52,017 results match your criteria Cor Pulmonale


Non-Apnea Sleep Disorder associates with increased risk of incident heart failure-A nationwide population-based cohort study.

PLoS One 2019 16;14(1):e0209673. Epub 2019 Jan 16.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Purpose: Non-apnea sleep disorder (NASD) increases the risk of cardiovascular events, such as hypertension and ischemic heart disease (IHD). Patients with heart failure (HF) are at higher risk for sleep disorder; however, there is no documentation on NASD's association with HF to date. Therefore, our study aimed to determine whether NASD increases the risk of incident HF. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209673PLOS
January 2019

Chronic kidney disease predicts atrial fibrillation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.

Acta Cardiol 2019 Jan 16:1-8. Epub 2019 Jan 16.

a University of Medicine and Pharmacy of Tîrgu Mureș , Tîrgu Mureș , Romania.

Background: Atrial fibrillation (AF) often complicates ST-segment elevation myocardial infarction (STEMI). Predictors of AF in this setting include factors related to the acute phase of STEMI and pre-existing conditions. More recently, novel AF predictors have been identified in the general population. Read More

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http://dx.doi.org/10.1080/00015385.2018.1521558DOI Listing
January 2019

Heart failure and chronic obstructive pulmonary disease: a review.

Acta Cardiol 2019 Jan 16:1-8. Epub 2019 Jan 16.

a Internal Medicine Clinic , Clinical Emergency Hospital of Bucharest , Bucharest , Romania.

Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are important causes of morbidity and mortality worldwide. The association between the two conditions have significant systemic effects and a chronic, progressive evolution, affecting exercise tolerance and quality of life. The diseases share common risk factors, such as smoking, advanced age, and low-grade systemic inflammation. Read More

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http://dx.doi.org/10.1080/00015385.2018.1559485DOI Listing
January 2019

Initial experience with cinematic rendering for the visualization of extracardiac anatomy in complex congenital heart defects.

Interact Cardiovasc Thorac Surg 2019 Jan 16. Epub 2019 Jan 16.

Department of Pediatric Cardiology, University Hospital Erlangen, Erlangen, Germany.

Objectives: Detailed anatomical information is essential for planning of surgical therapy in patients with congenital heart disease. We wanted to determine whether cinematic rendering, the novel 3-dimensional visualization technique, could help paediatric cardiac surgeons achieve better preoperative visualization of the extracardiac anatomy in patients with complex congenital heart defects. Therefore, cinematic rendering was compared to the traditional volume rendering technique by means of a questionnaire with predefined criteria. Read More

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http://dx.doi.org/10.1093/icvts/ivy348DOI Listing
January 2019

Burden and causes for hospitalizations following coronary artery bypass grafting: a nationwide cohort study.

Eur J Cardiothorac Surg 2019 Jan 10. Epub 2019 Jan 10.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Hospitalizations are a major burden for both patients and society and are potentially preventable. However, data on the burden and causes for hospitalizations after coronary artery bypass grafting (CABG) are sparse. We examined hospitalizations within 1 year after CABG and associated factors. Read More

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http://dx.doi.org/10.1093/ejcts/ezy418DOI Listing
January 2019

Cardiovascular Risk Factors Associated With Venous Thromboembolism.

JAMA Cardiol 2019 Jan 16. Epub 2019 Jan 16.

London School of Hygiene and Tropical Medicine, London, United Kingdom.

Importance: It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE).

Objective: To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism.

Design, Setting, And Participants: This study included individual participant data mostly from essentially population-based cohort studies from the Emerging Risk Factors Collaboration (ERFC; 731 728 participants; 75 cohorts; years of baseline surveys, February 1960 to June 2008; latest date of follow-up, December 2015) and the UK Biobank (421 537 participants; years of baseline surveys, March 2006 to September 2010; latest date of follow-up, February 2016). Read More

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http://dx.doi.org/10.1001/jamacardio.2018.4537DOI Listing
January 2019

The Diagnostic Tests for Detection of Helicobacter pylori Infection.

Monoclon Antib Immunodiagn Immunother 2019 Jan 16. Epub 2019 Jan 16.

1 Department of Microbiology, Shahr-e-Qods-Branch, Islamic Azad University, Tehran, Iran.

Helicobacter pylori causes one of the most common infections in human populations. The role of this bacterium in chronic gastritis, gastric ulcer, gastric cancer, as well as extra-digestive diseases such as ischemic heart disease and chronic obstructive pulmonary diseases, is well known. Prevention and control of these diseases can occur by early diagnosis and eradication of H. Read More

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http://dx.doi.org/10.1089/mab.2018.0032DOI Listing
January 2019

Differences in clinical characteristics and one-year outcomes of hospitalized heart failure patients in succeeding European Society of Cardiology-Heart Failure Registries - Pilot and Long-Term.

Pol Arch Intern Med 2019 Jan 16. Epub 2019 Jan 16.

INTRODUCTION The management of heart failure (HF) has significantly changed in recent decades. OBJECTIVES The paper analyzes clinical profile, one-year outcomes, predictors of mortality and hospital readmissions in hospitalized patients enrolled in the European Society of Cardiology HF-Pilot (ESC-HF-Pilot) and HF-Long Term (ESC-HF-LT) Registries. PATIENTS AND METHODS The analysis included hospitalized Polish patients from the ESC-HF-Pilot and ESC-HF-LT Registries. Read More

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http://dx.doi.org/10.20452/pamw.4418DOI Listing
January 2019

Unusual Sequence of Events in a Case of Takotsubo Syndrome.

Case Rep Cardiol 2018 13;2018:5498052. Epub 2018 Dec 13.

Department of Cardiology, Maimonides Medical Center, Brooklyn, NY 11219, USA.

A 73-year-old female with multiple comorbidities including coronary artery disease was admitted for an elective PCI of a lesion detected in the RCA. On the day of the planned PCI, shortly after right femoral artery cannulation, the patient developed a sudden complete heart block requiring the administration atropine and insertion of a temporary pacemaker. Concomitantly, the patient developed acute pulmonary edema, hypotension, and hypoxia requiring intubation for mechanical ventilation. Read More

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http://dx.doi.org/10.1155/2018/5498052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311793PMC
December 2018

Clinical Determinants and Prognostic Implications of Right Ventricular Dysfunction in Pulmonary Hypertension Caused by Chronic Lung Disease.

J Am Heart Assoc 2019 Jan;8(2):e011464

1 Cardiovascular Division University of Minnesota Medical School Minneapolis MN.

Background Patients with pulmonary hypertension caused by chronic lung disease (Group 3 PH ) have disproportionate right ventricle ( RV ) dysfunction, but the correlates and clinical implications of RV dysfunction in Group 3 PH are not well defined. Methods and Results We performed a cohort study of 147 Group 3 PH patients evaluated at the University of Minnesota. RV systolic function was quantified using right ventricular fractional area change ( RVFAC ) and dP /dt/instantaneous pressure. Read More

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http://dx.doi.org/10.1161/JAHA.118.011464DOI Listing
January 2019

Elucidation of Vasodilation Response and Structure Activity Relationships of ²,⁴Disubstituted Quinazoline 2,4-Diamines in a Rat Pulmonary Artery Model.

Molecules 2019 Jan 14;24(2). Epub 2019 Jan 14.

Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.

Pulmonary arterial hypertension (PAH) is a rare and progressive disease arising from various etiologies and pathogenesis. PAH decreases life expectancy due to pulmonary vascular remodeling, elevation of mean pulmonary arterial pressure, and ultimately progresses to heart failure. While clinical treatments are available to reduce the associated symptoms, a complete cure has yet to be found. Read More

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http://dx.doi.org/10.3390/molecules24020281DOI Listing
January 2019

Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease.

JAMA Netw Open 2018 Dec 7;1(8):e185489. Epub 2018 Dec 7.

Leicester Diabetes Centre, University of Leicester, Leicester, United Kingdom.

Importance: In heart failure (HF), chronic obstructive pulmonary disease (COPD) increases the risk of poor outcomes, but the effect of COPD severity is unknown. This information is important for early intervention tailored to the highest-risk groups.

Objectives: To determine the associations between COPD medication intensity or stage of airflow limitation and the risk of hospitalization or death in patients with HF. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.5489DOI Listing
December 2018
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Misclassification of Both Chronic Obstructive Pulmonary Disease and Heart Failure.

JAMA Netw Open 2018 Dec 7;1(8):e185486. Epub 2018 Dec 7.

Julius Center for Health Sciences and Primary Care, Department of General Practice, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.5486DOI Listing
December 2018

Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission.

JAMA Netw Open 2018 Aug 3;1(4):e181405. Epub 2018 Aug 3.

Center of Innovation in Long Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, Rhode Island.

Importance: Delirium at admission is associated with increased hospital morbidity and mortality, but it may be missed in up to 70% of cases. Use of a predictive algorithm in an electronic medical record (EMR) system could provide critical information to target assessment of those with delirium at admission.

Objectives: To develop and assess a prediction rule for delirium using 2 populations of veterans and compare this rule with previously confirmed rules. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.1405DOI Listing
August 2018
1 Read

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, .

Elife 2019 Jan 15;8. Epub 2019 Jan 15.

Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, United States.

CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of as a proof of principle. This secreted ribonuclease is crucial for Th2 polarization and granuloma formation. Read More

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http://dx.doi.org/10.7554/eLife.41337DOI Listing
January 2019

[Treatment strategies for congenital heart disease in infants with severe pneumonia].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1241-1245

Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To observe the results of different treatment of congenital heart disease (CHD) complicated with severe pneumonia in infants.
 Methods: A total of 27 infants with CHD and severe pneumonia were admitted to the Department of Pediatrics, Xiangya Hospital from January 2014 to December 2014, of whom 18 were male and 9 were female. The average age was 2. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.11.012DOI Listing
November 2018

Rate of instrumentation changes on postoperative and follow-up radiographs after primary complex spinal fusion (five or more levels) for adult deformity correction.

J Neurosurg Spine 2019 Jan 11:1-6. Epub 2019 Jan 11.

2Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.

OBJECTIVEIn the United States, healthcare expenditures have been soaring at a concerning rate. There has been an excessive use of postoperative radiographs after spine surgery and this has been a target for hospitals to reduce unnecessary costs. However, there are only limited data identifying the rate of instrumentation changes on radiographs after complex spine surgery involving ≥ 5-level fusions. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18686DOI Listing
January 2019

Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement.

Am J Respir Crit Care Med 2018 Dec;198(12):e116-e136

Background: Thousands of biomarker tests are either available or under development for lung diseases. In many cases, adoption of these tests into clinical practice is outpacing the generation and evaluation of sufficient data to determine clinical utility and ability to improve health outcomes. There is a need for a systematically organized report that provides guidance on how to understand and evaluate use of biomarker tests for lung diseases. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201810-1895ST
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http://dx.doi.org/10.1164/rccm.201810-1895STDOI Listing
December 2018
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Roles of TRPA1 and TRPV1 in Cigarette Smoke -induced Airway Epithelial Cell Injury Model.

Free Radic Biol Med 2019 Jan 9. Epub 2019 Jan 9.

Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, NO.241, West HuaiHai Road, Shanghai, 200030, P.R.China. Electronic address:

Transient receptor potential protein (TRP) ion channels TRPA1 and TRPV1 may be important in mediating airway tissue injury and inflammation. This study was designed to clarify the role of TRPA1 and TRPV1 channels in cigarette smoke extract (CSE)-induced damage to bronchial and alveolar epithelial cells. Alveolar epithelial (A549) cells and bronchial epithelial (Beas-2B) cells were treated with CSE in the presence and absence of a TRPA1 inhibitor (100μM, A967079), a TRPV1 inhibitor (100μM, AMG9810) or both. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.004DOI Listing
January 2019

The Modified 5-item Frailty Index (mFI-5) - a concise and useful tool for assessing the impact of frailty on post-operative morbidity following elective posterior lumbar fusions (PLF).

World Neurosurg 2019 Jan 10. Epub 2019 Jan 10.

Department of Orthopaedics, The Ohio State University Wexner Medical Center. Electronic address: https://spine.osu.edu/about/our-team.

Background: The modified 5-item frailty index (mFI-5) is a concise co-morbidity based risk stratification tool that has been shown to predict the occurrence of adverse outcomes following various orthopaedic surgeries.

Methods: The 2012-2016 American College of Surgeons - National Surgical Quality Improvement Program (ACS-NSQIP) dataset was used to identify patients undergoing an elective 1-to-2 level posterior lumbar fusion for degenerative lumbar pathology. The mFI-5 score was calculated on the basis of the presence of the five co-morbidities - congestive heart failure within 30 days prior to surgery, insulin-dependent or non-insulin dependent diabetes mellitus, chronic obstructive pulmonary disease or pneumonia, partially dependent or totally dependent functional health status at time of surgery and hypertension requiring medication. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193003
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http://dx.doi.org/10.1016/j.wneu.2018.12.168DOI Listing
January 2019
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Dexamethasone improves pulmonary hemodynamics in COPD-patients going to altitude: A randomized trial.

Int J Cardiol 2018 Dec 28. Epub 2018 Dec 28.

Clinic of Pulmonology, University Hospital Zurich, Switzerland; Centre for Integrative Human Physiology, University of Zurich, Switzerland. Electronic address:

Background: Chronic obstructive pulmonary disease (COPD) may predispose to symptomatic pulmonary hypertension at high altitude. We investigated hemodynamic changes in lowlanders with COPD ascending rapidly to 3100 m and evaluated whether preventive dexamethasone treatment would mitigate the altitude-induced increase in pulmonary artery pressure.

Methods: In this placebo-controlled, double-blind trial, non-hypercapnic COPD patients living <800 m, were randomized to receive either dexamethasone (8 mg/day) or placebo tablets one day before ascent from 760 m and during a 3-day-stay at 3100 m. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.12.052DOI Listing
December 2018

Renin-angiotensin-aldosterone system blockade in systemic right ventricle.

Int J Cardiol 2019 Jan 6. Epub 2019 Jan 6.

Cincinnati Children's Hospital, Cincinnati, USA; University Health Network, Peter Munk Cardiac Centre, Toronto Congenital Cardiac Centre for Adults, and University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.ijcard.2019.01.003DOI Listing
January 2019

Takayasu arteritis: differential diagnosis in a teenager with severe acute kidney injury - a case report.

J Bras Nefrol 2019 Jan 10. Epub 2019 Jan 10.

Hospital Geral de Fortaleza, Departamento de Nefrologia, Fortaleza, CE, Brasil.

Takayasu arteritis (TA) is a chronic granulomatous inflammatory condition of unknown cause that involves large vessels - particularly the aorta and its branches - such as the carotid, coronary, pulmonary, and renal arteries. The left subclavian artery is the most frequently involved vessel. Stenosis of the renal artery has been reported in 23-31% of the cases and may result in malignant hypertension, ischemic renal disease, decompensated heart failure, and premature death. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0174DOI Listing
January 2019

Implantation of a Stent in a Stenotic Conduit Between the Left Ventricle and Aorta in a Patient Undergone Surgery for a Double Outlet Right Ventricle.

J Transl Int Med 2018 Dec 31;6(4):194-197. Epub 2018 Dec 31.

Department of Adult Cardiology, CHU-Brugmann, Brussels, Belgium.

Reinterventions for surgery complications in adult patients with complex congenital heart disease are often difficult and have a high operative risk. If anatomically possible, a percutaneous approach is an alternative to surgery. We report the case of a 36 year-old patient who underwent surgery for a double outlet right ventricle with transposition of the great arteries and pulmonary stenosis. Read More

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http://dx.doi.org/10.2478/jtim-2018-0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326031PMC
December 2018

Impact of preoperative pulmonary arterial hypertension on early and late outcomes in patients undergoing valve surgery for rheumatic heart disease.

Indian J Anaesth 2018 Dec;62(12):963-971

Department of Cardiac Anesthesia, Narayana Institute of Cardiac Sciences, Bengaluru, Karnataka, India.

Background And Aims: There is conflicting evidence on adverse effect of Pulmonary Arterial Hypertension (PAH) on outcomes after cardiac surgery for rheumatic heart disease (RHD). The authors studied Indian patients with RHD and preoperative PAH, who undergo cardiac surgery with a hypothesis that they have poor short and long-term outcomes.

Methods: This was a retrospective observational study of 407 patients. Read More

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http://dx.doi.org/10.4103/ija.IJA_374_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299764PMC
December 2018

Heart or heart-lung transplantation for patients with congenital heart disease in England.

Heart 2019 Jan 12. Epub 2019 Jan 12.

Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK.

Background: Increased longevity in patients with congenital heart disease (CHD) is associated with late complications, mainly heart failure, which may not be amenable to redo surgery and become refractory to medical therapy and so, trigger referral for transplantation. We assessed the current role and future prospects of heart and heart-lung transplantation for patients with CHD in England.

Methods: We performed a retrospective analysis of hospital episodes for England for 1997-2015, identifying patients with a CHD code (ICD-10 'Q2xx. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313984DOI Listing
January 2019

Evolution of hemodynamic forces in the pulmonary tree with progressively worsening pulmonary arterial hypertension in pediatric patients.

Biomech Model Mechanobiol 2019 Jan 12. Epub 2019 Jan 12.

Departments of Pediatrics and Bioengineering, Stanford University, Stanford, CA, USA.

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling resulting in right ventricular (RV) dysfunction and ultimately RV failure. Mechanical stimuli acting on the vessel walls of the full pulmonary tree have not previously been comprehensively characterized. The goal of this study is to characterize wall shear stress (WSS) and strain in pediatric PAH patients at different stages of disease severity using computational patient-specific modeling. Read More

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http://dx.doi.org/10.1007/s10237-018-01114-0DOI Listing
January 2019
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Gout as a Risk Factor for Dry Eye Disease: A Population-Based Cohort Study.

J Clin Med 2019 Jan 9;8(1). Epub 2019 Jan 9.

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

This study evaluated the effect of gout on the risk of dry eye disease (DED) by using the National Health Insurance Research Database (NHIRD). Data for 30,192 gout patients (21,081 men and 9111 women) and 30,192 non-gout patients (21,005 men and 9187 women) were analyzed. Approximately 1 million patients were randomly sampled from the NHIRD registry. Read More

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http://www.mdpi.com/2077-0383/8/1/62
Publisher Site
http://dx.doi.org/10.3390/jcm8010062DOI Listing
January 2019
2 Reads

Selexipag treatment for pulmonary arterial hypertension associated with congenital heart disease after defect correction: insights from the randomised controlled GRIPHON study.

Eur J Heart Fail 2019 Jan 11. Epub 2019 Jan 11.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University Hospital, Bologna, Italy.

Aims: Patients with pulmonary arterial hypertension associated with congenital heart disease (CHD-PAH) after defect correction have a poor prognosis compared with other CHD-PAH patients. Therefore, it is important that these patients are treated as early and effectively as possible. Evidence supporting the use of PAH therapies in patients with corrected CHD-PAH from randomised controlled trials is limited. Read More

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http://doi.wiley.com/10.1002/ejhf.1375
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http://dx.doi.org/10.1002/ejhf.1375DOI Listing
January 2019
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Iron deficiency in pulmonary arterial hypertension associated with congenital heart disease.

Scand Cardiovasc J 2019 Jan 11:1-18. Epub 2019 Jan 11.

a Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.

Objectives: We aimed to investigate the prevalence of iron deficiency (ID) in congenital heart disease associated with pulmonary arterial hypertension (CHD-PAH) and to explore the influence of ID on CHD-PAH patients. What was associated with ID in these patients was also looked into.

Design: 153 patients who were newly diagnosed with CHD-PAH were enrolled. Read More

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http://dx.doi.org/10.1080/14017431.2019.1567934DOI Listing
January 2019
1.104 Impact Factor

Influenza B virus infection complicated by life-threatening pericarditis: a unique case-report and literature review.

BMC Infect Dis 2019 Jan 10;19(1):40. Epub 2019 Jan 10.

Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, Rome, Italy.

Background: Acute pericarditis may occur frequently after viral infections. To our knowledge, influenza B virus infection complicated by pericarditis without myocardial involvement has never been reported. We report the first case of life-threatening pericarditis caused by influenza B virus infection. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3606-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327550PMC
January 2019
1 Read

Fontan Revision: Presurgical Planning Using Four-Dimensional (4D) Flow and Three-Dimensional (3D) Printing.

World J Pediatr Congenit Heart Surg 2019 Jan 10:2150135118799641. Epub 2019 Jan 10.

1 Division of Cardiology, Rady Children's Hospital/UCSD, San Diego, CA, USA.

Pulmonary arteriovenous malformations (AVMs) can be a complication of certain postoperative Fontan patients whose hepatic venous blood return is not distributed evenly to both lungs. A ten-year-old female, who had previously undergone staged single ventricle palliation for complex congenital heart disease, underwent a Fontan revision due to significant left-sided pulmonary AVMs and increasing arterial oxygen desaturation. The combination of four-dimensional flow cardiac magnetic resonance imaging and three-dimensional printing enabled presurgical planning for a Fontan takedown and diversion of hepatic venous flow to the azygous vein that resulted in significant clinical improvement. Read More

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http://dx.doi.org/10.1177/2150135118799641DOI Listing
January 2019

Transcatheter redirection of hepatic venous blood to treat unilateral pulmonary arteriovenous malformations in a Fontan circulation by short-term total exclusion of the unaffected lung.

Catheter Cardiovasc Interv 2019 Jan 10. Epub 2019 Jan 10.

Division of Pediatric Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.

Clinically significant unilateral pulmonary arteriovenous malformations (PAVM) can develop in patients with a Fontan circulation when there is unbalanced distribution of hepatic venous (HV) blood flow to the lungs. There are reported surgical and transcatheter techniques to treat PAVMs by rerouting HV return, with promising short-term results. We report a case of a novel, technically simple transcatheter approach to redirect HV blood flow in an adult Fontan patient with polysplenia syndrome and severe unilateral PAVMs. Read More

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http://dx.doi.org/10.1002/ccd.28073DOI Listing
January 2019

Determinants of depressive mood in coronary artery disease patients with obstructive sleep apnea and response to continuous positive airway pressure treatment in non-sleepy and sleepy phenotypes in the RICCADSA cohort.

J Sleep Res 2019 Jan 9:e12818. Epub 2019 Jan 9.

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

We explored determinants of depressive mood in adults with coronary artery disease and obstructive sleep apnea and response to positive airway pressure treatment in sleepy and non-sleepy phenotypes. In this secondary analysis of the RICCADSA trial conducted in Sweden, 493 cardiac patients with obstructive sleep apnea (n = 386) or no obstructive sleep apnea (n = 107) with complete Epworth Sleepiness Scale and Zung Self-rating Depression Scale questionnaires were included. Sleepy (Epworth Sleepiness Scale ≥10) versus non-sleepy (Epworth Sleepiness Scale <10) patients with depressive mood (Zung Self-rating Depression Scale score ≥50) were evaluated after 3 and 12 months of positive airway pressure treatment. Read More

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http://doi.wiley.com/10.1111/jsr.12818
Publisher Site
http://dx.doi.org/10.1111/jsr.12818DOI Listing
January 2019
1 Read

Hyperthyroidism with Biventricular Heart Failure and Cirrhotic Transformation of the Liver.

Case Rep Cardiol 2018 9;2018:3861340. Epub 2018 Dec 9.

Reading Hospital, Tower Health System, West Reading, PA, USA.

Cardiovascular symptoms remain the most common presenting features and leading causes of death in hyperthyroidism. We report a young female with reported thyroid disease and medication noncompliance presenting with atrial fibrillation, severe atrioventricular regurgitation, severely dilated right heart with reduced function, and moderate pulmonary hypertension (PH), which was further complicated by congestive liver injury with ascites and pancytopenia. Thyroid work-up revealed suppressed TSH, elevated free T4 and T3 along with elevated anti-thyroglobulin antibodies, thyroid peroxidase antibodies, and thyroid-stimulating immunoglobulin, suggesting Graves' thyrotoxicosis. Read More

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http://dx.doi.org/10.1155/2018/3861340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305034PMC
December 2018

Increased physiological dead space at exercise is a marker of mild pulmonary or cardiovascular disease in dyspneic subjects.

Eur Clin Respir J 2018 5;5(1):1492842. Epub 2018 Jul 5.

Université Paris Diderot, PRES Sorbonne Paris Cité, Paris, France.

: The characteristics of cardiopulmonary exercise testing (CPET)-derived parameters for the differential diagnosis of exertional dyspnea are not well known. We hypothesized that increased physiological dead space ventilation (VD/Vt) is a marker for mild pulmonary or cardiovascular disease in patients with exertional dyspnea. We used receiver operating characteristic analysis to determine the performance of individual CPET parameters for identifying subjects with either mild pulmonary or cardiovascular disease, among 77 subjects with mild-to-moderate exertional dyspnea (modified Medical Research Council scale 1-2). Read More

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http://dx.doi.org/10.1080/20018525.2018.1492842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314086PMC

[Senile rheumatoid arthritis associated with rheumatoid lung: a caricatural observation].

Pan Afr Med J 2018 6;30:253. Epub 2018 Aug 6.

Service de Médecine Interne B, Hôpital Charles Nicolle, Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunis, Tunisie.

In the elderly, rheumatoid arthritis is defined by an average age of onset over 60 years. Prognosis mainly depends upon functional capacity, evolutionary stage of the disease, onset or no onset of joint malformations. We report the case of a 70-year old female patient with a history of arterial hypertension, hypothyroidism and Sjögren syndrome diagnosed in 2005. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.253.16372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307917PMC
August 2018
1 Read

[Interauricular communications in children: diagnosis and treatment, about 49 cases at the Children?s University Hospital in Dakar].

Pan Afr Med J 2018 2;30:245. Epub 2018 Aug 2.

Service de Chirurgie Thoracique et Cardio-vasculaire, Hôpital de Fann, UCAD, Dakar, Sénégal.

Interauricular communication (IAC) is the second most important congenital heart disease in children. It accounts for 6-8% of congenital cardiac malformations in children. However, many questions are still open about this pathology. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.245.14556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307921PMC

Total anomalous pulmonary vein drainage in a 60-year-old woman diagnosed in an ECG-gated multidetector computed tomography - a case report and review of literature.

Pol J Radiol 2018 5;83:e334-e339. Epub 2018 Jul 5.

I Department of Medical Radiology, Medical University of Lublin, Lublin, Poland.

Purpose: Total anomalous pulmonary vein drainage (TAPVD) is a congenital cardiac defect in which there is no connection between pulmonary veins and the left atrium. Pulmonary veins form a confluence independent of the left atrium and drain to a systemic vein. TAPVD types are: supracardiac, cardiac, infracardiac, and mixed. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.77696
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http://dx.doi.org/10.5114/pjr.2018.77696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323547PMC
July 2018
1 Read

Human PAH is characterized by a pattern of lipid-related insulin resistance.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Cardiovascular Medicine Division, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: Pulmonary arterial hypertension (PAH) is a deadly disease of the small pulmonary vasculature with an increased prevalence of insulin resistance (IR). Insulin regulates both glucose and lipid homeostasis. We sought to quantify glucose- and lipid-related IR in human PAH, testing the hypothesis that lipoprotein indices are more sensitive indices of IR in PAH. Read More

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https://insight.jci.org/articles/view/123611
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http://dx.doi.org/10.1172/jci.insight.123611DOI Listing
January 2019
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Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor.

Arterioscler Thromb Vasc Biol 2019 Jan 10:ATVBAHA118312280. Epub 2019 Jan 10.

From the Department of Pathophysiology, School of Basic Medicine (L.Z., R.X., X.Z., Y.Lang, F.L., Z.Y., S.L., Q.H.).

Objective- This study aims to determine whether and how the enriched metabolites of endothelial extracellular vesicles (eEVs) are critical for cigarette smoke-induced direct injury of endothelial cells and the development of pulmonary hypertension, rarely explored in contrast to long-investigated mechanisms secondary to chronic hypoxemia. Approach and Results- Metabonomic screen of eEVs from cigarette-smoking human subjects reveals prominent elevation of spermine-a polyamine metabolite with potent agonist activity for the extracellular CaSR (calcium-sensing receptor). CaSR inhibition with the negative allosteric modulator Calhex231 or CaSR knockdown attenuates cigarette smoke-induced pulmonary hypertension in rats without emphysematous changes in lungs or chronic hypoxemia. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312280DOI Listing
January 2019
2 Reads

Bendopnea: Association With Echocardiographic Features and Clinical Outcomes in Elderly Patients With Chronic Heart Failure.

Kardiologiia 2018 Dec 25;58(12):36-44. Epub 2018 Dec 25.

Pirogov Russian National Research Medical Universit.

Aim: to assess the prevalence of bendopnea and association of this symptom with clinical, laboratory and echocardiographic features, clinical outcomes during 2 years of follow-up in ambulatory elderly patients with chronic heart failure (CHF).

Materials And Methods: We conducted an open, prospective, non-randomized study of 80 ambulatory patients aged ≥60 years admitted with heart failure II-IV NYHA class CHF. Baseline survey included physical examination, estimation of Charlson comorbidity index, echocardiography and laboratory tests. Read More

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http://dx.doi.org/10.18087/cardio.2018.12.10190DOI Listing
December 2018

Risk Prediction Tools to Improve Patient Selection for Carotid Endarterectomy Among Patients With Asymptomatic Carotid Stenosis.

JAMA Surg 2019 Jan 9. Epub 2019 Jan 9.

Department of Surgery, University of Nebraska, Omaha.

Importance: Randomized clinical trials have demonstrated that patients with asymptomatic carotid stenosis are eligible for carotid endarterectomy (CEA) if the 30-day surgical complication rate is less than 3% and the patient's life expectancy is at least 5 years.

Objective: To develop a risk prediction tool to improve patient selection for CEA among patients with asymptomatic carotid stenosis.

Design, Setting, And Participants: In this cohort study, veterans 65 years and older who received both carotid imaging and CEA in the Veterans Administration between January 1, 2005, and December 31, 2009 (n = 2325) were followed up for 5 years. Read More

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http://dx.doi.org/10.1001/jamasurg.2018.5119DOI Listing
January 2019

Left Ventricular Function Before and After Aerobic Exercise Training in Women With Pulmonary Arterial Hypertension.

J Cardiopulm Rehabil Prev 2019 Jan 7. Epub 2019 Jan 7.

Department of Rehabilitation Science, George Mason University, Fairfax, Virginia (Drs Woolstenhulme, Guccione, Herrick, Collins, and Keyser); Rehabilitation Medicine Department, Clinical Research Center, National Institutes of Health, Bethesda, Maryland (Drs Woolstenhulme, Collins, Chan, and Keyser); The Department of Physical Therapy and Health Care Sciences, The George Washington University, Washington, District of Columbia (Dr Woolstenhulme); and Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia (Dr Nathan).

Background: Pulmonary arterial hypertension (PAH) is a chronic debilitating illness. The effects of vigorous aerobic exercise training (AET) on heart function in PAH are poorly understood.

Methods: Eighteen women with PAH (aged 56. Read More

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http://dx.doi.org/10.1097/HCR.0000000000000397DOI Listing
January 2019

Acute Influenza Infection Presenting with Cardiac Tamponade: A Case Report and Review of Literature.

Perm J 2019 ;23

Department of Pulmonary and Critical Care, University of Arkansas for Medical Sciences Medical Center, Little Rock.

Introduction: Cardiac complications associated with influenza infection can occur either via a direct effect of the virus on the heart or through exacerbation of preexisting cardiovascular disease. We present a case of a 57-year-old man with acute influenza infection complicated by pericardial effusion and cardiac tamponade.

Case Presentation: A 57-year-old white man presented to the Emergency Department with sudden onset of severe, nonexertional, retrosternal, pressure-like chest pain for a few hours and with fever and muscle aches for 2 days. Read More

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http://dx.doi.org/10.7812/TPP/18-104DOI Listing
January 2019

BIOMECHANICAL FORCES AND OXIDATIVE STRESS: IMPLICATIONS FOR PULMONARY VASCULAR DISEASE.

Antioxid Redox Signal 2019 Jan 9. Epub 2019 Jan 9.

University of Arizona Arizona Health Sciences Center, 12217, Medcine , 1501 N. Campbell Avenue , Tucson, Arizona, United States , 85721-0202 ;

As our fundamental understanding of the underlying causes of lung disease has increased it has become evident that oxidative stress plays a critical role. Oxidative stress in the cell is characterized by excessive generation of reactive oxygen species (ROS). Superoxide (O2-) and hydrogen peroxide (H2O2) are the main ROS involved in the regulation of cellular metabolism. Read More

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https://www.liebertpub.com/doi/10.1089/ars.2018.7720
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http://dx.doi.org/10.1089/ars.2018.7720DOI Listing
January 2019
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Prevalence, determinants, and prognostic significance of exercise-induced pulmonary hypertension in patients with hypertrophic cardiomyopathy.

Int J Cardiovasc Imaging 2019 Jan 8. Epub 2019 Jan 8.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.

Exercise-induced pulmonary hypertension (EIPH) is associated with worse outcomes in patients with heart failure or valvular heart disease. However, little is known regarding the implications of EIPH in hypertrophic cardiomyopathy (HCM) patients. We retrospectively reviewed data of consecutive HCM patients who underwent clinically indicated exercise echocardiography using a semi-supine bicycle ergometer at our hospital. Read More

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http://dx.doi.org/10.1007/s10554-018-01522-4DOI Listing
January 2019

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension.

JACC Basic Transl Sci 2018 Dec 31;3(6):744-762. Epub 2018 Dec 31.

Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.

Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension. We identified a differential role of mammalian target of rapamycin (mTOR) complex 1 and complex 2, two functionally distinct mTOR complexes, in the development of pulmonary hypertension (PH). Inhibition of mTOR complex 1 attenuated the development of PH; however, inhibition of mTOR complex 2 caused spontaneous PH, potentially due to up-regulation of platelet-derived growth factor receptors in pulmonary arterial smooth muscle cells, and compromised the therapeutic effect of the mTOR inhibitors on PH. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2452302X183023
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http://dx.doi.org/10.1016/j.jacbts.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314964PMC
December 2018
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Treatment response to indacaterol/glycopyrronium versus salmeterol/fluticasone in exacerbating COPD patients by gender: a post-hoc analysis in the FLAME study.

Respir Res 2019 Jan 8;20(1). Epub 2019 Jan 8.

Respiratory Medicine Department, University of Ioannina Medical School, Ioannina, Greece.

Background: The burden of chronic obstructive lung disease (COPD) is increasing in women, with recent evidence suggesting gender differences in disease characteristics and potentially in treatment outcomes.

Methods: FLAME was a 52-week randomized controlled trial in patients with severe-to-very-severe COPD and a history of exacerbations. In this post-hoc analysis, gender-based baseline differences and treatment outcomes between indacaterol/glycopyrronium 110/50 μg once daily (IND/GLY) and salmeterol/fluticasone 50/500 twice daily (SFC) were assessed in terms of rate of exacerbations, time-to-first exacerbation, lung function, health status, and rescue medication use. Read More

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http://dx.doi.org/10.1186/s12931-019-0972-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325763PMC
January 2019

Gasometric gradients between blood obtained from the pulmonary artery wedge and pulmonary artery positions in pulmonary arterial hypertension.

Respir Res 2019 Jan 8;20(1). Epub 2019 Jan 8.

Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue A-90, Cleveland, OH, 44195, USA.

Introduction: Little is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). We sought to determine these gradients in group 1 PAH and assess their association with disease severity and survival.

Methods: During right heart catheterization (RHC) we obtained blood from pulmonary artery (PA) and pulmonary artery wedge (PAW) positions and used co-oximetry to test their gasometric differences. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0969-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325872PMC
January 2019
1 Read