290,029 results match your criteria Core Evidence[Journal]


Cluster Headache and Other Trigeminal Autonomic Cephalalgias.

Authors:
Brian E McGeeney

Semin Neurol 2018 Dec 6;38(6):603-607. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

The trigeminal autonomic cephalalgias are a group of distinct primary headache disorders that share common characteristics of strict unilateral headache often accompanied by unilateral cranial autonomic features. Cluster headache is the most well-known example, but other than neurologists, practitioners often have limited familiarity with these disorders and treatment options. Delays in diagnosis are typical and treatment options remain suboptimal, associated with limited scientific research into these brain disorders. Read More

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December 2018
1 Read

Early impact of pulmonary stereotactic fractionated body radiotherapy (SBRT) on Quality of Life (QoL): Benefit for patients with low initial scores (STRIPE trial).

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

Introduction: Quality of life (QoL) of comorbid patients with pulmonary malignancies is a key issue in considering stereotactic fractionated body radiotherapy (SBRT) indication. This study investigates the early impact of SBRT on QoL.

Methods: 100 patients with pulmonary lesions were treated with SBRT from 02/2011 to 11/2014 within the prospective, monocenter, phase II STRIPE trial. Read More

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December 2018
1 Read

Design, synthesis and anti-tumor evaluation of novel steroidal glycoconjugate with furoxan derivatives.

Steroids 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address:

In this study, eighteen novel steroidal-furoxan derivatives with 3-glycosyl or 3-methoxy moiety (12a-c, 13a-c, 17a-c, 26a-c, 27a-c and 28a-c) were synthesized and their anti-proliferative activity was evaluated against eight drug-sensitive and three drug-resistant cancer cell lines HeLa, A2780, LNCaP, PC-3, MDA-MB-231, MCF-7, SW480, A549, MCF-7/ADR, A2780/CDDP and A2780/T. Most of them displayed significant anti-cancer potency in vitro with IC values at the nanomole level. Among them, 3-methoxy steroidal-furoxan hybrids expressed much better activity than that of 3-glycosyl substitute ones, while estrane and 5α-H-androstane scaffold were slightly more favorable to the improvement of anti-proliferative activity. Read More

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December 2018
2 Reads

Ligand density and linker length are critical factors for multivalent nanoparticle-receptor interactions.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Although there is a large number of studies available evaluating the therapeutic efficacy of targeted polymeric nanoparticles, little is known about the critical attributes that can further influence their uptake into target cells. In this study, varying cRGD ligand densities (0-100% surface functionalization) were combined with different PEG spacer lengths (2/3.5/5kDa) and the specific receptor binding of targeted core-shell structured PLGA/PLA-PEG nanoparticles was evaluated using αβ integrin overexpressing U87MG glioblastoma cells. Read More

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December 2018
1 Read

[Infrapectineal plate for repair with minimal invasion of quadrilateral blade acetabular fractures: description new implant and paramedial access].

Acta Ortop Mex 2018 May-Jun;32(3):118-125

Instituto de Astronomía de la Universidad Nacional Autónoma de México.

Introduction: Quadrilateral plate fractures are the most difficult to reduce and fix. Different techniques have been developed for quadrilateral plate osteosynthesis. The objective of this work was to create an implant and a novel approach to simplify and improve acetabular fracture osteosynthesis. Read More

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December 2018

An improved power loss model of full-bridge converter under light load condition.

PLoS One 2018 6;13(12):e0208239. Epub 2018 Dec 6.

School of Electrical and Information Engineering, Tianjin University, Tianjin, China.

When the full-bridge converter works under the light load condition, the power efficiency obtained by the theoretical model is much different from that of the actual converter. Facing with this situation, an improved power loss model based on the typical power loss model is proposed. In this paper, the typical power loss model is called typical model for short and the improved power loss model is called proposed model for short. Read More

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December 2018
2 Reads

Diet and prevention of type 2 diabetes mellitus: beyond weight loss and exercise.

Expert Rev Endocrinol Metab 2018 Nov 29:1-12. Epub 2018 Nov 29.

a Midwest Biomedical Research/Center for Metabolic and Cardiovascular Health , Glen Ellyn , IL , USA.

Introduction: Insulin resistance (IR) and pancreatic beta-cell dysfunction are core pathophysiologic features of type 2 diabetes mellitus (T2DM). Select lifestyle and pharmacologic interventions, including weight loss, physical activity, a Mediterranean diet intervention, and hypoglycemic agents, have been shown to prevent or delay T2DM. However, dietary factors other than weight loss may also impact risk, mainly through effects to enhance insulin sensitivity, although some may also directly or indirectly impact pancreatic beta-cell function. Read More

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November 2018
1 Read

MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions.

FASEB J 2018 Dec 6:fj201801127R. Epub 2018 Dec 6.

Institute of Molecular Medicine and Cell Research, Medical Faculty, University of Freiburg, Freiburg, Germany.

Tumor-initiating cells (TICs) existing in breast cancer are thought to be involved in initiation, progression, and relapse of tumors. In these processes, the epithelial-to-mesenchymal transition (EMT) and proteases are crucial factors that also dependent on the tumor milieu, including hypoxic nutrient-deprived, as well as normoxic nutrient-rich, environments. Therefore, we investigated EMT and proteases in TICs and their response to different environments by means of a newly generated immortalized TIC (iTIC) line. Read More

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December 2018
1 Read

Pressure ulcer definitions and core curricula-how does this affect wound care and the older patient?

Br J Community Nurs 2018 Dec;23(Sup12):S6-S12

Professor and Director for the Institute of Skin Integrity and Infection prevention, Department of Nursing and Midwifery, University of Huddersfield, Queensgate, Huddersfield, West Yorkshire.

Chronic wounds are associated with a significant patient, healthcare and financial burden and can have extensive implications for healthcare. Age is a significant risk factor for developing chronic wounds, due to physical changes in skin integrity and several age-related complex comorbidities, including poor nutrition and mobility. Pressure ulcers (PU) are a common type of chronic wound that can have a substantial impact on health-related quality of life and patient outcomes. Read More

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December 2018
3 Reads

Understanding the Nanoscale Structure of Inverted Hexagonal Phase Lyotropic Liquid Crystal Polymer Membranes.

J Phys Chem B 2018 Dec 6. Epub 2018 Dec 6.

Periodic, nanostructured porous polymer membranes made from the cross-linked inverted hexagonal phase of self-assembled lyotropic liquid crystals (LLCs) are a promising class of materials for selective separations. In this work, we investigate an experimentally characterized LLC polymer membrane using atomistic molecular modeling. In particular, we compare simulated X-ray diffraction (XRD) patterns with experimental XRD data to quantify and understand the differences between simulation and experiment. Read More

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December 2018

Aromatic Nitrogen Mustard-Based Autofluorescent Amphiphilic Brush Copolymer as pH-Responsive Drug Delivery Vehicle.

Biomacromolecules 2018 Dec 6. Epub 2018 Dec 6.

Delivery of clinically approved nonfluorescent drugs is facing challenges because it is difficult to monitor the intracellular drug delivery without incorporating any integrated fluorescence moiety into the drug carrier. The present investigation reports the synthesis of a pH-responsive autofluorescent polymeric nano-scaffold for the administration of nonfluorescent aromatic nitrogen mustard chlorambucil (CBL) drug into the cancer cells. Copolymerization of poly(ethylene glycol) (PEG) appended styrene and CBL conjugated N-substituted maleimide monomers enables the formation of well-defined luminescent alternating copolymer. Read More

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December 2018
1 Read

Appearance of di- and Tripeptides in Human Plasma after a Protein Meal does not Correlate with PEPT1 Substrate Selectivity.

Mol Nutr Food Res 2018 Dec 6:e1801094. Epub 2018 Dec 6.

F. Rohm, Dr. H. Daniel, Dr. B. Spanier, Nutritional Physiology, Technical University of Munich, Freising, Germany.

Scope: PEPT1 function is well understood, yet little is known about its contribution towards the absorption of dietary amino acids in the form of di- and tripeptides. In the present human study, we investigated changes in plasma concentrations of a representative oligopeptide panel after meat intake.

Methods And Results: Based on an LC-MS/MS method for quantitative analysis of a panel of selected di- and tripeptides in biological samples, we describe the kinetics of plasma changes of peptides derived from a widely accessible dietary protein source. Read More

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December 2018

The Development of a Core Syllabus for Teaching Musculoskeletal Anatomy of the Vertebral Column and Limbs to Medical Students.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Introduction: The study of human anatomy is fundamental to medical education globally. Knowledge of musculoskeletal anatomy is essential for safe and effective clinical practice, yet this topic often receives insufficient medical programme time and perceptions differ regarding which knowledge is core. Given the lack of syllabuses specific to musculoskeletal anatomy, this paper aims to provide a detailed syllabus for the vertebral column and limbs relevant to medical students. Read More

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December 2018

Tolerance and efficacy of BRAF plus MEK inhibition in patients with melanoma who previously have received programmed cell death protein 1-based therapy.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Combined BRAF and MEK inhibition (BRAF-MEK) is a standard therapy for patients with BRAF V600-mutant melanoma, but to the authors' knowledge, the tolerance, adverse event (AE) profile, and efficacy have not been well defined in the post-programmed cell death protein 1 (PD-1) setting.

Methods: Patients with BRAF V600-mutant melanoma who received combined BRAF-MEK after prior PD-1-based therapy were assembled from 4 tertiary care centers in the United States and Australia. Dose modification was defined as a treatment break, dose reduction, or intermittent dosing. Read More

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December 2018

Introduction of D-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-L-Methionine Radical Epimerase.

Angew Chem Int Ed Engl 2018 Dec 6. Epub 2018 Dec 6.

ETH Zürich, Department of Biology, Vladimir-Prelog-Weg 4, 8093, Zürich, SWITZERLAND.

Post-translational modifying enzymes from the S-adenosyl-L-methionine (AdoMet) radical superfamily garner attention due to their ability to accomplish challenging biochemical reactions. Among them, a family of AdoMet radical epimerases catalyze irreversible L- to D-amino acid transformations of diverse residues, including 18 sites in the complex sponge-derived polytheonamide toxins. These enzymes are from the proteusin family of ribosomally synthesized and post-translationally modified peptide natural products and act on precursor proteins with relatively large N-terminal leaders and highly variable core sequences. Read More

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December 2018
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Histones Predate the Split Between Bacteria and Archaea.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany.

Motivation: Histones form octameric complexes called nucleosomes, which organize the genomic DNA of eukaryotes into chromatin. Each nucleosome comprises two copies each of the histones H2A, H2B, H3, and H4, which share a common ancestry. Although histones were initially thought to be a eukaryotic innovation, the subsequent identification of archaeal homologs led to the notion that histones emerged before the divergence of archaea and eukaryotes. Read More

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December 2018
3 Reads

Eye and Vision Health for Tomorrow: From Recommendations to Coordinated Action.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Indiana University School of Optometry, Bloomington.

In 2016, the report Making Eye Health a Population Health Imperative: Vision for Tomorrow was published by the National Academies of Sciences, Engineering, and Medicine. Conference presentations and key stakeholder discussions have continued the dialogue initiated by this report. In 2018, a stakeholder meeting assessed the feasibility of establishing a backbone organization, a national center that can provide technical and resource assistance regarding eye and vision health. Read More

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December 2018
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Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial.

Eur Heart J Cardiovasc Imaging 2018 Dec 5. Epub 2018 Dec 5.

Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, USA.

Aims: To update pretest probabilities (PTP) for obstructive coronary artery disease (CAD ≥ 50%) across age, sex, and clinical symptom strata, using coronary computed tomography angiography (CTA) in a large contemporary population of patients with stable chest pain referred to non-invasive testing.

Methods And Results: We included patients enrolled in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial and randomized to CTA. Exclusively level III-certified readers, blinded to demographic and clinical data, assessed the prevalence of CAD ≥ 50% in a central core lab. Read More

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December 2018

Correction: A synthetic study toward the core structure of (-)-apicularen A.

Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.

Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.

Correction for 'A synthetic study toward the core structure of (-)-apicularen A' by Tapas R. Pradhan et al., Org. Read More

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December 2018

Controlling the dominant magnetic relaxation mechanisms for magnetic hyperthermia in bimagnetic core-shell nanoparticles.

Nanoscale 2018 Dec 6. Epub 2018 Dec 6.

Instituto de Nanociencia y Nanotecnología, CNEA, CONICET, Centro Atómico Bariloche, Av. Bustillo 9500 (8400) S. C. Bariloche, Argentina.

We report a simple and effective way to control the heat generation of a magnetic colloid under alternate magnetic fields by changing the shell composition of bimagnetic core-shell Fe3O4/ZnxCo1-xFe2O4 nanoparticles. The core-shell structure constitutes a magnetically-coupled biphase system, with an effective anisotropy that can be tuned by the substitution of Co2+ by Zn2+ ions in the shell. Magnetic hyperthermia experiments of nanoparticles dispersed in hexane and butter oil showed that the magnetic relaxation is dominated by Brown relaxation mechanism in samples with higher anisotropy (i. Read More

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December 2018

Understanding the role of co-surfactants in microemulsions on the growth of copper oxalate using SAXS.

Phys Chem Chem Phys 2018 Dec 6. Epub 2018 Dec 6.

Institute of Nano-Science and Technology, Habitat Centre, Phase - 10, Sector - 64, Mohali-160062, India.

This study is an effort to understand the mechanism of the effect of the chain length of co-surfactants on the growth of copper oxalate inside the core of reverse micelles using small angle X-ray scattering (SAXS). In this study, we have used two different kinds of co-surfactants viz. 1-butanol (C4) and 1-octanol (C8) for the formation of the microemulsions. Read More

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December 2018

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

Pathways modulating glucose homeostasis independently of insulin would open new avenues to combat insulin resistance and diabetes. Here, we report the establishment, characterization and use of a vertebrate 'insulin-free' model to identify insulin-independent modulators of glucose metabolism. knockout zebrafish recapitulate core characteristics of diabetes and survive only up to larval stages. Read More

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December 2018

The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etoposide reveals a profound dysregulation of the DNA damage response, including upstream regulators and downstream p53 targets. Read More

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December 2018

Difficulties regulating emotions mediates the associations of parental psychological control and emotion invalidation with borderline personality features.

Personal Disord 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology.

Extant research has supported a connection between socialization in childhood and difficulties regulating emotions. The biosocial theory of borderline personality disorder (BPD; Crowell, Beauchaine, & Linehan, 2009; Linehan, 1993) suggests that emotion dysregulation is a core mechanism underlying the extreme behaviors, mood instability, identity disturbance, and relationship instability observed in BPD. The present study investigated the impact of socialization factors related to emotions, parental autonomy support, parental psychological control, and childhood trauma on BPD features in a nonclinical young adult sample (N = 357). Read More

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December 2018

Fragmentation of Valence and Carbon Core Excited and Ionized CHFCF Molecule.

J Phys Chem A 2018 Dec 6. Epub 2018 Dec 6.

The photofragmentation dynamics of 1,1,1,2-tetrafluoroethane (R134a) with photon energies from 12 eV up to 320 eV, surrounding the C 1s edge is discussed. The ionic moieties were measured according to their mass to charge ratio, in coincidence with the photoelectrons (PEPICO mode), and collected as a function of the incident photon energy. In the C K core region, the fragmentation patterns are examined in terms of site specific excitation of the CH2FCF3 molecule. Read More

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December 2018

A Biomimetic Approach Towards Enterocin and Deoxyenterocin.

J Org Chem 2018 Dec 6. Epub 2018 Dec 6.

Enterocin (vulgamycin) is a structurally remarkable natural product with significant antibiotic activity. The synthesis of a linear polyketide resembling a biosynthetic precursor was achieved using an unusual acyloin reaction. A diazo group was introduced as a protecting group for an enolizable ketone. Read More

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December 2018

Colloidal FeIII, MnIII, CoIII and CuII hydroxides stabilized by starch as catalysts of water oxidation reaction with one electron oxidant Ru(bpy)33.

Chemphyschem 2018 Dec 6. Epub 2018 Dec 6.

Boreskov Institute of Catalysis RAS, pr. Lavrenteva 5, 630000, Novosibirsk, RUSSIAN FEDERATION.

Colloidal catalysts for water oxidation to dioxygen, which are stable on storage and under the reaction conditions, are synthesized based on CoIII, MnIII, FeIII and CuII hydroxides. Stabilization of the colloids with dextrated starch allows the process of hydroxide ageing to be stopped at the stage of the formation of primary nuclei (ca. 2-3 nm from TEM data). Read More

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December 2018

Solving for X: Evidence for sex-specific autism biomarkers across multiple transcriptomic studies.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 6. Epub 2018 Dec 6.

Centre for Pattern Recognition and Data Analytics (PRaDA), Deakin University, Geelong, Australia.

Autism spectrum disorder (ASD) is a markedly heterogeneous condition with a varied phenotypic presentation. Its high concordance among siblings, as well as its clear association with specific genetic disorders, both point to a strong genetic etiology. However, the molecular basis of ASD is still poorly understood, although recent studies point to the existence of sex-specific ASD pathophysiologies and biomarkers. Read More

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December 2018
1 Read

Residue-level determinants of Angiopoietin-2 interactions with its receptor Tie2.

Proteins 2018 Dec 6. Epub 2018 Dec 6.

Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.

We combined computational and experimental methods to interrogate the binding determinants of Angiopoietin-2 (Ang2) to its receptor tyrosine kinase (RTK) Tie2 - a central signaling system in angiogenesis, inflammation, and tumorigenesis. We employed physics-based electrostatic and surface-area calculations to identify the subset of interfacial Ang2 and Tie2 residues that can affect binding directly. Using random and site-directed mutagenesis and yeast surface display (YSD), we validated these predictions and identified additional Ang2 positions that affected receptor binding. Read More

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December 2018

Copper(i)-polymers and their photoluminescence thermochromism properties.

Photochem Photobiol Sci 2018 Dec 6. Epub 2018 Dec 6.

College of Chemistry, and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, Jilin 130012, China.

Under hydro(solvo)thermal conditions, four organic bidentate bridging N,N'-donor ligands 1,3-bis(2-methylimidazol-1-yl)propane (L1), 4,4'-di(1H-imidazol-1-yl)-1,1'-biphenyl (L2), 1,2-bis(2-methyl-1H-imidazol-1-ylmethyl)benzene (L3) and 5,6,7,8-tetrahydroquinoxaline (L4) were employed to react with CuBr/CuI, generating four 2-D layered copper(i)-polymer coordination polymer materials [Cu2Br2(L1)] 1, [CuI(L2)] 2, [CuI(L3)] 3 and [CuI(L4)0.5] 4. In 1-4, different Cu-X motifs are found: a cubic Cu4Br4 core in 1; a castellated Cu-I single chain in 2; a rhombic Cu2I2 core in 3; and a staircase-like Cu-I double chain in 4. Read More

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December 2018

Acute effects of core stability exercises on balance control.

Acta Bioeng Biomech 2018 ;20(4):145-151

Department of Biomechanics, Opole University of Technology, Opole, Poland.

Purpose: The aim of this study was to investigate whether a single bout of core stability exercises improves body balance immediately after the bout of exercise and during a retention test.

Methods: The study involved 16 women (age 22-25 years, body weight 60.5 ± 5. Read More

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January 2018

Vapreotide-mediated hierarchical mineralized Ag/Au nanoshells for photothermal anti-tumor therapy.

Nanotechnology 2019 Feb;30(5):055602

Applied Chemistry Key Lab of Hebei Province, Department of Bioengineering, Yanshan University, Qinhuangdao 066004, People's Republic of China. Asparagus Industry Technology Research Institute of Hebei Province, Qinhuangdao 066004, People's Republic of China.

A new type of vapreotide-templated Ag/Au bimetallic nanoshells (Vap@Ag/AuNSs) were successfully designed and fabricated based on polypeptide-directed mineralization and hierarchical self-assembly mechanisms under mild synthetic conditions. The nanoparticles with polypeptides serving as a core and coated Ag/Au bimetallic nanoshells exhibit diverse advantages, such as excellent biocompatibility, tumor targeting and low-cost. The Vap@Ag/AuNSs share excellent dispersibility, uniform size (120 nm) and a positive zeta potential (36. Read More

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February 2019
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Fabrication of step-by-step drug release system both sensitive to magnetic field and temperature based on layered double hydroxides and PNIPAM.

Nanotechnology 2019 Feb;30(5):055103

School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing, People's Republic of China.

Fabrication of environmental sensitive and controllable drug release systems is urgently needed. In this paper, thermosensitive and magnetic response drug release systems were fabricated via layer-by-layer technique using acetylsalicylic acid (AA) intercalated ZnAl-LDH as core, poly (N-isopropylacrylamide) (PNIPAM) and AA micelles as well as small size ZnAl-LDH sheets as building blocks of the shell. By forming anionic micelles, cationic PNIPAM macromolecules were sandwiched in the LDH sheets with cationic charges which provided a novel way of fabrication of drug release systems. Read More

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February 2019

Abstract 79: Chronic and Acute Hypertension in Ischemic Stroke Are Distinct Markers of Impaired Collateral Circulation.

Stroke 2018 Jan;49(Suppl_1):A79

Univ of Vermont, Burlington, VT.

Background: Acute blood pressure (BP) elevation in acute ischemic stroke (AIS) is common, yet the link with collateral circulation remains elusive due to lack of longitudinal data on premorbid hypertension (HTN) and serial BP changes within an individual. Precision medicine for AIS and management of HTN requires an understanding of collateral circulation.

Methods: The Interventional Management of Stroke III angiography core lab prospectively evaluated collateral circulation utilizing the ASITN scale prior to endovascular therapy. Read More

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January 2018
1 Read

Incidental Hepatic Tissue Obtained via Routine Cholecystectomy.

Int J Surg Pathol 2018 Dec 6:1066896918817374. Epub 2018 Dec 6.

2 University of California, Irvine, CA, USA.

Background: The hepatic tissue that may occupy specimens from routine cholecystectomies has yet to be studied. Our objectives were to determine the prevalence of hepatic tissue obtained at routine cholecystectomy, to determine whether such hepatic tissue can histologically withstand technical artifacts commonly associated with cholecystectomy, and to determine whether examining such hepatic tissue has diagnostic utility.

Materials And Methods: We retrospectively reviewed 50 specimens from routine cholecystectomies that were performed by surgeons who lacked knowledge of our study. Read More

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December 2018
1 Read

The folding and aggregation energy landscapes of tethered RRM domains of human TDP-43 are coupled via a metastable molten globule-like oligomer.

Biochemistry 2018 Dec 6. Epub 2018 Dec 6.

Stress-induced misfolding and intraneuronal aggregation of the highly conserved nucleic acid binding protein TDP-43 (transactive response DNA binding protein 43 kDa) and its fragments have been implicated in amyotrophic lateral sclerosis and multiple other neurodegenerative diseases. However, the physico-chemical mechanism of its misfolding from the functional folded state is poorly understood. TDP-43 is a four domain protein and it performs the essential nucleic acid binding function with the help of its two tandem RNA recognition motif domains naturally tethered by a linker (called here tethered RRM domain of TDP-43 or TDP-43). Read More

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December 2018

Response shift effects of quality of life assessments in breast cancer survivors.

Eur J Cancer Care (Engl) 2018 Dec 6:e12979. Epub 2018 Dec 6.

Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.

Measurements of quality of life (QoL) can be distorted by respondents adapting to new situations between measurement points and consequently having a changed frame of reference. To investigate this bias in breast cancer survivors, we compare their QoL with that of the general population and use two complementary methods for detecting this bias. Breast cancer survivors (n = 308, response rate: 91%) were tested with the QoL questionnaire European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30. Read More

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December 2018

A core outcome set for the evaluation of treatments for twin-twin transfusion syndrome.

Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.

Background: A minimum data set, known as a core outcome set, should standardise outcome selection, collection, and reporting across future twin-to-twin transfusion syndrome research.

Methods: An international steering group including healthcare professionals, researchers, and patients, guided the development of this core outcome set. Potential core outcomes, identified through a comprehensive literature review, were entered into a three round Delphi survey. Read More

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December 2018
1 Read

CD8 cytotoxic T lymphocytes in cancer immunotherapy: A review.

J Cell Physiol 2018 Nov 22. Epub 2018 Nov 22.

Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

CD8 cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immunerelated tolerance and immunosuppression within the tumor microenvironment (TME), with all favor adaptive immune-resistance. Cancer-associated fibroblasts (CAFs), macrophage type 2 (M2) cells, and regulatory T cells (Tregs) could make immunologic barriers against CD8 T cell-mediated antitumor immune responses. Read More

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November 2018
1 Read

A validated workflow for drug detection in oral fluid by non-targeted liquid chromatography-tandem mass spectrometry.

Anal Bioanal Chem 2018 Dec 6. Epub 2018 Dec 6.

Institute of Legal Medicine and Core Facility Metabolomics, Medical University of Innsbruck, Muellerstr. 44, 6020, Innsbruck, Austria.

Oral fluid is recognized as an important specimen for drug testing. Common applications are monitoring in substance abuse treatment programs, therapeutic drug monitoring, pain management, workplace drug testing, clinical toxicology, and driving under the influence of drugs (DRUID). In this study, we demonstrate that non-targeted LC-MS/MS with subsequent compound identification by tandem mass spectral library search is a valuable tool for comprehensive detection and confirmation of drugs in oral fluid samples. Read More

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December 2018

Apocrine papillary lesion: comparison of pathological findings from 22 years previously and the present.

Breast Cancer 2018 Dec 5. Epub 2018 Dec 5.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Hospital, Kagoshima, Japan.

Apocrine papillary lesion (APL) is difficult to diagnose as benign or malignant. We experienced an APL remaining in the body for 22 years. We present a case of a 71-year-old woman who had undergone excisional biopsy 22 years previously at the first hospital that she visited. Read More

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December 2018

Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis.

Sci China Life Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Cardiology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.

Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock, with mortality rates as high as 50%-70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Read More

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December 2018
2 Reads

Effect of transcutaneous vagus nerve stimulation on muscle activity in the gastrointestinal tract (transVaGa): a prospective clinical trial.

Int J Colorectal Dis 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, University Hospital of Bonn, Bonn, Germany.

Purpose: Postoperative ileus (POI) is a common complication after abdominal surgery. Invasive stimulation of the cervical vagus nerve is known to reduce inflammatory response and ameliorated POI after surgery in a mouse model. However, the transcutaneous vagus nerve stimulation (tVNS) is a possible non-invasive approach. Read More

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December 2018
1 Read

Two ancient neuropeptides, PACAP and AVP, modulate motivated behavior at synapses in the extrahypothalamic brain: a study in contrast.

Cell Tissue Res 2018 Dec 5. Epub 2018 Dec 5.

Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, NIMH-IRP, Building 49, Room 5A-32, 9000 Rockville Pike, Bethesda, MD, USA.

We examine evolutionary aspects of two primordial neuropeptides, arginine vasopressin (AVP) and pituitary adenylate cyclase-activating polypeptide (PACAP); the distribution of AVP and PACAP and their receptors in mammals; AVP and PACAP release patterns relevant to their roles in neuroendocrine control in brain and periphery; and finally the intricate interlocking of homeostatic and allostatic regulation created by extrahypothalamic AVP and PACAP projections to brain circuit nodes important in controlling appetitive, avoidance and aggressive motor responses. A cardinal feature of peptide neurotransmission important in regulatory control of organismic responses and emphasized in this review, is that neuropeptides are released from large dense-core vesicles docked not only within axonal varicosities and dendrites but also at presynaptic nerve terminal sites, along with small clear synaptic vesicles, at active zones. Peptide transmitter nerve terminals, from hypothalamic and other projections, are distributed widely to multiple brain areas important in integrative control of behavior. Read More

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December 2018

Rapid identification of specific DNA aptamers precisely targeting CD33 positive leukemia cells through a paired cell-based approach.

Biomater Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, P.R. China and Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou 310058, P.R. China.

Aptamers are short single-stranded DNA or RNA molecules, which have recently been developed for potential broad applications such as clinical therapeutics, diagnosis and tumor-targeted drug delivery. However, the selection of specific aptamers is often unsatisfactory using the classical protein or cell-based SELEX. Herein, we modified the paired cell line approach to identify aptamers targeting leukemia cells expressing the CD33 antigen. Read More

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December 2018

A carnivorous plant genetic map: pitcher/insect-capture QTL on a genetic linkage map of .

Life Sci Alliance 2018 Dec 29;1(6):e201800146. Epub 2018 Nov 29.

Department of Plant Biology, Miller Plant Sciences Building, University of Georgia, Athens, GA, USA.

The study of carnivorous plants can afford insight into their unique evolutionary adaptations and their interactions with prokaryotic and eukaryotic species. For (pitcher plants), we identified 64 quantitative trait loci (QTL) for insect-capture traits of the pitchers, providing the genetic basis for differences between the pitfall and lobster-trap strategies of insect capture. The linkage map developed here is based upon the F2 of a cross between and ; we mapped 437 single nucleotide polymorphism and simple sequence repeat markers. Read More

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December 2018
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Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum.

Life Sci Alliance 2018 Dec 3;1(6):e201800062. Epub 2018 Dec 3.

Division of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Peroxisome biogenesis disorders (PBDs) manifest as neurological deficits in the central nervous system, including neuronal migration defects and abnormal cerebellum development. However, the mechanisms underlying pathogenesis remain enigmatic. Here, to investigate how peroxisome deficiency causes neurological defects of PBDs, we established a new PBD model mouse defective in peroxisome assembly factor Pex14p, termed mouse. Read More

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December 2018

Stroke: The past, present and future.

Brain Neurosci Adv 2018 ;2:2398212818810689

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Since the inception of the British Neuroscience Association, there have been major advances in our knowledge of the mechanistic basis for stroke-induced brain damage. Identification of the ischaemic cascade led to the development of hundreds of new drugs, many showing efficacy in preclinical (animal-based) studies. None of these drugs has yet translated to a successful stroke treatment, current therapy being limited to thrombolysis/thrombectomy. Read More

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January 2018

Derivation and Validation of the Potential Core Genes in Pancreatic Cancer for Tumor-Stroma Crosstalk.

Biomed Res Int 2018 5;2018:4283673. Epub 2018 Nov 5.

Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.

Background: Pancreatic cancer is a fatal malignancy with a poor prognosis. The interactions between tumor cells and stromal cells contribute to cancer progression. Pancreatic stellate cells (PSCs) play a key role in tumor-stroma crosstalk of pancreatic cancer. Read More

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November 2018

Local Tensile Stress in the Development of Posttraumatic Osteoarthritis.

Biomed Res Int 2018 4;2018:4210353. Epub 2018 Nov 4.

Orthopedic Institute, Medical College, Soochow University, Suzhou, Jiangsu 215006, China.

The pathogenesis of posttraumatic osteoarthritis (PTOA) remains unrevealed. We speculate that cartilage crack caused by joint trauma will induce local abnormal tensile stress, leading to change in extracellular matrix (ECM) expression of chondrocytes, cartilage degeneration, and initiation of osteoarthritis. Finite element model was used to examine whether the local tensile stress could be produced around the crack. Read More

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November 2018