6,786 results match your criteria Cornea[Journal]


Comparison of Tri-folded and Scroll-Based Graft Viability in Preloaded Descemet Membrane Endothelial Keratoplasty.

Cornea 2018 Dec 13. Epub 2018 Dec 13.

Wilmer Eye Institute at Johns Hopkins University School of Medicine, Baltimore, MD.

Purpose: To compare corneal endothelial damage associated with 2 techniques for preloaded Descemet membrane endothelial keratoplasty (DMEK): a tri-folded graft stored in a plastic cartridge designed for DMEK and a scrolled graft stored in a modified Jones Tube, at the time of preparation and after shipping.

Methods: DMEK grafts were prepared at the Rocky Mountain Lions Eye Bank. The grafts were either tri-folded and loaded in a plastic cartridge or scrolled and loaded into a modified Jones Tube. Read More

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December 2018

Femtosecond Laser-Assisted Deep Lamellar Descemet Membrane Endothelial Keratoplasty for the Treatment of Endothelial Dysfunction Associated With Posterior Stromal Scarring.

Cornea 2018 Dec 7. Epub 2018 Dec 7.

Cornea, Cataract and Refractive Surgery Unit, Vissum Corporación, Alicante, Spain.

Purpose: To describe an alternative surgical approach, femtosecond laser-assisted deep lamellar Descemet membrane endothelial keratoplasty (Femto-DL-DMEK), for the treatment of corneal endothelial diseases associated with posterior stromal scarring.

Methods: Case report of a 52-year-old man with pseudophakic bullous keratopathy and posterior corneal scarring secondary to viral endotheliitis who underwent Femto-DL-DMEK. The surgical technique was as follows: First, a manual lamellar dissection plane was created at approximately 75% to 85% depth through a 5. Read More

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December 2018

Vitamin D Enhances the Efficacy of Topical Artificial Tears in Patients With Dry Eye Disease.

Cornea 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Hallym University College of Medicine, Seoul, Korea.

Purpose: To investigate the efficacy of topical carbomer-based lipid-containing artificial tears (CLAT) and hyaluronate (HU) in patients with dry eye disease (DED) based on serum 25-hydroxyvitamin D (25HD) levels and cholecalciferol (vitamin D) supplementation.

Methods: A total of 116 patients with DED from June 2015 to June 2016 were included. The participants were divided into the vitamin D deficiency (VDD) group and the non-VDD group according to their serum 25HD levels. Read More

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December 2018
2 Reads

Topical Rho-Associated Kinase Inhibitor, Y27632, Accelerates Corneal Endothelial Regeneration in a Canine Cryoinjury Model.

Cornea 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA.

Purpose: Corneal endothelial cell regeneration varies by species, with nonhuman primates (NHPs) and rabbits displaying low and high proliferative capacities, respectively. Recent studies report that topical application of rho-associated kinase (ROCK) inhibitors accelerates corneal endothelial wound healing in animal models and human patients with endothelial dysfunction. This study determines the regenerative capacity of canine corneal endothelial cells in vivo and their response to a topical ROCK inhibitor, Y27632, after transcorneal freezing. Read More

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November 2018
1 Read

Conjunctival Colloid Milium.

Cornea 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: To describe a rare case of conjunctival colloid milium.

Methods: Case report.

Results: We report a 45-year-old woman with a history of a slow-growing, painless mass extending from the medial canthal region to the inferior fornix and the inferior bulbar conjunctiva associated with redness. Read More

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November 2018
1 Read

Combined Keratectomy and Localized Limbal Cauterization for Treating Lisch Epithelial Corneal Dystrophy.

Cornea 2018 Nov 27. Epub 2018 Nov 27.

Department of Ophthalmology, Centro de Oftalmología Barraquer, Universitat Internacional de Catalunya, Barcelona, Spain.

Purpose: To present a new technique for treating Lisch epithelial corneal dystrophy (LECD) in cases of recurrence of the disease.

Methods: We present a single case report of a 41-year-old man who presented to the cornea clinic with progressive loss of vision in the right eye. Slit-lamp examination showed a large white-gray whorl-like epithelial opacity connected to the limbus, which spread over the visual axis, affecting visual acuity. Read More

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November 2018
3 Reads

Management of Type 2 Bubble Formed During Big Bubble Deep Anterior Lamellar Keratoplasty.

Cornea 2018 Nov 27. Epub 2018 Nov 27.

Sussex Eye Hospital, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom.

Purpose: To review the outcome of 3 techniques for managing type 2 bubbles (between Descemet's membrane [DM] and stroma) formed during big bubble (BB) deep anterior lamellar keratoplasty (DALK) in different corneal pathologies.

Methods: This is an interventional case series study of patients with type 2 bubbles formed during BB DALK. Three techniques to complete DALK are described: the first is a DM baring technique similar to Anwar's BB technique, the second is the microbubble incision technique to preserve the pre-Descemetic support to DM, and the third is done in eyes with combined type 1 and type 2 BB (mixed bubble), where the type 1 bubble is opened and surgery is completed avoiding the type 2 bubble. Read More

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November 2018
4 Reads
2.360 Impact Factor

Association of Iris Damage With Reduction in Corneal Endothelial Cell Density After Penetrating Keratoplasty.

Cornea 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.

Purpose: To evaluate the effect of iris damage on endothelial cell loss in the early phase after penetrating keratoplasty (PKP).

Methods: This prospective consecutive study included 74 patients who underwent PKP without graft rejection during the follow-up period. Endothelial cell density (ECD) was measured using specular microscopy at 1, 3, 6, and 12 months after PKP. Read More

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November 2018

Reply.

Cornea 2018 Nov 13. Epub 2018 Nov 13.

Department of Ophthalmology and Visual Sciences, The University of British Columbia, Vancouver, Canada.

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November 2018
2 Reads

Anterior Segment Complications Associated With the Live Herpes Zoster Vaccine.

Authors:
Dong Hyun Kim

Cornea 2018 Nov 13. Epub 2018 Nov 13.

Department of Ophthalmology, Gachon University College of Medicine, Gil Medical Center, Incheon, Korea.

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November 2018
2 Reads

Repeatability of Meibomian Gland Contrast, a Potential Indicator of Meibomian Gland Function.

Cornea 2018 Nov 13. Epub 2018 Nov 13.

Clinical Research Center, School of Optometry, University of California, Berkeley, Berkeley, California.

Purpose: Meibomian gland contrast may be a potential indicator of gland health, especially among isotretinoin users. We aimed to develop a repeatable and reliable method for measuring Meibomian gland contrast from meibography images.

Methods: Lower lid (LL) and upper lid (UL) meibography were captured with the OCULUS Keratograph 5M (OCULUS, Inc) at 2 visits under the following 4 conditions: face centered with room lights on (C), left-turned face (L), right-turned face (R), and face centered with room lights off (CLO). Read More

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November 2018
7 Reads

Evaluation of Big Bubble Technique for Deep Anterior Lamellar Keratoplasty in Patients With Radial Keratotomy.

Cornea 2018 Nov 13. Epub 2018 Nov 13.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.

Purpose: To report the outcome of deep anterior lamellar keratoplasty (DALK) and success rates of the big-bubble (BB) technique or manual dissection after a failed use of the BB technique in eyes that underwent prior radial keratotomy (RK).

Methods: A retrospective chart review of patients who underwent DALK after RK at Toronto Western Hospital, Canada, between 1999 and 2017 was performed. Demographic characteristics, success rates of the BB technique and manual dissection, intraoperative and postoperative complications, and best spectacle-corrected visual acuity before and after corneal transplant were analyzed. Read More

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November 2018
7 Reads

Reply.

Cornea 2018 Nov 12. Epub 2018 Nov 12.

Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, MI.

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November 2018

Efficacy of Luliconazole Against Broad-Range Filamentous Fungi Including Fusarium solani Species Complex Causing Fungal Keratitis.

Cornea 2018 Nov 12. Epub 2018 Nov 12.

Department of Ophthalmology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Purpose: Fungal keratitis can be difficult to medically treat. Topical antifungals are usually applied empirically as the initial option in treating fungal keratitis. Natamycin (NAT) and/or voriconazole (VRCZ) have been widely used in the treatment of fungal keratitis. Read More

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November 2018
3 Reads

Microbiological Evaluation of Bandage Soft Contact Lenses Used in Management of Persistent Corneal Epithelial Defects.

Cornea 2018 Nov 12. Epub 2018 Nov 12.

Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To investigate the rate and agents of contamination in bandage soft contact lenses fitted for management of persistent corneal epithelial defects.

Methods: This prospective comparative case series enrolled 57 consecutive eyes fitted with bandage contact lenses for treatment of persistent corneal epithelial defects. The lenses were collected at the time of epithelial closure or when it was necessary to exchange contact lenses and were immediately placed in sterile tubes containing an enriched thioglycolate liquid medium. Read More

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November 2018
4 Reads

"Ghost DMEK" Technique: Circular Peripheral Staining of Descemet's Membrane Endothelial Keratoplasty Grafts.

Cornea 2018 Nov 12. Epub 2018 Nov 12.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To describe the ghost Descemet's membrane endothelial keratoplasty (DMEK) technique that allows for real-time evaluation of DMEK graft orientation, location, and folding status within the anterior chamber, by simple observation at the surgical microscope.

Methods: This is a retrospective case series done in a university hospital. The study included 10 patients who underwent ghost DMEK surgery because of corneal endothelial insufficiency for Fuchs' endothelial dystrophy (N = 5), pseudophakic bullous keratopathy (N = 2), and failed previous posterior lamellar keratoplasty (N = 3). Read More

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November 2018
4 Reads

Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction.

Cornea 2018 Nov 8. Epub 2018 Nov 8.

Division of Cornea and Ocular Surface, Ohshima Eye Hospital, Fukuoka, Japan.

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November 2018
4 Reads

Bilateral Ulcerative Keratitis Associated With Afatinib Treatment for Non-Small-Cell Lung Carcinoma.

Cornea 2018 Nov 8. Epub 2018 Nov 8.

Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, NHS Trust, East Grinstead, West Sussex, United Kingdom.

Purpose: To report a case of afatinib-related bilateral ulcerative keratitis.

Methods: An 85-year-old female patient on treatment with afatinib for non-small-cell lung carcinoma presented with progressive redness, pain, and decreased vision in both eyes. Four weeks before the onset of symptoms, afatinib therapy had been commenced at a dose of 40 mg, once daily. Read More

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November 2018
3 Reads

Minimizing Endothelial Cell Loss Caused by Orientation Stamps on Preloaded Descemet Membrane Endothelial Keratoplasty Grafts.

Cornea 2018 Nov 8. Epub 2018 Nov 8.

Lions VisionGift, Portland, OR.

Purpose: To quantify endothelial cell loss (ECL) caused by orientation stamps on prestripped and preloaded Descemet membrane endothelial keratoplasty (DMEK) grafts, and to examine a method for reducing ECL using a smaller stamp.

Methods: Ten prestripped and 10 preloaded DMEK grafts were prepared with S-stamps. Ten additional preloaded DMEK grafts were prepared with both an S-stamp and a smaller F-stamp in different paracentral areas of the graft. Read More

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November 2018
4 Reads

Cross-Country Transportation Efficacy and Clinical Outcomes of Preloaded Large-Diameter Ultra-Thin Descemet Stripping Automated Endothelial Keratoplasty Grafts.

Cornea 2019 Jan;38(1):30-34

Department of Ophthalmology, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom.

Purpose: To evaluate the clinical outcomes of preloaded large-diameter ultra-thin grafts for Descemet stripping automated endothelial keratoplasty (UT-DSAEK) after cross-country shipment.

Methods: A laboratory study in an eye bank and a clinical cohort study in an academic tertiary care center were performed. UT-DSAEK (9. Read More

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January 2019

Ocular and Genetic Characteristics Observed in Two Cases of Fish-Eye Disease.

Cornea 2018 Nov 2. Epub 2018 Nov 2.

Department of Ophthalmology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey.

Purpose: To present ocular findings and anterior segment-optical coherence tomography (AS-OCT) imaging findings of 2 cases of fish-eye disease (FED) involving 2 novel genetic variants of the lecithin-cholesterol acyltransferase (LCAT) gene.

Methods: A case report.

Results: A 46-year-old woman and 63-year-old man presented with blurred vision, burning sensation, and whitening of both eyes for 2 and 3 years, respectively. Read More

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November 2018
5 Reads

Ocular Toxicity of Mirvetuximab.

Cornea 2018 Oct 30. Epub 2018 Oct 30.

Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy.

Purpose: To report the clinical features and outcomes of corneal toxicity following mirvetuximab soravtansine therapy.

Methods: Five patients who were treated with mirvetuximab soravtansine were evaluated in our hospital for ocular symptoms during a period of 5 months between December 2017 and April 2018. A complete ophthalmologic examination, including anterior segment infrared reflectance (AS-IR) and anterior segment optical coherence tomography (AS-OCT), was performed. Read More

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October 2018
1 Read

Tear Meniscus and Corneal Sub-basal Nerve Plexus Assessment in Primary Sjögren Syndrome and Sicca Syndrome Patients.

Cornea 2018 Oct 30. Epub 2018 Oct 30.

Department of Ophthalmology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Purpose: To evaluate lower tear meniscus and corneal sub-basal nerve plexus in primary Sjögren's syndrome (pSS) and Sicca syndrome patients.

Methods: Cross-sectional study of 116 patients with Sicca syndrome associated with pSS and not associated with Sjögren's syndrome (non-SS Sicca) and 20 normal control subjects. Tear meniscus height and area were measured using anterior segment optical coherence tomography; corneal sub-basal nerve plexus density, length, and tortuosity were evaluated using in vivo confocal microscopy. Read More

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October 2018
3 Reads

Response to "Central Corneal Thickness Evaluation in Diabetic Peripheral Neuropathy".

Cornea 2018 Oct 30. Epub 2018 Oct 30.

Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy.

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October 2018
2 Reads

Evaluation of the Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping for a 9-mm Zone Using Optical Coherence Tomography.

Cornea 2019 Jan;38(1):67-73

Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX.

Purpose: To evaluate the repeatability and between-machine/operator reproducibility of optical coherence tomography (RTVue-XR) for mapping corneal epithelial thickness (ET) and corneal thickness (CT) over a 9-mm zone.

Methods: In 5 groups of eyes (normal, contact lens, dry eye, post-LASIK/PRK, and keratoconus), corneal ET and CT were evaluated in 25 areas in the following 4 regions: 1) 1 central zone within 0 to 2.0 mm diameter, 2) 8 paracentral zones from 2. Read More

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January 2019
12 Reads
2.360 Impact Factor

Topical Ganciclovir for Prophylaxis of Cytomegalovirus Endotheliitis in Endothelial Keratoplasty.

Cornea 2019 Jan;38(1):120-122

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Purpose: To describe the presentation and management of 2 cases of Descemet stripping automated endothelial keratoplasty (DSAEK) with failure secondary to cytomegalovirus (CMV) infection and prophylaxis with topical ganciclovir to prevent repeat failure of Descemet membrane endothelial keratoplasty (DMEK) regrafts.

Methods: A retrospective chart review was conducted for 2 patients with DSAEK failure secondary to CMV infection.

Results: A 70-year-old immunocompetent man (case 1) and a 53-year-old immunocompromised man (case 2) received DSAEK for presumed pseudophakic bullous keratopathy and endothelial decompensation secondary to recurrent uveitis, respectively. Read More

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January 2019
3 Reads

Classification of Limbal Stem Cell Deficiency Using Clinical and Confocal Grading.

Cornea 2019 Jan;38(1):1-7

Cornea Division, Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA.

Purpose: To grade the severity of limbal stem cell deficiency (LSCD) based on the extent of clinical presentation and central corneal basal epithelial cell density (BCD).

Methods: This is a retrospective observational comparative study of 48 eyes of 35 patients with LSCD and 9 eyes of 7 normal subjects (controls). Confocal images of the central cornea were acquired. Read More

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January 2019
12 Reads

Evaluation of Autologous Blood in Pterygium Surgery With Conjunctival Autograft.

Cornea 2018 Oct 23. Epub 2018 Oct 23.

Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Purpose: Autologous blood has been used exploratively with conjunctival autograft in pterygium surgery. However, it is controversial whether autologous blood performed better than other fixation methods, including fibrin glue and sutures. This meta-analysis was conducted to evaluate the effectiveness of using autologous blood in pterygium surgery with conjunctival autograft. Read More

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October 2018
9 Reads

Ocular Surface Stem Cell Transplantation for Treatment of Keratitis-Ichthyosis-Deafness Syndrome.

Cornea 2019 Jan;38(1):123-126

Department of Ophthalmology, Cincinnati Eye Institute, University of Cincinnati, Cincinnati, OH.

Purpose: To report our surgical experience with ocular surface stem cell transplantation (OSST) for limbal stem cell deficiency (LSCD) in the setting of keratitis-ichthyosis-deafness (KID) syndrome.

Methods: Retrospective interventional case series.

Results: We present 5 eyes of 3 patients with KID syndrome that developed LSCD and underwent OSST. Read More

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January 2019
10 Reads

Vault Changes Caused by Light-Induced Pupil Constriction and Accommodation in Eyes With an Implantable Collamer Lens.

Cornea 2018 Oct 26. Epub 2018 Oct 26.

Department of Eye Center, Sanno Hospital, Tokyo, Japan.

Purpose: An appropriate vault after implantation of a posterior chamber phakic intraocular lens with a central hole (ICL KS-AP) is important for successful long-term outcomes. In the present study, we used anterior segment optical coherence tomography (AS-OCT) to examine dynamic pupil and vault changes under photopic and scotopic conditions and during accommodation in eyes with ICL KS-AP.

Methods: This retrospective study included patients at an outpatient ophthalmology clinic who underwent ICL KS-AP implantation >1 month before enrollment. Read More

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October 2018
5 Reads

Randomized Study of Collagen Cross-Linking With Conventional Versus Accelerated UVA Irradiation Using Riboflavin With Hydroxypropyl Methylcellulose: Two-Year Results.

Cornea 2018 Oct 24. Epub 2018 Oct 24.

Department of Ophthalmology, Oslo University Hospital, Norway.

Purpose: To compare the clinical outcome 2 years after corneal collagen cross-linking (CXL) with conventional and accelerated ultraviolet A (UVA) irradiation using riboflavin with hydroxypropyl methylcellulose.

Methods: Prospective randomized controlled study. Forty patients with keratoconus (40 eyes) were randomized to either CXL using conventional 3 mW/cm UVA irradiation for 30 minutes (CXL30 group) or accelerated 9 mW/cm UVA irradiation for 10 minutes (CXL10 group). Read More

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October 2018
4 Reads

High-Dose Steroid Treatment of Bacterial Keratitis.

Cornea 2018 Oct 24. Epub 2018 Oct 24.

School of Optometry and Vision Science, University of New South Wales, Australia.

Purpose: To describe the usage patterns of steroids in bacterial keratitis and to analyze the effect of steroids on patients' visual outcomes.

Methods: This was a single-center retrospective review of patients with culture-positive bacterial keratitis treated between 1999 and 2015 at Princess Alexandra Hospital (Brisbane, Australia). Patients with culture-positive bacterial keratitis were identified through the Queensland Pathology Database, and clinical information was gathered through a subsequent medical record review. Read More

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October 2018
3 Reads

Preloaded Descemet Membrane Endothelial Keratoplasty Donor Tissue: Surgical Technique and Early Clinical Results.

Cornea 2019 Jan;38(1):e1

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

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January 2019

Retrospective Single-Center Registry Study on Graft Thickness 1 Year After Descemet Stripping Automated Endothelial Keratoplasty.

Cornea 2018 Oct 19. Epub 2018 Oct 19.

Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark.

Purpose: To compare the graft thickness of eye bank precut grafts with graft thickness measured 1 year after Descemet stripping automated endothelial keratoplasty (DSAEK) and to correlate the graft thickness of eye bank precut grafts with best spectacle-corrected visual acuity (BSCVA) and endothelial cell density (ECD) 1 year after DSAEK.

Methods: This was a retrospective registry study of 183 eyes of 179 DSAEK patients. Grafts were cut in the eye bank after 1 day in dextran-containing medium, and thickness was measured by optical coherence tomography immediately after precutting. Read More

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October 2018
4 Reads

Influence of Intraoperative Air Tamponade Time on Graft Adherence in Descemet Membrane Endothelial Keratoplasty.

Cornea 2018 Oct 19. Epub 2018 Oct 19.

Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.

Purpose: To study the influence of different intraoperative air tamponade times on graft adherence after Descemet membrane endothelial keratoplasty (DMEK).

Methods: In this interventional case series, we evaluated 117 eyes with Fuchs endothelial corneal dystrophy (FECD) that underwent DMEK using intraoperative air tamponade times of 60 minutes (group I; n = 39), 45 minutes (group II; n = 39), or 30 minutes (group III; n = 39). At 1 and 6 months postoperatively, graft adherence status, endothelial cell density, central pachymetry, and postoperative complications were recorded. Read More

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October 2018
6 Reads

Postoperative Repositioning of Inverted Descemet Membrane Endothelial Keratoplasty Grafts.

Cornea 2018 Oct 19. Epub 2018 Oct 19.

Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.

Purpose: To present 4 cases of postoperative repositioning of inverted grafts after Descemet membrane endothelial keratoplasty (DMEK).

Methods: Retrospective case reports of 4 patients presenting with subtotal to total graft detachment after DMEK, most probably owing to upside-down graft positioning. Graft repositioning was performed 1 to 14 days after initial DMEK surgery. Read More

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October 2018

Capnocytophaga Keratitis: Clinical Presentation and Use of Metagenomic Deep Sequencing for Diagnosis.

Cornea 2018 Oct 19. Epub 2018 Oct 19.

Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA.

Purpose: To report our experience with 2 cases of Capnocytophaga keratitis.

Methods: This is a retrospective study of case reports. We present the clinical presentation, diagnosis, and treatment strategies of 2 patients who presented with Capnocytophaga keratitis. Read More

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October 2018
1 Read

Use of a Purpose-Built Impression Cytology Device for Gene Expression Quantification at the Ocular Surface Using Quantitative PCR and Droplet Digital PCR.

Cornea 2019 Jan;38(1):127-133

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand.

Purpose: To describe an impression cytology (IC) technique using a purpose-built, sterile, EYEPRIM IC device that can be coupled with a TRIzol reagent-based RNA extraction protocol to yield sufficient RNA for gene expression analysis.

Methods: IC samples using the EYEPRIM device were collected from the bulbar conjunctiva, with and without topical anesthesia, and evaluated for RNA yield, the absence of polymerase chain reaction (PCR) inhibitors, and the ability to detect biomarkers by quantitative real-time PCR and droplet digital PCR. A technique for collecting IC samples in the clinic, while preserving RNA, and a protocol for subsequent laboratory analysis of RNA were developed. Read More

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January 2019
8 Reads

Reply.

Cornea 2019 Jan;38(1):e1-e2

Cornea Service, Devers Eye Institute, Portland, OR.

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January 2019

Descemet Membrane Endothelial Keratoplasty (DMEK) Graft Dislocation Into the Vitreous Cavity.

Cornea 2018 Oct 16. Epub 2018 Oct 16.

Vitreo-Retinal Service, Moorfields Eye Hospital, London, United Kingdom.

Purpose: To present our experience of Descemet stripping endothelial keratoplasty (DMEK) graft luxation into the vitreous cavity in 2 cases.

Methods: DMEK was performed in 2 patients with aphakic bullous keratopathy. The indications for keratoplasty were endothelial failure caused by chronic intermediate uveitis and glaucoma in 1 case and decompensated previous penetrating keratoplasty in the other. Read More

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October 2018
2 Reads

Secukinumab-Associated Crystalline Corneal Deposition.

Cornea 2018 Oct 16. Epub 2018 Oct 16.

Ophthalmology Department, Mater Misericordiae University Hospital, Dublin, Republic of Ireland.

Purpose: To describe the first reported case of corneal crystalline deposition associated with the monoclonal antibody secukinumab (Cosentyx; Novartis, Basel, Switzerland) and the subsequent follow-up of the case.

Methods: Case report.

Results: An 18-year-old man was referred for a corneal opinion 1 year after commencing secukinumab monoclonal antibody therapy for ankylosing spondylitis. Read More

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October 2018
5 Reads

Management Algorithm for Fungal Keratitis: The TST (Topical, Systemic, and Targeted Therapy) Protocol.

Cornea 2018 Oct 16. Epub 2018 Oct 16.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To evaluate the efficacy of the topical, systemic and targeted therapy (TST) protocol in management of fungal keratitis.

Method: All cases of treatment-naive smear- or culture-proven fungal keratitis presenting between June 2013 and May 2017 were recruited. The TST protocol included initial treatment with topical natamycin 5% with addition of oral ketoconazole or voriconazole in ulcers with size >5 mm, depth >50%, or impending perforation. Read More

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October 2018
4 Reads
2.360 Impact Factor

Using Deep Learning in Automated Detection of Graft Detachment in Descemet Membrane Endothelial Keratoplasty: A Pilot Study.

Cornea 2018 Oct 5. Epub 2018 Oct 5.

Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.

Purpose: To evaluate a deep learning-based method to automatically detect graft detachment (GD) after Descemet membrane endothelial keratoplasty (DMEK) in anterior segment optical coherence tomography (AS-OCT).

Methods: In this study, a total of 1172 AS-OCT images (609: attached graft; 563: detached graft) were used to train and test a deep convolutional neural network to automatically detect GD after DMEK surgery in AS-OCT images. GD was defined as a not completely attached graft. Read More

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October 2018
1 Read

Stenciling-Based "Prick and Print" Technique for Harvesting Shaped Corneal Grafts for Management of Peripheral Corneal Perforations.

Cornea 2019 Jan;38(1):105-109

Department of Cornea and Refractive Services, Sadguru Seva Sang Trust, Chitrakoot, Madhya Pradesh, India.

Purpose: To evaluate a new surgical technique ("prick and print") for harvesting shaped donor corneal grafts in cases with perforated peripheral ulcerative keratitis (PUK).

Methods: We conducted a retrospective case series at a tertiary center. Medical records of 13 patients with perforated PUK, who underwent tectonic eccentric keratoplasty using the stenciling-based prick and print technique during the past 1 year, were reviewed. Read More

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January 2019
1 Read

Concurrent Microbial Keratitis and Nasolacrimal Duct Obstruction: Concordance, Etiopathogenesis, and Outcome.

Cornea 2019 Jan;38(1):84-88

Ophthalmic Plastic and Reconstructive Surgery Service, L. V. Prasad Eye Institute, Bhubaneswar, Odisha, India.

Purpose: Nasolacrimal duct obstruction (NLDO) is believed to be a risk factor for microbial keratitis (MK). The primary objective of this study was to look at microbiological concordance between corneal scraping and lacrimal sac flora in patients with concurrent MK and NLDO. The secondary objective was to compare microbiological isolates from MK and NLDO, MK alone, NLDO alone, and healthy subjects. Read More

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January 2019
1 Read

Precut DMEK Using Dextran-Containing Storage Medium Is Equivalent to Conventional DMEK: A Prospective Pilot Study.

Cornea 2019 Jan;38(1):24-29

Department of Ophthalmology, Eye Clinic Sulzbach, Knappschaft Hospital Saar, Sulzbach/Saar, Germany.

Purpose: To compare the clinical outcome after Descemet membrane endothelial keratoplasty (DMEK) either as precut or conventional Descemet membrane graft preparation under standard European eye bank organ culture conditions.

Methods: This was a prospective pilot study of patients receiving either precut or conventional DMEK. Graft preparation was performed using the liquid bubble technique. Read More

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January 2019
2 Reads

Two Femtosecond Laser LASIK Platforms: Comparison of Evolution of Visual Acuity, Flap Thickness, and Stromal Optical Density.

Cornea 2019 Jan;38(1):98-104

Clinica Novovisión, Madrid, Spain.

Purpose: To compare postoperative evolution of visual acuity, flap thickness, and stromal optical density during the first 3 months after femtosecond (FS) laser in situ keratomileusis surgery for correction of myopia using the iFS 150-kHz FS laser and LenSx FS laser platforms.

Methods: This was a prospective case series. Thirty-nine eyes treated with the iFS 150-kHz FS laser versus 38 refraction-matched eyes treated with the LenSx FS laser platform were included. Read More

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January 2019
5 Reads

Long-Term Results of Femtosecond Laser-Enabled Keratoplasty With Zig-Zag Trephination.

Cornea 2019 Jan;38(1):42-49

Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, Irvine, CA.

Purpose: To report long-term visual and astigmatism outcomes in cases of zig-zag femtosecond laser-enabled penetrating keratoplasty (FLEK).

Methods: Retrospective review. Three hundred thirty-five eyes of 287 patients underwent (FLEK) with a zig-zag incision pattern. Read More

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January 2019
1 Read

Descemet's Membrane Biomimetic Microtopography Differentiates Human Mesenchymal Stem Cells Into Corneal Endothelial-Like Cells.

Cornea 2019 Jan;38(1):110-119

Medical Center for Ophthalmology, Chemnitz, Germany.

Purpose: Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. Corneal transplantation is currently the only therapy for severe corneal disorders. However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. Read More

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January 2019
2 Reads

Influence of Incision Size on Dry Eye Symptoms in the Small Incision Lenticule Extraction Procedure.

Cornea 2019 Jan;38(1):18-23

Konyagoz Eye Hospital, Konya Turkey.

Purpose: To evaluate the influence of incision size on dry eye symptoms in the small incision lenticule extraction (SMILE) procedure.

Methods: Ninety-four eyes of 47 patients with myopia and/or myopic astigmatism who had undergone the SMILE procedure were enrolled in this study. The patients were divided into 3 groups according to the incision size (2, 3, and 4 mm) applied during the SMILE procedure. Read More

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January 2019
2 Reads