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Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: To report a 10-year follow-up case of the first lamellar keratoplasty treatment with acellular porcine corneal stroma (APCS).

Methods: A 62-year-old woman was diagnosed with a fungal corneal ulcer and received lamellar keratoplasty treatment with APCS in 2010. The 10-year follow-up results were evaluated by slit lamp biomicroscopy, anterior segment optical coherence tomography, in vivo confocal microscopy, and corneal biomechanics analysis. Read More

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):447-453

Qingdao Eye Hospital, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China.

To developed an image analysis system of anterior segment optical coherence tomography (AS-OCT) examination results based on deep learning technology, and to evaluate its effect in identifying various types of corneal pathologies and quantified indices. A total of 4 026 patients (5 617 eyes), including 1 977 males and 2 049 females, aged (45±23) years, were enrolled in Qingdao Eye Hospital from January 2011 to August 2019. The AS-OCT images were used as a training dataset, which were labeled with location information of 16 corneal pathologies (including corneal epithelial defect, corneal epithelial thickening, corneal thinning and so on) by clinical experts, as well as the tissue stratification of the corneal epithelium and stroma. Read More

Vet Ophthalmol 2021 Jun 4. Epub 2021 Jun 4.

Department of Veterinary Science, University of Pisa, Pisa, Italy.

Objectives: To report the surgical technique and postoperative outcome of corneal repair with autologous buccal mucous membrane grafts in dogs and cats with descemetoceles, deep corneal ulcers, and perforated corneal ulcers with or without iris prolapse.

Animal Studied: Twelve cats (13 eyes) and fourteen dogs (14 eyes) were treated.

Procedures: Grafts were harvested from the unpigmented superior labial mucosa using a biopsy punch. Read More

Vet Ophthalmol 2021 Jun 2. Epub 2021 Jun 2.

Shilkin Center for Veterinary Ophthalmology, Moscow, Russia.

Objective: To compare the efficacy of dehydrated and cryopreserved heterologous corneal grafts in the management of full-thickness corneal defects in cats and dogs.

Animals Studied: Sixty-five cats (81 eyes) and 42 dogs (51 eyes) with full-thickness corneal defects of different origin.

Materials And Methods: This prospective randomized trial included 132 animal eyes (81 feline and 51 canine) with different full-thickness corneal defects. Read More

Case Rep Ophthalmol Med 2021 11;2021:5527775. Epub 2021 May 11.

Department of Ophthalmology, West Virginia University School of Medicine, WVU Eye Institute, 1 Medical Center Dr., Morgantown, WV 26506, USA.

A 72-year-old male with history of monocular vision with complete vision loss in his right eye from previous retinal detachment presented with 20/200 vision in the left eye with a corneal ulcer. Culture was obtained, and the patient was started on fortified tobramycin, fortified vancomycin, and amphotericin. Despite the antibiotics, the patient did not significantly improve, after which another culture was obtained before the patient was taken to the surgery for cryotherapy and a partial conjunctival flap. Read More

Exp Ther Med 2021 Jul 21;22(1):786. Epub 2021 May 21.

Department of Dermatology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China.

The present study aimed to evaluate the efficacy of modified corneal cross-linking (CXL) for the treatment of fungal corneal ulcers compared with that following intrastromal voriconazole injection. In total, 31 patients with fungal corneal ulcers treated at The General Hospital of Northern Theater Command between October 2017 and October 2019 were enrolled. Among them, 10 eyes were treated with ultraviolet A (UV-A)/riboflavin CXL (CXL group), whilst 21 eyes were treated with debridement combined with intrastromal voriconazole (stromal injection group). Read More

Case Rep Ophthalmol 2021 Jan-Apr;12(1):288-292. Epub 2021 Apr 30.

Ophthalmology Unit, Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy.

We describe the case of Gefitinib-related bilateral corneal perforation. An 86-year-old female patient had bilateral painless and progressive vision loss due to neurotrophic corneal ulcer, following a 2-month treatment with Gefitinib, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for metastatic adenocarcinoma of the lung with confirmed EGFR gene mutation. She had no signs of ocular infection, inflammation, or lid problems to account for the development of corneal damage. Read More

Eye Contact Lens 2021 May 25. Epub 2021 May 25.

Department of Ophthalmology (S.A., R.P.K., V.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Ophthalmology (C.P.), Stanford University School of Medicine, Stanford, CA; and The Charles T. Campbell Ophthalmic Microbiology Laboratory (S.N., R.P.K., V.J.), University of Pittsburgh Medical Center, Pittsburgh, PA.

Purpose: Serratia marcescens is a frequent ocular bacterial pathogen implicated in keratitis, endophthalmitis, and conjunctivitis. We evaluated the risk factors and treatment outcomes of ocular infections due to S. marcescens. Read More

Int Ophthalmol 2021 May 28. Epub 2021 May 28.

Jhaveri Microbiology Centre, L V Prasad Eye Institute, Hyderabad, India.

Objective: To describe the clinical features, risk factors and outcomes of Neisseria keratitis.

Methods: This is a retrospective observational study wherein medical records of cases with microbiologically proven Neisseria keratitis were reviewed. Data pertaining to the underlying predisposing factors, clinical characteristics of the corneal ulcer, antibiotic susceptibility of the Neisseria species isolate from the corneal scraping, the treatment given, and outcomes were collected and analyzed. Read More

J Infect 2021 May 24. Epub 2021 May 24.

Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Purpose: To evaluate etiology and prognostic factors for treatment outcomes of fungal keratitis (FK).

Methods: Culture-positive FK patients between 2012 and 2017 were reviewed. Treatment outcomes were categorized into success (resolved within two weeks), slow response and medication failure (no improvement or required surgery). Read More

J Intensive Care Soc 2021 May 31;22(2):136-142. Epub 2020 Mar 31.

Randomized Controlled Trial Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.

Background: High prevalence of ocular surface disorders includes eye dryness and corneal ulcer among intensive care unit patients remains an issue. This study aimed to compare the effectiveness of Lubratex ointment and vitamin A eye ointment in preventing ocular surface disorders in intensive care unit patients.

Methods: A single-center randomized clinical trial was conducted in critically ill patients of vitamin A eye ointment and Lubratex ointment in preventing ocular surface disorders. Read More

Int Med Case Rep J 2021 14;14:327-332. Epub 2021 May 14.

Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.

Infectious and traumatic corneal diseases require adequate therapy against infection and promote re-epithelialization. The appearance of multidrug-resistant bacterial strains, induced by excessive use of antibiotics in the treatment of infectious diseases, has urged researchers to study new antimicrobial formulations. Ozonated oils have demonstrated antiseptic (antibacterial, antifungal and antiviral) and reparative properties and can be proposed for the prevention and treatment of acute and chronic local infections, as an alternative to conventional topical antimicrobials. Read More

J Feline Med Surg 2021 May 14:1098612X211013021. Epub 2021 May 14.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Case Series Summary: Described are four cats diagnosed with ophthalmomyiasis externa caused by larvae. Medical records were retrospectively reviewed to identify cats with ophthalmomyiasis externa between 2005 and 2020 at Cornell University Hospital for Animals. Signalment, history, clinical and diagnostic findings, treatment and outcome were recorded. Read More

Nepal J Ophthalmol 2021 Jan;13(25):133-136

Consultant, Department of Cornea, Kedia Eye Hospital, Birgunj, Nepal.

Introduction: Acanthamoeba keratitis is a serious infection of the cornea which causes severe inflammation of the eye and loss of vision.

Case Description: A 45 years female came with a history of trauma of right eye with vegetative matter with severe pain and redness. Patient was treated with antibacterial, antifungal eye drops but the condition deteriorated. Read More

Nepal J Ophthalmol 2020 Jul;12(24):262-269

Tilganga Institute of Ophthalmology, Gaushala, Kathmandu, Nepal.

Introduction: Endophthalmitis is a serious ocular infection that can result in blindness and therefore is a major ophthalmic concern. The study was conducted to find out the microbial etiology in clinically diagnosed cases of endophthalmitis and to determine the antibacterial susceptibilities of bacterial isolates in vitro.

Materials And Methods: A retrospective analysis was carried out of all patients presenting between 15th January 2012 to 15th January 2013 with clinically diagnosed Endophthalmitis at Tilganga Institute of Ophthalmology (TIO). Read More

Case Rep Ophthalmol 2021 Jan-Apr;12(1):98-104. Epub 2021 Apr 6.

Postgraduate Education Department, Kazakh Eye Research Institute, Almaty, Kazakhstan.

Granulomatosis with polyangiitis (GPA) is a granulomatous-necrotic systemic vasculitis with a lesion of predominantly the upper and lower respiratory tracts at the onset of the disease (vasculitis, accompanied by granulomatous inflammation), and subsequently renal (glomerulonephritis). In addition, GPA may manifest as inflammation of small arteries and veins. Despite many years of study of this disease, the etiology of GPA remains unknown. Read More

JAMA 2021 05;325(18):1912

Department of Ophthalmology, University of Florida College of Medicine, Gainesville.

Am J Ophthalmol Case Rep 2021 Jun 14;22:101088. Epub 2021 Apr 14.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Purpose: The aim of this report was to describe a case of cataract surgery and Descemet stripping automated endothelial keratoplasty (DSAEK) after cytomegalovirus (CMV) corneal endotheliitis and bullous keratopathy (BK) following immunosuppressive treatment for Mooren's ulcer.

Observations: A 64-year-old man was referred to our hospital because of peripheral ulcerative keratitis in his left eye. He had a history of trabeculectomy for open angle glaucoma in his left eye. Read More

Microorganisms 2021 Apr 24;9(5). Epub 2021 Apr 24.

Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.

is known to cause severe acute endophthalmitis and often leads to poor visual outcomes in most ophthalmic infections. This retrospective study is to report the clinical settings, antimicrobial susceptibility patterns, and visual outcome of endophthalmitis at a tertiary referral institution in Taoyuan, Taiwan. endophthalmitis was diagnosed in 37 eyes of 37 patients. Read More

Ocul Surf 2021 Apr 19;21:52-57. Epub 2021 Apr 19.

Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Nashville, TN, USA. Electronic address:

Purpose: Neurotrophic keratopathy (NK) is a rare condition characterized by poor corneal sensation and healing. Cenegermin (topical recombinant nerve growth factor) has gained traction as a medical therapy for NK in recent years, and is FDA-approved for patients over two years old. However, no major trials have demonstrated the drug's efficacy in children. Read More

Eur J Pharm Sci 2021 Aug 18;163:105857. Epub 2021 Apr 18.

Ocular Pharmacology and Pharmacy Division, All India Institute of Medical Sciences, New Delhi110029, India.

The purpose of this study was to develop, characterize and evaluate novel water soluble formulation for its topical and intrastromal application. Natamycin complexed with cyclodextrin was characterized by Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The complexed powder was used to formulate 1% w/v aqueous natamycin formulation (Natasol 1%) for topical use. Read More

Eye Contact Lens 2021 Apr 16. Epub 2021 Apr 16.

Renaissance Stony Brook University School of Medicine (B.P.), Stony Brook, NY; Department of Ophthalmology (R.E., R.P.K., V.J.), University of Pittsburgh Medical Center, Pittsburgh, PA; and The Charles T Campbell Ophthalmic Microbiology Laboratory (R.P.K., V.J.), University of Pittsburgh Medical Center, Pittsburgh, PA.

Purpose: To report 7 patients (14 eyes) with bilateral Pseudomonas aeruginosa keratitis (PAK).

Methods: Case records of patients with bilateral PAK were reviewed at a single academic medical center from April 2009 to December 2020.

Results: Seven patients aged 29 to 94 years presented with bilateral P. Read More

Ophthalmologe 2021 Apr 19. Epub 2021 Apr 19.

Universitätsklinik für Augenheilkunde, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Ocul Immunol Inflamm 2021 Apr 19:1-4. Epub 2021 Apr 19.

Department of Ophthalmology, Hospital Universitari Doctor Peset, Valencia, Spain.

: To describe a case of cocaine-induced midline destructive lesions (CIMDL) associated with ocular autoimmune disease.: Observational case report.: A 45-year-old man with history of chronic osteolytic sinusitis due to cocaine abuse presented with sudden vision loss in right eye. Read More

Acta Biomater 2021 Apr 15. Epub 2021 Apr 15.

Center of Super-Diamond and Advanced Films (COSDAF) and Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong. Electronic address:

Contact lenses are widely used for visual corrections. However, while wearing contact lenses, eyes typically face discomforts (itching, irritation, burning, etc.) due to foreign object sensation, lack of oxygen permeability, and tear film disruption as opposed to a lack of wetting agents. Read More

Pan Afr Med J 2021 18;38:53. Epub 2021 Jan 18.

Service d´Ophtalmologie, Centre Hospitalier Universitaire Hassan II, Université Sidi Mohamed Ben Abdellah, Faculté de Médecine et de Pharmacie, Fès, Maroc.

Parry-Romberg´s syndrome is a rare clinical entity characterized by progressive hemifacial atrophy associated with several systemic manifestations including ophthalmologic, neurologic, maxillofacial symptoms whose treatment should be multidisciplinary. We here report a case of Parry-Romberg´s syndrome diagnosed in a patient referred for management of chronic corneal ulcer following hypoesthesia, characterized by rare and difficult-to-treat features. Read More

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, TX 78234, USA.

Introduction: American military personnel in U.S. Africa Command (AFRICOM) operate in a continent triple the size of the USA without mature medical facilities, requiring a substantial transportation network for medical evacuation. Read More

Front Vet Sci 2021 18;8:641265. Epub 2021 Mar 18.

Department of Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Corneal ulcer could be a major source of distress in small animals, with many contributing agents. In recent years, few studies evaluated the efficacy of platelet-rich plasma (PRP) in healing corneal ulcers. This study aimed to assess the ability of subconjunctival injection of autologous PRP in the treatment of corneal ulcers in dogs and cats as well as estimate the expression of matrix metalloproteinase (MMP)-2, MMP-9, and oxidative stress biomarkers in these patients. Read More

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):204-209. Epub 2021 Jan 19.

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To evaluate the effectiveness of ultraviolet (UV)-A/Riboflavin corneal cross-linking (CXL) for the treatment of the refractory cases of fungal keratitis.

Methods: In this prospective interventional study, 9 patients with the diagnosis of fungal keratitis that were referred to our emergency eye center were included. These patients were resistant to conventional treatment and underwent therapeutic UV-A/Riboflavin CXL. Read More

Vet Ophthalmol 2021 May 1;24(3):265-278. Epub 2021 Apr 1.

Davies Veterinary Specialists, Manor Farm Business Park, Hertfordshire, UK.

Objectives: To identify bacterial microorganisms associated with canine keratomalacia, review their antimicrobial sensitivity, and evaluate clinical outcomes compared to results of microbial culture.

Methods: Retrospective analysis of clinical records of dogs diagnosed with a melting corneal ulcer presented to a referral hospital in Hertfordshire, UK between 2014 and 2018.

Results: One hundred and ten melting corneal ulcers were sampled in 106 dogs. Read More