160,185 results match your criteria Coronary Artery Atherosclerosis


Chest pain with less than 20% change in high sensitivity troponin T - a low risk cohort?

Acta Cardiol 2019 Jan 16:1-7. Epub 2019 Jan 16.

c Cardiology Department , University Hospital Monklands , Lanarkshire , Scotland.

Background: Patients with chest pain are risk-stratified using serial high-sensitivity troponin (T) assays (hsTnT). Those with change in (Δ)hsTnT <20% are often categorised as low-risk and are less likely to be managed as acute coronary syndromes (ACS). We sought to characterise such a population of 'low-risk' chest pain presenters. Read More

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http://dx.doi.org/10.1080/00015385.2018.1561598DOI Listing
January 2019

Diagnostic value of peak filling rate derived from ECG-gated myocardial perfusion SPECT for detecting myocardial ischaemia in patients with non-obstructive coronary artery disease.

Acta Cardiol 2019 Jan 16:1-5. Epub 2019 Jan 16.

a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Minami-ku , Hiroshima , Japan.

Background: Left ventricular (LV) diastolic dysfunction represents an earlier step of the ischaemic cascade. We tested the hypothesis that the index of LV diastolic function from electrocardiogram (ECG)-gated single photon emission computed tomography (SPECT) is useful in detecting myocardial ischaemia in patients with non-obstructive coronary artery disease (CAD).

Methods: One-hundred-ten patients with non-obstructive CAD and summed redistribution score of zero were enrolled. Read More

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http://dx.doi.org/10.1080/00015385.2018.1544698DOI Listing
January 2019

Established coronary artery disease in systemic sclerosis compared to type 2 diabetic female patients: a cross-sectional study.

Clin Rheumatol 2019 Jan 16. Epub 2019 Jan 16.

Rheumatology Unit, Azienda Ospedaliero-Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy.

Introduction: Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction, which is also associated with other disorders, such as atherosclerosis. The direct role of SSc in facilitating cardiovascular events should be clarified. We compared the prevalence of established coronary artery disease (CAD) between SSc and type 2 diabetes, a well-known phenotype associated with high cardiovascular risk. Read More

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http://dx.doi.org/10.1007/s10067-019-04427-2DOI Listing
January 2019

Clinical Outcomes, Pharmacologic Treatment and Quality of Life of Patients with Stable Coronary Artery Diseases Managed by Cardiologists: 1-Year Results of the START Study.

Eur Heart J Qual Care Clin Outcomes 2019 Jan 14. Epub 2019 Jan 14.

Division of Cardiology, Garibaldi-Nesima Hospital, Catania, Italy.

Aims: We evaluated the 1-year clinical events, pharmacologic management and quality of life in a contemporary cohort of stable coronary artery disease (CAD) patients managed by cardiologists.

Methods And Results: START (STable Coronary Artery Diseases RegisTry) was a prospective, observational, nationwide study that enrolled 5070 stable CAD patients over 3 months in 183 cardiology centers in Italy. At 1 year, 4790 (94. Read More

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http://dx.doi.org/10.1093/ehjqcco/qcz002DOI Listing
January 2019

Is restricted use of bilateral internal mammary artery grafting strategy ideal for multivessel coronary artery disease?

Eur J Cardiothorac Surg 2019 Jan 14. Epub 2019 Jan 14.

Department of Cardiothoracic Surgery, Star Hospitals, Hyderabad, India.

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http://dx.doi.org/10.1093/ejcts/ezy467DOI Listing
January 2019

Burden and causes for hospitalizations following coronary artery bypass grafting: a nationwide cohort study.

Eur J Cardiothorac Surg 2019 Jan 10. Epub 2019 Jan 10.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Hospitalizations are a major burden for both patients and society and are potentially preventable. However, data on the burden and causes for hospitalizations after coronary artery bypass grafting (CABG) are sparse. We examined hospitalizations within 1 year after CABG and associated factors. Read More

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http://dx.doi.org/10.1093/ejcts/ezy418DOI Listing
January 2019

Subclinical coronary atherosclerosis and cardiovascular risk stratification in heterozygous familial hypercholesterolemia patients undergoing statin treatment.

Curr Opin Lipidol 2019 Jan 14. Epub 2019 Jan 14.

Heart Institute (InCor) University of Sao Paulo Medical School Hospital.

Purpose Of Review: To discuss the heterogeneity of atherosclerotic cardiovascular disease (ASCVD) risk in heterozygous familial hypercholesterolemia and evidence and limitations of clinical risk scores and subclinical coronary atherosclerosis (SCA) imaging to evaluate risk.

Recent Findings: Risk evaluation in contemporary familial hypercholesterolemia cohorts needs to consider the cause of the familial hypercholesterolemia phenotype, for example the presence of autosomal molecular defects that impart a greater ASCVD risk than in polygenic hypercholesterolemia, prospective follow-up and the impact of statin treatment. As atherosclerosis is multifactorial, clinical scores like the Montreal familial hypercholesterolemia score and SAFEHEART risk equation have been proposed to stratify ASCVD in statin-treated, molecularly defined familial hypercholesterolemia individuals. Read More

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http://dx.doi.org/10.1097/MOL.0000000000000573DOI Listing
January 2019

First International Consensus on the diagnosis and management of fibromuscular dysplasia.

Vasc Med 2019 Jan 16:1358863X18821816. Epub 2019 Jan 16.

6 Paris Descartes University, Paris, France.

This article is a comprehensive document on the diagnosis and management of fibromuscular dysplasia (FMD), which was commissioned by the working group 'Hypertension and the Kidney' of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). This document updates previous consensus documents/scientific statements on FMD published in 2014 with full harmonization of the position of European and US experts. In addition to practical consensus-based clinical recommendations, including a consensus protocol for catheter-based angiography and percutaneous angioplasty for renal FMD, the document also includes the first analysis of the European/International FMD Registry and provides updated data from the US Registry for FMD. Read More

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http://dx.doi.org/10.1177/1358863X18821816DOI Listing
January 2019

Endovascular approach in chronic aortoiliac disease in patient undergoing coronary artery bypass surgery.

Ann Card Anaesth 2019 Jan-Mar;22(1):96-97

Department of Cardiothoracic Surgery, General Hospital "G. Papanikolaou," Thessaloniki, Greece.

Internal thoracic artery (ITA) is an excellent conduit for coronary artery bypass surgery (CABG). We present a patient with known preoperative aortoiliac disease with anterior collateral pathway who had an indication for elective coronary bypass. The use of ITA in these patients may cause lower limb ischemia. Read More

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http://dx.doi.org/10.4103/aca.ACA_60_18DOI Listing
January 2019

Off-pump coronary bypass grafting in a post-pneumonectomy patient: Challenges and management.

Ann Card Anaesth 2019 Jan-Mar;22(1):86-88

Department of Cardiac Anaesthesia, Fortis Memorial Research Institute, Gurgaon, Haryana, India.

Pulmonary complications are common in cardiac surgical patients. Limited respiratory reserves along with the pain associated with sternotomy add to the morbidity. Patients undergoing cardiac surgery who have had a pneumonectomy done before can be even more challenging to manage perioperatively due to a single-functioning lung. Read More

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http://dx.doi.org/10.4103/aca.ACA_37_18DOI Listing
January 2019

Associations of metabolically healthy obesity with prevalence and progression of coronary artery calcification: Results from the Heinz Nixdorf Recall Cohort Study.

Nutr Metab Cardiovasc Dis 2018 Nov 15. Epub 2018 Nov 15.

Center of Clinical Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University Duisburg-Essen, Essen, Germany; School of Public Health, Department of Epidemiology, Boston University, 715 Albany, Street, Talbot Building, Boston, MA 02118, USA.

Background And Aims: There is controversy on the potentially benign nature of metabolically healthy obesity (MHO), i.e., obese persons with few or no metabolic abnormalities. Read More

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http://dx.doi.org/10.1016/j.numecd.2018.11.002DOI Listing
November 2018

Microsurgical head and neck reconstruction in patients with coronary artery disease: A perioperative assessment algorithm.

Microsurgery 2019 Jan 15. Epub 2019 Jan 15.

Department of Plastic and Reconstructive Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: With the rising number of patients in advanced age receiving microsurgical procedures, coronary artery disease (CAD) and its challenging management is of increasing importance. Evidence based data concerning morbidity and mortality are rare. We present our experiences with this highly selected patient population and propose a preoperative assessment algorithm. Read More

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http://dx.doi.org/10.1002/micr.30429DOI Listing
January 2019

Heart rate reserve during pharmacological stress is a significant negative predictor of impaired coronary flow reserve in women.

Eur J Nucl Med Mol Imaging 2019 Jan 16. Epub 2019 Jan 16.

Department of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Purpose: Evidence to date has failed to adequately explore determinants of cardiovascular risk in women with coronary microvascular dysfunction (CMVD). Heart rate responses to adenosine mirror autonomic activity and may carry important prognostic information for the diagnosis of CMVD.

Methods: Hemodynamic changes during adenosine stress were analyzed in a propensity-matched cohort of 404 patients (202 women, mean age 65. Read More

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http://dx.doi.org/10.1007/s00259-019-4265-7DOI Listing
January 2019

Effect of Potent P2Y Inhibitors on Ventricular Arrhythmias and Cardiac Dysfunction in Coronary Artery Disease: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 17;2018:8572740. Epub 2018 Dec 17.

Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background: Previous studies have shown that P2Y receptor inhibitors might prevent ventricular arrhythmias and cardiac dysfunction in patients with coronary artery disease. However, few studies have focused on comparison of the efficacy of novel oral potent P2Y receptor inhibitors with clopidogrel on these outcomes.

Methods And Results: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) that were published in electronic databases of MEDLINE, EMBASE, Cochrane Central Register of Clinical Trials, and ClinicalTrials. Read More

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http://dx.doi.org/10.1155/2018/8572740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311824PMC
December 2018

Unusual Sequence of Events in a Case of Takotsubo Syndrome.

Case Rep Cardiol 2018 13;2018:5498052. Epub 2018 Dec 13.

Department of Cardiology, Maimonides Medical Center, Brooklyn, NY 11219, USA.

A 73-year-old female with multiple comorbidities including coronary artery disease was admitted for an elective PCI of a lesion detected in the RCA. On the day of the planned PCI, shortly after right femoral artery cannulation, the patient developed a sudden complete heart block requiring the administration atropine and insertion of a temporary pacemaker. Concomitantly, the patient developed acute pulmonary edema, hypotension, and hypoxia requiring intubation for mechanical ventilation. Read More

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http://dx.doi.org/10.1155/2018/5498052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311793PMC
December 2018

ST Segment Elevation and Depressions in Supraventricular Tachycardia without Coronary Artery Disease.

Case Rep Cardiol 2018 13;2018:2716312. Epub 2018 Dec 13.

University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

ST segment changes are well documented in literature during supraventricular tachycardias. We present a case of a 21-year-old male who presents with chest pain, shortness of breath, and dizziness with an ECG showing atrioventricular reentrant tachycardia and diffuse ST segment depressions. Patient spontaneously converted to sinus rhythm, but he was still complaining of crushing chest pain. Read More

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http://dx.doi.org/10.1155/2018/2716312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311840PMC
December 2018

Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease.

J Nutr Metab 2018 11;2018:6104169. Epub 2018 Dec 11.

Laboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Brazil.

: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression of atherosclerosis. This study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with the extent of coronary lesions in patients with coronary artery disease. . Read More

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http://dx.doi.org/10.1155/2018/6104169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311864PMC
December 2018

Oxidative Stress in Cardiac Tissue of Patients Undergoing Coronary Artery Bypass Graft Surgery: The Effects of Overweight and Obesity.

Oxid Med Cell Longev 2018 17;2018:6598326. Epub 2018 Dec 17.

Center for Cardiology/Cardiology 1, Laboratory of Molecular Cardiology of the Johannes Gutenberg University, Mainz, Germany.

Background: Obesity is one of the major cardiovascular risk factors and is associated with oxidative stress and myocardial dysfunction. We hypothesized that obesity affects cardiac function and morbidity by causing alterations in enzymatic redox patterns.

Methods: Sixty-one patients undergoing coronary artery bypass grafting (CABG) were included in the study. Read More

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http://dx.doi.org/10.1155/2018/6598326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311809PMC
December 2018

Differential Associations for Salivary Sodium, Potassium, Calcium, and Phosphate Levels with Carotid Intima Media Thickness, Heart Rate, and Arterial Stiffness.

Dis Markers 2018 16;2018:3152146. Epub 2018 Dec 16.

INSERM U1116, Université de Lorraine, Nancy, France.

Salivary biomarkers may offer a noninvasive and easy sampling alternative in cardiovascular risk evaluation. The aim of the present study was to establish associations of salivary potassium, sodium, calcium, and phosphate levels with the cardiovascular phenotype determined by carotid ultrasound and carotid-femoral pulse wave velocity and to identify possible covariates for these associations. = 241 samples of nonstimulated whole buccal saliva were obtained from subjects with ( = 143; 59%) or without ( = 98; 41%) hypertension. Read More

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http://dx.doi.org/10.1155/2018/3152146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311732PMC
December 2018

In-hospital outcome of patients with post-MI VSD: a single-center study.

Kardiochir Torakochirurgia Pol 2018 Dec 31;15(4):227-232. Epub 2018 Dec 31.

Department of Cardiology, Tabriz University of Medical Science, Tabriz, Iran.

Introduction: Ventricular septal defect (VSD) is a rare but life-threatening complication of acute myocardial infarction (AMI). There is a paucity of data regarding the natural history of this devastating complication of myocardial infarction in the Middle East region with restricted financial resources and unsolved major health problems.

Aim: To evaluate the clinical presentation and in-hospital outcome of patients with post-infarction VSD over a 10-year period in a tertiary center in northwest Iran. Read More

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http://dx.doi.org/10.5114/kitp.2018.80918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329881PMC
December 2018

Coronary endarterectomy: an old tool for patients currently operated on with coronary artery bypass grafting. Long-term results, risk factor analysis.

Kardiochir Torakochirurgia Pol 2018 Dec 31;15(4):219-226. Epub 2018 Dec 31.

Department of Cardiac Surgery, Tor Vergata University Policlinic, Rome, Italy.

Aim: Coronary endarterectomy (CE) may provide a useful adjunctive technique to coronary artery bypass grafting (CABG) in patients with diffuse coronary artery disease. Nevertheless, the incidence of complications still remains high, long-term results remain unclear, and no risk factors for late mortality have been completely described yet.

Material And Methods: We retrospectively reviewed 90 consecutive patients (67 ±8. Read More

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http://dx.doi.org/10.5114/kitp.2018.80917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329878PMC
December 2018

Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus.

J Genet Eng Biotechnol 2017 Dec 8;15(2):409-414. Epub 2017 Aug 8.

Department of Clinical and Chemical Pathology, National Institute of Diabetes and Endocrinology, Cairo, Egypt.

Objective: Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene is one of the possible genes linking diabetes mellitus (DM) with coronary artery disease (CAD). The aim of this study is to clarify whether PPAR-γ Pro12Ala polymorphism is associated with the development of CAD in type 2 diabetic patients and to evaluate PPAR-γ Pro12Ala polymorphism genetic distribution in type 2 DM (T2DM) Egyptian subjects.

Methods: PPAR-γ Pro12Ala polymorphism was determined by Real-Time PCR in serum of 405 subjects classified into 4 groups; T2DM patients (n = 105), T2DM with CAD (n = 100), CAD patients (n = 100) and healthy controls (n = 100). Read More

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http://dx.doi.org/10.1016/j.jgeb.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296640PMC
December 2017

Cost-effectiveness analysis of pharmacogenomics-guided clopidogrel treatment in Spanish patients undergoing percutaneous coronary intervention.

Pharmacogenomics J 2019 Jan 16. Epub 2019 Jan 16.

The Golden Helix Foundation, London, UK.

Clopidogrel is an antiplatelet drug given to patients before and after having a percutaneous coronary intervention (PCI). Genomic variants in the CYP2C19 gene are associated with variable enzyme activities affecting drug metabolism and hence, patients with reduced or increased enzymatic function have increased risk of bleeding. We conducted a cost-effectiveness analysis to compare a pharmacogenomics versus a non-pharmacogenomics-guided clopidogrel treatment for coronary artery syndrome patients undergoing PCI in the Spanish healthcare setting. Read More

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http://www.nature.com/articles/s41397-019-0069-1
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http://dx.doi.org/10.1038/s41397-019-0069-1DOI Listing
January 2019
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Disease Damage Influences Cardiovascular Risk Reclassification Based on Carotid Ultrasound in Patients with Systemic Lupus Erythematosus.

J Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

From the Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife; Division of Rheumatology, Hospital Insular, Las Palmas de Gran Canaria; Central Laboratory Division, Hospital Universitario de Canarias, Tenerife; Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Investigacíon Sanitaria (IDIVAL); Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; School of Medicine, University of Cantabria, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. This work was supported by a grant to IFA from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional - FEDER - (Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay's research was supported by European Union FEDER funds and by the Fondo de Investigación Sanitaria (grants PI06/0024, PS09/00748, PI12/00060 and PI15/00525) of the Instituto de Salud Carlos III (ISCIII, Health Ministry, Spain). It was also partially supported by RETICS Programs RD12/0009 (RIER), RD12/0009/0013, and RD16/0012 from the Instituto de Salud Carlos III (ISCIII, Health Ministry, Spain). J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín; I. Rúa-Figueroa, MD, PhD, Division of Rheumatology, Hospital Doctor Negrín; H. Sánchez-Pérez, MD, Division of Rheumatology, Hospital Universitario de Canarias; B. Tejera-Segura, MD, Division of Rheumatology, Hospital Insular; A. de Vera-González, MD, Central Laboratory Division, Hospital Universitario de Canarias; A. González-Delgado, MD, Central Laboratory Division, Hospital Universitario de Canarias; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBERESP, IDIVAL; M.A. González-Gay, MD, PhD, Division of Rheumatology, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro shared senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain. E-mail: Accepted for publication September 21, 2018.

Objective: Composite scores of cardiovascular (CV) risk factors underestimate the CV risk in patients with systemic lupus erythematosus (SLE). Carotid artery ultrasound (US) was found useful in identifying high CV-risk patients with inflammatory arthritis. We assessed the effect of carotid US assessments on the CV risk stratification of patients with SLE. Read More

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http://dx.doi.org/10.3899/jrheum.180881DOI Listing
January 2019

Cardiovascular outcomes among elderly patients with heart failure and coronary artery disease and without atrial fibrillation: a retrospective cohort study.

BMC Cardiovasc Disord 2019 Jan 15;19(1):19. Epub 2019 Jan 15.

New York University School of Medicine, New York, NY, USA.

Background: Coronary artery disease accelerates heart failure progression, leading to poor prognosis and a substantial increase in morbidity and mortality. This study was aimed to assess the impact of coronary artery disease on all-cause mortality, myocardial infarction (MI), and ischemic stroke (IS) among hospitalized newly-diagnosed heart failure (HF) patients with left ventricular systolic dysfunction (LVSD).

Methods: This retrospective cohort study included Medicare patients (aged ≥65 years) with ≥1 inpatient heart failure claim (index date = discharge date) during 01JAN2007-31DEC2013. Read More

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https://bmccardiovascdisord.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12872-018-0991-1DOI Listing
January 2019
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Thrombotic/Thrombolytic Balance as a Cardiac Treatment Determinant in Patients With Diabetes Mellitus and Coronary Artery Disease.

J Am Heart Assoc 2019 Jan;8(2):e011207

1 Department of Diabetes, Endocrinology, and Metabolism Center Hospital National Center for Global Health and Medicine Tokyo Japan.

Background This study aimed to assess whether the plasminogen activator inhibitor-1/tissue plasminogen activator ( PAI -1/ tPA ) ratio as a prothrombotic state is useful for optimizing cardiac treatment strategy. Methods and Results Using BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial data, we used a Cox proportional hazard model to calculate hazard ratios with 95% CI s for cardiac events in patients receiving early revascularization (percutaneous coronary intervention or coronary artery bypass grafting) or medical therapy, separately in patients with low (n=1276) and high (n=894) PAI -1/ tPA ratios. The primary outcome was major cardiac events, which was a composite end point including cardiac death and nonfatal myocardial infarction. Read More

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http://dx.doi.org/10.1161/JAHA.118.011207DOI Listing
January 2019

Not Just Arterial Damage: Increased Incidence of Venous Thromboembolic Events in Cardiovascular Patients With Elevated Plasma Levels of Apolipoprotein CIII.

J Am Heart Assoc 2019 Jan;8(2):e010973

1 Unit of Internal Medicine Department of Medicine University of Verona Italy.

Background Apolipoprotein CIII (apo CIII ) is a crucial player in triglyceride-rich lipoprotein metabolism, but may also act pleiotropically, provoking inflammatory responses and stimulating coagulation. Elevated apo CIII plasma levels have been associated with increased activity of coagulation factors. Since these features of prothrombotic diathesis are linked with venous thromboembolism ( VTE ), we hypothesized that apo CIII plays a role in VTE . Read More

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http://dx.doi.org/10.1161/JAHA.118.010973DOI Listing
January 2019

Discrimination between Obstructive Coronary Artery Disease and Cardiac Syndrome X in Women with Typical Angina and Positive Exercise Test; Utility of Cardiovascular Risk Calculators.

Medicina (Kaunas) 2019 Jan 14;55(1). Epub 2019 Jan 14.

Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran.

Nearly 40% of women with typical angina and a positive exercise tolerance test (ETT) have normal or near normal coronary angiography (CAG) labeled as cardiac syndrome X (CSX). We performed this study to evaluate the power of common cardiovascular risk calculators to distinguish patients with CSX from those with coronary artery disease (CAD). 559 women participated in the study. Read More

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http://dx.doi.org/10.3390/medicina55010012DOI Listing
January 2019

Polyvascular Disease and Risk of Major Adverse Cardiovascular Events in Peripheral Artery Disease: A Secondary Analysis of the EUCLID Trial.

JAMA Netw Open 2018 Nov 2;1(7):e185239. Epub 2018 Nov 2.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.

Importance: The effect of polyvascular disease on cardiovascular outcomes in the background of peripheral artery disease (PAD) is unclear.

Objective: To determine the risk of ischemic events (both cardiac and limb) among patients with PAD and polyvascular disease.

Design, Setting, And Participants: In this post hoc secondary analysis of the international Examining Use of Ticagrelor in Peripheral Artery Disease (EUCLID) trial, outcomes were compared among 13 885 enrolled patients with PAD alone, PAD + coronary artery disease (CAD), PAD + cerebrovascular disease (CVD), and PAD + CAD + CVD. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.5239DOI Listing
November 2018
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Association Between Obesity and Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Mendelian Randomization Studies.

JAMA Netw Open 2018 Nov 2;1(7):e183788. Epub 2018 Nov 2.

Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio.

Importance: Although dyslipidemia has been consistently shown to be associated with atherogenesis, an association between obesity and cardiovascular disease outcomes remains controversial. Mendelian randomization can minimize confounding if variables are randomly and equally distributed in the population of interest.

Objective: To assess evidence from mendelian randomization studies to provide a less biased estimate of any association between obesity and cardiovascular outcomes. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.3788DOI Listing
November 2018

Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction in China: Results From the China PEACE Prospective Study of Percutaneous Coronary Intervention.

JAMA Netw Open 2018 Dec 7;1(8):e185446. Epub 2018 Dec 7.

National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Importance: Despite a rapid increase in percutaneous coronary intervention (PCI) procedures in China, little is known about patient-reported health status before and after PCI in patients without acute myocardial infarction (AMI).

Objective: To describe self-perceived angina-specific health status prior to PCI and 1 year after the procedure in patients without AMI in China.

Design, Setting, And Participants: The China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE) Prospective Study of PCI was a population-based, multicenter cohort study of a consecutive sample of 1611 patients without AMI undergoing elective PCI. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2018.5446DOI Listing
December 2018
1 Read

Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing.

JAMA Netw Open 2018 Oct 5;1(6):e183605. Epub 2018 Oct 5.

Cleveland Clinic Foundation, Cleveland, Ohio.

Importance: Adverse cardiovascular findings associated with habitual vigorous exercise have raised new questions regarding the benefits of exercise and fitness.

Objective: To assess the association of all-cause mortality and cardiorespiratory fitness in patients undergoing exercise treadmill testing.

Design, Setting, And Participants: This retrospective cohort study enrolled patients at a tertiary care academic medical center from January 1, 1991, to December 31, 2014, with a median follow-up of 8. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.3605DOI Listing
October 2018

Cardiovascular Disease Among Women Who Gave Birth to an Infant With a Major Congenital Anomaly.

JAMA Netw Open 2018 Sep 7;1(5):e182320. Epub 2018 Sep 7.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Importance: Having a child with a major birth defect can be a life-changing and stressful event that may be associated with higher cardiovascular disease (CVD) risk, yet the long-term burden of CVD for the child's mother is unknown.

Objective: To assess whether mothers of an infant born with a major congenital anomaly are at higher risk of CVD compared with a comparison cohort.

Design, Setting, And Participants: A population-based cohort study using individual-level linked registry data in Denmark included 42 943 women who gave birth to an infant with a major congenital anomaly between January 1, 1979, and December 31, 2013; and follow-up was conducted until 2015. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.2320DOI Listing
September 2018
2 Reads

Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction.

JAMA Netw Open 2018 Aug 3;1(4):e181456. Epub 2018 Aug 3.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.

Importance: Clinical decisions are frequently based on measurement of left ventricular ejection fraction (LVEF). Limited information exists regarding inconsistencies in LVEF measurements when determined by various imaging modalities and the potential impact of such variability.

Objective: To determine the intermodality variability of LVEF measured by echocardiography, gated single-photon emission computed tomography (SPECT), and cardiovascular magnetic resonance (CMR) in patients with left ventricular dysfunction. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.1456DOI Listing

Temporal trends in prevalence and antithrombotic treatment among Asians with atrial fibrillation undergoing percutaneous coronary intervention: A nationwide Korean population-based study.

PLoS One 2019 15;14(1):e0209593. Epub 2019 Jan 15.

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom.

Background: We investigated the recent 10-year trends in the number of patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) in relation to prescription patterns of antithrombotic therapy.

Methods: We analyzed the annual prevalence of PCI and patterns of antithrombotic therapy after PCI, including antiplatelets and oral anticoagulants (vitamin K antagonists and non-vitamin K antagonist oral anticoagulants [NOACs]), in patients with AF between 2006 and 2015 by using the Korean National Health Insurance Service database. Independent factors associated with triple therapy (oral anticoagulant plus dual antiplatelet) prescription were assessed using multivariable logistic regression analysis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209593PLOS
January 2019

Vascular imaging findings with high-pitch low-dose dual-source CT in atypical Kawasaki disease.

Diagn Interv Radiol 2019 Jan;25(1):50-54

Department of Radiology, Atatürk University School of Medicine, Erzurum, Turkey.

Purpose: Determining the presence of aneurysms, thrombosis, and stenosis is very important for the diagnosis of atypical Kawasaki disease (AKD) and in the follow-up of AKD patients with aneurysms. We aimed to demonstrate high-pitch low-dose dual-source computed tomography (CT) angiography findings in pediatric patients with AKD.

Methods: Over a 5-year period, high-pitch low-dose CT angiography was performed to determine vascular aneurysms or occlusions in 17 patients who had suspected AKD. Read More

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http://dx.doi.org/10.5152/dir.2018.18092DOI Listing
January 2019

Left ventricular contractile reserve in stress echocardiography: the bright side of the force.

Kardiol Pol 2019 Jan 15. Epub 2019 Jan 15.

Institute of Clinical Physiology, National Council Research, Pisa, Italy.

Stress echocardiography (SE) is based on the detection of regional wall motion abnormalities (RWMA) mirroring a physiologically critical epicardial artery stenosis determining subendocardial underperfusion. Recently the core protocol of SE was enriched by adding left ventricular contractile reserve (LVCR) based on Force. An altered Force can be due to microvascular and/or epicardial coronary artery disease, but also to myocardial scar, necrosis and/or sub-epicardial layer disease. Read More

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http://dx.doi.org/10.5603/KP.a2019.0002DOI Listing
January 2019

Association of and Coronary heart disease in Iran: A meta-analysis.

Med J Islam Repub Iran 2018 17;32:73. Epub 2018 Aug 17.

Cardiovascular Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Several studies in the recent decade have supported a relationship between different types of infections and CHD (Coronary Heart Disease); however, such a relationship is not definitely proven. Helicobacter pylori is one of the most common infections in human. The role of inflammation in the pathogens of CAD (Coronary Artery Disease) has been widely discussed; although, the mechanism is not clearly known yet. Read More

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http://dx.doi.org/10.14196/mjiri.32.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325280PMC

In-Hospital Outcomes of Rotational Atherectomy in High-Risk Patients With Severely Calcified Left Main Coronary Artery Disease: A Single-Center Experience.

J Invasive Cardiol 2019 Jan 15. Epub 2019 Jan 15.

Division of Cardiovascular Medicine, Keck School of Medicine, 1510 San Pablo Street, Suite 322, Los Angeles, CA 90033 USA.

Background: Severe coronary artery calcification is a challenge for percutaneous coronary intervention (PCI), particularly in left main coronary artery disease (LM-CAD). Rotational atherectomy (RA) is a useful tool for modification of calcified plaque prior to PCI. We report our experience with RA for severely calcified LM-CAD. Read More

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January 2019

Cystatin C for predicting all-cause mortality and rehospitalization in patients with heart failure: A meta-analysis.

Biosci Rep 2019 Jan 14. Epub 2019 Jan 14.

Health Service Centre of West Street Coummunity of Xiangshan District, Huaibei, China.

Circulating cystatin C has been identified as an independent predictor of all-cause mortality in patients with coronary artery disease and the general population. This meta-analysis aimed to systematically evaluate the association between elevated cystatin C level and all-cause mortality and rehospitalization risk among patients with heart failure (HF). PubMed and Embase databases were searched until December 2017. Read More

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http://dx.doi.org/10.1042/BSR20181761DOI Listing
January 2019

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.

Blood 2019 Jan 14. Epub 2019 Jan 14.

Department of Epidemiology, University of Washington, Seattle, WA, United States.

Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of nine genome-wide association studies of plasma FVII levels (seven FVII activity and two FVII antigen) among 27,495 participants of European and African ancestry. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-05
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http://dx.doi.org/10.1182/blood-2018-05-849240DOI Listing
January 2019
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A case of hypertrophic cardiomyopathy combined with muscular ventricular septal defect and abnormal origin of right coronary artery.

BMC Cardiovasc Disord 2019 Jan 14;19(1):16. Epub 2019 Jan 14.

Department of ultrasound, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China.

Background: Hypertrophic cardiomyopathy (HCM) is a myocardial disease. However, the coexistence of HCM with muscular ventricular septal defect (VSD), especially those with both incomplete spontaneous closure and coronary abnormal origin, is relatively rare.

Case Presentation: We report herein a unique case of HCM accompanied with incomplete spontaneous closure of muscular VSD and abnormal origin of right coronary artery (RCA) in a 26-year-old man, which was diagnosed by combination of transthoracic 2-dimensional (2D), color Doppler, Contrast-enhanced echocardiography and computed tomography angiography (CTA). Read More

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http://dx.doi.org/10.1186/s12872-018-0997-8DOI Listing
January 2019

Epicardial Fat Volume Improves the Prediction of Obstructive Coronary Artery Disease Above Traditional Risk Factors and Coronary Calcium Score.

Circ Cardiovasc Imaging 2019 Jan;12(1):e008002

Department of Cardiology (J.Z., Y.Z., Y.L., H.C.), Tianjin Chest Hospital, China.

Background: Recent studies have demonstrated the tremendous potential of epicardial fat volume (EFV) to predict obstructive coronary artery disease. We aimed to develop a new model to estimate pretest probability of obstructive coronary artery disease using traditional risk factors with coronary calcium score and EFV and compare it with proposed models in Chinese patients who underwent coronary computed tomography angiography.

Methods: The new models were derived from 5743 consecutive patients using multivariate logistic regression and validated in an internal cohort using invasive coronary angiography as the outcome and an external cohort with clinical outcome data. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008002DOI Listing
January 2019

Exercise training for patients with type 2 diabetes and cardiovascular disease: What to pursue and how to do it. A Position Paper of the European Association of Preventive Cardiology (EAPC).

Eur J Prev Cardiol 2019 Jan 14:2047487318820420. Epub 2019 Jan 14.

17 University Cardiology Department and Heart Failure Unit and Cardiopulmonary Laboratory, Cardiology, I.R.C.C.S., Milan, Italy.

Patients with type 2 diabetes mellitus suffer from dysregulation of a plethora of cardiovascular and metabolic functions, including dysglycaemia, dyslipidaemia, arterial hypertension, obesity and a reduced cardiorespiratory fitness. Exercise training has the potential to improve many of these functions, such as insulin sensitivity, lipid profile, vascular reactivity and cardiorespiratory fitness, particularly in type 2 diabetes mellitus patients with cardiovascular comorbidities, such as patients that suffered from an acute myocardial infarction, or after a coronary intervention such as percutaneous coronary intervention or coronary artery bypass grafting. The present position paper aims to provide recommendations for prescription of exercise training in patients with both type 2 diabetes mellitus and cardiovascular disease. Read More

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http://journals.sagepub.com/doi/10.1177/2047487318820420
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http://dx.doi.org/10.1177/2047487318820420DOI Listing
January 2019
1 Read

miRNA Polymorphisms and Risk of Cardio-Cerebrovascular Diseases: A Systematic Review and Meta-Analysis.

Int J Mol Sci 2019 Jan 12;20(2). Epub 2019 Jan 12.

Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz 5138663134, Iran.

Recently extensive focus has been concentrated on the role of miRNAs in the initiation and progression of cardio-cerebrovascular diseases (CCDs) which constitute a range of conditions including cardiovascular diseases (CVDs, especially coronary artery disease (CAD)), congenital heart disease (CHD) and cerebrovascular diseases (CBVDs, especially the ischemic stroke (IS)). An increasing number of studies are evaluating the association between different miRNA polymorphisms and risk of CCDs, but results have been inconclusive. This study represents a comprehensive systematic review and meta-analysis of the association between miRNA polymorphisms and risk of CCDs. Read More

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http://dx.doi.org/10.3390/ijms20020293DOI Listing
January 2019

Sex-Differences in the Pattern of Comorbidities, Functional Independence, and Mortality in Elderly Inpatients: Evidence from the RePoSI Register.

J Clin Med 2019 Jan 12;8(1). Epub 2019 Jan 12.

Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.

Background: The RePoSi study has provided data on comorbidities, polypharmacy, and sex dimorphism in hospitalised elderly patients.

Methods: We retrospectively analysed data collected from the 2010, 2012, 2014, and 2016 data sets of the RePoSi register. The aim of this study was to explore the sex-differences and to validate the multivariate model in the entire dataset with an expanded follow-up at 1 year. Read More

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http://dx.doi.org/10.3390/jcm8010081DOI Listing
January 2019

Rate of instrumentation changes on postoperative and follow-up radiographs after primary complex spinal fusion (five or more levels) for adult deformity correction.

J Neurosurg Spine 2019 Jan 11:1-6. Epub 2019 Jan 11.

2Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.

OBJECTIVEIn the United States, healthcare expenditures have been soaring at a concerning rate. There has been an excessive use of postoperative radiographs after spine surgery and this has been a target for hospitals to reduce unnecessary costs. However, there are only limited data identifying the rate of instrumentation changes on radiographs after complex spine surgery involving ≥ 5-level fusions. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18686DOI Listing
January 2019

The association between serum irisin levels and cardiovascular disease in diabetic patients.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):786-790. Epub 2018 Nov 30.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Cardiovascular disease is the most common cause of mortality and morbidity in diabetic patients. Insulin resistance has been shown to be reduced by the secretion of irisin from muscle and adipose tissues. This study was aimed at determining the relationship between serum irisin levels and angiographically defined coronary artery disease (CAD) in type II diabetic patients. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.050DOI Listing
November 2018

Lifestyle factors and macro- and micro-vascular complications among people with type 2 diabetes in Saudi Arabia.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):484-491. Epub 2018 Nov 3.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address:

Aims: The aim of this study is to identify lifestyle factors that place people with type 2 diabetes in Saudi Arabia at a greater risk of macro- and microvascular complications.

Methods: A survey was conducted among adults with type 2 diabetes who attended diabetes centres in three major cities in Saudi Arabia. Participants were interviewed and their medical files were reviewed for lab test results and documented comorbidities. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.007DOI Listing
November 2018

[Correlation Research on Blood Glucose Fluctuation in Type 2 Diabetes Mellitus Patients and Vas- cular Endothelial Injury/Platelet Activation/PKCβ1 Expression].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 10;36(10):1184-1190

Objective To observe the correlation between blood glucose fluctuation in type 2 dia- betes mellitus ( T2DM) patients and vascular endothelial injury/platelet activation/protein kinase Cβ1 (PKCpβ1). Methods Capillary blood was collected from finger tips of 38 T2DM patients at 7 time points, i.e. Read More

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October 2016
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