3,192 results match your criteria Corneal Graft Rejection


Effect of keratoconus severity on clinical outcomes after deep anterior lamellar keratoplasty.

Am J Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the effect of keratoconus severity on the visual and refractive outcomes and complications after deep anterior lamellar keratoplasty (DALK).

Design: Consecutive interventional case series.

Methods: This study enrolled 227 keratoconus-affected eyes that underwent DALK. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.030DOI Listing
February 2019
1 Read

Histopathology of a retrocorneal membrane after Descemet membrane endothelial keratoplasty: a case report.

J Med Case Rep 2019 Feb 6;13(1):31. Epub 2019 Feb 6.

Department of Ophthalmology, University Hospital of Tübingen, Elfriede-Aulhorn-Str. 7, 72076, Tübingen, Germany.

Background: We report the first histopathologically proven occurrence of a retrocorneal membrane after Descemet's membrane endothelial keratoplasty.

Case Presentation: A white Caucasian 76-year-old woman received penetrating keratoplasty on her right eye 2 years after Descemet's membrane endothelial keratoplasty surgery with combined cataract extraction and intraocular lens implantation for Fuchs' endothelial corneal dystrophy due to an allograft rejection with ensuing graft failure. Her preoperative vision was counting fingers (20/2000) caused by immunological debris, corneal edema, and secondary membrane formation. Read More

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http://dx.doi.org/10.1186/s13256-018-1960-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364459PMC
February 2019
4 Reads

A case of recurrent keratitis caused by Paecilomyces lilacinus and treated by voriconazole.

Arq Bras Oftalmol 2019 Mar-Apr;82(2):152-154

Department of Ophthalmology and Visual Sciences, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

We describe here a case of a 21-year-old woman who presented with low visual acuity, pain, and hyperemia in the left eye for 45 days. Her eye had extensive corneal infiltrate, with melting and a central perforation that was glued with cyanoacrylate, but with Seidel (+). She underwent tectonic corneal transplantation, and anterior chamber lavage with subconjunctival infiltration with voriconazole, as well as intracameral injections of amphotericin B. Read More

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http://www.gnresearch.org/doi/10.5935/0004-2749.20190031
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http://dx.doi.org/10.5935/0004-2749.20190031DOI Listing
July 2018
2 Reads

Deep anterior lamellar keratoplasty for keratoconus: multi-surgeon results.

Am J Ophthalmol 2019 Feb 2. Epub 2019 Feb 2.

Department of Corneal and External Eye Diseases, Moorfields Eye Hospital, London EC1V 2PD, United Kingdom. Electronic address:

Purpose: To examine clinical outcomes in deep anterior lamellar keratoplasty (DALK) for keratoconus using contemporary techniques in a multi-surgeon public healthcare setting.

Design: Consecutive, retrospective case series.

Setting: Moorfields Eye Hospital, London STUDY POPULATION: Consecutive cases of keratoconus treated with non-laser assisted DALK from September 1, 2012, to September 31, 2016. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.022DOI Listing
February 2019
1 Read

Surgical Corneal Anatomy in Deep Anterior Lamellar Keratoplasty: Suggestion of New Acronyms.

Cornea 2019 Jan 23. Epub 2019 Jan 23.

Clinica degli Occhi Sarnicola, Grosseto, Italy.

Deep anterior lamellar keratoplasty (DALK) is the ideal surgery for corneal stromal diseases with a healthy endothelium. This technique offers substantial advantages compared with penetrating keratoplasty, primarily the avoidance of endothelial rejection and longer graft survival. Several DALK techniques have been described and classified into 2 categories, descemetic DALK (dDALK) and predescemetic DALK (pdDALK) depending on whether Descemet membrane-endothelium was thought to be exposed or minimal residual stroma was left behind. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001845DOI Listing
January 2019
1 Read

Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14191

Department of Ophthalmology and Visual Science, Daejeon St. Mary's Hospital.

Rationale: To report a case of herpes simplex virus (HSV) linear endotheliitis in a 57-year-old male who had underwent keratoplasty 10 years ago. The characteristic linear keratic precipitates (KPs) resembled the Khodadoust line in graft rejection. The differential diagnosis is essential, because the treatment regimen is different between HSV linear endotheliitis and graft rejection. Read More

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http://dx.doi.org/10.1097/MD.0000000000014191DOI Listing
January 2019
1 Read

Cytomegalovirus infection is not a major cause of corneal graft failure in the United Kingdom.

Eye (Lond) 2019 Jan 8. Epub 2019 Jan 8.

External Disease Service, Moorfields Eye Hospital, London, United Kingdom.

Background: Cytomegalovirus (CMV) endotheliitis is a significant cause for acute corneal allograft rejection in East Asian populations, where there is a high CMV seroprevalence. To determine how frequently CMV is associated with corneal graft failure in the UK, we looked for the presence of CMV DNA in grafts that had failed and had been removed at repeat keratoplasty. We also looked for CMV DNA in corneal rims discarded after corneal transplantation. Read More

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http://dx.doi.org/10.1038/s41433-018-0331-9DOI Listing
January 2019
2 Reads

A Multicenter Study Evaluating the Risk Factors and Outcomes of Repeat Descemet Stripping Endothelial Keratoplasty.

Cornea 2019 Feb;38(2):177-182

Department of Ophthalmology, Loyola University Medical Center, Maywood, IL.

Purpose: Descemet stripping endothelial keratoplasty (DSEK), currently the most common procedure for managing corneal endothelial dysfunction, may be repeated following DSEK failure from a variety of causes. This multicenter study reports the risk factors and outcomes of repeat DSEK.

Methods: This was an institutional review board-approved multicenter retrospective chart review of patients who underwent repeat DSEK. Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9667
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http://dx.doi.org/10.1097/ICO.0000000000001817DOI Listing
February 2019
6 Reads

Cytomegalovirus Corneal Endotheliitis After Descemet Membrane Endothelial Keratoplasty.

Cornea 2018 Dec 31. Epub 2018 Dec 31.

Corneal and External Eye Disease Department, Singapore National Eye Centre, Singapore.

Purpose: To describe 4 cases of cytomegalovirus (CMV) corneal endotheliitis occurring after Descemet membrane endothelial keratoplasty (DMEK).

Methods: This is a retrospective, interventional case series. Case records of 4 patients (one eye each) diagnosed with CMV corneal endotheliitis after DMEK were reviewed retrospectively. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001847DOI Listing
December 2018
9 Reads

Corneal endothelial cell dysfunction: etiologies and management.

Authors:
Sepehr Feizi

Ther Adv Ophthalmol 2018 Jan-Dec;10:2515841418815802. Epub 2018 Dec 7.

Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran 16666, Iran.

A transparent cornea is essential for the formation of a clear image on the retina. The human cornea is arranged into well-organized layers, and each layer plays a significant role in maintaining the transparency and viability of the tissue. The endothelium has both barrier and pump functions, which are important for the maintenance of corneal clarity. Read More

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http://dx.doi.org/10.1177/2515841418815802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293368PMC
December 2018
7 Reads

Comparison of endothelial/Descemet's membrane complex thickness with endothelial cell density for the diagnosis of corneal transplant rejection.

Ther Adv Ophthalmol 2018 Jan-Dec;10:2515841418814187. Epub 2018 Dec 3.

Department of Ophthalmology, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136, USA.

Purpose: This study compared the effectiveness of endothelial/Descemet's membrane complex thickness obtained using high-definition anterior segment optical coherence tomography with endothelial cell density obtained using confocal microscopy as diagnostic tools in predicting corneal transplant rejection.

Methods: This observational, prospective, cross-sectional study evaluated penetrating keratoplasty grafts. Slit lamp examination organized the grafts into healthy or rejecting grafts. Read More

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http://dx.doi.org/10.1177/2515841418814187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293363PMC
December 2018
1 Read

Graft rejection-like reactions in the early postoperative period after deep anterior lamellar keratoplasty for keratoconus: a retrospective study.

Clin Ophthalmol 2018 14;12:2315-2322. Epub 2018 Nov 14.

Department of Ophthalmology, Japan Community Health Care Organization Hoshigaoka Medical Center, Hirakata, Osaka 573-8511, Japan.

Background: Deep anterior lamellar keratoplasty (DALK) is indicated to correct high astigmatism in patients with keratoconus (KC) and no evidence of Descemet's membrane rupture. However, some patients with KC experience graft rejection-like inflammatory reactions within 2 months (usually in the first week) after DALK. The aim of this study was to identify the characteristics and influencing factors of these reactions by reviewing the records of patients who underwent DALK or penetrating keratoplasty (PKP) for KC or other corneal problems. Read More

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http://dx.doi.org/10.2147/OPTH.S178161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241761PMC
November 2018
1 Read

[Emphasizing the indications and perioperative management of artificial corneal transplantation].

Authors:
M C Zhang H T Xie

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):881-882

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

An artificial cornea is a lamellar porcine corneal implant. Artificial corneas may be beneficial for the shortage of cornea donors and eye banks. It is necessary to grasp the indications of artificial corneal transplantation and pay attention to its perioperative treatment to reduce relapse and rejection, so as to achieve the best postoperative effect. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.12.001DOI Listing
December 2018
1 Read

Clinical outcomes of Descemet membrane endothelial keratoplasty in eyes with a glaucoma drainage device.

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Netherlands Institute for Innovative Ocular Surgery (NIIOS), Rotterdam, The Netherlands; Melles Cornea Clinic Rotterdam, The Netherlands; Amnitrans Eye Bank Rotterdam, The Netherlands; NIIOS-USA, San Diego, USA. Electronic address:

Purpose: To evaluate the feasibility and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with a glaucoma drainage device (GDD).

Design: Retrospective, interventional case series.

Methods: Clinical outcomes of 23 DMEK procedures for bullous keratopathy (52%), failed previous transplant (39%) or Fuchs endothelial corneal dystrophy (9%) in 20 eyes (19 patients) with a GDD were retrospectively analyzed at two tertiary referral centers. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.11.014DOI Listing
November 2018
3 Reads

Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation.

Front Immunol 2018 20;9:2666. Epub 2018 Nov 20.

Regenerative Medicine Institute, School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. In this study, a rat model of pre-existing anti-donor immunity was developed in which corneal allografts were rejected earlier than in non-pre-sensitized recipients. In this model, third-party (non-donor, non-recipient strain) allogeneic mesenchymal stromal cells (allo-MSC) were administered intravenously 7 and 1 days prior to transplantation. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255848PMC
November 2018
1 Read

Single-piece femtosecond-assisted mushroom keratoplasty in children.

J AAPOS 2018 Nov 27. Epub 2018 Nov 27.

Royal Victorian Eye and Ear Hospital, Melbourne, Australia.

Purpose: To report outcomes of femtosecond-assisted single-piece mushroom keratoplasty for the treatment of full-thickness corneal disease in pediatric patients with healthy endothelium.

Methods: Femtosecond-assisted mushroom keratoplasty was performed in 8 eyes of 8 patients (age range, 8-17 years) with central full-thickness corneal opacity. The single-piece mushroom-shaped graft consisted of a large anterior portion (9 mm in diameter; 250 μm in thickness) and a small posterior portion (6-6. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10918531183059
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http://dx.doi.org/10.1016/j.jaapos.2018.08.009DOI Listing
November 2018
20 Reads

Association of Iris Damage With Reduction in Corneal Endothelial Cell Density After Penetrating Keratoplasty.

Cornea 2019 Mar;38(3):268-274

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.

Purpose: To evaluate the effect of iris damage on endothelial cell loss in the early phase after penetrating keratoplasty (PKP).

Methods: This prospective consecutive study included 74 patients who underwent PKP without graft rejection during the follow-up period. Endothelial cell density (ECD) was measured using specular microscopy at 1, 3, 6, and 12 months after PKP. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001819DOI Listing
March 2019
2 Reads

The Effect of Donor- and Recipient-Related Factors on Corneal Graft Survival in Penetrating Keratoplasty.

Semin Ophthalmol 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Department of Ophthalmology , Bozyaka Training and Research Hospital , İzmir , Turkey.

Purpose: To investigate the impact of donor and recipient factors on graft survival in penetrating keratoplasty (PK).

Material And Methods: This retrospective study included 365 eyes that underwent PK using corneas from 231 donors between June 2010 and June 2015. Patients were divided into three groups (group 1: primary endothelial diseases; group 2: iatrogenic endothelial disorders; and group 3: other pathologies with a healthy endothelium) according to PK indications. Read More

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http://dx.doi.org/10.1080/08820538.2018.1549681DOI Listing
November 2018
2 Reads

Evaluation of Big Bubble Technique for Deep Anterior Lamellar Keratoplasty in Patients With Radial Keratotomy.

Cornea 2019 Feb;38(2):194-197

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.

Purpose: To report the outcome of deep anterior lamellar keratoplasty (DALK) and success rates of the big-bubble (BB) technique or manual dissection after a failed use of the BB technique in eyes that underwent prior radial keratotomy (RK).

Methods: A retrospective chart review of patients who underwent DALK after RK at Toronto Western Hospital, Canada, between 1999 and 2017 was performed. Demographic characteristics, success rates of the BB technique and manual dissection, intraoperative and postoperative complications, and best spectacle-corrected visual acuity before and after corneal transplant were analyzed. Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9667
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http://dx.doi.org/10.1097/ICO.0000000000001811DOI Listing
February 2019
15 Reads

Comparison of Small-incision Femtosecond Laser-assisted Intrastromal Keratoplasty and Lamellar Keratoplasty in Rhesus Monkeys Using Xenogenic Corneal Lamellae.

Curr Mol Med 2018 ;18(6):365-375

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University. Guangzhou 510060, China.

Background: In our previous study, both allogeneic and xenogeneic smallincision femtosecond laser-assisted intrastromal keratoplasty were demonstrated to be safe and effective surgeries. Glycerol-dehydrated corneal lamellae could serve as alternative xenogeneic inlay grafts. However, these xenogeneic lamellae have not been explored in lamellar keratoplasty (LK). Read More

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http://www.eurekaselect.com/167201/article
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http://dx.doi.org/10.2174/1566524018666181109120023DOI Listing
January 2018
18 Reads
3.620 Impact Factor

Incidence and Outcomes of Intraoperative Descemet Membrane Perforations During Deep Anterior Lamellar Keratoplasty.

Am J Ophthalmol 2018 Oct 31. Epub 2018 Oct 31.

Singapore National Eye Centre, Singapore; Singapore Eye Research Institute, Singapore; Ophthalmology Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Purpose: To report the incidence and outcomes of intraoperative Descemet membrane (DM) perforations during deep anterior lamellar keratoplasty (DALK).

Design: Retrospective, consecutive, interventional case series.

Methods: A retrospective audit of all DALK cases performed from 2004 to 2015 in a tertiary centre, with and without intraoperative DM perforations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183062
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http://dx.doi.org/10.1016/j.ajo.2018.10.026DOI Listing
October 2018
13 Reads

Semaphorin 3F Modulates Corneal Lymphangiogenesis and Promotes Corneal Graft Survival.

Invest Ophthalmol Vis Sci 2018 Oct;59(12):5277-5284

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Purpose: Corneal vascularization significantly increases the risk for graft rejection after keratoplasty. Semaphorin 3F (Sema3F) is a known modulator of physiologic avascularity in the outer retina. The aim of this study was to investigate whether Sema3F is involved in maintaining corneal avascularity and can reduce the risk for corneal graft rejection. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-24287DOI Listing
October 2018
8 Reads

Longitudinal changes in corneal leucocyte density in vivo following transplantation.

Br J Ophthalmol 2018 Oct 24. Epub 2018 Oct 24.

NIHR Moorfields Clinical Research Facility, Moorfields Eye Hospital, London, UK

Aims: To prospectively evaluate the changes in corneal leucocyte density with in vivo confocal microscopy (IVCM) following transplantation and to determine if leucocyte density post-transplant is an indicator of graft rejection risk.

Methods: IVCM imaging of cornea pre-transplant and post-transplant at 1  week, 1, 3 and 12 months. The changes in leucocyte density associated with diagnosis, vascularisation, type of keratoplasty, topical steroid and immunosuppression treatment, allograft rejection and failure within 4 years post-transplant were analysed. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312386DOI Listing
October 2018
2 Reads

Rapamycin Nano-Micelle Ophthalmic Solution Reduces Corneal Allograft Rejection by Potentiating Myeloid-Derived Suppressor Cells' Function.

Front Immunol 2018 8;9:2283. Epub 2018 Oct 8.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.

Allograft rejection is the major cause of corneal allograft failure. Rapamycin (RAPA) has been reported as an effective and novel immunosuppressive agent for patients undergoing corneal transplantation. However, its high water insolubility and low bioavailability have strongly constrained its clinical application. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186809PMC
October 2018
20 Reads

Influence of Intraoperative Air Tamponade Time on Graft Adherence in Descemet Membrane Endothelial Keratoplasty.

Cornea 2019 Feb;38(2):166-172

Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.

Purpose: To study the influence of different intraoperative air tamponade times on graft adherence after Descemet membrane endothelial keratoplasty (DMEK).

Methods: In this interventional case series, we evaluated 117 eyes with Fuchs endothelial corneal dystrophy (FECD) that underwent DMEK using intraoperative air tamponade times of 60 minutes (group I; n = 39), 45 minutes (group II; n = 39), or 30 minutes (group III; n = 39). At 1 and 6 months postoperatively, graft adherence status, endothelial cell density, central pachymetry, and postoperative complications were recorded. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001795DOI Listing
February 2019
10 Reads

Postoperative Repositioning of Inverted Descemet Membrane Endothelial Keratoplasty Grafts.

Cornea 2019 Feb;38(2):162-165

Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.

Purpose: To present 4 cases of postoperative repositioning of inverted grafts after Descemet membrane endothelial keratoplasty (DMEK).

Methods: Retrospective case reports of 4 patients presenting with subtotal to total graft detachment after DMEK, most probably owing to upside-down graft positioning. Graft repositioning was performed 1 to 14 days after initial DMEK surgery. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001796DOI Listing
February 2019

Outcomes of the first 250 eyes of Descemet membrane endothelial keratoplasty: Canadian centre experience.

Can J Ophthalmol 2018 Oct 7;53(5):510-517. Epub 2018 May 7.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ont.

Objective: To report and analyze the clinical outcomes of the first 250 cases of Descemet membrane endothelial keratoplasty (DMEK).

Methods: A retrospective case series was conducted on the first 250 DMEK cases. The cohort included eyes with previous trabeculectomy, pre-existing glaucoma drainage device, and previous vitrectomy. Read More

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http://dx.doi.org/10.1016/j.jcjo.2017.11.017DOI Listing
October 2018
4 Reads

Descemet Membrane Endothelial Keratoplasty (DMEK) Graft Dislocation Into the Vitreous Cavity.

Cornea 2019 Feb;38(2):173-176

Vitreo-Retinal Service, Moorfields Eye Hospital, London, United Kingdom.

Purpose: To present our experience of Descemet stripping endothelial keratoplasty (DMEK) graft luxation into the vitreous cavity in 2 cases.

Methods: DMEK was performed in 2 patients with aphakic bullous keratopathy. The indications for keratoplasty were endothelial failure caused by chronic intermediate uveitis and glaucoma in 1 case and decompensated previous penetrating keratoplasty in the other. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001788DOI Listing
February 2019
3 Reads

Using Deep Learning in Automated Detection of Graft Detachment in Descemet Membrane Endothelial Keratoplasty: A Pilot Study.

Cornea 2019 Feb;38(2):157-161

Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.

Purpose: To evaluate a deep learning-based method to automatically detect graft detachment (GD) after Descemet membrane endothelial keratoplasty (DMEK) in anterior segment optical coherence tomography (AS-OCT).

Methods: In this study, a total of 1172 AS-OCT images (609: attached graft; 563: detached graft) were used to train and test a deep convolutional neural network to automatically detect GD after DMEK surgery in AS-OCT images. GD was defined as a not completely attached graft. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001776DOI Listing
February 2019
2 Reads

Stenciling-Based "Prick and Print" Technique for Harvesting Shaped Corneal Grafts for Management of Peripheral Corneal Perforations.

Cornea 2019 Jan;38(1):105-109

Department of Cornea and Refractive Services, Sadguru Seva Sang Trust, Chitrakoot, Madhya Pradesh, India.

Purpose: To evaluate a new surgical technique ("prick and print") for harvesting shaped donor corneal grafts in cases with perforated peripheral ulcerative keratitis (PUK).

Methods: We conducted a retrospective case series at a tertiary center. Medical records of 13 patients with perforated PUK, who underwent tectonic eccentric keratoplasty using the stenciling-based prick and print technique during the past 1 year, were reviewed. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001774DOI Listing
January 2019
3 Reads

Precut DMEK Using Dextran-Containing Storage Medium Is Equivalent to Conventional DMEK: A Prospective Pilot Study.

Cornea 2019 Jan;38(1):24-29

Department of Ophthalmology, Eye Clinic Sulzbach, Knappschaft Hospital Saar, Sulzbach/Saar, Germany.

Purpose: To compare the clinical outcome after Descemet membrane endothelial keratoplasty (DMEK) either as precut or conventional Descemet membrane graft preparation under standard European eye bank organ culture conditions.

Methods: This was a prospective pilot study of patients receiving either precut or conventional DMEK. Graft preparation was performed using the liquid bubble technique. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001778DOI Listing
January 2019
3 Reads

Long-Term Results of Femtosecond Laser-Enabled Keratoplasty With Zig-Zag Trephination.

Cornea 2019 Jan;38(1):42-49

Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, Irvine, CA.

Purpose: To report long-term visual and astigmatism outcomes in cases of zig-zag femtosecond laser-enabled penetrating keratoplasty (FLEK).

Methods: Retrospective review. Three hundred thirty-five eyes of 287 patients underwent (FLEK) with a zig-zag incision pattern. Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9671
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http://dx.doi.org/10.1097/ICO.0000000000001783DOI Listing
January 2019
2 Reads

Functional Staging of Corneal Neovascularization Using Fluorescein and Indocyanine Green Angiography.

Transl Vis Sci Technol 2018 Sep 1;7(5):15. Epub 2018 Oct 1.

Department of Ophthalmology, Medical University of Innsbruck, Innsbruck, Austria.

Purpose: Corneal neovascularization (CoNV) is a major risk factor for corneal graft rejection and other corneal conditions. The maturity of CoNV is important to guide treatment. This study investigated associations between clinical and angiographic characteristics of CoNV. Read More

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http://dx.doi.org/10.1167/tvst.7.5.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166904PMC
September 2018
2 Reads

Long-term safety outcome of systemic immunosuppression in pig-to-nonhuman primate corneal xenotransplantation.

Xenotransplantation 2018 07;25(4):e12442

Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.

Background: Safety concerns exist for corneal recipients under immunosuppression. We report long-term safety results of porcine corneal xenotransplantation under immunosuppression in nonhuman primates.

Methods: Systemic monitoring data from 49 Chinese rhesus macaques that received pig corneal transplant between 2009 and 2018 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1111/xen.12442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166667PMC
July 2018
4 Reads
2.840 Impact Factor

Elevation of preoperative recipient aqueous cytokine levels in eyes with primary graft failure after corneal transplantation.

Mol Vis 2018 13;24:613-620. Epub 2018 Sep 13.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.

Purpose: Primary graft failure after corneal transplantation is caused by dysfunction of corneal endothelial cells. Recently, we demonstrated that preoperative recipients' aqueous cytokine levels are associated with rapid corneal endothelial cell loss after corneal transplantation. In the present study, we evaluated the preoperative inflammatory cytokine levels in the aqueous humor (AqH) of eyes with primary graft failure following corneal transplantation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139874PMC
November 2018
3 Reads

A 15-Year Review of Corneal Transplant in Brazil.

Eye Contact Lens 2018 Nov;44 Suppl 2:S376-S381

Department of Ophthalmology (H.G.A., N. Kara-José, R.Y.H., N. Kara-Junior), School of Medicine (Hospital das Clínicas of da Universidade de São Paulo- São Paulo- HC-USP), University of São Paulo, São Paulo, Brazil; and Department of Ophthalmology (R.Y.H.), Santa Casa de São Paulo, São Paulo, Brazil.

Purpose: To analyze 15-year of corneal transplant in Brazil.

Methods: Cross-sectional, retrospective, observational, and analytical study, between available data from the Brazilian Transplant Registry (January 2002-December 2016), collected by the Brazilian Association of Organ Transplantation was performed. The variables analyzed per year were number of corneal transplants, corneal transplants per million people (pmp), corneal transplant teams, and individuals on the waiting list for corneal transplants. Read More

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http://Insights.ovid.com/crossref?an=00140068-201811002-0006
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http://dx.doi.org/10.1097/ICL.0000000000000554DOI Listing
November 2018
5 Reads

Descemet Membrane Endothelial Keratoplasty for Failed Penetrating Keratoplasty: Visual Outcomes and Graft Survival.

Cornea 2019 Feb;38(2):151-156

Price Vision Group, Indianapolis, IN.

Purpose: To evaluate outcomes and graft survival of Descemet membrane endothelial keratoplasty (DMEK) for failed penetrating keratoplasty (PK).

Methods: Ninety-three DMEK procedures performed in 84 eyes of 77 patients with failed PK were retrospectively reviewed. The main outcomes were corrected distance visual acuity and graft survival assessed with Kaplan-Meier survival analysis and proportional hazards modeling taking follow-up into consideration. Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9674
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http://dx.doi.org/10.1097/ICO.0000000000001763DOI Listing
February 2019
1 Read

Does Same-Day Postoperative Increased Intraocular Pressure Affect Endothelial Cell Density After Descemet Membrane Endothelial Keratoplasty?

Cornea 2018 Dec;37(12):1484-1489

Ophthalmology Department, King's College Hospital, London, United Kingdom.

Purpose: High intraocular pressure (IOP) is common in association with intracameral air and gas tamponade after Descemet membrane endothelial keratoplasty (DMEK); yet its influence on endothelial cell survival is unknown. Our aim was to determine the effect of high IOP measured 2 hours after DMEK on 1-month endothelial cell density (ECD). The influence of other potentially relevant factors was also investigated. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001762DOI Listing
December 2018
2 Reads

Graft Survival after Penetrating Keratoplasty in Cases of Trabeculectomy versus Ahmed Valve Implant.

J Ophthalmol 2018 13;2018:9034964. Epub 2018 Aug 13.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Egypt.

Purpose: To compare the corneal graft survival rates after penetrating keratoplasty (PKP) in cases of post-PKP glaucoma managed by either trabeculectomy with mitomycin C or Ahmed glaucoma valve (AGV).

Methods: This study was a retrospective interventional comparative study that included 40 eyes of 40 patients. The included patients had undergone previous PKP for anterior segment reconstruction after microbial or fungal keratitis, chemical burns, trauma, or perforated corneal ulcer. Read More

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http://dx.doi.org/10.1155/2018/9034964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110003PMC
August 2018
3 Reads

Deep anterior lamellar keratoplasty versus penetrating keratoplasty in corneas showing a high or low graft rejection risk.

Eur J Ophthalmol 2018 Sep 3:1120672118797287. Epub 2018 Sep 3.

1 Complejo Hospitalario La Mancha Centro, Spain.

Purpose: To compare visual, topographic and topometric outcomes in patients subjected to deep anterior lamellar keratoplasty or penetrating keratoplasty showing a high or low risk of graft rejection.

Setting: Complejo Hospitalario La Mancha Centro, Ciudad Real, Spain.

Materials And Methods: Data were reviewed for consecutive patients with a corneal stroma disease undergoing deep anterior lamellar keratoplasty or penetrating keratoplasty over the period 2009-2015 at our centre by the same surgeon. Read More

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http://dx.doi.org/10.1177/1120672118797287DOI Listing
September 2018
18 Reads

Simultaneous penetrating keratoplasty and amniotic membrane transplantation in eyes with a history of limbal stem cell deficiency.

J Fr Ophtalmol 2018 Sep 27;41(7):583-591. Epub 2018 Aug 27.

CIC 1423, Pierre et Marie Curie University Paris 06, Centre Hospitalier National d'Ophtalmologie des XV-XX, Institut de la Vision, 28, rue de Charenton, 75571 Paris, France.

Purpose: To describe the outcomes of simultaneous penetrating keratoplasty (PK) and amniotic membrane transplantation (AMT) performed both as a ring-shaped graft and as a temporary patch in eyes with a history of limbal stem cell deficiency (LSCD).

Methods: Prospective observational case series including 48 simultaneous PK/AMT procedures (48 patients) in eyes with a history of partial or total LSCD. Patients with total LSCD were first treated with limbal stem cell transplantation. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.01.006DOI Listing
September 2018
2 Reads

Influence of Postoperative Intraocular Pressure on Graft Detachment After Descemet Membrane Endothelial Keratoplasty.

Cornea 2018 Nov;37(11):1347-1350

Eye Center, University Hospital Freiburg, Freiburg im Breisgau, Germany.

Purpose: Descemet membrane endothelial keratoplasty (DMEK) seems to be the most promising technique for treating endothelium-related disorders of the cornea. However, graft detachment is a frequent complication. It often can be treated by rebubbling procedures. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001677DOI Listing
November 2018
7 Reads

Mast cells contribute to the induction of ocular mucosal alloimmunity.

Am J Transplant 2018 Aug 21. Epub 2018 Aug 21.

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Beyond their historical role as the effector cells in allergic disorders, mast cells have been implicated in regulating both innate and adaptive immune responses. Possessing considerable functional plasticity, mast cells are abundant at mucosal surfaces, where the host and external environments interface. The purpose of this study was to evaluate the contribution of mast cells to allograft rejection at the ocular surface. Read More

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http://dx.doi.org/10.1111/ajt.15084DOI Listing
August 2018
13 Reads

Lamellar keratoplasty techniques.

Indian J Ophthalmol 2018 09;66(9):1239-1250

Division of Clinical Neuroscience, University of Nottingham, UK.

Lamellar keratoplasty (LK) has revolutionized corneal graft surgery in several ways. Deep anterior LK (DALK) has eliminated risk of failure due to endothelial rejection. Endothelial keratoplasty (EK) has almost eliminated induced astigmatism and the "weak" graft-host junction as seen with penetrating keratoplasty (PK) and also reduced the risk of endothelial rejection. Read More

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http://dx.doi.org/10.4103/ijo.IJO_95_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113816PMC
September 2018
3 Reads

Twenty years of limbal epithelial therapy: an update on managing limbal stem cell deficiency.

BMJ Open Ophthalmol 2018 10;3(1):e000164. Epub 2018 Aug 10.

Department of Cornea and External Diseases, Moorfields Eye Hospital-NHS Foundation Trust, London, UK.

Limbal stem cell damage after chemical injury, autoimmune disorders or iatrogenic trauma leads to corneal conjunctivalisation with new vessel formation, epithelium instability and visual loss. Limbal stem cell transplantation includes reconstructive surgical procedures to restore a corneal epithelium. The recognised options are: conjunctival limbal autograft, in which stem cells are taken from the patient's healthy eye; conjunctival limbal allograft, in which stem cells are taken from a living, related or dead donor and the keratolimbal allograft. Read More

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http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2018-000164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093197PMC
August 2018
13 Reads

Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival.

Am J Pathol 2018 Sep 7;188(9):2016-2024. Epub 2018 Aug 7.

Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address:

Corneal transplantation is the most prevalent form of tissue transplantation. The success of corneal transplantation mainly relies on the integrity of corneal endothelial cells (CEnCs), which maintain graft transparency. CEnC density decreases significantly after corneal transplantation even in the absence of graft rejection. Read More

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http://dx.doi.org/10.1016/j.ajpath.2018.05.010DOI Listing
September 2018
2 Reads

An integrated deep sequencing analysis of microRNAs in transplanted corneas.

Mol Immunol 2018 Sep 7;101:429-439. Epub 2018 Aug 7.

Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Illumina Hiseq 2500 deep sequencing was used to screen for differentially expressed genes (DEGs) in matched pairs of isograft corneas and normal corneas, allograft corneas and isograft corneas. Our results showed that 22 miRNAs were significantly upregulated and 4 were significantly downregulated in the isograft group when compared with the control group (P < 0.01), while 17 miRNAs were significantly upregulated and 3 were significantly downregulated in the allograft group when compared with the isograft group (P < 0. Read More

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http://dx.doi.org/10.1016/j.molimm.2018.06.014DOI Listing
September 2018
5 Reads
2.970 Impact Factor

Lamellar keratoplasty using femtosecond laser intrastromal lenticule for limbal dermoid: case report and literature review.

J Int Med Res 2018 Nov 8;46(11):4753-4759. Epub 2018 Aug 8.

1 Department of Ophthalmology, the First Hospital of Jilin University, Changchun, China.

Small incision refractive lenticule extraction (SMILE) is a femtosecond laser technique to correct myopia and myopic astigmatism. Herein, we report a technique where intrastromal lenticule obtained from the SMILE procedure served as a graft for lamellar keratoplasty in the management of a limbal dermoid. An 18-year-old woman presented to the clinic with a corneal-limbal mass in the right eye. Read More

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http://dx.doi.org/10.1177/0300060518790874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259413PMC
November 2018
18 Reads
1.095 Impact Factor