109,318 results match your criteria Corneal Laceration


CYP1B1 Gene and Phenotypic Correlation in Patients from Northeastern Brazil with Primary Congenital Glaucoma.

J Glaucoma 2018 Dec 5. Epub 2018 Dec 5.

Hospital das Clínicas, Federal University of Pernambuco (HC - UFPE), Recife, Pernambuco, Brazil.

Purpose: To identify variants in the CYP1B1 gene in northeastern Brazilian patients with PCG and possible genotype-phenotype correlations.

Materials And Methods: This is a cross-sectional observational study of 17 non-related patients with PCG, performed at the Altino Ventura Foundation, Recife, Brazil, between December 2017 and February 2018. All patients underwent an examination, including gathering information from their medical records, slit lamp examination, fundoscopy, tonography, and measuring corneal diameter and thickness. Read More

View Article
December 2018

Microbial keratitis complicated by acute hydrops following corneal collagen cross-linking for keratoconus.

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, The James Cook University Hospital, Middlesbrough, UK.

View Article
December 2018

The Ocular Status of Cystinosis Patients Receiving a Hospital Pharmacy-Made Preparation of Cysteamine Eye Drops: A Case Series.

Ophthalmol Ther 2018 Dec 5. Epub 2018 Dec 5.

Manchester Royal Eye Hospital, Manchester Academic Health Science Centre, Manchester, UK.

Introduction: Infantile nephropathic cystinosis (INC) is an autosomal recessive lysosomal disorder in which patients develop deposits of cystine crystals in their kidneys and corneas from a young age.

Methods: We conducted a retrospective analysis of children with INC seen by ophthalmologists at the Manchester Royal Eye Hospital between 2002 and 2018, to evaluate clinical findings, symptoms and treatment.

Results: Twenty-two children diagnosed with INC from age 0 (prenatally) to 11 years were assessed. Read More

View Article
December 2018
4 Reads

[Combined XEN and Baerveldt implant-principles and management of complications].

Ophthalmologe 2018 Dec 5. Epub 2018 Dec 5.

Augenklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55116, Mainz, Deutschland.

The treatment of congenital glaucoma requires special expertise and often novel surgical approaches. The combined use of a XEN and a Baerveldt implant is an alternative to conventional tube implants and may be less harmful for long-term corneal endothelial damage. If this technique does not provide sufficient long-term control of intraorbital pressure (IOP), a direct implantation of the Baerveldt tube can be easily performed in a second intervention. Read More

View Article
December 2018

Increased sensitivity of microbiological testing of cornea organ culture medium by additional resin treatment.

BMJ Open Ophthalmol 2018 10;3(1):e000173. Epub 2018 Nov 10.

Institute for Transfusion Medicine, University Tissue Bank, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objective: This validation study investigates the treatment of cornea organ culture medium (Modified Eagle Medium, Biochrom GmbH, Berlin, Germany) with RESEP, a new medical device for antibiotics removal, before microbiological testing with BACTEC blood culture bottles.

Methods And Analysis: 10-100 colony forming units of and were inoculated in 9mL of cornea organ culture medium. In group A, the medium was withdrawn with RESEP and treated for 20 min at room temperature, and then inoculated in BACTEC Plus Aerobic/F/Anaerobic/F blood culture bottles. Read More

View Article
November 2018
3 Reads

Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux.

Biomed Res Int 2018 1;2018:7627329. Epub 2018 Nov 1.

GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India.

Dry eye disease (DED) is a multifactorial ocular surface disorder affecting millions of individuals worldwide. Inflammation has been associated with dry eye and anti-inflammatory drugs are now being targeted as the alternate therapeutic approach for dry eye condition. In this study, we have explored the anti-inflammatory and autophagy modulating effect of chloroquine (CQ) in human corneal epithelial and human corneal fibroblasts cells exposed to desiccation stress, (an model for DED). Read More

View Article
November 2018

Diagnosis, Clinical Trend, and Treatment of Diffuse Lamellar Keratitis after Femtosecond Laser-Assisted in situ Keratomileusis: A Case Report.

Case Rep Ophthalmol 2018 Sep-Dec;9(3):457-464. Epub 2018 Nov 14.

Balestrazzi Associated Ophthalmological Practice, Rome, Italy.

We report a severe case of diffuse lamellar keratitis (DLK) following femtosecond laser-assisted in situ keratomileusis (femto-LASIK). A 25-year-old man was submitted to 150 kHz iFS® IntraLase-assisted LASIK in both eyes for compound myopic astigmatism. The day after surgery, clinical examination showed a diffuse whitish granular cell reaction particularly in the right eye. Read More

View Article
November 2018
5 Reads

"PI-less DMEK": results of Descemet's membrane endothelial keratoplasty (DMEK) without a peripheral iridotomy.

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To assess Descemet's membrane endothelial keratoplasty (DMEK) without performing a peripheral iridotomy (PI) prior to or during surgery ("PI-less DMEK").

Materials And Methods: This retrospective study included consecutive patients that underwent PI-less DMEK by a single surgeon (E.L) between February 2016 and February 2017 at the Rabin Medical Center, a Tertiary Hospital. Read More

View Article
December 2018
2 Reads

Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity.

Sci Rep 2018 Dec 5;8(1):17654. Epub 2018 Dec 5.

Molecular Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, 20892, USA.

Angiogenesis is crucial for tissue development and homeostasis; however, excessive angiogenesis can lead to diseases, including arthritis and cancer metastasis. Some antiangiogenic drugs are available, but side effects remain problematic. Thus, alternative angiogenesis inhibition strategies are needed. Read More

View Article
December 2018

Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.

EMBO J 2018 Dec 5. Epub 2018 Dec 5.

Institute of Metabolic Physiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

Vascular endothelial growth factor receptor-3 (VEGFR3) signalling promotes lymphangiogenesis. While there are many reported mechanisms of VEGFR3 activation, there is little understanding of how VEGFR3 signalling is attenuated to prevent lymphatic vascular overgrowth and ensure proper lymph vessel development. Here, we show that endothelial cell-specific depletion of integrin-linked kinase (ILK) in mouse embryos hyper-activates VEGFR3 signalling and leads to overgrowth of the jugular lymph sacs/primordial thoracic ducts, oedema and embryonic lethality. Read More

View Article
December 2018

Regulation of Oxidative Stress in Corneal Endothelial Cells by Prdx6.

Antioxidants (Basel) 2018 Dec 4;7(12). Epub 2018 Dec 4.

Tissue Engineering and Stem Cell group, Singapore Eye Research Institute (SERI), Singapore 169856, Singapore.

The inner layer of the cornea, the corneal endothelium, is post-mitotic and unable to regenerate if damaged. The corneal endothelium is one of the most transplanted tissues in the body. Fuchs' endothelial corneal dystrophy (FECD) is the leading indication for corneal endothelial transplantation. Read More

View Article
December 2018
1 Read

Is Sjögren's syndrome dry eye similar to dry eye caused by other etiologies? Discriminating different diseases by dry eye tests.

PLoS One 2018 3;13(12):e0208420. Epub 2018 Dec 3.

Department of Ophthalmology, Otorhinolaryngology and Head & Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Purpose: Dry Eye Disease (DED) is part of several conditions, including Sjögren's syndrome (SS) and no single test to diagnosis DED. The present study intends to evaluate whether a set of signs and symptoms of DED can distinguish: a) SS from other non-overlapping systemic diseases related to DED; b) primary and secondary SS.

Methods: 182 consecutive patients with DED were evaluated under five groups: SS, graft-versus-host disease (GVHD), Graves' orbitopathy (GO), diabetes mellitus (DM), glaucoma under treatment with benzalkonium chloride medications (BAK). Read More

View Article
December 2018

Corneal endothelial cell loss associated to phacoemulsification and ophthalmologist experience: prospective analysis of individual secondary data.

Medwave 2018 Oct 29;18(6):e7314. Epub 2018 Oct 29.

Centro Interdisciplinario de Estudios en Salud (CIESAL), Universidad de Valparaíso, Chile.

Introduction: Phacoeresis is the procedure through which the lens is surgically removed to treat cataracts. A corneal endothelial loss is a recognized sequel. Although several factors associated with this harm have been described, the surgeon’s prior experience has been scarcely evaluated. Read More

View Article
October 2018

Finding a very rare mutation in non-Caucasian LCAT patients from Southwest Asia for the first time.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Genetic laboratory of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran.

Introduction: Lecithin cholesterol acyltransferase (LCAT) deficiency is an autosomal recessive disorder occurred by different mutations in the LCAT gene that cause two extremely rare syndromes including familial LCAT deficiency (FLD) and fish-eye disease (FED). Unlike FED in FLD renal failure is the most important defect due to deposition of abnormal lipoproteins in the renal stroma. In this study, FLD patients from the North of Iran were investigated for mutations in the LCAT gene. Read More

View Article
December 2018

A presentation of culture-positive corneal donors and the effect on clinical outcomes.

Graefes Arch Clin Exp Ophthalmol 2018 Nov 30. Epub 2018 Nov 30.

Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.

Purpose: Donor-to-host transmission of infectious agents is a rare but well-recognised complication of corneal transplantation and may carry a grave visual prognosis. In this case series, we describe the clinical features and risk factors of using culture-positive donor corneas for transplantation.

Methods: Retrospective chart review of a series of patients who underwent either penetrating keratoplasty (PK) or Descemet's stripping automated endothelial keratoplasty (DSAEK) with positive microbiology cultivation during routine assessment of donor corneal tissue obtained at the time of surgery. Read More

View Article
November 2018

Bilateral combined anterior and posterior lenticonus in Alport's Syndrome.

Rom J Ophthalmol 2018 Jul-Sep;62(3):228-230

Department of Ophthalmology, Gajra Raja Medical College, Gwalior, India.

Alport's syndrome is an inherited disease characterized by hearing loss, progressive renal failure and ocular abnormalities like anterior lenticonus, corneal opacities, cataract, fleck retinopathies, and temporal retinal thinning. To have anterior and posterior lenticonus in the same eye in this syndrome is a rare finding and only a few such reports are available. Hereby, we report a case of a 22-year-old male with bilateral combined anterior and posterior lenticonus with sensorineural deafness and nephritis leading to the diagnosis of Alport's syndrome. Read More

View Article
December 2018

Investigation of importance of the structural parameters of the eyeball and of the technical parameters of cataract surgery on corneal endothelial changes.

Rom J Ophthalmol 2018 Jul-Sep;62(3):203-211

Anatomy Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

was to look into the importance of the structural parameters of the eyeball, in relationship with the technical parameters of cataract surgery regarding the corneal endothelial changes made by it. The paper refers at a prospective study in which we included eighty-eight consecutive eyes from eighty-six different patients having age-related cataract and a visual acuity of a values less than 0.8 considering best possible correction with it. Read More

View Article
December 2018

Ocular structures in a mature ovarian teratoma.

Am J Ophthalmol Case Rep 2019 Mar 8;13:20-21. Epub 2018 Nov 8.

Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA.

View Article

Exposure, entropion, and bilateral corneal ulceration in a newborn as a manifestation of chromosome 22 q11.2 duplication syndrome.

Am J Ophthalmol Case Rep 2019 Mar 4;13:16-19. Epub 2018 Nov 4.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Purpose: Chromosome 22q11.2 micro-duplication syndrome (MDS), is a rare autosomal dominant condition, with a highly variable phenotype that ranges from unremarkable and asymptomatic, to fatal due to cardiovascular defects. Hypertelorism, downslanting palpebral fissures, superior displacement of the eyebrows, and ptosis are the most commonly reported ocular manifestations. Read More

View Article

Adult conjunctivitis secondary to dual infection with and - A case report.

Am J Ophthalmol Case Rep 2019 Mar 14;13:6-8. Epub 2018 Nov 14.

Manchester Royal Eye Hospital, Oxford Road, Manchester, M13 9WL, UK.

Purpose: Although and are the commonest sexually transmitted infections in England, reports of ocular co-infection in the literature are limited. We report such a case which responded well to treatment, and discuss the literature and evidence currently available with regards to management of these cases.

Observations: The patient is a 48-year-old bisexual gentleman who presented to the eye clinic of a UK hospital with redness, discharge and blurred vision in his left eye for one week. Read More

View Article

Combined flanged intrascleral intraocular lens fixation with corneal transplant.

Am J Ophthalmol Case Rep 2019 Mar 10;13:1-5. Epub 2018 Nov 10.

Medical University of South Carolina, USA.

Purpose: To report clinical outcomes and surgical technique of flanged intrascleral intraocular lens fixation with double-needle combined with either penetrating keratoplasty (PKP) or ultrathin Descemet-stripping automated endothelial keratoplasty (UT-DSAEK).

Observations: Five patients underwent combined flanged intrascleral intraocular lens fixation with double-needle technique and keratoplasty. Three patients underwent triple procedure (open sky intrascleral intraocular lens fixation with double-needle and PKP) secondary to ocular trauma or a failed corneal transplant. Read More

View Article
March 2019
1 Read

Optical Rehabilitation of a Patient with Keratoconus and Nystagmus.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):183-189

Kentucky College of Optometry, University of Pikeville, Pikeville, KY, USA.

Keratoconus is a progressive corneal disease characterized by bilateral yet usually asymmetric thinning of the cornea with an onset typically in teenage years. While it often presents as an isolated condition, keratoconus may also be associated with many systemic and/or ocular diseases, such as connective tissue and chromosomal disorders. Its association with nystagmus has been described in Leber's congenital amaurosis, where patients also exhibit abnormal pupillary responses, early-onset retinal dystrophy, mental developmental delays, and eventual blindness. Read More

View Article
January 2018
3 Reads

keratitis in a patient with neurotrophic keratopathy and severe neurosensory hypoacusis: Treatment with penetrating keratoplasty and amniotic membrane grafting.

Oman J Ophthalmol 2018 Sep-Dec;11(3):291-293

Department of Anatomic pathology, Hospital Provincial de Castellón, Castellón de la Plana, Castellón, Spain.

We describe a case of a man with neurotrophic keratitis of unknown ethiology, who developed a massive stromal melting during treatment of a persistent epithelial defect. A tectonic keratoplasty combined with amniotic membrane grafting was made. Host cornea specimen was analyzed, and Sphingomonas paucimobilis was isolated. Read More

View Article
December 2018

Clinical Profile of Omani Keratoconus Patients: An Experience from a tertiary referral centre in Muscat.

Oman J Ophthalmol 2018 Sep-Dec;11(3):259-264

Department of Ophthalmology, Al-Nahdha Hospital, Muscat, Oman.

Objective: To determine the demographics and associated clinical features of Omani keratoconus patients presenting to the Ministry of Defence Hospital (MODH) in Muscat.

Methods: This is a retrospective, descriptive study whereby the electronic medical records of all Omani keratoconus patients presenting to the MODH between January 2011 and December 2015 were reviewed. Demographic details, corrected distance visual acuity, refraction, corneal topography, pachymetry, and treatment received were all documented. Read More

View Article
December 2018

Treatment before macular grid in patients of diabetic macular edema.

Oman J Ophthalmol 2018 Sep-Dec;11(3):254-258

Department of Biostatistics, Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Aim: The aim of this study is to compare the efficacy of intravitreal bevacizumab and posterior subtenons triamcinolone acetate in the management of diffuse diabetic macular edema (DME) and to evaluate their efficacy as an adjunct to modified grid laser in management of DME.

Design: This was a prospective, randomized clinical trial of 30 patients.

Materials And Methods: A total of 30 patients attending the medical ophthalmology clinic at a tertiary care hospital were included in the study. Read More

View Article
December 2018

Impact of venting incision on graft detachment in Descemet stripping automated endothelial keratoplasty.

Oman J Ophthalmol 2018 Sep-Dec;11(3):237-240

Department of Vitreo-Retina, Shri Ganapati Netralaya, Jalna, Maharashtra, India.

Purpose: To evaluate the impact of venting incision on graft detachment in Descemet stripping automated endothelial keratoplasty (DSAEK).

Materials And Methods: Retrospective comparative study on DSAEK procedure performed with ( = 13) and without ( = 39) venting incision. Patients were treated with DSAEK for various causes of endothelial decompensation between February 2014 and April 2016. Read More

View Article
December 2018

Outcomes of pterygium surgery-glue versus autologous blood versus sutures for graft fixation-an analysis.

Oman J Ophthalmol 2018 Sep-Dec;11(3):227-231

Department of Cornea, The Eye Foundation Hospital, Coimbatore, Tamil Nadu, India.

Aim: The aim of this study is to compare the surgical outcomes of pterygium excision with conjunctival autograft using sutures, fibrin glue (tisseel), and autologous blood for the management of primary pterygium.

Patients And Methods: A retrospective study done in 681 eyes with primary nasal pterygium. Excision of the pterygium was performed followed by closure of the bare sclera with conjunctival autograft using interrupted 10-0 monofilament nylon sutures in 173 eyes (Group 1), fibrin glue (tisseel-baxter healthcare corporation, westlake village, ca-91362 USA) in 351 eyes (Group 2), and autologous blood in 157 eyes (Group 3). Read More

View Article
December 2018

Incidence and risk factors for postkeratoplasty glaucoma in tertiary care center, India.

Oman J Ophthalmol 2018 Sep-Dec;11(3):220-226

Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Jolly Grant, Dehradun, Uttarakhand, India.

Background: Glaucoma is the leading cause of blindness after penetrating keratoplasty (PK) and its early diagnosis and management is mandatory to salvage the graft.

Aims: This study aimed to evaluate the incidence and risk factors for post penetrating keratoplasty glaucoma (PKG).

Methods: Data of 155 eyes of 155 patients were reviewed retrospectively who underwent PK from March 2013 to February 2016. Read More

View Article
December 2018

The epidemiology of nonviral microbial keratitis in a tertiary care center in Muscat, Oman.

Oman J Ophthalmol 2018 Sep-Dec;11(3):213-219

Department of Ophthalmology, Al-Nahdah Hospital, Muscat, Oman.

Objective: The objective of this study is to describe the epidemiology, risk factors, etiology, and outcome of microbial keratitis in a tertiary care center in Muscat, Oman.

Methods: The electronic records of all patients diagnosed with keratitis or corneal ulcer between January 2013 and January 2016 in Al-Nahdha Hospital were retrospectively reviewed. Patients who presented with a corneal ulcer requiring admission and who underwent culture and sensitivity studies were included in the study. Read More

View Article
December 2018

Comparison of ultrasonic pachymetry and Fourier-domain optical coherence tomography for measurement of corneal thickness in dogs with and without corneal disease.

Vet J 2018 Dec 30;242:59-66. Epub 2018 Oct 30.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA; Department of Ophthalmology & Vision Science, School of Medicine, University of California, Davis, 4610 X St., Sacramento, CA 95817, USA.

Several ultrasonic and Fourier-domain optical coherence tomography (FD-OCT) pachymeters are used to measure corneal thickness in canine patients and research subjects. This study assessed the reliability of and consistency between two ultrasonic pachymetry (USP) devices, Pachette 3 and Accupach VI, as well as automated and manual measurements obtained using FD-OCT in dogs with and without corneal disease. Corneal thickness measurements were compiled from 108 dogs and analyzed using mixed effects linear regression, with Bonferonni adjustments for post-hoc comparisons, to determine the effects of age, weight and disease state. Read More

View Article
December 2018

New trends in corneal transplants at the University of Toronto.

Can J Ophthalmol 2018 Dec 9;53(6):580-587. Epub 2018 May 9.

Keenan Research Centre at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ont; Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ont; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ont; Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.. Electronic address:

Objective: To assess trends in surgical procedures and indications for all corneal transplants performed at the University of Toronto.

Design: Retrospective cross-sectional study.

Participants: One thousand one hundred and four consecutive corneal transplants performed at the Kensington Eye Institute (KEI). Read More

View Article
December 2018

Iatrogenic limbal stem cell deficiency following drainage surgery for glaucoma.

Can J Ophthalmol 2018 Dec 2;53(6):574-579. Epub 2018 Apr 2.

Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom. Electronic address:

Objective: To describe conjunctival epithelial overgrowth of the cornea after surgery for glaucoma.

Methods: This is a retrospective case series (setting: Moorfields Eye Hospital). Fourteen eyes of 13 patients with suspected limbal stem cell deficiency (LSCD) and corneal conjunctivalization after glaucoma drainage surgery. Read More

View Article
December 2018

Analysis of penetrating keratoplasty in Northern Alberta, Canada, from 2000 to 2015.

Can J Ophthalmol 2018 Dec 10;53(6):568-573. Epub 2018 Apr 10.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address:

Objective: To study indications for penetrating keratoplasty (PK) at a single site. The trends in the causative organisms for infectious keratitis requiring surgery were also evaluated.

Design: Retrospective observational study. Read More

View Article
December 2018

Superficial keratectomy: indications and outcomes.

Can J Ophthalmol 2018 Dec 4;53(6):553-559. Epub 2018 Apr 4.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ont.. Electronic address:

Introduction: To evaluate the indications and outcomes of manual blade superficial keratectomy STUDY DESIGN: Retrospective, nonrandomized, consecutive case series METHODS: Database search of patients from 2012-2017 who underwent superficial keratectomy was conducted at a tertiary care hospital cornea clinic. Charts of 121 patients (156 eyes) were reviewed who had at least 4 weeks of follow-up and both preoperative and postoperative measurements of best-corrected visual acuity or corneal cylinder. Outcome measures included: patient demographics, surgical indication, prior ocular history, best-corrected visual acuity (BCVA) changes, corneal and refractive astigmatism changes, recurrence of pathology, additional treatments required, and intraoperative and postoperative complications. Read More

View Article
December 2018

Corneal structure, transparency, thickness and optical density (densitometry), especially as relevant to contact lens wear-a review.

Cont Lens Anterior Eye 2018 Nov 28. Epub 2018 Nov 28.

Department of Vision Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, United Kingdom. Electronic address:

Clinical instruments using Scheimpflug image-based methods to obtain optical sectional images of the cornea have been introduced in recent years along with proposals that it should be possible to routinely and reliably measure the optical density (referred to as the densitometry) of the human cornea in situ. Such a concept is reviewed from the perspective of what might be considered as the basic principles underlying the understanding of corneal transparency (from the 1950's) and the progressive changes in these ideas from subjective slitlamp-based clinical observations from the late 1960's, especially in contact lens wearers. Much more has been learned about the overall macrostructure (including corneal thickness) and the ultrastructure of the cornea from contemporary studies in the 1990's, and these aspects of the cornea will be reviewed alongside consideration of the methods of assessing the optical characteristics of the cornea in the living eye. Read More

View Article
November 2018

Clinical outcomes of Descemet membrane endothelial keratoplasty in eyes with a glaucoma drainage device.

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Netherlands Institute for Innovative Ocular Surgery (NIIOS), Rotterdam, The Netherlands; Melles Cornea Clinic Rotterdam, The Netherlands; Amnitrans Eye Bank Rotterdam, The Netherlands; NIIOS-USA, San Diego, USA. Electronic address:

Purpose: To evaluate the feasibility and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with a glaucoma drainage device (GDD).

Design: Retrospective, interventional case series.

Methods: Clinical outcomes of 23 DMEK procedures for bullous keratopathy (52%), failed previous transplant (39%) or Fuchs endothelial corneal dystrophy (9%) in 20 eyes (19 patients) with a GDD were retrospectively analyzed at two tertiary referral centers. Read More

View Article
November 2018

Determination of central corneal clearance in scleral lenses with an optical biometer and agreement with subjective evaluation.

Cont Lens Anterior Eye 2018 Nov 27. Epub 2018 Nov 27.

Clinical & Experimental Optometry Research Lab (CEORLab), Center of Physics. University of Minho, Braga, Portugal.

Purpose: To compare three methods to measure center corneal clearance (CCC) during scleral lens wear: subjective (slit lamp), image processed (ImageJ) and with an optic biometer. The optic biometer technique was validated in comparison to an OCT in the first part of the study.

Methods: Twenty-two eyes (11 subjects) with healthy corneas were recruited. Read More

View Article
November 2018

Automated 2D-3D quantitative analysis of corneal graft detachment post DSAEK based on AS-OCT images.

Comput Methods Programs Biomed 2018 Dec 9;167:1-12. Epub 2018 Oct 9.

Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana 500034, India.

Background And Objective: In current ophthalmological practices, assessment of graft condition post Descemet's stripping automated endothelial keratoplasty (DSAEK) is performed qualitatively using few (four) anterior-segment optical coherence tomography (AS-OCT) radial B-scans. From those scans, clinicians need to mentally synthesize the graft in 3D, and estimate its overall condition. In contrast, quantitative representation of 360° thickness profile would facilitate better visualization of graft condition, and hence medical decision making. Read More

View Article
December 2018

Retinal Nerve Fiber Layer Thickness Changes after Phacoemulsification with Intraocular Lens Implantation.

J Coll Physicians Surg Pak 2018 Dec;28(12):919-922

Department of Ophthalmology, Mayo Hospital, Lahore, Pakistan.

Objective: To determine the changes in the retinal nerve fiber layer as measured on optical coherence tomography (OCT) after phacoemulsification with intraocular lens implantation.

Study Design: Quasi-experimental study.

Place And Duration Of Study: Department of Ophthalmology, Lahore General Hospital, Lahore, from March 2017 to April 2018. Read More

View Article
December 2018

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5752-5761

University of Houston College of Optometry, Houston, Texas, United States.

Purpose: The purpose of this study was to explore differences in genotype, ocular surface microbiome, tear inflammatory markers, and environmental and behavioral exposures in soft contact lens (SCL) wearers with and without a history of corneal infiltrative events (CIEs).

Methods: Nine SCL wearers with a recent CIE and nine age-, sex-, and SCL material- and modality-matched controls were enrolled. The Contact Lens Risk Survey, slit-lamp examination data, basal tears, conjunctival microbial cultures, and peripheral blood samples were collected. Read More

View Article
December 2018
6 Reads

Topical Rho-Associated Kinase Inhibitor, Y27632, Accelerates Corneal Endothelial Regeneration in a Canine Cryoinjury Model.

Cornea 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA.

Purpose: Corneal endothelial cell regeneration varies by species, with nonhuman primates (NHPs) and rabbits displaying low and high proliferative capacities, respectively. Recent studies report that topical application of rho-associated kinase (ROCK) inhibitors accelerates corneal endothelial wound healing in animal models and human patients with endothelial dysfunction. This study determines the regenerative capacity of canine corneal endothelial cells in vivo and their response to a topical ROCK inhibitor, Y27632, after transcorneal freezing. Read More

View Article
November 2018
1 Read

Inhibition of microRNA-129-5p expression ameliorates ultraviolet ray-induced corneal epithelial cell injury via upregulation of EGFR.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Ophthalmology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.

Existing evidence has highlighted the effect of ultraviolet light radiation leading to corneal epithelium impairment. During this study, we aim to investigate the effect of microRNA-129-5p (miR-129-5p) on the wound healing process of corneal epithelial cells (CECs) induced by ultraviolet rays in mice by targeting epidermal growth factor receptor (EGFR). First, mouse models of ultraviolet ray-induced CEC injury were established and intrastromally injected with different mimic, inhibitor, and short interfering RNA (siRNA) to detect the effect of miR-129-5p on CEC injury. Read More

View Article
December 2018

Visual Outcomes of Ultrathin-Descemet Stripping Endothelial Keratoplasty versus Descemet Stripping Endothelial Keratoplasty.

J Ophthalmol 2018 1;2018:5924058. Epub 2018 Nov 1.

First Department of Ophthalmology, National and Kapodistrian University of Athens, General Hospital "G. Gennimatas", Athens, Greece.

Purpose: To examine the impact of graft thickness (GT) on postoperative visual acuity and endothelial cell density after ultrathin-Descemet stripping automated endothelial keratoplasty (UT-DSAEK) versus conventional DSAEK.

Methods: The medical records of all patients who underwent DSAEK at our institute during a 2-year period were reviewed. After excluding subjects with low visual potential, 34 eyes were divided into two groups based on the postoperative GT as measured with anterior segment optical coherence tomography (AS-OCT): an UT-DSAEK group (GT ≤ 100 m, =13 eyes) and a DSAEK group (GT > 100 m, =21 eyes). Read More

View Article
November 2018

Corneal Epithelial Damage and Impaired Tear Functions in Patients with Inflamed Pinguecula.

J Ophthalmol 2018 31;2018:2474173. Epub 2018 Oct 31.

Ophthalmology Department, Niğde Ömer Halisdemir University, Faculty of Medicine, 51240 Niğde, Turkey.

Purpose: In this study, we evaluated corneal epithelial integrity and tear film parameters in patients with inflamed pinguecula and compared these findings with their fellow eyes and with healthy controls.

Methods: We evaluated the fluorescein staining properties and performed the tear break-up time (TBUT) test and Schirmer 2 test (ST2) measurements of 32 patients who had symptomatic unilateral inflamed pinguecula and compared the results with their fellow eyes and also with an age- and sex-matched control group.

Results: Twenty-three eyes (72%) in the inflamed pinguecula group and 1 eye (3. Read More

View Article
October 2018
2 Reads

Eye care in the intensive care unit.

J Intensive Care Soc 2018 Nov 22;19(4):345-350. Epub 2018 Mar 22.

University College London/Institute of Ophthalmology and Moorfields Eye Hospital, London, UK.

Ocular surface disease is common in the intensive care population with 20-42% of patients developing corneal epithelial defects. The ocular surface is normally protected by the ability to produce tears, to blink and to close the eyes with rest or sleep. All of these mechanisms can be disrupted in the intensive care population, increasing the risk of developing ocular surface disease. Read More

View Article
November 2018
2 Reads

Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation.

Front Immunol 2018 20;9:2666. Epub 2018 Nov 20.

Regenerative Medicine Institute, School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. In this study, a rat model of pre-existing anti-donor immunity was developed in which corneal allografts were rejected earlier than in non-pre-sensitized recipients. In this model, third-party (non-donor, non-recipient strain) allogeneic mesenchymal stromal cells (allo-MSC) were administered intravenously 7 and 1 days prior to transplantation. Read More

View Article
November 2018

Evaluation of the corneal epithelium in non-Sjögren's and Sjögren's dry eyes: an in vivo confocal microscopy study using HRT III RCM.

BMC Ophthalmol 2018 Dec 4;18(1):309. Epub 2018 Dec 4.

Doheny Image Reading Center, Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA, 90033, USA.

Background: The corneal epithelium is directly affected in dry eye syndrome. Thus, we attempted to describe the morphological features and evaluate the cellular density within the corneal epithelial layers in patients with non-Sjögren's (NSDE) and Sjögren's syndrome dry eyes (SSDE) by in vivo confocal microscopy (IVCM).

Methods: Central cornea was prospectively imaged by IVCM in 68 clinically diagnosed aqueous tear-deficient dry eyes and 10 healthy age-matched control eyes. Read More

View Article
December 2018

High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element Transducer.

Sensors (Basel) 2018 Dec 3;18(12). Epub 2018 Dec 3.

Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.

Estimating the corneal elasticity can provide valuable information for corneal pathologies and treatments. Ophthalmologic pathologies will invariably cause changes to the elasticity of the cornea. For example, keratoconus and the phototoxic effects of ultraviolet radiation usually increase the corneal elasticity. Read More

View Article
December 2018

Investigation of Combined Cyclodextrin and Hydrogel Formulation for Ocular Delivery of Dexamethasone Acetate by Means of Experimental Designs.

Pharmaceutics 2018 Dec 1;10(4). Epub 2018 Dec 1.

Faculty of Pharmacy, University of Grenoble Alpes, DPM, UMR CNRS 5063, ICMG FR 2607, F-38400 Saint Martin d'Hères, France.

Dexamethasone acetate (DXMa) has proven its efficiency to treat corneal inflammation, without a great propensity to increase intraocular pressure. Unfortunately, its poor aqueous solubility, associated with a rapid precorneal elimination, results in a low drug bioavailability and a low penetration after topical ocular administration. The main objective of this study was to improve the apparent aqueous solubility of DXMa using cyclodextrins. Read More

View Article
December 2018
2 Reads

Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA.

Decreased corneal innervation is frequent in patients with Sjögren Syndrome (SS). To investigate the density and morphology of the intraepithelial corneal nerves (ICNs), corneal sensitivity, epithelial cell proliferation, and changes in mRNA expression of genes that are involved in autophagy and axon targeting and extension were assessed using the IL-2 receptor alpha chain (CD25 null) model of SS. ICN density and thickness in male and female wt and CD25 null corneas were assessed at 4, 6, 8, and 10/11 wk of age. Read More

View Article
November 2018