893 results match your criteria Corneal Topography and Imaging


A new technique for fitting of tricurve rigid gas-permeable contact lens in penetrating keratoplasty eyes using Scheimpflug imaging.

Indian J Ophthalmol 2020 Jun;68(6):1057-1060

Tej Kohli Cornea Institute, Bausch and Lomb Contact Lens Centre, L V Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana, India.

Purpose: Rigid gas-permeable (RGP) contact lens fitting after penetrating keratoplasty (PK) is challenging due to significant irregular astigmatism. The aim of the study was to determine a guideline for selecting the initial base curve (BC) of the RGP contact lens fitting in post PK eyes.

Methods: The data of patients who had tricurve RGP contact lens fitting post PK were collected retrospectively. Read More

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http://dx.doi.org/10.4103/ijo.IJO_936_19DOI Listing

Corneal Astigmatism Measurements Comparison among Ray-Tracing Aberrometry, Partial Coherence Interferometry, and Scheimpflug Imaging System.

J Ophthalmol 2020 1;2020:3012748. Epub 2020 Apr 1.

Shanxi Eye Hospital, Taiyuan, Shanxi, China.

Purpose: To investigate interdevice agreement among corneal topography/ray-tracing aberrometry (iTrace), partial coherence interferometry (IOLMaster), and Scheimpflug imaging (Pentacam) for the measurement of corneal astigmatism.

Methods: The analysis included 90 eyes of 90 subjects without ocular disease. The main outcome measures were corneal cylinder power and axis of astigmatism. Read More

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http://dx.doi.org/10.1155/2020/3012748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152950PMC

Influence of micropatterned substrates on keratocyte phenotype.

Sci Rep 2020 Apr 21;10(1):6679. Epub 2020 Apr 21.

Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland.

Substrate topographic patterning is a powerful tool that can be used to manipulate cell shape and orientation. To gain a better understanding of the relationship between surface topography and keratocyte behavior, surface patterns consisting of linear aligned or orthogonally aligned microchannels were used. Photolithography and polymer molding techniques were used to fabricate micropatterns on the surface of polydimethylsiloxane (PDMS). Read More

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http://dx.doi.org/10.1038/s41598-020-62640-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174307PMC

Effect of substrate topography on the regulation of human corneal stromal cells.

Colloids Surf B Biointerfaces 2020 Jun 12;190:110971. Epub 2020 Mar 12.

Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland; Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, University of Dublin, Dublin, Ireland. Electronic address:

Optimal functionality of native corneal stroma depends on a well-ordered arrangement of extracellular matrix (ECM). To develop an in vitro corneal model, replication of the corneal in vivo microenvironment is needed. In this study, the impact of topographic cues on keratocyte phenotype is reported. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.110971DOI Listing

Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus.

Clin Ophthalmol 2020 28;14:589-595. Epub 2020 Feb 28.

Department of Ophthalmology, Cairo University, Giza, Egypt.

Purpose: To evaluate the corneal pachymetric and topographic parameters of systemic Lupus Erythematosus (SLE) patients using Dual Scheimpflug Imaging.

Methods: This observational cross-sectional controlled study included the right eye of 30 SLE patients and 30 age-matched controls. Corneal measurements were acquired by dual Scheimpflug imaging including anterior and posterior corneal curvatures, central, mid-peripheral corneal thickness (measured at the 5 mm zone) and peripheral pachymetry (measured at the 7 mm zone). Read More

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http://dx.doi.org/10.2147/OPTH.S234568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053818PMC
February 2020

Comparing the postoperative refractive predictability of Pentacam HR and IOLMaster 500 after a multifocal intraocular lens implantation.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):141-145

Departamento de Oftalmologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Purpose: To compare the postoperative refractive predictability of IOLMaster 500 and Pentacam HR on the basis of keratometry and anterior chamber depth values in eyes with an indication for multifocal intraocular lens (IOL) implantation.

Methods: This was a retrospective study conducted on 118 eyes treated with phacoemulsification and multifocal intraocular lens implantation. Only the eyes that achieved emmetropia in the dynamic refraction performed on postoperative day 30 were included. Read More

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http://dx.doi.org/10.5935/0004-2749.20200026DOI Listing

Structural Characterization of Glaucoma Patients with Low Ocular Blood Flow.

Curr Eye Res 2020 Mar 12:1-7. Epub 2020 Mar 12.

Department of Ophthalmology, Graduate School of Medicine, Tohoku University, Sendai, Japan.

: There is an unclear relationship between ocular blood flow (OBF) and the structural characteristics of the optic nerve head (ONH) in glaucoma, a multifactorial disease. This study used laser speckle flowgraphy (LSFG) to identify low-OBF glaucoma patients and investigated the ONH in these patients.: In 533 eyes with glaucoma, we determined confounding factors for LSFG-measured OBF (tissue-area mean blur rate: MT) and corrected MT with a linear mixed-effects model (LMM). Read More

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http://dx.doi.org/10.1080/02713683.2020.1736306DOI Listing

Diurnal variation of anterior segment parameters handled with Scheimpflug imaging in keratoconus patients.

Int Ophthalmol 2020 Jun 19;40(6):1481-1485. Epub 2020 Feb 19.

Ophthalmology Department, Kayseri City Education and Research Hospital, Building of Pschiatry 1st Floor Ophthalmology Service, Kocasinan, Kayseri, Turkey.

Purpose: To define diurnal changes in anterior segment parameters of keratoconus patients by using Scheimpflug imaging.

Methods: All keratoconus patients had corneal topography measurements 3 times a day (around 09:00 AM, 13:00 PM and 17:00 PM) by the same experienced operator. Three consecutive scans in each measurement session were obtained. Read More

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http://dx.doi.org/10.1007/s10792-020-01315-6DOI Listing

Association between keratoconus disease severity and repeatability in measurements of parameters for the assessment of progressive disease.

PLoS One 2020 14;15(2):e0228992. Epub 2020 Feb 14.

Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark.

Background: Progressive keratoconus can lead to severely impaired vision, but there is currently no consensus on the definition of progressive disease. Errors in the measurement of the parameters commonly used to establish progressive disease were evaluated in an attempt to determine the limits at which a true change in the values can be detected. The possible association between measurement error and disease severity was also investigated to evaluate the need for limits based on disease severity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228992PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021304PMC

Biomechanical diagnostics of the cornea.

Eye Vis (Lond) 2020 5;7. Epub 2020 Feb 5.

Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro, Brazil.

Corneal biomechanics has been a hot topic for research in contemporary ophthalmology due to its prospective applications in diagnosis, management, and treatment of several clinical conditions, including glaucoma, elective keratorefractive surgery, and different corneal diseases. The clinical biomechanical investigation has become of great importance in the setting of refractive surgery to identify patients at higher risk of developing iatrogenic ectasia after laser vision correction. This review discusses the latest developments in the detection of corneal ectatic diseases. Read More

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http://dx.doi.org/10.1186/s40662-020-0174-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001259PMC
February 2020

[Comparison of keratometric measurements obtained by the Verion image guided system with the IOLMaster and the Pentacam before cataract extraction surgery].

Zhonghua Yan Ke Za Zhi 2020 Jan;56(1):47-52

Department of Ophthalmology, Tenth People's Hospital Affiliated to Tongji University, Shanghai 200072, China.

To compare the keratometric measurements of the Verion image guided system with the partial coherence interferometry (IOLMaster700) and the scheimpflug corneal topography (Pentacam). In this cross-sectional study, 146 eyes of 88 patients [mean age, (69±10) years; 62 eyes of male patients and 84 eyes of female patients] with cataract were examined before cataract extraction and IOL implantation surgery in the Tenth People's Hospital Affiliated to Tongji University from January 2016 to March 2017. Corneal curvature values acquired by the Verion optical imaging system were compared with the IOLMaster700 and the Pentacam. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2020.01.012DOI Listing
January 2020

A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus.

J Optom 2020 Jan 5. Epub 2020 Jan 5.

School of Health Sciences, Department of Optometry, University of Kwazulu Natal, Durban, South Africa.

Background: Keratoconus (KC) is a corneal ectasia characterised by steepening corneal curvature, changes in refractive error and corneal thickness that result in visual impairment. Early signs of KC include displacement of the thinnest part of the cornea from the central position, changes in the corneal epithelial layer cell distribution, variations in the anterior corneal astigmatism/posterior corneal astigmatism relationship and a variation in corneal thickness. It is important that we review the corneal imaging methods for the diagnosis of preclinical KC. Read More

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http://dx.doi.org/10.1016/j.optom.2019.11.001DOI Listing
January 2020

The importance of corneal assessment in a glaucoma suspect - a review.

Rom J Ophthalmol 2019 Oct-Dec;63(4):321-326

"Carol Davila" University of Medicine and Pharmacy Bucharest, Romania.

Glaucoma represents the main cause of irreversible blindness in the world and for this consideration, the interest in a quick and precise diagnosis and progression of the disease, prior to the appearance of irreversible damage, has been continuously rising. Glaucoma risk factors are already well known, but current studies reveal that it is necessary to make a proper analysis of the intraocular pressure (IOP) to obtain an accurate diagnosis, so we must take into consideration corneal properties that might affect IOP measurements. Starting from corneal geometrical properties represented by central corneal thickness (CCT) and continuing with biomechanical properties represented by corneal hysteresis (CH) and corneal resistance factor (CRF) we reviewed the value of investigating corneal properties in ocular hypertension (OH), primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943289PMC

Simulation of Air Puff Tonometry Test Using Arbitrary Lagrangian-Eulerian (ALE) Deforming Mesh for Corneal Material Characterisation.

Int J Environ Res Public Health 2019 12 19;17(1). Epub 2019 Dec 19.

School of Engineering, University of Liverpool, Liverpool L69 3GH, UK.

Purpose: To improve numerical simulation of the non-contact tonometry test by using arbitrary Lagrangian-Eulerian deforming mesh in the coupling between computational fluid dynamics model of an air jet and finite element model of the human eye.

Methods: Computational fluid dynamics model simulated impingement of the air puff and employed Spallart-Allmaras model to capture turbulence of the air jet. The time span of the jet was 30 ms and maximum Reynolds number was Re=2. Read More

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http://dx.doi.org/10.3390/ijerph17010054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982245PMC
December 2019
2.063 Impact Factor

Corneal differences between healthy and subclinical patients assessed using two diferente corneal tomographers.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):92-97

Department of Ophthalmology, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010050, China.

Purpose: To analyze subclinical keratoconus topography indexes using Pentacam and Orbscan-II measurements to identify evidences for seeking sensitive indexes to screen and diagnose subclinical keratoconus.

Methods: Fifty healthy participants (50 eyes) and 40 patients with subclinical keratoconus (40 eyes) were included. Seven common parameters including corneal thickness at the thinnest point; minimum curvature of the front surface (minimum simulated keratometry value, SimK's Min); maximum curvature of the front surface (maximum simulated keratometry value, SimK's Max); the frontal corneal surface best-fit spherical radius of the curvature; the back corneal surface best-fit spherical radius of curvature; the anterior corneal surface height (anterior Diff value); and the posterior corneal surface height (posterior Diff value) measured by Pentacam and Orbscan-II between normal and subclinical keratoconus eyes were compared. Read More

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http://dx.doi.org/10.5935/0004-2749.20200015DOI Listing

A high-throughput microfluidic method for fabricating aligned collagen fibrils to study Keratocyte behavior.

Biomed Microdevices 2019 11 18;21(4):99. Epub 2019 Nov 18.

Department of Bioengineering, University of Texas at Dallas, 800 W. Campbell Rd, Richardson, TX, 75080, USA.

In vivo, keratocytes are surrounded by aligned type I collagen fibrils that are organized into lamellae. A growing body of literature suggests that the unique topography of the corneal stroma is an important regulator of keratocyte behavior. In this study we describe a microfluidic method to deposit aligned fibrils of type I collagen onto glass coverslips. Read More

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http://dx.doi.org/10.1007/s10544-019-0436-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228026PMC
November 2019

Corneal topography in clinical practice.

J Fr Ophtalmol 2019 Dec 11;42(10):e439-e451. Epub 2019 Nov 11.

Service opthalmologie, CHU de Pontchaillou, 2, rue Henri-le-Guilloux, 35000 Rennes, France.

Developments in corneal topography allow for increasingly precise, detailed analysis of the corneal surface. This test is becoming indispensable in the treatment of complex corneas: keratoconus, corneal transplants, orthokeratology, etc. In refractive surgery, the combined analysis of the anterior and posterior cornea has permitted better screening for forme fruste keratoconus at risk for post-LASIK ectasia. Read More

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http://dx.doi.org/10.1016/j.jfo.2019.09.001DOI Listing
December 2019

Corneal Viscous Properties Cannot Be Determined From Air-Puff Applanation.

J Refract Surg 2019 Nov;35(11):730-736

Purpose: To assess whether corneal viscous properties are measureable with air-puff applanation in patients.

Methods: The study had 312 normal eyes, 107 fellow eyes of patients with keratoconus, and 289 keratoconic eyes. The Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) deformation data for all eyes were analyzed using two models. Read More

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http://dx.doi.org/10.3928/1081597X-20191010-03DOI Listing
November 2019

Corneal sublayer thickness in patients with pseudoexfoliation syndrome evaluated by anterior segment optical coherence tomography.

Int Ophthalmol 2020 Mar 7;40(3):563-570. Epub 2019 Nov 7.

Department of Ophthalmology, The Dunya Goz Eye Hospital, Konya, Turkey.

Purpose: The aim of the study was to evaluate the thickness of each corneal sublayer in patients with pseudoexfoliation syndrome (PXS).

Methods: The study's sample consisted of the 74 eyes of 74 patients with PXS (group 1) and the 80 eyes of 80 individuals without PXS (group 2). Each participant was performed anterior segment optical coherence tomography (AS-OCT) and Pentacam-Scheimpflug imaging. Read More

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http://dx.doi.org/10.1007/s10792-019-01214-5DOI Listing

Successful Treatment of Corneal Opacification with Associated Thickened Epithelium by Simple Peeling: Acquired Corneal Subepithelial Hypertrophy (ACSH).

Saudi J Ophthalmol 2019 Jul-Sep;33(3):203-208. Epub 2019 Feb 13.

Specialized Experts Center, Riyadh, Saudi Arabia.

Purpose: To study clinical and histopathological findings of corneal opacification caused by thickened epithelium leading to reduced vision and topographical changes and to evaluate the outcome of its removal.

Methods: Twelve patients (17 eyes) with central, paracentral or peripheral corneal opacification were reviewed to obtain their visual acuity, describe their slit lamp (SL) appearance (depth, extent and density) and document their topographic changes before and after peeling of the epithelium under SL or surgical removal under the microscope. Specimens of six cases were available for histopathological examination and immunohistochemical staining. Read More

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http://dx.doi.org/10.1016/j.sjopt.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819717PMC
February 2019

Galilei Corneal Tomography for Screening of Refractive Surgery Candidates: A Review of the Literature, Part II.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(3):204-218

HDR Research Center, Hoopes Vision, Draper, UT, USA.

Corneal topography is the most widely used technology for examining the anterior corneal surface. Scheimpflug imaging is a newer technique that allows for measurement of both the anterior and posterior corneal surface, which allows for three-dimensional reconstruction of the cornea. This is of particular interest and value in the field of cataract and refractive surgery. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778460PMC
January 2019

Developments in Imaging of Corneal Biomechanics.

Int Ophthalmol Clin 2019 ;59(4):1-17

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http://dx.doi.org/10.1097/IIO.0000000000000286DOI Listing
January 2020
1 Read

Review on Centration, Astigmatic Axis Alignment, Pupil Size and Optical Zone in SMILE.

Asia Pac J Ophthalmol (Phila) 2019 Sep-Oct;8(5):385-390

International Eye Research Institute of the Chinese University of Hong Kong (Shenzhen), Shenzhen, China.

The advent of "flapless" small-incision lenticule extraction (SMILE), employing all-in-one technology, has resulted in a revolutionary breakthrough in refractive surgeries. SMILE has been gaining popularity due to fewer potential complications, such as postoperative dry eyes and greater biomechanical stability, etc. However, attention must be given to 1) the centration on the corneal vertex, 2) the proper alignment of the astigmatic axis, and 3) the relationship between pupil size and treatment diameter, to achieve good SMILE results. Read More

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http://dx.doi.org/10.1097/01.APO.0000580144.22353.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784779PMC
January 2020
2 Reads

A multimodal ophthalmic analysis in patients with systemic sclerosis using ocular response analyzer, corneal topography and specular microscopy.

Int Ophthalmol 2020 Feb 28;40(2):287-296. Epub 2019 Sep 28.

Ophthalmology Department, Medical School, Manisa Celal Bayar University, Manisa, Turkey.

Purpose: To conduct a multimodal ophthalmic evaluation of systemic sclerosis (SSc) in patients using ocular response analyzer (ORA), Pentacam, and specular microscopy (SM).

Methods: Thirty-one SSc patients and a group of age- and sex-matched controls were enrolled in this cross-sectional study. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and Goldmann-correlated IOP (IOPg) were measured with ORA. Read More

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http://dx.doi.org/10.1007/s10792-019-01173-xDOI Listing
February 2020

Anterior chamber characteristics assessed by rotating Scheimpflug imaging in patients with retinitis pigmentosa.

Arq Bras Oftalmol 2019 12;82(6):507-510. Epub 2019 Sep 12.

Department of Ophthalmology, Kayseri Research and Training Hospital, Kayseri, Turkey.

Purpose: The aim of this study was to evaluate anterior segment parameters and corneal aberrations in patients with retinitis pigmentosa using Scheimpflug imaging and to compare the findings with those for healthy controls.

Methods: This single-center, case-control study included patients diagnosed with retinitis pigmentosa who were followed up at the Department of Ophthalmology of Kayseri Training and Research Hospital between February and June 2018. Age- and sex-matched healthy individuals with no known ophthalmologic disease formed the control group. Read More

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http://dx.doi.org/10.5935/0004-2749.20190096DOI Listing

Relations Among Corneal Curvature, Thickness, and Volume in Keratoconus as Evaluated by Anterior Segment-Optical Coherence Tomography.

Invest Ophthalmol Vis Sci 2019 09;60(12):3794-3802

Ohshima Eye Hospital, Fukuoka, Japan.

Purpose: To provide insight into the mechanism underlying corneal deformation in keratoconus, we examined the relations among corneal curvature, thickness, and volume as well as the association of corneal scar formation with these parameters.

Methods: A total of 288 corneas of 174 keratoconus patients and 114 corneas of 57 control subjects were examined by anterior segment-optical coherence tomography (AS-OCT). Anterior and posterior refractive values, corneal thickness (CT), and corneal volume (CV) were determined by AS-OCT for both control and keratoconic eyes. Read More

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http://dx.doi.org/10.1167/iovs.19-27619DOI Listing
September 2019

One-Year Efficacy and Safety of Combined Photorefractive Keratectomy and Accelerated Corneal Collagen Cross-Linking after Intacs SK Intracorneal Ring Segment Implantation in Moderate Keratoconus.

Biomed Res Int 2019 8;2019:7850216. Epub 2019 Jul 8.

Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.

Purpose: To report one-year outcomes of a modified version of two-stage multimodal surgical protocol for moderate keratoconus which has been suggesting promising preliminary results.

Materials And Methods: 30 eyes of 25 patients with moderate keratoconus who exhibited visual complaints and/or disease progression were included for this retrospective case study. Approximately 3 months after implantation of intracorneal ring segment (Intacs SK™), a combination of corneal wavefront-guided transepithelial photorefractive keratectomy (CWG-transPRK, Schwind Amaris® 1050, and Schwind Sirius) and accelerated collagen cross-linking (accCXL, Avedro KXL™) was performed. Read More

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http://dx.doi.org/10.1155/2019/7850216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644267PMC
January 2020
4 Reads

Topography and Pachymetry Guided, Rapid Epi-on Corneal Cross-Linking for Keratoconus: 7-year Study Results.

Cornea 2020 Jan;39(1):56-62

Department of Medicine and Health Science "V. Tiberio," Università del Molise, Campobasso, Italy.

Purpose: To evaluate custom fast cross-linking (cfCXL) treatment of keratoconus.

Methods: "Custom fast cross-linking" or "cfCXL" is a keratoconus treatment algorithm featuring no epithelial disruption, 15 minutes of corneal presoaking with a riboflavin-vitamin E TPGS solution, and a 370-nm ultraviolet A radiation beam centered on the most highly curved corneal region. Ultraviolet A radiation beam fluence, total energy, and exposure time are significantly less than those in the Dresden protocol. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002088DOI Listing
January 2020
1 Read

Comparison of Corneal Power and Corneal Astigmatism of Different Diameter Zones Centered on the Pupil and Corneal Apex Using Scheimpflug Tomography.

Cornea 2020 Jan;39(1):77-83

Department of Cataract, Shanxi Eye Hospital, Taiyuan, Shanxi, China.

Purpose: Using Scheimpflug tomography to investigate the difference in corneal power and corneal astigmatism between 3- and 4-mm diameter zones centered on the pupil and corneal apex.

Methods: A total of 90 eyes were included in this study. Axial keratometry, total refractive power, and true net power centered on the pupil and corneal apex in 3- and 4-mm diameter zones were assessed. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002052DOI Listing
January 2020
2 Reads

Combined Phototherapeutic Keratectomy, Intracorneal Ring Segment Implantation, and Corneal Collagen Cross-Linking in Keratoconus Management.

Cornea 2019 Oct;38(10):1233-1238

Max Rady College of Medicine, University of Manitoba, MB, Canada.

Purpose: To evaluate the efficacy, predictability, and safety of combined corneal collagen cross-linking (CXL), intracorneal ring segment (ICRS) implantation, and superficial phototherapeutic keratectomy (PTK) in patients with keratoconus.

Methods: Fifty-five eyes received ICRS implantation, followed by CXL and PTK combination treatment. Patients were followed up for 6 months. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002073DOI Listing
October 2019

Posterior segment eye lesions: prevalence and associations with ocular and systemic parameters: results from the Gutenberg Health Study.

Graefes Arch Clin Exp Ophthalmol 2019 Oct 18;257(10):2127-2135. Epub 2019 Jul 18.

NIHR Biomedical Research Center at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.

Background: To estimate the prevalence of posterior segment eye lesions and to identify their ocular and systemic associations within the Gutenberg Health Study (GHS) in Germany.

Methods: Assessment and grading of fundus images as well as physical examination and history taking were performed in the cross-sectional analysis of 15,010 subjects (aged 35-74 years) using standardised procedures to determine the prevalence and associations of various posterior segment eye lesions.

Results: Fundus photographs of both eyes were available for 12,782 (85. Read More

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http://dx.doi.org/10.1007/s00417-019-04416-wDOI Listing
October 2019
1 Read

The comparison of visual outcomes, aberrations, and Bowman's layer micro-distortions after femtosecond laser small-incision lenticule extraction (SMILE) for the correction of high and moderate myopia and myopic astigmatism.

BMC Ophthalmol 2019 Jun 27;19(1):138. Epub 2019 Jun 27.

Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China Shanghai Research Center of Ophthalmology and Optometry, NHC Key Laboratory of Myopia, Shanghai, People's Republic of China.

Background: This study compares the clinical outcomes of femtosecond laser small-incision lenticule extraction (SMILE) for the correction of myopia and myopic astigmatism greater than - 10 D, and - 10 D or less respectively.

Methods: 60 eyes/patients were equally selected into group 1 (myopia and myopic astigmatism of - 10 D or less) and group 2 (myopia and myopic astigmatism of over - 10 D), both of which were treated with SMILE. Visual and refractive outcomes, corneal higher-order aberrations, and Bowman's layer micro-distortions were evaluated preoperatively, 3 months, and 6 months postoperatively. Read More

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http://dx.doi.org/10.1186/s12886-019-1135-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598346PMC
June 2019
4 Reads

Corneal topometric, aberrometric and biomechanical parameters in mucopolysaccharidosis patients.

PLoS One 2019 27;14(6):e0218108. Epub 2019 Jun 27.

Bürgerhospital, Frankfurt am Main, Germany.

Aims: To report corneal topometric and aberrometric values in mucopolysaccharidosis (MPS) and to investigate their correlation with biomechanical corneal parameters.

Methods: One randomly chosen eye of 20 MPS patients with no to moderate corneal clouding and one eye of 23 healthy controls with comparable age were prospectively included into this study. Corneal surface regularity was assessed by index of surface variance (ISV), -vertical asymmetry (IVA), -height asymmetry (IHA), -height decentration (IHD); keratoconus index (KI), central keratoconus index (CKI) and Zernike indices of anterior and posterior corneal surface using Scheimpflug imaging (Pentacam). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218108PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597047PMC
February 2020
3 Reads

The effect of corneal cross-linking on the anterior and posterior parameters of the cornea: A prospective repeatability study.

Rom J Ophthalmol 2019 Jan-Mar;63(1):68-74

Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.

To determine the effect of corneal cross-linking (CXL) on the anterior and posterior corneal indices in terms of their repeatability and change as measured with Pentacam. Thirty eyes of 30 patients with progressive keratoconus undergoing CXL were enrolled. At each visit (pre-CXL, 6 and 12 months after CXL), imaging were done twice, one hour apart to determine the repeatability index (RI) and intra-class correlation coefficient (ICC). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531775PMC
June 2019
1 Read

Comparative analysis of biomechanical parameters of the corneas following Descemet membrane endothelial keratoplasty and contralateral healthy corneas.

Graefes Arch Clin Exp Ophthalmol 2019 Sep 11;257(9):1925-1929. Epub 2019 Jun 11.

Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel.

Purpose: To compare the biomechanical properties of the unilateral operated corneas in patients who had undergone Descemet membrane endothelial keratoplasty (DMEK) for pseudophakic bullous keratopathy (PBK) with those of the contralateral normal corneas.

Methods: This was a retrospective cohort study conducted at university hospitals (Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel, and S. Fyodorov Eye Microsurgery State Institution, Moscow, Russia). Read More

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http://dx.doi.org/10.1007/s00417-019-04387-yDOI Listing
September 2019
12 Reads
1.908 Impact Factor

Large Field of View Corneal Epithelium and Bowman's Layer Thickness Maps in Keratoconic and Healthy Eyes.

Am J Ophthalmol 2020 01 3;209:168-177. Epub 2019 Jun 3.

Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria. Electronic address:

Purpose: To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes.

Design: Cross-sectional study.

Methods: Setting: institutional. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.05.025DOI Listing
January 2020
28 Reads

Long-Term Stability With the Athens Protocol (Topography-Guided Partial PRK Combined With Cross-Linking) in Pediatric Patients With Keratoconus.

Cornea 2019 Aug;38(8):1049-1057

LaserVision Clinical and Research Eye Institute, Athens, Greece.

Purpose: To evaluate the safety, efficacy, and stability of topography-guided partial PRK combined with corneal cross-linking (CXL) (the Athens Protocol [AP]) in pediatric patients with keratoconus over a 4-year follow-up period.

Methods: This prospective study included 39 keratoconic eyes of 21 patients younger than 18 years with clinical and imaging evidence of keratoconus progression. Partial topography-guided excimer laser ablation in conjunction with high-fluence CXL was performed in all patients according to the AP. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001996DOI Listing
August 2019
1 Read

[Distribution of corneal thickness in the Tunisian population: Study by anterior segment optical coherence tomography].

J Fr Ophtalmol 2019 Oct 1;42(8):874-879. Epub 2019 Jun 1.

Faculté de médecine de Tunis, université Tunis El Manar, hôpital Habib Thameur, 3, rue A. Ben Ayed, 1089 Tunis, Tunisie.

Goals: To describe the distribution of the central corneal thickness (CCT) in the Tunisian population.

Methods: A prospective descriptive study was performed in 201 right eyes of 201 randomly selected healthy Tunisian subjects without glaucoma. We measured the spherical error by autorefraction, the axial length using A-scan ultrasound biometry and the central corneal thickness using anterior segment optical coherence tomography (DRI TRITON OCT). Read More

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http://dx.doi.org/10.1016/j.jfo.2019.03.017DOI Listing
October 2019
3 Reads

Bowman's topography for improved detection of early ectasia.

J Biophotonics 2019 10 27;12(10):e201900126. Epub 2019 Jun 27.

Imaging, Biomechanics and Mathematical Modeling Solutions, Narayana Nethralaya Foundation, Bangalore, India.

The aim of this study was to evaluate whether OCT topography of the Bowman's layer and artificial intelligence (AI) can result in better diagnosis of forme fruste (FFKC) and clinical keratoconus (KC). Normal (n = 221), FFKC (n = 72) and KC (n = 116) corneas were included. Some of the FFKC and KC patients had the fellow eye (VAE-NT) with normal topography (n = 30). Read More

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http://dx.doi.org/10.1002/jbio.201900126DOI Listing
October 2019
10 Reads

Prosthetic replacement of the ocular surface ecosystem for corneal irregularity: Visual improvement and optical device characteristics.

Cont Lens Anterior Eye 2019 10 27;42(5):526-532. Epub 2019 May 27.

Contact Lens Services, Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad, India. Electronic address:

Purpose: To describe patterns of prescribing Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) in irregular corneas and compare various components of lens design.

Methods: Design: Retrospective, observational case series. 244 eyes of 173 patients with keratoconus (n=178), pellucid marginal degeneration (n=21), keratoglobus (n=6), following refractive surgery (n=19) and following keratoplasty (n=20) fitted with the PROSE device were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.clae.2019.05.001DOI Listing
October 2019
24 Reads
2.000 Impact Factor

Quantitative evaluation of visual function in patients with cornea verticillata associated with Fabry disease.

Acta Ophthalmol 2019 Dec 24;97(8):e1098-e1104. Epub 2019 May 24.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.

Purpose: To evaluate the visual function of patients with cornea verticillata associated with Fabry disease through quantitative evaluations of contrast sensitivity function and straylight.

Methods: We enrolled 28 eyes of 14 patients with Fabry disease (mean age, 37.1 ± 17. Read More

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http://dx.doi.org/10.1111/aos.14143DOI Listing
December 2019
4 Reads

Correlation between body mass index and ocular parameters.

Clin Ophthalmol 2019 30;13:763-769. Epub 2019 Apr 30.

Department of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.

To investigate the relationship between BMI and selected ocular parameters. Fifty-three left eyes of normal weight subjects and 67 age-sex matched overweight subjects were studied. Inclusion criteria for the normal weight and overweight groups included BMI between 18. Read More

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https://www.dovepress.com/correlation-between-body-mass-inde
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http://dx.doi.org/10.2147/OPTH.S196622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503310PMC
April 2019
13 Reads

Small-incision lenticule addition in ex vivo model of ectatic human corneas.

Int Ophthalmol 2019 Nov 13;39(11):2575-2581. Epub 2019 May 13.

Eye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Policlinico G.B. Rossi, Piazzale L.A. Scuro 10, 37134, Verona, Italy.

Purpose: To investigate the feasibility of intrastromal lenticule insertion to restore corneal shape in a model of ectatic human cornea.

Methods: For this experimental ex vivo study on 34 human corneas unsuitable for transplantation, 17 corneas were thinned by decentralized posterior excimer laser ablation to 200 μm thickness and 6.5 mm diameter and then inflated up to 100 mm Hg to expose the ectasias (recipient corneas). Read More

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http://link.springer.com/10.1007/s10792-019-01106-8
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http://dx.doi.org/10.1007/s10792-019-01106-8DOI Listing
November 2019
20 Reads

Unified approach to tear film surface analysis with high-speed videokeratoscopy.

J Opt Soc Am A Opt Image Sci Vis 2019 Apr;36(4):B15-B22

Placido disk videokeratoscopy, when used in a dynamic acquisition mode, can be utilized for noninvasive assessment of tear film quality. The different commercially available videokeratoscopes that incorporate an automatic option to evaluate tear film do not provide consistent measurements due to differences in their designs as well as differences in the algorithms used to analyze the images. Here, a standardized algorithm that can be applied to different instruments is developed. Read More

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http://dx.doi.org/10.1364/JOSAA.36.000B15DOI Listing

Comparison of keratometric measurements between color light-emitting diode topography and Scheimpflug camera.

BMC Ophthalmol 2019 Apr 26;19(1):98. Epub 2019 Apr 26.

Department of Ophthalmology and Visual Science, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea.

Background: To determine the agreement of measurements between color light-emitting diode corneal topography (Cassini) and Scheimpflug camera keratometry (Pentacam HR).

Methods: The current retrospective study investigated 117 right eyes of 117 healthy patients before cataract surgery from June 2017 to July 2017. Steep K, flat K, mean K, astigmatism, and axis for both anterior and posterior corneal surface were measured using the two devices. Read More

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http://dx.doi.org/10.1186/s12886-019-1106-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486681PMC
April 2019
3 Reads

Repeatability and Reproducibility of Slit Lamp, Optical Coherence Tomography, and Scheimpflug Measurements of Corneal Scars.

Ophthalmic Epidemiol 2019 08 25;26(4):251-256. Epub 2019 Apr 25.

b Department of Ophthalmology , University of California , San Francisco , USA.

: To determine the repeatability and reproducibility of anterior segment optical coherence tomography (AS-OCT) and Scheimpflug photography for several measurements of corneal scars, including scar size, scar depth, and corneal thickness. : A series of patients treated for fungal keratitis at a tertiary eye care center in South India were recalled two years after successful treatment. Eyes with corneal scars had a slit lamp examination performed by two ophthalmologists masked to the other's examination. Read More

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http://dx.doi.org/10.1080/09286586.2019.1600199DOI Listing
August 2019
6 Reads

[Application of Deep Learning in Early Diagnosis Assistant System of Keratoconus].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Mar;43(2):83-85

The Eye Hospital of Wenzhou Medical University, Wenzhou, 325000.

In view of the problem that there is no standard diagnosis for early stage keratoconus disease,at the same time to assist the special examiner and ophthalmologist to make the early diagnosis effectively,the advantages and disadvantages of each testing instrument were analyzed.In order to construct an assistant system for early diagnosis of keratoconus,a deep learning technique was applied in corneal OCT examination.The system used improved VGG-16 to realize the recognition accuracy of about 68% keratoconus keratopathy,and the clinical results showed that the system can help doctors to give diagnosis confidence to a certain extent. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.02.002DOI Listing
March 2019
18 Reads

Configuration of recipient corneal cut after mechanical trephination in keratoconus.

Int Ophthalmol 2019 Nov 9;39(11):2553-2559. Epub 2019 Apr 9.

Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Boostan 9 St., Pasdaran Ave., Tehran, 16666, Iran.

Purpose: To determine the roundness of recipient corneal cuts after mechanical trephination and to investigate possible factors that could affect the corneal bed configuration in deep anterior lamellar keratoplasty (DALK).

Methods: This study enrolled 85 eyes with keratoconus that underwent DALK. Recipient corneas were partially trephined using a new, unused, disposable Hessburg-Barron suction trephine. Read More

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http://link.springer.com/10.1007/s10792-019-01103-x
Publisher Site
http://dx.doi.org/10.1007/s10792-019-01103-xDOI Listing
November 2019
14 Reads

Evaluation of Corneal Morphology in Patients With Hemifacial Spasm.

Eye Contact Lens 2019 Jul;45(4):271-275

Ophtalmology Department (D.M.U., Z.D., A.Ç.) and Neurology Department (E.K.U.), Kayseri Training and Research Hospital, Kayseri, Turkey.

Purpose: To determine whether the corneal topographic parameter values, individual corneal layer thicknesses, and its endothelial layer morphology are different in patients with hemifacial spasm (HFS) than in the control contralateral eye.

Methods: This study was designed as a prospective study. Among patients who applied to our hospital within the past 3-year period, those with HFS in one eye (study eyes) and a completely normal contralateral eye (control eyes) were included in this study. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000597DOI Listing
July 2019
32 Reads