5,225 results match your criteria Coronary Artery Vasospasm


An unusual thrombosis of an ostial left internal mammary artery graft causing acute coronary syndrome five years after coronary bypass surgery.

Turk Kardiyol Dern Ars 2019 Mar;47(2):137-139

Department of Cardiology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.

For long-term patency, a left internal mammary artery (LIMA) graft is considered the gold standard for left anterior descending artery (LAD) revascularization. Subsequent occlusion of a LIMA graft may be related to atherosclerosis, narrowing at anastomotic locations, fixed torsions within the graft, straight tubular stenosis, dissection, or vasospasm. Late thrombotic occlusion of a LIMA, however, is rare, and the cause is not known, though case reports can be found in the literature. Read More

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http://dx.doi.org/10.5543/tkda.2018.71643DOI Listing

Recurrent acute coronary syndrome in a patient with right coronary artery ectasia: a case report.

J Med Case Rep 2019 Mar 9;13(1):78. Epub 2019 Mar 9.

Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia.

Background: Coronary artery ectasia is characterized by an abnormal dilatation of the coronary arteries. Coronary artery ectasia is observed in 3-8% of patients undergoing coronary angiography and sometimes leads to acute coronary syndrome regardless of the presence or absence of coronary stenosis or atrial fibrillation.

Case Presentation: A 61-year-old Indonesian man presented with typical angina that began 1 week before admission and had worsened 3 hours prior to admission. Read More

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http://dx.doi.org/10.1186/s13256-019-1979-xDOI Listing
March 2019
1 Read

Transient Lingual Ischemia Complicating Coronary Angiography.

J Invasive Cardiol 2019 Mar;31(3):E51

University Hospital of Heraklion, Department of Cardiology, Voutes and Stavrakia, Heraklion, Crete, Greece, 71409.

Arterial embolism is a potential complication of coronary angiography and could theoretically affect the lingual circulation. However, the transient nature of clinical signs and symptoms suggests vasospasm as the most likely underlying mechanism of lingual ischemia in our case. Read More

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March 2019
1 Read

Cardiac Lymphatic Dysfunction Causes Drug-Eluting Stent-Induced Coronary Hyperconstricting Responses in Pigs In Vivo.

Arterioscler Thromb Vasc Biol 2019 Feb 28:ATVBAHA119312396. Epub 2019 Feb 28.

From the Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine (H.A., Y.M., S. Morosawa, K.O., H.U., M. Hirano, K.N., S. Miyata, H.S.).

Objective- We have previously demonstrated that coronary adventitial inflammation plays important roles in the pathogenesis of coronary vasomotion abnormalities, including drug-eluting stent (DES)-induced coronary hyperconstricting responses. Importantly, the adventitia also harbors lymphatic vessels, which may prevent inflammation by transporting extravasated fluid and inflammatory cells. We thus aimed to examine the roles of coronary adventitial lymphatic vessels in the pathogenesis of DES-induced coronary hyperconstricting responses in a porcine model in vivo. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312396DOI Listing
February 2019

Kounis syndrome induced by contrast media: A case report and review of literature.

Eur J Radiol Open 2019 12;6:91-96. Epub 2019 Feb 12.

Department of Diagnostic and Interventional Radiology, Gunma University Hospital, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.

Kounis syndrome (KS) is an acute coronary disorder associated with anaphylactic reactions. The purpose of this report is to identify the features of KS triggered by contrast media on the basis of our experience and from literature review. We have described a case and literature review of KS triggered by injection of contrast media. Read More

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http://dx.doi.org/10.1016/j.ejro.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374503PMC
February 2019
1 Read

Mechanisms of ST Elevation Myocardial Infarction in Patients Hospitalized for Noncardiac Conditions.

Am J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Division of Cardiology University of North Carolina, Chapel Hill, North Carolina; McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

ST elevation myocardial infarction (STEMI) occurring in patients hospitalized for a noncardiac condition is associated with a high mortality rate and thus we sought to determine the mechanisms underlying STEMI in this patient population. This is a single center retrospective study of 70 patients who had STEMI while hospitalized on a noncardiac service and underwent coronary angiography. Thrombotic in-hospital STEMI was defined by angiographic or intravascular imaging evidence of intracoronary thrombus, plaque rupture, or stent thrombosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193016
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http://dx.doi.org/10.1016/j.amjcard.2019.01.039DOI Listing
February 2019
3 Reads

Coronary epicardic vasospasm in patient treated with desatinib for lymphoblastic leukaemia: the other side of the medal.

Eur Heart J 2019 Feb 12. Epub 2019 Feb 12.

Interventional Cardiology Department, Mazzoni Hospital, Via degli Iris 1, Ascoli Piceno, Italy.

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http://dx.doi.org/10.1093/eurheartj/ehz054DOI Listing
February 2019
1 Read

Coronary Artery Spasm, Coronary Reactivity and Their Psychological Context.

Psychosom Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA.

Symptomatic individuals suspected of having myocardial ischemia often have no obstructive atherosclerotic narrowing of epicardial coronary arteries. Abnormal coronary vascular reactivity, and in particular, coronary artery vasospasm (CAS), may be an explanation in a subset of these patients. Psychological factors play an important role in ischemic heart disease, but their role in CAS is not clear; autonomic dysfunction and increased inflammation are two prevailing pathophysiological mechanisms implicated in abnormal coronary reactivity resulting from mental health conditions. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000682DOI Listing
February 2019
10 Reads

Coronary artery spasm - Clinical features, pathogenesis and treatment.

Proc Jpn Acad Ser B Phys Biol Sci 2019 ;95(2):53-66

Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute.

Coronary artery spasm (CAS) plays an important role in the pathogenesis of ischemic heart disease, including angina pectoris, myocardial infarction, and sudden death, occurring most often from midnight to early morning. CAS is prevalent among East Asians and is associated with an aldehyde dehydrogenase 2 (ALDH2)-deficient genotype (ALDH2*2) and alcohol flushing, which is prevalent among East Asians but is virtually non-existent in other populations. ALDH2 eliminates not only acetaldehyde but also other toxic aldehydes from lipid peroxidation and tobacco smoking, thereby protecting tissues and cells from oxidative damage. Read More

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http://dx.doi.org/10.2183/pjab.95.005DOI Listing
February 2019
2 Reads

Coronary artery spasm induced by carotid sinus stimulation during arthroscopic shoulder surgery: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14352

Department of Anesthesiology and Pain Medicine, Soonchunhyang University, Seoul Hospital, Seoul, Republic of Korea.

Rationale: Variant angina is characterized by coronary artery spasm irrespective of the presence of fixed stenotic coronary lesions. Perioperative coronary artery spasm may be induced by the supersensitivity of vascular smooth muscle cells caused by various stimuli, including stimulation of the parasympathetic nervous system.

Patient Concerns: A 57-year-old male patient was undergoing arthroscopic rotator cuff repair under combined interscalene brachial plexus block and general anesthesia in the lateral decubitus position. Read More

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http://Insights.ovid.com/crossref?an=00005792-201902010-0007
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http://dx.doi.org/10.1097/MD.0000000000014352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380765PMC
February 2019
10 Reads

Extreme ST-segment elevations in seemingly no significant angiographic coronary artery abnormalities: a case report.

BMC Cardiovasc Disord 2019 Jan 29;19(1):28. Epub 2019 Jan 29.

Maastricht University Medical Center (MUMC+), P. Debyelaan 25, 6229HX, Maastricht, The Netherlands.

Background: Obstructive coronary artery disease is found in approximately 97% of patients presenting with ST-elevation myocardial infarction and 92% of patients with non ST-elevation myocardial infarction (Bainey KR, Welsh RC, Alemayehu W, Westerhout CM, Traboulsi D, Anderson T, et al. Int J Cardiol 264: 12-17, 2018). Recent studies showed that myocardial infarction without obstructive coronary atherosclerosis (MINOCA) is also associated with a long-term risk of adverse events (Bainey KR, Welsh RC, Alemayehu W, Westerhout CM, Traboulsi D, Anderson T, et al. Read More

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http://dx.doi.org/10.1186/s12872-019-1010-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350352PMC
January 2019
1 Read

Acute coronary stent thrombosis: A case of type 3 Kounis syndrome.

J Cardiol Cases 2019 Jan 23;19(1):33-35. Epub 2018 Oct 23.

Cardiology Unit, Sant'Anna Hospital, Catanzaro, Italy.

Kounis syndrome refers to an acute coronary syndrome, consequent to an allergic reaction. It results from mast cell degranulation with subsequent release of numerous inflammatory mediators, leading to coronary vasospasm, atheromatous plaque rupture, or stent thrombosis. Here, we describe the case of a 47-year-old Caucasian man with acute stent thrombosis, as a consequence of allergic reaction to contrast media. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18785409183009
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http://dx.doi.org/10.1016/j.jccase.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342681PMC
January 2019
5 Reads

Myocardial infarction with non-obstructive coronary arteries: a focus on vasospastic angina.

Neth Heart J 2019 Jan 28. Epub 2019 Jan 28.

Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Vasospastic angina (VSA) is considered a broad diagnostic category including documented spontaneous episodes of angina pectoris produced by coronary epicardial vasospasm as well as those induced during provocative coronary vasospasm testing and coronary microvascular dysfunction due to microvascular spasm. The hallmark feature of VSA is rest angina, which promptly responds to short-acting nitrates; however, VSA can present with a great variety of symptoms, ranging from stable angina to acute coronary syndrome and even ventricular arrhythmia. VSA is more prevalent in females, who can present with symptoms different from those among male patients. Read More

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http://link.springer.com/10.1007/s12471-019-1232-7
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http://dx.doi.org/10.1007/s12471-019-1232-7DOI Listing
January 2019
7 Reads

Difficult management of a patient presenting with recurrent syncope caused by diffuse vasospasm.

North Clin Istanb 2018 Sep;5(3):264-267

Department of Cardiology, Health Sciences University, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.

Spontaneous and simultaneous multivessel coronary artery spasm may present with multisite myocardial ischemia, atrioventricular block, acute lung edema, cardiogenic shock, or ventricular fibrillation. In a case of syncope caused by vasospasm, the underlying mechanism may be complex, such as atrioventricular block and/or ventricular arrhythmia. Dual implantable cardioverter defibrillator (ICD) placement should be considered along with optimal medical treatment. Read More

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http://dx.doi.org/10.14744/nci.2017.82160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323576PMC
September 2018
1 Read

Propofol-Induced Vasodilation in Human Internal Mammary Artery: Role of Potassium Channels.

J Cardiothorac Vasc Anesth 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacology, Adiyaman University, Adiyaman, Turkey.

Objectives: The aim of this study was to investigate the vascular effects and mechanisms of propofol in the human internal mammary artery (IMA).

Design: In vitro experimental study.

Setting: The study was conducted in the research laboratory of a pharmacology department. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10530770183112
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http://dx.doi.org/10.1053/j.jvca.2018.12.015DOI Listing
December 2018
8 Reads

Myocardial Infarction With Nonobstructive Coronary Arteries Assessed by 11C-Acetate Cardiac PET.

Clin Nucl Med 2019 Mar;44(3):e166-e167

Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea.

C-acetate PET can quantify myocardial blood flow and oxidative metabolism (kmono) with a single imaging study. We present a 63-year-old man with myocardial infarction with nonobstructive coronary arteries due to vasospasm, who underwent C-acetate PET after antispastic medication. By quantifying myocardial blood flow and kmono, C-acetate PET could detect the initial ischemic insult by vasospasm and sufficient amount of remaining viable myocardium, while excluding significant inducible ischemia. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002431DOI Listing
March 2019
1 Read

Relaxation matters: comparison of in-vitro vasodilatory role of botulinum toxin-A and papaverine in human radial artery grafts.

J Cardiothorac Surg 2019 Jan 21;14(1):15. Epub 2019 Jan 21.

Department of Pharmacology, Meram Medicine Faculty, Necmettin Erbakan University, Konya, Turkey.

Background: Radial artery (RA) is widely used in coronary artery bypass (CABG) surgery and the prevention of spasm is crucial for graft patency. Botulinum toxin A (BTX-A) and B are commonly used for aesthetic reasons and neuromuscular disorders. They are proven to raise blood flow and increase survival of ischemic skin flaps. Read More

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http://dx.doi.org/10.1186/s13019-019-0837-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341691PMC
January 2019
1 Read

Impact of multi-vessel vasospastic angina on cardiovascular outcome.

Atherosclerosis 2019 Feb 23;281:107-113. Epub 2018 Dec 23.

Department of Cardiovascular Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea. Electronic address:

Background And Aims: Since clinical characteristics and prognosis of patients with multi-vessel vasospastic angina (VSA) are not clear, we investigated the nature and prognosis of multi-vessel VSA in Koreans.

Methods: Among 2960 patients enrolled in the VA-KOREA (Vasospastic Angina in Korea) registry, 104 definite multi-vessel VSA patients, 163 single vessel VSA patients and 737 non-VSA patients were identified using the intracoronary ergonovine provocation test.

Results: Multi-vessel VSA and single vessel VSA groups showed similar baseline characteristics and medical treatment on discharge, but different from the non-VSA group. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219150183154
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http://dx.doi.org/10.1016/j.atherosclerosis.2018.12.018DOI Listing
February 2019
14 Reads

Vasodilatory Efficacy and Impact of Papaverine on Endothelium in Radial Artery Predilatation for CABG Surgery: in Search for Optimal Concentration.

Braz J Cardiovasc Surg 2018 Nov-Dec;33(6):553-558

Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Jagiellonian University Medical College, Krakow, Poland.

Objective: The aim of this study was to compare the efficacy of two different papaverine concentrations (0.5 mg/ml and 2 mg/ml) for vasospasm prevention and their impact on endothelium integrity.

Methods: We have studied distal segments of radial arteries obtained by no-touch technique from coronary artery bypass graft (CABG) patients (n=10). Read More

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http://dx.doi.org/10.21470/1678-9741-2018-0139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326436PMC
March 2019
2 Reads

Kounis syndrome induced by oral intake of aspirin: case report and literature review.

Pan Afr Med J 2018 30;30:301. Epub 2018 Aug 30.

Department of Cardiology B, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.

The Kounis-Zavras syndrome is defined as the coincidental occurrence of acute coronary events and hypersensitivity reactions following an allergic reaction including a mast-cell degranulation of vasospastic mediators. This report describes a case of Kounis-Zavras syndrome in the setting of aspirin-induced asthma also known as Samter-Beer triad combining nasal polyps, asthma, and aspirin allergy leading to vasospasm and myocardial infarction. All physicians should be aware of The Kounis syndrome and always keep that unique clinical entity in mind to recognize it promptly and direct the therapy at suppressing the allergic reaction. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.301.14948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320451PMC
January 2019
1 Read

Post-partum Spontaneous Coronary Artery Dissection: A Case Report.

Am J Med Case Rep 2018 7;6(10):218-221. Epub 2018 Dec 7.

Division of Rheumatology, Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203 USA.

Spontaneous coronary artery dissection (SCAD) is a rare illness often misdiagnosed, that accounts for up to 4% of cases of acute coronary syndrome in young women. Interestingly, SCAD is the most common cause of myocardial infarction related to pregnancy. Here, we present a case of a 35-year old postpartum patient who presented in cardiac arrest due to ventricular fibrillation and was found to have a ST-segment elevation myocardial infarction. Read More

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http://pubs.sciepub.com/ajmcr/6/10/6/index.html
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http://dx.doi.org/10.12691/ajmcr-6-10-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322694PMC
December 2018
6 Reads

Unexpected, But Reasonable Association Between Anderson-Fabry Disease and Coronary Vasospasm.

Circ J 2019 Jan 29;83(2):283-284. Epub 2018 Dec 29.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University.

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http://dx.doi.org/10.1253/circj.CJ-18-1355DOI Listing
January 2019
1 Read

Marijuana-associated ST-elevation myocardial infarction: is this a benign drug.

BMJ Case Rep 2018 Dec 13;11(1). Epub 2018 Dec 13.

Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, Florida, USA.

Marijuana is the most commonly used psychoactive drug in the USA. A 35-year-old man with a medical history of marijuana abuse is admitted to the hospital due to crushing substernal chest pain. ECG shows evolving ST-segment elevation with a rise in cardiac enzymes, consistent with ST-elevation myocardial infarction. Read More

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http://dx.doi.org/10.1136/bcr-2018-226894DOI Listing
December 2018
1 Read

Lambda-like ST-segment elevation in acute myocardial infarction triggered by coronary spasm may be a new risk predictor for lethal ventricular arrhythmia: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13561

Department of Cardiology.

Rationale: The lambda-like ST-elevation electrocardiography (ECG) pattern is extremely rare in patients with type 2 myocardial infarction (T2MI) triggered by coronary spasm. When this ECG pattern appears, sudden cardiac death (SCD) caused by lethal ventricular arrhythmia may occur because clinicians do not pay sufficient attention to this phenomenon.

Patient Concerns: We describe a 41-year-old man who presented with steep down-sloping ST-segment elevation, paroxysmal ventricular tachycardia, severe sinus bradycardia, and intermittent complete atrioventricular block on ECG during the sudden recurrence of clinical symptoms. Read More

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http://dx.doi.org/10.1097/MD.0000000000013561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310568PMC
December 2018

Intraprocedure Type II Kounis Syndrome Secondary to Radioiodine Contrast During Coronary Angiography.

Can J Cardiol 2018 Dec 24;34(12):1688.e1-1688.e3. Epub 2018 Aug 24.

Department of Cardiology, Westmead Hospital, New South Wales, Australia.

An 83-year-old man with a previous right coronary artery (RCA) stent presented to the emergency department with syncope, dynamic lateral ST depression, and a serum troponin of 6148 ng/L (< 17). Coronary angiography revealed a patent proximal RCA stent and significant left-sided disease. The procedure was complicated by inferior ST elevation, urticaria, hypotension, and acute proximal RCA occlusion. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.08.029DOI Listing
December 2018
4 Reads

Coronary Vasospasm Following Heart Transplantation: Rapid Progression to Aggressive Cardiac Allograft Vasculopathy.

Can J Cardiol 2018 Dec 20;34(12):1687.e9-1687.e11. Epub 2018 Aug 20.

Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

Coronary artery vasospasm (CVS) has been described in orthotopic heart transplant patients but is rare in the post-transplanted, denervated heart. Severe CVS has been associated with accelerated cardiac allograft vasculopathy (CAV) and allograft rejection. Allograft vasculopathy is the leading cause of decreased long-term survival in orthotopic heart transplant. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.08.022DOI Listing
December 2018
2 Reads

A silent myocardial infarction with normal coronary arteries associated with Graves' disease.

Heart Lung 2018 Nov 28. Epub 2018 Nov 28.

Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology, Jiefang Road 1095, Wuhan 430030, Hubei, PR China. Electronic address:

Acute myocardial infarction (AMI) is a scarce but fatal complication in Graves' disease (GD). Silent myocardial infarction (MI) associated with GD has never been reported. A 37-year-old male patient was admitted due to poorly controlled hyperthyroidism and persistent fever. Read More

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http://dx.doi.org/10.1016/j.hrtlng.2018.11.003DOI Listing
November 2018
2 Reads

Coronary spasm: It's common, but it's still unsolved.

World J Cardiol 2018 Nov;10(11):201-209

Department of Cardiovascular Medicine, JR Hiroshima Hospital, Hiroshima 732-0057, Japan.

Coronary spasm is caused by a transient coronary narrowing due to the constriction of epicardial coronary artery, which leads to myocardial ischemia. More than 50 years have passed since the first recognition of coronary spasm, and many findings on coronary spasm have been reported. Coronary spasm has been considered as having pivotal roles in the cause of not only rest angina but also exertional angina, acute coronary syndrome, and heart failure. Read More

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http://dx.doi.org/10.4330/wjc.v10.i11.201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259026PMC
November 2018

Multivessel coronary artery spasm in pericarditis.

Singapore Med J 2018 Nov;59(11):611-613

Department of Cardiology, National University Heart Centre, Singapore.

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http://dx.doi.org/10.11622/smedj.2018138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250754PMC
November 2018
2 Reads

The multi-vessel and diffuse coronary spasm is a risk factor for persistent angina in patients received anti-angina medication.

Medicine (Baltimore) 2018 Nov;97(47):e13288

Cardiovascular Division, Department of Internal Medicine, Dankook University Hospital, Cheonan, Korea.

Coronary artery spasm (CAS) is known to be a risk factor for cardiovascular events. However, there is limited data whether the multi-vessel and diffuse spasm (MVDS) is related to more adverse clinical outcomes compared to the Non-MVDS. The aim of this study is to evaluate the impact of the MVDS on clinical outcomes during a 3-year clinical follow-up period. Read More

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http://dx.doi.org/10.1097/MD.0000000000013288DOI Listing
November 2018
5 Reads

Advanced imaging techniques (CT and MR): Gender-based diagnostic work-up in ischemic heart disease?

Int J Cardiol 2018 Nov 7. Epub 2018 Nov 7.

Centro Cardiologico Monzino, IRCCS, Milan, Italy. Electronic address:

It is ascertained that the epidemiology and social impact of ischemic heart disease is substantially different between the two genders. Moreover, there is substantial evidence that gender is able to modulate the clinical manifestation of most cardiac diseases, and specifically of coronary artery disease. Particularly, women present less angiographically significant coronary artery disease, smaller vessel lumen, and less plaque rupture occurrence as compared to men. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.11.010DOI Listing
November 2018
10 Reads

Fatal Vasospasm of the Coronary Arteries in a Patient Undergoing Distal Bypass Surgery and Endovascular Therapy for Threatened Lower Limbs Due to Acute Exacerbation of Peripheral Arterial Disease.

Ann Vasc Dis 2018 Sep;11(3):369-372

Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

A 79-year-old man with a heavy smoking history presented with threatened lower limbs due to acute exacerbation of peripheral artery disease (PAD). He underwent emergent distal bypass surgery for the right leg and external iliac stenting for the left leg. Fatal coronary artery spasm (CAS) with ST segment changes on electrocardiography was observed 28 h after the procedures, resulting in cardiac arrest. Read More

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https://www.jstage.jst.go.jp/article/avd/11/3/11_cr.18-00050
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http://dx.doi.org/10.3400/avd.cr.18-00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200607PMC
September 2018
13 Reads

Bolus 5-fluorouracil (5-FU) In Combination With Oxaliplatin Is Safe and Well Tolerated in Patients Who Experienced Coronary Vasospasm With Infusional 5-FU or Capecitabine.

Clin Colorectal Cancer 2018 Oct 10. Epub 2018 Oct 10.

Department of Medical Oncology, Mayo Clinic, Rochester, MN.

Introduction: Coronary vasospasm associated with fluoropyrimidine (FP)-based chemotherapy is a potentially serious complication and reported to occur more often with infusional 5-fluorouracil (5-FU) or capecitabine than with bolus 5-FU. Given the additional benefit of oxaliplatin over FP alone in the management of colorectal cancer, retaining oxaliplatin in the treatment regimen is desirable, but the safety of combining bolus 5-FU with oxaliplatin in patients with FP-induced vasospasm is not well established. We performed a retrospective review to explore the safety of substituting FLOX (bolus 5-FU, oxaliplatin, leucovorin) for FOLFOX (infusional 5-FU, oxaliplatin, leucovorin) and CAPOX (capecitabine, oxaliplatin) in patients who had FP-induced coronary vasospasm. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.09.006DOI Listing
October 2018
2 Reads

New onset acute pulmonary edema after methylergonovine given during cesarean delivery of a patient with undiagnosed Raynaud's disease.

Int J Obstet Anesth 2018 Nov 29;36:111-114. Epub 2018 May 29.

The Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21287, USA.

Raynaud's disease is a medical condition in which arterial spasm causes episodes of reduced blood flow, in the setting of certain triggers such as cold weather. Patients with this condition are at risk of adverse reactions if they receive medications with vasoactive properties. Methylergonovine maleate is one drug used during cesarean delivery to treat postpartum hemorrhage due to uterine atony. Read More

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http://dx.doi.org/10.1016/j.ijoa.2018.05.006DOI Listing
November 2018
6 Reads

Coronary artery vasospasm in a patient withChurg-Strauss syndrome.

BMJ Case Rep 2018 Oct 25;2018. Epub 2018 Oct 25.

Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia.

Patients with Churg-Strauss syndrome often suffer from unusual cardiac manifestations and sudden cardiac death. This differs from patients with other autoimmune disorders, who typically present with premature ischaemic heart disease. We report the case of a 56-year-old man with recurrent coronary vasospasm, including an inferoposterior ST-elevation myocardial infarction, complicated by bradycardic arrest. Read More

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http://dx.doi.org/10.1136/bcr-2018-225321DOI Listing
October 2018
3 Reads

Responses of Endothelial Cells Towards Ischemic Conditioning Following Acute Myocardial Infarction.

Cond Med 2018 Aug;1(5):247-258

Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.

One of the primary therapeutic goals of modern cardiology is to design strategies aimed at minimizing myocardial infarct size and optimizing cardiac function following acute myocardial infarction (AMI). Patients with AMI who underwent reperfusion therapy display dysfunction of the coronary endothelium. Consequently, ischemic endothelial cells become more permeable and weaken their natural anti-thrombotic and anti-inflammatory potential. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191189PMC
August 2018
2 Reads

Impact of Insulin Resistance on Acetylcholine-Induced Coronary Artery Spasm in Non-Diabetic Patients.

Yonsei Med J 2018 Nov;59(9):1057-1063

Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.

Purpose: Coronary artery spasm (CAS) and diabetes mellitus (DM) are implicated in endothelial dysfunction, and insulin resistance (IR) is a major etiological cause of type 2 DM. However, the association between CAS and IR in non-diabetic individuals has not been elucidated. The aim of the present study was to evaluate the impact of IR on CAS in patients without DM. Read More

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http://dx.doi.org/10.3349/ymj.2018.59.9.1057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192881PMC
November 2018
3 Reads

Fasudil, a Rho-Kinase Inhibitor, Exerts Cardioprotective Function in Animal Models of Myocardial Ischemia/Reperfusion Injury: A Meta-Analysis and Review of Preclinical Evidence and Possible Mechanisms.

Front Pharmacol 2018 1;9:1083. Epub 2018 Oct 1.

Department of Internal Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Fasudil, a Rho-kinase inhibitor, has shown outstanding therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH) in humans. Studies show various biological effects of fasudil in the cardiovascular system. We conducted a preclinical systematic review to determine the efficacy and possible mechanisms of fasudil on animal models of myocardial ischemia/reperfusion (I/R) injury. Read More

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http://dx.doi.org/10.3389/fphar.2018.01083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174418PMC
October 2018
3 Reads

Phase I/II study of everolimus combined with mFOLFOX-6 and bevacizumab for first-line treatment of metastatic colorectal cancer.

Invest New Drugs 2018 Oct 10. Epub 2018 Oct 10.

Division Clinical Sciences, Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.

Background This phase I/II trial evaluated toxicity and antitumor activity of everolimus plus mFOLFOX6 + bevacizumab for first-line treatment of metastatic colorectal cancer (mCRC). Methods A phase I, modified 3 + 3 Fibonacci schema determined the maximum tolerated dose (MTD) of everolimus, followed by phase II dose expansion. The phase II primary objective was progression-free survival at 6 months (PFS-6 m). Read More

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http://dx.doi.org/10.1007/s10637-018-0645-2DOI Listing
October 2018
3 Reads
2.920 Impact Factor

Evaluation and medical therapy for coronary endothelial dysfunction induced by sirolimus-eluting stent in patient with an atherosclerotic lesion of the left main coronary artery: Case report.

J Cardiol Cases 2017 Dec 22;16(6):189-193. Epub 2017 Sep 22.

Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.

Sirolimus-eluting stents (SES), especially those deployed at distal sites, cause more coronary vasospasm and endothelial dysfunction in the chronic phase compared to bare-metal stents (BMS). In comparison, endothelial dysfunction is less frequently induced by the Biolimus-A9 eluting stent (BES). A 75-year-old man with effort-induced angina pectoris previously underwent a total of three SES implantations in the left anterior descending coronary artery (LAD) and right coronary artery (RCA) in 2010 and 2011. Read More

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http://dx.doi.org/10.1016/j.jccase.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149632PMC
December 2017
4 Reads

Identification of Coronary Vasospasm as a Cause of Recurrent Acute Coronary Syndrome.

J Invasive Cardiol 2018 Oct;30(10):E100

Heart Center Leipzig - University Hospital, Struempellstrasse 39, 04289 Leipzig, Germany.

A case highlighting the importance of nitrate administration, as routinely performed during coronary arteriography. Read More

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October 2018
7 Reads

[Coronary spasm a diagnostic and therapeutic challenge].

Presse Med 2018 Sep 21;47(9):798-803. Epub 2018 Sep 21.

Institut Jacques-Cartier, groupe Ramsay, 6, avenue du Noyer-Lambert, 91300 Massy, France.

Vasospastic angina is a clinical and physio-pathological entity, which has been documented for many years, but its diagnosis is under-estimated despite the fact that though inadequately considered and investigated. This condition is potentially serious and can sometimes trigger severe arrhythmia resulting in ventricular fibrillation and sudden death. This pathology has a higher incidence in Asia, where it is, therefore, better documented with provocative testing being carried out more frequently, while in France, these tests are not sufficiently performed probably due to the fact that they often produce negative findings. Read More

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http://dx.doi.org/10.1016/j.lpm.2018.08.004DOI Listing
September 2018
2 Reads
1.173 Impact Factor

Ergonovine Stress Echocardiography for the Diagnosis of Vasospastic Angina and Its Prognostic Implications in 3,094 Consecutive Patients.

Korean Circ J 2018 Oct;48(10):906-916

Division of Cardiology, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.

Background And Objectives: Ergonovine stress echocardiography (ErgECHO) has been proposed as a noninvasive tool for the diagnosis of coronary vasospasm. However, concern over the safety of ErgECHO remains. This study was undertaken to investigate the safety and prognostic value of ErgECHO in a large population. Read More

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http://dx.doi.org/10.4070/kcj.2017.0395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158448PMC
October 2018
3 Reads

Catecholamine-Induced Cardiomyopathy in Pheochromocytoma: How to Manage a Rare Complication in a Rare Disease?

Horm Metab Res 2018 Sep 18. Epub 2018 Sep 18.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

Pheochromocytomas and paragangliomas (PHEOs) are rare neuroendocrine tumors. Clinical manifestations include different cardiovascular signs and symptoms, which are related to excessive secretion of catecholamines. Catecholamine-induced cardiomyopathy in PHEO (CICMPP) is a rare but dreaded complication of PHEO. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0669-9556
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http://dx.doi.org/10.1055/a-0669-9556DOI Listing
September 2018
7 Reads

Vasospastic angina: A literature review of current evidence.

Arch Cardiovasc Dis 2019 Jan 7;112(1):44-55. Epub 2018 Sep 7.

Cardiology department, hôpital Cochin, AP-HP, 75014 Paris, France; Faculté de médecine, université Paris Descartes, 75006 Paris, France.

Vasospastic angina (VSA) is a variant form of angina pectoris, in which angina occurs at rest, with transient electrocardiogram modifications and preserved exercise capacity. VSA can be involved in many clinical scenarios, such as stable angina, sudden cardiac death, acute coronary syndrome, arrhythmia or syncope. Coronary vasospasm is a heterogeneous phenomenon that can occur in patients with or without coronary atherosclerosis, can be focal or diffuse, and can affect epicardial or microvasculature coronary arteries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18752136183013
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http://dx.doi.org/10.1016/j.acvd.2018.08.002DOI Listing
January 2019
26 Reads

ST segment elevation myocardial infarction with normal coronary arteries.

Heart Asia 2018 17;10(2):e011084. Epub 2018 Aug 17.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

Case Presentation: A middle-aged patient presented to the emergency department with intermittent chest pain of 4-hour duration. The patient had been recently diagnosed with metastatic adenocarcinoma of the colon and was receiving 5-fluorouracil (5-FU)-based chemotherapy at the time of presentation. The ECG at presentation showed 1 mm ST segment elevation in leads II, III and aVF, with reciprocal changes in leads aVL, V1 and V2 (figure 1A). Read More

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http://heartasia.bmj.com/lookup/doi/10.1136/heartasia-2018-0
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http://dx.doi.org/10.1136/heartasia-2018-011084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109945PMC
August 2018
25 Reads

Fistulae ligation and left main artery ligation for a bilateral giant coronary arterial fistulae-related aneurysm.

Eur J Cardiothorac Surg 2018 Aug 27. Epub 2018 Aug 27.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China.

Bilateral congenital coronary artery fistulae complicated with a giant coronary artery aneurysm is a very rare condition. A coronary artery aneurysm is a coronary artery dilatation that exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times. Read More

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https://academic.oup.com/ejcts/advance-article/doi/10.1093/e
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http://dx.doi.org/10.1093/ejcts/ezy287DOI Listing
August 2018
11 Reads
3.304 Impact Factor

Systemic microvascular dysfunction in microvascular and vasospastic angina.

Eur Heart J 2018 Dec;39(46):4086-4097

West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, GJNH, Agamemnon St, Glasgow, UK.

Aims: Coronary microvascular dysfunction and/or vasospasm are potential causes of ischaemia in patients with no obstructive coronary artery disease (INOCA). We tested the hypothesis that these patients also have functional abnormalities in peripheral small arteries.

Methods And Results: Patients were prospectively enrolled and categorised as having microvascular angina (MVA), vasospastic angina (VSA) or normal control based on invasive coronary artery function tests incorporating probes of endothelial and endothelial-independent function (acetylcholine and adenosine). Read More

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http://dx.doi.org/10.1093/eurheartj/ehy529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284165PMC
December 2018
6 Reads

Coronary Artery Vasospasm.

Authors:
Jae Kwan Song

Korean Circ J 2018 Sep;48(9):767-777

Department of Cardiology, Asan Medical Center Heart Institute, University of Ulsan College of Medicine, Seoul, Korea.

Coronary artery vasospasm (CVS) is an important mechanism of myocardial ischemia and produces any of the manifestations of coronary artery disease from silent myocardial ischemia, to effort-induced angina and variant angina, to acute coronary syndrome including myocardial infarction or sudden cardiac death. The pathogenesis, characteristic clinical features, diagnosis, and treatment of CVS are summarized. Emphasis is placed on correct diagnosis of CVS using pharmacological spasm provocation test, either during coronary angiography or with echocardiographic monitoring of ventricular wall motion. Read More

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http://dx.doi.org/10.4070/kcj.2018.0251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110699PMC
September 2018
2 Reads