6,912 results match your criteria Cornea[Journal]


Effect of Optisol Supplementation With 0.255 μg/mL Amphotericin B on Elimination of Yeast at 5°C.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Department of Ophthalmology, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA.

Purpose: Fungal infections in lamellar keratoplasty are a growing concern. Optisol-GS does not contain an antifungal agent and supplementation with 0.255 μg/mL Amphotericin B (AmpB) has been considered. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001969DOI Listing
April 2019
3 Reads

Microbial Keratitis in Stevens-Johnson Syndrome: A Prospective Study.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To evaluate the microbiological profile and outcome in cases with infective keratitis in Stevens-Johnson syndrome (SJS).

Methods: Eighty-three eyes of 68 patients with SJS presenting with microbial keratitis were recruited and managed with standard antimicrobial therapy.

Results: Microbial keratitis developed in 34% of patients with SJS (83 eyes, 68 patients) over a period of 5 years. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001960DOI Listing
April 2019
1 Read

Corneal Tomography Changes and Refractive Outcomes After Descemet Stripping Without Endothelial Keratoplasty.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.

Purpose: To investigate corneal tomography changes and refractive outcomes after Descemetorhexis without endothelial keratoplasty (DWEK).

Methods: Retrospective chart review of 25 eyes from 16 patients with Fuchs corneal endothelial dystrophy that underwent successful DWEK combined with cataract surgery.

Results: There was no significant change in anterior corneal curvature on tomography maps. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001896DOI Listing

Expressible Meibomian Glands Have Occult Fixed Obstructions: Findings From Meibomian Gland Probing to Restore Intraductal Integrity.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Dry Eye and Cornea Treatment Center, Tampa, FL.

Purpose: To describe and quantify findings of intraductal obstruction during probing expressible and nonexpressible meibomian glands (MGs) in patients with obstructive meibomian gland dysfunction using a 1-mm intraductal MG probe.

Methods: A retrospective study of probe findings from 108 consecutive patients. Nonparametric tests using SPSS software 25. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001954DOI Listing

Implementation of a Quality Index for Improvement of Quantification of Corneal Nerves in Corneal Confocal Microcopy Images: A Multicenter Study.

Cornea 2019 Apr 11. Epub 2019 Apr 11.

University Eye Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Purpose: Corneal confocal microscopy (CCM) is an imaging method to detect loss of nerve fibers in the cornea. The impact of image quality on the CCM parameters has not been investigated. We developed a quality index (QI) with 3 stages for CCM images and compared the influence of the image quality on the quantification of corneal nerve parameters using 2 modes of analysis in healthy volunteers and patients with known peripheral neuropathy. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001949DOI Listing

Outcomes of Corneal Transplantation Using Donor Corneas Retrieved From Snakebite Victims.

Cornea 2019 Apr 9. Epub 2019 Apr 9.

Tej Kohli Cornea Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To report the outcomes of corneal transplantation using donor corneas retrieved from snakebite victims.

Methods: This study was a retrospective analysis of 30 corneal transplants performed from 2014 to 2016 using donor corneas retrieved from snakebite victims. The details of the donor corneal characteristics and the transplant recipients were collected from the eye bank and the medical records department. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001953DOI Listing
April 2019
4 Reads

Risk factors for Cystoid Macular Edema After Descemet Membrane Endothelial Keratoplasty.

Cornea 2019 Apr 9. Epub 2019 Apr 9.

Department of Ophthalmology, Jichi Medical University, Tochigi, Japan.

Purpose: To investigate factors associated with cystoid macular edema (CME) after Descemet membrane endothelial keratoplasty (DMEK) in Asian eyes.

Methods: In this retrospective, interventional, consecutive case series, 77 eyes of 65 patients who underwent DMEK were evaluated; in 53 eyes, cataract surgery was performed 1 month before DMEK (staged DMEK), and 24 eyes underwent DMEK alone (simple DMEK). Central retinal thickness, incidence of CME, postoperative best-corrected visual acuity, central corneal thickness, and corneal endothelial cell density were assessed at 1, 3, and 6 months after surgery. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001950DOI Listing
April 2019
2 Reads

Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy.

Cornea 2019 Apr 9. Epub 2019 Apr 9.

Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.

Purpose: To investigate single nucleotide polymorphisms (SNPs) and trinucleotide repeat (TNR) expansion in the transcription factor 4 (TCF4) gene in a large cohort of German patients with Fuchs endothelial corneal dystrophy (FECD).

Methods: Genomic DNA was obtained from 398 patients with FECD and from 58 non-FECD controls. Thirty-seven previously reported SNPs were evaluated by genotyping. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001952DOI Listing

Three-Year Outcome Comparison Between Femtosecond Laser-Assisted and Manual Descemet Membrane Endothelial Keratoplasty.

Cornea 2019 Apr 9. Epub 2019 Apr 9.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada.

Purpose: To evaluate 3-year outcomes of femtosecond laser-assisted Descemet membrane endothelial keratoplasty (F-DMEK) compared with manual Descemet membrane endothelial keratoplasty (M-DMEK) in patients with Fuchs endothelial corneal dystrophy (FECD).

Methods: A retrospective, interventional study, including eyes with FECD and cataract that underwent either F-DMEK or M-DMEK combined with cataract extraction at either the Toronto Western Hospital or Kensington Eye Institute, and that had at least 18 months' follow-up was conducted.

Exclusion Criteria: complicated anterior segments, previous vitrectomy, previous keratoplasty, corneal opacity, or any other visually significant ocular comorbidity. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001956DOI Listing

Corneal Evaluation in Patients With Parkinsonism on Long-Term Amantadine Therapy.

Cornea 2019 Apr 9. Epub 2019 Apr 9.

Cornea & Ocular Surface Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To evaluate the progression of corneal endothelial changes in patients with Parkinson disease (PD) on long-term oral amantadine therapy.

Methods: A prospective comparative longitudinal observational study of 90 patients (180 eyes) with PD on more than 6 months of oral amantadine therapy, 30 amantadine naive patients with PD, and 30 healthy controls (age and gender matched). Corneal endothelial cell parameters (endothelial cell density, percentage hexagonality of the cells, and coefficient of variation) and corneal subbasal nerve fiber layer changes were studied over a follow-up period of 1 year. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001951DOI Listing
April 2019
1 Read
2.360 Impact Factor

Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea.

Cornea 2019 Apr 8. Epub 2019 Apr 8.

The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN.

Purpose: We previously showed that cannabinoid-related GPR18 receptors are present in the murine corneal epithelium, but their function remains unknown. The related CB1 receptors regulate corneal healing, possibly via chemotaxis. We therefore examined a potential role for GPR18 in corneal epithelial chemotaxis and wound healing. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001934DOI Listing

Multimodal Imaging Report of Crystalline Keratopathy in Relapsing Polychondritis.

Cornea 2019 Apr 8. Epub 2019 Apr 8.

Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA.

Purpose: To describe a case of bilateral multifocal stromal crystalline keratopathy in the setting of relapsing polychondritis (RP).

Methods: Case report.

Results: We describe a 31-year-old woman who presented with ocular inflammation, bilateral auricular chondritis, and nasal chondritis, meeting the clinical criteria of RP. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001921DOI Listing
April 2019
5 Reads

Ectopic Ocular Surface Calcification in Patients With Hypophosphatasia Treated With Asfotase Alfa.

Cornea 2019 Apr 8. Epub 2019 Apr 8.

Department of Ophthalmology, Duke University Medical Center, Durham, NC.

Purpose: To assess for ectopic ocular calcification in a series of patients with hypophosphatasia (HPP) treated with asfotase alfa, a recombinant tissue-nonspecific alkaline phosphatase.

Methods: This is a retrospective analysis of subjects enrolled at Duke University Medical Center in ENB-009-10 (ClinicalTrials.gov: NCT01163149), a randomized controlled trial of asfotase alfa in adolescents and adults with HPP. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001947DOI Listing

Reply.

Cornea 2019 Apr 3. Epub 2019 Apr 3.

Department of Ophthalmology, Cantonal Hospital of Lucerne, Lucerne, Switzerland.

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http://dx.doi.org/10.1097/ICO.0000000000001943DOI Listing
April 2019
1 Read

Relationship Between the Degree of Iris Pigmentation and Corneal Sensitivity to a Cooling Stimulus.

Cornea 2019 Apr 3. Epub 2019 Apr 3.

School of Optometry & Vision Science, University of Waterloo, Waterloo, Canada.

Purpose: To explore the relationship between the degree of iris pigmentation and corneal sensitivity threshold (CST) on a variety of different ethnicities, using the air-jet noncontact corneal aesthesiometer and by applying a consistent method of subject iris pigmentation classification.

Methods: A total of 200 subjects (mean age 23.7 ± 3. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001933DOI Listing

Coincidental Occurrence of Schnyder Corneal Dystrophy and Posterior Polymorphous Corneal Dystrophy Type 3.

Cornea 2019 Apr 2. Epub 2019 Apr 2.

Research Unit for Rare Diseases First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic First Faculty of Medicine, Charles University, Prague, Czech Republic.

Purpose: To report a simultaneous occurrence of 2 rare corneal dystrophies.

Methods: A 30-year-old man with a family history of posterior polymorphous corneal dystrophy type 3 (PPCD3) was invited for ophthalmic examination. Sanger sequencing of the coding regions and intron/exon boundaries of disease-associated genes, ZEB1 and UBIAD1, was performed. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001930DOI Listing
April 2019
2 Reads

The Correlation Between Dry Eyes, Anxiety and Depression: The Sicca, Anxiety and Depression Study.

Cornea 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, University of North Carolina, Chapel Hill, NC.

Purpose: To determine whether improvement in the severity of dry eye disease (DED) symptoms correlates with improvement in anxiety and depression.

Methods: This prospective interventional case series recruited 45 adults with evidence of DED. Patients were administered the University of North Carolina Dry Eye Management Scale (DEMS), Generalized Anxiety Disorder 7-item scale (GAD-7), and Personal Health Questionnaire Depression Scale (PHQ-8) to evaluate the severity of DED symptoms, anxiety, and depression, respectively. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001932DOI Listing
April 2019
2 Reads

Corneal Edema Associated With Systemic Dopaminergic Agents.

Cornea 2019 Apr 2. Epub 2019 Apr 2.

James A Haley VA Eye Clinic.

Purpose: To describe the development and resolution of corneal edema in 3 patients who were exposed to compounds that stimulate dopaminergic pathways.

Methods: We conducted a review of the literature on bilateral corneal edema secondary to amantadine use and report a case series of corneal edema seen in an outpatient ophthalmology specialty clinic, shortly after exposure to agents that enhance dopamine transmission.

Results: Cases 1 and 2 report a 25-year-old man with attention-deficit hyperactivity disorder and a 73-year-old man with Parkinson disease who were placed on dopaminergic medications to treat their conditions. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001941DOI Listing
April 2019
1 Read

Comparison of Small Incision Lenticule Extraction Surgery With and Without Cyclotorsion Error Correction for Patients With Astigmatism.

Cornea 2019 Apr 2. Epub 2019 Apr 2.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, PR China.

Purpose: To evaluate the add-on effect of manual cyclotorsion error correction by the cornea-marking method over standard small incision lenticule extraction (SMILE) surgery in astigmatic eyes.

Methods: Consecutive patients (84) who had preoperative myopic astigmatism of -0.75 diopters (D) or more and were seeking surgical refractive correction by SMILE surgery during July 2017 to August 2017 were included in this study and randomized to treatment with standard SMILE surgery (S group: 30 eyes) or cyclotorsion compensated SMILE surgery (CC group: 54 eyes). Read More

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http://dx.doi.org/10.1097/ICO.0000000000001937DOI Listing

Bilateral Congenital Corneal Opacities as an Early-Onset Ocular Feature of Kabuki Syndrome.

Cornea 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Purpose: Kabuki syndrome (KS) is a rare congenital disorder characterized by multiple systemic anomalies and unique facial characteristics. Here, we present the first case, to the best of our knowledge, of bilateral congenital corneal opacities as an early-onset ocular manifestation of KS associated with a KMT2D gene mutation.

Methods: The proband is a girl. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001948DOI Listing
April 2019
2 Reads
2.360 Impact Factor

Reply.

Cornea 2019 Mar 29. Epub 2019 Mar 29.

Sussex Eye Hospital, Brighton and Sussex University Hospitals, NHS Trust, Brighton, United Kingdom.

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http://dx.doi.org/10.1097/ICO.0000000000001939DOI Listing
March 2019
2 Reads
2.360 Impact Factor

Management of Type 2 Bubble Formed During Big-Bubble Deep Anterior Lamellar Keratoplasty.

Cornea 2019 Mar 29. Epub 2019 Mar 29.

Department of Ophthalmology, Southend University Hospital, Southend, United Kingdom.

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http://dx.doi.org/10.1097/ICO.0000000000001940DOI Listing
March 2019
3 Reads

Comment on "Descemetorhexis Without Endothelial Keratoplasty Versus DMEK for Treatment of Fuchs Endothelial Corneal Dystrophy".

Cornea 2019 May;38(5):e14

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1097/ICO.0000000000001893DOI Listing
May 2019
3 Reads

Evaluation of the Ocular Surface in Different Contact Lens Replacement Schedules.

Cornea 2019 May;38(5):587-594

Ophthalmology Department, Diskapi Yildirim Beyazit Training and Research Hospital, Saglik Bilimleri University, Ankara, Turkey.

Purpose: To evaluate the effects of different contact lens (CL) replacement schedules and different CL materials on the ocular surface and tear function.

Methods: Daily disposable hydrogel CLs were given to group 1 (n = 22), daily disposable silicone hydrogel CLs were given to group 2 (n = 25), and reusable silicone hydrogel CLs were given to group 3 (n = 24). Tear function tests and inflammatory cytokine [interleukin (IL)-6, IL-8, IL-17A, and matrix metalloproteinase (MMP)-9] levels were evaluated before and at 1 and 3 months after CL usage. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001870DOI Listing
May 2019
2 Reads

Evaluation of Dry Eye Disease in Children With Systemic Lupus Erythematosus and Healthy Controls.

Cornea 2019 May;38(5):581-586

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Purpose: To compare the symptoms and signs of dry eye disease (DED) in children with systemic lupus erythematosus (SLE) with those in healthy children using common diagnostic tools.

Methods: Prospective, observational, single-center cohort study. Thirty-four subjects with SLE and 15 healthy subjects were recruited from the Hospital for Sick Children in Toronto, Canada. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001902DOI Listing
May 2019
2 Reads

Effect of Anti-Vascular Endothelial Growth Factor Therapy on Corneal Nerves.

Cornea 2019 May;38(5):559-564

Miami Veterans Administration Medical Center, Miami, FL.

Purpose: Vascular endothelial growth factor (VEGF) is a trophic factor for corneal nerves (CNs). Despite its widespread use to treat a variety of retinal diseases, the effect of repetitive intravitreal (IV) anti-VEGF injections on CN is not known.

Methods: Retrospective case-control study. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001871DOI Listing
May 2019
1 Read

Recent Surgical Trends in Pediatric Corneal Transplantation: A 13-Year Review.

Cornea 2019 May;38(5):546-552

Department of Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, MD.

Purpose: Corneal transplantation is the standard of care for pediatric corneal opacities, but little consensus exists on optimal surgical management. Our goal was to evaluate cross-sectional data of donor and recipient characteristics collected from eye banks providing tissue for pediatric corneal transplant cases to assess surgical trends in pediatric keratoplasty over the past 13 years.

Methods: We performed a retrospective review of recipient data, collected from 4 major eye banks, for pediatric patients (<18 years) who underwent corneal transplantation between January 2005 and December 2017. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001900DOI Listing
May 2019
2 Reads

N-chlorotaurine Inactivates Acanthamoeba and Candida albicans in the Porcine Ex Vivo Corneal Infection Model.

Cornea 2019 Mar 28. Epub 2019 Mar 28.

Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.

Purpose: N-chlorotaurine (NCT) is an anti-infective belonging to the class of chloramines and an investigative drug for the topical treatment of keratoconjunctivitis. The aim of the present study was to demonstrate its efficacy against Acanthamoeba and Candida in corneas infected ex vivo.

Methods: Corneal buttons from porcine eyes were contaminated with Acanthamoeba castellanii trophozoites or Candida albicans Centraalbureau voor Schimmelcultures 5982 and incubated for 7 and 3 days, respectively. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001927DOI Listing
March 2019
1 Read

Inferior Quadrant of Tear Film Is More Likely to Break and Breaks Early in Patients With Dry Eyes.

Cornea 2019 May;38(5):624-631

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To investigate the temporal and spatial distribution of tear film breakup time via a noninvasive topographer in normal subjects and patients with dry eye disease (DED).

Methods: A total of 77 subjects were separated into normal and DED groups based on their symptoms and tear film instabilities. In noninvasive evaluation with Oculus Keratograph, the precorneal tear film was recorded and reconstructed into a two-dimensional map that evolved with time. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001886DOI Listing

Localization of Corneal Neovascularization Using Optical Coherence Tomography Angiography.

Cornea 2019 Mar 19. Epub 2019 Mar 19.

Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China.

Purpose: This article explores the application of optical coherence tomography angiography (OCTA) in assessing corneal neovascularization (CoNV) and investigates the features of CoNV in eyes with corneal transplantation.

Methods: A pilot, case series, observational study was conducted to enroll patients who underwent corneal transplantation including penetrating keratoplasty (PKP) and deep lamellar keratoplasty (DLKP) with or without additional keratolimbal allograft transplantation. All patients were followed with a series of ophthalmologic examinations including slit-lamp photography and were then imaged with the anterior segment OCTA. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001931DOI Listing
March 2019
1 Read

Management of Ocular Allergy Itch With an Antihistamine-Releasing Contact Lens.

Cornea 2019 Mar 19. Epub 2019 Mar 19.

Andover Eye Associates, Andover, MA.

Purpose: A contact lens (CL)-based drug delivery system for therapeutic delivery of the antihistamine ketotifen was tested in 2 parallel, conjunctival allergen challenge-based trials.

Methods: Both trials employed the same multicenter, randomized, placebo-controlled protocol. Test lenses were etafilcon A with 0. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001911DOI Listing
March 2019
10 Reads

Seroprevalence of Anti-HIV-1, Anti-HIV-2, Hepatitis B Surface Antigen, and Anti-HCV in Eye Donors in a Tertiary Eye Hospital, Chennai, India, in the Past 13 years (2005-2017).

Cornea 2019 Mar 21. Epub 2019 Mar 21.

L&T Microbiology Research Centre, Vision Research Foundation, Chennai, Tamil Nadu, India.

Purpose: To understand the seroprevalence of HIV, hepatitis B surface antigen (HBsAg), and hepatitis C virus (HCV) in serum samples collected from eye donors between 2005 and 2017 at Sankara Nethralaya, Chennai, India.

Method: The reports of 7136 eye donors serologically screened for antibodies to HIV-1 and HIV-2, HBsAg, and antibodies to HCV were retrospectively analyzed.

Result: Among the 7136 serum samples screened during this study period, the serum samples of 14 donors (0. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001926DOI Listing
March 2019
1 Read
2.360 Impact Factor

Changes in Corneal Wound Healing and Graft Biomechanics After Primary Penetrating Keratoplasty Versus Repeat Penetrating Keratoplasty.

Cornea 2019 Mar 18. Epub 2019 Mar 18.

Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Purpose: To evaluate and compare the influence of the wound healing process at the graft edge on corneal biomechanics after primary penetrating keratoplasty (PK) and repeat PK.

Methods: This retrospective comparative study included 95 eyes: 35 eyes of 35 patients had PK, 40 eyes of 40 patients underwent repeat PK, and 20 eyes of 20 normal subjects served as the control group. The ocular response analyzer was used to measure and compare corneal hysteresis and corneal resistance factor among the study groups at least 6 months after all sutures were removed. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001928DOI Listing

Deep Trephination Allows High Rates of Successful Pneumatic Dissection for DALK Independent of Surgical Experience.

Cornea 2019 May;38(5):645-647

Department of Ophthalmology, Ospedale Privato "Villa Igea", Forlì, Italy.

Purpose: To evaluate the relationship between surgical experience and the success rate of pneumatic dissection for deep anterior lamellar keratoplasty (DALK) using deep trephination.

Methods: A noncomparative case series evaluating the first 10 consecutive keratoconic eyes without deep stromal scarring, operated by 8 surgeons of 3 different experience levels, was conducted; there were a total of 80 patients. Standardized DALK was performed, including deep trephination 450 to 550 μm in depth and 9 mm in diameter, pneumatic dissection, removal of the stroma, and transplantation of a 9-mm partial-thickness anterior lamellar graft. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001881DOI Listing

Fibrin Glue-Assisted Closure of Macroperforation in Predescemetic Deep Anterior Lamellar Keratoplasty With a Donor Obtained From Small Incision Lenticule Extraction.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Dr. Agarwal's Refractive and Cornea Foundation (DARCF), Chennai, India.

Purpose: To report a case with multiple macroperforations and a double anterior chamber (AC) after predescemetic deep anterior lamellar keratoplasty.

Methods: A patient was referred after undergoing complicated excision of pseudopterygium that extended onto the cornea. At presentation, an eccentric lamellar patch graft extending over the pupillary axis with a double AC was seen. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001918DOI Listing
March 2019
2.360 Impact Factor

Peripheral Endothelial Cell Density in Descemet Membrane Endothelial Keratoplasty Grafts.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN.

Purpose: To compare the variation in corneal endothelial cell density (ECD) from the center to the periphery in unpeeled and peeled donor corneas and to determine the impact of eccentric trephining on total endothelial cells in Descemet membrane endothelial keratoplasty (DMEK) grafts.

Methods: Mated donor cornea pairs were obtained. One cornea from each pair was peeled for DMEK, whereas the other was left unpeeled. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001925DOI Listing

Outcomes of a Modified Technique for Successful Pneumatic Dissection in Pediatric Eyes With Corneal Scars.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Ospedali Privati Forlì, Department of Ophthalmology, Forlì, Italy.

Purpose: To report the outcomes of a modified deep anterior lamellar keratoplasty (DALK) procedure for the treatment of scarred corneas in otherwise healthy pediatric eyes.

Methods: All pediatric eyes undergoing DALK by the same surgeon (M.B. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001924DOI Listing

Blood Vessels and Lymphatic Vessels in the Cornea and Iris After Penetrating Keratoplasty.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.

Purpose: To detect early growth of blood and lymphatic vessels in the mouse cornea and iris after penetrating keratoplasty.

Methods: Penetrating keratoplasty was performed with C57BL/6 mice as donors and BALB/c mice as recipients. Graft transparency and neovascularization were examined by slit-lamp microscopy. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001922DOI Listing
March 2019
1 Read

Successful Management of Herpes Simplex Keratitis With Oral Valganciclovir in Patients Unresponsive or Allergic to Conventional Antiviral Therapy.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA.

Purpose: To describe 4 cases of presumably immunocompetent patients with herpes simplex virus (HSV) keratitis unresponsive (n = 3) or allergic (n = 1) to conventional antiviral therapy that improved with oral valganciclovir treatment.

Methods: Retrospective case series of 4 patients with HSV keratitis treated with oral valganciclovir between March 2016 and June 2018.

Results: We reviewed the records of 4 patients with recurrent epithelial HSV keratitis. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001917DOI Listing
March 2019
3 Reads

Corneal Cross-Linking: The Science Beyond the Myths and Misconceptions.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmacy, University Federico II of Naples, Naples, Italy.

Purpose: There has been a recent explosion in the variety of techniques used to accomplish corneal cross-linking (CXL) for the treatment of ectatic corneal diseases. To understand the success or failure of various techniques, we review the physicochemical basis of corneal CXL and re-evaluate the current principles and long-standing conventional wisdom in the light of recent, compelling, and sometimes contradictory research.

Methods: Two clinicians and a medicinal chemist developed a list of current key topics, controversies, and questions in the field of corneal CXL based on information from current literature, medical conferences, and discussions with international practitioners of CXL. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001912DOI Listing
March 2019
5 Reads

Outcomes of Cyanoacrylate Tissue Adhesive Application in Corneal Thinning and Perforation.

Cornea 2019 Mar 7. Epub 2019 Mar 7.

Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.

Purpose: To report the outcomes of cyanoacrylate tissue adhesive (CTA) application in corneal thinning and perforation.

Methods: A retrospective interventional case series of 137 patients receiving CTA for corneal thinning and perforation in 140 eyes between 2001 and 2018 at a single center was reviewed. Success rate and factors associated with glue failure were analyzed. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001919DOI Listing
March 2019
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Corneal Biofilm Plaques: A Novel Clinical Presentation.

Cornea 2019 Mar 7. Epub 2019 Mar 7.

Department of Cornea and Refractive Surgery, Institute of Ophthalmology "Conde de Valenciana," Mexico City, Mexico.

Purpose: To report a novel clinical presentation of corneal biofilms, consisting of formation of superficial and recurrent corneal plaques.

Methods: Interventional case report. A 9-year-old boy presented with subepithelial, whitish, avascular, and recurrent corneal plaques without any clinical manifestations of active corneal inflammation and/or infection. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001923DOI Listing

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Cornea 2019 May;38(5):e15-e16

Division of Cornea and Ocular Surface, Ohshima Eye Hospital, Fukuoka, Japan.

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http://dx.doi.org/10.1097/ICO.0000000000001903DOI Listing

Keratoconus Corneal Posterior Surface Characterization According to the Degree of Visual Limitation.

Cornea 2019 Mar 6. Epub 2019 Mar 6.

Cornea and Refractive Surgery Department, Vissum, Alicante, Spain.

Purpose: To characterize posterior corneal surface features in patients with keratoconus and healthy controls and correlate them with the severity of the disease according to visual limitation.

Methods: Retrospective, comparative, clinical study including 477 cases, 374 keratoconic eyes and 103 healthy corneas. Patients were classified according to the degree of visual limitation. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001909DOI Listing
March 2019
2 Reads

Identification of a Novel ZNF469 Mutation in a Pakistani Family With Brittle Cornea Syndrome.

Cornea 2019 Mar 6. Epub 2019 Mar 6.

Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The Netherlands.

Purpose: Brittle cornea syndrome (BCS) is a rare recessive disorder affecting connective tissues, most prominently in the eye. Pathogenic mutations causing BCS have been identified in PRDM5 and ZNF469 genes. This study investigates the genetic cause of BCS in a large, consanguineous Pakistani family with 4 affected and 3 unaffected individuals. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001828DOI Listing

Efficacy of Vectored Thermal Pulsation and Warm Compress Treatments in Meibomian Gland Dysfunction: A Meta-Analysis of Randomized Controlled Trials.

Cornea 2019 Mar 4. Epub 2019 Mar 4.

Center for Evidence-Based Health Care and Shared Decision Making Resource Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Purpose: Meibomian gland dysfunction is the main cause of dry eye disease (DED) and is traditionally managed using warm compress treatment (WCT). Vectored thermal pulsation treatment (VTPT) is a novel method for treating DED.

Methods: We conducted a systematic review and meta-analysis of randomized controlled trials that compared the efficacy of VTPT and WCT in treating DED. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001907DOI Listing

Phacoemulsification With 3.0 and 2.0 mm Opposite Clear Corneal Incisions for Correction of Corneal Astigmatism.

Cornea 2019 Mar 5. Epub 2019 Mar 5.

The Affiliated Eye Hospital of Wenzhou Medical University, Zhejiang, China.

Purpose: To compare the effect of 3.0 and 2.0 mm opposite clear corneal incisions (OCCIs) in phacoemulsification on reduction of preexisting corneal astigmatism, and their impact on corneal aberrations. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001915DOI Listing
March 2019
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Management of Descemet Membrane's Folds After Deep Anterior Lamellar Keratoplasty: Descemet Membrane-Tucking Technique.

Cornea 2019 Mar 5. Epub 2019 Mar 5.

Ophthalmology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Purpose: To describe a surgical maneuver that allows for correction of central Descemet membrane (DM) folds at the end of a deep anterior lamellar keratoplasty (DALK) procedure. We term the present technique "DM tucking."

Methods: A blunt tip spatula is introduced vertically into the trephination cut, 90 degrees away from the main direction of the DM folds, and advanced until it touches the host layer. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001910DOI Listing