5,450 results match your criteria Coronary Artery Vasospasm


Diagnostic work-up and therapeutic implications in MINOCA: need for a personalized approach.

Future Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiovascular & Thoracic Sciences, Institute of Cardiology, Catholic University of The Sacred Heart, Rome, Italy.

Myocardial infarction with non-obstructive coronary artery (MINOCA) disease represents a heterogeneous clinical conundrum accounting for about 6% of all acute myocardial infarction (MI) cases. Initially believed to be a benign condition, is now becoming clear that MINOCA is associated with a non-negligible risk of mortality, rehospitalization, disability and angina burden at follow-up, with high socioeconomic costs. To date, there are no prospective clinical trials in this population and cannot be assumed that benefits observed in patients suffering from MI with obstructive coronary artery disease may successfully translate to this syndrome. Read More

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http://dx.doi.org/10.2217/fca-2020-0052DOI Listing

An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group.

Eur Heart J 2020 Jul 6. Epub 2020 Jul 6.

Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London and Barts Heart Centre, London, UK.

This consensus document, a summary of the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), appraises the importance of ischaemia with non-obstructive coronary arteries (INOCA). Angina pectoris affects approximately 112 million people globally. Up to 70% of patients undergoing invasive angiography do not have obstructive coronary artery disease, more common in women than in men, and a large proportion have INOCA as a cause of their symptoms. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa503DOI Listing

An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group.

EuroIntervention 2020 Jul 6. Epub 2020 Jul 6.

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University and Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.

This consensus document, a summary of the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), appraises the importance of ischaemia with non-obstructive coronary arteries (INOCA). Angina pectoris affects approximately 112 million people globally. Up to 70% of patients undergoing invasive angiography do not have obstructive coronary artery disease, more common in women than in men, and a large proportion have INOCA as a cause of their symptoms. Read More

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http://dx.doi.org/10.4244/EIJY20M07_01DOI Listing

Fatal Multi-Vessel Coronary Vasospasm: A Case Report.

Cureus 2020 May 25;12(5):e8271. Epub 2020 May 25.

Cardiology, Mohammed I University/Mohammed VI University Hospital, Oujda, MAR.

We report a case of a 59-year-old female who experienced a history of an acute ST myocardial infarction. Percutaneous intervention and isosorbide dinitrate perfusion were successful in reversing the severe vasospasm on the left anterior descending, the first diagonal, and posterior interventricular arteries. The patient received calcium channel blockers and nitrates with a good in-hospital clinical evolution. Read More

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http://dx.doi.org/10.7759/cureus.8271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314376PMC

Acute myocardial injury after administration of intravenous epinephrine for allergic reaction.

SAGE Open Med Case Rep 2020 17;8:2050313X20933104. Epub 2020 Jun 17.

Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Myocardial injury or infarction in the setting of anaphylaxis can be due to anaphylaxis itself, known as Kounis syndrome, or as a result of treatment with epinephrine. Myocardial ischemia caused by therapeutic doses of epinephrine in the setting of anaphylaxis is a rare event attributed to coronary artery vasospasm. A 41-year-old female with past medical history of recurrent costochondritis, chronic thrombocytopenia, and nonspecific palindromic rheumatism presented to the emergency department with perioral numbness, flushing and throat tightness after a meal containing fish and almonds. Read More

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http://dx.doi.org/10.1177/2050313X20933104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301683PMC

Recurrent Coronary Vasospasm After Cardiac Surgery.

Ann Thorac Surg 2020 Jun 5. Epub 2020 Jun 5.

Division of Cardiac Surgery, Montreal Heart Institute, University of Montreal, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada. Electronic address:

Post-operative coronary vasospasm is a rare but potentially life-threatening complication after cardiac surgery. We present the case of a young patient with osteogenesis imperfecta who developed coronary vasospasm after each of his two aortic valve procedures. We believe this case provides new information about the presentation, potential for recurrence and clinical progression of perioperative coronary vasospasm. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.082DOI Listing

Long-Term Prognosis of Patients with Myocardial Infarction Type 1 and Type 2 with and without Involvement of Coronary Vasospasm.

J Clin Med 2020 Jun 2;9(6). Epub 2020 Jun 2.

Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.

While prognoses in relation to myocardial infarction (MI) type have been elucidated in past reports, the results were not consistent, perhaps due to occurrence of Type 2 MI with CVS and its mortality. The Japanese registry of acute Myocardial Infarction diagnosed by Universal Definition (J-MINUET) is a prospective multicenter registry in Japan. In contrast to thromboembolic event-related Type 1 myocardial infarction (MI), clinical features of Type 2 MI, including coronary vasospasm (CVS), are varied due to the heterogeneous nature of its development. Read More

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http://dx.doi.org/10.3390/jcm9061686DOI Listing

Recurrent Lethal Allergic Coronary Vasospasm.

Am J Med 2020 Jun 1. Epub 2020 Jun 1.

Department of Medicine; Division of Cardiology, University of Florida, Gainesville. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.04.037DOI Listing
June 2020
5.003 Impact Factor

Acute Coronary Syndrome with Non-ruptured Plaques (NONRUPLA): Novel Ideas and Perspectives.

Curr Atheroscler Rep 2020 May 28;22(6):21. Epub 2020 May 28.

1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, Vasilissis Sofias 114, 11528, Athens, Greece.

Purpose Of Review: In this review article, we focus on the mechanisms and features of acute coronary syndromes (ACS) with no ruptured plaque (NONRUPLA) highlighting the uncertainties over diagnostic evaluation and treatment.

Recent Findings: The most common cause of ACS is obstruction due to atherosclerotic plaque ruptured or erosion. In 14% of patients who present in the Emergency Department as myocardial infarction, the final diagnosis is ACS with NONRUPLA. Read More

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http://dx.doi.org/10.1007/s11883-020-00839-7DOI Listing

Complete AV Block Induced by Right Coronary Artery Spasm Following Radiofrequency Ablation for Atrial Fibrillation.

J Atr Fibrillation 2019 Oct-Nov;12(3):2257. Epub 2019 Oct 31.

Texas Heart Institute.

Coronary artery spasm during catheter ablation for arrhythmias is a rare but previously reported complication. Timing of presentation, manifestations of vasospasm, and purported mechanisms vary somewhat in the prior literature. We present a case of chest pain, inferior lead ST elevation, and complete AV block with angiographically confirmed right coronary artery (RCA) vasospasm that occurred immediately after catheter ablation for atrial fibrillation. Read More

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http://dx.doi.org/10.4022/jafib.2257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237099PMC
October 2019

Vasospastic Arrest:: A Heart-Stopping Case of Prinzmetal Angina.

JACC Case Rep 2020 Apr 1;2(4):611-614. Epub 2020 Apr 1.

Department of Medicine, Division of Cardiology/Electrophysiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Dr. Kim is a member of the Speakers Bureau of Boston Scientific and Medtronic.

Vasospastic angina is an uncommon cause of cardiac arrest. We describe a patient who presented with sudden cardiac arrest due to severe coronary vasospasm. Telemetry during the event revealed ventricular arrhythmias and asystole followed by spontaneous self-conversion back to normal sinus rhythm. Read More

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http://dx.doi.org/10.1016/j.jaccas.2020.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236804PMC

Vasospasm-related Sudden Cardiac Death Has Outcomes Comparable with Coronary Stenosis in Out-of-Hospital Cardiac Arrest.

J Korean Med Sci 2020 May 18;35(19):e131. Epub 2020 May 18.

Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Characteristics of coronary vasospasm-related sudden cardiac death are not well understood. We aimed to compare the characteristics and clinical outcomes between coronary vasospasm and stenosis, in out-of-hospital cardiac arrest (OHCA) survivors, who underwent coronary angiogram (CAG).

Methods: We conducted a multicenter retrospective observational registry-based study at 8 Korean tertiary care centers. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234855PMC
May 2020
1.253 Impact Factor

Diagnostic and Prognostic Value of Ergonovine Echocardiography for Noninvasive Diagnosis of Coronary Vasospasm.

JACC Cardiovasc Imaging 2020 May 8. Epub 2020 May 8.

Division of Cardiology, Asan Medical Center Heart Institute, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

Objectives: The study sought to obtain large-scale evidence supporting the clinical usefulness of ergonovine echocardiography.

Background: The role of noninvasive ergonovine provocation testing with echocardiographic monitoring of ventricular wall motion (ergonovine echocardiography) needs to be defined.

Methods: Clinical data of patients who underwent ergonovine echocardiography in 3 tertiary referral hospitals in South Korea were analyzed. Read More

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http://dx.doi.org/10.1016/j.jcmg.2020.03.008DOI Listing

ST segment elevation in an adult chest pain patient: A case of coronary artery vasospasm.

Am J Emerg Med 2020 Apr 25. Epub 2020 Apr 25.

Rochester General Hospital, Rochester, NY, United States of America.

Chest pain is one of the most common symptoms of patients presenting to the emergency department (ED) in the United States, accounting for up to eight million cases annually. We present a 55-year-old male who was brought in to the ED with sudden onset chest pain and was found to have ST-segment elevations in the infero-lateral leads on electrocardiogram (ECG). These changes resolved with nitroglycerin. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.04.066DOI Listing

Recurrent ST Elevation Myocardial Infarction from Norepinephrine-induced Coronary Vasospasm.

Cureus 2020 Apr 9;12(4):e7605. Epub 2020 Apr 9.

Cardiology/Internal Medicine, Truman Medical Center, Kansas City, USA.

Myocardial infarction with no obstructive coronary atherosclerosis (MINOCA) is a distinct clinical syndrome characterized by evidence of myocardial infarction with normal or near-normal coronary arteries on angiography (stenosis severity < 50%). Coronary artery spasm, as seen in "variant angina," usually occurs at a localized segment of an epicardial artery. Here, we present a case of a 58-year-old male who had norepinephrine-induced coronary vasospasm which resulted in ST elevation myocardial infarction on two consecutive admissions. Read More

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http://dx.doi.org/10.7759/cureus.7605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212713PMC

ST-segment elevation myocardial infarction due to multivessel, multifocal coronary vasospasm.

Coron Artery Dis 2020 May 8. Epub 2020 May 8.

Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1097/MCA.0000000000000902DOI Listing

[Myocardial infarction with nonobstructive coronary arteries].

Kardiologiia 2020 Mar 18;60(3):89-95. Epub 2020 Mar 18.

Russian National Research Medical Univercity named after N. I. Pirogov City clinical hospital #1 named after N. I. Pirogov.

The review focused on a relatively new issue, myocardial infarction with non-obstructive coronary arteries (MINOCA). According to current ideas, almost 6% of all myocardial infarction (MI) cases may be MINOCA. This term can be used both as a "working diagnosis" at the time of further evaluation and a final diagnosis after establishing a cause for each specific case. Read More

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http://dx.doi.org/10.18087/cardio.2020.3.n881DOI Listing

Coronary spastic angina in a multiple myeloma patient treated with bortezomib, lenalidomide, and dexamethasone.

J Cardiol Cases 2020 May 24;21(5):197-199. Epub 2020 Feb 24.

Department of Onco-Cardiology, Osaka International Cancer Institute, Osaka, Japan.

Adverse cardiovascular events have been reported in patients with multiple myeloma. We present a case of coronary spastic angina during combination therapy with bortezomib, lenalidomide, and dexamethasone for multiple myeloma. A 70-year-old man, newly diagnosed with multiple myeloma, was admitted to our hospital at his fifth therapy cycle due to exertional chest pain. Read More

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http://dx.doi.org/10.1016/j.jccase.2020.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195564PMC

A Challenging Combination: Anomalous Left Anterior Descending Coronary Artery, Myocardial Bridging, and Endothelial Dysfunction.

Front Cardiovasc Med 2020 15;7:57. Epub 2020 Apr 15.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States.

50 years old female patient with a medical history of hypertension presented to the clinic with chest pain, palpitations, and dyspnea on exertion of 2 years duration. Extensive workup in search of the culprit etiology of her chest pain revealed a challenging combination of an anomalous left anterior descending artery with myocardial bridging and endothelial dysfunction. She was treated medically with long acting nitrates, L-arginine and calcium channel blockers, and remains asymptomatic after 12 months of follow up. Read More

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http://dx.doi.org/10.3389/fcvm.2020.00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175789PMC

Catheter-induced Multiple Non-proximal Coronary Spasm in a Patient Presenting with Myocardial Infarction.

Cureus 2020 Mar 29;12(3):e7456. Epub 2020 Mar 29.

Cardiology, Ankara University School of Medicine, Ankara, TUR.

Interventional cardiologists encounter a wide range of lesions that cannot be angiographically distinguished from fixed atherosclerotic obstructive disease. In this case report, we document vasospasm at multiple sites in the coronary territory in a patient presenting with acute coronary syndrome. A 61-year-old woman was referred to our hospital with typical chest pain lasting approximately 1 h. Read More

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http://dx.doi.org/10.7759/cureus.7456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188002PMC

Antithrombotic Therapy of a Young Adult with Giant Left Main Coronary Artery Aneurysm.

Int Heart J 2020 May 29;61(3):601-605. Epub 2020 Apr 29.

Department of Cardiology, ZhongShan Hospital, FuDan University.

Giant coronary artery aneurysm (CAA) is a rare disorder, defined as coronary artery dilatation, in which the diameter of the coronary artery exceeds more than 1.5 times of its normal size. The most common cause of CAA is coronary atherosclerosis for adults and Kawasaki disease (KD) for children and adolescents (especially for the giant CAA that occurred in adolescence). Read More

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http://dx.doi.org/10.1536/ihj.19-451DOI Listing

Coronary Spastic Angina Induced by Adrenal Insufficiency: A Case Report.

Intern Med 2020 Apr 30. Epub 2020 Apr 30.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.

Adrenal insufficiency patients are treated with glucocorticoid replacement therapy. However, mimicking the in vivo circadian rhythm of cortisol levels is challenging, and suboptimal replacement increases the risk of mortality from cardiovascular disease. We herein report a case of coronary spastic angina (CSA) with simultaneous low early-morning serum cortisol levels in a patient undergoing corticosteroid replacement therapy for primary adrenal insufficiency. Read More

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http://dx.doi.org/10.2169/internalmedicine.4337-19DOI Listing

Dose-Response Relationship Between Intracoronary Acetylcholine and Minimal Lumen Diameter in Coronary Endothelial Function Testing of Women and Men With Angina and No Obstructive Coronary Artery Disease.

Circ Cardiovasc Interv 2020 Apr 13;13(4):e008587. Epub 2020 Apr 13.

Division of Cardiovascular Medicine, Stanford Cardiovascular Institute (V.S.P., T.N., Y.K., T.K., D.P.L., W.F.F., A.C.Y., J.A.T.), Stanford School of Medicine, CA.

Background: Intracoronary acetylcholine (Ach) provocation testing is the gold standard for assessing coronary endothelial function. However, dosing regimens of Ach are quite varied in the literature, and there are limited data evaluating the optimal dose. We evaluated the dose-response relationship between Ach and minimal lumen diameter (MLD) by sex and studied whether incremental intracoronary Ach doses given during endothelial function testing improve its diagnostic utility. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008587DOI Listing

Combined effect of left stellate ganglion blockade and topical administration of papaverine on left internal thoracic artery blood flow in patients undergoing coronary revascularization.

Ann Card Anaesth 2020 Apr-Jun;23(2):170-176

Department of CVTS, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Background: Left stellate ganglion blockade (LSGB) may have additive effect to topical administration of papaverine on prevention of vasospasm of left internal thoracic artery (LITA).

Aims: This study aims to compare LITA blood flow with topical application of papaverine alone or in combination with LSGB.

Setting: Tertiary care hospital. Read More

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http://dx.doi.org/10.4103/aca.ACA_144_18DOI Listing

Hypercalcemia-Induced ST-Segment Elevation Mimicking Acute Myocardial Injury: A Case Report and Review of the Literature.

Case Rep Emerg Med 2020 16;2020:4159526. Epub 2020 Mar 16.

Advocate Illinois Masonic Medical Center, Chicago, IL, USA.

ST-segment elevation in absence of acute coronary syndrome can be seen in multiple conditions, including acute pericarditis and coronary vasospasm, but it is rarely seen with severe hypercalcemia. The authors present a case of an 81-year-old female with a history of stage 4 squamous cell cancer of the lung, who presented to the emergency room with profound fatigue, weakness, anorexia, and drowsiness two weeks after her first chemotherapy cycle. Additionally, she had complaints of right-sided chest pain associated with worsening shortness of breath, as well as right arm numbness. Read More

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http://dx.doi.org/10.1155/2020/4159526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102466PMC

Feasibility and safety of transradial access for pediatric neurointerventions.

J Neurointerv Surg 2020 Apr 2. Epub 2020 Apr 2.

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA

Background: Diagnostic cerebral angiograms are increasingly being performed by transradial access (TRA) in adults, following data from the coronary literature supporting fewer access-site complications. Despite this ongoing trend in neuroangiography, there has been no discussion of its use in the pediatric population. Pediatric TRA has scarcely been described even for coronary or other applications. Read More

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http://dx.doi.org/10.1136/neurintsurg-2020-015835DOI Listing

Coronary Plaque Characteristics and Cut-Off Stenosis for Developing Spasm in Patients with Vasospastic Angina.

Sci Rep 2020 Mar 31;10(1):5707. Epub 2020 Mar 31.

Department of Cardiovascular Medicine, Seoul St. Mary's Hospital, The Catholic University, of Korea, Seoul, South Korea.

Coronary plaque distribution, frequency and cut-off value of percent stenosis for developing vasospasm are uncertain in patients with vasospastic angina (VA). We enrolled 2960 patients who received coronary angiography (CAG) and ergonovine provocation test prospectively in 11 university hospitals in Korea. A total of 1836 patients with VA and 867 without VA were included. Read More

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http://dx.doi.org/10.1038/s41598-020-62670-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109107PMC

Decreased Double Product at Rest in Patients with Severe Vasospasm.

Heart Lung Circ 2020 Mar 18. Epub 2020 Mar 18.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.

Background: Autonomic nerve system and endothelial function play important roles in vasospastic angina. Elevated heart rate (HR), blood pressure (BP), and double product (DP) can increase endothelial-dependent coronary artery dilation and blood flow. However, the impact of HR, BP, and DP on occurrence and severity of VSA in the clinical setting is unclear. Read More

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http://dx.doi.org/10.1016/j.hlc.2020.02.007DOI Listing

Man With Dynamic ECG Changes.

Ann Emerg Med 2020 04;75(4):518-520

Louisiana State University Health Sciences Center School of Medicine-New Orleans, Emergency Medicine Residency Program-Baton Rouge Campus, Baton Rouge, LA.

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http://dx.doi.org/10.1016/j.annemergmed.2019.05.012DOI Listing

Refractory Right Coronary Artery Spasm: A Case Report.

Cureus 2020 Feb 18;12(2):e7034. Epub 2020 Feb 18.

Cardiology, Banner - University Medical Center Phoenix, Phoenix, USA.

Herein, we report a case of severe coronary spasm during cardiac catheterization refractory to medical management. Although this condition is usually managed with vasodilating agents, our patient ultimately required placement of stents. Read More

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http://dx.doi.org/10.7759/cureus.7034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082791PMC
February 2020

Angina after anaphylaxis treatment.

Authors:
S N Leow W S Tang

Malays Fam Physician 2019 31;14(3):65-67. Epub 2019 Dec 31.

MBBS (UM), MMed (Family Medicine) UM Jalan Perak Health Clinic, Jalan Perak, 11600 Penang Malaysia.

Anaphylaxis is a life-threatening emergency, and adrenaline is the mainstay treatment for this condition. However, there have been a few reported cases of patients experiencing cardiovascular complications, such as myocardial infarction and coronary vasospasm, after its use. We highlight such a case in a young, healthy patient and the important differentials to consider. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067500PMC
December 2019

The Ulnar Artery as a Favorable Primary or Alternative Access Site for Coronary Angiography and Interventions.

Angiology 2020 May 13;71(5):417-424. Epub 2020 Mar 13.

Medical Faculty, Cardiology Department, Sakarya University, Sakarya, Turkey.

The transulnar approach (TUA) has been considered both as primary access and as a secondary access site after transradial access (TRA) failure for coronary invasive procedures. However, there is little evidence supporting the use of the TUA as the first approach to diagnostic coronary angiography (CAG) or interventions. Patients (n = 587) who underwent CAG and/or angioplasty (292 patients via TRA, 295 patients via TUA) were included. Read More

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http://dx.doi.org/10.1177/0003319720907031DOI Listing
May 2020
2.370 Impact Factor

Fluoropyrimidine-Associated Cardiotoxicity: A Retrospective Case-Control Study.

Oncologist 2020 Mar 16;25(3):e606-e609. Epub 2019 Dec 16.

Department of Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Background: The fluoropyrimidines, 5-fluorouracil (5-FU) and capecitabine, are commonly used chemotherapeutic agents that have been associated with coronary vasospasm.

Methods: In this retrospective case-control study, we identified patients at our institution who received 5-FU or capecitabine in 2018. We compared characteristics of patients who experienced cardiotoxicity with controls. Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066698PMC

Takotsubo syndrome in a heart transplant recipient with poor cardiac sympathetic reinnervation.

ESC Heart Fail 2020 Jun 10;7(3):1145-1149. Epub 2020 Mar 10.

Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

Takotsubo syndrome (TTS), also referred to as stress cardiomyopathy, is characterized by transient left ventricular apical ballooning in the absence of obstructive coronary artery disease. Catecholamine-induced cardiac injury or vasospasm has been implicated in this pathophysiology. We present a case of a 67-year-old man 10 years after heart transplantation diagnosed with TTS. Read More

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http://dx.doi.org/10.1002/ehf2.12632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261543PMC

Myocardial Infarction Secondary to Marijuana-Induced Coronary Vasospasm.

Am J Med Case Rep 2020 18;8(3):76-78. Epub 2020 Jan 18.

Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA - 11203.

With the rise of the number of states fully legalizing marijuana, the use of this substance in the United States is at an all-time high. This increasing legalization gives the impression that marijuana is rather safe. However, multiple reports by our groups and others documented serious cardiovascular complications associated with marijuana use ranging from life threatening arrhythmia to myocarditis and myocardial infarction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059731PMC
January 2020

Simultaneous Cardiotoxicity and Neurotoxicity Associated with 5-fluorouracil Containing Chemotherapy: A Case Report and Literature Review.

Am J Med Case Rep 2020 17;8(3):73-75. Epub 2020 Jan 17.

Department of Medicine, SUNY-Downstate Health Science University, 450 Clarkson Avenue, Brooklyn, New York 11203, USA.

We present a case of simultaneous cardiotoxicity and stroke-like neurotoxicity in a patient treated with FOLFOX, a 5-Fluorouracil (5-FU)-containing chemotherapy regimen. Within hours of FOLFOX infusion, the patient began to exhibit signs and symptoms of myocardial ischemia and stroke mimic. Coronary vasoconstriction and vasospasm is a known mechanism of 5-FU-induced cardiotoxicity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059734PMC
January 2020

Coronary Artery Anomaly in Takotsubo Cardiomyopathy: Cause or Innocent Bystander?

Tex Heart Inst J 2020 02 1;47(1):44-46. Epub 2020 Feb 1.

Coronary artery anomalies can provoke intermittent vasospasm and endothelial dysfunction, which can cause takotsubo cardiomyopathy. However, in takotsubo cardiomyopathy, apical myocardial regions are typically affected, and these do not correlate with a specific epicardial coronary distribution territory. We report the case of a 74-year-old woman who presented with acute respiratory failure and suspected myocardial infarction. Read More

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http://dx.doi.org/10.14503/THIJ-18-6809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046363PMC
February 2020

Is there a role for remote ischemic conditioning in preventing 5-fluorouracil-induced coronary vasospasm?

Cond Med 2019 Oct;2(5):204-212

National Heart Centre Singapore, Singapore.

Cardiac ischemia associated with chemotherapy has been linked to several anti-neoplastic agents and is multifactorial in etiology. Coronary artery vasospasm is one of the most commonly reported effects of cancer therapy that can lead to myocardial ischemia or infarction. The chemotherapy agent 5-fluorouracil (5-FU) or its oral pro-drug capecitabine can result in coronary vascular endothelial dysfunction causing coronary artery spasm, and possibly coronary thrombosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055861PMC
October 2019

Death of an apprentice bodybuilder following 2,4-dinitrophenol and clenbuterol intake.

Int J Legal Med 2020 May 3;134(3):1003-1006. Epub 2020 Mar 3.

Institut Médico-Légal, Paris, France.

We present the case of a 17-year-old man, who died after 2,4-dinitrophenol (DNP) and clenbuterol consumption, which he likely took for physical enhancement. Forensic post-mortem examination revealed a yellowish skin colour and nonspecific signs of asphyxia. Analytical confirmation of the intoxication was obtained in blood and urine, with high levels of DNP and clenbuterol. Read More

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http://dx.doi.org/10.1007/s00414-020-02268-2DOI Listing

A rare case of atropine-resistant bradycardia following sugammadex administration.

JA Clin Rep 2020 Mar 2;6(1):18. Epub 2020 Mar 2.

Department of Anesthesiology, Kansai Medical University Hospital, 2-3-1 Shin-machi, Hirakata-city, Osaka, 573-1191, Japan.

Background: Profound bradycardia caused by sugammadex has been reported, although its mechanism is unclear. Herein, we suggest a possible culprit for this phenomenon.

Case Presentation: A 50-year-old woman without comorbidity except mild obesity underwent a transabdominal hysterectomy and right salpingo-oophorectomy. Read More

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http://dx.doi.org/10.1186/s40981-020-00326-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052100PMC

ST Elevations and Ventricular Tachycardia Secondary to Coronary Vasospasm upon Extubation.

Case Rep Anesthesiol 2020 12;2020:1527345. Epub 2020 Feb 12.

Department of Anesthesia Critical Care and Pain, Massachusetts General Hospital, Boston, Massachusetts, USA.

ST elevations (STE) in the perioperative setting can result from a number of different etiologies, the most common and feared being acute coronary syndrome (ACS). However, other causes should be considered, as treatment may differ depending on the diagnosis. Here, we describe a case of STE and ventricular tachycardia in a patient at high risk for ACS. Read More

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http://dx.doi.org/10.1155/2020/1527345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037527PMC
February 2020

Comparison of calcium-channel blockers for long-term clinical outcomes in patients with vasospastic angina.

Korean J Intern Med 2020 Feb 24. Epub 2020 Feb 24.

Department of Cardiovascular Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background/aims: Calcium channel blockers (CCBs) are the most widely prescribed medication for patients with vasospastic angina (VA). However, few studies have compared the prognosis of VA patients who are prescribed different CCBs.

Methods: We enrolled 2,960 patients who received provocation test prospectively in 11 university hospitals in Korea. Read More

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http://dx.doi.org/10.3904/kjim.2019.308DOI Listing
February 2020

Imaging Integration to Localize and Protect the Left Coronary Artery in Patients Undergoing LAAEI.

JACC Clin Electrophysiol 2020 02 27;6(2):157-167. Epub 2019 Nov 27.

Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; Texas Cardiac Arrhythmia Institute at St. David's Medical Center, Austin, Texas. Electronic address:

Objectives: This study sought to determine the distance between the anterior wall of the left atrial appendage (LAA) ostium to the left main coronary artery (LMCA) and the left circumflex artery (LCx) in patients undergoing left atrial appendage electrical isolation (LAAEI).

Background: LAAEI improves outcomes in nonparoxysmal atrial fibrillation ablation. There is a potential risk of damaging the LMCA and the LCx during LAAEI. Read More

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http://dx.doi.org/10.1016/j.jacep.2019.09.011DOI Listing
February 2020

Sudden cardiac arrest due to coronary vasospasm in a patient with Wolff-Parkinson-White syndrome during brain surgery: a case report.

JA Clin Rep 2019 Feb 28;5(1):13. Epub 2019 Feb 28.

Department of Anesthesiology and Reanimatology, Faculty of Medicine Sciences, University of Fukui, 23-3 Eiheijicho, Yoshidagun, Fukui, 910-1193, Japan.

Background: Wolff-Parkinson-White (WPW) syndrome has the risk of sudden cardiac death. Without appropriate treatment, coronary vasospasm is also a potentially fatal condition due to ischemia-induced ventricular fibrillation. A rare case of cardiac arrest due to coronary vasospasm during general anesthesia in a patient with pre-existing WPW syndrome is presented. Read More

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http://dx.doi.org/10.1186/s40981-019-0233-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967257PMC
February 2019

Distal radial artery access in the anatomical snuffbox for coronary angiography and intervention: A single center experience.

Medicine (Baltimore) 2020 Jan;99(3):e18330

Department of Cardiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University.

Background: To explore the feasibility and safety of coronary angiography (CAG) and percutaneous coronary intervention (PCI) via the distal radial artery in the anatomical snuffbox.

Methods: Ninety two patients who underwent CAG or PCI through distal radial artery access at The Second Affiliated Hospital of Zhejiang Chinese Medical University from September 2017 to March 2018 were included in our study. We collected baseline characteristics, number, and duration of arterial punctures, procedural success rate, postoperative compression time, the numerical rating scale (NRS) scores at 3 hours after procedure, complications, hospitalization duration. Read More

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http://dx.doi.org/10.1097/MD.0000000000018330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220134PMC
January 2020

Coronary vasospasm induced by cisplatin for seminoma.

Clin Case Rep 2020 Jan 19;8(1):190-193. Epub 2019 Dec 19.

Division of Cardiovascular Medicine Saitama Medical Center Jichi Medical University Saitama Japan.

Vascular toxicity is one of serious complications following cisplatin-based chemotherapy. This case suggests that cisplatin has a potential risk of delayed occurrence of vasospastic angina. It is important to perform careful history taking including discontinued drugs for differential diagnosis of chest pain. Read More

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http://dx.doi.org/10.1002/ccr3.2601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982474PMC
January 2020

Management of Angina Post Percutaneous Coronary Intervention.

Curr Cardiol Rep 2020 Jan 21;22(2). Epub 2020 Jan 21.

Division of Cardiovascular Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.

Purpose Of Review: Our review discusses the management of post percutaneous coronary intervention angina (PPCIA) which negatively impacts 20-40% of patients and imposes a high burden on the healthcare system.

Recent Findings: Mechanisms of PPCIA include microvascular dysfunction, distal coronary vasospasm or disease, microembolization, myocardial bridge, coronary artery disease (CAD) progression, and rarely stent thrombosis or in-stent restenosis. Nitrates, beta blockers (BB), calcium channel blockers, and ranolazine are the common medical management options. Read More

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http://dx.doi.org/10.1007/s11886-020-1259-9DOI Listing
January 2020

Acute Myocardial Infarction Caused by Coronary Spasm and Dissection Treated with Medical Therapy.

Int Heart J 2020 Jan 17;61(1):169-173. Epub 2020 Jan 17.

Department of Cardiology, Tokyo Women's Medical University, Yachiyo Medical Center.

We report the case of a 33-year-old woman with no history of coronary risk factors or chest pain who experienced intermittent chest pain at rest for several minutes from 2 PM. At 8 AM the next day, chest pain recurred and persisted for about 1 hour. She was transported to our hospital by ambulance, where electrocardiogram showed ST-elevation in the precordial leads, and blood tests showed elevation of cardiac markers. Read More

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http://dx.doi.org/10.1536/ihj.19-319DOI Listing
January 2020

Acute Upper-Limb Complications Following Radial Artery Catheterization for Coronary Angiography.

J Hand Surg Am 2020 Jul 8;45(7):655.e1-655.e5. Epub 2020 Jan 8.

Department of Plastic Surgery, Mayo Clinic, Rochester, MN. Electronic address:

Purpose: The radial artery is becoming the vessel of choice for performing cardiac catheterization. Transradial catheterization can impose risks on the upper extremity, and hand surgeons should be aware of the most frequent complications. The purpose of this study was to determine the frequency, timing, and scope of upper-limb complications shortly after transradial catheterization. Read More

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http://dx.doi.org/10.1016/j.jhsa.2019.11.007DOI Listing

Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Function and CT Coronary Angiogram (CorCTCA) study.

Am Heart J 2020 03 2;221:48-59. Epub 2019 Dec 2.

West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address:

Microvascular and/or vasospastic anginas are relevant causes of ischemia with no obstructive coronary artery disease (INOCA) in patients after computed tomography coronary angiography (CTCA).

Objectives: Our research has 2 objectives. The first is to undertake a diagnostic study, and the second is to undertake a nested, clinical trial of stratified medicine. Read More

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http://dx.doi.org/10.1016/j.ahj.2019.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029345PMC