Search Our Scientific Publications & Authors

J Cataract Refract Surg 2021 May 10. Epub 2021 May 10.

Tane Memorial Eye Hospital(Sachiko Fukuoka, MD, Taiga Kinoshita, MD, Toshiya Sakurai, MD) Aoba Eye Clinic(Shinichi Morita, MD).

Abstract: Current intraocular lens (IOL) explantation techniques are limited to cutting the optic and removing the pieces through a small incision, or folding single piece acrylic IOLs using a two-handed technique. Poor execution of IOL explantation can result in injury to intraocular structures, including the corneal endothelium and iris. The minimally invasive "cartridge pull-through technique" was invented, using a cartridge for IOL implantation and novel forceps optimized for secure grasping of the IOL for removal. Read More

Ophthalmologe 2021 Jun 9. Epub 2021 Jun 9.

Klinik und Poliklinik für Augenheilkunde, Charité - Universitätsmedizin Berlin, Berlin Institute of Health, Freie Universität Berlin, Humboldt-Universität zu Berlin, Augustenburger Platz 1, Berlin, 13353, Deutschland.

The cornea forms the anterior border of the eye and significantly contributes to a sharp optical image quality on the retina through its transparency, avascular nature and curvature. Because of its anatomical structure and as a barrier to the environment, the cornea is particularly exposed to various external factors, such as injuries and pathogens. A correct wound healing without the formation of light diverging scarring is therefore essential to preserve the integrity and function of the cornea. Read More

Cells 2021 May 19;10(5). Epub 2021 May 19.

Centre for Ocular Regeneration, Prof. Brien Holden Eye Research Centre, Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory, Hyderabad Eye Research Foundation, L.V. Prasad Eye Institute, Hyderabad 500034, India.

Corneal injuries are among the leading causes of blindness and vision impairment. Trauma, infectious keratitis, thermal and chemical (acids and alkali burn) injuries may lead to irreversible corneal scarring, neovascularization, conjunctivalization, and limbal stem cell deficiency. Bilateral blindness constitutes 12% of total global blindness and corneal transplantation remains a stand-alone treatment modality for the majority of end-stage corneal diseases. Read More

Animals (Basel) 2021 May 11;11(5). Epub 2021 May 11.

Department of Veterinary Medicine and Animal Production, Unit of Food Hygiene, University of Naples Federico II, Via F. Delpino 1, 80137 Napoli, Italy.

Water-bath stunning represents the most-applied stunning system in poultry slaughtering, but within the European Union, specific indications on electric parameters that should be used, such as voltage, are missing. The objective of this study was to evaluate the efficiency of two commercially available types of electrical equipment (A and B) on broilers with different live body weights and the influence of the tested parameters on meat quality. Experimental trials in a European Union-approved slaughterhouse were carried out using two different stunners. Read More

Int J Pharm 2021 May 24;604:120732. Epub 2021 May 24.

Medway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building Central Avenue, Chatham, Kent, ME4 4TB, United Kingdom.

The treatment of corneal abrasion currently involves the topical administration of antibiotics, with moxifloxacin HCl (0.5% w/v) eye drops being one of the most widely used treatments. Our previous work (Tawfik et al. Read More

J Intensive Care Soc 2021 May 31;22(2):136-142. Epub 2020 Mar 31.

Randomized Controlled Trial Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.

Background: High prevalence of ocular surface disorders includes eye dryness and corneal ulcer among intensive care unit patients remains an issue. This study aimed to compare the effectiveness of Lubratex ointment and vitamin A eye ointment in preventing ocular surface disorders in intensive care unit patients.

Methods: A single-center randomized clinical trial was conducted in critically ill patients of vitamin A eye ointment and Lubratex ointment in preventing ocular surface disorders. Read More

Int Med Case Rep J 2021 14;14:327-332. Epub 2021 May 14.

Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.

Infectious and traumatic corneal diseases require adequate therapy against infection and promote re-epithelialization. The appearance of multidrug-resistant bacterial strains, induced by excessive use of antibiotics in the treatment of infectious diseases, has urged researchers to study new antimicrobial formulations. Ozonated oils have demonstrated antiseptic (antibacterial, antifungal and antiviral) and reparative properties and can be proposed for the prevention and treatment of acute and chronic local infections, as an alternative to conventional topical antimicrobials. Read More

Med Pharm Rep 2021 Apr 29;94(2):131-144. Epub 2021 Apr 29.

Department of Ophthalmology, University Hospital of Heraklion, Crete, Greece.

Purpose: This review provides literature views on ocular trauma, with emphasis on common causes of injury, occupational risk, socio-economic factors, management peculiarities and some implications on overall care approach, from prevention to treatment.

Methods: A literature search was performed using key words in PubMed to extract the most relevant articles on ocular injuries, from an occupational point of view. Seventeen relevant articles were included out of seventy-two. Read More

Bioact Mater 2021 Dec 5;6(12):4447-4454. Epub 2021 May 5.

Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Corneal injuries will cause corneal surface diseases that may lead to blindness in millions of people worldwide. There is a tremendous need for biomaterials that can promote corneal regeneration with practical feasibility. Here we demonstrate a strategy of a protein coating for corneal injury regeneration. Read More

Clin Ophthalmol 2021 6;15:1639-1645. Epub 2021 May 6.

Cornea and External Eye Disease Service, Moorfields Eye Hospital, London, UK.

Purpose: Moorfields Eye Hospital sits as a major tertiary centre for ophthalmic care in the United Kingdom and became a central hub to provide safe and effective ophthalmic care across London and surrounding regions during the COVID-19 pandemic. We explore the impact on both the acute and elective corneal services during the first wave of this pandemic.

Methods: A retrospective review of the proportion of corneal transplants and anterior segment trauma repairs was performed during the period of March 23rd to July 1st 2020 compared with an identical period in 2019. Read More

JAMA 2021 05;325(18):1912

Department of Ophthalmology, University of Florida College of Medicine, Gainesville.

Mil Med 2021 May 7. Epub 2021 May 7.

Department of Sensory Trauma, United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA.

Introduction: Open-globe ocular injuries have increased in frequency in recent combat operations due to increased use of explosive weaponry. Unfortunately, open-globe injuries have one of the worst visual outcomes for the injured warfighter, often resulting in permanent loss of vision. To improve visual recovery, injuries need to be stabilized quickly following trauma, in order to restore intraocular pressure and create a watertight seal. Read More

Cont Lens Anterior Eye 2021 May 1:101452. Epub 2021 May 1.

Section of Pediatric Ophthalmology, Department of Ophthalmology, Emory University School of Medicine, 1365B Clifton Road, NE, Suite 5400, Atlanta, GA, 30322, United States.

Purpose: To report the use of a custom-designed, scleral contact lens (SL) in the treatment of pediatric patients.

Methods: The medical records of all patients under 15 years of age fitted with SL from March 2018 through February 2020 were retrospectively reviewed. Ophthalmic diagnosis, prior surgical intervention, lens wearing failures, and duration of lens use are reported. Read More

Klin Monbl Augenheilkd 2021 04 30;238(4):367-368. Epub 2021 Apr 30.

Augenklinik, Universitätsspital Basel, Schweiz.

Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.

Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, Poland.

The cornea, while appearing to be simple tissue, is actually an extremely complex structure. In order for it to retain its biomechanical and optical properties, perfect organization of its cells is essential. Proper regeneration is especially important after injuries and in the course of various diseases. Read More

Biomolecules 2021 Apr 2;11(4). Epub 2021 Apr 2.

Brien Holden Eye Research Center, LV Prasad Eye Institute, Hyderabad, Telangana 500034, India.

Biological materials derived from extracellular matrix (ECM) proteins have garnered interest as their composition is very similar to that of native tissue. Herein, we report the use of human cornea derived decellularized ECM (dECM) microparticles dispersed in human fibrin sealant as an accessible therapeutic alternative for corneal anterior stromal reconstruction. dECM microparticles had good particle size distribution (≤10 µm) and retained the majority of corneal ECM components found in native tissue. Read More

Indian J Ophthalmol 2021 05;69(5):1052-1060

Aberdeen Royal Infirmary, NHS Grampian, Scotland.

The incidence of leishmaniasis is reported to be up to 1 million per year. To date, there has been no comprehensive review describing the diversity of clinical presentations of ocular leishmaniasis (OL) and its treatment. This systematic review aims to address this knowledge gap and provide a summary of the clinical presentation, natural course, and treatment options for OL. Read More

Small 2021 Apr 22:e2006335. Epub 2021 Apr 22.

Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, 1449614535, Iran.

Hydrogel biomaterials have many favorable characteristics including tuneable mechanical behavior, cytocompatibility, optical properties suitable for regeneration and restoration of the damaged cornea tissue. The cornea is a tissue susceptible to various injuries and traumas with a complicated healing cascade, in which conserving its transparency and integrity is critical. Accordingly, the hydrogels' known properties along with the stimulation of nerve and cell regeneration make them ideal scaffold for corneal tissue engineering. Read More

Klin Monbl Augenheilkd 2021 Apr 19. Epub 2021 Apr 19.

Keratoconus leads to a progressive protrusion and thinning of the cornea. In order to stop this, corneal crosslinking can be performed if the progression of the disease is proven. Crosslinking according to the "Dresden protocol" includes abrasion of the corneal epithelium, application of riboflavin eye drops and irradiation with UV-A light of an intensity of 3 mW/cm² for 30 minutes. Read More

Digit J Ophthalmol 2021 Feb 12;26(4):31-35. Epub 2020 Oct 12.

Department of Ophthalmology, Massachusetts Eye and Eye Infirmary, Harvard Medical School, Boston, Massachusetts.

Purpose: To describe the utilization trends of a dedicated ophthalmology emergency department (ED) in Boston, Massachusetts.

Methods: The medical records of 500 randomly selected patients who presented at the Massachusetts Eye and Ear (MEE) Emergency Department (ED) from January 2015 to March 2016 were reviewed retrospectively. Data were analyzed using the Pearson χ2 test and multiple logistic regression. Read More

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Vitreoretina Services, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.

Siderotic glaucoma is a rare and challenging clinical scenario caused by a retained iron intraocular foreign body (IOFB), which results in irreversible vision loss. Presented here is a case of secondary open-angle glaucoma in a 36-year-old man that was refractory to maximal medical therapy. A meticulous history and careful clinical examination revealed that he had a penetrating trauma 15 years ago, a self-sealed corneal entry wound, open angles, a retained encapsulated metallic IOFB and siderosis bulbi. Read More

Int J Surg Case Rep 2021 May 1;82:105856. Epub 2021 Apr 1.

Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.

Introduction And Importance: Ocular injury is second mostly caused by motor vehicle accident (MVA) and often leads to severe ocular injury even to visual loss and various aesthetic problems. The outcome is determined by the magnitude of the initial damage and treatment availability. Treating ocular and facial injury due to MVA is challenging given the scope of the damage and may result in various outcomes. Read More

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

This is a case of a 17-year-old patient with aniridia-related keratopathy and persistent epithelial defect (PED) treated successfully using maternal finger-prick blood (FPB). Maternal allogenic FPB treatment was initiated to the patient who was non-compliant with the use of autologous FPB. The PED was successfully managed with maternal FPB treatment with rapid and complete closure of the epithelial defect. Read More

Proc Natl Acad Sci U S A 2021 Mar;118(11)

School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 37673 Pohang, Republic of Korea;

Ultrasound and optical imagers are used widely in a variety of biological and medical applications. In particular, multimodal implementations combining light and sound have been actively investigated to improve imaging quality. However, the integration of optical sensors with opaque ultrasound transducers suffers from low signal-to-noise ratios, high complexity, and bulky form factors, significantly limiting its applications. Read More

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, TX 78234, USA.

Introduction: American military personnel in U.S. Africa Command (AFRICOM) operate in a continent triple the size of the USA without mature medical facilities, requiring a substantial transportation network for medical evacuation. Read More

Invest Ophthalmol Vis Sci 2021 Apr;62(4)

Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States.

Purpose: Interleukin (IL)-1α/IL-1β and transforming growth factor (TGF)β1/TGFβ2 have both been promoted as "master regulators" of the corneal wound healing response due to the large number of processes each regulates after injury or infection. The purpose of this review is to highlight the interactions between these systems in regulating corneal wound healing.

Methods: We conducted a systematic review of the literature. Read More

Cont Lens Anterior Eye 2021 Apr 25;44(2):330-367. Epub 2021 Mar 25.

School of Optometry, Aston University, Birmingham, UK.

Contact lens-related complications are common, affecting around one third of wearers, although most are mild and easily managed. Contact lenses have well-defined anatomical and physiological effects on the ocular surface and can result in other consequences due to the presence of a biologically active material. A contact lens interacts with the tear film, ocular surface, skin, endogenous and environmental microorganisms, components of care solutions and other antigens which may result in disease specific to contact lens wear, such as metabolic or hypersensitivity disorders. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 11;255:119667. Epub 2021 Mar 11.

Singapore Eye Research Institute, Singapore; Singapore National Eye Centre, Singapore; Ophthalmology and Visual Science Academic Clinical Research Program, Duke-NUS Medical School, Singapore. Electronic address:

Pulsed terahertz (THz) broadband spectroscopy and imaging were applied to investigate ex vivo rabbit corneal scar tissues. Scars with different depths and densities were created by laser ablation on four corneal samples while two corneal samples untouched were used as control. The THz time-domain spectroscopy and reconstructed images illustrated the scar tissue density and gave out depth variation distribution profiles. Read More

Stem Cells Int 2021 7;2021:6610023. Epub 2021 Mar 7.

Laboratory of Experimental Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

To assess effects of adipose-derived mesenchymal stem cells (AMSCs) in corneal alkali injuries in an experimental animal model. Twenty white New Zealand rabbits were included in the study. The animal models were randomly divided into 2 groups. Read More