7,171 results match your criteria Corneal Abrasion


Clinical analysis and predictive factors associated with improved visual acuity of infectious endophthalmitis.

BMC Ophthalmol 2020 Jun 29;20(1):256. Epub 2020 Jun 29.

Department of Ophthalmfology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Tianjin, 300052, China.

Background: To describe the clinical characteristics and analyze the predictive factors associated with improved visual acuity of 359 patients with infectious endophthalmitis.

Methods: This study retrospectively analyzed 359 eyes of 359 patients with infectious endophthalmitis from January 2014 to December 2018. The findings summarized some epidemiological characteristics of these patients, including age, sex, occupation, patient visit time, etiology, causative organisms, therapy, and best-corrected visual acuity. Read More

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http://dx.doi.org/10.1186/s12886-020-01517-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325235PMC

Ocular Anterior Segment Pathology in the Emergency Department: A 5-Year Study.

Eye Contact Lens 2020 Jun 15. Epub 2020 Jun 15.

Department of Ophthalmology and Vision Science, UC Davis Eye Center, University of California, Davis, Sacramento, CA.

Introduction: Patients with ocular complaints frequently present to emergency departments (EDs) for care. Emergency department practitioners are often the first to evaluate these patients and determine the next steps in their care, which can be a challenging task. The purpose of this study is to determine the frequency of anterior segment pathology in the setting of the ED in hopes that this information will be useful in creating more effective management algorithms. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000720DOI Listing

A case of the blues: Inadvertent ocular injury from accidental instillation of blue ink.

Am J Ophthalmol Case Rep 2020 Sep 10;19:100773. Epub 2020 Jun 10.

Department of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, New York, NY, 10021, USA.

Purpose: Many consumer products and non-ophthalmic medications are packaged in plastic "eye dropper" bottles, posing a risk of accidental ocular chemical injury when these substances are mistaken for eye drops.

Observations: We present the case of an elderly glaucoma patient who mistook blue stamper ink for the glaucoma medication Combigan®, and suffered ocular injury as a result.

Conclusions And Importance: The packaging of non-ophthalmic products in plastic "eye dropper" bottles poses a significant risk of accidental ocular chemical injury. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296186PMC
September 2020

Review of proteomics approach to eye diseases affecting the anterior segment.

J Proteomics 2020 Jun 18:103881. Epub 2020 Jun 18.

Chemical Injuries Research Center, Systems biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

Visual impairment and blindness is a major health burden worldwide, and major ocular diseases causing visual impairment pertain to the anterior segment of the eye. Anterior segment ocular diseases are common, yet complex entities. Although many treatment options and surgical techniques are available for these ailments, the underlying cause and pathogenesis is still unclear. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103881DOI Listing

Corneal wound healing.

Authors:
Steven E Wilson

Exp Eye Res 2020 Jun 15;197:108089. Epub 2020 Jun 15.

Cole Eye Institute, I-32, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, United States. Electronic address:

The corneal wound healing response is typically initiated by injuries to the epithelium and/or endothelium that may also involve the stroma. However, it can also be triggered by immune or infectious processes that enter the stroma via the limbal blood vessels. For mild injuries or infections, such as epithelial abrasions or mild controlled microbial infections, limited keratocyte apoptosis occurs and the epithelium or endothelium regenerates, the epithelial basement membrane (EBM) and/or Descemet's basement membrane (DBM) is repaired, and keratocyte- or fibrocyte-derived myofibroblast precursors either undergo apoptosis or revert to the parent cell types. Read More

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http://dx.doi.org/10.1016/j.exer.2020.108089DOI Listing

Early treatment of bilateral fungal keratitis with corneal cross-linking as adjuvant therapy.

Oxf Med Case Reports 2020 Jun 13;2020(6):omaa032. Epub 2020 Jun 13.

Instituto de la Visión Cerro de las Rosas, Sanatorio Allende - Sede Cerro, Córdoba X5009CGE, Argentina.

Fungal keratitis is an ocular infection that has no standardized treatment. The etiological agents most frequently reported in the literature are spp., spp. Read More

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http://dx.doi.org/10.1093/omcr/omaa032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293138PMC

Corneal Thinning Induced by Self-administered Alum Substance: A Case Report and Analysis of the Active Components.

Middle East Afr J Ophthalmol 2020 Jan-Mar;27(1):59-61. Epub 2020 Apr 29.

Department of Emergency, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

We report a case of severe ocular injury and impaired vision after self-administration of alum. A 56-year-old female administered an alum substance in the left eye and experienced severe corneal thinning, a scar, and decreased vision. The active compounds in the alum substance were analyzed using scanning electron microscopy. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_215_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276163PMC

Corneal Endothelial Decompensation.

Klin Monbl Augenheilkd 2020 Jun 9;237(6):745-753. Epub 2020 Jun 9.

Stein Eye Institute, UCLA, Los Angeles, California, United States.

Endothelial decompensation can occur from a variety of insults to the endothelium that result in loss of stromal clarity. Direct insults to the endothelium commonly occur in inherited, inflammatory, traumatic, immunological, and infectious etiologies. These injuries may cause transient injury without decompensation, but repetitive injury or severe isolated injury can lead to permanent non-compensatory endothelial cell loss. Read More

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http://dx.doi.org/10.1055/a-1128-4445DOI Listing

Pediatric Ocular Trauma during Eid Festivities in Yemen.

Korean J Ophthalmol 2020 Jun;34(3):187-191

Pediatric Unit, Magrabi Eye Hospital, Sana'a, Yemen.

Purpose: We sought to elucidate causes of ocular trauma in children younger than 17 years of age during the Eid festivities in Sana'a, Yemen.

Methods: A prospective observational case series study was conducted in two tertiary emergency hospitals (Al-Thawra and Magrabi Hospital). The Eid Al-Fitr festive holidays in 2016 lasted 10 days from July 3 to 12. Read More

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http://dx.doi.org/10.3341/kjo.2019.0127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269732PMC

The Antiangiogenic Properties of Adipose-Derived Mesenchymal Stem/Stromal Cells in Corneal Neovascularization in a Rabbit Model.

Med Hypothesis Discov Innov Ophthalmol 2020 12;9(2):74-84. Epub 2020 Mar 12.

Faculty of Health Sciences, School of Medicine, Laboratory of Experimental Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

The purpose was to study the anti-angiogenic effect of adipose-derived mesenchymal stem/stromal cells (ADMSCs) on experimentally induced corneal injuries. Corneal neovascularization (NV) was induced by incising and subsequently suturing the corneal surface in 32 New Zealand rabbits. Following suturing, the rabbits were randomly allocated into 2 groups, and received either phosphate-buffered saline (PBS) (control) or ADMSCs, both administered via three different routes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134242PMC

Hyaluronic Acid-Pluronic®F127-Laden Soft Contact Lenses for Corneal Epithelial Healing: In Vitro and In Vivo Studies.

AAPS PharmSciTech 2020 Jun 2;21(5):162. Epub 2020 Jun 2.

Refractive Surgery Center, The Second People's Hospital of Jinan, No. 148, Jingyi Road, Huaiyin District, Jinan, 250022, Shandong Province, China.

Hyaluronic acid (HA) is widely used to treat various ocular diseases like dry eye syndrome, keratoconus, and other corneal epithelial injuries. The currently available eye drop solutions need frequent doses affecting the routine life style of patients. In this work, the silicone contact lens was designed to entrap HA and Pluronic®F127 to improve the wettability of the contact lens to treat various ocular diseases. Read More

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http://dx.doi.org/10.1208/s12249-020-01714-zDOI Listing

The proinflammatory cytokines IL-1β and TNF-α modulate corneal epithelial wound healing through p16 suppressing STAT3 activity.

J Cell Physiol 2020 May 31. Epub 2020 May 31.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Qingdao, China.

The proinflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are involved in the corneal inflammatory response and wound healing following corneal injuries. However, the mechanism by which proinflammatory cytokines modulate corneal epithelial wound healing remains unclear. In this study, we found that IL-1β or TNF-α was transiently elevated during corneal epithelial wound healing in mice. Read More

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http://dx.doi.org/10.1002/jcp.29823DOI Listing

Man With Right Eye Pain.

Ann Emerg Med 2020 06;75(6):e35-e36

Department of Emergency Medicine, Chi-Mei Medical Center, Tainan, Taiwan.

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http://dx.doi.org/10.1016/j.annemergmed.2020.01.005DOI Listing
June 2020
4.676 Impact Factor

A Systematic Review of Emerging Therapeutic Strategies in the Management of Chemical Injuries of the Ocular Surface.

Eye Contact Lens 2020 May 22. Epub 2020 May 22.

The Department of Ophthalmology (S.H.L.P., W.H.L.W., Y.B., A.C.Y.L., Y.K.C., K.C.S.), Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR; and Department of Ophthalmology (V.J.), University of Pittsburgh Medical Centre, Pittsburgh, PA.

Objectives: To evaluate recent in vivo studies on emerging therapies for managing corneal epithelial injuries.

Methods: The search was conducted on PubMed for articles published between January 2015 and September 2019 and in English language.

Results: Thirty studies were identified for evaluation, including those on mesenchymal stem cells, amniotic membrane-derived therapies, endogenous peptides and their inhibitors, as well as hydrogel therapies. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000715DOI Listing
May 2020
1.679 Impact Factor

[Clinical observation of ocular injury caused by chestnut burr].

Zhonghua Yan Ke Za Zhi 2020 May;56(5):370-375

Qingdao Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China.

To analyze the clinical characteristics and treatment of ocular injury caused by chestnut burr. Retrospective case series study. Data of 48 patients (48 eyes) with ocular injuries caused by chestnut burrs hospitalized in Qingdao Eye Hospital were collected from January 2013 to March 2019. Read More

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http://dx.doi.org/10.3760/cma.j.cn112142-20190604-00295DOI Listing

Spectrum of Ocular Injuries and Visual Outcome Following Firework Injury to the Eye.

J Emerg Trauma Shock 2020 Jan-Mar;13(1):39-44. Epub 2020 Mar 19.

Department of Ophthalmology, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Ocular injury due to fireworks requires urgent ophthalmic assessment and management to preserve vision.

Methods: Spectrum of injury, type of intervention, visual outcome, and reasons for visual loss were assessed in consecutive patients presenting over 2 years with firework-related eye injury. The final visual outcome was recorded as best-corrected visual acuity. Read More

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http://dx.doi.org/10.4103/JETS.JETS_62_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204946PMC

Arabinogalactan and hyaluronic acid in ophthalmic solution: Experimental effect on xanthine oxidoreductase complex as key player in ocular inflammation (in vitro study).

Exp Eye Res 2020 Jul 4;196:108058. Epub 2020 May 4.

Department of Research & Development, MD Italy, Via Cancelliera 12, 00041, Albano Laziale, Rome, Italy.

Dry eye syndrome is a common disease associated to eyes inflammation, irritation and tear film instability. The enzymatic complex of xanthine oxidoreductase (XOR) is involved in the generation of reactive oxygen species (ROS) and uric acid that, in the end, can cause reperfusion injuries, irritation and pathological conditions. Furthermore, in the eye, it has been proposed that oxygen free radicals might play a significant role in retinal ischemic damage. Read More

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http://dx.doi.org/10.1016/j.exer.2020.108058DOI Listing

The neuroregenerative effects of topical decorin on the injured mouse cornea.

J Neuroinflammation 2020 May 4;17(1):142. Epub 2020 May 4.

Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, 3053, Australia.

Background: The cornea is innervated with a rich supply of sensory nerves that play important roles in ocular surface health. Any injury or pathology of the corneal nerves increases the risk of dry eye disease and infection. This study aims to evaluate the therapeutic potential of topical decorin to improve corneal nerve regeneration in a mouse model of sterile epithelial abrasion injury. Read More

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http://dx.doi.org/10.1186/s12974-020-01812-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199348PMC
May 2020
5.408 Impact Factor

Stanniocalcin-1 (STC-1), a downstream effector molecule in latanoprost signaling, acts independent of the FP receptor for intraocular pressure reduction.

PLoS One 2020 4;15(5):e0232591. Epub 2020 May 4.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America.

Prostaglandin F2 alpha (PGF2α) analogues such as latanoprost are common first-line intraocular pressure (IOP) lowering medications. However, their clinical use is limited in some patient populations due to minimal or no IOP lowering response or side effects. In searching for a more targeted approach for IOP reduction, our lab recently identified Stanniocalcin-1 (STC-1) as a molecule that was required for latanoprost-mediated IOP reduction and also acted as a stand-alone IOP lowering agent. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232591PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197809PMC

Lenticular fungal infection caused by Aspergillus in a patient with traumatic corneal laceration: a case report.

BMC Ophthalmol 2020 May 1;20(1):173. Epub 2020 May 1.

Department of Cornea and Refractive Surgery, Kim's Eye Hospital, Myunggok Eye Research Institute, Konyang University College of Medicine, 136, Yeongshin-ro, Yeongdeungpo-gu, Seoul, South Korea.

Background: To report a case of lenticular infection caused by Aspergillus, which was diagnosed 13 weeks after traumatic corneal laceration.

Case Presentation: A 60-year-old woman presented with traumatic corneal laceration including anterior lens capsule rupture and traumatic cataract after being hit with a chestnut in the right eye. There were multiple injuries due to tiny thorns of the chestnut, including the conjunctiva, sclera, cornea, and anterior lens capsule. Read More

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http://dx.doi.org/10.1186/s12886-020-01441-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195745PMC

Retained eyelid bee stinger: A case of secondary corneal abrasion.

Am J Ophthalmol Case Rep 2020 Jun 20;18:100670. Epub 2020 Apr 20.

Davidorf Eye Group, 7320 Woodlake Avenue, Suite 190, West Hills, CA, 91307, USA.

Purpose: Bee sting injuries to the eye and surrounding tissue are an infrequent occurrence. Here we present an interesting Case of a 64 year old bee keeper who was stung in the left upper eyelid.

Observations: After the injury, she developed pain and inflammation of the eyelid though a few days after the injury noted increased eye pain. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183099PMC

Systemic treatment for severe concentrated sulfuric acid burns in an adult male at high altitude: A case report.

World J Clin Cases 2020 Apr;8(7):1337-1342

Department of Burns and plastic Surgery, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China.

Background: The aim of this study was to report a case of a patient who suffered from severe concentrated sulfuric acid burns while working at high altitude. This patient recovered after systemic treatment. We also provide a literature review for a better understanding of the disease. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i7.1337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176622PMC

NFE2L2 activator RS9 protects against corneal epithelial cell damage in dry eye models.

PLoS One 2020 22;15(4):e0229421. Epub 2020 Apr 22.

Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Japan.

Oxidative stress may cause ocular surface damage during the development of dry eye. Mammalian cells have defense systems against oxidative stress. A central regulator of the stress response is nuclear factor-erythroid 2-related factor 2 (NFE2L2). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229421PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176120PMC

Amblyopia therapy in children with penetrating corneal injuries.

Taiwan J Ophthalmol 2020 Jan-Mar;10(1):29-31. Epub 2020 Mar 4.

Department of Pediatric Ophthalmology and Strabismus, Shri Ganapati Netralaya, Jalna, Maharashtra, India.

Background: The role of part-time occlusion therapy in children with penetrating ocular injuries has not been studied. The aim of the study is to analyze the role of part-time occlusion therapy in children with penetrating ocular trauma following surgical intervention.

Materials And Methods: This is a retrospective case series with a median follow-up of 17 months (range: 3-105 months). Read More

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http://dx.doi.org/10.4103/tjo.tjo_13_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158934PMC

Conjunctival Implantation Cyst in the Orbicularis Oculi Muscle: Review of a Possible Origin From Displaced Stem Cells With a Differential Diagnosis.

Ophthalmic Plast Reconstr Surg 2020 Apr 16. Epub 2020 Apr 16.

Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear/Harvard Medical School, Boston, Massachusetts, U.S.A.

Purpose: To document a unique case of a corneal/conjunctival epithelial inclusion cyst located in the orbicularis oculi muscle with a comprehensive review of variant conjunctival cysts and simulating conditions.

Methods: Clinicopathologic case report with detailed histopathologic and immunohistochemical evaluation for cytokeratins combined with a tabulation of mimicking lesions and relevant literature citations.

Results: A 59-year-old man experienced severe blunt left periorbital trauma that resulted in a limbal partial-thickness corneal wound with an associated epithelial abrasion and a full-thickness eyelid laceration extending from the superior fornix to the margin. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001631DOI Listing

Antimicrobial Peptides Derived from the Immune Defense Protein CAP37 Inhibit TLR4 Activation by S100A9.

Invest Ophthalmol Vis Sci 2020 Apr;61(4):16

,.

Purpose: Corneal abrasion is a common eye injury, and its resolution can be seriously complicated by bacterial infection. We showed that topical application of the cationic antimicrobial protein of 37 kDa (CAP37) promotes corneal re-epithelialization in mice, and peptides derived from CAP37 can recapitulate the antibacterial and wound-healing effects of the full-length protein. The current study was designed to identify the molecular mechanisms mediating the wound-healing effect of CAP37 and derived bioactive peptides. Read More

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http://dx.doi.org/10.1167/iovs.61.4.16DOI Listing

Bicanalicular Intubation with the Kaneka Lacriflow for Proximal Lacrimal Drainage System Stenosis.

Clin Ophthalmol 2020 23;14:915-920. Epub 2020 Mar 23.

Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

Purpose: The Kaneka Lacriflow CL (Lacriflow) bicanalicular lacrimal intubation system was evaluated as a self-retaining alternative to traditional modalities for stenting and dilation of the lacrimal drainage system in proximal lacrimal drainage system stenosis.

Patients And Methods: A retrospective chart review was conducted to assess the use of the Lacriflow system for treatment of patients with punctal and canalicular stenosis. Anesthesia type, operative time, and complications were assessed. Read More

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http://dx.doi.org/10.2147/OPTH.S248423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125358PMC

[Post-traumaticaniridia long after cataract surgery].

Rev Med Liege 2020 Apr;75(4):210-212

Service d'Ophtalmologie, CHU Liège, Belgique.

Post-traumatic aniridia is an uncommon complication of blunt ocular trauma. When it is completed, it represents a 360-degree tear from the root of the iris to its insertion into the ciliary body. Since the introduction of the use of corneal micro-incisions in cataract surgery, some cases of complete tear of iris root have been observed in patients who suffered from violent trauma. Read More

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Dual drug-loaded coaxial nanofibers for the treatment of corneal abrasion.

Int J Pharm 2020 May 2;581:119296. Epub 2020 Apr 2.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

Corneal abrasion is a scratch wound on the surface of the anterior segment of the eye, which can predispose a patient to corneal infection and scarring, particularly if the cut penetrates to the deep corneal layers. Here we investigate a novel approach to co-administer an anti-scarring agent and an antibiotic, both being incorporated into one dosage form so as to accelerate wound closure and to treat any associated infection. More specifically, we have used electrospun fibers as a means of incorporating the two drugs into distinct compartments via coaxial electrospinning. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119296DOI Listing

Superior Optic Vein Thrombosis Related to Orbital Cellulitis Secondary to Aquatic Injury.

Cureus 2020 Feb 23;12(2):e7080. Epub 2020 Feb 23.

Neurology, Maltepe University, İstanbul, TUR.

A 52-year-old woman presented with orbital cellulitis and sixth cranial nerve palsy as a result of striking the tail of a stingray while swimming. Her ophthalmologic and neurologic examination showed injury of the conjunctiva, corneal abrasion without mention of foreign body, contusion of the eyelid, and isolated lateral gaze palsy and ptosis in the right eye. Orbital magnetic resonance (MR) imaging and MR venography showed orbital cellulitis, superior and lateral rectus edema, and thrombosis of the superior ophthalmic vein on the right eye. Read More

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http://dx.doi.org/10.7759/cureus.7080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093917PMC
February 2020

Clinical and Microbiological Features of Pediatric Endopthalmitis After Open Globe Injury in the North of VietNam.

Open Access Maced J Med Sci 2019 Dec 20;7(24):4306-4310. Epub 2019 Dec 20.

Vietnam Military Medical University (VMMU), Hanoi, Vietnam.

Background: Pediatric endophthalmitis after open-globe injury had its clinical features, microbiological profile different from those in aldults. In Viet Nam, there was no report on the clinical and microbiological characteristics of pediatric posttraumatic endophthalmitis. Therefore, we conduct this study. Read More

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http://dx.doi.org/10.3889/oamjms.2019.380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084016PMC
December 2019

Axonal debris accumulates in corneal epithelial cells after intraepithelial corneal nerves are damaged: A focused Ion Beam Scanning Electron Microscopy (FIB-SEM) study.

Exp Eye Res 2020 May 21;194:107998. Epub 2020 Mar 21.

Department of Anatomy and Cell Biology, The George Washington School of Medicine and Health Sciences, Washington DC, 20052, USA; Department of Ophthalmology, The George Washington School of Medicine and Health Sciences, Washington DC, 20052, USA. Electronic address:

The intraepithelial corneal nerves (ICNs) that innervate the corneal epithelium are maintained through interactions with corneal epithelial cells and the extracellular matrix they produce. One to several axons bundle together within the basal cell layer and extend parallel to the ocular surface or branch and extend apically. Here we use 3-dimentional (3D) ultrastructural reconstructions of control and trephine injured mouse corneal epithelium and stroma produced using Focused Ion Beam Scanning Electron Microscope (FIB-SEM) to determine whether corneal epithelial or immune cells resident in the epithelium remove axonal debris and degrade it in their lysosomes after trephine injury to the cornea. Read More

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http://dx.doi.org/10.1016/j.exer.2020.107998DOI Listing

A retrospective histologic study of 140 cases of clinically significant equine ocular disorders.

J Vet Diagn Invest 2020 May 24;32(3):382-388. Epub 2020 Mar 24.

Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA (Flores, Del Piero, Langohr).

Ocular diseases are an important category in equine medicine; however, most articles regarding histologic ocular lesions in horses are exclusive to a specific condition and do not provide a complete review of clinically significant ocular disease frequency in a diagnostic laboratory. We reviewed sections of equine eyes from 140 cases (98 enucleations [biopsies] and 42 autopsies) with clinically relevant ocular alterations at 2 diagnostic centers in the United States. The most common primary conditions were non-traumatic keratitis (36), equine recurrent uveitis (ERU; 31), traumatic injuries (22), ocular and periocular neoplasms (19), and uveitis and/or endophthalmitis resulting from sepsis (18). Read More

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http://dx.doi.org/10.1177/1040638720912698DOI Listing

Corneal epithelial basement membrane: Structure, function and regeneration.

Exp Eye Res 2020 May 13;194:108002. Epub 2020 Mar 13.

University of Sao Paulo, Sao Paulo, Brazil.

Basement membranes are highly specialized extracellular matrices. More than providing scaffolds, basement membranes are recognized as dynamic and versatile structures that modulate cellular responses to regulate tissue development, function, and repair. Increasing evidence suggests that, in addition to providing structural support to adjacent cells, basement membranes serve as reservoirs and modulators of growth factors that direct and fine-tune cellular functions. Read More

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http://dx.doi.org/10.1016/j.exer.2020.108002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217741PMC

Advanced Glycation End Products and Receptor (RAGE) Promote Wound Healing of Human Corneal Epithelial Cells.

Invest Ophthalmol Vis Sci 2020 03;61(3):14

,.

Purpose: We used a human corneal epithelial cell (HCE) line to determine the involvement of the advanced glycation end products (AGEs) / receptor for AGEs (RAGE) couple in corneal epithelium wound healing.

Methods: After wounding, HCE cells were exposed to two major RAGE ligands (HMGB1 and AGEs), and wound healing was evaluated using the in vitro scratch assay. Following wound healing, the HCE cells were used to study the influence of the RAGE ligands on HCE proliferation, invasion, and migration. Read More

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http://dx.doi.org/10.1167/iovs.61.3.14DOI Listing

A case of isolated bilateral cataract following high-voltage electrical injury.

Oman J Ophthalmol 2020 Jan-Apr;13(1):34-36. Epub 2020 Feb 17.

Department of Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India.

High voltage electric burns can cause various ocular injuries and may manifest in the form of conjunctival hyperemia, corneal opacities, uveitis, miosis, spasm of accommodation, cataract, retinal edema, papilledema, choroidal rupture, chorio-retinal necrosis/atrophy, retinal detachment and optic atrophy. The involvement of crystalline lens exclusively with sparing of other ocular structures is rare. We report a case of 16 year old male with bilateral total cataract after electrical injury by over-head high tension electric transmission cable accidentally falling on patient's head 6 months back. Read More

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http://dx.doi.org/10.4103/ojo.OJO_129_2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050452PMC
February 2020

Traumatic laser in situ keratomileusis flap dislocation with epithelial ingrowth, Propionibacterium acnes infection, and diffuse lamellar keratitis: A case report.

Medicine (Baltimore) 2020 Mar;99(10):e19257

Department of Ophthalmology, Buddhist Tzu Chi General Hospital.

Rationale: Traumatic flap dislocation might occur anytime after laser in situ keratomileusis (LASIK), but it is rarely concomitantly complicated with epithelial ingrowth, infectious keratitis, and diffuse lamellar keratitis altogether. Here we report a case of traumatic LASIK flap inversion with epithelial ingrowth, Propionibacterium acnes infection, and diffuse lamellar keratitis.

Patient Concerns: A 42-year-old man receiving bilateral LASIK surgery 10 years ago complained of right eye pain for 6 days after twig injury. Read More

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http://dx.doi.org/10.1097/MD.0000000000019257DOI Listing

Development and Characterization of a Benchtop Corneal Puncture Injury Model.

Sci Rep 2020 Mar 6;10(1):4218. Epub 2020 Mar 6.

Sensory Trauma Research Department, United States Army Institute of Surgical Research, Fort Sam Houston, TX, 78234, USA.

During recent military operations, eye-related injuries have risen in frequency due to increased use of explosive weaponry which often result in corneal puncture injuries. These have one of the poorest visual outcomes for wounded soldiers, often resulting in blindness due to the large variations in injury shape, size, and severity. As a result, improved therapeutics are needed which can stabilize the injury site and promote wound healing. Read More

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http://dx.doi.org/10.1038/s41598-020-61079-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060308PMC

Deployed ophthalmic workload in support of US and NATO operations in Afghanistan.

BMJ Mil Health 2020 Mar 5. Epub 2020 Mar 5.

Warfighter Eye Center, Malcolm Grow Medical Clinics and Surgery Center, Joint Base Andrews, Maryland, USA.

Purpose: The extent and types of ophthalmic disease and non-battle injury (DNBI) seen by expeditionary ophthalmologists at deployed military medical treatment facilities have not previously been reported. We aim to characterise the extent and type of ophthalmic pathology including DNBI at a US military medical treatment facility in Afghanistan.

Methods: We conducted a retrospective non-interventional cohort study of all patients seen by ophthalmologists at Craig Joint Theater Hospital at Bagram Airfield (BAF), Afghanistan, between 1 October 2018 and 31 August 2019. Read More

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http://dx.doi.org/10.1136/bmjmilitary-2019-001379DOI Listing

The effect of Tegaderm™ versus EyeGard® on eyelid erythema during general anesthesia: a randomized-controlled trial.

Can J Anaesth 2020 May 13;67(5):560-567. Epub 2020 Feb 13.

Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, 800 Washington Street, Box 298, Boston, MA, USA.

Purpose: Application of adhesive tape to the eyelids during general anesthesia decreases the risk of corneal abrasion but may increase the risk of eyelid injury. The aim of this study was to determine if there is a difference in eyelid erythema when covering the eyelid with either Tegaderm™ or an EyeGard®.

Methods: We conducted a prospective, randomized, double-blind, split-face study of patients undergoing general anesthesia at an urban tertiary care academic medical centre. Read More

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http://dx.doi.org/10.1007/s12630-020-01588-6DOI Listing

Fibrocytes, Wound Healing, and Corneal Fibrosis.

Invest Ophthalmol Vis Sci 2020 02;61(2):28

,.

Purpose: This review highlights the roles of fibrocytes-their origin, markers, regulation and functions-including contributions to corneal wound healing and fibrosis.

Methods: Literature review.

Results: Peripheral blood fibroblast-like cells, called fibrocytes, are primarily generated as mature collagen-producing cells in the bone marrow. Read More

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http://dx.doi.org/10.1167/iovs.61.2.28DOI Listing
February 2020

LASIK flap stability after severe ocular injury.

Am J Ophthalmol Case Rep 2020 Jun 30;18:100608. Epub 2020 Jan 30.

Naval Medical Center San Diego, San Diego, CA, USA.

Purpose: To report two cases of LASIK flap stability after severe ocular trauma.Observations: Two patients suffered open globe injuries several years after undergoing uneventful LASIK with femtosecond laser corneal flap. Both underwent primary ruptured globe repair, during which no LASIK flap dislocation was identified. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016373PMC

Histological study of the effect of granulocyte colony-stimulating factor on experimentally induced corneal burn in adult male albino rats.

Ultrastruct Pathol 2020 Jan 21;44(1):116-129. Epub 2020 Feb 21.

Histology and Cell Biology Department, Tanta University, Tanta, Egypt.

Chemical injuries to the eye represent one of the true ophthalmic emergencies that require immediate and intensive intervention to minimize severe complications and visual loss. Granulocyte colony-stimulating factor (G-CSF) is a potent hematopoietic cytokine that influences the proliferation, survival, maturation, and the functional activation of granulocytes. The present work was performed to evaluate the histological effect of G-CSF in treating rat corneal alkali burn model. Read More

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http://dx.doi.org/10.1080/01913123.2020.1713949DOI Listing
January 2020

[New progress in the reuse of human corneal stromal lenticules from SMILE].

Authors:
Y F Shang F J Zhang

Zhonghua Yan Ke Za Zhi 2020 Feb;56(2):144-148

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China.

With the extensive development of small incision lenticule extraction (SMILE), a large number of human corneal stromal lenticules were extracted integrally during the operation, which led some experts to study the reuse of the lenticules. In experimental research, the lenticules were used to culture fibroblasts, construct corneal scaffolds and describe the biomechanical behaviors of cornea by cytobiology, immunology and biomechanics. In clinical study, the lenticules had been successfully reimplanted into autologous or allogenic cornea of human subjects for correcting hyperopia and presbyopic, patching corneal perforation and treating defective keratopathy and so on. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2020.02.013DOI Listing
February 2020

Corneal Endothelial Cell Toxicity Determines Long-Term Outcome After Ocular Exposure to Sulfur Mustard Vapor.

Cornea 2020 May;39(5):640-648

Departments of Neuroscience and Toxicology, US Army Medical Research Institute of Chemical Defense, Gunpowder, MD.

Purpose: Ocular exposure to sulfur mustard (SM) vapor causes acute loss of corneal endothelial cells (CECs). Persistent corneal endothelial pathologies are observed in eyes that do not recover from SM exposure, suggesting that endothelial toxicity contributes to mustard gas keratopathy (MGK). Here, we evaluated the contributions of endothelial loss to acute and chronic corneal injuries in SM-exposed eyes. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002278DOI Listing
May 2020
2.360 Impact Factor

Epidemiology of Eye Injuries Resulting in Hospitalization, a Referral Hospital-Based Study.

Clin Ophthalmol 2020 6;14:1-6. Epub 2020 Jan 6.

Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Purpose: To determine the characteristics of hospitalized eye injuries in Northern Thailand, a tertiary referral center.

Methods: The medical records of patients who sustained an eye injury and were admitted to the Department of Ophthalmology, Chiang Mai University, Thailand, from February 2015 to February 2016 were retrospectively reviewed. Demographics and characteristics of each injury were collected. Read More

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http://dx.doi.org/10.2147/OPTH.S234035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954083PMC
January 2020

Case Report: Evaluating Intraocular Foreign Bodies After Corneal Perforation Using Swept Source Anterior Segment Optical Coherence Tomography.

Optom Vis Sci 2020 02;97(2):101-103

Department of Ophthalmology, Hospital Universitari i Politecnic La Fe, Valencia, Spain.

Significance: Use of anterior segment optical coherence tomography (OCT) is reported, exploring its advantages over other examination techniques.

Purpose: The purpose of this study was to report a case in which anterior segment OCT was used to evaluate the presence of intraocular bodies after corneal perforation.

Case Report: A 33-year-old man was referred to our ophthalmology department after traumatic ocular injury. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001475DOI Listing
February 2020

Topical Pergolide Enhance Corneal Nerve Regrowth Following Induced Corneal Abrasion.

Invest Ophthalmol Vis Sci 2020 01;61(1)

,.

Purpose: Neurotrophic keratopathy is a degenerative disease that may be improved by nerve growth factor (NGF). Our aim was to investigate the use of pergolide, a dopamine (D1 and D2) receptor agonist known to increase the synthesis and release of NGF for regeneration of damaged corneal nerve fibers.

Methods: Pergolide function was evaluated by measuring axon length and NGF levels by enzyme-linked immunosorbent assay in cultured chicken dorsal root ganglion (DRG) cells with serial doses of pergolide (10, 25, 50, 150, and 300 µg/ml) and with different concentrations of a D1 antagonist. Read More

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http://dx.doi.org/10.1167/iovs.61.1.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205105PMC
January 2020