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J Pers Med 2022 May 25;12(6). Epub 2022 May 25.

Ophthalmology Department, University Hospital, 42000 Saint-Etienne, France.

Background-The COVID-19 pandemic has changed our standard practices: operating rooms were only available for functional emergencies and outpatient visits were drastically reduced in favor of telemedicine. Aim: To report the personalized "one-shot" surgery using absorbable 10-0 Vicryl (V10-0) or polyglactin 910 monofilament in mechanical corneal injuries from February 2020 to December 2021. Methods-Prospective case series with at least 12-months' follow-up, in a French university hospital. Read More

Carbohydr Polym 2022 Sep 27;292:119668. Epub 2022 May 27.

Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan; Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan. Electronic address:

The functional design of scaffolding biomaterials with potent capabilities of promoting cell adhesion and proliferation is critically important for tissue repair and regeneration. Here, we exploit the effects of oxidation level of aldehyde hyaluronic acid (oHA) on gelatin microcarriers for repairing corneal injuries. Specifically, high oxidation levels can endow the microcarrier surface with large oHA grafting amount, smooth topography, and strong stiffness, consequently formulating biocompatible scaffolding materials with superior affinities for keratocyte attachment and growth. Read More

Ann Transl Med 2022 May;10(10):589

Department of Ophthalmology, Beijing New Vision Ophthalmology Hospital, Beijing, China.

Background: Seawater immersion complicates injuries suffered during maritime conflicts and eye injury is one of most common injuries on the battlefield. This study aimed to delineate the pathophysiological changes in the cornea after corneal injury combined with seawater immersion.

Methods: The left eye of New Zealand White rabbits was injured with firecracker and a 3-mm long whole-layer incision in the center of the cornea parallel to the corneal limbus, followed by seawater immersion. Read More

J Maxillofac Oral Surg 2022 Jun 3;21(2):386-395. Epub 2020 Sep 3.

Department of Oral and Maxillofacial Surgery, Vydehi Institute of Dental Sciences and Research Centre, Bangalore, India.

Background And Objectives: Trauma to the maxillofacial region is usually associated with varying degrees of disruption of the soft and hard tissues in the region and injuries to the neighbouring structures such as eyes, brain, nasal apparatus and paranasal sinuses. Injuries to the middle third of the face commonly destroys the integrity of the orbital skeleton, and are frequently complicated by injury to the eye, ranging between 2.7 and 67% as reported in the literature. Read More

Clin Med Insights Case Rep 2022 7;15:11795476221103824. Epub 2022 Jun 7.

Saudi Arabia Eye Consultants Hospital, Jeddah, Saudi Arabia.

Purpose: To report a rare incidence of corneal endothelial cell loss following airbag injury.

Observation: A 27-year-old female who sustained a motor vehicle accident with airbag deployment presented with hand motion vision in the left eye. Ocular examination demonstrated corneal abrasion, significant corneal stromal edema with descemet folds, and a central pachymetry of 999 µm. Read More

Adv Funct Mater 2022 Jun 8;32(24). Epub 2022 Mar 8.

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago; Chicago, Illinois, USA.

Corneal injuries are a major cause of blindness worldwide. To restore corneal integrity and clarity, there is a need for regenerative bio-integrating materials for in-situ repair and replacement of corneal tissue. Here, we introduce Light-curable COrnea Matrix (LC-COMatrix), a tunable material derived from decellularized porcine cornea extracellular matrix containing un-denatured collagen and sulfated glycosaminoglycans. Read More

Exp Eye Res 2022 Jun 7;221:109127. Epub 2022 Jun 7.

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

One of the most prevalent eye disorders is dry eye disease (DED), described by ocular dryness due to the tear insufficiency. Prolonged dry eye causes damage and ulcer to the surface of the cornea. The core of the DED mechanism is inflammation which is a biological response of the body to pathogens. Read More

Int J Mol Sci 2022 May 25;23(11). Epub 2022 May 25.

Department of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.

Communication between cells and the microenvironment is a complex, yet crucial, element in the development and progression of varied physiological and pathological processes. Accumulating evidence in different disease models highlights roles of extracellular vesicles (EVs), either in modulating cell signaling paracrine mechanism(s) or harnessing their therapeutic moiety. Of interest, the human cornea functions as a refractive and transparent barrier that protects the intraocular elements from the external environment. Read More

Mucosal Immunol 2022 Jun 9. Epub 2022 Jun 9.

International Ocular Surface Research Center, Institute of Ophthalmology, and Key Laboratory for Regenerative Medicine, Jinan University, Guangzhou, China.

Timely initiation and termination of inflammatory response after corneal epithelial abrasion is critical for the recovery of vision. The cornea is innervated with rich sensory nerves with highly dense TRPV1 nociceptors. However, the roles of TRPV1 sensory neurons in corneal inflammation after epithelial abrasion are not completely understood. Read More

West J Emerg Med 2022 Mar 24;23(3):424-431. Epub 2022 Mar 24.

Nemours Children's Hospital, Division of Neurosurgery, Wilmington, Delaware.

Introduction: The use of the emergency department (ED) has been increasing, and many visits occur for non-urgent conditions. A similar trend was found among adult visits to the ED for ocular conditions. In this study we analyzed the impact of sociodemographic factors, presentation timing, and the COVID-19 pandemic on pediatric ED (PED) encounters for ophthalmologic conditions. Read More

Prog Retin Eye Res 2022 May 29:101090. Epub 2022 May 29.

GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnatka, India.

The cornea is a specialized, transparent, avascular, immune-privileged, and heavily innervated tissue that affords 2/3rd of refraction to the eye. Ocular injuries, infections, and genetic factors affect corneal function and cause vision impairment. Presently, a variety of laser/non-laser surgeries, immunosuppressants, and/or corneal transplants are predominantly used to revive sight in human patients. Read More

Indian J Ophthalmol 2022 Jun;70(6):2210

Sankara Nethralaya, Chennai, Tamil Nadu, India.

Background: The video shows the meticulous repair of the corneoscleral tear along with management of the choroidal prolapse.

Purpose: The video demonstrates the steps to establish the anatomical integrity of the globe and tips to avoid suture bites through the choroid in a corneo-scleral tear repair.

Synopsis: Identification of important landmarks helps in the establishment of anatomical integrity. Read More

Indian J Ophthalmol 2022 Jun;70(6):2210

Ocular Trauma Service, Drashti Netralaya, Dahod, Gujarat, India.

Background: Open globe injury is a serious sight threatening condition. Full-thickness, non-selfsealing corneal lacerations require repair in the operating room. During repair, debridement of the wound is an important step. Read More

Cochrane Database Syst Rev 2022 05 27;5:CD014617. Epub 2022 May 27.

Department of public health, General Directorate of Health Affairs Aseer Region, Abha, Saudi Arabia.

Background: Corneal abrasion is a common disorder frequently faced by ophthalmologists, emergency physicians, and primary care physicians. Ocular antibiotics are one of the management options for corneal abrasion. A comprehensive summary and synthesis of the evidence on antibiotic prophylaxis in traumatic corneal abrasion is thus far unavailable, therefore we conducted this review to evaluate the current evidence regarding this important issue. Read More

Am J Ophthalmol 2022 May 23. Epub 2022 May 23.

Department of Odontostomatologic and Maxillofacial Sciences, Head and Neck Department, Sapienza University of Rome, Italy.

Purpose: To describe clinical, anatomical, and visual outcomes obtained from a long-term follow-up of 59 patients who underwent osteo-odonto-keratoprosthesis (OOKP) using the original Strampelli technique.

Design: retrospective clinical cohort study.

Methods: 82 eyes of 59 patients who underwent OOKP surgery between 1969 and 2011 were included. Read More

Ann Plast Surg 2022 Jun 18;88(6):606-611. Epub 2022 Feb 18.

From the Department of Plastic and Reconstructive Surgery, Xijing Hospital, Forth Military Medical University, Xi'an, Shaanxi, China.

Background: Fifty percent of Asians are born without a supratarsal fold (also called single eyelid), and double eyelid blepharoplasty is one of the most commonly performed and most popular facial cosmetic surgeries in the Asian population. However, patients with single eyelid frequently present with concomitant mild blepharoptosis (degree of ptosis, ≤2 mm), which often fails to cause the attention of surgeons and misses correction.

Methods: A retrospective study of all patients who underwent double eyelid blepharoplasty and blepharoptosis correction simultaneously with the modified levator aponeurosis plication technique was performed from June of 2017 to June of 2020. Read More

J Tissue Eng Regen Med 2022 May 18. Epub 2022 May 18.

Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.

Cornea as the outermost layer of the eye is at risk of various genetic and environmental diseases that can damage the cornea and impair vision. Corneal transplantation is among the most applicable surgical procedures for repairing the defected tissue. However, the scarcity of healthy tissue donations as well as transplantation failure has remained as the biggest challenges in confront of corneal grafting. Read More

Eye Contact Lens 2022 Jul 17;48(7):295-299. Epub 2022 May 17.

Department of Ophthalmology, Ege University Hospital, Izmir, Turkey.

Objectives: To report demographic characteristics, types and grades of injury, regional distribution of injury severity, clinical findings, and long-term results of acute ocular chemical burns.

Methods: Medical records of patients with chemical burns between 2010 and 2020 who were admitted to Ege University less than 72 hr after the injury were reviewed. Age, gender, cause of the burn, injury severity, initial and final best-corrected visual acuity, surgical intervention, and complications were recorded. Read More

Int Ophthalmol 2022 May 17. Epub 2022 May 17.

Department of Ophthalmology, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey.

Purpose: To investigate clinical features and factors affecting visual prognosis after pediatric open-globe injuries.

Methods: Retrospective study of 223 children with open-globe injury was conducted. Children with final logMAR visual acuity (LVA) > 0. Read More

J Vis Exp 2022 05 2(183). Epub 2022 May 2.

Department of Biology, Illinois Wesleyan University;

Chick embryonic corneal wounds display a remarkable capacity to fully and rapidly regenerate, whereas adult wounded corneas experience a loss of transparency due to fibrotic scarring. The tissue integrity of injured embryonic corneas is intrinsically restored with no detectable scar formation. Given its accessibility and ease of manipulation, the chick embryo is an ideal model for studying scarless corneal wound repair. Read More

Exp Eye Res 2022 Jul 13;220:109111. Epub 2022 May 13.

International Ocular Surface Research Center, Institute of Ophthalmology, Key Laboratory for Regenerative Medicine, Jinan University Medical School, Guangzhou, China; Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, China. Electronic address:

Purpose: Thyroid hormones have a critical role in maintaining metabolic and physiological homeostasis. However, understanding of the possible effects of thyroid dysfunction on corneal homeostasis and the wound healing process is quite limited. To explore the influence of hypothyroidism on corneal homeostasis and the post-wound repair processes of the murine cornea. Read More

Acta Biomater 2022 Jul 10;146:159-176. Epub 2022 May 10.

Aier Eye Institute, Changsha, Hunan Province, China; Aier School of Ophthalmology, Central South University, Changsha, Hunan, China; Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China. Electronic address:

Corneal nerve wounding often causes abnormalities in the cornea and even blindness in severe cases. In this study, we construct a dorsal root ganglion-corneal stromal cell (DRG-CSC, DS) co-culture 3D model to explore the mechanism of corneal nerve regeneration. Firstly, this model consists of DRG collagen grafts sandwiched by orthogonally stacked and orderly arranged CSC-laden plastic compressed collagen. Read More

NanoImpact 2021 10 24;24:100352. Epub 2021 Aug 24.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California - Davis, Davis, CA 95616, USA; Department of Ophthalmology and Vision Science, School of Medicine, University of California, Davis, CA 95616, USA. Electronic address:

Silver nanoparticles (AgNPs) are a common antimicrobial additive for a variety of applications, including wound care. However, AgNPs often undergo dissolution resulting in release of silver ions, with subsequent toxicity to mammalian cells. The cornea is a primary exposure site to topically administered AgNPs in and around the eye but their impact on corneal wound healing is understudied. Read More

Regen Med 2022 06 12;17(6):375-388. Epub 2022 May 12.

Department of Ophthalmology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, 325000, China.

This study aimed to explore the role of hypoxic mesenchymal stem cells (MSCs) in corneal alkali burns and the underlying mechanism. Rat corneal fibroblasts were incubated with IL-6, followed by treatment with hypoxic MSC supernatant. A rat corneal alkali burn model was implemented and processed with hypoxic MSCs. Read More

Am J Ophthalmol Case Rep 2022 Jun 29;26:101561. Epub 2022 Apr 29.

Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, USA.

Purpose: PVC is a synthetic plastic polymer used worldwide for a wide range of applications. While it is often associated with ocular trauma, little is known regarding how PVC may interact with ocular tissues. Herein we report the clinical course of a patient with polyvinyl chloride (PVC) embedded in the cornea after a projectile injury, utilizing anterior segment optical tomography to study the relative antigenicity and reactivity of this industrial material in the cornea. Read More

Cell Commun Signal 2022 05 6;20(1):59. Epub 2022 May 6.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.

Background: Apoptosis signal-regulating kinase 1-interacting protein 1 (AIP1) participates in inflammatory neovascularization induction. NADPH oxidase 4 (NOX4) produces reactive oxygen species (ROS), leading to an imbalance in nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) and NLR family pyrin domain containing 6 (NLRP6) expression. The mechanisms of AIP1, NOX4, ROS and inflammasomes in corneal neovascularization were studied herein. Read More

Ocul Immunol Inflamm 2022 May 6:1-4. Epub 2022 May 6.

Department of Ophthalmology, College of Medicine, King Saud University.

Background: To study the efficacy of 100% medical grade Manuka honey ointment in persistent corneal epithelial defects (CEDs).

Methods: Case series.

Results: Case 1 was a 25-year-old female patient who presented to the cornea clinic with a persistent CED (3. Read More

Am J Ophthalmol Case Rep 2022 Jun 29;26:101567. Epub 2022 Apr 29.

University of Florida Health Shands Hospital, And all authors are affiliated with the University of Florida Health Shands Hospital, located at 1600 SW Archer Rd, Gainesville, FL, 32608, United States.

The importance of protective eyewear during activities which involve high velocity projectiles is often emphasized to patients, however the material and design of such eyewear is also important. We present the case of a boy who sustained ocular injury from a plastic airsoft bullet while wearing a protective mask issued by the manufacturer. The patient was found to have decreased vision, a corneal abrasion and hyphema. Read More

Indian J Ophthalmol 2022 05;70(5):1475-1490

Cornea, Lens and Refractive Surgery Services, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute for Medical Sciences, New Delhi, India.

Infectious keratitis is a medical emergency resulting in significant visual morbidity. Indiscriminate use of antimicrobials leading to the emergence of resistant or refractory microorganisms has further worsened the prognosis. Coexisting ocular surface diseases, delay in diagnosis due to inadequate microbiological sample, a slow-growing/virulent organism, or systemic immunosuppressive state all contribute to the refractory response of the ulcer. Read More