297 results match your criteria Corpus Luteum Rupture


Minilaparotomic incision for haemorrhagic corpus luteum: a case report.

G Chir 2020 Jan-Feb;41(1):110-113

Corpus luteum cyst rupture with consequent hemoperitoneum is a common cause of admission to the emergency room. This condition is frequently misdiagnosed because of overlapping of clinical findings in acute gynecologic diseases. However, an incorrect identification may lead to delay in surgical treatment, which can Romabe a life-threatening condition. Read More

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February 2020

Thrombospondin 1 (THBS1) Promotes Follicular Angiogenesis, Luteinization, and Ovulation in Primates.

Front Endocrinol (Lausanne) 2019 7;10:727. Epub 2019 Nov 7.

Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, United States.

Angiogenesis is essential to both ovulation and the formation of the corpus luteum. The thrombospondin (THBS) family of glycoproteins plays diverse roles in regulation of angiogenesis, but the role of these vascular regulators in ovulation and luteinization remain to be elucidated. Using the cynomolgus macaque as a model for human ovulation, we demonstrated that levels of THBS1 mRNA and protein in preovulatory follicle granulosa cells increased after the ovulatory gonadotropin surge, with peak levels just before the expected time of ovulation. Read More

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http://dx.doi.org/10.3389/fendo.2019.00727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855263PMC
November 2019

MANAGEMENT OF RUPTURED CORPUS LUTEUM WITH HEMOPERITONEUM IN EARLY PREGNANCY - A CASE REPORT.

Acta Clin Croat 2018 Dec;57(4):785-788

1Rotunda IVF, Parnell Square, Dublin, Ireland; 2Department of Gynecology and Obstetrics, Sveti Duh University Hospital, Zagreb, Croatia.

- Rupture of the corpus luteum is a frequent condition in women of reproductive age. Because of abdominal pain accompanied by hemoperitoneum, ruptured corpus luteum can easily be confused with ectopic pregnancy. The management of ruptured corpus luteum depends on the symptoms and laboratory findings, and can be just observation but laparoscopy or urgent laparotomy may also be needed. Read More

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http://dx.doi.org/10.20471/acc.2018.57.04.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544092PMC
December 2018
25 Reads

Ultrasound classification and clinical analysis of ovarian pregnancy: A study of 12 cases.

J Gynecol Obstet Hum Reprod 2019 Nov 11;48(9):731-737. Epub 2019 Apr 11.

Department of Ultrasound, Qilu Hospital of Shandong University (Qingdao), Qingdao, China. Electronic address:

Objective: To evaluate the clinical significance of preoperative ultrasound diagnosis and classification of ovarian pregnancy (OP).

Methods: The ultrasonographic reports, medical records, and operative summaries were reviewed for twelve women with a confirmed diagnosis of OP. According to the ultrasonographic appearance, OP was classified into two types. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687847183045
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http://dx.doi.org/10.1016/j.jogoh.2019.04.003DOI Listing
November 2019
22 Reads

Pregnancy-Preserving Laparoscopic Treatment of Acute Hemoperitoneum Following Lutein Cyst Rupture in Early Gestation.

Authors:
Rafał Watrowski

Z Geburtshilfe Neonatol 2019 Apr 7;223(2):109-112. Epub 2019 Mar 7.

St. Josefskrankenhaus, Teaching Hospital of the University of Freiburg, Department of Gynecology and Obstetrics, Freiburg, Germany.

Acute hemoperitoneum (AHP) in early gestation is commonly treated via laparotomy. A ruptured corpus luteum (CL) cyst is a rare cause of AHP in pregnancy. This case report describes a 33-year-old, hemodynamically stable G2/P1 who presented at 5+5 gestational weeks with an acute abdomen due to ruptured CL cyst (7 cm). Read More

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http://dx.doi.org/10.1055/a-0853-8131DOI Listing
April 2019
11 Reads

Systematic Review of Ovarian Activity and Potential for Embryo Formation and Loss during the Use of Hormonal Contraception.

Linacre Q 2018 Nov 3;85(4):453-469. Epub 2019 Jan 3.

Saint Louis University, Saint Louis, MO, USA.

The purpose of this review was to determine whether there is evidence that ovulation can occur in women using hormonal contraceptives and whether these drugs might inhibit implantation. We performed a systematic review of the published English-language literature from 1990 to the present which included studies on the hormonal milieu following egg release in women using any hormonal contraceptive method. High circulating estrogens and progestins in the follicular phase appear to induce dysfunctional ovulation, where follicular rupture occurs but is followed by low or absent corpus luteum production of progesterone. Read More

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http://dx.doi.org/10.1177/0024363918815611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322118PMC
November 2018

Left-Right Asymmetry of Tubal Pregnancy: A 12-Year Retrospective Hospital-Based Study.

J Minim Invasive Gynecol 2019 May - Jun;26(4):671-678. Epub 2018 Jul 19.

Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China (Dr. Duan).. Electronic address:

Study Objective: To investigate whether there are left-right asymmetries, factors affecting lateral dominance, and clinical feature differences in the left and right sides of tubal pregnancy (TP).

Design: Retrospective study (Canadian Task Force classification II-2).

Setting: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University. Read More

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http://dx.doi.org/10.1016/j.jmig.2018.07.010DOI Listing
August 2019
39 Reads
1.575 Impact Factor

Coherent apoptotic and autophagic activities involved in regression of chicken postovulatory follicles.

Aging (Albany NY) 2018 04;10(4):819-832

Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.

After ovulation in mammals, rupture of mature follicles is reorganized into the corpus luteum that secrets progesterone (P) to stimulate endometrial development. The situation in birds differs considerably. Beyond ovulation the ruptured avian follicle forms a postovulatory follicle (POF) that is not considered analogous to mammalian corpus luteum. Read More

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http://dx.doi.org/10.18632/aging.101436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940126PMC
April 2018
22 Reads

Imaging the ovary.

Reprod Biomed Online 2018 May 6;36(5):584-593. Epub 2018 Mar 6.

Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address:

During each reproductive cycle, the ovary exhibits tissue remodelling and cyclic vasculature changes associated with hormonally regulated folliculogenesis, follicle rupture, luteal formation and regression. However, the relationships among different types of follicles and corpora lutea are unclear, and the role of ovarian vasculature in folliculogenesis and luteal dynamics has not been extensively investigated. Understanding of ovarian physiology and pathophysiology relies upon elucidation of ovarian morphology and architecture. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.02.006DOI Listing
May 2018
17 Reads

[α1-antitrypsin Pittsburg mutations: report of two cases in the same family].

Zhonghua Xue Ye Xue Za Zhi 2017 Nov;38(11):968-971

Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

To analyze the clinical and laboratory abnormalities of two patients with α1-antitrypsin (α1-AT) Pittsburgh in a family and review the literatures. Both plasma clotting time and factor activities were performed using clotting or substrate methods. Platelet aggregation was evaluated using an optical aggregometer. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2017.11.014DOI Listing
November 2017
10 Reads

Placental Growth Factor Is Required for Ovulation, Luteinization, and Angiogenesis in Primate Ovulatory Follicles.

Endocrinology 2018 02;159(2):710-722

Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia.

Placental growth factor (PGF) is member of the vascular endothelial growth factor (VEGF) family of angiogenesis regulators. VEGFA is an established regulator of ovulation and formation of the corpus luteum. To determine whether PGF also mediates aspects of ovulation and luteinization, macaques received gonadotropins to stimulate multiple follicular development. Read More

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http://academic.oup.com/endo/article/159/2/710/4582237
Publisher Site
http://dx.doi.org/10.1210/en.2017-00739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774250PMC
February 2018
18 Reads

Ruptured Corpus Luteal Cyst: Prediction of Clinical Outcomes with CT.

Korean J Radiol 2017 Jul-Aug;18(4):607-614. Epub 2017 May 19.

Department of Obstetrics and Gynecology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea.

Objective: To evaluate the determinant pretreatment CT findings that can predict surgical intervention for patients suffering from corpus luteal cyst rupture with hemoperitoneum.

Materials And Methods: From January 2009 to December 2014, a total of 106 female patients (mean age, 26.1 years; range, 17-44 years) who visited the emergency room of our institute for acute abdominal pain and were subsequently diagnosed with ruptured corpus luteal cyst with hemoperitoneum were included in the retrospective study. Read More

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http://dx.doi.org/10.3348/kjr.2017.18.4.607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447636PMC
October 2017
72 Reads

Possible role of PPARγ in the negative regulation of ovulatory cascade and luteal development in rats.

J Vet Med Sci 2017 Jun 19;79(6):1043-1051. Epub 2017 May 19.

Laboratory of Veterinary Physiology, Kitasato University School of Veterinary Medicine, Towada, Aomori 034-8628, Japan.

Peroxisome proliferator-activated receptor γ (PPARγ), a member of a nuclear receptor family, has been shown to be implicated in various reproductive processes. Here, we evaluated possible roles of PPARγ in ovulation and luteal development in a gonadotropins-primed immature rat model. Immunoreactive PPARγ was expressed in granulosa cells of eCG-stimulated mature follicles, and its expression level decreased following ovulatory hCG stimulus. Read More

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http://dx.doi.org/10.1292/jvms.17-0162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487780PMC
June 2017
11 Reads

A novel nonsense NBEAL2 gene mutation causing severe bleeding in a patient with gray platelet syndrome.

Platelets 2018 May 15;29(3):288-291. Epub 2017 May 15.

a Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health , The First Affiliated Hospital of Soochow University , Suzhou , China.

Gray platelet syndrome (GPS) is a rare, inherited bleeding disorder characterized by the defect of platelet α-granule. Up to date, these are only four studies identifying NBEAL2 gene correlated with GPS. In the current report, we present a Chinese GPS patient who had severe bleeding tendency, abnormalities of platelet functions, and absence of platelet α-granules. Read More

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http://dx.doi.org/10.1080/09537104.2017.1306041DOI Listing
May 2018
136 Reads

Induction of Tissue Factor Pathway Inhibitor 2 by hCG Regulates Periovulatory Gene Expression and Plasmin Activity.

Endocrinology 2017 01;158(1):109-120

Department of Obstetrics and Gynecology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536; and.

Increased proteolytic activity is a key event that aids in breakdown of the follicular wall to permit oocyte release. How the protease activity is regulated is still unknown. We hypothesize that tissue factor pathway inhibitor 2 (TFPI2), a Kunitz-type serine protease inhibitor, plays a role in regulating periovulatory proteolytic activity as in other tissues. Read More

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http://dx.doi.org/10.1210/en.2016-1544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412983PMC
January 2017
14 Reads

Knockdown of Progesterone Receptor (PGR) in Macaque Granulosa Cells Disrupts Ovulation and Progesterone Production.

Biol Reprod 2016 05 16;94(5):109. Epub 2016 Mar 16.

Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.

Adenoviral vectors (vectors) expressing short-hairpin RNAs complementary to macaque nuclear progesterone (P) receptor PGR mRNA (shPGR) or a nontargeting scrambled control (shScram) were used to determine the role PGR plays in ovulation/luteinization in rhesus monkeys. Nonluteinized granulosa cells collected from monkeys (n = 4) undergoing controlled ovarian stimulation protocols were exposed to either shPGR, shScram, or no virus for 24 h; human chorionic gonadotropin (hCG) was then added to half of the wells to induce luteinization (luteinized granulosa cells [LGCs]; n = 4-6 wells/treatment/monkey). Cells/media were collected 48, 72, and 120 h postvector for evaluation of PGR mRNA and P levels. Read More

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http://dx.doi.org/10.1095/biolreprod.115.134981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939739PMC
May 2016
79 Reads

PDGFR Inhibition Results in Pericyte Depletion and Hemorrhage into the Corpus Luteum of the Rat Ovary.

Toxicol Pathol 2016 Jan 3;44(1):98-111. Epub 2015 Nov 3.

AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire, UK.

The growth plate, ovary, adrenal gland, and rodent incisor tooth are sentinel organs for antiangiogenic effects since they respond reliably, quantitatively, and sensitively to inhibition of the vascular endothelial growth factor receptor (VEGFR). Here we report that treatment of rats with platelet-derived growth factor receptor beta (PDGFRβ) inhibitors that target pericytes results in severe ovarian hemorrhage with degeneration and eventual rupture of the corpus luteum. Evaluation of the growth plate, adrenal gland, and incisor tooth that are typical target organs for antiangiogenic treatment in the rodent revealed no abnormalities. Read More

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http://dx.doi.org/10.1177/0192623315613452DOI Listing
January 2016
71 Reads

A Huge Mature Cystic Teratoma in a Nulliparous Patient.

J Clin Diagn Res 2015 Sep 1;9(9):QD03-4. Epub 2015 Sep 1.

Faculty, Department of Obstetrics and Gynecology, Acibadem Hospital , Bakirkoy/Istanbul .

Here we report a case of a giant mature cystic teratoma of the ovary in a 38-year-old nullipaous woman. The patient presented with abdominal distension and abdominal pain. Laparotomy and cystectomy yielded satisfactory results. Read More

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http://dx.doi.org/10.7860/JCDR/2015/14158.6418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606291PMC
September 2015
58 Reads

A Follicle Rupture Assay Reveals an Essential Role for Follicular Adrenergic Signaling in Drosophila Ovulation.

PLoS Genet 2015 Oct 16;11(10):e1005604. Epub 2015 Oct 16.

Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, United States of America; Institute for Systems Genomics, University of Connecticut, Storrs, Connecticut, United States of America.

Ovulation is essential for the propagation of the species and involves a proteolytic degradation of the follicle wall for the release of the fertilizable oocyte. However, the precise mechanisms for regulating these proteolytic events are largely unknown. Work from our lab and others have shown that there are several parallels between Drosophila and mammalian ovulation at both the cellular and molecular levels. Read More

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http://dx.doi.org/10.1371/journal.pgen.1005604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608792PMC
October 2015
21 Reads

Massive hemoperitoneum due to a ruptured corpus luteum cyst in a patient with congenital hypofibrinogenemia.

Obstet Gynecol Sci 2015 Sep 22;58(5):427-30. Epub 2015 Sep 22.

Department of Obstetrics and Gynecology, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Korea.

Congenital afibrinogenemia/hypofibrinogenemia is a rare inherited hematologic disorder in which a patient lacks or has insufficient level of fibrinogen, the blood coagulation factor I. The incidence of this uncommon disease is 1 to 2 per 1 million individuals. Hence, massive hemoperitoneum caused by ovulation in a woman with congenital afibrogenemia is also a very rare clinical condition. Read More

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http://dx.doi.org/10.5468/ogs.2015.58.5.427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588852PMC
September 2015
20 Reads

A prospective, randomized, pharmacodynamic study of quick-starting a desogestrel progestin-only pill following ulipristal acetate for emergency contraception.

Hum Reprod 2015 Dec 23;30(12):2785-93. Epub 2015 Sep 23.

Dinox, Hanzeplein 1, Entrance 53, Groningen 9713 GZ, The Netherlands.

Study Question: Is there a pharmacodynamic interaction between ulipristal acetate (UPA) 30 mg for emergency contraception and a daily progestin-only contraceptive pill, desogestrel (DSG) 0.75 mg, when initiated the next day?

Summary Answer: In this study, DSG impaired the ability of UPA to delay ovulation, but UPA had little impact on the onset of contraceptive effects due to DSG.

What Is Known Already: UPA is a progesterone receptor modulator used for emergency contraceptive (EC) at the dose of 30 mg. Read More

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http://humrep.oxfordjournals.org/content/early/2015/09/23/hu
Web Search
http://humrep.oxfordjournals.org/lookup/doi/10.1093/humrep/d
Publisher Site
http://dx.doi.org/10.1093/humrep/dev241DOI Listing
December 2015
18 Reads

Ruptured Hemorrhagic Corpus Luteum Cyst in an Undescended Ovary: A Rare Cause of Acute Abdomen.

J Pediatr Adolesc Gynecol 2016 Feb 25;29(1):e21-4. Epub 2015 Sep 25.

Department of Obstetrics and Gynecology, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Background: Undescended ovaries are typically detected during infertility evaluations and are frequently associated with uterine malformations. Ruptured hemorrhagic corpus luteum cyst of an undescended ovary is an unusual cause of acute abdomen in an adolescent.

Case: A 15-year-old girl presented with right lower quadrant pain, nausea, and vomiting, and transabdominal sonography and magnetic resonance imaging of the pelvis showed a 10 cm × 5 cm sized cystic mass at the level of the pelvic brim, anterior to the psoas muscle suggestive of a retroperitoneal hemorrhagic cyst. Read More

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http://dx.doi.org/10.1016/j.jpag.2015.09.004DOI Listing
February 2016
22 Reads

Diagnostic dilemma in ovarian pregnancy: a case series.

J Clin Diagn Res 2015 Apr 1;9(4):QR01-3. Epub 2015 Apr 1.

Associate Professor, Department of Obstetrics and Gynecology, Mahatama Gandhi Medical College and Research Institute , Puducherry, India .

Ovarian pregnancy is a rare form of ectopic pregnancy but it is the most common type of nontubal ectopic pregnancy. Many times it is operated with a misdiagnosis of ruptured tubal ectopic pregnancy or hemorrhagic corpus luteum. The high resolution transvaginal ultrasonography is a valuable tool for diagnosis of ectopic pregnancy but ovarian pregnancy still remains a diagnostic problem and a continuous challenge to the gynecologist. Read More

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http://dx.doi.org/10.7860/JCDR/2015/11501.5772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437125PMC
April 2015
21 Reads

Hemoperitoneum from corpus luteum rupture in patients with aplastic anemia.

Clin Lab 2015 ;61(3-4):427-30

Background: Aplastic anemia is a rare hematopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow. Women with aplastic anemia usually are at increased risk of corpus luteum rupture due to thrombocytopenia and infection.

Methods: Here we report two cases had hemoperitoneum from corpus luteum rupture in patients with aplastic anemia in our center. Read More

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http://dx.doi.org/10.7754/clin.lab.2014.141010DOI Listing
June 2015
19 Reads

Successful diagnosis and laparoscopic management of haemorrhagic ovarian pregnancy with haemorrhagic contralateral corpus luteum.

Aust N Z J Obstet Gynaecol 2015 Apr 27;55(2):191-2. Epub 2015 Apr 27.

Department of Obstetrics and Gynaecology, Mater Mothers' Hospital, Brisbane, Qld, Australia.

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http://doi.wiley.com/10.1111/ajo.12307
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http://dx.doi.org/10.1111/ajo.12307DOI Listing
April 2015
14 Reads

Recurrent massive haemoperitoneum associated with ruptured corpus luteum in women with congenital afibrinogenemia; case report.

Turk J Obstet Gynecol 2014 Dec 15;11(4):242-245. Epub 2014 Dec 15.

Ankara Numune Education and Research Hospital, Clinic of Gynecology and Obstetrics, Ankara, Turkey.

Massive hemoperitoneum secondary to ruptured corpus luteum is a rare but serious and life-threatening complication for women with congenital bleeding disorders and may lead to surgical interventions and even oophorectomy. Congenital afibrinogenemia is a rare inherited coagulation disorder. As it can be asymptomatic, its clinical manifestations vary from minimal tendency of bleeding to life-threatening bleedings. Read More

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http://dx.doi.org/10.4274/tjod.04935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558369PMC
December 2014
18 Reads

Hemoperitoneum from corpus luteal cyst rupture: a practical approach in emergency room.

Case Rep Emerg Med 2014 1;2014:252657. Epub 2014 Jun 1.

Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiation Therapy, University Hospital Tor Vergata, Viale Oxford, 81-00133 Rome, Italy.

Corpus luteum cyst rupture with consequent hemoperitoneum is a common disorder in women in their reproductive age. This condition should be promptly recognized and treated because a delayed diagnosis may significantly reduce women's fertility and intra-abdominal bleeding may be life-threatening. Many imaging modalities play a key role in the diagnosis of acute pelvic pain from gynecological causes. Read More

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http://dx.doi.org/10.1155/2014/252657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058584PMC
July 2014
33 Reads

Mathematical analysis of a model for the growth of the bovine corpus luteum.

J Math Biol 2014 Dec 13;69(6-7):1515-46. Epub 2013 Dec 13.

School of Biosciences, University of Nottingham, Loughborough, LE12 5RD, UK,

The corpus luteum (CL) is an ovarian tissue that grows in the wound space created by follicular rupture. It produces the progesterone needed in the uterus to maintain pregnancy. Rapid growth of the CL and progesterone transport to the uterus require angiogenesis, the creation of new blood vessels from pre-existing ones, a process which is regulated by proteins that include fibroblast growth factor 2 (FGF2). Read More

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http://eprints.maths.ox.ac.uk/1681/1/finalOR09.pdf
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http://link.springer.com/content/pdf/10.1007%2Fs00285-013-07
Web Search
http://link.springer.com/10.1007/s00285-013-0722-2
Publisher Site
http://dx.doi.org/10.1007/s00285-013-0722-2DOI Listing
December 2014
16 Reads

[Complications of presumed benign ovarian tumors].

J Gynecol Obstet Biol Reprod (Paris) 2013 Dec 7;42(8):816-32. Epub 2013 Nov 7.

Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Antoine-Béclère, AP-HP, 157, rue de la Porte-de-Trivaux, 92140 Clamart, France; Faculté de médecine, université Paris-Sud, 91405 Orsay, France. Electronic address:

The main risk factor of adnexal torsion is a previous adnexal torsion (LE3). There is no clinical, biological or radiological sign that may exclude the diagnosis of adnexal torsion (LE3). The presence of flow at color Doppler imaging does not allow exclusion of the diagnosis (LE2). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03682315130028
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http://dx.doi.org/10.1016/j.jgyn.2013.09.036DOI Listing
December 2013
15 Reads

Follicle growth, ovulation, and luteal formation in primates and rodents: a comparative perspective.

Exp Biol Med (Maywood) 2013 May;238(5):539-48

Department of OB/GYN & Reproductive Sciences, University of Maryland Baltimore, Baltimore, MD, USA.

Ovarian function has a great deal of functional overlap between species; antral follicles grow in response to FSH, ovulation involves proteolysis, and the steroidogenic pathway is largely the same. However, embedded in these similarities are important differences that reflect the evolutionary and natural history of species and may focus future research into these critical areas. This review compares ovarian function of rats and mice with primates, focusing on estradiol and follicle growth, steroidogenesis and rupture during the periovulatory interval, and the formation of a functional corpus luteum, drawing the conclusion that careful comparison of species yields more functional information about both than studying them in isolation. Read More

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http://dx.doi.org/10.1177/1535370213489437DOI Listing
May 2013
26 Reads

Genetic associations of relaxin: preterm birth and premature rupture of fetal membranes.

Am J Obstet Gynecol 2013 Sep 10;209(3):258.e1-8. Epub 2013 May 10.

Department of Obstetrics, Gynecology, and Women's Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.

Objective: Relaxin H2 (RLN2) is a systemic hormone (sRLN) that is produced by the corpus luteum, whereas decidual RLN (dRLN) acts only locally. Elevated sRLN is associated with spontaneous preterm birth (sPTB) and elevated dRLN with preterm premature rupture of membranes (PPROM). Associations were sought between single nucleotide polymorphisms (SNPs) in the RLN2 promoter with levels of dRLN and sRLN in Filipino patients with sPTB, PPROM, or normal term delivery. Read More

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http://dx.doi.org/10.1016/j.ajog.2013.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758420PMC
September 2013
51 Reads

Small-platelet thrombocytopenia in a family with autosomal recessive inheritance pattern.

Pediatr Blood Cancer 2013 Oct 6;60(10):E128-30. Epub 2013 May 6.

Pediatric Hematology Unit and Pediatric Department B, Emek Medical Center, Afula, Israel.

We describe the clinical and laboratory features of a family of Arab ancestry and consanguinity. Five affected individuals were diagnosed in two sibships. All affected members have small platelets, severe to moderate thrombocytopenia of neonatal onset, increased bleeding tendency and bleeding complications such as: life-threatening massive hemoperitoneum due to corpus luteum rupture during ovulation and severe mucosal bleeding. Read More

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http://dx.doi.org/10.1002/pbc.24581DOI Listing
October 2013
39 Reads

Life-long oral anticoagulant therapy and rupture of corpus luteum.

Anadolu Kardiyol Derg 2013 Jun 22;13(4):407-8. Epub 2013 Apr 22.

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http://dx.doi.org/10.5152/akd.2013.123DOI Listing
June 2013
17 Reads

Conservative management of massive hematoperitoneum caused by ovulation in a patient with severe form of von Willebrand disease--a case report.

Clin Exp Obstet Gynecol 2012 ;39(4):537-40

Department of Gynaecology and Obstetrics, University of Belgrade, Faculty of Medicine, Belgrade, Serbia.

Von Willebrand disease (VWD) is the most common inherited bleeding condition that involves extended or excessive bleeding, caused by the deficiency or defect of von Willebrand factor (VWF). Hematoperitoneum as a complication of gynecologic diseases represents acute condition which is usually caused by the hemorrhagic corpus luteum or a rupture of either ectopic pregnancy or a hemorrhagic ovarian cyst. The authors present a unique case of conservatively managed massive hematoperitoneum caused by ovulation in a patient with severe form of von Willebrand disease who had right adnexectomy due to hemorrhagic corpus luteum four months prior. Read More

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March 2013
17 Reads

Emergency contraception -- mechanisms of action.

Contraception 2013 Mar 29;87(3):300-8. Epub 2012 Oct 29.

Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet/ Karolinska University Hospital, S-171 76 Stockholm, Sweden.

Concerns regarding the mechanisms of action of emergency contraception (EC) create major barriers to widespread use and could also lead to incorrect use of EC and overestimation of its effectiveness. While the copper intrauterine device (Cu-IUD) is the most effective method available for EC, the hormonal methods are frequently considered to be more convenient and acceptable. Today, the most commonly used method for hormonal EC is levonorgestrel (LNG). Read More

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http://dx.doi.org/10.1016/j.contraception.2012.08.021DOI Listing
March 2013
21 Reads

Relationships between the luteinizing hormone surge and other characteristics of the menstrual cycle in normally ovulating women.

Fertil Steril 2013 Jan 19;99(1):279-85. Epub 2012 Sep 19.

Service de Biostatistique, Hospices Civils de Lyon, Lyon, France.

Objective: To describe the LH surge variants in ovulating women and analyze their relationship with the day of ovulation and other hormone levels.

Design: Secondary analysis of a prospective cohort observational study.

Setting: Eight natural family planning clinics. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2012.08.047DOI Listing
January 2013
17 Reads

Giant abdominopelvic haematoma arising from ovulation in a Glanzmann's thrombasthenia patient with platelet refractoriness: treatment with surgery and intra-abdominal tranexamic acid.

Acta Haematol 2012 10;128(3):154-7. Epub 2012 Aug 10.

Hematology Unit, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Glanzmann's thrombasthenia (GT) is a very rare autosomal recessive genetic bleeding disorder. Women with coagulation abnormalities are at increased risk of corpus luteum rupture and haemoperitoneum. Here we present a severe case of GT resulting in a haematoma extending from the pelvis to the liver that could only be controlled by surgery and intra-abdominal tranexamic acid. Read More

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http://dx.doi.org/10.1159/000339085DOI Listing
December 2012
12 Reads

Heterotopic pregnancy following intrauterine insemination: successful management with salpingectomy and continuation of intrauterine pregnancy.

Niger J Clin Pract 2012 Apr-Jun;15(2):241-3

Department of Obstetrics/Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi Anambra State, Nigeria.

We report the first case of a heterotopic pregnancy (HP) following ovulation induction and intrauterine insemination (IUI) with resultant normal intrauterine pregnancy after salpingectomy. A 41-year-old para 0 +0 that presented with primary infertility due to azoospermia and polycystic ovaries after laparoscopic evaluation. She had induction of ovulation with Clomiphene citrate, gonadotropin stimulation (hCG), and intrauterine insemination using donor sperm. Read More

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http://www.njcponline.com/text.asp?2012/15/2/241/97338
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http://dx.doi.org/10.4103/1119-3077.97338DOI Listing
October 2012
17 Reads

Why two endothelins and two receptors for ovulation and luteal regulation?

Life Sci 2012 Oct 4;91(13-14):501-6. Epub 2012 Jun 4.

Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urnana, IL 61802, USA.

The ovary is a dynamic organ that undergoes cyclic structural and functional changes. Structurally, the internal architecture of the ovary constantly changes as follicles grow, rupture and transform into corpora lutea in a cyclical manner. Functionally, a variety of regulatory ovarian hormones are sequentially produced, and eggs are periodically released. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205120028
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http://dx.doi.org/10.1016/j.lfs.2012.05.010DOI Listing
October 2012
22 Reads

Relaxin augments the inflammatory IL6 response in the choriodecidua.

Placenta 2012 May 3;33(5):399-407. Epub 2012 Mar 3.

Department of Cell and Molecular Biology, University of Hawaii, John A. Burns School of Medicine, 651 Ilalo Street, Bioscience Building, Honolulu, HI 96813, USA.

Unlabelled: Intrauterine infection frequently leads to preterm birth (PTB), with the pathophysiology involving activation of the innate immune system and its associated inflammatory response. The choriodecidua produces relaxin (RLN) and elevated levels are associated with preterm premature rupture of the fetal membranes. However, it is not increased in bacterially-mediated PTB, but may act as an endogenous sterile inflammatory mediator. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01434004120007
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http://dx.doi.org/10.1016/j.placenta.2012.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319264PMC
May 2012
12 Reads

Contraception by induction of luteinized unruptured follicles with short-acting low molecular weight FSH receptor agonists in female animal models.

Reproduction 2011 Dec 19;142(6):893-905. Epub 2011 Sep 19.

Merck Research Laboratories, Department of Women's Health, Oss, The Netherlands.

During recent decades minor innovative drugs have been developed for the female contraceptive market and they all contain steroidal progestagens (and estrogens) that act centrally and have side effects that can be attributed to this central action. In this study, we present an innovative tissue-specific approach for female contraception by low molecular weight (LMW) FSH receptor (FSHR) agonists, which interact with the FSHR that is dominantly expressed in the granulosa cells. The oral administration of LMW FSHR agonists with a short circulation time, induced formation of luteinized unruptured follicles (LUFs) from the Graafian follicles, thereby preventing the release of the oocyte. Read More

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https://rep.bioscientifica.com/view/journals/rep/142/6/893.x
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http://dx.doi.org/10.1530/REP-11-0234DOI Listing
December 2011
10 Reads

Laparoscopic management of pregnancy in a patient with uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis.

J Minim Invasive Gynecol 2011 May-Jun;18(3):381-5

Department of Gynecology, Obstetrics, and Women's Health, Henry Ford Hospital, Detroit, Michigan 48202, USA.

Pregnancy in a rudimentary uterine horn is a rare and potentially lethal condition. The highest risk of rupture is reported to be during the late first and second trimester. The risk of rupture correlates with the thickness of the myometrium surrounding the fetal pole. Read More

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http://dx.doi.org/10.1016/j.jmig.2011.01.005DOI Listing
October 2011
15 Reads

Ovarian surface epitheliectomy in the non-human primate: continued cyclic ovarian function and limited epithelial replacement.

Hum Reprod 2011 Jun 18;26(6):1422-30. Epub 2011 Mar 18.

Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA.

Background: The fifth leading cause of cancer deaths among women is ovarian cancer (OC), which originates primarily in the ovarian surface epithelium (OSE) that surrounds the ovary. Permanent removal of the OSE could provide a novel strategy to substantially reduce OC risk, while retaining the benefits of ovarian function, including gameto- and steroidogenesis. It must be determined whether ovarian surface epitheliectomy (OSEx) carries deleterious side effects, including loss of menstrual cyclicity, infertility or scarring (e. Read More

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https://academic.oup.com/humrep/article-lookup/doi/10.1093/h
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http://dx.doi.org/10.1093/humrep/der061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096558PMC
June 2011
15 Reads

The water permeability channels aquaporins 1-4 are differentially expressed in granulosa and theca cells of the preovulatory follicle during precise stages of human ovulation.

J Clin Endocrinol Metab 2011 Apr 20;96(4):1021-8. Epub 2011 Jan 20.

Department of Obstetrics and Gynaecology, Sahlgrenska Academy, University of Gothenburg, SE-413 45 Göteborg, Sweden.

Context: Changes in vascular permeability and expansion of the fluid-filled antrum are major events in the LH-induced ovulatory process.

Objectives: Our objective was to investigate the presence and expression levels of aquaporins (AQPs) in the granulosa and theca cell compartments of the follicle during defined phases of human ovulation.

Design And Setting: We conducted a prospective experimental study at the Department of Obstetrics and Gynaecology at a university hospital. Read More

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http://dx.doi.org/10.1210/jc.2010-2545DOI Listing
April 2011
17 Reads

Recurrent massive hemoperitoneum due to ovulation as a clinical sign in congenital afibrinogenemia.

Acta Obstet Gynecol Scand 2011 Feb 29;90(2):192-4. Epub 2010 Nov 29.

Department of Obstetrics and Gynecology, Ankara University Medical Faculty, Ankara, Turkey.

Massive hemoperitoneum due to ovulation is a rare but serious and life-threatening complication for women with coagulation disorders, and may lead to surgical interventions and even oophorectomy. Congenital afibrinogenemia is an uncommon coagulation disorder usually discovered during childhood. Intraabdominal bleeding due to ovulation is very rare in these patients and only a few cases of corpus luteum rupture and hemoperitoneum in afibrinogenemic patients have been described. Read More

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http://dx.doi.org/10.1111/j.1600-0412.2010.01034.xDOI Listing
February 2011
17 Reads

Footmarks of innate immunity in the ovary and cytokeratin-positive cells as potential dendritic cells.

Adv Anat Embryol Cell Biol 2011 ;209:vii-99

Institute of Anatomy, University of Leipzig, Leipzig, Germany.

This monograph introduces innate immunity as a second force in the ovary in addition to the endocrine system. Innate immunity appears to orchestrate follicular atresia, follicle rupture, and follicle transformation into a corpus luteum (CL) and CL regression through sterile inflammation and tissue repair. The concept is new. Read More

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http://dx.doi.org/10.1007/978-3-642-16077-6DOI Listing
January 2011
9 Reads

A rare case report: ovarian heterotopic pregnancy after in vitro fertilization.

Fertil Steril 2010 Oct 1;94(5):1910.e9-11. Epub 2010 Apr 1.

Reproductive Medicine Unit, Christian Medical College Hospital, Vellore, India.

Objective: To report a case of ovarian heterotopic pregnancy after an IVF cycle.

Design: Case report.

Setting: Reproductive medicine unit, Christian Medical College Hospital, Vellore, India. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2010.02.045DOI Listing
October 2010
34 Reads

Toxic effects of cypermethrin and methamidophos on bovine corpus luteal cells and progesterone production.

Exp Toxicol Pathol 2011 Jan 25;63(1-2):131-5. Epub 2009 Nov 25.

Department of Veterinary Pathology, University of Agriculture, Faisalabad-38040, Pakistan.

This study was planned and executed with the aims to explore corpus luteal primary cell culture as an "animal alternate testing system" in toxicity studies and in vitro toxic effects of cypermethrin (CY) 90% (pyrethroid) and methamidophos (MTP) 73% (organophosphate) on morphology and progesterone secretory activity of bovine corpus luteal cells and tissue. For this purpose, primary cell cultures of bovine corpus luteum (CL) cells were maintained in Dulbecco's Modified Eagle Medium (DMEM) supplemented with 5% fetal calf serum (FCS). Toxicity evaluation were based on viable CL cell counts, morphological changes in CL cells, ability of CL cells to produce progesterone and histological changes in CL tissue at different hours post exposure to CY and MTP. Read More

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http://dx.doi.org/10.1016/j.etp.2009.10.007DOI Listing
January 2011
14 Reads

Hypoxia is important for establishing vascularization during corpus luteum formation in cattle.

J Reprod Dev 2010 Feb 2;56(1):110-6. Epub 2009 Nov 2.

Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Japan.

Hypoxia-inducible factor 1 (HIF1) has been demonstrated to have critical roles in angiogenesis via transcriptional regulation of angiogenic factors, such as vascular endothelial growth factor (VEGF). In the ovary, angiogenesis is known to occur after ovulation in the developing corpus luteum (CL) in mammals. To determine whether HIF1 participates in angiogenesis in bovine CL, the present study investigated the mRNA and protein expressions of the HIF1 alpha subunit (HIF1A) and VEGF in bovine CL during the estrous cycle. Read More

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http://dx.doi.org/10.1262/jrd.09-162eDOI Listing
February 2010
15 Reads