5,809 results match your criteria Coronary Artery Vasospasm


Chest pain caused by left coronary artery spasm in a patient with anomalous origin of right coronary artery.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 May;47(5):679-684

Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Anomalous origin of coronary artery is rare and important reason of chest pain, syncope, and sudden death in young and middle-aged patients. This case reported a patient with interarterial anomalous right coronary artery and chest pain, which was confirmed to be the result of severe vasospasm of the proximal left anterior descending artery. The patient had reoccurred spontaneous chest pain and the dynamic ST segment and T wave changes at anterior walls. Read More

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Clonidine Overdose as an Unusual Cause of Heart Failure.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221106856

Kern Medical Center, Bakersfield, CA, USA.

Clonidine is used as an antihypertensive medication due to its effect on decreasing peripheral vascular resistance and therefore lowering blood pressure. Alpha antagonism in the medulla and the posterior hypothalamus causing a reduction in sympathetic activation allows for clonidine to be used as an effective off-label treatment for attention-deficit/hyperactivity disorder (ADHD). This is a case of a 28-year-old female with hypertension, ADHD, and depression who developed acute heart failure with significant troponemia after ingesting 30 pills of clonidine. Read More

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A Case Report of Severe Dehydration Associated With Acute Kidney Injury Causing Acute ST-Segment Elevation Myocardial Infarction.

Cureus 2022 May 22;14(5):e25226. Epub 2022 May 22.

Cardiology Department, Dubai Hospital, Dubai Health Authority, Dubai, ARE.

The initial electrocardiogram finding in the setting of acute myocardial infarction typically shows either persistent ST-segment elevation or non-ST-segment elevation. In young adults, when coronary angiography is performed, can further classify the patient with an occluded vessel and those with non-occluded coronary arteries. In these subgroups, myocardial infarction can be explained on the basis of coronary artery thrombosis, embolization, spontaneous coronary artery dissection, myocardial bridging, coronary aneurysms, ectasia, anomalous origin of coronary arteries coronary microvascular dysfunction, and vasospasm, or a combination of these factors. Read More

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Coronary Vasospasm Associated With Synthetic Marijuana Resulting in Transient Electrocardiogram Changes and Troponin Elevation.

Cureus 2022 May 17;14(5):e25084. Epub 2022 May 17.

Emergency Medicine, Southeast Health Medical Center, Dothan, USA.

Chest pain is a common presentation in the emergency department requiring prompt evaluation and risk stratification to assess for acute coronary syndrome versus non-cardiac causes. In the past, cocaine has been documented to be associated with the presentation of acute myocardial infarction. This case report describes a rare case of coronary vasospasm with transient electrocardiogram (EKG) changes and significantly elevated troponin in an individual presenting with a recent history of synthetic marijuana use. Read More

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Inhibitory mechanism of tangeretin, a citrus flavone on the sphingosylphosphorylcholine (SPC)-induced vascular smooth muscle contraction.

J Pharmacol Sci 2022 Aug 13;149(4):189-197. Epub 2022 May 13.

Department of Advanced Preventive Medicine, School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, 755-8505, Japan. Electronic address:

We previously discovered that the SPC/Fyn/Rho-kinase (ROK) pathway mediates the Ca-sensitization of coronary arterial smooth muscle (CASM) contraction leading to vasospasm, a major cause of sudden death. Lately, we have been trying to find and develop more natural edible compounds which can treat and/or prevent the SPC-induced abnormal CASM contraction, and finally the first to discover that tangeretin (5,6,7,8,4'-pentamethoxyflavone), a natural compound extracted from citrus plants, can inhibit the SPC-induced CASM contraction both in the pretreatment and posttreatment. In porcine CASM tissues, tangeretin showed remarkable inhibitory effects on the SPC-induced contraction with modest inhibitory effects on the high K-depolarization-induced Ca-dependent contraction, both in pretreatment and posttreatment at the optimal concentrations; Regarding the mechanisms, tangeretin markedly abolished the SPC-induced cell contraction through inhibiting the SPC-induced activation and translocation of Fyn and ROK from the cytoplasm to the cell membrane in cultured CASM cells, resulting in the reduction of phosphorylation of myosin light chain. Read More

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Beyond Structural Angiography: The Emergence of Functional Coronary Angiography.

J Am Coll Cardiol 2022 Jun;79(24):2379-2382

Discipline of Medicine, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Central Adelaide Local Health Network, Adelaide, South Australia, Australia; Basil Hetzel Institute for Translational Health Research, Adelaide, South Australia, Australia.

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Safety of Provocative Testing With Intracoronary Acetylcholine and Implications for Standard Protocols.

J Am Coll Cardiol 2022 Jun;79(24):2367-2378

Division of Cardiology, NewYork-Presbyterian Brooklyn Methodist Hospital, Weill Cornell Medicine, Brooklyn, New York, USA. Electronic address:

Background: Heterogeneity in diagnostic criteria and provocation protocols has posed challenges in understanding the safety of coronary provocation testing with intracoronary acetylcholine (ACh) for the contemporary diagnosis of epicardial and microvascular spasm.

Objectives: We examined the safety of testing and subgroup differences in procedural risks based on ethnicity, diagnostic criteria, and provocation protocols.

Methods: PubMed and Embase were searched in November 2021 to identify original articles reporting procedural complications associated with intracoronary ACh administration. Read More

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Does Coronary Vasospasm Show a Better Prognosis in Out of Hospital Cardiac Arrest: Data from the Korean Cardiac Arrest Research Consortium (KoCARC) Registry.

Anatol J Cardiol 2022 06;26(6):450-459

Department of Internal Medicine, Division of Cardiology, Sejong General Hospital, Seoul, Korea.

Background: Previous cohort studies focused on relative risk stratification among patients diagnosed with vasospastic angina, and it is unknown how much vasospasm accounts for the cause of out-of-hospital cardiac arrest, and whether prognosis differs.

Methods: From a registry data collected from 65 hospitals in Korea, 863 subjects who survived hospital cardiac arrest were evaluated. The patients with insignificant coro- nary lesion, vasospasm, and obstructive lesion were each grouped as group I, group II, and group III, respectively. Read More

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Increased plasma glutamate in non-smokers with vasospastic angina pectoris is associated with plasma cystine and antioxidant capacity.

Scand Cardiovasc J 2022 Dec;56(1):180-186

Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan.

. Endothelial dysfunction caused by oxidative stress plays an important role in the development of vasospastic angina pectoris (VSAP). Glutamate causes endothelial dysfunction by generating oxidative stress, and it inhibits cystine import into endothelial cells via the cystine/glutamate antiporter (X), which leads to depletion of antioxidant glutathione. Read More

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December 2022

Complete anatomic surgical myocardial revascularisation during postinfarction ventricular septal defect and ventricular aneurysm repair is associated with improved short- and long-term outcomes.

J Card Surg 2022 Jun 11. Epub 2022 Jun 11.

Department of Surgical Treatment of Ischemic Heart Disease, Bakoulev's National Medical Research Centre for Cardiac Surgery, Moscow, Russia.

Background: Coronary artery bypass grafting (CABG) is recommended during acute postinfarction ventricular septal defect (PIVSD) repair, but clinical benefits of surgical revascularization in patients with subacute PIVSD have not been established. We aimed to evaluate the association of primary complete anatomic surgical myocardial revascularization (CASMR) during PIVSD and ventricular aneurysm (VA) repair on patients' short- and long-term outcomes.

Methods: This was a retrospective observational study. Read More

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ST-elevation myocardial infarction in the setting of non-obstructive coronaries.

J Cardiol Cases 2022 Jun 15;25(6):413-415. Epub 2022 Feb 15.

Medical College of Georgia, Augusta, GA, USA.

Myocardial infarction with non-obstructive coronary artery (MINOCA) accounts for 5-6% of all acute coronary syndrome presentations. Common causes of MINOCA include coronary vasospasm, coronary embolism/thrombosis, myocarditis, and spontaneous coronary artery dissection. Of them all, myocarditis is the most common cause of MINOCA, accounting for up-to 33% of all MINOCA cases. Read More

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Global burden of the COVID-19 associated patient-related delay in emergency healthcare: a panel of systematic review and meta-analyses.

Global Health 2022 Jun 8;18(1):58. Epub 2022 Jun 8.

Shiraz Azad University, Dental Branch, Shiraz, Iran.

Background: Apart from infecting a large number of people around the world and causing the death of many people, the COVID-19 pandemic seems to have changed the healthcare processes of other diseases by changing the allocation of health resources and changing people's access or intention to healthcare systems.

Objective: To compare the incidence of endpoints marking delayed healthcare seeking in medical emergencies, before and during the pandemic.

Methods: Based on a PICO model, medical emergency conditions that need timely intervention was selected to be evaluated as separate panels. Read More

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Takotsubo Syndrome and Sudden Cardiac Death.

Angiology 2022 Jun 6:33197221105757. Epub 2022 Jun 6.

First Department of Cardiology, Athens University School of Medicine, Athens, Greece.

Takotsubo syndrome (TTS), triggered by intense emotional or physical stress, occurring most commonly in post-menopausal women, presents as an ST-elevation myocardial infarction (MI). Cardiovascular complications occur in almost half the patients with TTS, and the inpatient mortality is comparable to MI (4-5%) owing to cardiogenic shock, myocardial rupture, or life-threatening arrhythmias. Thus, its prognosis is not as benign as previously thought, as it may cause mechanical complications (cardiac rupture) and potentially lethal arrhythmias and sudden cardiac death (SCD). Read More

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Acute STEMI Due to Severe Triple-Vessel Spasm After IV Adenosine Injection During Cryo-Balloon Isolation.

JACC Case Rep 2022 May 18;4(10):617-620. Epub 2022 May 18.

State University of New York, Upstate Medical University, Syracuse, New York, USA.

Adenosine IV is commonly used after pulmonary vein isolation to check for dormant electrical conduction. Herein, we present the case of a 60-year-old patient who exhibited marked hypotension, conduction abnormalities, and ST-segment elevation after routine adenosine injection. Coronary angiography revealed diffuse coronary spasm that was successfully treated with intracoronary nitroglycerin. Read More

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Coronary artery spasm due to acute myocarditis in an adolescent: a case report.

BMC Pediatr 2022 May 24;22(1):304. Epub 2022 May 24.

Department of Radiology, Pusan National University Yangsan Hospital, Yangsan-si, 50612, South Korea.

Background: Myocarditis refers to the inflammation of the myocardium caused by infection or autoimmune disease that may or may not present with clinical manifestations, such as gastrointestinal symptoms, dyspnea, chest pain, or sudden death. Although myocarditis and coronary artery vasospasm may mimic ST-segment elevation myocardial infarction (STEMI) with normal coronary arteries on angiography, acute myocarditis rarely causes coronary artery spasm. Here, we report a case of coronary artery spasm with reversible electrocardiographic changes mimicking STEMI in an adolescent with acute myocarditis. Read More

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Feasibility of nitroglycerin patch as a pretreatment for the distal radial approach: Study protocol for a randomized controlled trial (DRANG study).

Cardiovasc Revasc Med 2022 May 13. Epub 2022 May 13.

Department of Cardiovascular Medicine, National Cerebral & Cardiovascular Center, 6-1, Kishibe-shimmachi, Suita, Osaka 564-8565, Japan; Department of Advanced Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan.

Background: The distal radial approach (DRA) is a novel catheter cannulation technique to access the distal radial artery for coronary angiography (CAG). It is associated with less occurrence of puncture site occlusion than the conventional transradial approach. However, cannulation failure occasionally occurs due to difficulty in puncturing the smaller distal radial artery. Read More

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Left main coronary artery vasospasm: A case report of misdiagnosed severe coronary artery disease.

Ann Med Surg (Lond) 2022 Jun 29;78:103691. Epub 2022 Apr 29.

Department of Medicine, Division of Cardiology, Creighton University School of Medicine, Omaha, NE, USA.

Introduction And Importance: Left main coronary artery (LMCA) vasospasm is rare and can cause demand-supply mismatch that can mimic coronary artery disease (CAD). This could lead to misdiagnosis and inappropriate referral for surgical intervention.

Case Presentation: A 55-year-old woman with no cardiac risk factors presented with anginal chest pain. Read More

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Case Report: Acute Heart Failure Induced by the Combination of Takayasu's, Takotsubo and Coronary Vasospasm in an Elementary School Teacher-A Reaction to Return-to-Work Stress After COVID-19?

Front Psychiatry 2022 2;13:882870. Epub 2022 May 2.

Centro Cardiologico Monzino, IRCCs, Milan, Italy.

Introduction: Takayasu's arteritis (TA) is a systemic inflammatory disease that affects aorta and its major branches. There are several cardiac manifestations of TA and an association with Takotsubo syndrome (TTS) - but not coronary vasospasm - has been previously reported. The role of emotional stress in this context is unknown. Read More

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Androgenic steroids dysregulation and the risk of coronary artery disease.

Expert Rev Cardiovasc Ther 2022 May 19;20(5):343-349. Epub 2022 May 19.

Department of Internal Medicine, Ochsner Health System, New Orleans, LA, US.

Introduction: Endogenous testosterone deficiency or excess anabolic-androgenic steroids (AAS) have been linked to alter the physiology of different organs in the body, more specifically, the vasculature of coronary arteries. Despite the health-related concerns of using synthetic testosterone derivatives, such as AAS, there has been a tremendous increase in the use of AAS among athletes and bodybuilders.

Areas Covered: We have highlighted the three main mechanisms that AAS increase the risk of coronary artery disease (CAD): altering the homeostasis of lipid metabolism which results in dyslipidemia and subsequently atherosclerosis, disturbing the function of platelet which results in platelet aggregation and subsequent thrombosis, and increasing the risk of coronary vasospasm by affecting the physiological function of vascular bed. Read More

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Impact of drug-eluting stent-associated coronary artery spasm on 3-year clinical outcomes: A propensity score matching analysis.

Indian Heart J 2022 May-Jun;74(3):182-186. Epub 2022 May 13.

MBBS, Postgraduate Trainee Cardiology Department of Cardiology, Lady Reading Hospital, Peshawar Pakistan. Electronic address:

Background: It has been reported that significant endothelial dysfunction or clinically evident vasospasm can be associated with drug-eluting stents (DESs). However, the impact of DES associated coronary artery spasm (CAS) on long-term clinical outcomes has not been fully elucidated as compared with those of patients with vasospastic angina.

Methods: A total of 2797 consecutive patients without significant coronary artery lesion (<70%), who underwent the Acetylcholine (Ach) provocation test, were enrolled between Nov 2004 and Oct 2010. Read More

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Long-term health outcomes in young adults after Kawasaki disease.

Int J Cardiol Heart Vasc 2022 Jun 4;40:101039. Epub 2022 May 4.

Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

Background: We compared the long-term health of adults with prior Kawasaki disease (KD) to controls and determined whether outcomes varied by coronary artery (CA) status.

Methods: We conducted a prospective cohort study of 258 KD subjects (mean 19 ± 9 years since KD) and 148 age-similar controls who completed extensive health questionnaires. KD subjects were divided into 2 groups, Cohort 1: 109 subjects followed since KD diagnosis at our institution; Cohort 2: 149 KD subjects diagnosed elsewhere. Read More

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Epicardial and microvascular coronary artery spasm in biopsy-proven viral myocarditis.

Int J Cardiol 2022 Aug 6;360:1-4. Epub 2022 May 6.

Robert-Bosch-Krankenhaus, Department of Cardiology and Angiology, 70376 Stuttgart, Germany.

Background: Coronary spasm has been suggested to be the underlying mechanism of chest pain in patients with myocarditis and unobstructed coronary arteries. Here we sought to investigate a potential association between virus type and coronary spasm endotype in patients with biopsy-proven viral myocarditis.

Methods: A total of 618 consecutive patients with unobstructed coronary arteries who underwent endomyocardial biopsy between 2008 and 2018 were screened. Read More

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Bilateral pheochromcytomas presenting as shock: A rare case report.

J Family Med Prim Care 2022 Apr 18;11(4):1528-1531. Epub 2022 Mar 18.

Department of Cardiology, Shree Krishna Hospital and Pramukhswami Medical College, Karamsad, Gujarat, India.

Pheochromocytomas are rare chromaffin cell tumors of adrenal medulla (90%) that secrete catecholamines. Among children, the average age of presentation is 11-13 years, with a male preponderance of 2:1. Symptoms may be caused by catecholamine overproduction, local pressure, or metastasis. Read More

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Cardio-oncology in Austria: cardiotoxicity and surveillance of anti-cancer therapies : Position paper of the Heart Failure Working Group of the Austrian Society of Cardiology.

Wien Klin Wochenschr 2022 May 4. Epub 2022 May 4.

Department of Internal Medicine, Hospital of the Brothers of St. John of God (Krankenhaus Barmherzige Brüder) Salzburg, Salzburg, Austria.

Survival in cancer is continuously improving due to evolving oncological treatment. Therefore, cardiovascular short-term and long-term side effects gain crucial importance for overall outcome. Cardiotoxicity not only presents as heart failure, but also as treatment-resistant hypertension, acute coronary ischemia with plaque rupture or vasospasm, thromboembolism, arrhythmia, pulmonary hypertension, diastolic dysfunction, acute myocarditis and others. Read More

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Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest Pain.

Front Cardiovasc Med 2022 15;9:867155. Epub 2022 Apr 15.

Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Chest pain is a common symptom in patients with systemic lupus erythematosus, an autoimmune disease that is associated with increased cardiovascular morbidity and mortality. While chest pain mechanisms can be multifactorial and often attributed to non-coronary or non-cardiac cardiac etiologies, emerging evidence suggests that ischemia with no obstructive coronary arteries (INOCA) is a prevalent condition in patients with chest pain and no obstructive coronary artery disease. Coronary microvascular dysfunction is reported in approximately half of SLE patients with suspected INOCA. Read More

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Stent-Based Treatment of Refractory Coronary Vasospasm.

JACC Cardiovasc Interv 2022 May 27;15(10):e123-e124. Epub 2022 Apr 27.

Department of Cardiology, Inselspital, Bern University Hospital, Bern, Switzerland. Electronic address:

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Efficacy of Diltiazem to Improve Coronary Vasomotor Dysfunction in ANOCA: The EDIT-CMD Randomized Clinical Trial.

JACC Cardiovasc Imaging 2022 Apr 2. Epub 2022 Apr 2.

Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

Objectives: The randomized, placebo-controlled EDIT-CMD (Efficacy of Diltiazem to Improve Coronary Microvascular Dysfunction: A Randomized Clinical Trial) evaluated the effect of diltiazem on coronary vasomotor dysfunction (CVDys), as assessed by repeated coronary function testing (CFT), angina, and quality of life.

Background: Diltiazem is recommended and frequently prescribed in patients with angina and nonobstructive coronary artery disease (ANOCA), suspected of CVDys. However, studies substantiating its effect is this patient group are lacking. Read More

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Vasospasm-induced ST-segment elevation myocardial infarction in a premenopausal woman with endothelial dysfunction.

Oxf Med Case Reports 2022 Apr 19;2022(4):omac040. Epub 2022 Apr 19.

Division of Cardiology, Iruma Heart Hospital, Iruma city, Saitama, Japan.

ST-segment elevation myocardial infarction (STEMI) can be caused by coronary artery vasospasm (VSA) due to endothelial dysfunction. However, the clinical role of endothelial function tests in VSA-induced STEMI is not fully understood. We present the case of a 43-year-old woman with atypical chest pain and no coronary risk factors. Read More

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Case of coronary vasospasm caused by hypocalcaemia post parathyroidectomy mimicking ST-elevation myocardial infarction.

BMJ Case Rep 2022 Apr 21;15(4). Epub 2022 Apr 21.

ENT department, Galway University Hospital, Galway, Ireland.

A man in his 30s with primary hyperparathyroidism underwent an elective four-gland parathyroid exploration with intraoperative parathyroid hormone monitoring. On the fourth postoperative day (POD), the patient presented to the emergency department with severe symptomatic hypocalcaemia. ECG findings were in keeping with inferior-posterior ST-elevation myocardial infarction (STEMI); however, he was asymptomatic with no chest pain. Read More

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