306 results match your criteria Corpus Luteum Rupture

Letrozole-induced frozen embryo transfer cycles are associated with a lower risk of hypertensive disorders of pregnancy among women with polycystic ovary syndrome.

Am J Obstet Gynecol 2021 Jan 30. Epub 2021 Jan 30.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Observational retrospective data suggest that an artificial cycle frozen embryo transfer may be associated with a higher risk of hypertensive disorder of pregnancy than a natural cycle frozen embryo transfer among women with regular ovulatory cycles. The corpus luteum, which is not present in the artificial frozen cycles, is at least partly responsible for this poor obstetrical outcome. However, an artificial cycle is the most frequently used regimen for women with polycystic ovary syndrome undergoing frozen embryo transfer. Read More

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January 2021

Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET.

Fertil Steril 2021 Apr 16;115(4):947-956. Epub 2021 Jan 16.

Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Objective: To investigate whether obstetric and perinatal outcomes in pregnancies differ after different frozen embryo transfer (FET) protocols.

Design: Register-based cohort study.

Setting: Not applicable. Read More

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Hemorrhagic corpus luteum: Clinical management update.

Turk J Obstet Gynecol 2020 Dec 10;17(4):300-309. Epub 2020 Dec 10.

Veris Delli Ponti Hospital, Chief of Clinic of Obstetrics and Gynecology, Scorrano, Lecce, Italy.

Hemorrhagic corpus luteum (HCL) is an ovarian cyst formed after ovulation and caused by spontaneous bleeding into a corpus luteum (CL) cyst. When HCL rupture happens, a hemoperitoneum results. Clinical symptoms are mainly due to peritoneal irritation by the blood effusion. Read More

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December 2020

Repeated ruptures of corpus luteum in a female patient with alpha1-antitrypsin Pittsburgh.

Ann Hematol 2021 Mar 6;100(3):847-850. Epub 2020 Nov 6.

Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

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Identifying corpus luteum rupture as the culprit for haemoperitoneum.

Br J Radiol 2021 Jan 26;94(1117):20200383. Epub 2020 Aug 26.

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.

Corpus luteum rupture presenting as acute abdomen is an underdiagnosed condition. Though a self-limiting entity, its differentiation from other causes is essential to prevent unnecessary surgical procedures. The radiologist should be aware of the possibility of a ruptured haemorrhagic ovarian cyst in a female of reproductive age group presenting with pelvic pain and a large amount of haemorrhagic ascites. Read More

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January 2021

Minilaparotomic incision for haemorrhagic corpus luteum: a case report.

G Chir 2020 Jan-Feb;41(1):110-113

Corpus luteum cyst rupture with consequent hemoperitoneum is a common cause of admission to the emergency room. This condition is frequently misdiagnosed because of overlapping of clinical findings in acute gynecologic diseases. However, an incorrect identification may lead to delay in surgical treatment, which can Romabe a life-threatening condition. Read More

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November 2020

Thrombospondin 1 (THBS1) Promotes Follicular Angiogenesis, Luteinization, and Ovulation in Primates.

Front Endocrinol (Lausanne) 2019 7;10:727. Epub 2019 Nov 7.

Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, United States.

Angiogenesis is essential to both ovulation and the formation of the corpus luteum. The thrombospondin (THBS) family of glycoproteins plays diverse roles in regulation of angiogenesis, but the role of these vascular regulators in ovulation and luteinization remain to be elucidated. Using the cynomolgus macaque as a model for human ovulation, we demonstrated that levels of THBS1 mRNA and protein in preovulatory follicle granulosa cells increased after the ovulatory gonadotropin surge, with peak levels just before the expected time of ovulation. Read More

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November 2019


Acta Clin Croat 2018 Dec;57(4):785-788

1Rotunda IVF, Parnell Square, Dublin, Ireland; 2Department of Gynecology and Obstetrics, Sveti Duh University Hospital, Zagreb, Croatia.

- Rupture of the corpus luteum is a frequent condition in women of reproductive age. Because of abdominal pain accompanied by hemoperitoneum, ruptured corpus luteum can easily be confused with ectopic pregnancy. The management of ruptured corpus luteum depends on the symptoms and laboratory findings, and can be just observation but laparoscopy or urgent laparotomy may also be needed. Read More

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December 2018

Ultrasound classification and clinical analysis of ovarian pregnancy: A study of 12 cases.

J Gynecol Obstet Hum Reprod 2019 Nov 11;48(9):731-737. Epub 2019 Apr 11.

Department of Ultrasound, Qilu Hospital of Shandong University (Qingdao), Qingdao, China. Electronic address:

Objective: To evaluate the clinical significance of preoperative ultrasound diagnosis and classification of ovarian pregnancy (OP).

Methods: The ultrasonographic reports, medical records, and operative summaries were reviewed for twelve women with a confirmed diagnosis of OP. According to the ultrasonographic appearance, OP was classified into two types. Read More

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November 2019

Pregnancy-Preserving Laparoscopic Treatment of Acute Hemoperitoneum Following Lutein Cyst Rupture in Early Gestation.

Rafał Watrowski

Z Geburtshilfe Neonatol 2019 Apr 7;223(2):109-112. Epub 2019 Mar 7.

St. Josefskrankenhaus, Teaching Hospital of the University of Freiburg, Department of Gynecology and Obstetrics, Freiburg, Germany.

Acute hemoperitoneum (AHP) in early gestation is commonly treated via laparotomy. A ruptured corpus luteum (CL) cyst is a rare cause of AHP in pregnancy. This case report describes a 33-year-old, hemodynamically stable G2/P1 who presented at 5+5 gestational weeks with an acute abdomen due to ruptured CL cyst (7 cm). Read More

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Systematic Review of Ovarian Activity and Potential for Embryo Formation and Loss during the Use of Hormonal Contraception.

Linacre Q 2018 Nov 3;85(4):453-469. Epub 2019 Jan 3.

Saint Louis University, Saint Louis, MO, USA.

The purpose of this review was to determine whether there is evidence that ovulation can occur in women using hormonal contraceptives and whether these drugs might inhibit implantation. We performed a systematic review of the published English-language literature from 1990 to the present which included studies on the hormonal milieu following egg release in women using any hormonal contraceptive method. High circulating estrogens and progestins in the follicular phase appear to induce dysfunctional ovulation, where follicular rupture occurs but is followed by low or absent corpus luteum production of progesterone. Read More

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November 2018

Left-Right Asymmetry of Tubal Pregnancy: A 12-Year Retrospective Hospital-Based Study.

J Minim Invasive Gynecol 2019 May - Jun;26(4):671-678. Epub 2018 Jul 19.

Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China (Dr. Duan).. Electronic address:

Study Objective: To investigate whether there are left-right asymmetries, factors affecting lateral dominance, and clinical feature differences in the left and right sides of tubal pregnancy (TP).

Design: Retrospective study (Canadian Task Force classification II-2).

Setting: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University. Read More

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Coherent apoptotic and autophagic activities involved in regression of chicken postovulatory follicles.

Aging (Albany NY) 2018 04;10(4):819-832

Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.

After ovulation in mammals, rupture of mature follicles is reorganized into the corpus luteum that secrets progesterone (P) to stimulate endometrial development. The situation in birds differs considerably. Beyond ovulation the ruptured avian follicle forms a postovulatory follicle (POF) that is not considered analogous to mammalian corpus luteum. Read More

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Imaging the ovary.

Reprod Biomed Online 2018 May 6;36(5):584-593. Epub 2018 Mar 6.

Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address:

During each reproductive cycle, the ovary exhibits tissue remodelling and cyclic vasculature changes associated with hormonally regulated folliculogenesis, follicle rupture, luteal formation and regression. However, the relationships among different types of follicles and corpora lutea are unclear, and the role of ovarian vasculature in folliculogenesis and luteal dynamics has not been extensively investigated. Understanding of ovarian physiology and pathophysiology relies upon elucidation of ovarian morphology and architecture. Read More

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[α1-antitrypsin Pittsburg mutations: report of two cases in the same family].

Zhonghua Xue Ye Xue Za Zhi 2017 Nov;38(11):968-971

Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

To analyze the clinical and laboratory abnormalities of two patients with α1-antitrypsin (α1-AT) Pittsburgh in a family and review the literatures. Both plasma clotting time and factor activities were performed using clotting or substrate methods. Platelet aggregation was evaluated using an optical aggregometer. Read More

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November 2017

Placental Growth Factor Is Required for Ovulation, Luteinization, and Angiogenesis in Primate Ovulatory Follicles.

Endocrinology 2018 02;159(2):710-722

Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia.

Placental growth factor (PGF) is member of the vascular endothelial growth factor (VEGF) family of angiogenesis regulators. VEGFA is an established regulator of ovulation and formation of the corpus luteum. To determine whether PGF also mediates aspects of ovulation and luteinization, macaques received gonadotropins to stimulate multiple follicular development. Read More

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February 2018

Ruptured Corpus Luteal Cyst: Prediction of Clinical Outcomes with CT.

Korean J Radiol 2017 Jul-Aug;18(4):607-614. Epub 2017 May 19.

Department of Obstetrics and Gynecology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea.

Objective: To evaluate the determinant pretreatment CT findings that can predict surgical intervention for patients suffering from corpus luteal cyst rupture with hemoperitoneum.

Materials And Methods: From January 2009 to December 2014, a total of 106 female patients (mean age, 26.1 years; range, 17-44 years) who visited the emergency room of our institute for acute abdominal pain and were subsequently diagnosed with ruptured corpus luteal cyst with hemoperitoneum were included in the retrospective study. Read More

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October 2017

Possible role of PPARγ in the negative regulation of ovulatory cascade and luteal development in rats.

J Vet Med Sci 2017 Jun 19;79(6):1043-1051. Epub 2017 May 19.

Laboratory of Veterinary Physiology, Kitasato University School of Veterinary Medicine, Towada, Aomori 034-8628, Japan.

Peroxisome proliferator-activated receptor γ (PPARγ), a member of a nuclear receptor family, has been shown to be implicated in various reproductive processes. Here, we evaluated possible roles of PPARγ in ovulation and luteal development in a gonadotropins-primed immature rat model. Immunoreactive PPARγ was expressed in granulosa cells of eCG-stimulated mature follicles, and its expression level decreased following ovulatory hCG stimulus. Read More

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A novel nonsense NBEAL2 gene mutation causing severe bleeding in a patient with gray platelet syndrome.

Platelets 2018 May 15;29(3):288-291. Epub 2017 May 15.

a Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health , The First Affiliated Hospital of Soochow University , Suzhou , China.

Gray platelet syndrome (GPS) is a rare, inherited bleeding disorder characterized by the defect of platelet α-granule. Up to date, these are only four studies identifying NBEAL2 gene correlated with GPS. In the current report, we present a Chinese GPS patient who had severe bleeding tendency, abnormalities of platelet functions, and absence of platelet α-granules. Read More

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Induction of Tissue Factor Pathway Inhibitor 2 by hCG Regulates Periovulatory Gene Expression and Plasmin Activity.

Endocrinology 2017 01;158(1):109-120

Department of Obstetrics and Gynecology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536; and.

Increased proteolytic activity is a key event that aids in breakdown of the follicular wall to permit oocyte release. How the protease activity is regulated is still unknown. We hypothesize that tissue factor pathway inhibitor 2 (TFPI2), a Kunitz-type serine protease inhibitor, plays a role in regulating periovulatory proteolytic activity as in other tissues. Read More

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January 2017

Knockdown of Progesterone Receptor (PGR) in Macaque Granulosa Cells Disrupts Ovulation and Progesterone Production.

Biol Reprod 2016 05 16;94(5):109. Epub 2016 Mar 16.

Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.

Adenoviral vectors (vectors) expressing short-hairpin RNAs complementary to macaque nuclear progesterone (P) receptor PGR mRNA (shPGR) or a nontargeting scrambled control (shScram) were used to determine the role PGR plays in ovulation/luteinization in rhesus monkeys. Nonluteinized granulosa cells collected from monkeys (n = 4) undergoing controlled ovarian stimulation protocols were exposed to either shPGR, shScram, or no virus for 24 h; human chorionic gonadotropin (hCG) was then added to half of the wells to induce luteinization (luteinized granulosa cells [LGCs]; n = 4-6 wells/treatment/monkey). Cells/media were collected 48, 72, and 120 h postvector for evaluation of PGR mRNA and P levels. Read More

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PDGFR Inhibition Results in Pericyte Depletion and Hemorrhage into the Corpus Luteum of the Rat Ovary.

Toxicol Pathol 2016 Jan 3;44(1):98-111. Epub 2015 Nov 3.

AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire, UK.

The growth plate, ovary, adrenal gland, and rodent incisor tooth are sentinel organs for antiangiogenic effects since they respond reliably, quantitatively, and sensitively to inhibition of the vascular endothelial growth factor receptor (VEGFR). Here we report that treatment of rats with platelet-derived growth factor receptor beta (PDGFRβ) inhibitors that target pericytes results in severe ovarian hemorrhage with degeneration and eventual rupture of the corpus luteum. Evaluation of the growth plate, adrenal gland, and incisor tooth that are typical target organs for antiangiogenic treatment in the rodent revealed no abnormalities. Read More

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January 2016

A Huge Mature Cystic Teratoma in a Nulliparous Patient.

J Clin Diagn Res 2015 Sep 1;9(9):QD03-4. Epub 2015 Sep 1.

Faculty, Department of Obstetrics and Gynecology, Acibadem Hospital , Bakirkoy/Istanbul .

Here we report a case of a giant mature cystic teratoma of the ovary in a 38-year-old nullipaous woman. The patient presented with abdominal distension and abdominal pain. Laparotomy and cystectomy yielded satisfactory results. Read More

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September 2015

A Follicle Rupture Assay Reveals an Essential Role for Follicular Adrenergic Signaling in Drosophila Ovulation.

PLoS Genet 2015 Oct 16;11(10):e1005604. Epub 2015 Oct 16.

Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, United States of America; Institute for Systems Genomics, University of Connecticut, Storrs, Connecticut, United States of America.

Ovulation is essential for the propagation of the species and involves a proteolytic degradation of the follicle wall for the release of the fertilizable oocyte. However, the precise mechanisms for regulating these proteolytic events are largely unknown. Work from our lab and others have shown that there are several parallels between Drosophila and mammalian ovulation at both the cellular and molecular levels. Read More

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October 2015

Massive hemoperitoneum due to a ruptured corpus luteum cyst in a patient with congenital hypofibrinogenemia.

Obstet Gynecol Sci 2015 Sep 22;58(5):427-30. Epub 2015 Sep 22.

Department of Obstetrics and Gynecology, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Korea.

Congenital afibrinogenemia/hypofibrinogenemia is a rare inherited hematologic disorder in which a patient lacks or has insufficient level of fibrinogen, the blood coagulation factor I. The incidence of this uncommon disease is 1 to 2 per 1 million individuals. Hence, massive hemoperitoneum caused by ovulation in a woman with congenital afibrogenemia is also a very rare clinical condition. Read More

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September 2015

A prospective, randomized, pharmacodynamic study of quick-starting a desogestrel progestin-only pill following ulipristal acetate for emergency contraception.

Hum Reprod 2015 Dec 23;30(12):2785-93. Epub 2015 Sep 23.

Dinox, Hanzeplein 1, Entrance 53, Groningen 9713 GZ, The Netherlands.

Study Question: Is there a pharmacodynamic interaction between ulipristal acetate (UPA) 30 mg for emergency contraception and a daily progestin-only contraceptive pill, desogestrel (DSG) 0.75 mg, when initiated the next day?

Summary Answer: In this study, DSG impaired the ability of UPA to delay ovulation, but UPA had little impact on the onset of contraceptive effects due to DSG.

What Is Known Already: UPA is a progesterone receptor modulator used for emergency contraceptive (EC) at the dose of 30 mg. Read More

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December 2015

Ruptured Hemorrhagic Corpus Luteum Cyst in an Undescended Ovary: A Rare Cause of Acute Abdomen.

J Pediatr Adolesc Gynecol 2016 Feb 25;29(1):e21-4. Epub 2015 Sep 25.

Department of Obstetrics and Gynecology, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Background: Undescended ovaries are typically detected during infertility evaluations and are frequently associated with uterine malformations. Ruptured hemorrhagic corpus luteum cyst of an undescended ovary is an unusual cause of acute abdomen in an adolescent.

Case: A 15-year-old girl presented with right lower quadrant pain, nausea, and vomiting, and transabdominal sonography and magnetic resonance imaging of the pelvis showed a 10 cm × 5 cm sized cystic mass at the level of the pelvic brim, anterior to the psoas muscle suggestive of a retroperitoneal hemorrhagic cyst. Read More

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February 2016

Diagnostic dilemma in ovarian pregnancy: a case series.

J Clin Diagn Res 2015 Apr 1;9(4):QR01-3. Epub 2015 Apr 1.

Associate Professor, Department of Obstetrics and Gynecology, Mahatama Gandhi Medical College and Research Institute , Puducherry, India .

Ovarian pregnancy is a rare form of ectopic pregnancy but it is the most common type of nontubal ectopic pregnancy. Many times it is operated with a misdiagnosis of ruptured tubal ectopic pregnancy or hemorrhagic corpus luteum. The high resolution transvaginal ultrasonography is a valuable tool for diagnosis of ectopic pregnancy but ovarian pregnancy still remains a diagnostic problem and a continuous challenge to the gynecologist. Read More

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Hemoperitoneum from corpus luteum rupture in patients with aplastic anemia.

Clin Lab 2015 ;61(3-4):427-30

Background: Aplastic anemia is a rare hematopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow. Women with aplastic anemia usually are at increased risk of corpus luteum rupture due to thrombocytopenia and infection.

Methods: Here we report two cases had hemoperitoneum from corpus luteum rupture in patients with aplastic anemia in our center. Read More

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