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Medicine (Baltimore) 2023 Jul;102(27):e34238

Department of Reproductive, Guizhou Provincial People's Hospital, Guiyang City, Guizhou Province, China.

Introduction: Ovarian hyperstimulation syndrome (OHSS) is a common complication during assisted conception treatment, mostly seen in patients with ovarian hyperresponsiveness such as polycystic ovary syndrome, especially in post-invitro fertilization and embryo transfer (IVF-ET) pregnancies. Its main symptoms are abdominal distension, abdominal pain, nausea and vomiting with ascites, pleural fluid, leukocytosis, hemoconcentration and hypercoagulation. This disease is a self-limiting disease and can be gradually cured by rehydration, albumin infusion and correction of electrolyte disorders in moderate to severe cases. Read More

JNMA J Nepal Med Assoc 2023 Feb 1;61(258):137-140. Epub 2023 Feb 1.

Department of Cardiothoracic and Vascular Surgery, Manmohan Cardiothoracic Vascular and Transplant Centre, Maharajgunj, Kathmandu, Nepal.

Introduction: Rupture of the corpus luteum, though generally self-limiting in women with normal coagulation, could lead to life-threatening bleeding in patients with prosthetic valves on anticoagulant therapy and described in only a few case reports in the literature. The aim of this study was to find out the prevalence of ruptured corpus luteum among women undergoing laparotomy for hemoperitoneum in a tertiary care centre.

Methods: This descriptive cross-sectional study was conducted among women undergoing laparotomy for hemoperitoneum in a tertiary centre from 7 April 2017 to 31 March 2021 after obtaining ethical approval from the Institutional Review Committee [Reference number: 328(6-11-E)2/73/74]. Read More

JNMA J Nepal Med Assoc 2023 Feb 1;61(258). Epub 2023 Feb 1.

Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

Introduction: Rupture of the corpus luteum, though generally self-limiting in women with normal coagulation, could lead to life-threatening bleeding in patients with prosthetic valves on anticoagulant therapy and described in only a few case reports in the literature. The aim of this study was to find out the prevalence of ruptured corpus luteum among women undergoing laparotomy for hemoperitoneum in a tertiary care centre.

Methods: This descriptive cross-sectional study was conducted among women undergoing laparotomy for hemoperitoneum in a tertiary centre from 7 April 2017 to 31 March 2021 after obtaining ethical approval from the Institutional Review Committee [Reference number: 328(6-11-E)2/73/74]. Read More

Cureus 2023 Apr 3;15(4):e37067. Epub 2023 Apr 3.

Trauma and Acute Care Surgery, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.

In the case of trauma, the presence of free fluid in the abdominal cavity on the focused assessment with sonography for trauma scan usually indicates the possibility of hemoperitoneum caused by injury to the abdominal organs. However, on rare occasions, isolated injuries to gynecologic organs can also result in hemoperitoneum, especially among women of reproductive age. Thus, the rupture of a corpus luteal cyst may be one of the myriad causes of massive hemoperitoneum and carries a risk of misdiagnosis for patients with trauma. Read More

Heliyon 2023 Feb 24;9(2):e13218. Epub 2023 Jan 24.

The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.

Study Question: In a modified natural cycle frozen-thawed embryo transfer (mNC-FET), does the premature timing of progesterone luteal phase support (LPS) initiation 24 h following human chorionic gonadotropin (hCG) trigger impact live birth?

Summary Answer: Premature LPS initiation did not negatively affect the live birth rate (LBR) in mNC-FET cycles compared with conventional LPS initiation 48 h after hCG triggering.

What Is Known Already: During natural cycle FET, human chorionic gonadotropin is routinely used to mimic endogenous luteinizing hormone (LH) surge to induce ovulation, which allows more flexibility in embryo transfer scheduling, thus relieving the burden of multiple visits by patients and laboratory workloads, which is also known as mNC-FET. Moreover, recent data demonstrates that ovulatory women undergoing natural cycle FETs have a lower risk of maternal and fetal complications due to the essential role of the corpus luteum in implantation, placentation and pregnancy maintenance. Read More

Cureus 2023 Jan 12;15(1):e33674. Epub 2023 Jan 12.

Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Wardha, IND.

When a patient is receiving anticoagulant therapy, the rupture of a corpus luteum cyst may go unrecognized in healthy women but becomes clinically relevant as it might exacerbate a hemoperitoneum episode. This report describes the case of a 26-year-old primipara who underwent surgical treatment for a heart defect and later experienced extensive hemoperitoneum. The patient reported to the casualty with symptoms of unstable hemodynamic status such as hypotension 90/60 mmHg and tachycardia 120 beats/minute. Read More

J Obstet Gynaecol India 2022 Dec 17;72(Suppl 2):435-438. Epub 2022 Feb 17.

Department of Internal Medicine, Mohak Hospital, Prayagraj, U.P. India.

Hemorrhagic ovarian cysts (HOCs) are frequently seen in reproductive age women, developing in the luteal phase of ovulatory cycles. Giant HOCs are rare, as bleeding inside a closed space causes acute pain leading to early diagnosis. Anovulation or oligoovulation is a defining feature of polycystic ovarian syndrome (PCOS), and hence, functional cysts are uncommon in PCOS patients. Read More

Front Cell Dev Biol 2022 3;10:1010601. Epub 2022 Nov 3.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.

Ovarian follicles are the fundamental structure to support oocyte development, which provides mature oocytes for offspring. This process requires granulosa cells (GCs) to respond to the midcycle surge of hormones, leading to GC proliferation and differentiation by a series of genes' transcriptional expression changes. Epigenetic mediator, Polycomb Repressive Complex 1 (PRC1) has been reported to function in fetal ovarian development. Read More

J Minim Invasive Gynecol 2023 Feb 13;30(2):83-84. Epub 2022 Nov 13.

Department of Obstetrics and Gynecology, Ageo Central Hospital, Saitama, Japan (Drs. Katakura, Suzuki, Namihira, Ezawa, Furukawa, and Nakakuma).

Medicine (Baltimore) 2022 Oct;101(43):e31643

Department of Nephrology, West China Hospital of Sichuan University, Chengdu, China.

Rationale: Anti-glomerular basement membrane (anti-GBM) disease during gestation is sparse and even rarer when combined with bilateral large corpus luteum cysts. In this case, we report a case of anti-GBM disease in the early stage of pregnancy with ruptured newly formed bilateral large corpus luteum cysts.

Patient Concerns: A 24-year-old female was initially diagnosed with anti-GBM disease. Read More

Cureus 2022 Sep 20;14(9):e29350. Epub 2022 Sep 20.

Emergency Medicine, HCA Florida Ocala Hospital, Ocala, USA.

Despite the relatively high incidence of ovarian cysts, particularly in premenopausal women, cyst rupture may on occasion present painfully and require surgical intervention to resolve. Particularly in the case of ruptured hemorrhagic ovarian cysts, resulting hemoperitoneum can create a risk of further adverse events including hypovolemic shock; proper identification and management of such cases are therefore critical. This case focuses on a 22-year-old female that presented to the emergency department (ED) with suprapubic pain in the lower left quadrant of the abdomen. Read More

Ann Med Surg (Lond) 2022 Oct 27;82:104765. Epub 2022 Sep 27.

Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Introduction: Large cystic masses are rare in pregnancy. Corpus luteum cysts and theca lutein cysts are common are most common among all. Ovarian masses are usually discovered as an incidental finding during routine obstetric ultrasonography. Read More

BMC Womens Health 2022 Oct 11;22(1):418. Epub 2022 Oct 11.

Department of Gynecology, Jieyang People's Hospital, Tianfu Road No.107, Rongcheng District, Jieyang, 522000, Guangdong, People's Republic of China.

Background: The rupture of the corpus luteum (CL) may occur at all stages of a woman's reproductive life. Bleeding of the ruptured CL varies from self-limiting hemorrhage to massive hemoperitoneum, causing the shock and subsequent emergency surgery. But hemoperitoneum secondary to ruptured CL is a rare complication and situation for women with bleeding disorders. Read More

Surg Technol Int 2022 Jun 23;41. Epub 2022 Jun 23.

Department of Minimally Invasive Surgery Unit of Centro Hospitalar Universitário do Porto, Porto, Portugal.

This review summarizes the evidence-based recommendations for how to approach and laparoscopically treat adnexal masses during pregnancy. We conducted a comprehensive review of studies related to the laparoscopic management of adnexal masses during pregnancy. Selected studies were independently reviewed by two authors. Read More

Emerg Radiol 2022 Oct 31;29(5):833-843. Epub 2022 May 31.

Department of Radiology, Northwestern University, Chicago, IL, USA.

Purpose: Hemoperitoneum caused by ovarian cyst rupture may necessitate intervention. The literature is lacking in descriptions of CT findings that help guide patient management. The purpose of this study is to consider CT findings associated with a need for intervention (surgical or interventional radiology management) versus conservative treatment (observation, pain management, and blood transfusions). Read More

Gynecol Minim Invasive Ther 2022 14;11(1):57-60. Epub 2022 Feb 14.

Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

Rheumatic heart disease (RHD) is one of the most common cardiac conditions seen in India with mitral stenosis as the most prevalent cause affecting females more than males. With the increasing number of patients undergoing mitral valve replacement (MVR) and mandatory use of anticoagulants post-MVR, the patients presenting with drug-induced coagulopathy have increased. One of the rare complications of coagulopathy-related hemorrhage may be associated with a gynecological cause with maximum risk in women of reproductive age group. Read More

Reprod Biol Endocrinol 2022 Feb 28;20(1):40. Epub 2022 Feb 28.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Emory University School of Medicine, Emory Reproductive Center, 550 Peachtree Street, 18th Floor, Atlanta, GA, 30308, USA.

The use of frozen embryo transfer in assisted reproductive technology (ART) has steadily increased since development in the early 1980's. While there are many benefits to delayed frozen embryo transfer, certain adverse perinatal outcomes are noted to be more common in these transfers when compared to fresh transfers, specifically hypertensive disorders of pregnancy. Frozen embryo transfers require coordination between the embryo's developmental stage and the endometrial environment and can occur in either ovulatory or programmed cycles. Read More

Comput Math Methods Med 2021 29;2021:9508838. Epub 2021 Dec 29.

Department of Emergency, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201821, China.

In order to explore the effective diagnosis method of gynecological acute abdomen, this paper takes hospital gynecological acute abdomen patients as samples and selects gynecological acute abdomen patients admitted to the hospital to be included in this study. They are divided into transabdominal ultrasound group, intracavitary ultrasound group, and combined group. Moreover, this paper uses mathematical statistics to carry out sample statistics. Read More

Cell Mol Biol (Noisy-le-grand) 2021 Nov 25;67(3):69-75. Epub 2021 Nov 25.

Assisted Reproductive Technology, College of Medicine, Hawler Medical University.

Gender determination, in addition to having special value to parents, has particular importance in sex-linked diseases. This study aimed to investigate the cellular indicators (i.e. Read More

Sci Rep 2021 Sep 17;11(1):17766. Epub 2021 Sep 17.

Department of Obstetrics and Gynecology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, 807 Hogukro, Buk-gu, Daegu, 41404, Republic of Korea.

The aim of the study was to determine the risk factors for surgery in patients with hemoperitoneum caused by corpus luteum cyst rupture. A retrospective review of medical records of 155 patients diagnosed with hemoperitoneum caused by corpus luteum cyst rupture was conducted between January 2010 and March 2015. The patients were divided into two groups: surgical and conservative management. Read More

World J Clin Cases 2021 Aug;9(22):6510-6514

Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.

Background: Abdominal hemorrhage is a complication of peritoneal dialysis catheter (PDC) insertion that cannot be neglected, and its causes are mainly related to surgical injury. This article reports a case of massive abdominal hemorrhage that was caused by a rare rupture of corpus luteum shortly after PDC during the initiation of peritoneal dialysis (PD) insertion.

Case Summary: A 37-year-old woman was surgically placed a Tenckhoff catheter because of end-stage renal disease. Read More

Front Med (Lausanne) 2021 9;8:669793. Epub 2021 Aug 9.

Department of Critical-Care Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, China.

Klippel-Trenaunay Syndrome (KTS) is a rare congenital disorder, characterized by venous and lymphatic malformations of the skin, soft tissue, and bone, causing limb hypertrophy. Although, a ruptured hemorrhagic corpus luteum is a rare condition in women of reproductive age, it can result in lethal outcomes. Here, we have described a patient with KTS and hypofibrinogenemia who went through recurrent lethal postoperative bleeding due to a ruptured hemorrhagic corpus luteum. Read More

Endocrinology 2021 Nov;162(11)

Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, Shobara, 727-0023, Japan.

In the liver, the sterol response element binding protein (SREBP) and the SREBP cleavage-activated protein (SCAP) complex upregulate cholesterol biosynthesis by gene induction of de novo cholesterol synthetic enzymes (Hmgcr, Cyp51, and Dhcr7). Insulin induced gene 1 (INSIG1) negatively regulates cholesterol biosynthesis by the inhibition of de novo cholesterol biosynthetic gene expression. In the ovary, cholesterol is de novo synthesized; however, the roles of SREBP and its regulators (SCAP and INSIG1) are not well understood. Read More

Theriogenology 2021 Sep 14;172:230-238. Epub 2021 Jul 14.

Kyushu Okinawa Agricultural Research Center, NARO, Kumamoto, Japan. Electronic address:

We evaluated the daily and hourly vaginal temperature changes and the relationships between the dams' breed and parity by using a commercially available vaginal temperature sensor in 72 Holstein (Hol) calvings and 101 Japanese Black (JB) calvings. Vaginal temperature sensors inserted 7-10 days before the expected calving day sounded two alerts: when the temperature fell below the threshold (Alert 1), and when the sensor reached the ambient temperature after falling out of the dam's vagina with the rupture of the allantoic sac (Alert 2). The durations from Alert 1 to Alert 2 (Time 1) and from Alert 2 to delivery (Time 2) were calculated. Read More

Acta Radiol 2022 Jul 7;63(7):976-981. Epub 2021 Jun 7.

Department of Medical Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

Background: Endometrioma is a common manifestation of endometriosis that can be difficult to diagnose with conventional magnetic resonance imaging (MRI). Susceptibility-weighted imaging (SWI) may be more sensitive than conventional MRI in the detection of chronic, local hemorrhagic disease.

Purpose: To investigate whether signal voids in SWI sequences could be used in the preoperative diagnosis of endometrioma. Read More

Postgrad Med J 2022 Jul 12;98(1161):e9. Epub 2021 Mar 12.

Gynaecology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia.

Background: Ruptured ovarian cysts are common gynaecological presentation to health institutions with abdominal pain. While this phenomenon is generally self-limiting, surgery may be necessary in cases of haemodynamic compromise or association with torsion. The aim of this audit is to identify the trend of hospital presentations, as well as the review the management of modern gynaecology practice. Read More

Am J Obstet Gynecol 2021 Jul 30;225(1):59.e1-59.e9. Epub 2021 Jan 30.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Observational retrospective data suggest that an artificial cycle frozen embryo transfer may be associated with a higher risk of hypertensive disorder of pregnancy than a natural cycle frozen embryo transfer among women with regular ovulatory cycles. The corpus luteum, which is not present in the artificial frozen cycles, is at least partly responsible for this poor obstetrical outcome. However, an artificial cycle is the most frequently used regimen for women with polycystic ovary syndrome undergoing frozen embryo transfer. Read More

Fertil Steril 2021 Apr 16;115(4):947-956. Epub 2021 Jan 16.

Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Objective: To investigate whether obstetric and perinatal outcomes in pregnancies differ after different frozen embryo transfer (FET) protocols.

Design: Register-based cohort study.

Setting: Not applicable. Read More

Turk J Obstet Gynecol 2020 Dec 10;17(4):300-309. Epub 2020 Dec 10.

Veris Delli Ponti Hospital, Chief of Clinic of Obstetrics and Gynecology, Scorrano, Lecce, Italy.

Hemorrhagic corpus luteum (HCL) is an ovarian cyst formed after ovulation and caused by spontaneous bleeding into a corpus luteum (CL) cyst. When HCL rupture happens, a hemoperitoneum results. Clinical symptoms are mainly due to peritoneal irritation by the blood effusion. Read More