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Vet Ophthalmol 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Objective: Compare CXL treatment with medical treatment alone in horses with stromal, ulcerative keratitis.

Animals Studied: 24 horses (24 eyes) with stromal, ulcerative keratitis were included.

Procedure: 12 horses were initially treated with CXL, and 12 horses were given conventional medical treatment. Read More

Ethiop J Health Sci 2019 Mar;29(2):291-294

Jimma University, Department of Ophthalmology, Ethiopia.

Background: Intra-orbital hematoma is an eye disease that is usually attributed to trauma, neoplasm, acute sinusitis or vascular malformations. However, spontaneous hematoma is a rare condition and can be an early manifestation of hematological disorders.

Case Report: This is a case report on a 2-days old male neonate presented with proptosis of the right eye since the second day of birth. Read More

Medicine (Baltimore) 2019 Apr;98(16):e14964

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo 173-8605.

Recurrent corneal erosion (RCE) is a common disorder causing ocular pain, tearing, photophobia, and visual impairments. Various factors such as ocular trauma, ocular surgery, corneal dystrophy, contact lens wear, and diabetes mellitus (DM) can cause RCE. The purpose of this study was to determine the causative factors and clinical course of RCE. Read More

PLoS One 2019 18;14(4):e0215727. Epub 2019 Apr 18.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC-SSB3, Los Angeles, CA, United States of America.

Complex interactions between HSV-1 and infiltrating immune cells play important roles in establishing localized, acute virus replication as well as chronic latent infection. The extent and duration of initial virus replication are the key determinants of subsequent pathologic inflammatory responses and therefore, the accumulation of immune cell populations at this time point is a key target for prevention. Therefore, we evaluated the role of various immune cell infiltrates between 1 h and 28 days post-infection (PI) using mice infected with virulent HSV-1 strain McKrae without corneal scarification. Read More

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To evaluate the microbiological profile and outcome in cases with infective keratitis in Stevens-Johnson syndrome (SJS).

Methods: Eighty-three eyes of 68 patients with SJS presenting with microbial keratitis were recruited and managed with standard antimicrobial therapy.

Results: Microbial keratitis developed in 34% of patients with SJS (83 eyes, 68 patients) over a period of 5 years. Read More

Hautarzt 2019 Apr 17. Epub 2019 Apr 17.

Klinik für Augenheilkunde, Universitätsklinikum des Saarlandes, Homburg/Saar, Deutschland.

Numerous systemic diseases can be manifested at the cornea. Sometimes the corneal involvement is the first sign of the systemic process. It may be manifested in many different forms, such as an ulcer in the corneal periphery or a crystalline keratopathy. Read More

Eye Contact Lens 2019 Apr 9. Epub 2019 Apr 9.

Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA.

Purpose: To report a patient with chronic ocular graft versus host disease who achieved long-term stability of a descemetocele using prosthetic replacement of the ocular surface ecosystem (PROSE) treatment.

Methods: Case report and literature review.

Results: A 60-year-old white man, who underwent PROSE treatment 4 years earlier to address severe dry eyes secondary to ocular graft versus host disease, developed a central corneal ulcer that resulted in descemetocele formation. Read More

Int Ophthalmol 2019 Apr 13. Epub 2019 Apr 13.

Division of Ophthalmology, Sourasky Medical Center Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To report and characterize cases of very late onset (5 years or more after surgery) flap margin corneal ulcers after laser in situ keratomileusis (LASIK) procedure.

Methods: A retrospective case series of consecutive patients who were diagnosed with very late flap margin corneal ulcers following LASIK, between January 2014 and July 2017. All patients were treated with topical antibiotics and were followed up until complete resolution. Read More

BMC Ophthalmol 2019 Apr 2;19(1):85. Epub 2019 Apr 2.

Department of Ophthalmology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, 200065, China.

Purpose: To report a surgical technique and the surgical outcomes of individualized penetrating keratoplasty (PK) using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers.

Methods: Fourteen perforated eyes from 14 patients who underwent individualized PK using edge-trimmed glycerol-preserved donor corneas, were included in the retrospective study. The perforations were mainly 1-2 mm in size except for one that was 2. Read More

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(1):16-21

Ophthalmic Research Center, Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The aim of this study was to describe patient demographics, microbiological profile, and antibiotic susceptibility of corneal ulcer at a tertiary referral center to improve and optimize diagnosis and treatment of this potentially blinding entity and to reduce antibiotic misuse. Detailed external and slit-lamp bio-microscopic examination of 123 consecutive patients with suspected corneal ulcer was performed at an ophthalmology clinic. Corneal scraping was carried out under slit-lamp bio-microscopy. Read More

Am J Ophthalmol 2019 Mar 19. Epub 2019 Mar 19.

Department of Ophthalmology; Francis I. Proctor Foundation. Electronic address:

Purpose: To compare longitudinal visual acuity outcomes of fungal corneal ulcers with those of bacterial ulcers.

Design: Prospective cohort study SETTING: Tertiary eye hospital in South India STUDY POPULATION: 100 individuals who had been diagnosed four years prior with either fungal or bacterial keratitis and had been enrolled in one of two concurrent randomized trials, out of 152 consecutive participants eligible for the study.

Exposure: Causative organism of infectious keratitis (bacteria versus fungus) MAIN OUTCOME MEASURES: Presenting visual acuity, best spectacle corrected visual acuity (BSCVA), and hard contact lens-corrected visual acuity (CLVA). Read More

Indian J Med Microbiol 2018 Oct-Dec;36(4):594-596

Department of Ocular Microbiology, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.

We report a case of keratitis caused by a rare fungus Podospora austroamericana. Clinical and microbiological evaluation of the corneal ulcer was done and the treatment outcome was studied. The fungus was grown from the corneal scraping, and it was identified as P. Read More

JAMA Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago.

Clin Optom (Auckl) 2019 13;11:11-14. Epub 2019 Feb 13.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran,

Microbial keratitis is a potentially blinding condition for those who do not receive rapid and proper treatment. The case of a healthy 26-year-old man who has worn extended-wear hydrogel soft contact lenses and developed a unilateral central corneal ulcer with underlying dense stromal infiltrates surrounded by subepithelial and superficial stromal opacity in a reticular pattern along with several complications is reported. Read More

J Fr Ophtalmol 2019 Apr 8;42(4):e177-e179. Epub 2019 Mar 8.

Mohammed V University Souissi, Faculty of Medicine, department "A" of ophthalmology, Specialties hospital, Rabat, Morocco.

GMS Ophthalmol Cases 2019 12;9:Doc03. Epub 2019 Feb 12.

Department of Ophthalmology, University Hospital Regensburg, Germany.

spp. are leading fungal pathogenes in contact lens associated keratitis and may evoke endophthalmitis. Since spp. Read More

Yakugaku Zasshi 2019 ;139(3):385-391

Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.

Sacran, a new polysaccharide isolated from cyanobacterium Aphanothece sacrum (Sur.) Okada, is known to have potential as an active pharmaceutical ingredient (API) for the treatment of atopic dermatitis, various types of dermatitis, skin wound, hemorrhoids and corneal epithelium disorder. In the present studies, the effects of sacran on skin injury and skin pain induced by stratum corneum tape-stripping and gastric ulcer induced by indomethacin, a non-steroidal anti-inflammatory drug (NSAID), and hydrochloride/ethanol (HCl/EtOH) in mice were investigated. Read More

Am J Ophthalmol Case Rep 2019 Jun 7;14:26-27. Epub 2019 Feb 7.

Parker Cornea, 1720 University Blvd Suite 503, Birmingham, AL, 35233, USA.

Purpose: To describe a case of corneal ulceration associated with Nivolumab use.

Observations: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies - including surgery to cover the ulcer with a conjunctival flap - until topical prednisolone acetate was tried, which was curative.

Conclusions And Importance: Nivolumab use may be associated with a form of steroid-responsive corneal ulceration. Read More

Int J Ophthalmol 2019 18;12(2):194-200. Epub 2019 Feb 18.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, China.

Aim: To investigate the ocular surface microbiome profile of patients with fungal keratitis (FK) through bacterial 16S rDNA sequencing.

Methods: The swab samples were collected from 8 patients with FK (Group 1 from the corneal ulcer, Group 2 from the conjunctival sac of the infected eyes, and Group 3 from the conjunctival sac of the fellow eyes) and 10 healthy eyes (Group 4 from the conjunctival sac). Bacterial 16S rDNA V4-V5 region sequencing was performed to characterize the bacterial communities on the ocular surfaces of the patients with FK. Read More

Microb Drug Resist 2019 Feb 26. Epub 2019 Feb 26.

1 Department of Ocular Microbiology and Aravind Medical Research Foundation, Madurai, India.

Global emergence of multidrug resistant (MDR) strains limits therapeutic efficacy in Pseudomonas aeruginosa corneal ulcers. Identifying the primary causal factors of resistance shall improve clinical management. In this study, we sought to identify the underlying mechanisms of fluoroquinolone and aminoglycoside resistance in MDR, non-MDR, and drug susceptible P. Read More

Biomed Res Int 2019 20;2019:6395840. Epub 2019 Jan 20.

Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, India.

Fungal aetiology of keratitis/corneal ulcer is considered to be one of the leading causes of ocular morbidity, particularly in developing countries including India. More importantly, and are reported commonly implicating corneal ulcer and against this background the present work was undertaken so as to understand the current epidemiological trend of the two fungal keratitis. During the project period, a total of 500 corneal scrapings were collected from suspected mycotic keratitis patients, of which 411 (82. Read More

Digit J Ophthalmol 2018 19;24(4):24-26. Epub 2018 Dec 19.

Albany Medical College, Albany, New York.

Background: The concentration and dosing of povidone-iodine (PI) solution used in surgical site prophylaxis are variable. Prior in vitro work has demonstrated that dilute PI solutions (<1%) had greater bactericidal activity than stock solutions (10%). Studies using pathologic clinical isolates from the eye have yielded mixed results. Read More

Clin Ophthalmol 2019 5;13:243-251. Epub 2019 Feb 5.

Smt Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad 500034, Telangana, India,

Purpose: To report the presentation and management outcomes of endophthalmitis with endoscopic vitrectomy.

Methods: This is a retrospective interventional case series conducted at a tertiary eye care center in south India. Thirty three eyes of 33 patients were included. Read More

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):127-133

Qingdao Eye Hospital, Shandong Eye Institute, Qingdao 266071, China.

To investigate the clinical features, treatment distribution and transition of Mooren's ulcer, and to observe the clinical outcomes and recurrence. Retrospective series case study. Medical records of 125 patients (154 eyes) with Mooren's ulcer treated between January 1996 and December 2015 at our hospital were retrospectively reviewed. Read More

Arq Bras Oftalmol 2019 Mar-Apr;82(2):103-106. Epub 2019 Jan 10.

Fundación Oftalmológica Los Andes, Universidad de los Andes, Santiago, Chile.

Purpose: To report our initial experience in the treatment of Acanthamoeba keratitis with accelerated corneal collagen cross-linking.

Methods: Retrospective chart review of patients diagnosed with Acanthamoeba keratitis with progressive corneal melting who were treated with accelerated collagen cross-linking.

Results: A total of 6 eyes (5 patients) were reviewed. Read More

Eye Contact Lens 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology (S.S.K., K.C.S., Y.B., A.C.-Y.L., and J.S.-M.L.), Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China; Department of Ophthalmology (T.C.-Y.C.), Hong Kong Sanatorium and Hospital, Hong Kong, China; Department of Ophthalmology (V.J.), University of Pittsburgh Medical Centre, Pittsburgh, PA; Cornea and External Eye Disease Service (L.T.), Singapore National Eye Centre, Singapore; and Ocular Surface Research Group (L.T.), Singapore Eye Research Institute, Singapore.

Objectives: To evaluate recent studies on available and experimental therapies in preventing or minimizing corneal stromal scarring after injury.

Methods: We performed an Entrez PubMed literature search using keywords "cornea," "scarring," "haze," "opacity," "ulcer," "treatments," "therapies," "treatment complications," and "pathophysiology" resulting in 390 articles of which 12 were analyzed after filtering, based on English language and publication within 8 years, and curation for relevance by the authors.

Results: The 12 articles selected included four randomized control trials (RCTs) (two were double-blinded placebo-controlled RCTs, one was a prospective partially masked RCT, and one was an open-label RCT), two retrospective observational studies, and six laboratory-based studies including two studies having in vivo and in vitro experiments, one was in vivo study, one was ex vivo study, and the last two were in vitro studies. Read More

Vet Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri.

Objectives: To serially evaluate morphologic and elemental composition changes to diamond burr tips (DBTs) comparing two sterilization protocols.

Animals Studied: A total of 300 fresh cadaver porcine globes.

Procedures: Six DBTs were randomly, equally assigned into Group 1 or 2, and then analyzed using Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS) at 0, 25, 50, and 100 cycles. Read More

Vet Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Servei d'Oftalmologia de la Fundació Hospital Clínic Veterinari, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain.

Objective: To describe the surgical technique and outcome of amniotic membrane transplantation (AMT) for treatment of complicated corneal ulcers in dogs.

Animals Studied: One hundred and eleven dogs.

Procedure: Medical records (2010-2017) were reviewed to identify canine patients that underwent AMT for the treatment of complicated corneal ulcers. Read More

Vet Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California.

Objective: (a) To evaluate the epidemiology of equine eosinophilic keratoconjunctivitis (EK) in the western United States, (b) to ascertain the efficacy of keratectomy and diamond burr debridement vs medical management alone, (c) to determine the efficacy of various medical therapies, and (d) to further characterize the histopathologic findings of the disease in horses.

Animals Studied: Twenty-nine horses (47 eyes) diagnosed with EK from 1993 to 2017.

Procedure: Retrospective medical record review; owner questionnaire. Read More

Surv Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

Statins, 3-hydroxy-3-methyl-gutaryl coenzyme A reductase inhibitors, are a class of lipid-lowering drugs with anti-inflammatory, immunomodulatory, and vascular effects. Statins are increasingly being used in the treatment of a variety of medical conditions. We examine the actions of statins on the eye and its associated ophthalmic disorders. Read More

J Coll Physicians Surg Pak 2019 Feb;29(2):133-136

Department of Medical Record, Jinan Bus Hospital, Shandong Province, 250000, China.

Objective: To observe the clinical efficacy and safety of injection therapy of amphotericin B combined with autologous serum in the treatment of fungal corneal ulcer.

Study Design: An experimental study.

Place And Duration Of Study: Department of Ophthalmology, Jinan Second People's Hospital, Shandong Province, China, from July 2013 to June 2017. Read More

J Am Vet Med Assoc 2018 Dec;253(12):1623-1629

CASE DESCRIPTION A 7-year-old sexually intact female snow leopard (Panthera uncia) was examined because of blepharospasm, periocular discharge, ventral deviation of the upper eyelid cilia, third eyelid prolapse, and corneal opacity of the right eye. CLINICAL FINDINGS An ophthalmic examination performed with the patient anesthetized revealed a 3 × 3-mm ulcer that extended approximately 60% of the depth of the right cornea and was accompanied by perilesional and intralesional cellular infiltrates and active vascularization. The upper eyelid of the right eye also had a previously repaired coloboma resulting in trichiasis. Read More

Exp Parasitol 2019 Feb 12;197:29-35. Epub 2019 Jan 12.

Faculty of Superior Studies Iztacala, UNAM. Tlalnepantla, State of Mexico, Mexico. Electronic address:

Free-living amoebae of the genus Acanthamoeba are the etiological agents of cutaneous lesions, granulomatous amoebic encephalitis (GAE) and amoebic keratitis (AK), which are chronic infections with poor prognosis if not diagnosed promptly. Currently, there is no optimal therapeutic scheme to eradicate the pathologies these protozoa cause. In this study we report the morphological and molecular identification of three species of the genus Acanthamoeba, belonging to T4 group; A. Read More

Clin Interv Aging 2019 27;14:53-63. Epub 2018 Dec 27.

Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Diabetes mellitus (DM) has been emerging as one of the most serious health problems worldwide. Ocular complications of DM are currently one of the major causes of blindness in developed countries, among which diabetic retinopathy is relatively well studied and understood. However, although ocular surface complications of DM are common, diabetic complications of anterior segment of the eye, such as, cornea, conjunctiva, and lacrimal glands, are often overlooked. Read More

J Mycol Med 2019 Apr 7;29(1):71-74. Epub 2019 Jan 7.

Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Hormographiella aspergillata, a basidiomycete is a rare cause of human infection. We report a case of 70-year-old female with corneal ulcer and endophthalmitis caused by this agent. The patient had an intraocular implantation of lens following a cataract surgery. Read More

Cornea 2019 Mar;38(3):338-343

Beirut Eye and ENT Specialist Hospital, Beirut, Lebanon.

Purpose: To report the incidence, characteristics, clinical presentations, risk factors, and the available treatment modalities of sterile peripheral ulcerative keratitis (PUK) post-corneal collagen crosslinking (CXL).

Methods: This study is a retrospective study including 771 eyes of 474 patients operated for keratoconus or ectasia after LASIK between January 2010 and June 2017 at Beirut Eye & ENT Specialist hospital. The average follow-up period was 4. Read More

Eur J Ophthalmol 2018 Dec 26:1120672118818943. Epub 2018 Dec 26.

2 University Institute for Regenerative Medicine and Oral Implantology-UIRMI, UPV/EHU-Fundación Eduardo Anitua, Vitoria, Spain.

Purpose:: To evaluate the efficacy and safety of plasma rich in growth factors eye drops for the treatment of corneal and ocular surface disorders in patients with graft versus host disease.

Methods:: This retrospective and longitudinal study included graft versus host disease patients with ocular disorders. The resolution of corneal ulcers (area and density staining) was evaluated as primary outcome. Read More

Indian J Ophthalmol 2019 Jan;67(1):150-152

Cornea and Anterior Segment Service, L. V. Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India.

A 55-year-old lady developed a corneal ring infiltrate following trauma with a wooden stick. 10% KOH mount of corneal scrapings revealed septate hyaline fungal filaments. White feathery colonies with shiny black dots grew on potato dextrose agar. Read More

Indian J Ophthalmol 2019 Jan;67(1):148-150

Department of Ophthalmology, The University of Texas Medical Branch College of Medicine, Galveston; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston; Department of Ophthalmology, Houston Methodist Eye Associates, Houston Methodist Hospital, Houston, TX; Department of Ophthalmology, Weill Cornell Medicine, New York, NY, USA.

A 75-year-old male with a right eye history of chronic dry eye syndrome, glaucoma status post tube shunt, and Fuchs dystrophy status post Descemet stripping endothelial keratoplasty followed by penetrating keratoplasty (PKP) presented with a 2.7 × 4.2 mm corneal ulcer, culture positive for Shewanella algae and Klebsiella oxytoca. Read More

Indian J Ophthalmol 2019 Jan;67(1):120-121

Department of Cornea and Refractive Services, The Eye Foundation, Post Graduate Institute of Ophthalmology, Tirupur, Tamil Nadu, India.

Indian J Ophthalmol 2019 01;67(1):47-48

Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

J Fr Ophtalmol 2019 Feb 17;42(2):159-165. Epub 2018 Dec 17.

Service d'Ophtalmologie, hôpital Morvan, CHU de Brest, 2, avenue Foch, 29609 Brest, France.

Purpose: To assess the success rate of a matrix regenerating agent (RGTA) in the treatment of chronic corneal ulcers resistant to conventional treatments.

Methods: Uncontrolled prospective observational study in patients with corneal neurotrophic ulcer (Stage 2 or 3 of the Mackie classification), unresponsive to standard medical or surgical treatments and managed with RGTA as an adjunctive treatment. Corneal ulcers were evaluated using slit-lamp examination and optical coherence tomography after 2 weeks, 1 month, 2 months and 3 months. Read More

Klin Monbl Augenheilkd 2018 Dec 19;235(12):1366-1370. Epub 2018 Dec 19.

Augenklinik, Universitätsklinik Erlangen, Erlangen.

Background: The integrity of the ocular surface and the transparency of the cornea is crucial to obtain a good visual acuity - a requirement to actively participate in both social and professional environments. The homeostasis of the ocular surface is constantly endangered by microbes and by intrinsic factors with negative influence on wound healing. Furthermore, widespread use of contact lenses obtain a risk of corneal infection even resulting in corneal perforation and loss of the eye. Read More

J Ocul Pharmacol Ther 2019 Jan/Feb;35(1):38-49. Epub 2018 Dec 18.

1 Department of Surgical and Radiological Sciences, University of California-Davis, Davis, California.

Purpose: To assess safety and tolerability of a subconjunctival penciclovir implant in cats infected with feline herpesvirus type 1 (FHV-1).

Methods: Subconjunctival blank (n = 4 cats) or penciclovir-impregnated (n = 6) silicone implants were placed bilaterally in 10 normal, FHV-1-naive cats 7-8 days before viral inoculation. Outcomes included disease score, FHV-1 serology, conjunctival viral load, Schirmer tear tests (STT), tear film break-up times (TFBUTs), conjunctival histology, goblet cell density (GCD), body weight, tear and plasma penciclovir concentration, and corneal ulcer evaluation. Read More

J Curr Ophthalmol 2018 Dec 26;30(4):315-320. Epub 2018 Apr 26.

Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Jolly Grant, Dehradun, India.

Purpose: This study aimed to evaluate the anatomical, therapeutic, and functional outcome of therapeutic penetrating keratoplasty (TPK) in terms of success and failure.

Methods: In this retrospective study 57 eyes of 57 patients were reviewed. They had undergone TPK from December 2012 to June 2017. Read More

Surv Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Vernal keratoconjunctivitis, a chronic bilateral seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases, the disease is recurrent and leads to long-term visual disabling complications such as keratoconus and limbal stem cell deficiency. The main pathogenic mechanism is immunoglobulin E mediated; however, there may be non-immunoglobulin E and certain nonspecific hypersensitivity mechanisms. Read More

Ophthalmologe 2019 Feb;116(2):120-126

Augenklinik, Ludwig-Maximilians-Universität München, Mathildenstr. 8, 80336, München, Deutschland.

Background: Neurotrophic keratopathy is characterized by corneal surface alterations, persistent corneal epithelial defects and/or corneal ulcerations associated with corneal sensory abnormalities. Due to the variable clinical picture neurotrophic keratopathy is often overlooked or diagnosed too late in the course of the disease.

Objective: Discussion of the clinical picture of neurotrophic keratopathy and recommendations for correct diagnosis. Read More

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):902-910

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.

To study the effects of ultraviolet light combined with riboflavin treatment (corneal collagen-crosslinking, CXL) on infectious control and stromal reconstruction of bacterial keratitis. Experimental Study. A Staphylococcus aureus rabbit keratitis model was established by injecting Staphylococcus aureus broth into the shallow stromal layer of the right eye cornea of New Zealand white rabbits. Read More

Am J Ophthalmol Case Rep 2019 Mar 4;13:16-19. Epub 2018 Nov 4.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Purpose: Chromosome 22q11.2 micro-duplication syndrome (MDS), is a rare autosomal dominant condition, with a highly variable phenotype that ranges from unremarkable and asymptomatic, to fatal due to cardiovascular defects. Hypertelorism, downslanting palpebral fissures, superior displacement of the eyebrows, and ptosis are the most commonly reported ocular manifestations. Read More