172,292 results match your criteria Coronary Artery Atherosclerosis


The emerging role of fentanyl in antiplatelet therapy.

J Cardiovasc Pharmacol 2020 Jun 30. Epub 2020 Jun 30.

Department of Haemostasis and Haemostatic Disorders, Chair of Biomedical Sciences, Medical University of Lodz, Lodz, Poland.

Fentanyl is a potent synthetic opioid used to alleviate severe and chronic pain, as well as an adjunct to general or local anesthesia. Although fentanyl has been used for decades, its full effects are still unknown. Its analgesic and anesthetic activity arises from stimulation of μ-opioid receptors, resulting in inhibition of adenyl cyclase and downregulation of cAMP, as well as decreased calcium channel activity and increased potassium channel activity. Read More

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http://dx.doi.org/10.1097/FJC.0000000000000880DOI Listing

Colon Involvement in Necrotizing Pancreatitis: Incidence, Risk Factors, and Outcomes.

Ann Surg 2020 Jul 7. Epub 2020 Jul 7.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.

Objective: To investigate the incidence, risk factors, and outcomes of colon involvement in patients with necrotizing pancreatitis.

Summary/background Data: Necrotizing pancreatitis is characterized by a profound inflammatory response with local and systemic implications. Mesocolic involvement can compromise colonic blood supply leading to ischemic complications; however, few data exist regarding this problem. Read More

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http://dx.doi.org/10.1097/SLA.0000000000004149DOI Listing

Stress cardiac MRI in stable coronary artery disease.

Curr Opin Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Division of Cardiology, Department of Medicine.

Purpose Of Review: Noninvasive testing is often the first step in the evaluation of stable coronary artery disease (CAD). Stress cardiac MRI (CMR) is an established modality with high diagnostic accuracy and prognostic value. This review will focus on the recent advances in understanding how stress CMR can help guide patient care. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000776DOI Listing

Percutaneous management of coronary bifurcation lesions: current perspective.

Curr Opin Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Division of Cardiology, Southlake Regional Health Centre, Newmarket, Ontario, Canada.

Purpose Of Review: Coronary artery disease affecting bifurcations poses a challenge for percutaneous intervention. Several techniques and strategies for percutaneous management of bifurcation lesions have been described in the literature with variable data available for outcomes. In this review, we provide an overview of the strategies and techniques used for percutaneous intervention of bifurcation lesions with an update of recent technical developments and clinical evidence. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000775DOI Listing

The evolving role of coronary artery calcium in preventive cardiology 30 years after the Agatston score.

Curr Opin Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Division of Cardiology, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Purpose Of Review: On the brink of the 30th anniversary of the Agatston score we summarize the epidemiological data that shaped the recommendations relevant to coronary artery calcium (CAC) included in the 2018/2019 US and European guidelines for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). We also discuss the implications of novel CAC research conducted in asymptomatic populations within the past 2 years.

Recent Findings: Based on a wealth of observational evidence, CAC has emerged as a mainstay in personalized risk assessment and is now endorsed as a class IIa tool in both US and European guidelines. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000771DOI Listing

Assessment and management of coronary artery disease in patients undergoing transcatheter aortic valve replacement.

Curr Opin Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Division of Cardiology, Southlake Regional Health Centre, Newmarket.

Purpose Of Review: Coronary artery disease (CAD) is commonly observed in patients undergoing transcatheter aortic valve replacement (TAVR). Significant variability exists across institutions for strategies used for CAD diagnosis and its management. The heart team often relies upon traditional practice patterns and the decision for revascularization by percutaneous coronary intervention (PCI) is influenced by patient, angiographic, operator, and system-related factors. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000768DOI Listing

The COMPASS trial: practical considerations for application after coronary artery bypass surgery.

Curr Opin Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, Max Rady College of Medicine, University of Manitoba.

Purpose Of Review: We review the cardiovascular outcomes for people using anticoagulation strategies (COMPASS) trial with particular emphasis on patients with a history of remote coronary artery bypass grafting (CABG) and those who were enrolled 4-14 days after CABG. We provide practical guidance for selecting patients with the greatest potential to benefit who have acceptable bleeding risk. In particular, we address concerns about postoperative bleeding and discuss the relative merits of rivaroxaban and aspirin versus P2Y12 inhibition and aspirin. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000766DOI Listing

A comparison of surgical, total percutaneous, and hybrid approaches to treatment of combined coronary artery and valvular heart disease.

Curr Opin Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, Division of Cardiac Surgery, University of Alberta, Edmonton, Alberta, Canada.

Purpose Of Review: The purpose of this review is to compare outcomes of surgical valve replacement (SVR) and coronary artery bypass grafting (CABG), minimally invasive cardiac surgery (MICS) SVR and percutaneous coronary intervention (PCI), and transcatheter aortic valve replacement and PCI for the treatment of combined coronary artery disease (CAD) and valvular heart disease (VHD).

Recent Findings: Several studies have attempted to identify key differences in outcomes with hybrid MICS SVR and PCI approaches to combined CAD and VHD. Recent studies have demonstrated that MICS SVR and PCI, when compared with conventional open SVR and CABG, demonstrate reduced or unchanged morbidity and mortality. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000764DOI Listing

Association between marijuana use and electrocardiographic abnormalities by middle age The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Addiction 2020 Jul 10. Epub 2020 Jul 10.

Institute of Primary Health Care (BIHAM), University of Bern, Switzerland.

Aims: To evaluate the prevalence of electrocardiogram (ECG) abnormalities in marijuana users as an indirect measure of subclinical cardiovascular disease (CVD).

Design: Longitudinal and cross-sectional secondary data analysis from the CARDIA (Coronary Artery Risk Development in Young Adults) study.

Setting: 4 communities in the United States. Read More

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http://dx.doi.org/10.1111/add.15188DOI Listing

Patients with moderate chronic kidney disease without heart disease have reduced coronary flow velocity reserve.

ESC Heart Fail 2020 Jul 10. Epub 2020 Jul 10.

Department of Molecular and Clinical Medicine/Nephrology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Aims: The overall aim was to identify sub-clinical cardiac abnormalities by echocardiography in patients with chronic kidney disease (CKD) stages 3 and 4 and to investigate underlying mechanisms.

Methods And Results: Ninety-one patients with CKD stages 3 and 4, without a diagnosis of heart disease, and 41 healthy matched controls were included in this cross-sectional study. Cardiac morphology and function were analysed with Doppler echocardiography and coronary flow velocity reserve (CFVR) in response to adenosine was measured in the left anterior descendent artery to detect coronary microvascular dysfunction (CMD). Read More

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http://dx.doi.org/10.1002/ehf2.12878DOI Listing

Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross-sectional study.

J Periodontal Res 2020 Jul 9. Epub 2020 Jul 9.

Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.

Objective: The objective of the study is to examine the connection between oral status and the extent of coronary artery disease (CAD), which is diagnosed by angiography.

Background: Periodontitis and tooth loss have been linked to atherosclerosis and CAD in previous studies. However, no distinct connection was revealed due to the diversity of the results and the variety of diagnostic methods. Read More

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http://dx.doi.org/10.1111/jre.12782DOI Listing

Immunomodulation of the NLRP3 Inflammasome in Atherosclerosis, Coronary Artery Disease, and Acute Myocardial Infarction.

J Cardiovasc Transl Res 2020 Jul 9. Epub 2020 Jul 9.

Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.

Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity worldwide. Atherosclerosis is responsible for the majority of cardiovascular disorders with inflammation as one of its driving processes. The nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, responsible for the release of the pro-inflammatory cytokines, interleukin-1β (IL-1β), and interleukin-18 (IL-18), has been studied extensively and showed to play a pivotal role in the progression of atherosclerosis, coronary artery disease (CAD), and myocardial ischemia reperfusion (I/R) injury. Read More

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http://dx.doi.org/10.1007/s12265-020-10049-wDOI Listing

Late lumen enlargement after drug-coated balloon angioplasty for de novo coronary artery disease.

Cardiovasc Interv Ther 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiology, Hiratsuka Kyosai Hospital, 9-11 Oiwake, Hiratsuka, Kanagawa, Japan.

We aimed to identify predictors of late lumen enlargement (LLE) after drug-coated balloon (DCB) angioplasty for de novo coronary lesions. LLE, which is defined as an increase in the luminal diameter of the vessel from the immediate postprocedural measurement to follow-up measurements, is frequently observed after DCB angioplasty for de novo coronary artery disease. No predictors of LLE are known. Read More

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http://dx.doi.org/10.1007/s12928-020-00690-2DOI Listing

Machine Learning and Coronary Artery Calcium Scoring.

Curr Cardiol Rep 2020 Jul 9;22(9):90. Epub 2020 Jul 9.

Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC, 29425, USA.

Purpose Of Review: To summarize current artificial intelligence (AI)-based applications for coronary artery calcium scoring (CACS) and their potential clinical impact.

Recent Findings: Recent evolution of AI-based technologies in medical imaging has accelerated progress in CACS performed in diverse types of CT examinations, providing promising results for future clinical application in this field. CACS plays a key role in risk stratification of coronary artery disease (CAD) and patient management. Read More

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http://dx.doi.org/10.1007/s11886-020-01337-7DOI Listing

Antibody microarray analysis of serum inflammatory cytokines in patients with calcific aortic valve disease.

Ann Transl Med 2020 Jun;8(12):761

Department of Cardiovascular Surgery, Tianjin Chest Hospital, Tianjin, China.

Background: Calcific aortic valve disease (CAVD) is a slowly progressive pathologic process associated with significant morbidity and mortality, CAVD is the most common valve heart disease in the elderly and a leading cause of aortic valve stenosis. Multiple steps characterize the process: inflammation, cell apoptosis, lipid deposition, renin-angiotensin system activation, extracellular matrix remodeling, and bone formation. This paper focuses on detecting and analyzing the expression of serum inflammatory factors in CAVD by antibody microarray techniques. Read More

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http://dx.doi.org/10.21037/atm-20-4463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333163PMC

CircRNA ZNF609 in peripheral blood leukocytes acts as a protective factor and a potential biomarker for coronary artery disease.

Ann Transl Med 2020 Jun;8(12):741

Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Circular RNAs (circRNAs) have been reported to aberrantly express in coronary artery disease (CAD). Due to their special structures, circRNAs have the potential to be specific and stable markers. We conducted this study to explore circZNF609's function in atherosclerosis and to evaluate its predictive values for CAD. Read More

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http://dx.doi.org/10.21037/atm-19-4728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333115PMC

Aspirin use for cardiovascular disease prevention in the uninsured population.

SAGE Open Med 2020 30;8:2050312120938224. Epub 2020 Jun 30.

Department of Internal Medicine, University of South Florida, Tampa, FL, USA.

Introduction: Aspirin is an effective anti-inflammatory and antiplatelet agent as an irreversible inhibitor of cyclooxygenase. In 2016, the U.S. Read More

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http://dx.doi.org/10.1177/2050312120938224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328214PMC

HOPE for Rational Statin Allocation for Primary Prevention: A Coronary Artery Calcium Picture Is Worth 1000 Words.

Mayo Clin Proc 2020 Jul 2. Epub 2020 Jul 2.

Department of Applied Health Science, School of Public Health, Indiana University Bloomington, IN.

Allocation of statin therapy for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) in borderline- and intermediate-risk patients has traditionally been based on population-based global risk assessment and other clinical and laboratory characteristics. Patient-specific treatment decisions are needed to provide maximal benefit and avoid unnecessary treatment. Guideline-based lipid management proposes that coronary artery calcium scoring is reasonable to implement in patients with a 10-year risk of 5. Read More

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http://dx.doi.org/10.1016/j.mayocp.2020.01.016DOI Listing

Multivessel Versus Culprit-Only Revascularization in STEMI and Multivessel Coronary Artery Disease: Meta-Analysis of Randomized Trials.

JACC Cardiovasc Interv 2020 Jul;13(13):1571-1582

Division of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address:

Objectives: The goal of this systematic review and meta-analysis was to provide a comprehensive evaluation of contemporary randomized trials addressing the efficacy and safety of multivessel versus culprit vessel-only percutaneous coronary intervention (PCI) among patients presenting with ST-segment elevation myocardial infarction and multivessel coronary artery disease.

Background: Multivessel coronary artery disease is present in about one-half of patients with ST-segment elevation myocardial infarction. Randomized controlled trials comparing multivessel and culprit vessel-only PCI produced conflicting results regarding the benefits of a multivessel PCI strategy. Read More

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http://dx.doi.org/10.1016/j.jcin.2020.04.055DOI Listing

Acute Coronary Syndromes and Multivessel Disease: Completing the Evidence.

JACC Cardiovasc Interv 2020 Jul;13(13):1568-1570

Cardiology Division, Heart Center, Luzerner Kantonsspital, Lucerne, Switzerland.

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http://dx.doi.org/10.1016/j.jcin.2020.05.041DOI Listing

Post-Discharge Bleeding and Mortality Following Acute Coronary Syndromes With or Without PCI.

J Am Coll Cardiol 2020 Jul;76(2):162-171

Duke Clinical Research Institute, Durham, North Carolina; Division of Cardiology, Duke University School of Medicine, Durham, North Carolina. Electronic address:

Background: The long-term prognostic impact of post-discharge bleeding in the unique population of patients with acute coronary syndrome (ACS) treated without percutaneous coronary intervention (PCI) remains unexplored.

Objectives: The aim of this study was to assess the association between post-discharge bleeding and subsequent mortality after ACS according to index strategy (PCI or no PCI) and to contrast with the association between post-discharge myocardial infarction (MI) and subsequent mortality.

Methods: In a harmonized dataset of 4 multicenter randomized trials (APPRAISE-2 [Apixaban for Prevention of Acute Ischemic Events-2], PLATO [Study of Platelet Inhibition and Patient Outcomes], TRACER [Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome], and TRILOGY ACS [Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes]), the association between post-discharge noncoronary artery bypass graft-related GUSTO (Global Use of Strategies to Open Occluded Coronary Arteries) moderate, severe, or life-threatening bleeding (landmark 7 days post-ACS) and subsequent all-cause mortality was evaluated in a time-updated Cox proportional hazards analysis. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.05.031DOI Listing

10-Year Outcomes From a Randomized Trial of Polymer-Free Versus Durable Polymer Drug-Eluting Coronary Stents.

J Am Coll Cardiol 2020 Jul;76(2):146-158

Dublin Cardiovascular Research Institute, Mater Private Hospital, Dublin, Ireland; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

Background: Outcome data after extended long-term follow-up of patients with coronary artery disease treated with drug-eluting stents (DES) in randomized clinical trials are scant.

Objectives: Performance differences among devices may be expected to emerge over time depending on whether stenting is done with polymer-free or durable polymer DES. This study assessed the 10-year outcomes of patients enrolled in the ISAR-TEST-5 (Test Efficacy of Sirolimus- and Probucol-Eluting Versus Zotarolimus-Eluting Stents) trial. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.05.026DOI Listing

Lipoprotein (a) predicts recurrent worse outcomes in type 2 diabetes mellitus patients with prior cardiovascular events: a prospective, observational cohort study.

Cardiovasc Diabetol 2020 Jul 9;19(1):111. Epub 2020 Jul 9.

State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China.

Background: Merging studies have reported the association of lipoprotein(a) [Lp(a)] with poor outcomes of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). However, the prognostic importance of Lp(a) for recurrent cardiovascular events (CVEs) is currently undetermined in patients with T2DM and prior CVEs.

Methods: From April 2011 to March 2017, we consecutively recruited 2284 T2DM patients with prior CVEs. Read More

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http://dx.doi.org/10.1186/s12933-020-01083-8DOI Listing

Nonculprit Lesion Plaque Morphology in Patients With ST-Segment-Elevation Myocardial Infarction: Results From the COMPLETE Trial Optical Coherence Tomography Substudys.

Circ Cardiovasc Interv 2020 Jul 10;13(7):e008768. Epub 2020 Jul 10.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, ON, Canada (N.P.-E., S.R.M., J.W., H.N., B.M., T.S.).

Background: Complete revascularization with routine percutaneous coronary intervention of nonculprit lesions after primary percutaneous coronary intervention improves outcomes in ST-segment-elevation myocardial infarction. Whether this benefit is associated with nonculprit lesion vulnerability is unknown.

Methods: In a prospective substudy of the COMPLETEs trial (Complete vs Culprit-Only Revascularization to Treat Multi-Vessel Disease After Early PCI for STEMI), we performed optical coherence tomography of at least 2 coronary arteries before nonculprit lesion percutaneous coronary intervention in 93 patients with ST-segment-elevation myocardial infarction and multivessel disease; and the ST-segment-elevation myocardial infarction culprit vessel if there was unstented segment amenable to imaging. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008768DOI Listing

Insulin Resistance Predicts Severity of Coronary Atherosclerotic Disease in Non-Diabetic Patients.

J Clin Med 2020 Jul 7;9(7). Epub 2020 Jul 7.

Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.

Background: Insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) represents a predictor of coronary artery disease (CAD). However, how IR is able to impact the severity of coronary atherosclerosis in non-diabetic patients is unknown.

Objectives: We investigated the relation between the IR and the extent and severity of coronary atherosclerosis in non-diabetic patients referred to coronary angiography (CA) Methods: Consecutive patients undergoing to CA for acute coronary syndromes or stable angina were analyzed. Read More

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http://dx.doi.org/10.3390/jcm9072144DOI Listing

Management of 760-g Extremely Premature Infant With Dextro-Transposition of the Great Arteries.

World J Pediatr Congenit Heart Surg 2020 Jul;11(4):518-519

Congenital Heart Center, Spectrum Health Helen DeVos Children's Hospital, Grand Rapids, MI, USA.

Extremely low birth weight neonates with complex congenital heart disease have increased mortality risk. Multi-organ dysfunction, pulmonary disease, fluctuating pulmonary vascular resistance, and complex cardiovascular anatomy create a challenge for effective management. We present the case of a 760-g neonate with dextro-transposition of the great arteries, ventricular septal defect, patent ductus arteriosus, and single coronary artery with proximal intramural segment of the right coronary artery branch. Read More

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http://dx.doi.org/10.1177/2150135120908777DOI Listing

Cost-utility of ticagrelor plus aspirin in diabetic patients with stable coronary artery disease.

Authors:
Bin Wu Lizheng Shi

Eur Heart J Cardiovasc Pharmacother 2020 Jul 9. Epub 2020 Jul 9.

Department of Health Policy and Management, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.

Aims: Ticagrelor plus aspirin could reduce the risks of major adverse cardiac events in diabetic patients with stable coronary artery disease (SCD), and yet it also increases bleeding risk. This study would compare the cost and effectiveness of aspirin and ticagrelor plus aspirin therapies in diabetic patients with SCD from a US health care sector perspective.

Methods And Results: A state-transition Markov model was developed to project probabilities of MI, IS, bleeding and death with and without ticagrelor among all diabetic patients with SCD as the overall population, and those with a history of previous percutaneous coronary intervention (PCI) as a sub-population. Read More

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http://dx.doi.org/10.1093/ehjcvp/pvaa082DOI Listing

Control of blood pressure levels in patients with premature coronary artery disease: Results from the Genetics of Atherosclerotic Disease study.

J Clin Hypertens (Greenwich) 2020 Jul 9. Epub 2020 Jul 9.

Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

High blood pressure (BP) is the major cardiovascular-risk factor for coronary artery disease (CAD), principally in young patients who have an important and increasing socioeconomic burden. Despite the Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7), recommended BP target <140/90 mm Hg for patients with stable CAD, in 2017 the American College of Cardiology and the American Heart Association (ACC/AHA) updated BP target to <130/80 mm Hg. We aimed to analyze the prevalence of BP control in patients with premature CAD using both criteria. Read More

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http://dx.doi.org/10.1111/jch.13942DOI Listing

Can the expression of the metalloproteinase 9 gene and its inhibitor be considered as markers of heart failure?

Minerva Cardioangiol 2020 Jul 8. Epub 2020 Jul 8.

Department of Cardiology, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.

Background: Heart failure (HF) is a major cause of mortality in developed countries. Its formation is associated with a change in the transcriptional activity of many genes. The aim of the study was to select, from the group of genes related to coronary atherosclerosis and heart failure, genes differentiating patients with coronary heart disease and heart failure on the basis of myocardial ischemia from healthy people, and then genes differentiating patients with various stages of heart failure. Read More

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http://dx.doi.org/10.23736/S0026-4725.20.05202-0DOI Listing

Dementia screening in elderly high-risk patients following heart failure decompensation may predict unfavorable long-term clinical outcomes.

Minerva Cardioangiol 2020 Jul 8. Epub 2020 Jul 8.

Department of Coronary Artery Disease and Heart Failure, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.

Background: Recently heart failure (HF) has been found to be a new dementia risk factor, nevertheless their relations in patients following HF decompensation remain unknown. We sought to investigate whether a screening diagnosis for dementia (SDD) in this high-risk population may predict unfavorable long-term clinical outcomes.

Methods: 142 patients following HF decompensation requiring hospitalization were enrolled. Read More

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http://dx.doi.org/10.23736/S0026-4725.20.05157-9DOI Listing

Pericardial adiposity versus body adiposity measured by BMI in the assessment of coronary atherosclerosis burden in patients with hypertension.

Clin Exp Hypertens 2020 Jul 8:1-5. Epub 2020 Jul 8.

Radiology Department, Medicine College, University of Kufa , Najaf, Iraq.

Objectives: The link between obesity and hypertension with coronary atherosclerosis is complex. We aimed to assess the association of cardiac fat deposition measured by pericardial fat volume(PFV) using by multi-detector CT(MDCT) and general obesity measured by BMI with subclinical coronary atherosclerotic markers (coronary artery calcium score (CAC), coronary plaque and stenosis) in patients with hypertension and suspected coronary artery disease.

Methods: Among 496 patients presenting with chest pain who underwent 64-slice MDCT angiography to exclude occlusive coronary disease, 261 patients with hypertension (age: 57 ± 8 years, 45% males) enrolled in the present study. Read More

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http://dx.doi.org/10.1080/10641963.2020.1790587DOI Listing

Prognostic Factors and Outcomes in Young Patients With Presented of Different Types Acute Coronary Syndrome.

Angiology 2020 Jul 9:3319720939444. Epub 2020 Jul 9.

Department of Cardiology, Sakarya University Education and Research Hospital, Sakarya, Turkey.

The prevalence of coronary artery disease is increasing in young adults. We evaluated the outcomes of different types of acute coronary syndrome in 917 patients undergoing coronary angiography aged ≤45 years. Male sex, smoking, dyslipidemia were the most important risk factors. Read More

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http://dx.doi.org/10.1177/0003319720939444DOI Listing

Increased incidence of serious late adverse events with drug-eluting stents when compared with coronary artery bypass surgery: a cause of concern.

Future Cardiol 2020 Jul 9. Epub 2020 Jul 9.

Cardiac Unit Otamendi Hospital Cardiovascular Research Center (CECI) Azcuenaga 870, Buenos Aires, Argentina.

Percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) in pre-drug-eluting stents (DESs) era, randomized trials and meta-analysis showed that the extension of coronary artery disease was not associated with a better survival with CABG, and only diabetic patients had an inferior survival with PCI. After the introduction of DES, we would expect a substantial improvement in PCI results compared with CABG, narrowing the gap between both revascularization strategies, However, on the contrary, most randomized studies between DES and CABG showed that rate of recurrences remained and there is an unexpected increased of late serious adverse events including spontaneous myocardial infarction and death. In this review, we try to described each of these problems and find out explanations for these new findings searching for potential solutions. Read More

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http://dx.doi.org/10.2217/fca-2020-0033DOI Listing

Empirical use of causal inference methods to evaluate survival differences in a real-world registry vs those found in randomized clinical trials.

Stat Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.

With heighted interest in causal inference based on real-world evidence, this empirical study sought to understand differences between the results of observational analyses and long-term randomized clinical trials. We hypothesized that patients deemed "eligible" for clinical trials would follow a different survival trajectory from those deemed "ineligible" and that this factor could partially explain results. In a large observational registry dataset, we estimated separate survival trajectories for hypothetically trial-eligible vs ineligible patients under both coronary artery bypass surgery (CABG) and percutaneous coronary intervention (PCI). Read More

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http://dx.doi.org/10.1002/sim.8581DOI Listing

Temporal patterns and short-term progression of paroxysmal atrial fibrillation: data from RACE V.

Europace 2020 Jul 8. Epub 2020 Jul 8.

Department of Cardiology, University Medical Centre Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

Aims: Atrial fibrillation (AF) often starts as a paroxysmal self-terminating arrhythmia. Limited information is available on AF patterns and episode duration of paroxysmal AF. In paroxysmal AF patients, we longitudinally studied the temporal AF patterns, the association with clinical characteristics, and prevalence of AF progression. Read More

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http://dx.doi.org/10.1093/europace/euaa123DOI Listing

MINOCA: The caveat of absence of coronary obstruction in myocardial infarction.

Int J Cardiol Heart Vasc 2020 Aug 1;29:100572. Epub 2020 Jul 1.

Department of Cardiology, Maastricht University Medical Centre, Maastricht, the Netherlands.

Aims: Whether patients with MINOCA (myocardial infarction with non-obstructive coronary arteries) have better outcomes than patients with obstructive coronary artery disease remains contradictory. The current study focussed on the clinical profile and prognosis of MINOCA patients.

Methods And Results: We performed a retrospective analysis of patients with acute coronary syndrome (ACS) admitted to the Isala hospital in Zwolle, the Netherlands, between 2006 and 2014. Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334364PMC

A study on the prevalence, distribution and related factors of heart valve calcification using coronary CT angiography.

Int J Cardiol Heart Vasc 2020 Aug 1;29:100571. Epub 2020 Jul 1.

Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Background: The concept of active atherosclerotic disease has been accepted for heart valve calcification (HVC). We investigated prevalence, distribution and related factors of HVC in patients who had undergone coronary CT angiography (CCTA).

Methods: Subjects were consecutive 200 patients who underwent CCTA. Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334460PMC

The effectiveness of mindfulness-based intervention on perceived stress and perception of disease in patients with acute coronary syndrome.

J Educ Health Promot 2020 28;9:130. Epub 2020 May 28.

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Context: One of the most important issues in patients with coronary artery disease is their mental health indices such as perceived stress and perception of disease.

Aims: The aim of this study was to evaluate the effectiveness of mindfulness-based intervention on the perceived stress and disease perception of patients with acute coronary syndrome.

Materials And Methods: This is a clinical trial, two-group, and three-stage study on 76 patients with acute coronary syndrome who were randomly divided into intervention and control groups. Read More

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http://dx.doi.org/10.4103/jehp.jehp_660_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325788PMC

Free Wall Myocardial Rupture and Ventricular Septal Defect in an Ambulatory Patient.

Cureus 2020 Jun 6;12(6):e8470. Epub 2020 Jun 6.

Cardiology, Carle Foundation Hospital, Urbana, USA.

Myocardial rupture is a rare complication of acute myocardial infarction (MI), usually presenting with chest pain. The most common site of rupture is the anterior wall. Myocardial rupture presents similar to cardiac tamponade, most frequently as cardiogenic shock. Read More

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http://dx.doi.org/10.7759/cureus.8470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336576PMC

Partial Annuloplasty Rings in the Repair of Functional Ischemic Mitral Regurgitation.

Cureus 2020 Jun 3;12(6):e8419. Epub 2020 Jun 3.

Research and Statistics, Tabba Institute of Heart Disease, Karachi, PAK.

Background Acute myocardial infarction (MI) is the leading cause of worldwide cardiac morbidities and mortalities. Mitral regurgitation (MR) is a common complication of MI. The severity of ischemic MR (IMR) can range widely, both clinically and hemodynamically. Read More

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http://dx.doi.org/10.7759/cureus.8419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336716PMC

3D printing in adult cardiovascular surgery and interventions: a systematic review.

J Thorac Dis 2020 Jun;12(6):3227-3237

Department of Cardiovascular Surgery, Jinling Hospital, Nanjing University, School Medicine, Nanjing 210002, China.

3D printing in adult cardiac and vascular surgery has been evaluated over the last 10 years, and all of the available literature reports benefits from the use of 3D models. In the present study, we analyzed the current applications of 3D printing for adult cardiovascular disease treated with surgical or catheter-based interventions, including the clinical medical simulation of physiological or pathology conducted with 3D printing in this field. A search of PubMed and MEDLINE databases were supplemented by searching through bibliographies of key articles. Read More

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http://dx.doi.org/10.21037/jtd-20-455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330795PMC

Structural heart disease: the year in valvular and complex coronary intervention trials.

J Thorac Dis 2020 May;12(5):2910-2918

Echocardiography Laboratory, Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL, USA.

The need for treatment strategies targeting complex structural heart and obstructive epicardial coronary artery disease (CAD) is rapidly growing. The demographics in referral centers has shifted to an older population with greater co-morbidities and higher risk. Indeed, nearly one quarter of patients in tertiary-care settings have moderate or severe valvular heart disease, and despite a decrease in overall CAD burden in the United States over the past two decades the prevalence of myocardial infarction remains high. Read More

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http://dx.doi.org/10.21037/jtd.2019.12.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330406PMC

The impact of beta-blocker use on postoperative atrial fibrillation after aortic valve replacement.

J Thorac Dis 2020 May;12(5):2545-2552

Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background: Current guidelines recommend perioperative use of beta-blocker (BB) in patients undergoing cardiac surgery to prevent postoperative atrial fibrillation (POAF). However, this recommendation is mainly based on studies those exclusively enrolled patients undergoing coronary artery bypass grafting. This study was conducted to evaluate the impact of perioperative BB use on the occurrence of POAF after aortic valve replacement (AVR). Read More

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http://dx.doi.org/10.21037/jtd.2020.03.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330287PMC

Predictors of survival following veno-arterial extracorporeal membrane oxygenation in patients with acute myocardial infarction-related refractory cardiogenic shock: clinical and coronary angiographic factors.

J Thorac Dis 2020 May;12(5):2507-2516

Division of Cardiology, Department of Internal Medicine, Hallym University Medical Center, Anyang, Gyeonggi, Korea.

Background: This study aimed to identify the determinant factors of survival in patients with acute myocardial infarction (AMI) and refractory cardiogenic shock (RCS) who underwent veno-arterial extracorporeal membrane oxygenation (ECMO).

Methods: Sixty-nine consecutive patients with AMI-related RCS were enrolled in the study. They were treated with ECMO and primary percutaneous coronary intervention (PCI). Read More

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http://dx.doi.org/10.21037/jtd.2020.03.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330300PMC

A study on the risk factors of coronary artery disease in patients with Takayasu arteritis.

J Thorac Dis 2020 May;12(5):2031-2038

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: The aim of this study was to investigate the risk factors of Takayasu arteritis (TA) involving the coronary artery.

Methods: Patients with TA involving coronary artery were included in this study. According to the patients' condition of coronary artery involvement, they were divided into two groups: group A: TA involved coronary artery disease [at least one coronary artery stenosis (≥50%)] and group B: TA did not involve coronary artery. Read More

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http://dx.doi.org/10.21037/jtd-20-267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330393PMC

The effect of endoscopic vein harvesting in coronary artery bypass surgery.

J Thorac Dis 2020 May;12(5):1991-1998

Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Background: To compare the clinical outcomes, quality of saphenous vein (SV) grafts, and wound complications between endoscopic vein harvesting (EVH) technique and open vein harvesting (OVH) technique in patients with coronary artery bypass graft (CABG) surgery.

Methods: We reviewed one hundred patients with multi-vessel coronary artery disease who underwent elective CABG and agreed to preserve their SV specimens for study. Fifty patients (OVH group) underwent OVH, and the remaining (EVH group) underwent EVH. Read More

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http://dx.doi.org/10.21037/jtd-20-250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330341PMC