109,394 results match your criteria Corneal Abrasion


Hypohidrotic Ectodermal Dysplasia: A Rare Disorder with Bilateral Infantile Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma and anterior segment, Dr. Shroff's charity eye hospital, Delhi.

Ectodermal dysplasia is a disorder that occurs due to abnormalities of ectodermal structures such as skin, teeth, hair, nails, and eccrine glands. Approximately 200 different conditions have been identified as ectodermal dysplasia, the most common being hypohidrotic ectodermal dysplasia (HED). It is characterized by hypotrichosis (sparse scalp or body hair), hypodontia (absent or malformed teeth) and hypohidrosis (reduced ability to sweat). Read More

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December 2018
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Long-term Evaluation of Corneal Biomechanical Properties After Corneal Cross-linking for Keratoconus: A 4-Year Longitudinal Study.

J Refract Surg 2018 Dec;34(12):849-856

Purpose: To compare the long-term changes in corneal biomechanics, topography, and tomography before and 4 years after corneal cross-linking (CXL) with the Dresden protocol and correlate these changes with visual acuity.

Methods: In this longitudinal study, 18 eyes of 18 patients with progressive keratoconus who were treated with CXL were included. All patients received a standard ophthalmological examination and were examined by Placido disc-based topography, Scheimpflug tomography, and biomechanical assessments with the Corvis ST (OCULUS Optikgeräte GmbH, Wetzlar, Germany) and Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments, Buffalo, NY) before and 4 years after CXL. Read More

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December 2018

Tomographic and Biomechanical Scheimpflug Imaging for Keratoconus Characterization: A Validation of Current Indices.

J Refract Surg 2018 Dec;34(12):840-847

Purpose: To analyze the potential benefit of the newly developed Tomography and Biomechanical Index (TBI) for early keratoconus screening.

Methods: In this retrospective study, the discriminatory power of the corneal tomography Belin/Ambrósio Enhanced Ectasia Display (BAD-D) index and the newly developed Corvis Biomechanical Index (CBI) and TBI to differentiate between normal eyes, manifest keratoconus eyes (KCE), very asymmetric keratoconus eyes with ectasia (VAE-E), and their fellow eyes with either regular topography (VAE-NT) or regular topography and tomography (VAE-NTT) were analyzed by applying the t test (for normal distribution), Wilcoxon matched-pairs test (if not normally distributed), and receiver operating characteristic curve (ROC). The DeLong test was used to compare the area under the ROC (AUROC). Read More

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December 2018

Clinical Outcomes Using a Novel Image-Guided Planning System in Patients With Cataract and IOL Implantation.

J Refract Surg 2018 Dec;34(12):824-831

Purpose: To determine the proportion of eyes with preexisting astigmatism achieving 0.50 diopters (D) or less of residual refractive cylinder 3 months after either implantation of toric intraocular lenses (IOLs) or corneal incisions using the VERION system (Alcon Laboratories, Inc., Fort Worth, TX) measurement module and digital markers for microscope (M) and laser (L). Read More

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December 2018

Suction Stability Management in SMILE: Development of a Decision Tree for Managing Eye Movements and Suction Loss.

J Refract Surg 2018 Dec;34(12):809-816

Purpose: To develop a comprehensive protocol for suction stability management during small incision lenticule extraction (SMILE).

Methods: This was a retrospective video review of all SMILE cases where suction loss occurred or eye movement was noted in the medical record. The different types of eye movement were collated. Read More

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December 2018

The Impact of Photorefractive Keratectomy and Mitomycin C on Corneal Nerves and Their Regeneration.

J Refract Surg 2018 Dec;34(12):790-798

Purpose: To determine how photorefractive keratectomy (PRK) and mitomycin C (MMC) affect corneal nerves and their regeneration over time after surgery.

Methods: Twenty-eight New Zealand rabbits had corneal epithelial scraping with (n = 3) and without (n = 3) MMC 0.02% or -9. Read More

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December 2018

Neobenedenia melleni (Monogenea: Capsalidae) in ornamental reef fish imported to Brazil.

Rev Bras Parasitol Vet 2018 Dec 10. Epub 2018 Dec 10.

Laboratório AQUOS - Sanidade de Organismos Aquáticos, Departamento de Aquicultura, Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brasil.

The capsalid monogenean Neobenedenia melleni is known as a lethal pathogen for captured marine teleost ornamental fish, if left untreated. This study reports the occurrence of N. melleni parasitizing four species of ornamental reef fish imported into Brazil and maintained in quarantine: Arabian angelfish (Pomacanthus asfur ), yellowbar angelfish (Pomacanthus maculosus), regal angelfish (Pygoplites diacanthus), and bluecheek butterflyfish (Chaetodon semilarvatus). Read More

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December 2018

Using intracameral vital dye as a guide for venting incision in acute corneal hydrops.

Eur J Ophthalmol 2018 Dec 12:1120672118818012. Epub 2018 Dec 12.

Ocular Trauma and Emergency Department and Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose:: To introduce a new surgical technique for the localization of corneal bulla to drain a massive corneal hydrops.

Methods:: Four consecutive cases with acute large protruded hydrops were selected. A limbal paracentesis was made via 15° blade. Read More

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December 2018

[Corneal dystrophies in optical coherence tomography].

Ophthalmologe 2018 Dec 11. Epub 2018 Dec 11.

Augenklinik, Ludwig-Maximilians-Universität, Mathildenstr. 8, 80336, München, Deutschland.

Background: Corneal optical coherence tomography (anterior segment OCT, AS-OCT) is described in the current IC3D classification of corneal dystrophies to be a method for improvement of clinical diagnostics and treatment.

Objective: In this case series AS-OCT images of corneal dystrophies were analyzed with respect to morphological changes.

Material And Methods: This was a retrospective imaging and morphological case series with 38 eyes. Read More

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December 2018

Blindness and eye disease in a Tibetan region of China: findings from a Rapid Assessment of Avoidable Blindness survey.

BMJ Open Ophthalmol 2018 17;3(1):e000209. Epub 2018 Nov 17.

British Columbia Center for Epidemiology & International Ophthalmology and Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada.

Introduction: The only population-based survey of blindness and visual impairment of a Tibetan population was conducted in the Tibet Autonomous Region in 1999.

Methods And Analysis: The Rapid Assessment of Avoidable Blindness methodology was used to conduct a survey of Kandze Tibetan Autonomous Prefecture, Sichuan Province of China in the Fall 2017. Using the 2010 census, 100 clusters of 50 participants aged 50 years or older were randomly sampled using probability proportionate to size. Read More

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November 2018

Intraocular lens dislocation: a novel in-situ scleral refixation technique using a 25 Gauge trocar in the anterior chamber.

BMJ Open Ophthalmol 2018 23;3(1):e000174. Epub 2018 Nov 23.

Dipartimento Neuromuscoloscheletrico e Organi di Sensi, Università degli Study di Firenze, Florence, Italy.

Objective: Intraocular lens (IOL) repositioning using a closed-eye approach could be carried out in some selected cases. Our study focuses on the efficacy and safety of a IOL closed-eye repositioning technique using scleral suture, which is performed using a trocar as an intrastromal limbal guide.

Methods And Analysis: Thirty-one eyes of 31 patients with late IOL dislocation operated on between January 2015 and May 2017 were included in this retrospective non-comparative consecutive case series study. Read More

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November 2018

Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation.

J Ophthalmol 2018 12;2018:6537413. Epub 2018 Nov 12.

Associate Professor, Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Purpose: To study the effect of D-panthenol (provitamin B5) on corneal epithelial healing, in cases of surface laser ablation. : 45 eyes, of 45 patients undergoing laser surface ablation, received D-panthenol 2% in one eye and artificial tear drops of similar composition not containing D-panthenol in the other eye, postoperatively, for 2 months. Patients were examined daily for 3 days after the procedure. Read More

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November 2018

Comparison between Transepithelial Photorefractive Keratectomy versus Alcohol-Assisted Photorefractive Keratectomy in Correction of Myopia and Myopic Astigmatism.

J Ophthalmol 2018 12;2018:5376235. Epub 2018 Nov 12.

Ophthalmology Department, Security Forces Hospital, Riyadh, Saudi Arabia.

Purpose: The aim of the study was to compare visual acuity, refractive results, safety, and efficacy of TPRK with AAPRK as primary outcomes and surgical time, pain scores, haze levels, and healing time as secondary outcomes in TPRK and AAPRK groups.

Setting: Security Forces Hospital, Ophthalmology Department, Riyadh, Kingdom of Saudi Arabia.

Design: Prospective, nonrandomized case-control comparative study. Read More

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November 2018

Predictive Factors for Successful Type 1 Big Bubble during Deep Anterior Lamellar Keratoplasty.

J Ophthalmol 2018 13;2018:4685406. Epub 2018 Nov 13.

Centre Hospitalier National d'Ophtalmologie des 15-20, Sorbonne Université, Paris, France.

Objective: Big bubble (BB)-deep anterior lamellar keratoplasty (DALK) has become the reference transplantation technique for corneal stromal disorders. Type 1 BB is the desired aspect but it is not constant. We aimed to determine the predictive factors of type 1 BB success. Read More

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November 2018

The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.

Interdiscip Perspect Infect Dis 2018 13;2018:2525173. Epub 2018 Nov 13.

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. Read More

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November 2018

The effect of cold tetracaine on the severity of burning sensation upon instillation.

Clin Ophthalmol 2018 20;12:2377-2382. Epub 2018 Nov 20.

Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, Thailand,

Purpose: Tetracaine is one of the most common eye drops that are used for analgesia in clinical practice. However, it causes ocular burning sensation when instilled. This study aimed to compare the effects of the cold and room temperature tetracaine on burning sensation. Read More

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November 2018

A novel scale for describing corneal staining.

Clin Ophthalmol 2018 19;12:2369-2375. Epub 2018 Nov 19.

Centre for Ocular Research & Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada,

The assessment of corneal staining is a commonly conducted procedure in both clinical practice and as part of various research studies. Different grading scales are employed by many clinicians and researchers to undertake this procedure for corneal staining comparisons between eyes, products and over time. This paper describes the development and use of a grading scale for corneal staining undertaken at an academic research site. Read More

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November 2018

Evaluation estrogen, progesteron and androgen receptor expressions in corneal epithelium in keratoconus.

Cont Lens Anterior Eye 2018 Dec 8. Epub 2018 Dec 8.

Hacettepe University, Bioengineering, Ankara, Turkey.

Purpose: To evaluate the role of sex steroid hormone receptors in corneal epithelium in etiopathogenesis of keratoconus (KC).

Methods: Thirty patients with KC who were planned for corneal collagen-crosslinking and 20 patients who were planned for excimer laser for refractive errors included in this study. Corneal epitheliums were curated mechanically during surgeries. Read More

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December 2018

Effects of ranibizumab (Lucentis®) and bevacizumab (Avastin®) on human corneal endothelial cells.

BMC Ophthalmol 2018 Dec 11;18(1):316. Epub 2018 Dec 11.

Department of Ophthalmology, University of Heidelberg, Lions Eye Bank, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Ingrowth of newly formed blood and lymph vessels (angiogenesis) from the limbus region into the cornea can be treated successfully by subconjunctival application of antiangiogenic agents. Currently, there are several angiogenesis inhibitors from various manufacturers available, such as vascular endothelial growth factor (VEGF) antibodies. The aim of the study was to investigate potential cytotoxic effects of two anti-VEGF agents, ranibizumab (Lucentis®) and bevacizumab (Avastin®) on the human corneal endothelium. Read More

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December 2018

The impact of a hyaluronic acid-grafted layer on the surface properties of model silicone hydrogel contact lenses.

Langmuir 2018 Dec 12. Epub 2018 Dec 12.

The introduction of high oxygen transmissibility silicone hydrogel lenses ameliorated hypoxia-related complications, making them the most prescribed type of contact lens. Despite the progress made over the last two decades to improve their clinical performance, symptoms of ocular dryness and discomfort and a variety of adverse clinical events are still reported. Consequently, the rate of contact lens wear discontinuation has not been appreciably diminished by their introduction. Read More

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December 2018

Future clinical applicability of optical coherence tomography angiography.

Clin Exp Optom 2018 Dec 11. Epub 2018 Dec 11.

Ocular Imaging Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Optical coherence tomography angiography (OCT-A) is an emerging technology that allows for the non-invasive imaging of the ocular microvasculature. Despite the wealth of observations and numerous research studies illustrating the potential clinical uses of OCT-A, this technique is currently rarely used in routine clinical settings. In this review, technical and clinical aspects of OCT-A imaging are discussed, and the future clinical potential of OCT-A is considered. Read More

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December 2018

Pre-operative factors influencing post-operative outcomes from MyoRing implantation in keratoconus.

Clin Exp Optom 2018 Dec 7. Epub 2018 Dec 7.

Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Background: To identify pre-operative factors that influence post-operative performance of a full-ring intra-corneal implant (MyoRing) for the management of keratoconus.

Method: In a retrospective study, medical records of 70 keratoconus eyes of 70 consecutive surgical patients with a mean age of 28.54 ± 6. Read More

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December 2018

Use of commercially available sodium hyaluronate 0.18% eye drops for corneal epithelial healing in diabetic patients.

Int Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Purpose: To evaluate the effect of topical sodium hyaluronate (SH) 0.18% treatment on corneal epithelial healing after epithelial debridement in pars plana vitrectomy in diabetic patients.

Method: This is prospective and randomized clinical trial. Read More

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December 2018

Visual acuity in patients with keratoconus: a comparison with matched regular myopic astigmatism.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Barzilai Medical Center, Ashkelon and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel.

Purpose: To compare uncorrected distance visual acuity (UDVA) and best-corrected distance visual acuity (CDVA) between patients with keratoconus (KC) and matched patients with regular myopic astigmatism.

Methods: This retrospective study included consecutive patients diagnosed with KC between 2008 and 2013 at Care-Vision Laser Centers, Tel-Aviv, Israel, and matched patients with regular myopic astigmatism. Data included were central corneal thickness (CCT), spherical equivalent (SE), cylinder (CYL), mean keratometric power, maximum keratometric power (K), UDVA, CDVA, and defocus equivalent (DEQ). Read More

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December 2018

Correlation between age and corneal edema in pediatric patients with Peters anomaly.

Int Ophthalmol 2018 Dec 8. Epub 2018 Dec 8.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL, 33136, USA.

Purpose: To evaluate corneal edema in different-aged pediatric patients with Peters anomaly and to correlate in vivo with ex vivo histopathologic findings.

Methods: A retrospective cross-sectional study was performed. The medical records of patients diagnosed with Peters anomaly who underwent examination under anesthesia (EUA) between 2011 and 2015 were reviewed. Read More

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December 2018

[Clinical picture and diagnosis of neurotrophic keratopathy].

Authors:
E M Messmer

Ophthalmologe 2018 Dec 7. Epub 2018 Dec 7.

Augenklinik, Ludwig-Maximilians-Universität München, Mathildenstr. 8, 80336, München, Deutschland.

Background: Neurotrophic keratopathy is characterized by corneal surface alterations, persistent corneal epithelial defects and/or corneal ulcerations associated with corneal sensory abnormalities. Due to the variable clinical picture neurotrophic keratopathy is often overlooked or diagnosed too late in the course of the disease.

Objective: Discussion of the clinical picture of neurotrophic keratopathy and recommendations for correct diagnosis. Read More

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December 2018

In vivo histology and p.L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy.

Jpn J Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Purpose: To report genetic mutational analysis and in vivo histology of Meesmann corneal dystrophy.

Study Design: Prospective, case control study.

Methods: Six patients from three independent families with clinically diagnosed Meesmann corneal dystrophy were enrolled in this study. Read More

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December 2018

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5836-5846

Allergan plc, Irvine, California, United States.

Purpose: DARPin molecules are a novel class of small proteins that contain engineered ankyrin repeat domain(s) and bind to target proteins with high specificity and affinity. Abicipar-pegol (abicipar), a DARPin molecule targeting vascular endothelial growth factor-A (VEGF-A), is currently under evaluation in patients with age-related macular degeneration. The pharmacodynamic properties of abicipar were characterized using in vivo and in vitro assays. Read More

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December 2018

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5824-5835

Department of Biology, University of Victoria, Victoria, British Columbia, Canada.

Purpose: Despite numerous studies associating Visual System Homeobox 1 (VSX1), with posterior polymorphous corneal dystrophy and keratoconus, its role in these diseases is unclear. Here we examine the pathogenicity of VSX1 missense mutations in vitro and in a mouse genetic model.

Methods: Vsx1 transcriptional repressor activity, protein stability, and subcellular localization activity, was examined using luciferase reporter-based assays, western blotting and immunolabeling, respectively, in transfected human embryonic kidney 293T cells. Read More

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December 2018

A New Method to Analyze the Relative Corneal Refractive Power and Its Association to Myopic Progression Control With Orthokeratology.

Transl Vis Sci Technol 2018 Nov 30;7(6):17. Epub 2018 Nov 30.

School of Optometry and Ophthalmology, Tianjin Medical University Eye Hospital, Tianjin, China.

Purpose: We present a new method for analyzing relative corneal refractive power (RCRP) in children undergoing orthokeratology and explore its potential association to effective myopic control.

Methods: A total of 55 children aged 8 to 12 years participated in the study. Axial growth was calculated as the difference in axial length before and 1 year after orthokeratology. Read More

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November 2018

Pentacam HR Indices Variation in Normal Corneas with Different Corneal Thickness.

J Ophthalmol 2018 8;2018:9328120. Epub 2018 Nov 8.

Ophthalmology Department, Cairo University, Al Watany Eye Hospital and Watany Research and Development Center (WRDC), Cairo, Egypt.

Purpose: To evaluate the effect of variable corneal thickness on Pentacam HR diagnostic indices in normal corneas.

Methods: Retrospective study was conducted at Al Watany Eye Hospital, Cairo, Egypt. Consecutive 160 eyes of young myopic subjects without KC were evaluated using Pentacam HR (WaveLight Allegro Oculyzer II, Erlangen, Germany). Read More

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November 2018

Graft rejection-like reactions in the early postoperative period after deep anterior lamellar keratoplasty for keratoconus: a retrospective study.

Clin Ophthalmol 2018 14;12:2315-2322. Epub 2018 Nov 14.

Department of Ophthalmology, Japan Community Health Care Organization Hoshigaoka Medical Center, Hirakata, Osaka 573-8511, Japan.

Background: Deep anterior lamellar keratoplasty (DALK) is indicated to correct high astigmatism in patients with keratoconus (KC) and no evidence of Descemet's membrane rupture. However, some patients with KC experience graft rejection-like inflammatory reactions within 2 months (usually in the first week) after DALK. The aim of this study was to identify the characteristics and influencing factors of these reactions by reviewing the records of patients who underwent DALK or penetrating keratoplasty (PKP) for KC or other corneal problems. Read More

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November 2018

Masking of Papilledema by Glaucoma.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):330-331

Department of Cornea and IOL, AG Eye Hospital, Trichy, Tamil Nadu, India.

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December 2018

Femtosecond Laser-Assisted Deep Lamellar Descemet Membrane Endothelial Keratoplasty for the Treatment of Endothelial Dysfunction Associated With Posterior Stromal Scarring.

Cornea 2018 Dec 7. Epub 2018 Dec 7.

Cornea, Cataract and Refractive Surgery Unit, Vissum Corporación, Alicante, Spain.

Purpose: To describe an alternative surgical approach, femtosecond laser-assisted deep lamellar Descemet membrane endothelial keratoplasty (Femto-DL-DMEK), for the treatment of corneal endothelial diseases associated with posterior stromal scarring.

Methods: Case report of a 52-year-old man with pseudophakic bullous keratopathy and posterior corneal scarring secondary to viral endotheliitis who underwent Femto-DL-DMEK. The surgical technique was as follows: First, a manual lamellar dissection plane was created at approximately 75% to 85% depth through a 5. Read More

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December 2018

Vitamin D Enhances the Efficacy of Topical Artificial Tears in Patients With Dry Eye Disease.

Cornea 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Hallym University College of Medicine, Seoul, Korea.

Purpose: To investigate the efficacy of topical carbomer-based lipid-containing artificial tears (CLAT) and hyaluronate (HU) in patients with dry eye disease (DED) based on serum 25-hydroxyvitamin D (25HD) levels and cholecalciferol (vitamin D) supplementation.

Methods: A total of 116 patients with DED from June 2015 to June 2016 were included. The participants were divided into the vitamin D deficiency (VDD) group and the non-VDD group according to their serum 25HD levels. Read More

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December 2018

Retroposition of the Globe After Le Fort III Midfacial Distraction.

J Craniofac Surg 2018 Dec 10. Epub 2018 Dec 10.

Harvard Medical School.

Background: Patients with syndromic craniosynostosis exhibit exorbitism due to supraorbital and midfacial retrusion. This study documented the change in sagittal orbital-globe relationship following Le Fort III midfacial advancement.

Methods: This retrospective case series comprised patients with syndromic craniosynostosis who underwent midfacial distraction from 1997 to 2016. Read More

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December 2018

Periocular Manifestations of Afatinib Therapy.

Ophthalmic Plast Reconstr Surg 2018 Dec 4. Epub 2018 Dec 4.

Oxford University Hospital, Headley Way, Headington, Oxford, United Kingdom.

Epidermal growth factor receptor tyrosine kinase inhibitor therapy has been increasingly employed in the treatment of a variety of tumors. The authors report the rarely documented side effect of trichiasis with the use of Afatinib in a patient with spinal chordoma and review-related literature. A 67-year-old lady was referred to the oculoplastic service with a 3-month history of ocular irritation and pain associated with blurred vision. Read More

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December 2018

Glaucoma Work-up in Congenital Zika Syndrome.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology and Visual Sciences, Federal University of Sa[Combining Tilde]o Paulo, Sa[Combining Tilde]o Paulo, Brazil.

Purpose: To perform a glaucoma work-up in infants with congenital Zika syndrome (CZS).

Patient And Methods: This cross-sectional study included 188 eyes of 107 children (1.1 ± 0. Read More

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December 2018

Development of Inflammatory Hypoxia and Prevalence of Glycolytic Metabolism in Progressing Herpes Stromal Keratitis Lesions.

J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201; and

Chronic inflammation in tissues often causes the development of hypoxia. Herpes stromal keratitis (HSK) is a corneal chronic inflammatory condition that develops in response to recurrent HSV-1 infection. In this study, we investigated the development of hypoxia, the expression of hypoxia-associated glycolytic genes in HSV-1 infected corneas, and the outcome of blocking hypoxia-inducible factor (HIF) dimerization on the severity of HSK. Read More

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December 2018

Estimation of refractive index for biological tissue using micro-optical coherence tomography.

IEEE Trans Biomed Eng 2018 Dec 10. Epub 2018 Dec 10.

The refractive index of biological tissue is required for investigating the tissue's optical properties. Efforts have been made to characterize refractive indices of biological tissues at a single wavelength, but it is more convenient to know the Cauchy's coefficients, which provide refractive index over a wide range of wavelengths. We demonstrate a method to noninvasively provide the Cauchy's dispersion coefficients of biological tissues using micro-optical coherence tomography. Read More

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December 2018

A proteomic approach to identify novel disease biomarkers in LCAT deficiency.

J Proteomics 2018 Dec 6. Epub 2018 Dec 6.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Italy. Electronic address:

Genetic LCAT deficiency is a rare recessive autosomal disease due to loss-of-function mutations in the gene coding for the enzyme lecithin:cholesterol acyltransferase (LCAT). Homozygous carriers are characterized by corneal opacity, haemolytic anaemia and renal disease, which represent the first cause of morbidity and mortality in these subjects. Diagnostic and prognostic markers capable of early detecting declining kidney function in these subjects are not available, and the specific serum or urine proteomic signature of LCAT deficient carriers has never been assessed. Read More

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December 2018

Automated Detection of the Stromal Demarcation Line using Optical Coherence Tomography in Keratoconus Eyes after Corneal Crosslinking.

Am J Ophthalmol 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, American University of Beirut Medical Center, Beirut, Lebanon; Department of Computer Science, American University of Beirut, Beirut, Lebanon.

Purpose: To evaluate the role of a novel automated detection software as compared to human operators in assessing the presence and depth of stromal demarcation line on optical coherence tomography (OCT) in keratoconus eyes post cross-linking Design: This was a reliability analysis study.

Methods: Two independent operators and an automated detection software examined corneal OCTs of 25 eyes of 25 patients post corneal cross-linking using the Dresden protocol, at 3 months postoperatively. Operators evaluated the presence of the demarcation line and measured its depth by looking at OCT images (128 cuts) on two separate occasions one week apart. Read More

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December 2018

VIP modulates the ALX/FPR2 receptor axis toward inflammation resolution in a mouse model of bacterial keratitis.

Prostaglandins Other Lipid Mediat 2018 Dec 4;140:18-25. Epub 2018 Dec 4.

Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, United States. Electronic address:

Vasoactive intestinal peptide (VIP) has been shown to regulate corneal inflammation. Formyl peptide receptor 2 (FPR2) is a transmembrane protein belonging to the GPCR family. Ligands include pro-resolving lipids, lipoxin A4 (LXA4) and resolvin D1 (RvD1). Read More

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December 2018

Corneal involvement due to Erdheim-Chester disease.

Rev Clin Esp 2018 Oct 24. Epub 2018 Oct 24.

Servicio de Neumología, Hospital Universitario de Vic, Vic, Barcelona, España.

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October 2018

Changes in aqueous oxidative stress, prostaglandins, and cytokines: Comparisons of low-energy femtosecond laser-assisted cataract surgery versus conventional phacoemulsification.

J Cataract Refract Surg 2018 Dec 5. Epub 2018 Dec 5.

From the Cornea and Refractive Surgery Group (Liu, Setiawan, Ang, Yam, Mehta), Eye Research Institute, the Singapore National Eye Centre (Liu, Ang, Mehta), and the Duke-NUS Medical School (Liu, Yam, Mehta), Singapore. Electronic address:

Purpose: To compare the aqueous oxidative stress, prostaglandin E (PGE), and cytokine levels after low-energy femtosecond laser-assisted cataract surgery versus conventional phacoemulsification, and to evaluate the effect of a nonsteroidal antiinflammatory drug (NSAID) on the aqueous profiles.

Setting: Singapore National Eye Center, Singapore.

Design: Randomized controlled trial. Read More

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December 2018

Toxic corneal reaction due to exposure to palytoxin.

Arch Soc Esp Oftalmol 2018 Dec 5. Epub 2018 Dec 5.

Departamento Oftalmología, Hospital Universitario Mútua de Terrassa, Terrassa, España.

A case is presented of corneal toxicity after exposure to palytoxin. A 42 year-old man came with symptoms of pain and blurred vision in his right eye. He reported that a zoanthid coral from a saltwater aquarium had squirted into his eye. Read More

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December 2018

Management of advanced ocular surface disease in patients with severe atopic keratoconjunctivitis.

Ocul Surf 2018 Dec 4. Epub 2018 Dec 4.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address:

Aim & Objective: Severe ocular surface disease, including limbal stem cell deficiency (LSCD) can occur as a consequence of severe atopic keratoconjunctivitis (AKC) that has been inadequately treated. Our goal was to describe the management and outcomes of severe ocular surface disease in AKC patients.

Methods: We performed a retrospective analysis of a case series of 13 eyes of 8 patients with advanced ocular surface disease associated with severe AKC. Read More

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December 2018

Medetomidine-ketamine-sevoflurane anaesthesia in juvenile Nile crocodiles (Crocodylus niloticus) undergoing experimental surgery.

Vet Anaesth Analg 2018 Sep 19. Epub 2018 Sep 19.

Department of Clinical Sciences and Services, The Royal Veterinary College, Hatfield, UK. Electronic address:

Objective: To describe the anaesthetic, physiological and side effects of intramuscular (IM) medetomidine and ketamine, followed by inhalational anaesthesia with sevoflurane, in Nile crocodiles (Crocodylus niloticus).

Study Design: Observational trial.

Animals: Ten juvenile captive-bred Nile crocodiles undergoing surgical implantation of skeletal beads and muscular electrodes. Read More

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September 2018

Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions?

Authors:
Jason R West

Ann Emerg Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Emergency Medicine, Lincoln Medical and Mental Health Center, Bronx, NY.

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December 2018

Haptic tuck for reverse optic capture of a single-piece acrylic toric or other single-piece acrylic intraocular lenses.

J Cataract Refract Surg 2018 Dec 6. Epub 2018 Dec 6.

From Gimbel Eye Center, Calgary, Alberta, Canada. Electronic address:

We describe a new technique for capsule fixation of 1-piece acrylic toric intraocular lens (IOL) or other 1-piece acrylic IOLs in the presence of a large posterior capsule tear resulting in an open capsule. To keep the thick haptics out of the sulcus, reverse optic capture is necessary, with the haptics below the capsule and the optic edges above the capsule. This is done by placing the IOL in the sulcus and if it is a toric IOL, with the toric marks on the optic aligned with the corneal marks. Read More

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December 2018