other signs and symptoms by several months. We present the case of a 4 year-old child presenting with fever, vomiting and prostration, associated with pallor. Read More

View Article
November 2018
1 Read

Treatment for patients with recurrent fetal losses positive for anti-cardiolipin beta2 glycoprotein I antibody using Sairei-to (Chai-ling-tang) and low-dose aspirin.

J Obstet Gynaecol Res 2018 Dec 4. Epub 2018 Dec 4.

General Center for Perinatal, Maternal and Neonatal Medicine, Niigata University Medical and Dental Hospital, Niigata City, Japan.

Aim: Recently, it is widely recognized that positivity for anti-phospholipid antibodies is a causative factor for a range of reproductive failures. Anti-cardiolipin beta2 glycoprotein I antibody (anti-CL-beta2-GPI) is a representative anti-phospholipid antibody, which strongly correlates with the development of thrombotic events and diversity of adverse pregnancies. In this series, we aimed to elucidate effective treatment for patients with recurrent fetal losses positive for anti-CL-beta2-GPI using Japanese-modified Chinese herbal medicine. Read More

View Article
December 2018
1 Read

Protective parents and permissive children: what qualitative interviews with parents and children can tell us about the feasibility of juvenile idiopathic arthritis trials.

Pediatr Rheumatol Online J 2018 Dec 4;16(1):76. Epub 2018 Dec 4.

Department of Psychological Sciences, University of Liverpool, Whelan Building, Brownlow Hill, Liverpool, L69 3GB, UK.

Background: Patient recruitment can be very challenging in paediatric studies, especially in relatively uncommon conditions, such as juvenile idiopathic arthritis (JIA). However, involving children and young people (CYP) in the design of such trials could promise a more rapid trajectory towards making evidence-based treatments available. Studies involving CYP are advocated in the literature but we are not aware of any early stage feasibility studies that have qualitatively accessed the perspectives of parents and CYP with a long term condition to inform design and conduct of a trial. Read More

View Article
December 2018

Carnosic acid, Tangeretin, and Ginkgolide-B Anti-Neoplastic Cytotoxicity in Dual Combination with Dexamethasone-[anti-EGFR] in Pulmonary Adenocarcinoma (A549).

Anticancer Agents Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Department of Basic Sciences, College of Veterinary Medicine at Wise Center, Mississippi State University, Mississippi State, Mississippi 39762. United States.

Background - Traditional chemotherapeutics of low-molecular weight diffuse passively across intact membrane structures of normal healthy cells found in tissues and organ systems in a non-specific unrestricted manner which largely accounts for the induction of most sequelae which restrict dosage, administration frequency, and duration of therapeutic intervention. Molecular strategies that offer enhanced levels of potency, greater efficacy and broader margins-of-safety include the discovery of alternative candidate therapeutics and development of methodologies capable of mediating properties of selective "targeted" delivery. Materials-and-Methods - The covalent immunopharmaceutical, dexamethasone-(C21-phosphoramidate)-[anti-EGFR] was synthesized utilizing organic chemistry reactions that comprised a multi-stage synthesis regimen. Read More

View Article
December 2018
2 Reads

Bullous pemphigoid, a dermatosis of the elderly

Rev Prat 2017 12;67(10):1080-1083

Département de dermatologie, centre hospitalier universitaire de Rouen ; Inserm U1234, Institut de recherche et d'innovation biomédicale, université de Rouen, Rouen, France.

Bullous pemphigoid, a dermatosis of the elderly. Bullous pemphigoid is the most common autoimmune bullous disease and affects almost exclusively the elderly. Its occurrence is related to the presence of pathogenic autoantibodies directed against structural proteins (BP180 and BP230) of the protein adhesion complex of the dermo-epidermal junction: the hemi-desmosome. Read More

View Article
December 2017
3 Reads

Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: case report and literature review.

Cardiol Young 2018 Dec 4:1-3. Epub 2018 Dec 4.

3Pediatric Nephrology Department,Puerta del Mar University Hospital,Cadiz,Spain.

In approximately 5% of patients with idiopathic recurrent pericarditis, the disease usually follows a chronic relapsing course, and children can develop dependence and side effects of prolonged high-dose corticosteroid regimens. In this setting anakinra, a recombinant human interleukin-1 competitive receptor antagonist that blocks the biologic effects of interleukin-1, thereby reducing systemic inflammatory responses, appears to be one of the most promising strategies. We report an adolescent with steroid-dependent idiopathic recurrent pericarditis that was successfully treated with anakinra, highlighting that this therapeutic option seems to be an effective, rapidly acting, steroid-sparing, and relatively safe agent for the treatment of this entity in children. Read More

View Article
December 2018

Simultaneous Bilateral Optic Neuritis Following Human Papillomavirus Vaccination in a Young Child.

Cureus 2018 Sep 24;10(9):e3352. Epub 2018 Sep 24.

Ophthalmology, School of Medical Sciences/Universiti Sains Malaysia, Kelantan, MYS.

Vaccination-induced optic neuritis is not common. The development of optic neuritis following various vaccinations have been reported, suggesting a possible association between optic neuritis and vaccination. Of those reported cases, influenza vaccines have been the most common. Read More

View Article
September 2018

Incidence and risk factors for potentially suboptimal serum concentrations of vancomycin during cardiac surgery.

World J Cardiol 2018 Nov;10(11):234-241

Cardiovascular Surgery, Department of Surgical Sciences, Molinette Hospital, University of Turin, Turin 10126, Italy.

Aim: To investigate the incidence and risk factors for vancomycin concentrations less than 10 mg/L during cardiac surgery.

Methods: In this prospective study, patients undergoing cardiac surgery received a single dose of 1000 mg of vancomycin. Multiple arterial samples were drawn during surgery. Read More

View Article
November 2018
1 Read

Cost-effectiveness of umeclidinium as add-on to ICS/LABA therapy in COPD: A UK perspective.

Respir Med 2018 Dec 24;145:130-137. Epub 2018 Oct 24.

Value Evidence & Outcomes, GSK, Research Triangle Park, NC, USA; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. Electronic address:

Introduction: The cost-effectiveness of long-acting muscarinic antagonist (LAMA) umeclidinium bromide (UMEC) 62.5 μg as add-on therapy to other maintenance COPD treatments is unknown.

Methods: This analysis assessed the cost-effectiveness of the following in COPD: UMEC + fluticasone furoate/vilanterol 100/25 μg (FF/VI); UMEC + fluticasone propionate/salmeterol 250/50 μg (FP/SAL); and UMEC + several alternative choices of inhaled corticosteroid/long-acting β-agonist (ICS/LABA). Read More

View Article
December 2018

'Real-life' experience in asthmatic children treated with omalizumab up to six-years follow-up.

Allergol Immunopathol (Madr) 2018 Nov 30. Epub 2018 Nov 30.

Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain.

Introduction And Objectives: Omalizumab is present in international guidelines for the control of severe asthma, but data on the long-term effects in children are limited. Our objective was to perform a 'real-life' long-term trial of omalizumab in children with allergic asthma.

Materials And Methods: An observational single center 'real-life' study was performed. Read More

View Article
November 2018

Short-term dexamethasone treatment transiently, but not permanently, attenuates fibrosis after acute-to-chronic kidney injury.

BMC Nephrol 2018 Dec 3;19(1):343. Epub 2018 Dec 3.

Laboratory of Pathophysiology, University of Antwerp, 2160, Antwerpen, Belgium.

Background: Acute kidney injury (AKI) is an underestimated, yet important, risk factor for the development of chronic kidney disease (CKD). Persistence of inflammation after a renal ischemic injury has been observed, both in experimental models and patients, and is thought to be an important mechanisms underlying progression of acute-to-chronic renal injury. Temporary suppression of inflammation immediately after AKI might therefore be a good first-line therapeutic strategy towards a better long term outcome. Read More

View Article
December 2018
1 Read

Diagnosis and Management of Hip Abductor Insufficiency.

R I Med J (2013) 2018 Dec 3;101(10):46-50. Epub 2018 Dec 3.

Division of Sports Medicine, Department of Orthopaedic Surgery, Warren Alpert Medical School, Brown University.

Greater Trochanteric Pain Syndrome (GTPS) is a common cause of lateral hip pain, with an incidence of 1.8 per 1000 patients, most commonly occurring between the fourth and sixth decades of life. When GTPS fails to improve with conservative management, hip abductor insufficiency should be suspected. Read More

View Article
December 2018

Noradrenergic and corticosteroid receptors regulate somatic and motivational symptoms of morphine withdrawal.

Behav Brain Res 2018 Nov 27. Epub 2018 Nov 27.

Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland.

Somatic and motivational symptoms accompanying opiate withdrawal are considered one of the major reasons for relapse to opiate-seeking and opiate-taking behaviors. These symptoms are accompanied by the activation of stress-related processes including hypothalamic-pituitary-adrenal axis activity and noradrenergic (NA) signaling. In particular, the NA system plays an important role in the expression of somatic signs of opiate withdrawal, whereas glucocorticoid (GR) and mineralocorticoid receptors (MR) are activated during opiate abstinence. Read More

View Article
November 2018

Acetarsol in the management of mesalazine-refractory ulcerative proctitis: a tertiary-level care experience.

Eur J Gastroenterol Hepatol 2018 Nov 29. Epub 2018 Nov 29.

Nottingham Digestive Diseases Centre.

Background: Mesalazine-refractory ulcerative proctitis is common, with a significant proportion of the patients requiring escalation to immunomodulators or biological therapy. Three small preliminary cohort studies suggested good clinical efficacy for the organic arsenic derivative acetarsol in the management of proctitis. Our aim was to describe our experience on the use of acetarsol in proctitis and to review all existing evidence on its safety and efficacy. Read More

View Article
November 2018
1 Read

Neurodevelopmental outcomes of extremely preterm infants in New South Wales and the Australian Capital Territory.

J Paediatr Child Health 2018 Nov 30. Epub 2018 Nov 30.

Department of Newborn Care, Royal Hospital for Women, Sydney, New South Wales, Australia.

Aim: This study aimed to provide updated information on gestation-specific neurodevelopmental outcomes of extremely to very preterm infants 23-28 weeks' gestation admitted to neonatal intensive care units (NICUs).

Methods: This was a population-based retrospective cohort study of infants born between 23 and 28 weeks' gestation and admitted to a network of NICUs between 2007 and 2012 in a well-defined geographic area of New South Wales (NSW) and the Australian Capital Territory (ACT). Primary outcome was moderate to severe neurodevelopmental impairment. Read More

View Article
November 2018

Changes in the clinical and histological characteristics of Chinese chronic rhinosinusitis with nasal polyps over 11 years.

Int Forum Allergy Rhinol 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Background: Traditionally, it was believed that chronic rhinosinusitis with nasal polyps (CRSwNP) demonstrated less eosinophilic and more neutrophilic inflammation in China compared to North America and Europe. However, inflammatory patterns may change over time. The study aimed to analyze the changing trends in the clinical and histological characteristics of CRSwNP over time in China. Read More

View Article
November 2018

Inhaled corticosteroids might not increase the risk of pneumonia in patients with chronic obstructive pulmonary disease in Japan.

Int J Chron Obstruct Pulmon Dis 2018 23;13:3503-3509. Epub 2018 Oct 23.

Department of Respiratory Medicine, Fukuoka University Hospital, Nanakuma, Jonanku, Fukuoka, Japan,

Background: The use of inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD) decreases the frequency of COPD exacerbations. Recently, pneumonia was reported as a complication of ICS in patients with COPD. However, there have been few reports concerning the relationship between ICS and pneumonia in Japan. Read More

View Article
October 2018
2 Reads

Efficacy and safety of mycophenolate mofetil versus levamisole in frequently relapsing nephrotic syndrome: an open-label randomized controlled trial.

Kidney Int 2018 Nov 22. Epub 2018 Nov 22.

Division of Nephrology, Department of Pediatrics, Indian Council of Medical Research Advanced Center for Research in Nephrology, India Institute of Medical Sciences, New Delhi, India. Electronic address:

Both levamisole and mycophenolate mofetil (MMF) prevent relapses in patients with frequently relapsing nephrotic syndrome; however, their efficacy has not been compared prospectively. This single-center, randomized, open-label trial enrolled 149 children ages 6-18 years with frequently relapsing or steroid-dependent nephrotic syndrome. Participants were randomized in a 1:1 ratio to receive therapy with MMF (750-1000 mg/m daily) or levamisole (2-2. Read More

View Article
November 2018
1 Read

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy.

Invest Ophthalmol Vis Sci 2018 Nov;59(13):5682-5692

Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands.

Purpose: To isolate, culture, and characterize primary human choroidal endothelial cells, and to assess their responsiveness to corticosteroids, in order to enable knowledge gain on the pathogenesis of central serous chorioretinopathy.

Methods: Choroidal endothelial cells were isolated from cadaveric human donors. Magnetic-activated cell sorting with anti-human CD31 was performed for choroidal endothelial cell isolation. Read More

View Article
November 2018
2 Reads

Early postoperative intraocular pressure elevation following cataract surgery.

Curr Opin Ophthalmol 2019 Jan;30(1):56-62

Private Practice, Gdańsk, Poland.

Purpose Of Review: The aim of this review was to assess the risk factors and course of postoperative intraocular pressure (IOP) increase in order to determine the optimal the treatment.

Recent Findings: Early postoperative IOP elevation following cataract surgery is a frequent adverse event, and might represent 88% early postoperative complications. The risk factors for IOP elevation following phacoemulsification cataract surgery include residual viscoelastic material, resident performed surgery, glaucoma, pseudoexfoliation syndrome, axial length over 25 mm, tamsulosin intake, topical steroid application in steroid responders. Read More

View Article
January 2019
1 Read

Determinants of survival in lung transplantation patients with idiopathic pulmonary fibrosis: a retrospective cohort study.

Transpl Int 2018 Nov 28. Epub 2018 Nov 28.

Dept. of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.

Survival after lung transplantation (LTx) for idiopathic pulmonary fibrosis (IPF) is worse compared to other indications for LTx. We investigated the effect of several pre-transplant variables including the use of pre-transplant corticosteroids (CS) on post-transplant graft and CLAD (chronic lung allograft dysfunction) free survival and functional testing (maximum inspiratory and expiratory pressure, six-minute walk test, quadriceps and hand pinch force) in a small cohort of IPF patients. We retrospectively compared 2 groups of IPF patients (n=36 on CS vs. Read More

View Article
November 2018

Patient-reported outcomes and safety in patients undergoing synovial biopsy: comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe.

RMD Open 2018 26;4(2):e000799. Epub 2018 Oct 26.

Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, UK.

Background: We present a European multicenter study, comparing safety data and patient-reported outcomes (PRO) from patients undergoing synovial biopsy using ultrasound-guided needle biopsy (US-NB), ultrasound-guided portal and forceps (US-P&F) or arthroscopic-guided (AG) procedures.

Objectives: To describe safety and PRO data on joint indices of pain, stiffness and swelling before and after biopsy, procedural discomfort, joint status compared with before biopsy and willingness to undergo a second biopsy for each technique and compare the three techniques. To evaluate the impact on PRO and safety data of corticosteroid therapy as part of the biopsy procedure and sequential biopsy procedures. Read More

View Article
October 2018
1 Read