181,365 results match your criteria Coronary Artery Atherosclerosis

The impact of visceral fat and levels of vitamin D on coronary artery calcification.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):88-93

Universidade de Pernambuco, Faculdade de Ciências Médicas - Recife (PE), Brasil.

Objective: To evaluated calcification of the coronary arteries and its association with visceral fat and 25-hydroxyvitamin D (25(OH)D) serum levels.

Methods: A cross sectional study involving 140 individuals without any previous diagnosis of cardiovascular disease. A biochemical analysis of vitamin D serum levels was carried out, as well as computed tomography to measure coronary artery calcium score and visceral adipose tissue. Read More

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January 2021

Prevalence of Coronary Artery Disease and Coronary Microvascular Dysfunction in Patients With Heart Failure With Preserved Ejection Fraction.

JAMA Cardiol 2021 Jun 23. Epub 2021 Jun 23.

British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.

Importance: Coronary artery disease (CAD) and coronary microvascular dysfunction (CMD) may contribute to the pathophysiologic characteristics of heart failure with preserved ejection fraction (HFpEF). However, the prevalence of CAD and CMD have not been systematically studied.

Objective: To examine the prevalence of CAD and CMD in hospitalized patients with HFpEF. Read More

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Cadmium Exposure and Coronary Artery Atherosclerosis: A Cross-Sectional Population-Based Study of Swedish Middle-Aged Adults.

Environ Health Perspect 2021 Jun 23;129(6):67007. Epub 2021 Jun 23.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The general population is ubiquitously exposed to the toxic metal cadmium through the diet and smoking. Cadmium exposure is associated with increased morbidity and mortality in myocardial infarction and stroke. Atherosclerosis is the main underlying mechanism of myocardial infarction. Read More

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Response shift after coronary revascularization.

Qual Life Res 2021 Jun 22. Epub 2021 Jun 22.

Department of Medical Psychology, Amsterdam University Medical Centers, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, Netherlands.

Purpose: The aims of this study were to investigate (1) the extent to which response shift occurs among patients with coronary artery disease (CAD) after coronary revascularization, (2) whether the assessment of changes in health-related quality of life (HRQoL), controlled for response shift, yield more valid estimates of changes in HRQoL, as indicated by stronger associations with criterion measures of change, than without controlling for response shift, and (3) if occurrences of response shift are related to patient characteristics.

Methods: Patients with CAD completed the SF-36 and the Seattle Angina Questionnaire (SAQ7) at baseline and 3 months after coronary revascularization. Sociodemographic, clinical and psychosocial variables were measured with the patient version of the New York Heart Association-class, Subjective Significance Questionnaire, Reconstruction of Life Events Questionnaire (RE-LIFE), and HEXACO personality inventory. Read More

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The Most Common Clinical Features of Kawasaki Disease Patients in King Abdulaziz Medical City.

Cureus 2021 May 19;13(5):e15127. Epub 2021 May 19.

Cardiology, King Abdulaziz University Faculty of Medicine, Jeddah, SAU.

Background Kawasaki disease (KD) is an acute idiopathic vasculitis affecting the small and medium-sized arteries especially coronary artery (CA). it occurs in childhood mostly below five years of age. Objective This study aims to identify the most common clinical features among KD patients in King Abdulaziz Medical City in Jeddah, Saudi Arabia from 1/1/1982 to 31/12/2018. Read More

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Peripheral Artery Disease as a Predictor of Coronary Artery Disease in Patients Undergoing Coronary Angiography.

Cureus 2021 May 18;13(5):e15094. Epub 2021 May 18.

Family Medicine, Jinnah Post Graduate Medical Center, Karachi, PAK.

Background Peripheral artery disease (PAD) may be a useful tool to predict coronary artery disease (CAD) in patients undergoing coronary angiography. If proven that PAD can be a good predictor of CAD, it can help in early and cost-effective diagnosis of CAD. Methodology This observational study was conducted from January 2020 to February 2021 in the cardiology unit of a tertiary care hospital. Read More

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The Management of Coronary Artery Disease in Ethiopia: Emphasis on Revascularization.

Ethiop J Health Sci 2021 Mar;31(2):439-454

MD, Internist, Interventional Cardiologist, Associate Professor of Medicine, Addis Ababa University.

Cardiovascular diseases are number one cause of death worldwide. Over half of the cardiovascular diseases, 51%, are due to coronary artery disease. Coronary artery disease is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial coronary arteries. Read More

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Activation of Aryl Hydrocarbon Receptor by ITE Improves Cardiac Function in Mice After Myocardial Infarction.

J Am Heart Assoc 2021 Jun 23:e020502. Epub 2021 Jun 23.

Division of Cardiology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Republic of Korea.

Background The immune and inflammatory responses play a considerable role in left ventricular remodeling after myocardial infarction (MI). Binding of AhR (aryl hydrocarbon receptor) to its ligands modulates immune and inflammatory responses; however, the effects of AhR in the context of MI are unknown. Therefore, we evaluated the potential association between AhR and MI by treating mice with a nontoxic endogenous AhR ligand, ITE (2-[1'H-indole-3'-carbonyl]-thiazole-4-carboxylic acid methyl ester). Read More

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Ordered multi-path propagation for vessel centerline extraction.

Phys Med Biol 2021 Jun 22. Epub 2021 Jun 22.

School of Optics and Photonics, Beijing Institute of Technology, NO.5 Zhongguancun south street, Beijing, 100081, CHINA.

Vessel centerline extraction from x-ray angiography (XRA) images is essential for vessel structure analysis in the diagnosis of coronary artery disease. However, complete and continuous centerline extraction remains a challenging task due to image noise, poor contrast, and complexity of vessel structure. Thus, an iterative multi-path search framework for automatic vessel centerline extraction is proposed. Read More

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Physiological Traits and Adherence to Therapy of Sleep Apnea in Individuals with Coronary Artery Disease.

Am J Respir Crit Care Med 2021 Jun 22. Epub 2021 Jun 22.

Brigham and Women's Hospital, 1861, Boston, Massachusetts, United States.

Rationale: Untreated obstructive sleep apnea (OSA) is associated with adverse outcomes in patients with coronary artery disease (CAD). Continuous positive airway pressure (CPAP) is the most common treatment, but despite interventions addressing established adherence determinants, CPAP use remains poor.

Objectives: To determine whether physiological traits that cause OSA are associated with long-term CPAP adherence in patients with CAD. Read More

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Predictive ability of coronary computed tomography angiography parameters in patients suspected of obstructive coronary artery disease: a single-center cross-sectional study.

Eur Rev Med Pharmacol Sci 2021 Jun;25(11):4074-4085

Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Objective: Coronary computed tomography angiography (CCTA) is becoming increasingly useful for the diagnosis of coronary artery disease (CAD). Coronary calcium score (CCS), epicardial fat volume (EFV), and number of coronary plaques (NoP) add important information for the risk stratification and prognosis prediction of these patients. However, evidence about their ability to predict obstructive CAD is limited. Read More

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ApoB gene polymorphism (rs676210) and its pharmacogenetics impact on atorvastatin response among Iraqi population with coronary artery disease.

J Genet Eng Biotechnol 2021 Jun 22;19(1):95. Epub 2021 Jun 22.

College of Biotechnology, Al-Nahrain University, Baghdad, Iraq.

Background: Drug response is below genetic influence, proven by the genetic variants. Pharmacogenetics trials are performed in many diseases, including coronary artery disease. This study was designed to determine the genetic polymorphism (rs676210) Pro2739leu G > A in the lipid metabolism-related gene (ApoB gene) and its pharmacogenetic role in the response to atorvastatin drug in a sample of Iraqi population with coronary artery disease (CAD). Read More

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Variation of computed tomographic angiography-based fractional flow reserve after transcatheter aortic valve implantation.

Eur Radiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Cardiology, West China Hospital, Sichuan University, #37 Guo Xue Alley, Chengdu, 610041, China.

Objectives: We sought to identify the impact of transcatheter aortic valve implantation (TAVI) on changes of fractional flow reserve computed tomography (FFR) values and the associated clinical impact.

Methods: A retrospective analysis was done with CT obtained pre-TAVI, prior to hospital discharge and at 1-year follow-up, which provided imaging sources for the calculation of FFR values based on an online platform.

Results: A total of 190 patients were enrolled. Read More

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Ten-year clinical outcomes of polymer-free versus durable polymer new-generation drug-eluting stent in patients with coronary artery disease with and without diabetes mellitus : Results of the Intracoronary Stenting and Angiographic Results: Test Efficacy of Sirolimus- and Probucol- and Zotarolimus-Eluting Stents (ISAR-TEST 5) trial.

Clin Res Cardiol 2021 Jun 22. Epub 2021 Jun 22.

Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, an der Technischen Universität München, Lazarettstrasse 36, 80636, Munich, Germany.

Background: Very long-term outcomes according to diabetic status of patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) with new-generation drug-eluting stents (DES) are scant. Both, the durable polymer zotarolimus-eluting stent (DP-ZES), the first DES to gain FDA-approval for specific use in patients with diabetes mellitus, and the polymer-free sirolimus- and probucol-eluting stent (PF-SES), with a unique design that enables effective drug release without the need of a polymer offer the potential to enhance clinical long-term outcomes especially in patients with diabetes mellitus.

Methods: We investigate 10-year clinical outcomes of the prespecified subgroups of patients with and without diabetes mellitus, randomly assigned to treatment with PF-SES versus DP-ZES in the ISAR-TEST 5 trial. Read More

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Transcatheter Treatment of Valvular Heart Disease: A Review.

JAMA 2021 Jun;325(24):2480-2494

Bluhm Cardiovascular Institute and Departments of Medicine and Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Importance: More than 40 million people are living with either mitral or aortic valve disease worldwide, and more than 180 000 heart valve replacement surgeries are performed each year in the US. Transcatheter valve repair has emerged as an important therapeutic option for patients who are candidates for heart valve replacement.

Observations: All transcatheter valve therapies involve a multidisciplinary team of interventional cardiologists, cardiothoracic surgeons, radiologists, echocardiographers, nurses, and social workers, termed the heart team, to determine the optimal approach for managing each patient. Read More

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Wiad Lek 2021 ;74(4):966-972


Objective: The aim: To investigate haematological and biochemical parameters and their potential for grading the severity of coronary artery lesions to predict the course atherosclerosis.

Patients And Methods: Materials and methods: The study is based on data obtained from a prospective analysis of 131 patients at the age of 51 to 82 years old from January to December 2019, whose complaints could indicate the coronary artery disease. All patients underwent a comprehensive clinical, laboratory and instrumental examination. Read More

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Return to flying after coronary artery disease: A case series among Malaysian pilots.

J Occup Health 2021 Jan;63(1):e12241

Institute of Aviation Medicine, Subang Air Base, Shah Alam, Selangor, Malaysia.

Objectives: Pilots with coronary artery disease (CAD) are at increased risk of myocardial infarction, stroke, and possibly death. Return to flying duties may be considered after a detailed risk assessment. The aim of this retrospective case series is to describe the return to flying duty process. Read More

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January 2021

Impact of lung function on cardiovascular diseases and cardiovascular risk factors: a two sample bidirectional Mendelian randomisation study.

Thorax 2021 Jun 21. Epub 2021 Jun 21.

School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Adminstrative Region, China.

Introduction: Observational studies suggested lung function is inversely associated with cardiovascular disease (CVD) although these studies could be confounded. We conducted a two sample Mendelian randomisation study using summary statistics from genome-wide association studies (GWAS) to clarify the role of lung function in CVD and its risk factors, and conversely the role of CVD in lung function.

Methods: We obtained genetic instruments for forced expiratory volume in 1 s (FEV: 260) and forced vital capacity (FVC: 320) from publicly available UK Biobank summary statistics (n=421 986) and applied to GWAS summary statistics for coronary artery disease (CAD) (n=184 305), stroke (n=446 696), atrial fibrillation (n=1 030 836) and heart failure (n=977 320) and cardiovascular risk factors. Read More

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Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: A multicentre cohort study.

Arch Cardiovasc Dis 2021 May 21. Epub 2021 May 21.

Université de Paris, PARCC, INSERM, 75015 Paris, France; Hôpital Européen Georges-Pompidou, AP-HP, Université de Paris, 75015 Paris, France.

Background: Although women account for up to half of patients hospitalized for coronavirus disease 2019 (COVID-19), no specific data have been reported in this population.

Aims: To assess the burden and impact of cardiovascular comorbidities in women with COVID-19.

Methods: All consecutive patients hospitalized for COVID-19 across 24 hospitals from 26 February to 20 April 2020 were included. Read More

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Short and long terms clinical outcomes of Paclitaxel drug-eluting balloons applied for de-novo coronary artery lesions in the context of acute coronary syndrome: A real world experience.

Indian Heart J 2021 May-Jun;73(3):385-386. Epub 2021 Mar 27.

FRCP Consultant Cardiologist Royal Albert Edward Infirmary, WWL NHS Trust, Wigan, UK.

A single-centre retrospective observational study aimed at observing the outcomes of using DEB in ACS patients. All-comer ninety patients were included with a follow-up of 12-36 months. DEBs were deployed successfully yielding TIMI 3 without significant coronary dissection. Read More

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Appropriateness of angiography for suspected coronary artery disease.

Indian Heart J 2021 May-Jun;73(3):376-378. Epub 2021 Apr 18.

Cardiovascular Research Center, Shahid Rajaei Educational and Medical Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:

The aim of this study was to assess the appropriate use of diagnostic catheterizations (DC) for the patients with suspected coronary artery disease performed in Iran. The Electronic Health Record System database and manual review of files were utilised to collect data between 2012 and 2014. Patients were categorized in three groups as appropriate, uncertain, and inappropriate usage of DC and the logistic regression was used to investigate the relationships between variables. Read More

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Pitfalls in comparison of coronary artery measurements of Indian population with different geographical area studies.

Indian Heart J 2021 May-Jun;73(3):347-352. Epub 2021 Apr 15.

Department of Cardiology Care Hospital, Banjara Hills, Hyderabad, 500034, India. Electronic address:

Introduction: Coronary artery disease (CAD) is the most common cause of morbidity and mortality especially in the developing countries. Coronary artery measurements (CAM) are the most important factor affecting the procedure and outcome of coronary angioplasty (PCI) as well as coronary by-pass operations (CABG). In this study, we aimed to establish a database for the normal CAM as well as for gender difference among the Indian population using quantitative coronary angiography (QCA) with an objective of assessing normal coronary vessel morphology of patients with normal coronaries. Read More

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Safety and effectiveness of percutaneous coronary intervention using rotational atherectomy and new-generation drug-eluting stents for calcified coronary artery lesions in patients with chronic kidney disease.

Indian Heart J 2021 May-Jun;73(3):342-346. Epub 2021 Apr 28.

Department of Cardiology, National Heart Foundation Hospital & Research Institute, Bangladesh.

Aim: Coronary artery calcification is an important factor influencing revascularisation outcomes in patients with chronic kidney disease (CKD). Lesion preparation using rotational atherectomy (RA) may help adequately modify calcified plaques and facilitate the achievement of optimal clinical outcomes in these patients. In this study, we assessed the safety and effectiveness of percutaneous coronary intervention (PCI) using RA followed by new-generation drug-eluting stent (DES) implantation in patients with CKD and calcified coronary artery disease (CAD). Read More

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The relation between QRS complex fragmentation and segmental abnormalities of the myocardial contractility in patients with coronary artery disease.

Indian Heart J 2021 May-Jun;73(3):325-330. Epub 2021 Mar 29.

Department of Cardiology, Hospital de Clínicas, Asunción National University (UNA), San Lorenzo, Paraguay.

Background: Fragmented QRS (fQRS) is defined as any QRS complex with duration of less than 120 ms (ms) and at least one notch in the R or S wave in two or more leads belonging to the same coronary territory. The fQRS represents a delay in ventricular conduction caused by a myocardial scar associated to arrhythmic events.

Methods: This is a descriptive, retrospective, cross-sectional study of a total of 123 patientsadmitted with ischemic heart disease. Read More

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Correlation between echocardiographic calcium score and coronary artery lesion severity on invasive coronary angiography.

Indian Heart J 2021 May-Jun;73(3):307-312. Epub 2021 Mar 24.

Dept. of Research, Poona Hospital & Research Centre, Pune, India. Electronic address:

Objectives: The direct correlation between Echocardiographic non-coronary calcium score (ECS) and lesion severity on invasive coronary angiography (ICA) is not reported. The aim of the present study was to find the correlation between ECS and Gensini score.

Methods: One hundred seventy patients aged ≥18 years posted for clinically indicated ICA were included. Read More

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Epidemiological and clinical profile, management and outcomes of young patients (≤40 years) with acute coronary syndrome: A single tertiary care center study.

Indian Heart J 2021 May-Jun;73(3):295-300. Epub 2021 Jan 17.

Department of Cardiology, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India. Electronic address:

Objective: To study the epidemiological and clinical profile, angiographic patterns, reasons for the delay in presentation, management, and outcomes of the acute coronary syndrome (ACS) in young patients (≤40yrs) presenting to a tertiary care hospital in North India.

Methods: We included a total of 182 patients aged ≤40 years and presenting with ACS to the cardiology critical care unit of our department from January 2018 to July 2019.

Results: The mean age of the study population was 35. Read More

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January 2021

CYP2C19 genotype-directed PY inhibitor antiplatelet therapy normalizes risk for major adverse cardiovascular events after percutaneous coronary intervention.

Indian Heart J 2021 May-Jun;73(3):281-288. Epub 2021 Mar 17.

Sanford Heart Hospital, Sanford Cardiovascular Institute, University of South Dakota Sanford School of Medicine, Sioux Falls, SD, USA.

Objective: To study the use of CYP2C19 genotyping to guide P2Y inhibitor selection to maximize efficacy, and attenuate risk in appropriate patients who underwent PCI for CAD.

Methods: We performed a retrospective analysis of 868 patients with CAD who received CYP2C19 genotyping after PCI and changed P2Y inhibitor based on the results. Patients were divided into two groups based on clopidogrel metabolizer status. Read More

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A novel algorithm for the computation of the diastolic pressure ratio in the invasive assessment of the functional significance of coronary artery disease.

Panminerva Med 2021 Jun;63(2):206-213

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University, Latina, Italy -

Background: Invasive functional assessment is a mainstay in the management of patients with coronary artery disease (CAD), but there is uncertainty on the comparative accuracy of diagnostic indices of functional significance. We aimed to validate the diagnostic performance of a novel non-hyperemic diastolic pressure ratio (dPR).

Methods: We performed a retrospective analysis including two separate registries (VERIFY 2, Latina, Italy) of patients in whom functional indices were measured for lesions with angiographically moderate severity. Read More

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Disparities between Asian and Non-Asian Thrombolyzed Acute Ischemic Stroke Patients in the Enhanced Control of Hypertension and Thrombolysis Stroke Trial.

Cerebrovasc Dis 2021 Jun 21:1-7. Epub 2021 Jun 21.

The George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, New South Wales, Australia.

Background And Purpose: As outcomes for acute ischemic stroke (AIS) vary according to clinical profile and management approaches, we aimed to determine disparities in clinical outcomes between Asian and non-Asian participants of the international, Enhanced Control of Hypertension and Thrombolysis Stroke study (ENCHANTED).

Methods: ENCHANTED was a multicenter, prospective, partial-factorial, randomized, open trial of low-dose (0.6 mg/kg) versus standard-dose (0. Read More

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