5,970 results match your criteria Corneal Ulceration and Ulcerative Keratitis


[Clinical features, treatment distribution and outcomes of Mooren's ulcer].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):127-133

Qingdao Eye Hospital, Shandong Eye Institute, Qingdao 266071, China.

To investigate the clinical features, treatment distribution and transition of Mooren's ulcer, and to observe the clinical outcomes and recurrence. Retrospective series case study. Medical records of 125 patients (154 eyes) with Mooren's ulcer treated between January 1996 and December 2015 at our hospital were retrospectively reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.011DOI Listing
February 2019

Accelerated collagen cross-linking in the management of advanced Acanthamoeba keratitis.

Arq Bras Oftalmol 2019 Mar-Apr;82(2):103-106. Epub 2019 Jan 10.

Fundación Oftalmológica Los Andes, Universidad de los Andes, Santiago, Chile.

Purpose: To report our initial experience in the treatment of Acanthamoeba keratitis with accelerated corneal collagen cross-linking.

Methods: Retrospective chart review of patients diagnosed with Acanthamoeba keratitis with progressive corneal melting who were treated with accelerated collagen cross-linking.

Results: A total of 6 eyes (5 patients) were reviewed. Read More

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http://www.gnresearch.org/doi/10.5935/0004-2749.20190018
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http://dx.doi.org/10.5935/0004-2749.20190018DOI Listing
January 2019
2 Reads

Systematic Review on Therapeutic Strategies to Minimize Corneal Stromal Scarring After Injury.

Eye Contact Lens 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology (S.S.K., K.C.S., Y.B., A.C.-Y.L., and J.S.-M.L.), Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China; Department of Ophthalmology (T.C.-Y.C.), Hong Kong Sanatorium and Hospital, Hong Kong, China; Department of Ophthalmology (V.J.), University of Pittsburgh Medical Centre, Pittsburgh, PA; Cornea and External Eye Disease Service (L.T.), Singapore National Eye Centre, Singapore; and Ocular Surface Research Group (L.T.), Singapore Eye Research Institute, Singapore.

Objectives: To evaluate recent studies on available and experimental therapies in preventing or minimizing corneal stromal scarring after injury.

Methods: We performed an Entrez PubMed literature search using keywords "cornea," "scarring," "haze," "opacity," "ulcer," "treatments," "therapies," "treatment complications," and "pathophysiology" resulting in 390 articles of which 12 were analyzed after filtering, based on English language and publication within 8 years, and curation for relevance by the authors.

Results: The 12 articles selected included four randomized control trials (RCTs) (two were double-blinded placebo-controlled RCTs, one was a prospective partially masked RCT, and one was an open-label RCT), two retrospective observational studies, and six laboratory-based studies including two studies having in vivo and in vitro experiments, one was in vivo study, one was ex vivo study, and the last two were in vitro studies. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000584DOI Listing
February 2019
5 Reads

Comparison of two cleaning and sterilization protocols of diamond burr tips used in debridement for canine superficial chronic corneal epithelial defects.

Vet Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri.

Objectives: To serially evaluate morphologic and elemental composition changes to diamond burr tips (DBTs) comparing two sterilization protocols.

Animals Studied: A total of 300 fresh cadaver porcine globes.

Procedures: Six DBTs were randomly, equally assigned into Group 1 or 2, and then analyzed using Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS) at 0, 25, 50, and 100 cycles. Read More

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http://dx.doi.org/10.1111/vop.12632DOI Listing
February 2019

A multicenter retrospective study on cryopreserved amniotic membrane transplantation for the treatment of complicated corneal ulcers in the dog.

Vet Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Servei d'Oftalmologia de la Fundació Hospital Clínic Veterinari, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain.

Objective: To describe the surgical technique and outcome of amniotic membrane transplantation (AMT) for treatment of complicated corneal ulcers in dogs.

Animals Studied: One hundred and eleven dogs.

Procedure: Medical records (2010-2017) were reviewed to identify canine patients that underwent AMT for the treatment of complicated corneal ulcers. Read More

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http://dx.doi.org/10.1111/vop.12643DOI Listing
February 2019

Equine eosinophilic keratoconjunctivitis in California: retrospective study of 47 eyes from 29 cases (1993-2017).

Vet Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California.

Objective: (a) To evaluate the epidemiology of equine eosinophilic keratoconjunctivitis (EK) in the western United States, (b) to ascertain the efficacy of keratectomy and diamond burr debridement vs medical management alone, (c) to determine the efficacy of various medical therapies, and (d) to further characterize the histopathologic findings of the disease in horses.

Animals Studied: Twenty-nine horses (47 eyes) diagnosed with EK from 1993 to 2017.

Procedure: Retrospective medical record review; owner questionnaire. Read More

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http://dx.doi.org/10.1111/vop.12621DOI Listing
January 2019

Statins in Ophthalmology.

Surv Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

3-Hydroxy-3-methyl-gutaryl coenzyme A (HMG-CoA) reductase inhibitors or 'statins' are a class of lipid lowering drugs with anti-inflammatory, immunomodulatory, and vascular effects. Statins are increasingly being used in the treatment of a variety of medical conditions. We examine the actions of statins on the eye and its associated ophthalmic disorders. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.01.013DOI Listing
January 2019
7 Reads

Efficacy and Safety of Amphotericin B with Autologous Serum for Fungal Corneal Ulcer.

J Coll Physicians Surg Pak 2019 Feb;29(2):133-136

Department of Medical Record, Jinan Bus Hospital, Shandong Province, 250000, China.

Objective: To observe the clinical efficacy and safety of injection therapy of amphotericin B combined with autologous serum in the treatment of fungal corneal ulcer.

Study Design: An experimental study.

Place And Duration Of Study: Department of Ophthalmology, Jinan Second People's Hospital, Shandong Province, China, from July 2013 to June 2017. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.02.133DOI Listing
February 2019

Use of equine amniotic membrane free-island grafts for treatment of a midstromal corneal ulcer and descemetocele in a snow leopard (Panthera uncia).

J Am Vet Med Assoc 2018 Dec;253(12):1623-1629

CASE DESCRIPTION A 7-year-old sexually intact female snow leopard (Panthera uncia) was examined because of blepharospasm, periocular discharge, ventral deviation of the upper eyelid cilia, third eyelid prolapse, and corneal opacity of the right eye. CLINICAL FINDINGS An ophthalmic examination performed with the patient anesthetized revealed a 3 × 3-mm ulcer that extended approximately 60% of the depth of the right cornea and was accompanied by perilesional and intralesional cellular infiltrates and active vascularization. The upper eyelid of the right eye also had a previously repaired coloboma resulting in trichiasis. Read More

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https://avmajournals.avma.org/doi/10.2460/javma.253.12.1623
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http://dx.doi.org/10.2460/javma.253.12.1623DOI Listing
December 2018
5 Reads

Evaluation of the sensitivity to chlorhexidine, voriconazole and itraconazole of T4 genotype Acanthamoeba isolated from Mexico.

Exp Parasitol 2019 Feb 12;197:29-35. Epub 2019 Jan 12.

Faculty of Superior Studies Iztacala, UNAM. Tlalnepantla, State of Mexico, Mexico. Electronic address:

Free-living amoebae of the genus Acanthamoeba are the etiological agents of cutaneous lesions, granulomatous amoebic encephalitis (GAE) and amoebic keratitis (AK), which are chronic infections with poor prognosis if not diagnosed promptly. Currently, there is no optimal therapeutic scheme to eradicate the pathologies these protozoa cause. In this study we report the morphological and molecular identification of three species of the genus Acanthamoeba, belonging to T4 group; A. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.01.006DOI Listing
February 2019
2 Reads
1.859 Impact Factor

Influence of diabetes mellitus on anterior segment of the eye.

Clin Interv Aging 2019 27;14:53-63. Epub 2018 Dec 27.

Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Diabetes mellitus (DM) has been emerging as one of the most serious health problems worldwide. Ocular complications of DM are currently one of the major causes of blindness in developed countries, among which diabetic retinopathy is relatively well studied and understood. However, although ocular surface complications of DM are common, diabetic complications of anterior segment of the eye, such as, cornea, conjunctiva, and lacrimal glands, are often overlooked. Read More

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https://www.dovepress.com/influence-of-diabetes-mellitus-on-
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http://dx.doi.org/10.2147/CIA.S190713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312050PMC
December 2018
8 Reads

Ocular infection caused by Hormographiella aspergillata: A case report and review of literature.

J Mycol Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Hormographiella aspergillata, a basidiomycete is a rare cause of human infection. We report a case of 70-year-old female with corneal ulcer and endophthalmitis caused by this agent. The patient had an intraocular implantation of lens following a cataract surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11565233183024
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http://dx.doi.org/10.1016/j.mycmed.2018.12.002DOI Listing
January 2019
6 Reads

Late-Onset Sterile Peripheral Ulcerative Keratitis Post-Corneal Collagen Crosslinking.

Cornea 2019 Mar;38(3):338-343

Beirut Eye and ENT Specialist Hospital, Beirut, Lebanon.

Purpose: To report the incidence, characteristics, clinical presentations, risk factors, and the available treatment modalities of sterile peripheral ulcerative keratitis (PUK) post-corneal collagen crosslinking (CXL).

Methods: This study is a retrospective study including 771 eyes of 474 patients operated for keratoconus or ectasia after LASIK between January 2010 and June 2017 at Beirut Eye & ENT Specialist hospital. The average follow-up period was 4. Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9665
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http://dx.doi.org/10.1097/ICO.0000000000001842DOI Listing
March 2019
2 Reads

Plasma rich in growth factors for the treatment of dry eye from patients with graft versus host diseases.

Eur J Ophthalmol 2018 Dec 26:1120672118818943. Epub 2018 Dec 26.

2 University Institute for Regenerative Medicine and Oral Implantology-UIRMI, UPV/EHU-Fundación Eduardo Anitua, Vitoria, Spain.

Purpose:: To evaluate the efficacy and safety of plasma rich in growth factors eye drops for the treatment of corneal and ocular surface disorders in patients with graft versus host disease.

Methods:: This retrospective and longitudinal study included graft versus host disease patients with ocular disorders. The resolution of corneal ulcers (area and density staining) was evaluated as primary outcome. Read More

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http://dx.doi.org/10.1177/1120672118818943DOI Listing
December 2018
2 Reads

Shewanella algae keratitis.

Indian J Ophthalmol 2019 Jan;67(1):148-150

Department of Ophthalmology, The University of Texas Medical Branch College of Medicine, Galveston; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston; Department of Ophthalmology, Houston Methodist Eye Associates, Houston Methodist Hospital, Houston, TX; Department of Ophthalmology, Weill Cornell Medicine, New York, NY, USA.

A 75-year-old male with a right eye history of chronic dry eye syndrome, glaucoma status post tube shunt, and Fuchs dystrophy status post Descemet stripping endothelial keratoplasty followed by penetrating keratoplasty (PKP) presented with a 2.7 × 4.2 mm corneal ulcer, culture positive for Shewanella algae and Klebsiella oxytoca. Read More

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http://dx.doi.org/10.4103/ijo.IJO_617_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324159PMC
January 2019

Healing of resistant corneal neurotrophic ulcers using a matrix regenerating agent.

J Fr Ophtalmol 2019 Feb 17;42(2):159-165. Epub 2018 Dec 17.

Service d'Ophtalmologie, hôpital Morvan, CHU de Brest, 2, avenue Foch, 29609 Brest, France.

Purpose: To assess the success rate of a matrix regenerating agent (RGTA) in the treatment of chronic corneal ulcers resistant to conventional treatments.

Methods: Uncontrolled prospective observational study in patients with corneal neurotrophic ulcer (Stage 2 or 3 of the Mackie classification), unresponsive to standard medical or surgical treatments and managed with RGTA as an adjunctive treatment. Corneal ulcers were evaluated using slit-lamp examination and optical coherence tomography after 2 weeks, 1 month, 2 months and 3 months. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.05.009DOI Listing
February 2019

[Cold Plasma to Treat Therapy-Refractive Corneal Ulcers].

Klin Monbl Augenheilkd 2018 Dec 19;235(12):1366-1370. Epub 2018 Dec 19.

Augenklinik, Universitätsklinik Erlangen, Erlangen.

Background: The integrity of the ocular surface and the transparency of the cornea is crucial to obtain a good visual acuity - a requirement to actively participate in both social and professional environments. The homeostasis of the ocular surface is constantly endangered by microbes and by intrinsic factors with negative influence on wound healing. Furthermore, widespread use of contact lenses obtain a risk of corneal infection even resulting in corneal perforation and loss of the eye. Read More

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http://dx.doi.org/10.1055/a-0792-1301DOI Listing
December 2018
6 Reads

Pilot Study of the Safety and Tolerability of a Subconjunctival Penciclovir Implant in Cats Experimentally Infected with Herpesvirus.

J Ocul Pharmacol Ther 2019 Jan/Feb;35(1):38-49. Epub 2018 Dec 18.

1 Department of Surgical and Radiological Sciences, University of California-Davis, Davis, California.

Purpose: To assess safety and tolerability of a subconjunctival penciclovir implant in cats infected with feline herpesvirus type 1 (FHV-1).

Methods: Subconjunctival blank (n = 4 cats) or penciclovir-impregnated (n = 6) silicone implants were placed bilaterally in 10 normal, FHV-1-naive cats 7-8 days before viral inoculation. Outcomes included disease score, FHV-1 serology, conjunctival viral load, Schirmer tear tests (STT), tear film break-up times (TFBUTs), conjunctival histology, goblet cell density (GCD), body weight, tear and plasma penciclovir concentration, and corneal ulcer evaluation. Read More

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http://dx.doi.org/10.1089/jop.2018.0043DOI Listing
December 2018

Outcome of therapeutic penetrating keratoplasty in advanced infectious keratitis.

J Curr Ophthalmol 2018 Dec 26;30(4):315-320. Epub 2018 Apr 26.

Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Jolly Grant, Dehradun, India.

Purpose: This study aimed to evaluate the anatomical, therapeutic, and functional outcome of therapeutic penetrating keratoplasty (TPK) in terms of success and failure.

Methods: In this retrospective study 57 eyes of 57 patients were reviewed. They had undergone TPK from December 2012 to June 2017. Read More

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http://dx.doi.org/10.1016/j.joco.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276621PMC
December 2018

Vernal Keratoconjunctivitis.

Surv Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Vernal keratoconjunctivitis, a chronic bilateral seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases, the disease is recurrent and leads to long-term visual disabling complications such as keratoconus and limbal stem cell deficiency. The main pathogenic mechanism is immunoglobulin E mediated; however, there may be non-immunoglobulin E and certain nonspecific hypersensitivity mechanisms. Read More

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http://dx.doi.org/10.1016/j.survophthal.2018.12.001DOI Listing
December 2018
2 Reads

[Clinical picture and diagnosis of neurotrophic keratopathy].

Authors:
E M Messmer

Ophthalmologe 2019 Feb;116(2):120-126

Augenklinik, Ludwig-Maximilians-Universität München, Mathildenstr. 8, 80336, München, Deutschland.

Background: Neurotrophic keratopathy is characterized by corneal surface alterations, persistent corneal epithelial defects and/or corneal ulcerations associated with corneal sensory abnormalities. Due to the variable clinical picture neurotrophic keratopathy is often overlooked or diagnosed too late in the course of the disease.

Objective: Discussion of the clinical picture of neurotrophic keratopathy and recommendations for correct diagnosis. Read More

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http://link.springer.com/10.1007/s00347-018-0822-x
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http://dx.doi.org/10.1007/s00347-018-0822-xDOI Listing
February 2019
5 Reads

[Therapeutic efficacy of ultraviolet combined with riboflavin for the rabbit bacterial keratitis].

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):902-910

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.

To study the effects of ultraviolet light combined with riboflavin treatment (corneal collagen-crosslinking, CXL) on infectious control and stromal reconstruction of bacterial keratitis. Experimental Study. A Staphylococcus aureus rabbit keratitis model was established by injecting Staphylococcus aureus broth into the shallow stromal layer of the right eye cornea of New Zealand white rabbits. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.12.007DOI Listing
December 2018
1 Read

Exposure, entropion, and bilateral corneal ulceration in a newborn as a manifestation of chromosome 22 q11.2 duplication syndrome.

Am J Ophthalmol Case Rep 2019 Mar 4;13:16-19. Epub 2018 Nov 4.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Purpose: Chromosome 22q11.2 micro-duplication syndrome (MDS), is a rare autosomal dominant condition, with a highly variable phenotype that ranges from unremarkable and asymptomatic, to fatal due to cardiovascular defects. Hypertelorism, downslanting palpebral fissures, superior displacement of the eyebrows, and ptosis are the most commonly reported ocular manifestations. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247406PMC
March 2019
1 Read

The epidemiology of nonviral microbial keratitis in a tertiary care center in Muscat, Oman.

Oman J Ophthalmol 2018 Sep-Dec;11(3):213-219

Department of Ophthalmology, Al-Nahdah Hospital, Muscat, Oman.

Objective: The objective of this study is to describe the epidemiology, risk factors, etiology, and outcome of microbial keratitis in a tertiary care center in Muscat, Oman.

Methods: The electronic records of all patients diagnosed with keratitis or corneal ulcer between January 2013 and January 2016 in Al-Nahdha Hospital were retrospectively reviewed. Patients who presented with a corneal ulcer requiring admission and who underwent culture and sensitivity studies were included in the study. Read More

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http://dx.doi.org/10.4103/ojo.OJO_4_2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219341PMC
December 2018
2 Reads

Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis.

Clin Ophthalmol 2018 24;12:2121-2128. Epub 2018 Oct 24.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand,

Purpose: The aim of this study was to investigate the incidence of and risk factors for secondary ocular hypertension (OHT) in patients with moderate to severe infectious ulcerative keratitis and to evaluate the long-term outcome of patients with secondary OHT.

Patients And Methods: A retrospective chart review of 346 patients with moderate to severe infectious keratitis admitted to Siriraj Hospital during the period from 1 January 2005 to 31 May 2008 was conducted. Secondary OHT was defined as intraocular pressure (IOP) greater than 21 mmHg or a consistent demonstration of higher IOP in the affected eye of 8 mmHg or greater, at any time before resolution of the ulcer. Read More

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http://dx.doi.org/10.2147/OPTH.S169280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207220PMC
October 2018
2 Reads

Alternations of interhemispheric functional connectivity in corneal ulcer patients using voxel-mirrored homotopic connectivity: a resting state fMRI study.

Acta Radiol 2018 Nov 27:284185118815308. Epub 2018 Nov 27.

1 Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang, Jiangxi, PR China.

Background: Corneal ulcer (CU) is the second ocular disease leading to blindness. Millions of people around the world suffer from CU. However, the relationship between CU and altered functional connectivity in the brain is still unknown. Read More

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http://dx.doi.org/10.1177/0284185118815308DOI Listing
November 2018
10 Reads

Pellucid marginal degeneration: Detection, discrimination from other corneal ectatic disorders and progression.

Cont Lens Anterior Eye 2018 Nov 22. Epub 2018 Nov 22.

Group of Optics and Visual Perception. Department of Optics, Pharmacology and Anatomy, University of Alicante, Spain. Electronic address:

Pellucid marginal degeneration (PMD) is a non-inflammatory ectatic corneal disease characterized by a narrow band of corneal thinning separated from the limbus by a relatively uninvolved area 1-2 mm in width. It is a rare corneal disorder that shares many clinical characteristics with other corneal ectasias, such as keratoconus, keratoglobus or Terrien marginal degeneration. PMD usually starts later in life than keratoconus and progresses slower than keratoconus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13670484183094
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http://dx.doi.org/10.1016/j.clae.2018.11.010DOI Listing
November 2018
9 Reads

Long-term outcome of using Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) as a drug delivery system for bevacizumab in the treatment of corneal neovascularization.

Ocul Surf 2019 Jan 20;17(1):134-141. Epub 2018 Nov 20.

Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.

Purpose: To report the long-term outcome of Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) for delivery of bevacizumab in the treatment of corneal neovascularization (KNV).

Methods: Retrospective, non-comparative, interventional case series of 13 sequential patients treated for KNV at the BostonSight between 2006 and 2017. In all cases, PROSE treatment was initiated for management of ocular surface disease and patients wore PROSE consistently on a daily wear basis prior to bevacizumab treatment. Read More

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http://dx.doi.org/10.1016/j.jtos.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340761PMC
January 2019
18 Reads

Ocular Surface Diseases in Marine Mammals.

Vet Clin North Am Exot Anim Pract 2019 Jan;22(1):35-51

Ophthalmology Department, All Animal Eye Care, Inc, 505 Commerce Way, Jupiter, FL 33458, USA; Department of Molecular Biomedical Sciences, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address:

Marine mammal eyes are adapted for underwater and air environments by increasing the mucins in tear film and having flatter corneas and round crystalline lenses. The cornea and lens are most commonly affected by environmental imbalances. Lack of shade and excessive exposure to sunlight are significant risk factors for keratopathy in pinnipeds, and likely true in cetaceans. Read More

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http://dx.doi.org/10.1016/j.cvex.2018.08.007DOI Listing
January 2019
5 Reads

Increased succinate receptor GPR91 involved in the pathogenesis of Mooren's ulcer.

Int J Ophthalmol 2018 18;11(11):1733-1740. Epub 2018 Nov 18.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, China.

Aim: To investigate the expression of succinate receptor GPR91 and its pathogenic roles in Mooren's ulcer (MU).

Methods: Biopsy specimens were obtained from 7 patients with MU and 6 healthy donors. The expression of GPR91 in MU tissues was evaluated using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC). Read More

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http://dx.doi.org/10.18240/ijo.2018.11.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232339PMC
November 2018
1 Read

Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty.

J Ophthalmol 2018 22;2018:4351460. Epub 2018 Oct 22.

Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Jinan, China.

Purpose: To observe clinical characteristics and treatment outcomes of new onset herpes simplex keratitis (HSK) after keratoplasty.

Methods: Among 1,443 patients (1,443 eyes) who underwent keratoplasty (excluding cases of primary HSK) in Shandong Eye Hospital, 17 patients suffered postoperative HSK. The clinical manifestations, treatment regimens, and prognoses of the patients were evaluated. Read More

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https://www.hindawi.com/journals/joph/2018/4351460/
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http://dx.doi.org/10.1155/2018/4351460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217905PMC
October 2018
64 Reads

Bilateral Ulcerative Keratitis Associated With Afatinib Treatment for Non-Small-cell Lung Carcinoma.

Cornea 2019 Mar;38(3):384-385

Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, NHS Trust, East Grinstead, West Sussex, United Kingdom.

Purpose: To report a case of afatinib-related bilateral ulcerative keratitis.

Methods: An 85-year-old female patient on treatment with afatinib for non-small-cell lung carcinoma presented with progressive redness, pain, and decreased vision in both eyes. Four weeks before the onset of symptoms, afatinib therapy had been commenced at a dose of 40 mg, once daily. Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9668
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http://dx.doi.org/10.1097/ICO.0000000000001808DOI Listing
March 2019
8 Reads

Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes).

J Feline Med Surg 2018 Nov 12:1098612X18810867. Epub 2018 Nov 12.

1 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

Objectives: The aim of this study was to describe the clinical findings, diagnostic test results and response to therapy of cats with Schirmer tear test 1 (STT-1) values below the reference interval.

Methods: The medical records of three institutions were searched for cats with ocular surface disease and STT-1 values <9 mm/min, confirmed at two or more separate visits.

Results: Ten cats (17 eyes) were included. Read More

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http://dx.doi.org/10.1177/1098612X18810867DOI Listing
November 2018
1 Read

[Contact lens complications : Diagnosis and treatment].

Ophthalmologe 2018 Dec;115(12):1087-1102

Praxis und Expert-Institut, Gammertinger Str. 33, 88499, Riedlingen, Deutschland.

Contact lens complications are all pathological alterations of the eyes caused by wearing contact lenses. Clinical manifestations particularly affect the cornea and conjunctiva. A differentiation is made between undesired manifestations and disease conditions that at least temporarily make the further wearing of contact lenses impossible. Read More

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http://link.springer.com/10.1007/s00347-018-0812-z
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http://dx.doi.org/10.1007/s00347-018-0812-zDOI Listing
December 2018
14 Reads

High-Dose Steroid Treatment of Bacterial Keratitis.

Cornea 2019 Feb;38(2):135-140

School of Optometry and Vision Science, University of New South Wales, Australia.

Purpose: To describe the usage patterns of steroids in bacterial keratitis and to analyze the effect of steroids on patients' visual outcomes.

Methods: This was a single-center retrospective review of patients with culture-positive bacterial keratitis treated between 1999 and 2015 at Princess Alexandra Hospital (Brisbane, Australia). Patients with culture-positive bacterial keratitis were identified through the Queensland Pathology Database, and clinical information was gathered through a subsequent medical record review. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001794DOI Listing
February 2019
3 Reads

Superficial keratectomy as a treatment for non-healing corneal ulceration associated with primary corneal endothelial degeneration.

Vet Ophthalmol 2018 Oct 26. Epub 2018 Oct 26.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Objective: To analyze a study population of dogs with primary corneal endothelial degeneration (PCED) for information on the patterns of disease and to report the efficacy of superficial keratectomy (SK) for resolution of non-healing corneal ulcers associated with PCED.

Animals Studied: Primary corneal endothelial degeneration was diagnosed in 238 dogs between 1998 and 2017. Corneal ulceration associated with PCED was present in 89 dogs (109 eyes), of which 47 eyes were treated with SK. Read More

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http://doi.wiley.com/10.1111/vop.12617
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http://dx.doi.org/10.1111/vop.12617DOI Listing
October 2018
4 Reads

Sight-threatening Graves' orbitopathy: Twenty years' experience of a multidisciplinary thyroid-eye outpatient clinic.

Clin Endocrinol (Oxf) 2019 Jan 19;90(1):208-213. Epub 2018 Nov 19.

Department of Endocrinology, Metabolic Diseases and Nutrition, Hôpital Larrey, University Hospital Centre, Toulouse, France.

Context: Sight-threatening Graves' orbitopathy affects 3% to 5% of patients with Graves' orbitopathy.

Objectives: To describe the management of patients with sight-threatening Graves' orbitopathy seen in a multidisciplinary thyroid-eye outpatient clinic dedicated to Graves' orbitopathy (GO).

Patients And Methods: We enrolled all patients with sight-threatening GO (dysthyroid optic neuropathy and corneal ulcer as defined in the EUGOGO statement) seen and treated in our GO multidisciplinary thyroid-eye outpatient clinic over the last two decades. Read More

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http://dx.doi.org/10.1111/cen.13880DOI Listing
January 2019
7 Reads

Management Algorithm for Fungal Keratitis: The TST (Topical, Systemic, and Targeted Therapy) Protocol.

Cornea 2019 Feb;38(2):141-145

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To evaluate the efficacy of the topical, systemic and targeted therapy (TST) protocol in management of fungal keratitis.

Method: All cases of treatment-naive smear- or culture-proven fungal keratitis presenting between June 2013 and May 2017 were recruited. The TST protocol included initial treatment with topical natamycin 5% with addition of oral ketoconazole or voriconazole in ulcers with size >5 mm, depth >50%, or impending perforation. Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9670
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http://dx.doi.org/10.1097/ICO.0000000000001781DOI Listing
February 2019
5 Reads
2.360 Impact Factor

Stenciling-Based "Prick and Print" Technique for Harvesting Shaped Corneal Grafts for Management of Peripheral Corneal Perforations.

Cornea 2019 Jan;38(1):105-109

Department of Cornea and Refractive Services, Sadguru Seva Sang Trust, Chitrakoot, Madhya Pradesh, India.

Purpose: To evaluate a new surgical technique ("prick and print") for harvesting shaped donor corneal grafts in cases with perforated peripheral ulcerative keratitis (PUK).

Methods: We conducted a retrospective case series at a tertiary center. Medical records of 13 patients with perforated PUK, who underwent tectonic eccentric keratoplasty using the stenciling-based prick and print technique during the past 1 year, were reviewed. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001774DOI Listing
January 2019
3 Reads

Ophtalmoplegia complicating sino-orbital mucormycosis.

Tunis Med 2018 Mar;96(3):224-226

Purpose: To report a case of complete ophthalmoplegia and blindness in sino-orbital mucormycosis.

Case Report: A 68-year-old woman with history of diabetes and breast cancer presented with sudden onset of fever, orbital pain and blindness in the right eye. The patient was found to have no light perception, complete ophthalmoplegia, chemosis, corneal ulcer and optic nerve atrophy. Read More

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March 2018
2 Reads

Orbital decompression in the system of treatment for complicated thyroid eye disease: case report and literature review.

Int Med Case Rep J 2018 1;11:243-249. Epub 2018 Oct 1.

Endocrinology Research Centre, Moscow, Russia,

Orbital decompression is a surgical procedure aimed at increasing the orbital volume and/or decreasing the volume of the orbital fat. The indications for orbital decompression are determined in the course of thorough eye examination. An important objective of examination of a patient with thyroid eye disease (TED) is determination of inflammation activity and severity. Read More

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https://www.dovepress.com/orbital-decompression-in-the-syste
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http://dx.doi.org/10.2147/IMCRJ.S164372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171517PMC
October 2018
6 Reads

Corneal ulcer as the presenting feature of type 2 diabetes mellitus.

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Ophthalmology, County Hospital Hereford, Hereford, UK.

A 60-year-old woman, with no significant medical or ophthalmic history, presented with a unilateral large corneal ulcer and hypopyon. Despite a severely injected conjunctiva and large corneal epithelial defect, the patient denied any discomfort in the eye. The ulcer was extremely slow to heal requiring prolonged treatment with topical and systemic broad-spectrum antibiotics. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22555
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http://dx.doi.org/10.1136/bcr-2018-225557DOI Listing
October 2018
16 Reads

Terrien marginal degeneration.

Surv Ophthalmol 2019 Mar - Apr;64(2):162-174. Epub 2018 Oct 12.

HDR Research Center, Hoopes Vision, Draper, UT, United States; John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, United States; Department of Biology, University of Utah, Salt Lake City, Utah, United States; Utah Lions Eye Bank, Murray, UT, United States. Electronic address:

Terrien marginal degeneration, a rare disease resulting in peripheral corneal thinning, commonly occurs in middle-aged males and usually manifests clinically with decreased visual acuity from increased corneal astigmatism. Although the exact etiology is unknown, hypotheses focus on possible degenerative and inflammatory origins. Histopathologic studies often reveal characteristic findings of innumerable intracellular and extracellular vacuoles in the affected stroma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396257183004
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http://dx.doi.org/10.1016/j.survophthal.2018.09.004DOI Listing
October 2018
11 Reads

Topical Treatment of Persistent Epithelial Defects with a Matrix Regenerating Agent.

J Ocul Pharmacol Ther 2018 Nov 12;34(9):621-627. Epub 2018 Oct 12.

Department of Ophthalmology, School of Medicine, Marmara University , Istanbul, Turkey .

Purpose: The aim of the study was to assess the efficacy of a topical regenerating agent (RGTA) for management of persistent epithelial defects (PEDs) resistant to conventional therapy.

Methods: Twenty-one patients (23 eyes) with PEDs despite the use of conventional therapy for lagophthalmos (n = 4), neurotrophic ulcer (n = 9), chemical burn (n = 3), Stevens-Johnson syndrome (n = 1), atopic keratoconjunctivitis (n = 1), severe dry eye (n = 2), peripheral ulcerative keratitis (n = 1), fungal keratitis (n = 1), and bacterial keratitis (n = 1) were enrolled in the study. Patients were treated with RGTA (Cacicol; Thea, Paris, France) instilled at a dosage of one drop on alternate days. Read More

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https://www.liebertpub.com/doi/10.1089/jop.2018.0025
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http://dx.doi.org/10.1089/jop.2018.0025DOI Listing
November 2018
23 Reads

Effects of topical ophthalmic application of 0.5% proparacaine hydrochloride on aerobic bacterial culture results for naturally occurring infected corneal ulcers in dogs.

J Am Vet Med Assoc 2018 Nov;253(9):1140-1145

OBJECTIVE To evaluate the effects of topical ophthalmic application of 0.5% proparacaine hydrochloride solution (PHCL; containing 0.01% benzalkonium chloride as preservative) on aerobic bacterial culture results for naturally occurring infected corneal ulcers in dogs. Read More

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https://avmajournals.avma.org/doi/10.2460/javma.253.9.1140
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http://dx.doi.org/10.2460/javma.253.9.1140DOI Listing
November 2018
3 Reads

Characterization of virulence factors, antimicrobial resistance patterns and biofilm formation of Pseudomonas aeruginosa and Staphylococcus spp. strains isolated from corneal infection.

J Fr Ophtalmol 2018 Nov 3;41(9):823-829. Epub 2018 Oct 3.

Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction: Infectious keratitis is a serious ocular infection that can lead to severe visual impairment and blindness. Bacterial pathogens are responsible for nearly half of infectious keratitis cases. This study was performed to determine the virulence factors, antimicrobial resistance patterns, and biofilm formation ability of Pseudomonas aeruginosa and Staphylococcus spp. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.01.012DOI Listing
November 2018

[First report of a case of fungal keratitis due to Curvularia hominis in Spain].

Rev Iberoam Micol 2018 Jul - Sep;35(3):155-158. Epub 2018 Sep 28.

Servicio de Microbiología y Parasitología, Hospital Universitario de la Princesa, Madrid, España.

Background: Dematiaceous fungal genus Curvularia is a causal agent of keratitis, onychomycosis, and skin infections. In 2014, using DNA sequencing techniques, five new species, including Curvularia hominis, were described. In this article, a report is presented on the first clinical case of C. Read More

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http://dx.doi.org/10.1016/j.riam.2018.03.004DOI Listing
September 2018
2 Reads

A Case of Animal and Domestic Abuse Initially Diagnosed as Legg-Calve-Perthes Disease.

J Am Anim Hosp Assoc 2018 Nov/Dec;54(6):e54603. Epub 2018 Oct 1.

From the Department of Small Animal Medicine and Surgery, University of Georgia, Athens, Georgia (I.R.); and Athens Area Humane Society, Athens, Georgia (J.M.).

A 1 yr old castrated male shih tzu was evaluated for an acute right rear limb lameness and hyphema in the anterior chamber of the right eye. On initial examination, the dog was non-weight bearing on his right rear limb. Ophthalmic examination revealed a centrally located, superficial corneal ulcer in the right eye and blood in the anterior chamber. Read More

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http://dx.doi.org/10.5326/JAAHA-MS-6611DOI Listing
October 2018
9 Reads

Resolution of fluoroquinolone-resistant keratitis with a PROSE device for enhanced targeted antibiotic delivery.

Am J Ophthalmol Case Rep 2018 Dec 12;12:73-75. Epub 2018 Sep 12.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.

Purpose: To report the resolution of a fluoroquinolone-resistant keratitis with use of a prosthetic replacement of the ocular surface ecosystem (PROSE) device for enhanced targeted delivery of moxifloxiacin.

Observations: A 62-year-old female presented with a 3-day history of pain, photophobia, and declining vision in left eye. The patient had a 2-year history of binocular PROSE treatment for ocular chronic graft-vs-host disease (cGVHD). Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159334PMC
December 2018
7 Reads

Response to comment on: Continuous intraoperative optical coherence tomography-guided shield ulcer debridement with tuck in multilayered amniotic membrane transplantation.

Indian J Ophthalmol 2018 10;66(10):1521-1522

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.4103/ijo.IJO_1029_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173021PMC
October 2018
1 Read
0.930 Impact Factor