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Neuropsychiatr Dis Treat 2020 23;16:1571-1581. Epub 2020 Jun 23.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi, People's Republic of China.

Purpose: To investigate differences in the functional connectivity (FC) of the primary visual cortex between patients with corneal ulcer (CU) and healthy controls (HCs) using resting-state functional magnetic resonance imaging.

Patients And Methods: A total of 30 patients with CU and 30 HCs were closely matched in terms of sex, age, and level of education. Two-sample -test, receiver operating characteristic curve, and Pearson's correlation coefficient analyses were used to determine the differences in FC between the two groups, the mean FC value of patients with CU and HCs, and the correlation between FC signal values and clinical manifestations in different brain regions of patients. Read More

J Ocul Pharmacol Ther 2020 Jun 29. Epub 2020 Jun 29.

Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, USA.

The purpose of this study was to report the clinical etiologies, microbial spectrum, antibiotic resistance, and visual acuity (VA) outcomes associated with acute endophthalmitis. A retrospective chart review of patients with International Classification of Diseases (ICD)-9 and ICD-10 codes for endophthalmitis over a 6-year period (2011-2016) at a tertiary referral center was performed. The clinical records were reviewed to evaluate clinical etiologies, microbial spectrum, antibiotic susceptibilities and resistance, and visual outcomes. Read More

BMC Ophthalmol 2020 Jun 29;20(1):256. Epub 2020 Jun 29.

Department of Ophthalmfology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Tianjin, 300052, China.

Background: To describe the clinical characteristics and analyze the predictive factors associated with improved visual acuity of 359 patients with infectious endophthalmitis.

Methods: This study retrospectively analyzed 359 eyes of 359 patients with infectious endophthalmitis from January 2014 to December 2018. The findings summarized some epidemiological characteristics of these patients, including age, sex, occupation, patient visit time, etiology, causative organisms, therapy, and best-corrected visual acuity. Read More

Br J Ophthalmol 2020 Jun 27. Epub 2020 Jun 27.

Recordati Rare Diseases, Puteaux, Puteaux, France.

Background/aims: Cystinosis is a rare, autosomal recessive disorder causing defective transport of cystine out of lysosomes. Cystadrops (0.55% cysteamine hydrochloride in viscous solution) has been used on a named-patient basis to treat the accumulation of cystine crystals in the cornea in patients with cystinosis. Read More

Clin Neurol Neurosurg 2020 Jun 17;196:106025. Epub 2020 Jun 17.

Department of Pain Clinic, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China. Electronic address:

Objectives: To compare the advantages and disadvantages of V2 + V3 idiopathic trigeminal neuralgia using peripheral nerve radiofrequency (RF) thermocoagulation (PRF) via the foramen rotundum (FR) and foramen ovale (FO) with those of semilunar ganglion RF thermocoagulation (GRF) under local anesthesia, for exploring a new and available surgical method for patients with V2 + V3 idiopathic trigeminal neuralgia.

Patients And Methods: 102 patients with V2 + V3 idiopathic trigeminal neuralgia were enrolled in this prospective randomized controlled clinical trial, and they were divided into the PRF and GRF group randomly (n = 51 in both groups). The outcome of pain relief was assessed using the Barrow Neurological Institute (BNI) pain score, and grouped as good (BNI Class I or II, no medication required) and bad (BNI Class III-V, medication required or failed). Read More

Indian J Ophthalmol 2020 Jul;68(7):1461-1463

Division of Laboratory Services, Aravind Eye Hospital and Post-Graduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.

Fungal infections are a significantly increasing cause of ocular and systemic morbidity; the vast majority of cases being ascribed to a handful of species. Fungal keratitis, unlike systemic infections, usually occur in immunocompetent individuals. Rarely, systemic infections can be associated with ocular involvement (e. Read More

Clin Ophthalmol 2020 26;14:1437-1443. Epub 2020 May 26.

Ocular Surface Center and TissueTech Inc, Miami, FL, USA.

Purpose: To evaluate the clinical outcomes of self-retained cryopreserved amniotic membrane (cAM) for the treatment of corneal ulcers.

Methods: This was a single-center, retrospective review of consecutive patients with non-healing corneal ulcers that underwent treatment with self-retained cAM (PROKERA Slim). The primary outcome measure was time to complete corneal epithelialization. Read More

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, EH16 4TJ, UK. Electronic address:

Purpose: To explore the use of optical SmartProbes for the rapid evaluation of corneal scrapes from patients with suspected microbial keratitis, as a clinical alternative to Gram stain.

Design: Experimental study with evaluation of a diagnostic technology.

Methods: Corneal scrapes were collected from 267 patients presenting with microbial keratitis at a referral cornea clinic in South India. Read More

Eye Contact Lens 2020 Jun 15. Epub 2020 Jun 15.

Department of Ophthalmology and Vision Science, UC Davis Eye Center, University of California, Davis, Sacramento, CA.

Introduction: Patients with ocular complaints frequently present to emergency departments (EDs) for care. Emergency department practitioners are often the first to evaluate these patients and determine the next steps in their care, which can be a challenging task. The purpose of this study is to determine the frequency of anterior segment pathology in the setting of the ED in hopes that this information will be useful in creating more effective management algorithms. Read More

J Fr Ophtalmol 2020 Jun 18. Epub 2020 Jun 18.

Service d'ophtalmologie, centre hospitalo-universitaire de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.

Arch Soc Esp Oftalmol 2020 Jun 17. Epub 2020 Jun 17.

Unidad de Superficie e inflamación ocular, Departamento de Oftalmología, Hospital Clínico San Carlos, Madrid, España.

Purpose: Neurotrophic corneal ulcers are difficult to treat, and the conventional treatment often results in failure. A new matrix regenerating agent ("ReGeneraTing Agents"), Cacicol® (Laboratoires Théa), has demonstrated good results over the last few years. Therefore, the aim of this study was to evaluate the response to Cacicol® in a series of cases with neurotrophic corneal ulcers. Read More

Am J Ophthalmol Case Rep 2020 Sep 2;19:100765. Epub 2020 Jun 2.

Gavin Herbert Eye Institute, University of California, Irvine, 92697, United States.

Purpose: To report a case of conjunctivitis due to Mycobacterium abscessus in the setting of keratoconjunctivitis sicca due to Sjögren's syndrome in the absence of other known risk factors such as surgery, trauma or immunosuppressive therapy.

Observations: A 61-year-old woman with a history of keratoconjunctivitis sicca secondary to Sjögren's syndrome presented with dryness, irritation, redness, and discharge in her left eye for 2 months. She was diagnosed with chronic conjunctivitis and began a regimen of moxifloxacin and an ocular ointment of dexamethasone, neomycin, and polymyxin with no improvement of symptoms. Read More

J Med Case Rep 2020 Jun 17;14(1):70. Epub 2020 Jun 17.

Ophthalmology, University of the West of Santa Catarina (Universidade do Oeste de Santa Catarina-UNOESC), Joaçaba, SC, Brazil.

Background: Ocular allergy is a common disease, especially in the pediatric population, with unpleasant and long-term consequences, including corneal complications and decreased visual acuity. This study reports two cases of corneal shield ulcer due to vernal keratoconjunctivitis, with good results of surgical debridement performed after failure of long-term clinical treatment. Furthermore, this study highlights that this therapeutic approach, although less common, is efficient in treating refractory cases that cause suffering in pediatric patients. Read More

Invest Ophthalmol Vis Sci 2020 Jun;61(6):35

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Purpose: Corneal ulcers are a common eye inflammatory disease that can cause visual impairment or even blindness if not treated promptly. Ocular trauma is a major risk factor for corneal ulcers, and corneal trauma in agricultural work can rapidly progress to corneal ulcers. This study aims to evaluate the changes in the ocular surface (OS) microbiome of patients with traumatic corneal ulcer (TCU). Read More

Front Immunol 2020 27;11:942. Epub 2020 May 27.

Banc de Sang i Teixits, Barcelona, Spain.

Cord blood platelet rich plasma (CB-PRP) derivatives have been investigated as potential therapeutic agents for the treatment of diverse conditions including ocular surface disease and skin ulcers. We have developed processes for the formulation of several CB-PRP preparations, which have different composition and attributes. Here we describe the molecular characteristics of these preparations and we make recommendations as to their most appropriate clinical application based on functional and immunomodulatory profiles. Read More

J Biol Regul Homeost Agents 2020 Mar-Apr;34(2):593-598

Department of Ophthalmology, Jinan second People's Hospital, Jinan, Shandong, China.

Vet Ophthalmol 2020 Jun 8. Epub 2020 Jun 8.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Objective: To describe the complications and determine the visual outcomes associated with phacoemulsification surgery in alpacas.

Animals: Five alpacas (nine operated eyes).

Procedures: Medical records of alpacas with a clinical diagnosis of cataracts that received elective phacoemulsification surgery at Cornell University over a 15 year period were reviewed. Read More

Acta Ophthalmol 2020 Jun 1. Epub 2020 Jun 1.

Shimane University, Matsue, Japan.

Acta Vet Scand 2020 May 26;62(1):23. Epub 2020 May 26.

Department of Agrarian and Environmental Sciences, Santa Cruz State University, Rodovia Jorge Amado, Ilheus, Bahia, 45662-900, Brazil.

Background: The tear film is a trilaminar fluid composed mainly of lipids, electrolytes, proteins and water. It is responsible for lubrication, nutrition and protection against microbial and toxic agents. Disruption of any these components may weaken the ocular surface, making it more susceptible to disease. Read More

Zhonghua Yan Ke Za Zhi 2020 May;56(5):370-375

Qingdao Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China.

To analyze the clinical characteristics and treatment of ocular injury caused by chestnut burr. Retrospective case series study. Data of 48 patients (48 eyes) with ocular injuries caused by chestnut burrs hospitalized in Qingdao Eye Hospital were collected from January 2013 to March 2019. Read More

Eye Contact Lens 2020 May 14. Epub 2020 May 14.

Division of Clinical Neuroscience (D.S.J.T.), Academic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Ophthalmology (D.S.J.T.), Queen's Medical Centre, Nottingham, United Kingdom; Departments of Ophthalmology (D.S.J.T., M.M., S.N.S., T.P.), and Microbiology (J.M.), James Cook University Hospital, Middlesbrough, United Kingdom; and National Specialist Ophthalmic Pathology Service (H.S.M.), Royal Hallamshire Hospital, Sheffield, United Kingdom.

Objectives: To report the first case of Arthrographis kalrae keratitis complicated by endophthalmitis in the UK and to review the current literature.

Methods: A case report with literature review.

Results: A 65-year-old male patient, with a background of treated B-cell lymphoma and herpes simplex virus-related neurotrophic keratopathy, presented with a large infiltrative corneal ulcer in the right eye. Read More

Curr Opin Ophthalmol 2020 Jul;31(4):293-301

Royal Victorian Eye and Ear Hospital.

Purpose Of Review: The management of peripheral corneal diseases, including Mooren's ulcer, Terrien's marginal degeneration, peripheral ulcerative keratitis and pellucid marginal degeneration is challenging. Circular grafts must either be very large, resulting in the excision of healthy tissue, or eccentric, leading to high levels of astigmatism. This review summarizes the range of noncircular keratoplasty procedures available to surgeons, in addition to their indications, and surgical techniques. Read More

Ir Vet J 2020 5;73. Epub 2020 May 5.

Dubai Equine Hospital, 2 St N 22A, Dubai, United Arab Emirates.

Background: Application of an autogenous fascia lata graft in the treatment of keratomalacia in the horse has not been reported. The present case describes the use of an autologous fascia lata graft to surgically treat a complicated corneal ulcer in a horse.

Case Presentation: A 12-year-old Arabian mare was admitted to Sharjah Equine Hospital with a history of right eye ulcerative keratitis of unknown duration. Read More

Am J Ophthalmol 2020 May 5. Epub 2020 May 5.

Ophthalmic Clinic. G. d'Annunzio University of Chieti-Pescara, Italy.

Purpose: To evaluate the renewal of corneal nerves structure and function in patients with neurotrophic keratopathy (NK) treated with recombinant human Nerve Growth Factor (rhNGF) eyedrops.

Design: Prospective, interventional, before-and-after case series METHODS: This study included 18 patients with NK with a persistent epithelial defect or corneal ulcer, treated with topical rhNGF and age-matched healthy controls. Patients underwent clinical examination with corneal fluorescein staining, Schirmer 1 tear test, assessment of corneal sensitivity with the Cochet Bonnet aesthesiometer, and morphological examination of the nerves by In vivo confocal microscopy (IVCM) at baseline and at 4 and 8 weeks of treatment. Read More

Sci Rep 2020 Apr 30;10(1):7388. Epub 2020 Apr 30.

Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan.

This nationwide, retrospective, matched cohort study was designed to investigate the risk of corneal ulcer in patients with diabetes mellitus (DM). It included 238,701 patients with DM, recruited between 2003 and 2005 from the Longitudinal Cohort of Diabetes Patients database. The control group included the same number of age- and sex-matched non-DM patients selected from the Taiwan Longitudinal Health Insurance Database, 2000. Read More

Eur J Ophthalmol 2020 Apr 28:1120672120921379. Epub 2020 Apr 28.

Hôpital des Quinze-Vingts, Paris, France.

Aim: The aim of this study was to assess the efficacy and safety of corneal scrubbing associated with matrix regenerating agent on corneal wound healing in patients with persistent corneal ulcers.

Methods: This was a retrospective case study in patients with difficult-to-treat corneal ulcer. Corneal scrubbing was performed with a sterile dry cotton bud to eliminate damaged epithelial cells and corneal deposits, promoting epithelial renewal. Read More

Cornea 2020 Mar 19. Epub 2020 Mar 19.

Department of Ophthalmology, University of Münster Medical Center, Münster, Germany.

Purpose: To present the results of a modified surgical technique for secure tightening and fixation of multilayer amniotic membranes (AMs) in sterile deep or perforating corneal ulcers.

Methods: We retrospectively analyzed the data of patients suffering from corneal ulcers who had been treated between February 2016 and June 2018 with running and resorbable sutures to fixate multilayer AMs. The parameters analyzed were gender, age, etiology of corneal ulcer, ulcer diameter, corneal thickness (CST) before and after the microsurgical procedure as measured with optical coherence tomography, number of inlays, repeat surgical procedures, follow-up duration in months, and rate of success (defined as a stable anterior chamber with improved CST, a negative Seidel test, and no need for any microsurgical keratoplasty during the first 6 months after treatment). Read More

Curr Pharm Des 2020 Apr 24. Epub 2020 Apr 24.

Departments of Pharmacology and Pathology, School of Medicine, University of Zagreb, Salata 11, POB 916, 10000 Zagreb. Croatia.

This review is focused on the healing of fistulas and stable gastric pentadecapeptide BPC 157. Assuming that the healing of the various wounds is essential also for the gastrointestinal fistulas healing, the healing effect on fistulas in rats, consistently noted with the stable gastric pentadecapeptide BPC 157, may raise several interesting possibilities. BPC 157 is originally an anti-ulcer agent, native to and stable in human gastric juice (for more than 24 h). Read More

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):270-272

Department of Microbiology, TNMC and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.

Basidiobolus ranarum is an uncommon pathogen in ocular infections. It has been previously reported from subcutaneous and gastrointestinal infections. Here, we report a rare case of ocular infection caused by B. Read More

Indian J Ophthalmol 2020 May;68(5):922-924

Department of Uvea, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India.

This case report represents an unusual presentation of Mycobacterium tuberculosis-associated corneal ulcer with hypopyon. A 64-year-old man presented with a hypopyon corneal ulcer in the right eye. His corneal scrapings were negative, and the ulcer was not responding to empirical antimicrobial therapy. Read More

Taiwan J Ophthalmol 2020 Jan-Mar;10(1):13-21. Epub 2020 Mar 4.

R&D Department, TissueTech Inc., Miami, FL, USA.

Neurotrophic keratitis (NK), a degenerative disease caused by damage to the trigeminal nerve, abolishes both tearing and blinking reflexes, thus causing the most severe forms of dry eye disease (DED). Conversely, the increasing severity of DED also leads to progressive loss of corneal nerve density, potentially resulting in NK. Both diseases manifest the same spectrum of corneal pathologies including inflammation and corneal epithelial keratitis, which can progress into vision-threatening epithelial defect and stromal ulceration. Read More

J Ophthalmic Vis Res 2020 Apr-Jun;15(2):128-137. Epub 2020 Apr 6.

Department of Ophthalmology, Long School of Medicine, University of Texas Health at San Antonio, San Antonio, Texas, USA.

Purpose: To determine the causative organisms and associated risk factors for infectious keratitis in South Texas.

Methods: This retrospective study was performed at a tertiary teaching hospital system in South Texas. Medical records of all patients who presented with infectious keratitis from 2012 to 2018 were reviewed. Read More

Zhonghua Yan Ke Za Zhi 2020 Apr;56(4):294-298

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China.

To investigate the clinical characteristics and therapeutic effect of neurotrophic keratitis (NK). A retrospective case series study. A total of 46 patients (48 eyes) with clinically diagnosed NK in Beijing Tongren Hospital from May 2013 to July 2016 were analyzed, including 26 males (26 eyes) and 20 females (22 eyes), aged (51±18) years. Read More

Zhonghua Yan Ke Za Zhi 2020 Apr;56(4):286-293

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China.

To discuss clinical features and treatments of fungal keratitis, and to provide statistical data for clinical therapy and increase the therapeutic effects. This is a retrospective case series study. An analysis was performed by collecting patients' demography features, risk factors, onset time, lab results, clinical features and treatment from 1 414 cases of fungal keratitis from January 2006 to October 2016 in Qingdao Eye Hospital, Shandong Eye Institute. Read More

Am J Ophthalmol Case Rep 2020 Jun 9;18:100648. Epub 2020 Mar 9.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Purpose: To describe four cases of concomitant herpes simplex keratitis (HSK) and autoimmune-associated ulcerative keratitis (UK) in patients with rheumatoid arthritis (RA).

Observations: All patients developed HSK and UK while undergoing treatment for RA. The average age of onset for RA, UK and HSK was 49. Read More

Clin Case Rep 2020 Apr 26;8(4):709-715. Epub 2020 Feb 26.

Ophthalmology Section Equine Department Vetsuisse Faculty University of Zurich Zurich Switzerland.

Corneal cross-linking should be considered as treatment option in Friesian horses with infectious keratitis and corneal dystrophy. Optical coherence tomography, giving information of corneal structure, can help for diagnosis and monitoring. Read More

J Refract Surg 2020 Apr;36(4):258-264

Purpose: To compare the outcomes of accelerated photoactivated chromophore for keratitis corneal cross-linking (PACK-CXL) as an adjunct treatment for bacterial keratitis (PACK-CXL plus standard antibiotic therapy) for patients receiving only standard antibiotic therapy.

Methods: Retrospective cohort study of outcomes of patients with moderate infectious presumed bacterial keratitis (ulcer diameter 2 to 7 mm and stromal depth < 300 µm) were compared before and after initiation of a new treatment protocol of PACK-CXL in addition to standard antibiotic treatment.

Results: A total of 70 eyes of 70 patients were included: 39 eyes in the PACK-CXL plus antibiotic (PACK-ABX) group and 31 eyes in the antibiotic only (ABX) control group. Read More

Ann Clin Microbiol Antimicrob 2020 Mar 30;19(1):11. Epub 2020 Mar 30.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City, Taiwan.

Background: Fungal keratitis (FK) has been shown to be a climate-sensitive disease. The differentiation between FK from bacterial keratitis (BK) was difficult. The purpose of this study was to compare the bacteriology and mycology between tropical and subtropical Taiwan and to investigate the independent risk factors for identification of fungi from bacteria. Read More

Saudi J Biol Sci 2020 Feb 26;27(2):751-756. Epub 2019 Dec 26.

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia.

Fungal keratitis caused by the species of is a common and leading problem in developing countries like India. In this study, a total of 135 isolates from keratitis were studied by sequence analyses of the internal transcribed spacer (ITS) region performed by nucleotide-nucleotide BLAST analysis followed by the initial identification of the isolates based on conidial and colony morphology. The sequence analysis revealed several unusual species which were never reported in eye infections such as , , , . Read More

Saudi J Biol Sci 2020 Feb 27;27(2):701-705. Epub 2019 Nov 27.

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia.

Mycotic/fungal keratitis is a suppurative, generally ulcerative infection of the cornea. The filamentous fungi, spp. are the second leading cause of mycotic keratitis, particularly in India. Read More

Biomed Res Int 2020 28;2020:7403842. Epub 2020 Feb 28.

Aier Eye Hospital of Wuhan University, Wuhan, Hubei 430063, China.

Purpose: To evaluate the clinical and in vivo confocal microscopy outcome of lamellar keratoplasty combined with amniotic membrane transplantation for the treatment of corneal perforations.

Methods: In this retrospective, noncomparative, and interventional case series, 13 eyes of 13 patients with corneal perforation were included. All eyes were treated with lamellar keratoplasty combined with amniotic membrane transplantation for corneal reconstruction. Read More

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):243-245. Epub 2020 Jan 29.

Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Natural honey in spite of its usefulness is known to contain certain microorganisms. In the present study, we describe a case of after using topical honey administered by a traditional medicine therapist. A 32-year-old male came with red eye and blurred vision. Read More

Ophthalmol Retina 2020 06 13;4(6):560-567. Epub 2020 Jan 13.

Wilmer Eye Institute, The Johns Hopkins Hospital, Baltimore, Maryland. Electronic address:

Purpose: To assess how ocular ultrasound findings correlate with clinical parameters of patients with infectious keratitis and concern for endophthalmitis and to evaluate the usefulness of ultrasound in managing these patients.

Design: Retrospective study.

Participants: Seventy-three eyes of 73 patients with microbial keratitis who underwent ultrasound to evaluate for endophthalmitis were included. Read More

Eur J Ophthalmol 2020 Mar 6:1120672120909768. Epub 2020 Mar 6.

Centro de Oftalmología Barraquer, Barcelona, Spain.

Introduction: Mooren's ulcer is a painful, inflammatory chronic keratitis that affects corneal periphery, progressing centripetally, ultimately ending in perforation. The first line of treatment includes systemic immunomodulators, with surgery being the last option. We present a case of bilateral Boston keratoprosthesis implantation for severe Mooren's ulcer that responded differently in each eye. Read More

Am J Ophthalmol Case Rep 2020 Jun 24;18:100630. Epub 2020 Feb 24.

Department of Ophthalmology, Icahn School of Medicine Mount Sinai Hospital, 1468 Madison Ave, New York, NY, 10029, USA.

Purpose: To present a unique case of keratitis with progression to corneal perforation and endophthalmitis, in the setting of epidermal growth factor receptor inhibitor (erlotinib) therapy for advanced non-small cell lung cancer.

Observations: An 89-year-old female with non-small cell lung cancer on erlotinib presented with corneal perforation due to infectious keratitis. Microbial cultures grew a virulent pathogen known to affect immunocompromised patients that has not been previously described to cause infectious keratitis. Read More

Surv Ophthalmol 2020 Sep - Oct;65(5):513-529. Epub 2020 Feb 22.

Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. Electronic address:

Ocular complications from diabetes mellitus are common. Diabetic keratopathy, the most frequent clinical condition affecting the human cornea, is a potentially sight-threatening condition caused mostly by epithelial disturbances that are of clinical and research attention because of their severity. Diabetic keratopathy exhibits several clinical manifestations, including persistent corneal epithelial erosion, superficial punctate keratopathy, delayed epithelial regeneration, and decreased corneal sensitivity, that may lead to compromised visual acuity or permanent vision loss. Read More

Am J Ophthalmol Case Rep 2020 Mar 31;17:100616. Epub 2020 Jan 31.

Department of Ophthalmology, Truhlsen Eye Institute at the University of Nebraska Medical Center, 3902 Leavenworth St, Omaha, NE, 68105, USA.

Purpose: To report a case of fungal keratitis after corneal collagen crosslinking (CXL) surgery.

Observations: We report a case of fungal keratitis after CXL for post-refractive surgery ectasia. The patient presented 12 days after surgery with a corneal ulcer that was culture positive for species of fungus. Read More

Curr Drug Discov Technol 2020 Feb 13. Epub 2020 Feb 13.

Poostchi Eye Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz. Iran.

Aim: The aim of this study was to evaluate the efficacy of honey-based ophthalmic drop in patients with foreign body induced corneal ulcer.

Background: Honey is traditionally used for the skin, mucosal and corneal ulcers. Its use is well studied in human skin and mucosal ulcers and animal model of corneal ulcer with promising effects. Read More

BMC Rheumatol 2020 7;4. Epub 2020 Feb 7.

Department of Rheumatology A, El Ayachi Hospital-Salé, CHU Ibn Sina, University Mohammed V-, Rabat, Morocco.

Background: Peripheral ulcerative keratitis (PUK) is a severe inflammatory ocular disease that can affect patients with a long history of rheumatoid arthritis (RA). The use of biotherapy has revolutionized the treatment of the RA and has provided encouraging outcomes especially in the treatment of PUK reported in few cases. In this article, we describe the case of two patients with the history of perforated corneal ulcer complicating RA treated successfully by biologic agents. Read More