161,571 results match your criteria Coronary Artery Atherosclerosis


Increased bodyweight and inadequate response to aspirin in individuals with coronary artery disease.

J Thromb Thrombolysis 2019 Mar 16. Epub 2019 Mar 16.

Instituto do Coracao (InCor), Unidade de Coronariopatia Aguda, Hospital das Clinicas, Faculdade de Medicina (HCFMUSP), Universidade de Sao Paulo, São Paulo, Brazil.

Recent reports have suggested that aspirin effect might be influenced by bodyweight, with decreased efficacy in heavier individuals. We investigated the influence of bodyweight on aspirin pharmacodynamics in two independent datasets of patients taking non-enteric coated aspirin 100 mg QD for coronary artery disease (CAD). In the first dataset, 368 patients had their platelet aggregation assessed using VerifyNow Aspirin and measured in Aspirin Reaction Units (ARU). Read More

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http://dx.doi.org/10.1007/s11239-019-01830-zDOI Listing

First report of a hybrid robotic beating-heart quadruple totally endoscopic coronary artery bypass: toward complete revascularization.

Eur J Cardiothorac Surg 2019 Mar 16. Epub 2019 Mar 16.

Department of Surgery, Section of Cardiac and Thoracic Surgery, University of Chicago, Chicago, IL, USA.

To the best of our knowledge, this is the first report describing robotic beating-heart quadruple all-arterial totally endoscopic coronary artery bypass combined with percutaneous coronary intervention attempting complete revascularization (residual SYNTAX score 0). A 66-year-old male with severe triple-vessel coronary artery disease underwent percutaneous coronary intervention for a sub-total occlusion of the right coronary artery as the initial component of a hybrid revascularization strategy. Subsequently, the left coronary system was revascularized via robotic beating-heart totally endoscopic coronary artery bypass with bilateral internal mammary artery grafts. Read More

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http://dx.doi.org/10.1093/ejcts/ezz076DOI Listing

Pros and cons of antithrombotic therapy in end-stage kidney disease: a 2019 update.

Nephrol Dial Transplant 2019 Mar 16. Epub 2019 Mar 16.

the Academy of Romanian Scientists (AOSR).

Dialysis patients manifest both an increased thrombotic risk and a haemorrhagic tendency. A great number of patients with chronic kidney disease requiring dialysis have cardiovascular comorbidities (coronary artery disease, atrial fibrillation or venous thromboembolism) and different indications for treatment with antithrombotics (primary or secondary prevention). Unfortunately, few randomized controlled trials deal with antiplatelet and/or anticoagulant therapy in dialysis. Read More

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http://dx.doi.org/10.1093/ndt/gfz040DOI Listing

Total occlusion of the left main coronary artery presenting as ST-elevation myocardial infarction.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1136/bcr-2018-228658DOI Listing

Impact of Intravascular Ultrasound-Guided Percutaneous Coronary Intervention on Long-Term Clinical Outcomes in Patients Undergoing Complex Procedures.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: This study sought to determine whether intravascular ultrasound (IVUS) guidance compared with angiographic guidance reduces long-term risk of cardiac death in patients undergoing complex percutaneous coronary intervention (PCI).

Background: Although IVUS is a useful tool for accurate assessment of lesion profiles and optimal stent implantation, there are limited data on long-term clinical outcomes between IVUS-guided and angiography-guided PCI for patients with complex lesions.

Methods: From March 2003 through December 2015, a total of 6,005 patients undergoing PCI for complex lesions with drug-eluting stents were enrolled from a prospective institutional registry. Read More

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http://dx.doi.org/10.1016/j.jcin.2019.01.227DOI Listing

Imaging Risk in Multisystem Inflammatory Diseases.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Second Cardiology Department, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Greece.

Rheumatic diseases are immune-mediated inflammatory multisystem diseases with frequent cardiovascular manifestations including perimyocarditis, valvular disease, coronary artery disease, heart failure with or without preserved ejection fraction, pulmonary hypertension, aneurysms, and thrombosis. Echocardiography, carotid ultrasonography, cardiac computed tomography, cardiac magnetic resonance imaging, and positron emission tomography are valid diagnostic tools for the detection of the cardiovascular complications of the multisystem diseases that frequently determine prognosis. Furthermore, the findings of these methods may offer additive risk stratification in asymptomatic patients over the conventional risk scores used to assess cardiovascular risk in the primary prevention setting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X193017
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http://dx.doi.org/10.1016/j.jcmg.2018.06.033DOI Listing
March 2019
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The Association of Coronary Artery Calcification With Subsequent Incidence of Cardiovascular Disease in Type 1 Diabetes: The DCCT/EDIC Trials.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Department of Biostatistics, George Washington University, Rockville, Maryland.

Objectives: This study sought to determine the relationship between coronary artery calcium (CAC) scores and subsequent cardiovascular disease (CVD) events in DCCT (Diabetes Control and Complications Trial)/EDIC (Epidemiology of Diabetes Interventions and Complications) participants.

Background: The CAC score has been validated for improved risk stratification in general populations; however, this association has not been well studied in type 1 diabetes (T1DM).

Methods: Computed tomography (CT) to measure CAC was performed in 1,205 DCCT/EDIC participants at a mean of 42. Read More

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http://dx.doi.org/10.1016/j.jcmg.2019.01.014DOI Listing

Coronary Calcium in Type 1 Diabetes: To Screen or Not to Screen?

Authors:
Nathan D Wong

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Division of Cardiology, Heart Disease Prevention Program, University of California, Irvine, Irvine, California. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2019.01.016DOI Listing

Network meta-analysis of randomised trials of pharmacological, psychotherapeutic, exercise and collaborative care interventions for depressive symptoms in patients with coronary artery disease: hybrid systematic review of systematic reviews protocol.

Syst Rev 2019 Mar 16;8(1):71. Epub 2019 Mar 16.

Queen's University Belfast, Belfast, UK.

Background: Depression is common in patients with coronary artery disease (CAD) and is associated with poorer outcomes and higher costs. Several randomised controlled trials (RCTs) targeting depression, of various modalities (including pharmacological, psychotherapeutic and other approaches), have been conducted and summarised in pairwise meta-analytic reviews. However, no study has considered the cumulative evidence within a network, which can provide valuable indirect comparisons and information about the relative efficacy of interventions. Read More

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http://dx.doi.org/10.1186/s13643-019-0985-9DOI Listing

One-year clinical outcomes between biodegradable-polymer-coated biolimus-eluting stent and durable-polymer-coated drug-eluting stents in STEMI patients with multivessel coronary artery disease undergoing culprit-only or multivessel PCI.

Atherosclerosis 2019 Mar 3;284:102-109. Epub 2019 Mar 3.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, South Korea.

Background And Aims: There are limited data comparing clinical outcomes among new-generation drug-eluting stents (DES) in ST-segment elevation myocardial infarction (STEMI) patients with multivessel coronary artery disease (MVD) who underwent primary percutaneous coronary intervention (PCI) with culprit-only or multivessel PCI. We investigated 1-year clinical outcomes between biodegradable-polymer (BP)-coated biolimus-eluting stent (BES) and durable-polymer (DP)-coated DES in STEMI patients with MVD who underwent two different reperfusion strategies.

Methods: A total of 4255 patients were enrolled and divided into two groups, a culprit-only (n = 2571, BP- [n = 264] or DP-DES [n = 2307]) or a multivessel PCI group (n = 1684, BP- [n = 145] or DP-DES [n = 1539]). Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.022DOI Listing
March 2019
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Enhanced outcomes for coronary artery disease obtained by a multidisciplinary heart team approach.

Gen Thorac Cardiovasc Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiovascular Medicine, St. Luke's International Hospital, Tokyo, Japan.

Background: We implemented our multidisciplinary heart team (MHT) approach since 2012 for patients with coronary artery disease (CAD) and assessed the effectiveness of it by comparing outcomes in patients treated before and after the introduction of the MHT approach.

Methods: Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for CAD were performed in 802 and 57 patients from 2009 to 2011 in Group NH, and were performed in 867 and 160 patients from 2012 to 2014 in Group H, respectively. The primary outcome was major adverse cardiovascular and cerebrovascular events (MACCE), defined as the composite of all-cause death, myocardial infarction, stroke, cardiac-related readmission and target vessel repeat revascularisation (TVR) for PCI or revascularisation on grafted vessels for CABG. Read More

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http://dx.doi.org/10.1007/s11748-019-01108-4DOI Listing
March 2019
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Cell signaling and biological pathway in cardiovascular diseases.

Arch Pharm Res 2019 Mar 15. Epub 2019 Mar 15.

National Research Laboratory for Stem Cell Niche, Center for Medical Innovation, Seoul National University Hospital, Seoul, 110-744, Republic of Korea.

Currently, coronary artery disease accounts for a large proportion of deaths occurring worldwide. Damage to the heart muscle over a short period of time leads to myocardial infarction (MI). The biological mechanisms of atherosclerosis, one of the causes of MI, have been well studied. Read More

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http://dx.doi.org/10.1007/s12272-019-01141-0DOI Listing

Initial experience with regadenoson stress positron emission tomography in patients with left bundle branch block: Low prevalence of septal defects and high accuracy for obstructive coronary artery disease.

J Nucl Cardiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Cardiovascular Imaging, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, USA.

Background: Assessing for coronary artery disease (CAD) in patients with left bundle branch block (LBBB) is difficult with noninvasive cardiac imaging. Few studies report the prevalence of LBBB associated septal-apical perfusion defects using regadenoson stress on Positron Electron Tomography (PET) imaging.

Methods And Results: We identified 101 consecutive patients with baseline LBBB, and without known CAD, who underwent rest-stress regadenoson PET. Read More

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http://dx.doi.org/10.1007/s12350-019-01681-4DOI Listing

Semaphorin 3F Promotes Transendothelial Migration of Leukocytes in the Inflammatory Response After Survived Cardiac Arrest.

Inflammation 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.

Leukocyte transmigration through the blood vessel wall is a fundamental step of the inflammatory response and requires expression of adhesion molecule PECAM-1. Accumulating evidence implicates that semaphorin (Sema) 3F and its receptor neuropilin (NRP) 2 are central regulators in vascular biology. Herein, we assess the role of Sema3F in leukocyte migration in vitro and in vivo. Read More

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http://dx.doi.org/10.1007/s10753-019-00985-4DOI Listing

2018 Cholesterol Guidelines: Key Topics in Primary Prevention.

Curr Atheroscler Rep 2019 Mar 16;21(5):17. Epub 2019 Mar 16.

Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.

Purpose Of Review: The 2018 American College of Cardiology (ACC) and American Heart Association (AHA) cholesterol guidelines are a comprehensive update providing recommendations for management of patients with high blood cholesterol based on the best available evidence. This review highlights key topics clinicians need to know for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) based on the 2018 ACC/AHA cholesterol guidelines.

Recent Findings: The guidelines include a broad framework for risk estimation and management for primary prevention of ASCVD. Read More

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http://dx.doi.org/10.1007/s11883-019-0776-8DOI Listing

Non-invasive assessment of myocardial perfusion in different blood pressure phenotypes and its association with arterial stiffness indices.

Am J Hypertens 2019 Mar 16. Epub 2019 Mar 16.

3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: We investigated for the first time whether patients with recent-onset, uncomplicated hypertension and different hypertension phenotypes exhibit altered values of SEVR, a surrogate measure of myocardial perfusion that correlates with the ratio of subendocardial to subepicardial blood flow. We additionally explored whether SEVR correlates with arterial stiffness in a population free from the long-term effects of essential hypertension.

Methods: Non-treated individuals free from any known health problems were classified as true hypertensives (TH), white-coat hypertensives (WCH), masked hypertensives (MH) and normotensives. Read More

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http://dx.doi.org/10.1093/ajh/hpz039DOI Listing

Implications of the local haemodynamic forces on the phenotype of coronary plaques.

Heart 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiology, Bern University Hospital, Bern, Switzerland.

Aim: To examine the effect of endothelial shear stress (ESS) on the dynamic changes in plaque phenotype.

Methods: Patients with myocardial infarction that had intravascular ultrasound-virtual histology (IVUS-VH) and optical coherence tomography (OCT) at baseline and 13-month follow-up were studied. The IVUS-VH data were used to reconstruct the nonculprit vessels, and in the obtained models the ESS was estimated in 3 mm segments. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314086DOI Listing

Nutrition, Obesity and Cachexia in Patients with Heart Failure: A Consensus Statement from the HFSA Scientific Statements Committee.

J Card Fail 2019 Mar 12. Epub 2019 Mar 12.

Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and fluid intake restriction, but dietary quality is frequently poor in patients with HF and may contribute to morbidity and mortality. Restrictive dietary counselling can lead to inadequate intake of macronutrients and micronutrients by patients with HF, with the potential for deficiencies of calcium, magnesium, zinc, iron, thiamine, vitamins D, E, K, and folate. Although inadequate intake and low plasma levels of micronutrients have been associated with adverse clinical outcomes, evidence supporting therapeutic repletion is limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10719164183091
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http://dx.doi.org/10.1016/j.cardfail.2019.03.007DOI Listing
March 2019
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The emerging concept of "individualized cholesterol-lowering therapy": A change in paradigm.

Pharmacol Ther 2019 Mar 12. Epub 2019 Mar 12.

Klinik für Innere Medizin I, Universitätsklinikum Jena, Jena, Germany. Electronic address:

High LDL-cholesterol concentrations constitute a risk for atherosclerotic cardiovascular disease. By consensus, cholesterol-lowering therapy is initiated with a statin that reduces endogenous cholesterol synthesis, upregulates hepatic LDL receptor activity, increases LDL clearance and lowers LDL-cholesterol concentrations in the bloodstream. The efficacy of statin treatment is dose dependent and achieves a risk reduction of up to 50%. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2019.03.004DOI Listing

Bioresorbable vascular scaffolds for percutaneous treatment of chronic total coronary occlusions: a meta-analysis.

BMC Cardiovasc Disord 2019 Mar 15;19(1):59. Epub 2019 Mar 15.

Kardiologie I, Zentrum für Kardiologie, University Medical Center Mainz and DZHK Standort Rhein-Main, Mainz, Germany.

Background: BRS represent a new approach to treating coronary artery disease. Beneficial properties of BRS regarding the restoration of vasomotility after resorption make them attractive devices in CTO revascularization. However, experience in this setting is limited. Read More

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http://dx.doi.org/10.1186/s12872-019-1042-2DOI Listing

Gout is associated with a higher risk of chronic renal disease in older adults: a retrospective cohort study of U.S. Medicare population.

BMC Nephrol 2019 Mar 15;20(1):93. Epub 2019 Mar 15.

Department of Medicine at School of Medicine, University of Alabama at Birmingham, 1720 Second Ave. South, Birmingham, AL, 35294-0022, USA.

Background: Hyperuricemia and gout have been linked to chronic kidney disease (CKD). Whether the increased risk of CKD in gout is due to shared risk factors such as hypertension, diabetes or heart disease, or due to gout itself is not known. Studies in older adults, who tend to have a high incidence of CKD, are limited. Read More

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http://dx.doi.org/10.1186/s12882-019-1274-5DOI Listing

Thrombectomy and reconstruction of the left vertebral artery after total arch replacement: never give up on postoperative stroke.

Gen Thorac Cardiovasc Surg 2019 Mar 14. Epub 2019 Mar 14.

Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.

The patient was a 64-year-old man who had aortic regurgitation, ischemic heart disease, a transverse aortic aneurysm, and an abdominal-common iliac aneurysm. Concomitant operations including aortic valve replacement, coronary artery bypass grafting, and total aortic arch replacement with elephant trunk technique were performed successfully. The patient developed postoperative cardiac tamponade on the 5th postoperative day, resulting in bulbar palsy due to occlusion of the dominant left vertebral artery. Read More

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http://dx.doi.org/10.1007/s11748-019-01106-6DOI Listing

Lipoprotein(a) apheresis in patients with peripheral arterial disease: rationale and clinical results.

Clin Res Cardiol Suppl 2019 Mar 15. Epub 2019 Mar 15.

Department of Medicine III-Lipidology and Center for Extracorporeal Treatment, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Patients with symptomatic peripheral arterial disease (PAD) are at a very high risk of cardiovascular morbidity and mortality. Elevated lipoprotein(a) levels have been shown to be a risk factor for coronary artery disease (CAD) and stroke. More recently elevated lipoprotein(a) levels have also been demonstrated to be associated with prevalent and incident PAD, and even may be a stronger risk factor for PAD compared with CAD. Read More

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http://dx.doi.org/10.1007/s11789-019-00097-1DOI Listing

Incremental value of stress echocardiography and computed tomography coronary calcium scoring for the diagnosis of coronary artery disease.

Int J Cardiovasc Imaging 2019 Mar 14. Epub 2019 Mar 14.

Division of Cardiovascular Medicine, Clemenceau Medical Center, PO BOX 11-2555, Beirut, Lebanon.

Computed tomography coronary angiography (CTCA) has a higher negative predictive value (NPV) for coronary artery disease (CAD) than stress echocardiography (SE). CT calcium scoring (CTCS) allows detection and quantification of coronary artery calcification (CAC). The NPV of combined SE and CTCS for CAD is not well defined. Read More

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http://dx.doi.org/10.1007/s10554-019-01577-xDOI Listing

Huge coronary artery aneurysm causing myocardial infarction in Behcet disease.

Eur Heart J Cardiovasc Imaging 2019 Mar 14. Epub 2019 Mar 14.

Division of Cardiology, Department of Internal medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Bucheon 14584, South Korea.

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https://academic.oup.com/ehjcimaging/advance-article/doi/10.
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http://dx.doi.org/10.1093/ehjci/jez037DOI Listing
March 2019
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An unusual thrombosis of an ostial left internal mammary artery graft causing acute coronary syndrome five years after coronary bypass surgery.

Turk Kardiyol Dern Ars 2019 Mar;47(2):137-139

Department of Cardiology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.

For long-term patency, a left internal mammary artery (LIMA) graft is considered the gold standard for left anterior descending artery (LAD) revascularization. Subsequent occlusion of a LIMA graft may be related to atherosclerosis, narrowing at anastomotic locations, fixed torsions within the graft, straight tubular stenosis, dissection, or vasospasm. Late thrombotic occlusion of a LIMA, however, is rare, and the cause is not known, though case reports can be found in the literature. Read More

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http://dx.doi.org/10.5543/tkda.2018.71643DOI Listing

Coronary artery disease associated with factor V Leiden mutation: a case report.

Turk Kardiyol Dern Ars 2019 Mar;47(2):148-152

Federal University of Rio de Janeiro, Edson Saad Heart Institute, Rio de Janeiro, RJ, Brasil.

The prevalence of coronary artery disease in young adults (<45 years of age) has been increasing steadily in recent decades. Although traditional cardiovascular risk factors can be identified in most cases, newly recognized associations are becoming progressively more relevant. The relationship between the factor V Leiden mutation and atherosclerosis has been a matter of debate due to conflicting data presented in previous studies. Read More

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http://archivestsc.com/jvi.aspx?un=TKDA-39939
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http://dx.doi.org/10.5543/tkda.2018.39939DOI Listing
March 2019
1 Read

Big Health Data and Cardiovascular Diseases: A Challenge for Research, an Opportunity for Clinical Care.

Front Med (Lausanne) 2019 25;6:36. Epub 2019 Feb 25.

Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.

Cardiovascular disease (CVD) accounts for the majority of death and hospitalization, health care expenditures and loss of productivity in developed country. CVD research, thus, plays a key role for improving patients' outcomes as well as for the sustainability of health systems. The increasing costs and complexity of modern medicine along with the fragmentation in healthcare organizations interfere with improving quality care and represent a missed opportunity for research. Read More

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http://dx.doi.org/10.3389/fmed.2019.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401640PMC
February 2019
2 Reads

Chronic spontaneous coronary artery dissection in association with antiphospholipid syndrome presenting as stable angina.

BMJ Case Rep 2019 Mar 14;12(3). Epub 2019 Mar 14.

Department of Cardiology, University Hospital Limerick, Limerick, Ireland.

A 52-year-old man presented to our cardiology service for an elective diagnostic coronary angiogram for risk stratification in the context of stable angina. He was diagnosed with antiphospholipid syndrome 2 years prior and had three known thrombotic episodes in the form of a stroke, retinal artery occlusion and deep vein thrombosis. Our initial differential was atherosclerotic coronary artery disease, however, coronary angiography demonstrated a dominant right coronary artery with a long segment of chronic spontaneous dissection distally but with thrombolysis in myocardial infarction III flow. Read More

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http://dx.doi.org/10.1136/bcr-2018-227674DOI Listing

Recovery of Rate-Pressure Product and Cardiac Mortality in Coronary Artery Disease Patients with Type 2 Diabetes.

Diabetes Res Clin Pract 2019 Mar 11. Epub 2019 Mar 11.

Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

Aims: To investigate prognostic significance of post-exercise recovery of rate-pressure product (RPP) in patients with stable coronary artery disease (CAD) and type 2 diabetes (T2D).

Methods: Patients with angiographically documented CAD and T2D (n=697) underwent symptom-limited bicycle exercise test. Exercise capacity (EC), heart rate, blood pressure and RPP responses to peak exercise and recovery (2' and 5' after cessation of exercise) were analyzed. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.007DOI Listing

Subclinical thyroid dysfunction and cardiovascular consequences: An alarming wake-up call?

Trends Cardiovasc Med 2019 Mar 5. Epub 2019 Mar 5.

School of Medicine, Athens University, Athens, Greece. Electronic address:

Subclinical thyroid dysfunction (STD), presenting as subclinical hypothyroidism (SHypo) or subclinical hyperthyroidism (SHyper), defined as abnormal serum thyrotropin (TSH) and normal free thyroid hormones, is associated with increased cardiovascular (CV) risk and mortality. Depending on the degree of such dysfunction, atherosclerosis, coronary artery disease, heart failure and cardiac arrhythmias, predominantly atrial fibrillation, characterize both disorders and increase CV and total mortality compared to euthyroid persons. There are some differences in the mechanisms involved in the increased CV risk incurred by each type of STD, with more traditional CV risk factors clustered in SHypo than in SHyper, while the role of the TSH or its absence thereof, together with the respective, even subtle, changes incurred in thyroid hormone concentrations, seem to adversely influence the CV system in both types of STD. Read More

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http://dx.doi.org/10.1016/j.tcm.2019.02.011DOI Listing

Is epicardial fat attenuation a novel marker of coronary inflammation?

Atherosclerosis 2019 Mar 2. Epub 2019 Mar 2.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University Hospital Essen, Essen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00219150193011
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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.023DOI Listing
March 2019
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Impact of coronary angiography early after CABG for suspected postoperative myocardial ischemia.

J Cardiothorac Surg 2019 Mar 12;14(1):54. Epub 2019 Mar 12.

Department of Cardiothoracic Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

Background: The incidence of perioperative myocardial infarction is reported to 2-8%. The aim of the study (retrospectively registered) was to evaluate whether control coronary angiography after surgery is useful in case of suspected postoperative myocardial ischemia.

Methods: All patients who demonstrated signs of myocardial ischemia post CABG and underwent coronary angiography from 6/2008 to 06/2015 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s13019-019-0876-0DOI Listing

Upcoding of Clinical Information to Meet Appropriate Use Criteria for Percutaneous Coronary Intervention.

Circ Cardiovasc Qual Outcomes 2019 Mar;12(3):e005025

International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., D.P.F.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005025DOI Listing

Balancing the Benefits, Risks, and Costs of Chronic Total Occlusion Percutaneous Coronary Intervention.

Circ Cardiovasc Interv 2019 Mar;12(3):e007809

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.007809DOI Listing

Risk of Ischemic Stroke and Peripheral Arterial Disease in Heterozygous Familial Hypercholesterolemia: A Meta-Analysis.

Angiology 2019 Mar 14:3319719835433. Epub 2019 Mar 14.

1 Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Heterozygous familial hypercholesterolemia (HeFH) is a common genetic disorder predisposing affected individuals to lifelong low-density lipoprotein cholesterol (LDL-C) elevation and coronary heart disease. However, whether HeFH increases the risk of peripheral arterial disease (PAD) and ischemic stroke is undetermined. We examined associations between HeFH and these outcomes in a comprehensive systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1177/0003319719835433DOI Listing

Statin and clinical outcomes of primary prevention in individuals aged >75 years: The SCOPE-75 study.

Atherosclerosis 2019 Mar 4;284:31-36. Epub 2019 Mar 4.

Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

Background And Aims: Limited data is available on the benefit of statin for primary prevention in the elderly. The aim of this study is to investigate whether statin for primary prevention is effective in lowering the cardiovascular risk and all-cause death in individuals aged >75 years.

Methods: This was a retrospective, propensity score-matched study and data were acquired between 2005 and 2016 in a tertiary university hospital. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.026DOI Listing

Remnant cholesterol and coronary atherosclerotic plaque burden assessed by computed tomography coronary angiography.

Atherosclerosis 2019 Mar 4;284:24-30. Epub 2019 Mar 4.

Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia; Department of Medicine, Monash University, Clayton, Victoria, Australia; Mildura Cardiology, Mildura, Victoria, Australia; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. Electronic address:

Background And Aims: There remains a substantial residual risk of ischaemic heart disease (IHD) despite optimal low-density lipoprotein cholesterol (LDLC) reduction. Part of this risk may be attributable to remnant cholesterol, which is carried in triglyceride-rich lipoproteins. We evaluated the relationship between remnant cholesterol and coronary atherosclerotic plaque burden assessed non-invasively by computed tomography coronary angiography (CTCA) in patients with suspected coronary artery disease (CAD). Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.019DOI Listing
March 2019
3.994 Impact Factor

Optimisation of laboratory methods for whole transcriptomic RNA analyses in human left ventricular biopsies and blood samples of clinical relevance.

PLoS One 2019 14;14(3):e0213685. Epub 2019 Mar 14.

National Heart and Lung Institute, ICTEM, The Hammersmith Hospital, Imperial College London, London, United Kingdom.

This study aimed to optimise techniques for whole transcriptome and small RNA analyses on clinical tissue samples from patients with cardiovascular disease. Clinical samples often represent a particular challenge to extracting RNA of sufficient quality for robust RNA sequencing analysis, and due to availability, it is rarely possible to optimise techniques on the samples themselves. Therefore, we have used equivalent samples from pigs undergoing cardiopulmonary bypass surgery to test different protocols for optimal RNA extraction, and then validated the protocols in human samples. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213685PLOS

Risk factors for chemotherapy-related cardiac toxicity.

Curr Opin Cardiol 2019 Mar 11. Epub 2019 Mar 11.

Department of Medicine, University of Chicago Medicine, Chicago, Illinois, USA.

Purpose Of Review: The purpose of this review is to discuss the clinical and treatment-related factors that increase the risk of cardiotoxicity with anthracyclines and human epidermal growth factor 2 receptor inhibitors.

Recent Findings: Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy. Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000619DOI Listing

Factors Associated With Disease Damage in Puerto Ricans With Primary Sjögren Syndrome.

J Clin Rheumatol 2019 Mar 12. Epub 2019 Mar 12.

From the Division of Rheumatology, Department of Medicine, and.

Objective: The aim of this study was to determine the association of demographic parameters, clinical manifestations, disease activity, and pharmacologic therapy with disease damage in a group of Puerto Ricans with primary Sjögren syndrome (pSS).

Methods: A cross-sectional study was conducted in 100 Hispanics of Puerto Rico with pSS. Patients were 21 years or older and fulfilled the 2012 American College of Rheumatology classification criteria for pSS. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001023DOI Listing
March 2019
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Does the benefit from treating to lower blood pressure targets vary with age? A systematic review and meta-analysis.

J Hypertens 2019 Mar 11. Epub 2019 Mar 11.

Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Background: Recommendations differ regarding how blood pressure targets should vary with age. Crucial to this controversy is whether treatment benefit varies with age.

Methods: Systematic searches were conducted for trials randomizing treatment in intensive arms to the recommended SBP targets: 120-140 mmHg. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002079DOI Listing

Relationship between Perioperative Hypotension and Perioperative Cardiovascular Events in Patients with Coronary Artery Disease Undergoing Major Noncardiac Surgery.

Anesthesiology 2019 Mar 8. Epub 2019 Mar 8.

From the Lilibeth Caberto London Kidney Clinical Research Unit, London Health Sciences Centre, London, Canada (P.S.R.) the Department of Medicine, McMaster University, Hamilton, Canada (P.S.R., T.S., E.D., V.T., P.J.D.) Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada(P.S.R., E.D., P.J.D.) the Population Health Research Institute, Hamilton, Canada (E.D., P.J.D.) the Division of General Internal Medicine, McGill University Health Center, Montreal, Canada (A.B.) the Department of Anesthesia and Intensive Care, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China (M.T.V.C.) the Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada (C.B.) the Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada (B.J.W.C.) the Department of Radiology, University of Ottawa, Ottawa, Canada (B.J.W.C.) the Department of Anesthesia, University of Toronto, Toronto, Canada (J.S.K).

What We Already Know About This Topic: Perioperative hypotension is associated with cardiovascular events in patients having noncardiac surgery, but it is unknown if the severity of preexisting coronary artery disease determines susceptibility to the cardiovascular risks of perioperative hypotension WHAT THIS ARTICLE TELLS US THAT IS NEW: In patients who had risk factors for, or known, coronary artery disease and were having noncardiac surgery, perioperative hypotension and degree of coronary artery disease on preoperative coronary computed tomographic angiography were independently associated with perioperative cardiovascular death and myocardial infarctionPerioperative hypotension was associated with cardiovascular events regardless of the degree of coronary artery disease on preoperative coronary computed tomographic angiography BACKGROUND:: Perioperative hypotension is associated with cardiovascular events in patients having noncardiac surgery. It is unknown if the severity of preexisting coronary artery disease determines susceptibility to the cardiovascular risks of perioperative hypotension.

Methods: In this retrospective exploratory analysis of a substudy of an international prospective blinded cohort study, 955 patients 45 yr of age or older with history or risk factors for coronary artery disease underwent coronary computed tomographic angiography before elective inpatient noncardiac surgery. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002654DOI Listing

Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase-Activating-Protein (AZD5718) for Treatment of Coronary Artery Disease.

J Med Chem 2019 Mar 14. Epub 2019 Mar 14.

5-lipoxygenase activating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway activity and reduce the production of pro-inflammatory and vasoactive leukotrienes. As such, they are hypothesized to have therapeutic benefit for the treatment of diseases that involve chronic inflammation including coronary artery disease. Herein, we disclose the medicinal chemistry discovery and the early clinical development of the FLAP inhibitor AZD5718 (12). Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b02004DOI Listing
March 2019
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[Secondary cardiovascular prevention strategies].

Authors:
François Ledru

Rev Prat 2018 Apr;68(4):439-445

Service de réadaptation cardiaque et prévention cardiovasculaire, hôpital Corentin-Celton, Issy-les-Moulineaux, France.

Secondary cardiovascular prevention strategies. Patients with a documented peripheral or coronary artery disease, subclinical atheroma, diabetes associated with target organ damage or a major risk factor or severe kidney failure have a risk of cardiovascular death above 10% in the next 10 years. They all should be helped to adopt a healthier life style and be prescribed a targeted polytherapy. Read More

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Interventions to support return to work for people with coronary heart disease.

Cochrane Database Syst Rev 2019 Mar 14;3:CD010748. Epub 2019 Mar 14.

Institute and Policlinic of Occupational and Social Medicine, Faculty of Medicine Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, Dresden, Germany, 01307.

Background: People with coronary heart disease (CHD) often require prolonged absences from work to convalesce after acute disease events like myocardial infarctions (MI) or revascularisation procedures such as coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Reduced functional capacity and anxiety due to CHD may further delay or prevent return to work.

Objectives: To assess the effects of person- and work-directed interventions aimed at enhancing return to work in patients with coronary heart disease compared to usual care or no intervention. Read More

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http://doi.wiley.com/10.1002/14651858.CD010748.pub2
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http://dx.doi.org/10.1002/14651858.CD010748.pub2DOI Listing
March 2019
2 Reads

DeepTACT: predicting 3D chromatin contacts via bootstrapping deep learning.

Nucleic Acids Res 2019 Mar 14. Epub 2019 Mar 14.

MOE Key Laboratory of Bioinformatics, Bioinformatics Division and Center for Synthetic and Systems Biology, BNRist, Department of Automation, Tsinghua University, Beijing 100084, China.

Interactions between regulatory elements are of crucial importance for the understanding of transcriptional regulation and the interpretation of disease mechanisms. Hi-C technique has been developed for genome-wide detection of chromatin contacts. However, unless extremely deep sequencing is performed on a very large number of input cells, which is technically limited and expensive, current Hi-C experiments do not have high enough resolution to resolve contacts between regulatory elements. Read More

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
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http://dx.doi.org/10.1093/nar/gkz167DOI Listing
March 2019
4 Reads
9.112 Impact Factor

Vorapaxar for secondary prevention in the elderly with peripheral artery disease: Insights from the TRA 2°P-TIMI 50 trial.

Vasc Med 2019 Mar 14:1358863X19826681. Epub 2019 Mar 14.

2 TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1177/1358863X19826681DOI Listing

[Regularity of traditional Chinese medicine prescriptions for same treatment for cardiovascular and cerebrovascular diseases].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(1):193-198

Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine Tianjin 300193,China Research and Development Center of Traditional Chinese Medicine,Tianjin International Joint Academy of Biotechnology & Medicine Tianjin 300457,China.

To explore the regularity of traditional Chinese medicine(TCM) prescriptions for cardio-cerebrovascular diseases,the core drug groups with common therapeutic effects on cerebrovascular diseases represented by stroke and cardiovascular diseases represented by coronary artery disease were extracted,and their consistency and difference in the treatment of different diseases were analyzed.A total of 388 Chinese patent medicines were collected for the treatment of cerebrovascular diseases,cardiovascular diseases and cardio-cerebrovascular diseases.The dominant and recessive patterns of Chinese patent medicines in clinical use were found by "frequency analysis","compatibility analysis" and "network analysis" respectively. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181101.007DOI Listing
January 2019