84,964 results match your criteria Corpus Luteum Rupture


Uterine contractility changes in a perfused swine uterus model induced by local anesthetics procaine, lidocaine, and ropivacaine.

PLoS One 2018 6;13(12):e0206053. Epub 2018 Dec 6.

Department of Gynecological Endocrinology and Fertility Disorders, University of Heidelberg, Heidelberg, Germany.

Background: Local anesthetics (LAs) are increasingly used as therapeutics due to their multiple molecular effects. They may be potential agents also in gynecology and reproductive medicine. The objective of this study was to investigate the contractility response of the perfused swine uterus to different concentrations of the LAs procaine, lidocaine, and ropivacaine. Read More

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December 2018

Identification of uterine telocytes and their architecture in leiomyoma.

Folia Med Cracov 2018 ;58(3):89-102

Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland.

Introduction: Uterine leiomyoma is the most widespread benign tumor affecting women of childbearing age. ere are still gaps in the understanding of its pathogenesiss. Telocytes are unique cells described in greater than 50 different locations inside the human body. Read More

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January 2018
1 Read

Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated IVF cycles.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

Graduate School of Health Sciences, Koc University, Davutpasa, Topkapi, Istanbul, Turkey.

Study Question: Are there any differences in the molecular characteristics of the luteal granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that may help explain the defective luteal phase in the former?

Summary Answer: Luteal GC of stimulated IVF cycles, particularly those of agonist-triggered antagonist cycles, are less viable ex vivo, express LH receptor and anti-apoptotic genes at lower levels, undergo apoptosis earlier and fail to maintain their estradiol (E2) and progesterone (P4) production in comparison to natural cycle GC.

What Is Known Already: Luteal function is defective in stimulated IVF cycles, which necessitates P4 and/or hCG administration (known as luteal phase support) in order to improve clinical pregnancy rates and prevent miscarriage. The luteal phase becomes shorter and menstruation begins earlier than a natural cycle if a pregnancy cannot be achieved, indicative of early demise of corpus luteum (premature luteolysis). Read More

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December 2018

Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT3 driver mutations.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

Murdoch Childrens Research Institute, Australia.

Expression of the cytokine IL-11 is elevated in human Helicobacter pylori infection and progressively increases with worsening gastric pathology. Additionally, IL-11 is required for tumour development in STAT3 dependent murine models of gastric cancer (GC) and, when administered acutely, causes resolving atrophic gastritis. However, it is unclear whether locally elevated IL-11 ligand expression can, in isolation from oncogenic gp130-JAK-STAT pathway mutations, initiate GC pathogenesis. Read More

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December 2018

Interhemispheric anatomical disconnection in disorders of consciousness patients.

J Neurotrauma 2018 Dec 6. Epub 2018 Dec 6.

Fondazione IRCCS Istituto Neurologico "Carlo Besta", Neuroradiology department, Milano, Italy ;

In disorder of consciousness (DOC) patients, corpus callosum (CC) and subcortical white matter (SWM) integrity were showed to discriminate between diagnostic categories. The aims of the study were: 1) to clarify the link between the integrity of CC and of SWM and the clinical status in DOC patients, disentangling the role played by the different brain injuries (traumatic or hemorrhagic brain injury); 2) to investigate the relationship between the CC integrity and the brain metabolism. We assessed the diagnostic accuracy of the CC and SWM integrity, using diffusion tensor imaging (DTI) and structural magnetic resonance imaging (sMRI), in a sample of DOC individuals, well-balanced for diagnosis and etiology. Read More

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December 2018
2 Reads

Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function.

Hum Mutat 2018 Dec 6. Epub 2018 Dec 6.

Genome Research Division, Human Genetics department, Radboud University Medical Center Nijmegen and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

Next-generation sequencing has been instrumental in solving the genetic basis of rare inherited diseases, especially neurodevelopmental syndromes. However, functional workup is essential for precise phenotype definition and to understand the underlying disease mechanisms. Using whole exome and whole genome sequencing in 4 independent families with hypotonia, neurodevelopmental delay, facial dysmorphism, loss of white matter and thinning of the corpus callosum, we identified 4 previously unreported homozygous truncating PPP1R21 alleles: c. Read More

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December 2018

Follicular Development and Reproductive Characteristics in Four Species of Brazilian Tropidurus Lizards.

Zoolog Sci 2018 Dec;35(6):553-563

4 Biology Institute, State University of Campinas. Monteiro Lobato st., 255 - Cidade Universitária, Campinas, São Paulo 13083-862, Brazil.

The follicular development and reproductive characteristics of four species of oviparous lizards in the Tropidurus torquatus group were anatomically and histologically evaluated. We measured specimens, recorded the number of follicles and eggs, and removed the right ovary of each individual, which we processed according to histological routine and photo-documented. For all species, ovaries were divided into a cortical germinal bed, where oogonia and stage I oocytes are located, and a medullar stroma, where the remaining follicular developmental stages occur. Read More

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December 2018

Inter-Vendor Reproducibility of Myelin Water Imaging Using a 3D Gradient and Spin Echo Sequence.

Front Neurosci 2018 21;12:854. Epub 2018 Nov 21.

Department of Medicine, The University of British Columbia, Vancouver, BC, Canada.

Myelin water imaging can be achieved using multicomponent T relaxation analysis to quantify measurement of myelin content, termed the myelin water fraction (MWF). Therefore, myelin water imaging can be a valuable tool to better understand the underlying white matter pathology in demyelinating diseases, such as multiple sclerosis. To apply myelin water imaging in multisite studies and clinical applications, it must be acquired in a clinically feasible scan time (less than 15 min) and be reproducible across sites and scanner vendors. Read More

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November 2018
4 Reads

Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure.

J Neuroinflammation 2018 Dec 5;15(1):336. Epub 2018 Dec 5.

Department of Paediatrics, Sainte-Justine Hospital Research Center, Université de Montréal, Montreal, H3T 1C5, QC, Canada.

Background: The extension of sepsis encompassing the preterm newborn's brain is often overlooked due to technical challenges in this highly vulnerable population, yet it leads to substantial long-term neurodevelopmental disabilities. In this study, we demonstrate how neonatal neuroinflammation following postnatal E. coli lipopolysaccharide (LPS) exposure in rat pups results in persistent reduction in sialylation of cerebral glycoproteins. Read More

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December 2018

Interleukin 1 Upregulates MicroRNA 135b to Promote Inflammation-associated Gastric Carcinogenesis in Mice.

Gastroenterology 2018 Nov 30. Epub 2018 Nov 30.

Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan; AMED-CREST, AMED, Japan Agency for Medical Research and Development, Tokyo, Japan; WPI Nano-Life Science Institute (Nano-LSI), Kanazawa University, Kanazawa, Japan. Electronic address:

Background & Aims: Gastritis is associated with development of stomach cancer, but little is known about changes in microRNA expression patterns during gastric inflammation. Specific changes in gene expression in epithelial cells are difficult to monitor due to the heterogeneity of the tissue. We investigated epithelial cell-specific changes in microRNA expression during gastric inflammation and gastritis-associated carcinogenesis in mice. Read More

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November 2018
1 Read

Pregnancy And Neonatal Diabetes Outcomes in Remote Australia: the PANDORA study-an observational birth cohort.

Int J Epidemiol 2018 Nov 30. Epub 2018 Nov 30.

Clinical and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia.

Background: In Australia's Northern Territory, 33% of babies are born to Indigenous mothers, who experience high rates of hyperglycemia in pregnancy. We aimed to determine the extent to which pregnancy outcomes for Indigenous Australian women are explained by relative frequencies of diabetes type [type 2 diabetes (T2DM) and gestational diabetes (GDM)].

Methods: This prospective birth cohort study examined participants recruited from a hyperglycemia in pregnancy register. Read More

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November 2018

Longitudinal multimodal MRI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia.

Brain 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.

Developing and validating sensitive biomarkers for the presymptomatic stage of familial frontotemporal dementia is an important step in early diagnosis and for the design of future therapeutic trials. In the longitudinal Frontotemporal Dementia Risk Cohort, presymptomatic mutation carriers and non-carriers from families with familial frontotemporal dementia due to microtubule-associated protein tau (MAPT) and progranulin (GRN) mutations underwent a clinical assessment and multimodal MRI at baseline, 2-, and 4-year follow-up. Of the cohort of 73 participants, eight mutation carriers (three GRN, five MAPT) developed clinical features of frontotemporal dementia ('converters'). Read More

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November 2018

17 β-Estradiol Oxidative Stress Attenuation and Autophagy-Induced Dopaminergic Neuroprotection.

Cell J 2019 Apr 18;21(1):1-6. Epub 2018 Nov 18.

Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Objective: Degeneration of dopaminergic neurons in the substantia nigra of the brain stem is the main pathological aspect of Parkinson's disease (PD). 17 β-estradiol (E2) has neuroprotective effects on substantia nigra, however, the underlined mechanism is not well-known. In this study, we evaluated the neuroprotective effects of E2 in the ovariectomized 6-hydroxydopamine- (6-OHDA) rat model of PD. Read More

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Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.

Glia 2018 Dec 2. Epub 2018 Dec 2.

Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia.

The identification of factors that regulate myelination provides important insight into the molecular mechanisms that coordinate nervous system development and myelin regeneration after injury. In this study, we investigated the role of amyloid precursor protein (APP) and its paralogue amyloid precursor-like protein 2 (APLP2) in myelination using APP and APLP2 knockout (KO) mice. Given that BACE1 regulates myelination and myelin sheath thickness in both the peripheral and central nervous systems, we sought to determine if APP and APLP2, as alternate BACE1 substrates, also modulate myelination, and therefore provide a better understanding of the events regulating axonal myelination. Read More

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December 2018

In situ localization of vasotocin receptor gene transcripts in the brain-pituitary-gonadal axis of the catfish Heteropneustes fossilis: a morpho-functional study.

Fish Physiol Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Biotechnology, Cochin University of Science and Technology, Kochi, 682022, India.

In the catfish Heteropneustes fossilis, three vasotocin (VT) receptor subtype genes, v1a1, v1a2, and v2a, were cloned and characterized previously. In the present study, using RNA probes, we localized the distribution of the gene transcripts in the brain-pituitary-gonadal (BPG) axis. The V1a-type receptor, v1a1 and v1a2, genes showed similar and overlapping distribution in the brain. Read More

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December 2018

Qualitative and Quantitative DNA- and RNA-Based Analysis of the Bacterial Stomach Microbiota in Humans, Mice, and Gerbils.

mSystems 2018 Nov-Dec;3(6). Epub 2018 Nov 20.

Universität Hohenheim, Stuttgart, Germany.

Clinical interventions in the stomach have been linked to fecal microbiota alterations, suggesting a function of the stomach in gastrointestinal (GI) homeostasis. We sought to determine the taxonomic bacterial biogeography of the upper GI tract, including different sites within the human stomach (cardia, corpus, and antrum), adjacent upstream (esophagus) and downstream (duodenum) locations, and luminal contents (aspirate), as well as whole-stomach samples from mice and gerbils. Qualitative and quantitative DNA- and RNA-based taxonomic microbiota analyses were combined to study the relationship of relative and absolute bacterial abundances and transcriptionally active bacterial microbiota components in the stomach of humans and mice. Read More

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November 2018

A Case of Seizure Revealing Fahr's Syndrome with Primary Hypoparathyroidism.

Am J Case Rep 2018 Dec 1;19:1430-1433. Epub 2018 Dec 1.

Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND Idiopathic basal ganglia calcification, also known as Fahr's disease or Fahr's syndrome, is a rare neurological disorder characterized by abnormal calcified deposits in the basal ganglia. Here, we report a case of Fahr's syndrome with calcification of the basal ganglia due to hypoparathyroidism in a patient with seizures. CASE REPORT A 52-year-old male patient visited our clinic with seizures. Read More

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December 2018

Microbial organic matter degradation potential in Baltic Sea sediments influenced by depositional conditions and in situ geochemistry.

Appl Environ Microbiol 2018 Nov 30. Epub 2018 Nov 30.

Dept of Life Sciences, Texas A&M University Corpus Christi, Corpus Christi, TX, USA

Globally, marine sediments are a vast repository of organic matter which is degraded through various microbial pathways, including polymer hydrolysis and monomer fermentation. The sources, abundances, and quality (i.e. Read More

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November 2018

Variability of spatiotemporal gait parameters in children with and without Down syndrome during treadmill walking.

Gait Posture 2018 Nov 27;68:207-212. Epub 2018 Nov 27.

Department of Kinesiology and Health, Georgia State University, Atlanta, GA, USA; Center for Movement & Rehabilitation Research, Georgia State University, Atlanta, GA, USA. Electronic address:

Background: Increasing walking speed and including bilateral external ankle load have been shown to improve aspects of the gait pattern of children with Down syndrome (DS). However, it is unknown if speed and ankle load improves the cycle-to-cycle variability in a similar way.

Research Question: How do changes of walking speed and external ankle load impact spatiotemporal variability during treadmill walking in children with and without DS?

Methods: Thirteen children with DS (aged 7-10 years) and thirteen age- and sex-matched typically developing (TD) children participated in this study. Read More

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November 2018

Heterozygosity for Nuclear Factor One X in mice models features of Malan syndrome.

EBioMedicine 2018 Nov 29. Epub 2018 Nov 29.

The School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia; The Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

Background: Nuclear Factor One X (NFIX) haploinsufficiency in humans results in Malan syndrome, a disorder characterized by overgrowth, macrocephaly and intellectual disability. Although clinical assessments have determined the underlying symptomology of Malan syndrome, the fundamental mechanisms contributing to the enlarged head circumference and intellectual disability in these patients remains undefined.

Methods: Here, we used Nfix heterozygous mice as a model to investigate these aspects of Malan syndrome. Read More

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November 2018

Reduced white matter fractional anisotropy mediates cortical thickening in adults born preterm with very low birthweight.

Neuroimage 2018 Nov 28. Epub 2018 Nov 28.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Pediatrics, Sørlandet Hospital, Arendal, Norway.

Development of the cerebral cortex may be affected by aberrant white matter development. Preterm birth with very low birth weight (VLBW) has been associated with reduced fractional anisotropy of white matter and changes in cortical thickness and surface area. We use a new methodological approach to combine white and gray matter data and test the hypothesis that white matter injury is primary, and acts as a mediating factor for concomitant gray matter aberrations, in the developing VLBW brain. Read More

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November 2018

Mathematical model to study the aging of the human follicle according to the telomerase activity.

J Theor Biol 2018 Nov 28. Epub 2018 Nov 28.

IVIRMA, Madrid. Av del Talgo, Madrid, 68. 28023, Spain; IdiPaz, Calle de Pedro Rico, Madrid, 6. 28029, Spain; Rey Juan Carlos University, Madrid, Spain. Electronic address:

The aim of this work is to study the aging rate at which human follicles reach the preovulatory state. To this end, both telomere length and telomerase activity effects on granulosa cells (GCs) aging has been studied. GCs are somatic cells which determine the development of the oocyte. Read More

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November 2018

Corpus cavernosum thrombosis: The membrane may play its role.

Rev Int Androl 2018 Nov 27. Epub 2018 Nov 27.

Radiology Department, Hospital Clínico Universitario de Santiago de Compostela, Spain.

Partial thrombosis of corpus cavernosum is an uncommon condition that needs a high level of suspicious to be diagnosed. Imaging techniques may be very useful, and MR is the state-of-the-art technique. We present a case of a young male who presented to the emergency department with perineal and painful mass. Read More

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November 2018

Schizencephaly: A Review of 734 Patients.

Pediatr Neurol 2018 Oct 8;87:23-29. Epub 2018 Aug 8.

Pediatric Oncology Institute/GRAACC, Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Schizencephaly is a rare congenital cerebral malformation associated with serious neurological manifestations. The number of studies regarding schizencephaly is limited.

Methods: We conducted a literature review and extracted data from the case reports. Read More

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October 2018

Prevalence of aspirin resistance by thromboelastography plus platelet mapping in children with CHD: a single-centre experience.

Cardiol Young 2018 Dec 3:1-6. Epub 2018 Dec 3.

4Department of Pediatric Cardiology,Driscoll Children's Hospital,Corpus Christi,TX,USA.

RationaleAspirin resistance has been reported in up to 80% of children with cardiovascular defects undergoing surgery. Because of a patient who had embolic stroke while on therapeutic aspirin dose but in whom aspirin resistance was present on his thromboelastography platelet mapping, we chose to obtain thromboelastography platelet mapping on cardiac patients on aspirin to assess their risk. OBJECTIVES: This study evaluates aspirin resistance noted in these patients and their characteristics. Read More

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December 2018

Defining Changes in the Spatial Distribution and Composition of Brain Lipids in the Shiverer and Cuprizone Mouse Models of Myelin Disease.

J Histochem Cytochem 2018 Nov 30:22155418815860. Epub 2018 Nov 30.

Biogen, Cambridge, Massachusetts.

Myelin is composed primarily of lipids and diseases affecting myelin are associated with alterations in its lipid composition. However, correlation of the spatial (in situ) distribution of lipids with the disease-associated compositional and morphological changes is not well defined. Herein we applied high resolution matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS), immunohistochemistry (IHC), and liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) to evaluate brain lipid alterations in the dysmyelinating shiverer (Shi) mouse and cuprizone (Cz) mouse model of reversible demyelination. Read More

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November 2018

[The production of the fetus as a "subject of rights": qualitative analysis of medical-Catholic discourses in Chile].

Salud Colect 2018 Jul-Sep;14(3):391-403

Psicólogo. Asistente de investigación y publicaciones, Centro de Desarrollo Cognitivo, Universidad Diego Portales, Santiago, Chile.

This article presents the results of a study aimed at identifying and analyzing the discursive construction of the fetus as a subject of rights on the part of medical-religious institutions in the discussion of the decriminalization of abortion due to three causes in Chile during the 2013-2016 period. To this end, a triangulation was carried out based on an analysis of thematic content and an analysis of certain discursive strategies from the critical discourse analysis perspective using a textual corpus composed of 16 documents. Four analytical themes were identified: factual construction, female pastoral power, biopolitical management of the female body, and intervention technologies. Read More

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May 2018
2 Reads

Idea density in Japanese for the early detection of dementia based on narrative speech.

PLoS One 2018 5;13(12):e0208418. Epub 2018 Dec 5.

Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama, Ikoma City, 630-0192, Japan.

Background: Idea density (ID), a natural language processing-based index, was developed to aid in the detection of dementia through the analysis of English narratives. However, it has not been applied to non-English languages due to the difficulties in translating grammatical concepts. In this study, we defined rules to count ideas in Japanese narratives based on a previous study and proposed a novel method to estimate ID in Japanese text using machine translation. Read More

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December 2018
1 Read

Wilms Tumor of the Ovary: Review of the Literature and Report of 2 Cases.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Primary extrarenal Wilms tumor of the gynecologic tract is extremely rare with scattered case reports occurring in the ovary, uterine corpus and cervix. Only 9 cases of primary ovarian Wilms tumor have been reported to date. Here, we provide an extensive literature review and describe 2 patients with ovarian Wilms tumor: a 36-yr-old female (patient 1) and a 16-yr-old female (patient 2), both presenting with abdominal pain and suspected ovarian torsion. Read More

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December 2018
1 Read

Treatment with vacuum-assisted closure system: A case of anastomotic leak after upper gastrointestinal surgery.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):601-603

Department of General Surgery, University of Health Sciences, Okmeydanı Training and Research Hospital, İstanbul-Turkey.

Presently described is a case treated via stent and vacuum-assisted closure (VAC). The patient developed an oesophagojejunostomy leak (OL) on the ninth postoperative day after a radical total gastrectomy. The patient was a 55-year-old male patient with adenocarcinoma localized to the small curvature on the corpus of the stomach. Read More

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November 2018
1 Read

The GnRH analogue dephereline given in a fixed-time AI protocol improves ovulation and embryo survival in dairy cows.

Res Vet Sci 2018 Nov 28;122:170-174. Epub 2018 Nov 28.

Agrotecnio Center, University of Lleida, Lleida, Spain; Transfer in Bovine Reproduction SLu, Barbastro, Spain. Electronic address:

This study compares the fertility effects of inducing ovulation using the GnRH analogue, dephereline, versus natural GnRH at the end of a 5-day progesterone(P4)-based protocol for fixed-time artificial insemination (FTAI) in in heat-stressed and non-heat stressed lactating dairy cows. Cows were given GnRH (GnRH group, n = 369) or dephereline (DEPH group, n = 379) and were inseminated 14-20 h later. Dephereline treatment increased corpus luteum (CL) size on Day 7 post-AI compared with GnRH (P < . Read More

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November 2018

Are tones in the expressive lexicon iconic? Evidence from three Chinese languages.

PLoS One 2018 4;13(12):e0204270. Epub 2018 Dec 4.

Department of Linguistics, University of Hong Kong, Hong Kong, S.A.R., China.

Recent advances in the literature have focused on sketching phonosemantic mappings of imitative or iconic utterances by relying on vowels and consonants, leaving the suprasegmental information unexplored. To begin bridging this gap, this study looks at the interaction of lexical tone and iconicity by comparing sound symbolic (i.e. Read More

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December 2018
1 Read

Anatomy of the Superficial Fascia System of the Breast: A Comprehensive Theory of Breast Fascial Anatomy.

Plast Reconstr Surg 2018 Nov;142(5):1135-1144

St. Petersburg and Bradenton, Fla.; and Lynchburg, Va. From plastic surgery private practice; OMS-II, Lake Erie College of Osteopathic Medicine; general surgery private practice; and general medicine private practice.

Background: It has been two centuries since Petrus Camper identified superficial fascia and over 175 years since Sir Astley Cooper wrote his book on the anatomy of the breast. In the 1990s, Ted Lockwood taught us the importance of the superficial fascia layers in body contouring procedures he pioneered. These descriptions, however, fail to explain the three-dimensional fascial system in the breast. Read More

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November 2018
2 Reads

Clinical Outcomes Following Prenatal Diagnosis of Asymmetric Ventriculomegaly, Interhemispheric Cyst, and Callosal Dysgenesis (AVID).

Prenat Diagn 2018 Dec 4. Epub 2018 Dec 4.

Department of Radiology, Oregon Health & Science University.

Objectives: When identified prenatally, the imaging triad of asymmetric ventriculomegaly, interhemispheric cyst, and dysgenesis of the corpus callosum (AVID) can indicate a more serious congenital brain anomaly. In this follow-up series of 15 fetuses, we present the neurodevelopmental outcomes of a single institution cohort of children diagnosed prenatally with AVID.

Methods: Our fetal ultrasound database was queried for cases of AVID between 2000 and 2016. Read More

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December 2018

GPR56 homozygous nonsense mutation p.R271* associated with phenotypic variability in bilateral frontoparietal polymicrogyria.

Turk J Pediatr 2018 ;60(3):229-237

Departments of Medical Biology and Genetics, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.

Öncü-Öner T, Ünalp A, Porsuk-Doru İ, Ağılkaya S, Güleryüz H, Saraç A, Ergüner B, Yüksel B, Hız-Kurul S, Cingöz S. GPR56 homozygous nonsense mutation p.R271* associated with phenotypic variability in bilateral frontoparietal polymicrogyria. Read More

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January 2018

Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia.

J Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.

Chronic inflammation of the gastric mucosa, often caused by autoimmune gastritis and/or infection with Helicobacter pylori, can lead to atrophy of acid-secreting parietal cells with metaplasia of remaining cells. The histological pattern marks a critical step in the progression from chronic gastritis to gastric cancer, yet underlying mechanism(s) of inflammation-induced cell death of gastric epithelial cells are poorly understood. We investigated direct effects of a type 1 cytokine associated with autoimmunity and infection, interferon-γ (IFN-γ), on gastric epithelial cells. Read More

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December 2018
1 Read

High-resolution imaging of distinct human corpus callosum microstructure and topography of structural connectivity to cortices at high field.

Brain Struct Funct 2018 Dec 3. Epub 2018 Dec 3.

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 Sixth Street SE, Minneapolis, MN, 55455, USA.

Characterization of the microstructural properties and topography of the human corpus callosum (CC) is key to understanding interhemispheric neural communication and brain function. In this work, we tested the hypothesis that high-resolution T relaxometry at high field has adequate sensitivity and specificity for characterizing microstructural properties of the human CC, and elucidating the structural connectivity of the callosal fibers to the cortices of origin. The high-resolution parametric T images acquired from healthy subjects (N = 16) at 7 T clearly showed a consistent T distribution among individuals with substantial variation along the human CC axis, which is highly similar to the spatial patterns of myelin density and myelinated axon size based on the histology study. Read More

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December 2018
2 Reads

A Median Artery of the Corpus Callosum.

Cureus 2018 Sep 25;10(9):e3355. Epub 2018 Sep 25.

Neurosurgery, Seattle Science Foundation, Seattle, USA.

The anterior communicating artery is one of the main components of the vascular network that delivers blood to the brain. Therefore, a good understanding of the normal anatomy and its variations is important to neurologists, neurosurgeons, and other health care providers dealing with the central nervous system. Here, we present a case of a median artery of the corpus callosum found in a cadaver, with consideration of cerebral hemodynamics implications. Read More

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September 2018
2 Reads

Potential oligogenic disease of mental retardation, short stature, spastic paraparesis, and osteopetrosis.

Appl Clin Genet 2018 8;11:129-134. Epub 2018 Nov 8.

Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia,

The interaction of multiple genetic factors, as opposed to monogenic inheritance, has been suspected to play a role in many diseases. This interaction has been described as an oligogenic inheritance model, which may be a useful tool in explaining certain clinical observations. The purpose of this study was to search for novel genetic defects among members of a family with traits that include mental retardation, short stature, osteopetrosis, calcification of basal ganglia, and thinning of the corpus callosum. Read More

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November 2018
1 Read

Seasonal expressions of luteinising hormone receptor, follicle-stimulating hormone receptor and prolactin receptor in the epididymis of the male wild ground squirrel (Spermophilus dauricus).

Reprod Fertil Dev 2018 Dec 4. Epub 2018 Dec 4.

Luteinising hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) are pituitary-derived hormones and mediate their functions through LH receptor (LHR), FSH receptor (FSHR) and PRL receptor (PRLR) respectively. This study aimed to investigate the seasonal expression patterns of LHR, FSHR and PRLR in the epididymis of the male wild ground squirrel during the breeding and non-breeding seasons. Histologically, principal cells, basal cells, cilia and mature spermatozoa were found in the lumen of caput, corpus and cauda epididymidis in the breeding season, whereas in the non-breeding season, cilia and basal cells were rarely found and the epididymidal duct was devoid of spermatozoa. Read More

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December 2018

Combination of conditional random field with a rule based method in the extraction of PICO elements.

BMC Med Inform Decis Mak 2018 Dec 4;18(1):128. Epub 2018 Dec 4.

Computer Science and Engineering Department, Université du Québec en Outaouais, Gatineau, J8Y 3G5, Canada.

Background: Extracting primary care information in terms of Patient/Problem, Intervention, Comparison and Outcome, known as PICO elements, is difficult as the volume of medical information expands and the health semantics is complex to capture it from unstructured information. The combination of the machine learning methods (MLMs) with rule based methods (RBMs) could facilitate and improve the PICO extraction. This paper studies the PICO elements extraction methods. Read More

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December 2018
1 Read

Impact of recombinant bovine somatotropin, progesterone, and estradiol benzoate on ovarian follicular dynamics in Bos taurus taurus cows using a protocol for estrus and ovulation synchronization.

Theriogenology 2018 Nov 17;125:331-334. Epub 2018 Nov 17.

Federal University of Paraná, Curitiba, Paraná State, Brazil.

This study aimed to evaluate the effect of recombinant bovine somatotropin (bST) in combination with progesterone (P4) and estradiol benzoate (EB) on ovarian follicular dynamics using a protocol for estrus and ovulation synchronization in crossbred Bos taurus taurus cows. Twenty-four non-lactating multiparous cows were randomly assigned to two groups: the recombinant bovine somatotropin group (GbST; n = 11) received an intravaginal P4 device (1.5 g), estradiol benzoate (EB = 1. Read More

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November 2018

Cytotoxic lesion of the corpus callosum exclusively at the genu in a case of callosal hypogenesis.

J Neuroradiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Pediatric Neurology, Fukuoka Children's Hospital, Fukuoka, Japan.

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November 2018

[Effect of high fat diet on proteome in mice stomachs].

Sheng Wu Gong Cheng Xue Bao 2018 Nov;34(11):1840-1849

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (The PHOENIX Center, Beijing), Beijing Institute of Life Omics, Beijing 102206, China.

To explore the effect of high fat diet on proteome in mice stomachs, we constructed a model in which the mice were fed with high fat diet as the high fat diet (HFD) group or normal diet as the control (CTRL) group for 110 days. The stomachs were collected and divided into three regions (forestomach (F), corpus (C) and antrum (A)) for protein extraction and mass spectrometry analysis. Of all 9 307 identified proteins in two groups, 4 066 proteins (HFD: 3 832, CTRL: 3 654) were strictly identified by at least one unique peptide and identified twice in three replicates. Read More

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November 2018

Vasoactive Intestinal Peptide Decreases β-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer's Disease.

J Mol Neurosci 2018 Nov 29. Epub 2018 Nov 29.

Department of Physiology, Faculty of Medicine, Eskisehir Osmangazi University, 26480, Eskisehir, Turkey.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular deposits of fibrillary β-amyloid (Aβ) plaques in the brain that initiate an inflammatory process resulting in neurodegeneration. The neuronal loss associated with AD results in gross atrophy of affected regions causing a progressive loss of cognitive ability and memory function, ultimately leading to dementia. Growing evidence suggests that vasoactive intestinal peptide (VIP) could be beneficial for various neurodegenerative diseases, including AD. Read More

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November 2018
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Penile Metastasis from Rectal Carcinoma: Case Report and Review of the Literature.

Visc Med 2018 Oct 31;34(5):389-392. Epub 2018 Jul 31.

Clinic of Internal Diseases, Family Medicine and Oncology, Faculty of Medicine, Vilnius University, National Cancer Institute, Vilnius, Lithuania.

Background: Metastasis of rectal cancer to the penis is a very rare condition with less than 40 cases found in the literature.

Case Report: We here report a case of a 41-year-old man who was diagnosed with rectal cancer which later metastasized to the penis. The patient was treated with neoadjuvant radiotherapy, underwent rectal resection, had adjuvant chemotherapy, and, despite that, had penile metastasis 2 years later. Read More

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October 2018

MRI Evidence of Altered Callosal Sodium in Mild Traumatic Brain Injury.

AJNR Am J Neuroradiol 2018 Nov 29. Epub 2018 Nov 29.

From the New York University Langone Medical Center, New York, New York.

Background And Purpose: Mild traumatic brain injury is a leading cause of death and disability worldwide with 42 million cases reported annually, increasing the need to understand the underlying pathophysiology because this could help guide the development of targeted therapy. White matter, particularly the corpus callosum, is susceptible to injury. Animal models suggest stretch-induced mechanoporation of the axonal membrane resulting in ionic shifts and altered sodium ion distribution. Read More

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November 2018

Validation of corpus callosotomy after laser interstitial thermal therapy: a multimodal approach.

Authors:

J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.

ObjectiveDisconnection of the cerebral hemispheres by corpus callosotomy (CC) is an established means to palliate refractory generalized epilepsy. Laser interstitial thermal therapy (LITT) is gaining acceptance as a minimally invasive approach to treating epilepsy, but this method has not been evaluated in clinical series using established methodologies to assess connectivity. The goal in this study was to demonstrate the safety and feasibility of MRI-guided LITT for CC and to assess disconnection by using electrophysiology- and imaging-based methods. Read More

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November 2018
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Chordoma of the corpus callosum: case report.

Authors:

J Neurosurg 2018 Nov 1:1-7. Epub 2018 Nov 1.

Chordomas are neoplasms that typically arise from midline skeletal structures and rarely originate within the intradural compartment of the CNS. A chordoma arising from the corpus callosum has not been previously described. The authors report the surgical management of a chordoma originating within the splenium of the corpus callosum. Read More

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November 2018
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