314 results match your criteria Corpus Luteum Rupture

An Unusual Presentation of a Corpus Luteum Rupture.

Gynecol Minim Invasive Ther 2022 Jan-Mar;11(1):57-60. Epub 2022 Feb 14.

Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

Rheumatic heart disease (RHD) is one of the most common cardiac conditions seen in India with mitral stenosis as the most prevalent cause affecting females more than males. With the increasing number of patients undergoing mitral valve replacement (MVR) and mandatory use of anticoagulants post-MVR, the patients presenting with drug-induced coagulopathy have increased. One of the rare complications of coagulopathy-related hemorrhage may be associated with a gynecological cause with maximum risk in women of reproductive age group. Read More

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February 2022

The impact of endometrial preparation for frozen embryo transfer on maternal and neonatal outcomes: a review.

Reprod Biol Endocrinol 2022 Feb 28;20(1):40. Epub 2022 Feb 28.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Emory University School of Medicine, Emory Reproductive Center, 550 Peachtree Street, 18th Floor, Atlanta, GA, 30308, USA.

The use of frozen embryo transfer in assisted reproductive technology (ART) has steadily increased since development in the early 1980's. While there are many benefits to delayed frozen embryo transfer, certain adverse perinatal outcomes are noted to be more common in these transfers when compared to fresh transfers, specifically hypertensive disorders of pregnancy. Frozen embryo transfers require coordination between the embryo's developmental stage and the endometrial environment and can occur in either ovulatory or programmed cycles. Read More

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February 2022

Diagnosis and Analysis of Transabdominal and Intracavitary Ultrasound in Gynecological Acute Abdomen.

Comput Math Methods Med 2021 29;2021:9508838. Epub 2021 Dec 29.

Department of Emergency, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201821, China.

In order to explore the effective diagnosis method of gynecological acute abdomen, this paper takes hospital gynecological acute abdomen patients as samples and selects gynecological acute abdomen patients admitted to the hospital to be included in this study. They are divided into transabdominal ultrasound group, intracavitary ultrasound group, and combined group. Moreover, this paper uses mathematical statistics to carry out sample statistics. Read More

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The predicting factors for indication of surgery in patients with hemoperitoneum caused by corpus luteum cyst rupture.

Sci Rep 2021 09 17;11(1):17766. Epub 2021 Sep 17.

Department of Obstetrics and Gynecology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, 807 Hogukro, Buk-gu, Daegu, 41404, Republic of Korea.

The aim of the study was to determine the risk factors for surgery in patients with hemoperitoneum caused by corpus luteum cyst rupture. A retrospective review of medical records of 155 patients diagnosed with hemoperitoneum caused by corpus luteum cyst rupture was conducted between January 2010 and March 2015. The patients were divided into two groups: surgical and conservative management. Read More

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September 2021

Abdominal hemorrhage after peritoneal dialysis catheter insertion: A rare cause of luteal rupture: A case report.

World J Clin Cases 2021 Aug;9(22):6510-6514

Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.

Background: Abdominal hemorrhage is a complication of peritoneal dialysis catheter (PDC) insertion that cannot be neglected, and its causes are mainly related to surgical injury. This article reports a case of massive abdominal hemorrhage that was caused by a rare rupture of corpus luteum shortly after PDC during the initiation of peritoneal dialysis (PD) insertion.

Case Summary: A 37-year-old woman was surgically placed a Tenckhoff catheter because of end-stage renal disease. Read More

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LH Induces De Novo Cholesterol Biosynthesis via SREBP Activation in Granulosa Cells During Ovulation in Female Mice.

Endocrinology 2021 11;162(11)

Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, Shobara, 727-0023, Japan.

In the liver, the sterol response element binding protein (SREBP) and the SREBP cleavage-activated protein (SCAP) complex upregulate cholesterol biosynthesis by gene induction of de novo cholesterol synthetic enzymes (Hmgcr, Cyp51, and Dhcr7). Insulin induced gene 1 (INSIG1) negatively regulates cholesterol biosynthesis by the inhibition of de novo cholesterol biosynthetic gene expression. In the ovary, cholesterol is de novo synthesized; however, the roles of SREBP and its regulators (SCAP and INSIG1) are not well understood. Read More

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November 2021

Vaginal temperature before calving assessed with wireless vaginal temperature sensor in dairy and beef cattle.

Theriogenology 2021 Sep 14;172:230-238. Epub 2021 Jul 14.

Kyushu Okinawa Agricultural Research Center, NARO, Kumamoto, Japan. Electronic address:

We evaluated the daily and hourly vaginal temperature changes and the relationships between the dams' breed and parity by using a commercially available vaginal temperature sensor in 72 Holstein (Hol) calvings and 101 Japanese Black (JB) calvings. Vaginal temperature sensors inserted 7-10 days before the expected calving day sounded two alerts: when the temperature fell below the threshold (Alert 1), and when the sensor reached the ambient temperature after falling out of the dam's vagina with the rupture of the allantoic sac (Alert 2). The durations from Alert 1 to Alert 2 (Time 1) and from Alert 2 to delivery (Time 2) were calculated. Read More

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September 2021

Diagnostic value of susceptibility-weighted imaging for endometrioma: preliminary results from a retrospective analysis.

Acta Radiol 2021 Jun 7:2841851211022495. Epub 2021 Jun 7.

Department of Medical Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

Background: Endometrioma is a common manifestation of endometriosis that can be difficult to diagnose with conventional magnetic resonance imaging (MRI). Susceptibility-weighted imaging (SWI) may be more sensitive than conventional MRI in the detection of chronic, local hemorrhagic disease.

Purpose: To investigate whether signal voids in SWI sequences could be used in the preoperative diagnosis of endometrioma. Read More

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Letrozole-induced frozen embryo transfer cycles are associated with a lower risk of hypertensive disorders of pregnancy among women with polycystic ovary syndrome.

Am J Obstet Gynecol 2021 07 30;225(1):59.e1-59.e9. Epub 2021 Jan 30.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Observational retrospective data suggest that an artificial cycle frozen embryo transfer may be associated with a higher risk of hypertensive disorder of pregnancy than a natural cycle frozen embryo transfer among women with regular ovulatory cycles. The corpus luteum, which is not present in the artificial frozen cycles, is at least partly responsible for this poor obstetrical outcome. However, an artificial cycle is the most frequently used regimen for women with polycystic ovary syndrome undergoing frozen embryo transfer. Read More

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Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET.

Fertil Steril 2021 04 16;115(4):947-956. Epub 2021 Jan 16.

Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Objective: To investigate whether obstetric and perinatal outcomes in pregnancies differ after different frozen embryo transfer (FET) protocols.

Design: Register-based cohort study.

Setting: Not applicable. Read More

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Hemorrhagic corpus luteum: Clinical management update.

Turk J Obstet Gynecol 2020 Dec 10;17(4):300-309. Epub 2020 Dec 10.

Veris Delli Ponti Hospital, Chief of Clinic of Obstetrics and Gynecology, Scorrano, Lecce, Italy.

Hemorrhagic corpus luteum (HCL) is an ovarian cyst formed after ovulation and caused by spontaneous bleeding into a corpus luteum (CL) cyst. When HCL rupture happens, a hemoperitoneum results. Clinical symptoms are mainly due to peritoneal irritation by the blood effusion. Read More

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December 2020

Repeated ruptures of corpus luteum in a female patient with alpha1-antitrypsin Pittsburgh.

Ann Hematol 2021 Mar 6;100(3):847-850. Epub 2020 Nov 6.

Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

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Identifying corpus luteum rupture as the culprit for haemoperitoneum.

Br J Radiol 2021 Jan 26;94(1117):20200383. Epub 2020 Aug 26.

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.

Corpus luteum rupture presenting as acute abdomen is an underdiagnosed condition. Though a self-limiting entity, its differentiation from other causes is essential to prevent unnecessary surgical procedures. The radiologist should be aware of the possibility of a ruptured haemorrhagic ovarian cyst in a female of reproductive age group presenting with pelvic pain and a large amount of haemorrhagic ascites. Read More

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January 2021

Minilaparotomic incision for haemorrhagic corpus luteum: a case report.

G Chir 2020 Jan-Feb;41(1):110-113

Corpus luteum cyst rupture with consequent hemoperitoneum is a common cause of admission to the emergency room. This condition is frequently misdiagnosed because of overlapping of clinical findings in acute gynecologic diseases. However, an incorrect identification may lead to delay in surgical treatment, which can Romabe a life-threatening condition. Read More

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November 2020

Thrombospondin 1 (THBS1) Promotes Follicular Angiogenesis, Luteinization, and Ovulation in Primates.

Front Endocrinol (Lausanne) 2019 7;10:727. Epub 2019 Nov 7.

Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, United States.

Angiogenesis is essential to both ovulation and the formation of the corpus luteum. The thrombospondin (THBS) family of glycoproteins plays diverse roles in regulation of angiogenesis, but the role of these vascular regulators in ovulation and luteinization remain to be elucidated. Using the cynomolgus macaque as a model for human ovulation, we demonstrated that levels of THBS1 mRNA and protein in preovulatory follicle granulosa cells increased after the ovulatory gonadotropin surge, with peak levels just before the expected time of ovulation. Read More

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November 2019


Acta Clin Croat 2018 Dec;57(4):785-788

1Rotunda IVF, Parnell Square, Dublin, Ireland; 2Department of Gynecology and Obstetrics, Sveti Duh University Hospital, Zagreb, Croatia.

- Rupture of the corpus luteum is a frequent condition in women of reproductive age. Because of abdominal pain accompanied by hemoperitoneum, ruptured corpus luteum can easily be confused with ectopic pregnancy. The management of ruptured corpus luteum depends on the symptoms and laboratory findings, and can be just observation but laparoscopy or urgent laparotomy may also be needed. Read More

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December 2018

Ultrasound classification and clinical analysis of ovarian pregnancy: A study of 12 cases.

J Gynecol Obstet Hum Reprod 2019 Nov 11;48(9):731-737. Epub 2019 Apr 11.

Department of Ultrasound, Qilu Hospital of Shandong University (Qingdao), Qingdao, China. Electronic address:

Objective: To evaluate the clinical significance of preoperative ultrasound diagnosis and classification of ovarian pregnancy (OP).

Methods: The ultrasonographic reports, medical records, and operative summaries were reviewed for twelve women with a confirmed diagnosis of OP. According to the ultrasonographic appearance, OP was classified into two types. Read More

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November 2019

Pregnancy-Preserving Laparoscopic Treatment of Acute Hemoperitoneum Following Lutein Cyst Rupture in Early Gestation.

Rafał Watrowski

Z Geburtshilfe Neonatol 2019 Apr 7;223(2):109-112. Epub 2019 Mar 7.

St. Josefskrankenhaus, Teaching Hospital of the University of Freiburg, Department of Gynecology and Obstetrics, Freiburg, Germany.

Acute hemoperitoneum (AHP) in early gestation is commonly treated via laparotomy. A ruptured corpus luteum (CL) cyst is a rare cause of AHP in pregnancy. This case report describes a 33-year-old, hemodynamically stable G2/P1 who presented at 5+5 gestational weeks with an acute abdomen due to ruptured CL cyst (7 cm). Read More

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Systematic Review of Ovarian Activity and Potential for Embryo Formation and Loss during the Use of Hormonal Contraception.

Linacre Q 2018 Nov 3;85(4):453-469. Epub 2019 Jan 3.

Saint Louis University, Saint Louis, MO, USA.

The purpose of this review was to determine whether there is evidence that ovulation can occur in women using hormonal contraceptives and whether these drugs might inhibit implantation. We performed a systematic review of the published English-language literature from 1990 to the present which included studies on the hormonal milieu following egg release in women using any hormonal contraceptive method. High circulating estrogens and progestins in the follicular phase appear to induce dysfunctional ovulation, where follicular rupture occurs but is followed by low or absent corpus luteum production of progesterone. Read More

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November 2018

Left-Right Asymmetry of Tubal Pregnancy: A 12-Year Retrospective Hospital-Based Study.

J Minim Invasive Gynecol 2019 May - Jun;26(4):671-678. Epub 2018 Jul 19.

Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China (Dr. Duan).. Electronic address:

Study Objective: To investigate whether there are left-right asymmetries, factors affecting lateral dominance, and clinical feature differences in the left and right sides of tubal pregnancy (TP).

Design: Retrospective study (Canadian Task Force classification II-2).

Setting: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University. Read More

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Coherent apoptotic and autophagic activities involved in regression of chicken postovulatory follicles.

Aging (Albany NY) 2018 04;10(4):819-832

Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.

After ovulation in mammals, rupture of mature follicles is reorganized into the corpus luteum that secrets progesterone (P) to stimulate endometrial development. The situation in birds differs considerably. Beyond ovulation the ruptured avian follicle forms a postovulatory follicle (POF) that is not considered analogous to mammalian corpus luteum. Read More

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Imaging the ovary.

Reprod Biomed Online 2018 May 6;36(5):584-593. Epub 2018 Mar 6.

Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address:

During each reproductive cycle, the ovary exhibits tissue remodelling and cyclic vasculature changes associated with hormonally regulated folliculogenesis, follicle rupture, luteal formation and regression. However, the relationships among different types of follicles and corpora lutea are unclear, and the role of ovarian vasculature in folliculogenesis and luteal dynamics has not been extensively investigated. Understanding of ovarian physiology and pathophysiology relies upon elucidation of ovarian morphology and architecture. Read More

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[α1-antitrypsin Pittsburg mutations: report of two cases in the same family].

Zhonghua Xue Ye Xue Za Zhi 2017 Nov;38(11):968-971

Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

To analyze the clinical and laboratory abnormalities of two patients with α1-antitrypsin (α1-AT) Pittsburgh in a family and review the literatures. Both plasma clotting time and factor activities were performed using clotting or substrate methods. Platelet aggregation was evaluated using an optical aggregometer. Read More

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November 2017

Placental Growth Factor Is Required for Ovulation, Luteinization, and Angiogenesis in Primate Ovulatory Follicles.

Endocrinology 2018 02;159(2):710-722

Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia.

Placental growth factor (PGF) is member of the vascular endothelial growth factor (VEGF) family of angiogenesis regulators. VEGFA is an established regulator of ovulation and formation of the corpus luteum. To determine whether PGF also mediates aspects of ovulation and luteinization, macaques received gonadotropins to stimulate multiple follicular development. Read More

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February 2018

Ruptured Corpus Luteal Cyst: Prediction of Clinical Outcomes with CT.

Korean J Radiol 2017 Jul-Aug;18(4):607-614. Epub 2017 May 19.

Department of Obstetrics and Gynecology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea.

Objective: To evaluate the determinant pretreatment CT findings that can predict surgical intervention for patients suffering from corpus luteal cyst rupture with hemoperitoneum.

Materials And Methods: From January 2009 to December 2014, a total of 106 female patients (mean age, 26.1 years; range, 17-44 years) who visited the emergency room of our institute for acute abdominal pain and were subsequently diagnosed with ruptured corpus luteal cyst with hemoperitoneum were included in the retrospective study. Read More

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October 2017

Possible role of PPARγ in the negative regulation of ovulatory cascade and luteal development in rats.

J Vet Med Sci 2017 Jun 19;79(6):1043-1051. Epub 2017 May 19.

Laboratory of Veterinary Physiology, Kitasato University School of Veterinary Medicine, Towada, Aomori 034-8628, Japan.

Peroxisome proliferator-activated receptor γ (PPARγ), a member of a nuclear receptor family, has been shown to be implicated in various reproductive processes. Here, we evaluated possible roles of PPARγ in ovulation and luteal development in a gonadotropins-primed immature rat model. Immunoreactive PPARγ was expressed in granulosa cells of eCG-stimulated mature follicles, and its expression level decreased following ovulatory hCG stimulus. Read More

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A novel nonsense NBEAL2 gene mutation causing severe bleeding in a patient with gray platelet syndrome.

Platelets 2018 May 15;29(3):288-291. Epub 2017 May 15.

a Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health , The First Affiliated Hospital of Soochow University , Suzhou , China.

Gray platelet syndrome (GPS) is a rare, inherited bleeding disorder characterized by the defect of platelet α-granule. Up to date, these are only four studies identifying NBEAL2 gene correlated with GPS. In the current report, we present a Chinese GPS patient who had severe bleeding tendency, abnormalities of platelet functions, and absence of platelet α-granules. Read More

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Induction of Tissue Factor Pathway Inhibitor 2 by hCG Regulates Periovulatory Gene Expression and Plasmin Activity.

Endocrinology 2017 01;158(1):109-120

Department of Obstetrics and Gynecology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536; and.

Increased proteolytic activity is a key event that aids in breakdown of the follicular wall to permit oocyte release. How the protease activity is regulated is still unknown. We hypothesize that tissue factor pathway inhibitor 2 (TFPI2), a Kunitz-type serine protease inhibitor, plays a role in regulating periovulatory proteolytic activity as in other tissues. Read More

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January 2017

Knockdown of Progesterone Receptor (PGR) in Macaque Granulosa Cells Disrupts Ovulation and Progesterone Production.

Biol Reprod 2016 05 16;94(5):109. Epub 2016 Mar 16.

Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.

Adenoviral vectors (vectors) expressing short-hairpin RNAs complementary to macaque nuclear progesterone (P) receptor PGR mRNA (shPGR) or a nontargeting scrambled control (shScram) were used to determine the role PGR plays in ovulation/luteinization in rhesus monkeys. Nonluteinized granulosa cells collected from monkeys (n = 4) undergoing controlled ovarian stimulation protocols were exposed to either shPGR, shScram, or no virus for 24 h; human chorionic gonadotropin (hCG) was then added to half of the wells to induce luteinization (luteinized granulosa cells [LGCs]; n = 4-6 wells/treatment/monkey). Cells/media were collected 48, 72, and 120 h postvector for evaluation of PGR mRNA and P levels. Read More

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