52,536 results match your criteria Cor Pulmonale


A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data†.

Eur J Cardiothorac Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany.

Objectives: Decellularized pulmonary homografts (DPH) have shown excellent results for pulmonary valve replacement. However, controlled multicentre studies are lacking to date.

Methods: Prospective European multicentre trial evaluating DPH for pulmonary valve replacement. Read More

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http://dx.doi.org/10.1093/ejcts/ezz054DOI Listing

Imaging Risk in Multisystem Inflammatory Diseases.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Second Cardiology Department, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Greece.

Rheumatic diseases are immune-mediated inflammatory multisystem diseases with frequent cardiovascular manifestations including perimyocarditis, valvular disease, coronary artery disease, heart failure with or without preserved ejection fraction, pulmonary hypertension, aneurysms, and thrombosis. Echocardiography, carotid ultrasonography, cardiac computed tomography, cardiac magnetic resonance imaging, and positron emission tomography are valid diagnostic tools for the detection of the cardiovascular complications of the multisystem diseases that frequently determine prognosis. Furthermore, the findings of these methods may offer additive risk stratification in asymptomatic patients over the conventional risk scores used to assess cardiovascular risk in the primary prevention setting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X193017
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http://dx.doi.org/10.1016/j.jcmg.2018.06.033DOI Listing
March 2019
1 Read

Mechanism, underlying substrate and predictors of atrial tachycardia following atrial fibrillation ablation using the second-generation cryoballoon.

J Cardiol 2019 Mar 13. Epub 2019 Mar 13.

University Heart Center Lübeck, Medical Clinic II (Department of Cardiology, Angiology and Intensive Care Medicine), University Hospital Schleswig-Holstein, Luebeck, Germany. Electronic address:

Background: Data regarding atrial tachycardia (AT) following second-generation cryoballoon ablation (CBA) of atrial fibrillation (AF) are limited.

Aim: To describe the incidence, mechanisms, and clinical predictors of ATs following CBA.

Methods And Results: In this retrospective single-center study 238 patients undergoing CBA for treatment of paroxysmal (91/238; 38. Read More

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http://dx.doi.org/10.1016/j.jjcc.2019.02.006DOI Listing

Impact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection.

Clin Transl Med 2019 Mar 15;8(1). Epub 2019 Mar 15.

Department of Biomedical Research, National Jewish Health, 1400 Jackson St., Room K827, Denver, CO, 80206, USA.

Background: Although cigarette smoking (CS) is by far the most important risk factor of chronic obstructive pulmonary disease (COPD), repeated and sustained infections are clearly linked to disease pathogenesis and are responsible for acute inflammatory flares (i.e. COPD exacerbations). Read More

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http://dx.doi.org/10.1186/s40169-019-0227-8DOI Listing

A smartphone oximeter with a fingertip probe for use during exercise training: usability, validity and reliability in individuals with chronic lung disease and healthy controls.

Physiotherapy 2018 Oct 26. Epub 2018 Oct 26.

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada; Department of Physical Therapy, University of British Columbia, Vancouver, Canada; Providence Health Care, St. Paul's Hospital, Vancouver, Canada. Electronic address:

Background And Aim: Telehealth is a strategy to expand the reach of pulmonary rehabilitation (PR). Smartphones can monitor and transmit oxygen saturation (SpO) and heart rate (HR) data to ensure patient safety during home-based or other exercise. The purpose of this study was to evaluate the usability, validity and reliability of a Kenek O pulse oximeter and custom prototype smartphone application (smartphone oximeter) during rest and exercise in healthy participants and those with chronic lung disease. Read More

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http://dx.doi.org/10.1016/j.physio.2018.07.015DOI Listing
October 2018

Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Pediatrics, Nationwide Childrens Hospital and Ohio State University, United States.

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http://dx.doi.org/10.1152/ajpheart.00156.2019DOI Listing

Right Ventricular and Pulmonary Vascular Changes in Pulmonary Hypertension Associated with Left Heart Disease.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Johns Hopkins Medical Institutions, United States.

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http://dx.doi.org/10.1152/ajpheart.00159.2019DOI Listing

Regulatory cytokine function in the respiratory tract.

Mucosal Immunol 2019 Mar 15. Epub 2019 Mar 15.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

The respiratory tract is an important site of immune regulation; required to allow protective immunity against pathogens, while minimizing tissue damage and avoiding aberrant inflammatory responses to inhaled allergens. Several cell types work in concert to control pulmonary immune responses and maintain tolerance in the respiratory tract, including regulatory and effector T cells, airway and interstitial macrophages, dendritic cells and the airway epithelium. The cytokines transforming growth factor β, interleukin (IL-) 10, IL-27, and IL-35 are key coordinators of immune regulation in tissues such as the lung. Read More

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http://dx.doi.org/10.1038/s41385-019-0158-0DOI Listing

Right-heart catheterization using antecubital venous access in patients with complex congenital heart defects and Glenn anastomosis.

Turk Kardiyol Dern Ars 2019 Mar;47(2):103-110

Department of Pediatric Cardiology, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey.

Objective: Right-heart catheterization using the antecubital veins has recently regained attention, and studies demonstrating the feasibility and safety of antecubital access in adults have been published. However, no changes have been observed in the preferred entrance sites in right-heart catheterizations in children with congenital heart diseases. This article is a description of the technique and features of the antecubital venous approach in pediatric patients with complex congenital heart defects and a Glenn anastomosis. Read More

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http://dx.doi.org/10.5543/tkda.2019.70558DOI Listing

Comparison of secondary prevention in coronary heart disease patients living in rural and urban areas.

Turk Kardiyol Dern Ars 2019 Mar;47(2):128-136

Department of Cardiology, Ege University Faculty of Medicine, İzmir.

Objective: The aim of the present study was to assess differences between urban and rural patients with coronary heart disease (CHD) with respect to secondary prevention.

Methods: This cross-sectional study included all consecutive patients diagnosed with CHD at 2 cardiology clinics between January 2016 and January 2017. The demographic characteristics and laboratory parameters were recorded at routine control visits. Read More

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http://dx.doi.org/10.5543/tkda.2018.68782DOI Listing

Obesity hypoventilation syndrome.

Eur Respir Rev 2019 Mar 14;28(151). Epub 2019 Mar 14.

CIBER de enfermedades respiratorias (CIBERES), Madrid, Spain.

Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity (body mass index ≥30 kg·m), daytime hypercapnia (arterial carbon dioxide tension ≥45 mmHg) and sleep disordered breathing, after ruling out other disorders that may cause alveolar hypoventilation. OHS prevalence has been estimated to be ∼0.4% of the adult population. Read More

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http://err.ersjournals.com/lookup/doi/10.1183/16000617.0097-
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http://dx.doi.org/10.1183/16000617.0097-2018DOI Listing
March 2019
1 Read

Overview of Equine Cardiac Disease.

Authors:
John D Bonagura

Vet Clin North Am Equine Pract 2019 Mar 11. Epub 2019 Mar 11.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27606, USA; Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA. Electronic address:

Equine heart diseases can be categorized with morphologic, etiologic, and physiologic diagnoses and classified anatomically as diseases of the pericardium, myocardium, valves (endocardium), and great vessels. An appreciation of normal and pathologic physiology is a key to understanding diagnosis and therapy of heart disease. Pathophysiologic diagnoses include arrhythmias, congestive heart failure, and pulmonary hypertension. Read More

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http://dx.doi.org/10.1016/j.cveq.2019.01.001DOI Listing

Acute Vasoreactivity Testing during Cardiac Catheterization of Neonates with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension.

J Pediatr 2019 Mar 11. Epub 2019 Mar 11.

Section of Cardiology, Department of Pediatrics, University of Colorado Denver School of Medicine, Denver, CO.

Objectives: To assess whether better baseline pulmonary hemodynamics or positive acute vasoreactivity testing (AVT) during cardiac catheterization are associated with improved outcomes in infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH).

Study Design: This retrospective, single-center study included 26 premature neonates with BPD who underwent catheterization to evaluate PH. AVT was assessed with exposure to 100% fractional inspired oxygen with or without inhaled nitric oxide. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.004DOI Listing

Further investigation of mitochondrial biogenesis and gene expression of key regulators in ascites- susceptible and ascites- resistant broiler research lines.

PLoS One 2019 14;14(3):e0205480. Epub 2019 Mar 14.

Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, AR, United States of America.

We have extended our previous survey of the association of mitochondrial prevalence in particular tissues with ascites susceptibility in broilers. We previously reported that in breast muscle of 22 week old susceptible line male birds had significantly higher mtDNA copy number relative to nuclear copy number (mtDNA/nucDNA), compared to resistant line male birds. The higher copy number correlated with higher expression of PPARGC1A mRNA gene. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205480PLOS

Pulmonary Insufficiency: Advantage of Pulmonary Regurgitation Volume Versus Pulmonary Regurgitation Fraction in a Congenital Heart Disease Mixed Population.

J Thorac Imaging 2019 Mar 11. Epub 2019 Mar 11.

Radiology Unit, IRCCS Policlinico San Donato.

Objective: The objective of this study was to compare the use of pulmonary regurgitation volume (PRV) or indexed PRV (PRVi) with that of pulmonary regurgitation fraction (PRF) in the assessment of patients with pulmonary regurgitation (PR) undergoing cardiac magnetic resonance (CMR) imaging.

Materials And Methods: CMR of 176 patients with PR were retrospectively evaluated. Their right ventricular diastolic (end-diastolic volume index [EDVi]) and systolic (end-systolic volume index) volume indexes, stroke volume, and ejection fraction were obtained from cine CMR sequences, whereas phase-contrast flow sequences were analyzed to obtain PRV, PRVi, and PRF. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000400DOI Listing

External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study.

COPD 2019 Mar 14:1-10. Epub 2019 Mar 14.

ak Instituto de Investigación Hospital Universitario de la Princesa (IISP), Universidad Autónoma de Madrid, Cátedra UAM-Linde , Madrid , Spain.

The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the CODEX index in a large external population of COPD patients with variable durations of follow-up. Additionally, we aimed to recalculate the thresholds of the CODEX index using the cutoffs of variables previously suggested in the 3CIA study (mCODEX). Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1484440DOI Listing
March 2019
4 Reads

Outcome of pregnancies in women with Pulmonary Hypertension: A Single Centre Experience from South India.

BJOG 2019 Mar 14. Epub 2019 Mar 14.

Anaesthesiology& Critical Care, Jawaharlal Institute of Post-graduate Medical Education & Research (JIPMER), Puducherry, India, 605006.

Objective: To study maternal complications and pregnancy outcome in women with pulmonary hypertension, attending a tertiary centre in south India.

Study Design: Retrospective Observational study.

Setting: Tertiary centre in south India. Read More

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http://dx.doi.org/10.1111/1471-0528.15681DOI Listing

Early results of ring-reinforced conduit and curved porcine patch in Sano-Norwood procedure.

J Card Surg 2019 Mar 14. Epub 2019 Mar 14.

Department of Cardiovascular Surgery, Biruni University, Istanbul, Turkey.

Background: Patch augmentation of the aortic arch as well as construction of an unobstructed pulmonary blood supply are two important surgical targets in patients with hypoplastic left heart syndrome. In this report, we aimed to present our preliminary results with a combination of two relatively new approaches in Norwood-Sano procedure.

Methods: A retrospective analysis was performed in 10 newborns with the diagnosis of hypoplastic left heart syndrome. Read More

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http://dx.doi.org/10.1111/jocs.14016DOI Listing
March 2019
1 Read

Right-Sided Subcutaneous Implantable Cardioverter Defibrillator System Implantation in a Patient with Complex Congenital Heart Disease and Dextrocardia: A Case Report and Literature Review.

Authors:
Bandar Al-Ghamdi

Case Rep Cardiol 2019 5;2019:3907190. Epub 2019 Feb 5.

Heart Centre, King Faisal Specialist Hospital and Research Centre (KFSH&RC), Riyadh, Saudi Arabia.

Patients with complex congenital heart disease (CHD) and low left ventricular ejection fraction are at an increased risk of sudden cardiac death (SCD). Prevention of SCD by subcutaneous implantable cardioverter defibrillator (S-ICD) implantation may represent a valuable option in certain CHD patients. Patients with CHD and dextrocardia pose a challenge in S-ICD system implantation, and nonstandard device placement may be required. Read More

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http://dx.doi.org/10.1155/2019/3907190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379875PMC
February 2019

Analysis of risk factors for pulmonary infection in patients with minimally invasive esophagectomy.

Oncol Lett 2019 Mar 29;17(3):3283-3288. Epub 2019 Jan 29.

Ward 1, Department of Thoracic Surgery, Sichuan Cancer Hospital and Institute, Chengdu, Sichuan 610041, P.R. China.

Clinical manifestations of patients with pulmonary infection after minimally invasive esophagectomy were analyzed. A total of 500 patients undergoing minimally invasive esophagectomy in Sichuan Cancer Hospital and Institute from January 2015 to December 2016 were consecutively selected, among which 124 patients with pulmonary infection after surgery were taken as the infection group, and the remaining 376 patients were taken as the control group. The clinical data of all patients were collected. Read More

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http://dx.doi.org/10.3892/ol.2019.9987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396272PMC

Endothelins in cardiovascular biology and therapeutics.

Nat Rev Cardiol 2019 Mar 13. Epub 2019 Mar 13.

University of Edinburgh/British Heart Foundation Centre of Research Excellence, Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh, UK.

Cardiovascular disease is a major contributor to global morbidity and mortality and is the common end point of many chronic diseases. The endothelins comprise three structurally similar peptides of 21 amino acids in length. Endothelin 1 (ET-1) and ET-2 activate two G protein-coupled receptors - endothelin receptor type A (ET) and endothelin receptor type B (ET) - with equal affinity, whereas ET-3 has a lower affinity for ET. Read More

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http://www.nature.com/articles/s41569-019-0176-3
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http://dx.doi.org/10.1038/s41569-019-0176-3DOI Listing
March 2019
1 Read

Body composition, muscle function, and physical performance in fibrotic interstitial lung disease: a prospective cohort study.

Respir Res 2019 Mar 12;20(1):56. Epub 2019 Mar 12.

Department of Medicine, University of British Columbia, Vancouver, Canada.

Background: Patients with fibrotic interstitial lung disease (ILD) are frequently physically inactive and many ILD subtypes are characterized by risk factors for myopathy; however, the importance of body composition, muscle strength, and physical performance in this population is largely unknown.

Methods: Patients were prospectively recruited from a specialized ILD clinic, baseline characteristics were collected from the clinical record, pulmonary function tests were performed per established protocols, and dyspnea was measured using the University of California San Diego Shortness of Breath Questionnaire. Dual-energy X-ray absorptiometry (DXA) was used to assess body composition; handgrip strength to determine muscle strength, and 4-m gait speed to measure physical performance. Read More

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http://dx.doi.org/10.1186/s12931-019-1019-9DOI Listing

Why Do Lung Transplant Patients Discontinue Triazole Prophylaxis?

Transpl Infect Dis 2019 Mar 13:e13067. Epub 2019 Mar 13.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic Rochester, MN, USA.

Background: Lung transplant recipients are prone to invasive fungal infections prompting many transplant centers to use prolonged triazole antifungal prophylaxis. From a practical standpoint, it is unclear if lung transplant recipients are able to continue prolonged or lifelong prophylaxis without premature discontinuation from side effects, drug interactions, development of fungal disease, or medication cost. We examined the number of patients that are able to reach a prophylactic endpoint and understand the reasons for early termination. Read More

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http://dx.doi.org/10.1111/tid.13067DOI Listing

Indwelling pleural catheters for benign pleural effusions: what is the evidence?

Curr Opin Pulm Med 2019 Mar 6. Epub 2019 Mar 6.

Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, USA.

Purpose Of Review: Benign pleural effusions are common and usually managed by treating the underlying disease process. In some patients, these effusions may be refractory to medical management. Indwelling pleural catheters, used extensively for malignant pleural effusions, are increasingly used in benign pleural effusions not responding to medical therapy. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000574DOI Listing

An update on the association of protein kinases with cardiovascular diseases.

Curr Pharm Des 2019 Mar 11. Epub 2019 Mar 11.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh (U.P.). India.

Background: Protein kinases are the enzymes involved in phosphorylation of different proteins and leads to functional changes in those proteins. They are classified into the AGC (Protein kinase A/ Protein kinase G/ Protein kinase C) families of protein and Rho-associated kinase protein (ROCK) and belong to serine-threonine kinases family. The AGC family of kinases are involved in G-protein stimuli, muscle contraction, platelet biology and lipid signaling. Read More

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http://dx.doi.org/10.2174/1381612825666190312115140DOI Listing

Idiopathic Pulmonary Fibrosis: New and Emerging Treatment Options.

Drugs Aging 2019 Mar 12. Epub 2019 Mar 12.

National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, London, SW7 2AZ, UK.

Idiopathic pulmonary fibrosis (IPF) is a progressive and debilitating, scarring lung disease with a worse prognosis than some cancers. The incidence of IPF is increasing and while current antifibrotic therapies slow disease progression, they do not offer a cure. The pathobiology of IPF is complex and is driven by aging-associated cellular dysfunction, epithelial injury, and an aberrant wound-healing response characterised by fibroblast activation and extracellular matrix accumulation (ECM) in the interstitium. Read More

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http://dx.doi.org/10.1007/s40266-019-00647-yDOI Listing

Significant functional mitral regurgitation affects left atrial function in heart failure patients: haemodynamic correlations and prognostic implications.

Eur Heart J Cardiovasc Imaging 2019 Mar 12. Epub 2019 Mar 12.

Department of Cardiology, AORN Ospedali dei Colli-Monaldi, Naples, Italy.

Aims: Functional mitral regurgitation (FMR) is a well-known pathophysiological factor in heart failure (HF) patients, and left atrial function (LAF) is a novel determinant of clinical status and outcome in this setting. However, little is known about the pathophysiological role of FMR on LAF in HFrEF patients. Aim of this study is to explore the possible interplay between the severity of FMR and LAF in heart failure with reduce ejection fraction (HFrEF) patients and their possible consequences. Read More

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http://dx.doi.org/10.1093/ehjci/jez036DOI Listing
March 2019
3.669 Impact Factor

Pathological Implications of Receptor for Advanced Glycation End-Product () Gene Polymorphism.

Dis Markers 2019 4;2019:2067353. Epub 2019 Feb 4.

CHU Clermont-Ferrand, Department of Medical Biochemistry and Molecular Biology, 63000 Clermont-Ferrand, France.

The receptor for advanced glycation end-products (RAGE) is a cell surface transmembrane multiligand receptor, encoded by the gene. RAGE presents many transcripts, is expressed mainly in the lung, and involves multiple pathways (such as NFB, Akt, p38, and MAP kinases) that initiate and perpetuate an unfavorable proinflammatory state. Due to these numerous functional activities, RAGE is implicated in multiple diseases. Read More

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https://www.hindawi.com/journals/dm/2019/2067353/
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http://dx.doi.org/10.1155/2019/2067353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378764PMC
February 2019
1 Read

Computational Fluid Dynamics Characterization of Two Patient-Specific Systemic-to-Pulmonary Shunts before and after Operation.

Comput Math Methods Med 2019 3;2019:1502318. Epub 2019 Feb 3.

Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China.

Studying the haemodynamics of the central shunt (CS) and modified Blalock-Taussig shunt (MBTS) benefits the improvement of postoperative recovery for patients with an aorta-pulmonary shunt. Shunt configurations, including CS and MBTS, are virtually reconstructed for infants A and B based on preoperative CT data, and three-dimensional models of A, 11 months after CS, and B, 8 months after MBTS, are reconstructed based on postoperative CT data. A series of parameters including energy loss, wall shear stress, and shunt ratio are computed from simulation to analyse the haemodynamics of CS and MBTS. Read More

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http://dx.doi.org/10.1155/2019/1502318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378018PMC
February 2019

Prolonged mechanical ventilation after left ventricular assist device implantation: risk factors and clinical implications.

ESC Heart Fail 2019 Mar 12. Epub 2019 Mar 12.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, Hufelandstr. 55, Essen, 45147, Germany.

Aims: Unsuccessful weaning from ventilator after major cardiovascular procedures has been shown to be associated with increased post-operative morbidity and mortality. Our study aimed to identify predictors and clinical implications of prolonged mechanical ventilation (PMV) after left ventricular assist device (LVAD) implantation.

Methods And Results: We analysed the data of patients receiving a continuous-flow LVAD in our centre from December 2010 to September 2017. Read More

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http://dx.doi.org/10.1002/ehf2.12428DOI Listing

Clinicopathologic findings of naturally occurring Rabbit Hemorrhagic Disease Virus 2 infection in pet rabbits.

Vet Clin Pathol 2019 Mar 12. Epub 2019 Mar 12.

Centro Veterinario Los Sauces, Madrid, Spain.

Two pet rabbits were presented with an acute decrease in appetite and activity. Rabbit 1 showed severe hypothermia, bradycardia, arrhythmias, a heart murmur, dyspnea, occlusion of the nares with secretions, icterus, dehydration, and gaseous gastrointestinal dilation. The urine was dark yellow. Read More

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http://doi.wiley.com/10.1111/vcp.12701
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http://dx.doi.org/10.1111/vcp.12701DOI Listing
March 2019
1 Read

Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy.

Redox Biol 2019 Mar 6;22:101161. Epub 2019 Mar 6.

Cardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) failure even with optimal medical care. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101161DOI Listing

Quantitative and semi-quantitative computed tomography analysis of interstitial lung disease associated with systemic sclerosis: A longitudinal evaluation of pulmonary parenchyma and vessels.

PLoS One 2019 12;14(3):e0213444. Epub 2019 Mar 12.

Institute of Radiology, Pole of Imaging, Laboratory and Infectivology Sciences, Diagnostic Imaging Area, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.

Objectives: To evaluate interstitial lung disease associated with systemic sclerosis (SSc-ILD) and its changes during treatment by using quantitative analysis (QA) compared to semi-quantitative analysis (semiQA) of chest computed tomography (CT) scans. To assess the prognostic value of QA in predicting functional changes.

Materials And Methods: We retrospectively selected 35 consecutive patients with SSc-ILD with complete pulmonary functional evaluation, Doppler-echocardiography, immunological tests, and chest CT scan at both baseline and follow-up after immunosuppressive therapy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213444PLOS

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases.

Am J Respir Crit Care Med 2019 Mar 12. Epub 2019 Mar 12.

Imperial Col. at the Nat. Hrt. & Lung In, London, United Kingdom of Great Britain and Northern Ireland.

Cellular senescence is now considered an important driving mechanism for chronic lung diseases, particularly COPD and idiopathic pulmonary fibrosis. Cellular senescence is due to replicative and stress-related senescence with activation of p53 and p16INK4a respectively, leading to activation of p21CIP1 and cell cycle arrest. Senescent cells secrete multiple inflammatory proteins known as the senescence-associated secretory phenotype (SASP), leading to low grade chronic inflammation, which further drives senescence. Read More

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http://dx.doi.org/10.1164/rccm.201810-1975TRDOI Listing

Natriuretic Peptides in Clinical Practice.

Anatol J Cardiol 2019 Mar;21(Suppl 1):1-40

Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir-Turkey.

Natriuretic peptides have long been introduced into clinical practice. These biomarkers have certainly been shown to provide useful information in the diagnosis, prognosis and risk stratification in heart failure and also may have a role in the guidance of heart failure therapy. Although, there are some limitations in using of these markers such as lack of specificity, aging, renal dysfunction or obesity, among the huge number of candidates for heart failure biomarkers, only natriuretic peptides are currently widely used in daily clinical practice in heart failure. Read More

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http://dx.doi.org/10.14744/AnatolJCardiol.2019.55623DOI Listing
March 2019
1 Read

Mortality from heart diseases following occupational radiation exposure: analysis of the National Registry for Radiation Workers (NRRW) in the United Kingdom.

J Radiol Prot 2019 Mar 12;39(2):327-353. Epub 2019 Mar 12.

Statistically significant increases in heart disease (HD) mortality with cumulative recorded occupational radiation dose from external sources were observed among 174 541 subjects, who were predominately exposed to protracted low doses over a number of years, and were followed up until the end of 2011 in the UK National Registry for Radiation Workers (NRRW) cohort. Amongst the subtypes of HD, the increasing trends with cumulative dose arose for ischaemic heart disease (IHD) and other HD (which includes pulmonary HD, valve disorders, cardiomyopathy, cardiac dysrhythmias, carditis, conduction disorder and ill-defined HD). For IHD, the increased mortality appears to be at least 20 years after first exposure and the excess risk peaked between 30 and 40 years after the first exposure. Read More

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http://dx.doi.org/10.1088/1361-6498/ab02b2DOI Listing
March 2019
1.702 Impact Factor

Multimodality imaging in ischaemic heart failure.

Lancet 2019 Mar;393(10175):1056-1070

Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.

In heart failure, extensive evaluation with modern non-invasive imaging modalities is needed to assess causes, pathophysiology, and haemodynamics, to determine prognosis and consider therapeutic options. This systematic evaluation includes a stepwise assessment of left ventricular size and function, the presence and severity of coronary artery disease, mitral regurgitation, pulmonary hypertension, right ventricular dilation and dysfunction, and tricuspid regurgitation. Based on this imaging-derived information, the need for specific therapies besides optimised medical therapy can be determined. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)33207-0DOI Listing
March 2019
1 Read

The Economic Effect of Early Management in Patients with Early Chronic Obstructive Pulmonary Disease: Results from a Population-Based Nationwide Survey.

Lung 2019 Mar 11. Epub 2019 Mar 11.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, 05029, Seoul, Republic of Korea.

Purpose: The economic effect of regular follow-up and early management in patients with early chronic obstructive pulmonary disease (COPD) has not yet been clarified. Therefore, this study aimed to estimate the economic effect of regular follow-up and early management in these patients.

Methods: Patients with early COPD were identified from the Korea National Health and Nutrition Examination Survey. Read More

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http://dx.doi.org/10.1007/s00408-019-00208-5DOI Listing
March 2019
2.171 Impact Factor

Clinical Features and Outcomes of Patients with Sarcoidosis-associated Pulmonary Hypertension.

Sci Rep 2019 Mar 11;9(1):4061. Epub 2019 Mar 11.

Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.

The presence of pulmonary hypertension (PH) significantly worsens outcomes in patients with advanced sarcoidosis, but its optimal management is unknown. We aimed to characterize a large sarcoidosis-associated pulmonary hypertension (SAPH) cohort to better understand patient characteristics, clinical outcomes, and management strategies including treatment with PH therapies. Patients at Duke University Medical Center with biopsy-proven sarcoidosis and SAPH confirmed by right heart catheterization (RHC) were identified from 1990-2010. Read More

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http://www.nature.com/articles/s41598-019-40030-w
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http://dx.doi.org/10.1038/s41598-019-40030-wDOI Listing
March 2019
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Impaired pulmonary function and its association with clinical outcomes, exercise capacity and quality of life in children with congenital heart disease.

Int J Cardiol 2019 Mar 1. Epub 2019 Mar 1.

Paediatric and Congenital Cardiology Department, M3C Regional Reference Centre, Montpellier University Hospital, Montpellier, France; Center for Studies and Research on Health Services and Quality of Life, Aix-Marseille University, Marseille, France; PhyMedExp, University of Montpellier, INSERM, CNRS, France. Electronic address:

Background: Impaired pulmonary function is an independent predictor of mortality in adult congenital heart disease (CHD), but has been scarcely studied in the paediatric CHD population.

Aims: To compare the pulmonary function of children with CHD to healthy controls, and evaluate its association with clinical outcomes, exercise capacity, and quality of life.

Methods: Cross-sectional multicentre study among 834 children (555 CHD and 279 control subjects) who underwent a complete spirometry and a cardiopulmonary exercise test (CPET). Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.069DOI Listing

Occurrence of a primary liver cancer with an unusual histologic appearance as a late Fontan complication.

Pathol Res Pract 2019 Feb 27. Epub 2019 Feb 27.

Department of Pathology, National Cerebral and Cardiovascular Center, Suita, 5658565, Japan.

The Fontan procedure is an open heart procedure performed in pediatric patients with a particular congenital cardiac anomaly known as a univentricular heart. The procedure is used to reroute the systemic venous blood from the inferior vena cava directly to the pulmonary artery. It improves patients' prognoses, but various late-phase extracardiac complications that manifest when patients reach adolescence have been recognized. Read More

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http://dx.doi.org/10.1016/j.prp.2019.02.016DOI Listing
February 2019

Management of Congenital Heart Disease: State of the Art; Part I-ACYANOTIC Heart Defects.

Children (Basel) 2019 Mar 8;6(3). Epub 2019 Mar 8.

McGovern Medical School, University of Texas-Houston, Children's Memorial Hermann Hospital, Houston, TX 77030, USA.

Since the description of surgery for patent ductus arteriosus in late 1930s, an innumerable number of advances have taken place in the management of congenital heart defects (CHDs). In this review the current status of treatment of seven of the most common acyanotic CHDs was reviewed. The discussion included indications for, and timing of, intervention and methods of intervention. Read More

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https://www.mdpi.com/2227-9067/6/3/42
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http://dx.doi.org/10.3390/children6030042DOI Listing
March 2019
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The effects of pulmonary valve replacement on QRS duration in repaired tetralogy of Fallot patients with pulmonary regurgitation.

J Electrocardiol 2019 Feb 27;54:36-39. Epub 2019 Feb 27.

Ahmanson/UCLA Adult Congenital Heart Disease Center, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America. Electronic address:

Introduction: Chronic pulmonary regurgitation (PR) following surgical correction in Tetralogy of Fallot (TOF) leads to right ventricular (RV) dysfunction, arrhythmias and sudden cardiac death (SCD). Pulmonary valve replacement (PVR) decreases PR and improves RV function, but data regarding QRS duration reduction remain scarce.

Methods: All adult TOF patients undergoing transcatheter PVR or surgical PVR from 2010 to 2016 were included. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2019.02.010DOI Listing
February 2019

Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China.

Environ Pollut 2019 Mar 2;248:874-887. Epub 2019 Mar 2.

Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

The development of a rodent ambient particulate matter (PM) inhalation system is critical for drawing causal inferences between PM exposure and the onset of human diseases. In this study, we constructed a real-ambient PM exposure system to investigate multi-organ injury and the reversibility of the impairments in C57BL/6 J male mice exposed to PM with a duration of up to three months in Shijiazhuang, a city with the highest PM2.5 concentration in China. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.097DOI Listing

[Thoracoscopic clipping of patent ductus arteriosus: position of surgery in the era of transcatheter procedures].

Khirurgiia (Mosk) 2019 (2):5-12

Meshalkin National Medical Research Center of Healthcare Ministry of the Russian Federation, Novosibirsk, Russia.

Aim: To describe single-center evolution of the procedure and to evaluate the results of thoracoscopic clipping of patent ductus arteriosus (PDA) with diameter over 3,0 mm in term infants weighting over 4,0 kg.

Material And Methods: Thoracoscopic clipping of PDA has been performed in 140 patients for the period from March 2012 to March 2018 in Meshalkin National Medical Research Center. Mean age was 4. Read More

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http://dx.doi.org/10.17116/hirurgia20190215DOI Listing
January 2019

Preoperative balloon pulmonary angioplasty enabled noncardiac surgery of a patient with chronic thromboembolic pulmonary hypertension (CTEPH): A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14807

Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo.

Rationale: Chronic thromboembolic pulmonary hypertension (CTEPH) is a disease with a poor prognosis, characterized by chronic thromboembolic obstruction of the pulmonary arteries and pulmonary hypertension. Balloon pulmonary angioplasty (BPA) is a newly emergent treatment for CTEPH, which may substitute pulmonary endarterectomy, the standard but more invasive treatment for CTEPH. Here, we report the case of a CTEPH patient who underwent 2 noncardiac surgeries without complications after preoperative intervention of BPA. Read More

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http://Insights.ovid.com/crossref?an=00005792-201903080-0006
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http://dx.doi.org/10.1097/MD.0000000000014807DOI Listing
March 2019
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Awake and fully mobile patients on cardiac extracorporeal life support.

Ann Cardiothorac Surg 2019 Jan;8(1):44-53

Division of Pulmonary, Allergy, and Critical Care, NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, USA.

Early mobilization of critically ill patients is increasingly being recognized as not only safe and feasible, but also as a potential means of optimizing outcomes in the intensive care unit (ICU). With the rapidly expanding use of extracorporeal life support (ECLS) for severe cardiopulmonary failure, there is a growing interest in the application of early mobilization to this patient population, which has been shown to be safe and feasible in select patient populations. However, some patients receiving ECLS support may benefit more than others. Read More

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http://dx.doi.org/10.21037/acs.2018.08.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379193PMC
January 2019

Inspiratory muscle training improves autonomic modulation and exercise tolerance in chronic obstructive pulmonary disease subjects: A randomized-controlled trial.

Respir Physiol Neurobiol 2019 Mar 7;263:31-37. Epub 2019 Mar 7.

Laboratory of Cardiovascular Adaptations to Exercise - LACORE, Universidade Federal do Maranhão, São Luís, Brazil; Programa de Pós-Graduação em Saúde do Adulto - PPGSAD, Universidade Federal do Maranhão, São Luís, Brazil; Cardiopulmonary Rehabilitation Center, Universidade Federal do Maranhão University Hospital 'Presidente Dutra', São Luís, Brazil; Programa de Doutorado da Rede Nordeste de Biotecnologia - RENORBIO, Brazil; Programa de Pós Graduação em Educação Física, Universidade Federal do Maranhão, São Luís, Brazil. Electronic address:

Objectives: We aimed to evaluate the effect a regular inspiratory muscle training program on autonomic modulation measured by heart rate variability, exercise capacity and respiratory function in chronic obstructive pulmonary disease subjects (COPD).

Design: Single-center controlled study, with balanced randomization (1:1 for two arms).

Setting: A COPD reference hospital localized in Sao Luís, Brazil. Read More

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http://dx.doi.org/10.1016/j.resp.2019.03.003DOI Listing
March 2019
1.971 Impact Factor

Amiodarone for prevention of atrial fibrillation following esophagectomy.

J Thorac Cardiovasc Surg 2019 Feb 5. Epub 2019 Feb 5.

Department of Surgery, School of Medicine, Indiana University, Indianapolis, Ind.

Objectives: Atrial fibrillation (AF) is a common complication after esophagectomy and is associated with symptoms, hemodynamic instability, prolonged hospital stay, and an increased incidence of mortality. Our objective was to determine the efficacy and safety of intravenous amiodarone for prophylaxis of postesophagectomy AF.

Methods: In this retrospective cohort study, 309 patients who underwent esophagectomy formed the initial cohort. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.01.095DOI Listing
February 2019