56,545 results match your criteria Cor Pulmonale


Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study.

Eur Heart J 2020 Jun 4. Epub 2020 Jun 4.

Department of Cardiology, Xijing Hospital, Changle West Road, Xi'an, 710032, China.

Aims: It remains unknown whether the treatment of hypertension influences the mortality of patients diagnosed with coronavirus disease 2019 (COVID-19).

Methods And Results: This is a retrospective observational study of all patients admitted with COVID-19 to Huo Shen Shan Hospital. The hospital was dedicated solely to the treatment of COVID-19 in Wuhan, China. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa433DOI Listing

Development and Validation of the Chronic Disease Population Risk Tool (CDPoRT) to Predict Incidence of Adult Chronic Disease.

JAMA Netw Open 2020 Jun 1;3(6):e204669. Epub 2020 Jun 1.

Dalla Lana School of Public Health, Division of Epidemiology, University of Toronto, Toronto, Ontario, Canada.

Importance: Predicting chronic disease incidence for the population provides a comprehensive picture to health policy makers of their jurisdictions' overall future chronic disease burden. However, no population-based risk algorithm exists for estimating the risk of first major chronic disease.

Objective: To develop and validate the Chronic Disease Population Risk Tool (CDPoRT), a population risk algorithm that predicts the 10-year incidence of the first major chronic disease in the adult population. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.4669DOI Listing

Reference Values for Chronotropic Index from 1280 Incremental Cycle Ergometry Tests.

Med Sci Sports Exerc 2020 Jun 1. Epub 2020 Jun 1.

Exercise Physiology Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA.

Purpose: Clinical cardiopulmonary exercise testing can determine causes of exercise limitation. The slope of heart rate (fc) versus oxygen uptake (V˙O2), which we call the chronotropic index (CI), can help identify cardiovascular impairment. We aimed to develop a reference equation for CI based on a large number of subjects considered to have normal exercise responses. Read More

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http://dx.doi.org/10.1249/MSS.0000000000002417DOI Listing

Definition of pulmonary embolism-related death and classification of the cause of death in venous thromboembolism studies: Communication from the SSC of the ISTH.

J Thromb Haemost 2020 Jun;18(6):1495-1500

Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.

Pulmonary embolism (PE)-related death is often a component of the primary outcome in venous thromboembolism (VTE) clinical studies. Definitions for PE-related death vary widely, which may lead to biased risk estimates of clinical outcomes, thereby affecting both internal and external validity of study results. We here provide a standardized definition of PE-related death and propose guidance for classification and reporting of the cause of death for clinical studies in VTE. Read More

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http://dx.doi.org/10.1111/jth.14769DOI Listing

Clinical predictors of all-cause mortality in patients presenting to specialist heart failure clinic with raised NT-proBNP and no heart failure.

ESC Heart Fail 2020 Jun 4. Epub 2020 Jun 4.

Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.

Aims: Clinical outcomes for patients suspected of having heart failure (HF) who do not meet the diagnostic criteria of any type of HF by echocardiography remain unknown. The aim of this study was to investigate the clinical predictors of all-cause mortality in patients with suspected HF, a raised N-terminal pro-b-type natriuretic peptide (NTproBNP) and who do not meet the diagnostic criteria of any type of HF by echocardiography.

Methods And Results: Relevant data were taken from the Sheffield HEArt Failure (SHEAF) registry (222349P4). Read More

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http://dx.doi.org/10.1002/ehf2.12742DOI Listing

Renal artery intervention for a patient with flash pulmonary edema accompanied by elevation of troponin levels due to bilateral renal artery stenosis and multivessel coronary disease: a case report.

J Int Med Res 2020 Jun;48(6):300060520926032

Department of Cardiology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong, China.

An 84-year-old woman complaining of acute-onset chest distress for 2 hours was referred to the Department of Cardiology, Guangzhou Red Cross Hospital, China. A physical examination showed signs of acute pulmonary edema with considerably elevated blood pressure of 186/120 mmHg. An electrocardiogram showed ST segment depression in leads I, II, and III, and from V4 to V6. Read More

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http://dx.doi.org/10.1177/0300060520926032DOI Listing

Effect of Treprostinil on the Early Postoperative Prognosis of Patients with Severe Left Heart Valvular Disease Combined with Severe Pulmonary Hypertension.

Ann Thorac Cardiovasc Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Cardiac Surgery, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objective: To investigate the effect of treprostinil on the early postoperative prognosis of patients with severe left heart valvular disease combined with severe pulmonary hypertension (PAH).

Methods: A retrospective study including 55 patients with severe left heart valvular disease combined with severe PAH who underwent left heart valve replacement in our hospital between January 2019 and May 2019 was conducted. Patients were divided into two groups (treprostinil group and control group), and the clinical data of patients in the two groups were compared and analyzed. Read More

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http://dx.doi.org/10.5761/atcs.oa.20-00003DOI Listing

Alveolar lipids in pulmonary disease. A review.

Lipids Health Dis 2020 Jun 3;19(1):122. Epub 2020 Jun 3.

Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA.

Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is composed by multiple cell types with specialized functions and coordinately acting to meet specific physiologic requirements. The alveoli are the niche of the most active lipid metabolic cell in the lung, the type 2 cell (T2C). Read More

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http://dx.doi.org/10.1186/s12944-020-01278-8DOI Listing

Identification of Differentially Expressed Genes Associated with Idiopathic Pulmonary Arterial Hypertension by Integrated Bioinformatics Approaches.

J Comput Biol 2020 Jun 3. Epub 2020 Jun 3.

Department of Structural Heart Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

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http://dx.doi.org/10.1089/cmb.2019.0433DOI Listing

Predictors of patient-reported outcomes at discharge in patients with heart failure.

Eur J Cardiovasc Nurs 2020 Jun 3:1474515120902390. Epub 2020 Jun 3.

Department of Cardiology, Aarhus University Hospital, Denmark.

Background: It is well-established that heart failure has a negative impact on quality of life. However, little is known about patient-related predictors of health-related quality of life, anxiety and depression, symptoms and illness perception among patients with heart failure.

Aim: To study the association between patient-related predictors and patient-reported outcome measures at discharge from hospital in a cohort of patients with heart failure. Read More

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http://dx.doi.org/10.1177/1474515120902390DOI Listing

Necroptosis inhibition prevents long-term cardiac damage during pneumococcal pneumonia and invasive disease.

J Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

Department of Microbiology, The University of Alabama at Birmingham, Birmingham, USA.

Background: Streptococcus pneumoniae (Spn) infection can result in bacteremia with devastating consequences including heart damage. Necroptosis is a pro-inflammatory form of cell death instigated by pore-forming toxins such as Spn pneumolysin. Necroptosis-inhibiting drugs may lessen organ damage during invasive pneumococcal disease (IPD). Read More

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http://dx.doi.org/10.1093/infdis/jiaa295DOI Listing

Heightened Dependence of Left-Heart Filling Pressures on Right-Heart Failure in Congenital Heart Disease.

Can J Cardiol 2020 Feb 26. Epub 2020 Feb 26.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Background: Pulmonary artery wedge pressure (PAWP) is often elevated in patients with right-sided congenital heart disease (CHD), raising the possibility of coexisting left-heart disease, but pressure-volume relationships in the left and right sides of the heart influence one another through interdependence, which may be amplified in patients with CHD.

Methods: We hypothesized that increases in PAWP in patients with CHD would be more strongly related to ventricular interdependence compared with patients who have isolated left-heart disease such as heart failure with preserved ejection fraction (HFpEF). Ventricular interdependence was assessed by the relationship between PAWP and right-atrial pressure (RAP), RAP/PAWP ratio, and the left-ventricular (LV) eccentricity index. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.02.084DOI Listing
February 2020

Rationale and Design of ORCHID: A Randomized Placebo-Controlled Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19.

Ann Am Thorac Soc 2020 Jun 3. Epub 2020 Jun 3.

Vanderbilt University Medical Center, 12328, Emergency Medicine, Nashville, Tennessee, United States.

The Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease (ORCHID) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with COVID-19. This document provides the rationale and background for the trial and highlights key design features. We discuss five novel challenges to the design and conduct of a large, multi-center, randomized trial during a pandemic, including: 1) widespread, off-label use of the study drug before the availability of safety and efficacy data; 2) the need to adapt traditional procedures for documentation of informed consent during an infectious pandemic; 3) developing a flexible and robust Bayesian analysis incorporating significant uncertainty about the disease, outcomes, and treatment; 4) obtaining indistinguishable drug and placebo without delaying enrollment; and 5) rapidly obtaining administrative and regulatory approvals. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202005-478SDDOI Listing

Potential Neuroinvasive Pathways of SARS-CoV-2: Deciphering the Spectrum of Neurological Deficit Seen in Coronavirus Disease 2019 (COVID-19).

J Med Virol 2020 Jun 3. Epub 2020 Jun 3.

Mount Auburn Hospital, Boston Urogynecology Associates, Cambridge, MA, USA.

COVID-19 was declared a global pandemic on March 11, 2020. Scientists and clinicians must acknowledge that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has the potential to attack the human body in multiple ways simultaneously and exploit any weaknesses of its host. A multipronged attack could potentially explain the severity and extensive variety of signs and symptoms observed in patients with COVID-19. Read More

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http://dx.doi.org/10.1002/jmv.26105DOI Listing

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial.

JAMA 2020 Jun 3. Epub 2020 Jun 3.

Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.

Importance: Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed.

Objective: To evaluate the efficacy and adverse effects of convalescent plasma therapy for patients with COVID-19.

Design, Setting, And Participants: Open-label, multicenter, randomized clinical trial performed in 7 medical centers in Wuhan, China, from February 14, 2020, to April 1, 2020, with final follow-up April 28, 2020. Read More

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http://dx.doi.org/10.1001/jama.2020.10044DOI Listing

Understanding the age divide in COVID-19: Why are children overwhelmingly spared?

Am J Physiol Lung Cell Mol Physiol 2020 Jun 3. Epub 2020 Jun 3.

Pediatric Surgery, University of Texas McGovern Medical School, United States.

The rapid emergence and subsequent global dissemination of SARS-CoV-2 Disease (COVID-19) has resulted in over 4 million cases worldwide. The disease has a marked predilection for adults, and children are relatively spared. Understanding the age-based differences in pathophysiological pathways and processes relevant to the onset and progression of disease both in the clinical course and in experimental disease models may hold the key to the identification of therapeutic targets. Read More

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http://dx.doi.org/10.1152/ajplung.00183.2020DOI Listing

Serum apolipoprotein A-I concentration differs in coronary and peripheral artery disease.

Scand J Clin Lab Invest 2020 Jun 3:1-5. Epub 2020 Jun 3.

Center for Vascular Surgery and Interventional Radiology, Tampere University Hospital, Tampere, Finland.

Coronary artery and peripheral artery diseases represent different clinical outcomes of atherosclerosis and despite sharing common risk factors the ultimate reasons determining disease presentation are still unclear. The present study sought to define and compare the serum lipid and apolipoprotein profiles of patients undergoing coronary artery bypass grafting and those treated invasively for symptomatic lower extremity peripheral artery disease. Altogether 218 coronary and 280 peripheral artery disease patients treated between 2013 and 2014 in the Tampere University Hospital, Tampere, Finland, with available lipid measurements within two years prior to the intervention were retrospectively analysed. Read More

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http://dx.doi.org/10.1080/00365513.2020.1746974DOI Listing

Post-Left Atrium Space Index in Fetuses With Total Anomalous Pulmonary Venous Connection and Other Congenital Heart Diseases.

J Ultrasound Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing Key Laboratory of Maternal-Fetal Medicine in Fetal Heart Disease, Beijing, China.

Objectives: We aimed to explore the value of the post-left atrium space (PLAS) index in the diagnosis of total anomalous pulmonary venous connection (TAPVC) and the effect of other congenital heart diseases on the PLAS index in the fetus.

Methods: The PLAS index of 69 fetuses with TAPVC was analyzed retrospectively. Approximately 252 healthy fetuses were randomly selected as controls, and 110 cases of intracardiac malformations were randomly selected for comparison. Read More

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http://dx.doi.org/10.1002/jum.15362DOI Listing

Paradoxical low-flow phenotype in hospitalized heart failure with preserved ejection fraction.

Int J Cardiol Heart Vasc 2020 Jun 28;28:100539. Epub 2020 May 28.

Cardiology Unit and LTTA Centre, University of Ferrara, Italy.

Background: Low flow (LF) in heart failure with preserved ejection fraction (HFpEF) is a paradox but is associated with worse prognosis. Determinants of LF in HFpEF have not been clarified but their assessment could corroborate recognition and definition of such a paradoxical condition.

Methods: A cohort of 193 patients hospitalized with HFpEF was retrospectively studied and divided in a group with LF (N = 45), defined by a left ventricular (LV) stroke volume index (SVI) < 30 ml/m, and a group with normal flow (N = 148). Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262439PMC

Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups.

Int J Cardiol Heart Vasc 2020 Jun 29;28:100538. Epub 2020 May 29.

Departments of Medicine, University of Illinois at Chicago, USA.

Background: Although traditional risk factors for atrial fibrillation (AF) and its outcomes are established in whites, their role in the pathogenesis of AF across race-ethnicity and both sexes remain unclear. Cohort studies have consistently shown worse AF-related outcomes in these groups. The objective of this study was to determine the role played by race- and sex-specific risk factors in AF outcomes in non-Hispanic blacks (NHBs), Hispanics/Latinos (H/Ls), and non-Hispanic whites (NHWs). Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262442PMC

Ceftolozane/tazobactam for pulmonary exacerbation in a 63-year-old cystic fibrosis patient with renal insufficiency and an elevated MIC to .

IDCases 2020 18;21:e00830. Epub 2020 May 18.

Adult Cystic Fibrosis Center, Pensacola Lung Group, Pensacola, FL, United States.

Cystic fibrosis (CF) is a progressive genetic disorder caused by mutations in a gene encoding the cystic fibrosis transmembrane regulator (CFTR) protein leading to persistent and difficult to treat lower airway infections. Multi-drug resistant is becoming increasingly more common as a cause of pulmonary exacerbations, and newer agents such as ceftolozane/tazobactam (C/T) are being sought for treatment. There is currently little published data regarding its use in cystic fibrosis, particularly in the setting of reduced renal clearance. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256659PMC

Self-Reported Prevalence of Chronic Non-Communicable Diseases in Relation to Socioeconomic and Educational Factors in Colombia: A Community-Based Study in 11 Departments.

Glob Heart 2020 Apr 21;15(1):35. Epub 2020 Apr 21.

Fundación Oftalmológica de Santander-FOSCAL, Floridablanca, CO.

Background: Chronic non-communicable diseases are prevalent conditions in developing countries, such as Colombia. Several socioeconomic and educational factors have been associated with these pathologies. However, there is little country-specific information regarding the self-reported prevalence of chronic diseases and their association with the aforementioned factors in Colombia. Read More

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http://dx.doi.org/10.5334/gh.792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218792PMC

High Burden of Cardiac Disease in Pregnancy at a National Referral Hospital in Western Kenya.

Glob Heart 2020 Feb 7;15(1):10. Epub 2020 Feb 7.

Directorate of Reproductive Health, Moi Teaching and Referral Hospital, Eldoret, KE.

Background: Cardiac disease is a leading cause of non-obstetric maternal death worldwide, but little is known about its burden in sub-Saharan Africa.

Objectives And Methods: We conducted a retrospective case-control study of pregnant women admitted to a national referral hospital in western Kenya between 2011-2016. Its purpose was to define the burden and spectrum of cardiac disease in pregnancy and assess the utility of the CARPREG I and modified WHO (mWHO) clinical risk prediction tools in this population. Read More

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http://dx.doi.org/10.5334/gh.404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218778PMC
February 2020

Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease.

Pulm Circ 2020 Apr-Jun;10(2):2045894020922118. Epub 2020 May 14.

Department of Pediatrics, University of California, San Francisco, CA, USA.

The risk and progression of pulmonary vascular disease in patients with congenital heart disease is dependent on the hemodynamics associated with different lesions. However, the underlying mechanisms are not understood. Endothelin-1 is a potent vasoconstrictor that plays a key role in the pathology of pulmonary vascular disease. Read More

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http://dx.doi.org/10.1177/2045894020922118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238833PMC

The ventilatory abnormalities and prognostic values of H FPEF score in dyspnoeic patients with preserved left ventricle systolic function.

ESC Heart Fail 2020 Jun 3. Epub 2020 Jun 3.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Aims: Heart failure with preserved ejection fraction (HFpEF) is one of the major diagnoses in dyspnoeic subjects, and H FPEF score enables robust differentiation of HFpEF. Given ventilatory abnormalities prevail in subjects with HFpEF, the associations between H FPEF score and pulmonary function remain to be elucidated.

Methods And Results: Subjects who presented with exertional dyspnoea and had left ventricular ejection fraction of >50% were eligible for this study. Read More

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http://dx.doi.org/10.1002/ehf2.12754DOI Listing

Added Value of Live 3-Dimensional Transesophageal Echocardiography During Procedures in Fontan Patients.

Pediatr Cardiol 2020 Jun 1. Epub 2020 Jun 1.

Department of Pediatric Cardiology, Advocate Children's Hospital, Chicago, IL, USA.

3D transesophageal echocardiography (3D-TEE) has proven useful and accurate during some operating room (OR), interventional cardiac catheterization (Cath), and electrophysiologic (EP) procedures. The use of 3D-TEE during similar procedures in patients who have undergone Fontan surgery and its additional value have not been previously reported. To determine if live 3D-TEE during procedures post Fontan has added value, 3D-TEEs in 58 post-Fontan patients over a 5-year study period were reviewed. Read More

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http://dx.doi.org/10.1007/s00246-020-02388-xDOI Listing

Epigenetics of paraoxonases.

Curr Opin Lipidol 2020 Jun 1. Epub 2020 Jun 1.

Princip D'Espanya, Miami Platja, Tarragona, Spain.

Purpose Of Review: Studies have shown the three-member paraoxonase (PON) multigene family to be involved in the development of a large variety of diseases with an inflammatory component. Environmental factors such as lifestyle-related factors differ widely between populations and it is important to consider that their impacts may be exerted through the epigenetic mechanisms, which connect genes, the environment and disease development and are a potential therapeutic avenue.

Recent Findings: In the review period, very little was published on epigenetics of PON2 or PON3, mostly on their diagnostic value in cancer by measuring methylation levels of these genes. Read More

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http://dx.doi.org/10.1097/MOL.0000000000000687DOI Listing

Right ventricular function parameters in pulmonary hypertension: echocardiography vs. cardiac magnetic resonance.

BMC Cardiovasc Disord 2020 Jun 1;20(1):259. Epub 2020 Jun 1.

Lund University, Department of Clinical Sciences Lund, Clinical Physiology, Skane University Hospital, Lund, Sweden.

Background: Right ventricular (RV) function is a major determinant of outcome in patients with pulmonary hypertension. Cardiac magnetic resonance (CMR) is gold standard to assess RV ejection fraction (RVEF), however this is a crude measure. New CMR measures of RV function beyond RVEF have emerged, such as RV lateral atrio-ventricular plane displacement (AVPD), maximum emptying velocity (S'), RV fractional area change (FAC) and feature tracking of the RV free wall (FWS). Read More

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http://dx.doi.org/10.1186/s12872-020-01548-4DOI Listing

Changes in REVEAL risk score in patients with pulmonary arterial hypertension treated with macitentan in clinical practice: results from the PRACMA study.

BMC Pulm Med 2020 Jun 2;20(1):154. Epub 2020 Jun 2.

Pulmonary Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background: Macitentan is a dual endothelin receptor antagonist indicated for the long-term treatment of pulmonary arterial hypertension (PAH). We evaluated the change over time in REVEAL risk score in incident and prevalent patients receiving macitentan for the first time.

Methods: Retrospective, observational study including adult patients with idiopathic/heritable PAH or PAH associated with connective tissue disorders or congenital heart disease treated with macitentan for ≥6-month follow-up in Spain. Read More

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http://dx.doi.org/10.1186/s12890-020-01197-5DOI Listing

Survival, Morbidities, and Developmental Outcomes among Low Birth Weight Infants with Congenital Heart Defects.

Am J Perinatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.

Objective:  Prematurity and low birth weight (LBW) are risk factors for increased morbidity and mortality in infants with congenital heart defects (CHDs). We sought to describe survival, inhospital morbidities, and 2-year neurodevelopmental follow-up in LBW infants with CHD.

Study Design:  We included infants with birth weight (BW) <2,500 g diagnosed with CHD (except isolated patent ductus arteriosus) admitted January 2013 to March 2016 to a single level-IV academic neonatal intensive care unit. Read More

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http://dx.doi.org/10.1055/s-0040-1712964DOI Listing

Using Experimental Models to Identify Pathogenic Pathways and Putative Disease Management Targets in Bronchopulmonary Dysplasia.

Authors:
Rory E Morty

Neonatology 2020 Jun 2:1-7. Epub 2020 Jun 2.

Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany,

Bronchopulmonary dysplasia (BPD) is a common and serious complication of preterm birth. Limited pharmacological and other medical interventions are currently available for the management of severely affected, very preterm infants. BPD can be modelled in preclinical studies using experimental animals, and experimental animal models have been extremely valuable in the development of hallmark clinical management strategies for BPD, including pulmonary surfactant replacement and single-course antenatal corticosteroids. Read More

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http://dx.doi.org/10.1159/000506989DOI Listing

Pathological Comparisons of Paraseptal and Centrilobular Emphysema in COPD.

Am J Respir Crit Care Med 2020 Jun 2. Epub 2020 Jun 2.

The University of British Columbia Centre for Heart Lung Innovation, 539747, Vancouver, British Columbia, Canada.

Rationale: While centrilobular (CLE) and paraseptal (PSE) emphysema are commonly identified on multi-detector computed tomography (MDCT), little is known about the pathology associated with PSE compared to CLE.

Objective: To assess the pathological differences between PSE and CLE in chronic obstructive pulmonary disease (COPD).

Methods: Air-inflated frozen lung specimens (n=6) obtained from patients with severe COPD treated by lung transplantation were scanned with MDCT. Read More

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http://dx.doi.org/10.1164/rccm.201912-2327OCDOI Listing

EAACI Biologicals Guidelines - Recommendations for severe asthma.

Allergy 2020 Jun 2. Epub 2020 Jun 2.

University of Wroclaw, Department of Clinical Immunology, Wroclaw, Poland.

Severe asthma imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity, comorbidities, complexity in care pathways and differences between national or regional healthcare systems. Better understanding of the mechanisms has enabled a stratified approach to the management of severe asthma, supporting the use of targeted treatments with biologicals. Read More

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http://dx.doi.org/10.1111/all.14425DOI Listing

Continuous real-time monitoring of pulmonary arterial pressure using a tip deflecting microcatheter in an infant with pulmonary arterial hypertension.

Cardiol Young 2020 Jun 2:1-3. Epub 2020 Jun 2.

Department of Pediatrics, Kyushu Hospital, Japan Community Healthcare Organization, Japan.

We present the case of a 3-month-old boy with pulmonary arterial hypertension after corrective repair of total anomalous pulmonary venous connection. The patient developed severe pulmonary arterial hypertension with a high mean pulmonary arterial pressure of 45 mmHg. We performed continuous monitoring of pulmonary arterial pressure using a tip deflecting microcatheter in the intensive care unit. Read More

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http://dx.doi.org/10.1017/S1047951120001286DOI Listing

Bronchoscopic Interventions as a Management of Airway Complications After Lung Transplant Including Assessment of Risk Factors With Special Consideration for Pretransplant Pulmonary Hypertension.

Transplant Proc 2020 May 29. Epub 2020 May 29.

Silesian Center for Heart Diseases, Zabrze, Poland; Department of Cardiac, Vascular, and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland.

Background: Lung transplant (LTx) is a procedure associated with risk of complications related to airway stenosis that can be treated with bronchoscopic interventions (BIs). The aim of the study was to assess the frequency and risk factors associated with increased need of bronchial interventions in the post-transplant period.

Methods: The retrospective study reviewed cases of 165 patients (63 women) who underwent LTx from April 2013 to June 2019. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.03.045DOI Listing

Pneumonia in hospitalized elderly hip fracture patients: the effects on length of hospital-stay, in-hospital and thirty-day mortality and a search for potential predictors.

Injury 2020 May 21. Epub 2020 May 21.

Department of Trauma Surgery, ZGT, Netherland.

Background: Hip fracture in the elderly is associated with increased morbidity and mortality. Pneumonia during hospitalization is not uncommon and is associated with poorer outcomes, such as an increased risk of readmission and higher mortality rates. We aim to identify independent predictive factors for developing pneumonia during hospitalization in this group and also assessed the effect pneumonia has on hospital-stay, in-hospital and 30-day mortality. Read More

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http://dx.doi.org/10.1016/j.injury.2020.05.017DOI Listing

Prevalence of Coronary Artery Calcification on Pre-Atrial Fibrillation Ablation CT Pulmonary Venograms and its Impact on Selection for Statin Therapy.

J Clin Med 2020 May 28;9(6). Epub 2020 May 28.

Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Atherosclerotic cardiovascular disease (ASCVD) shares many risk factors with atrial fibrillation (AF). Obtaining computed tomography images of the pulmonary veins (CTPV) before AF ablation procedures is common and can incidentally detect coronary artery calcification (CAC). The purpose of this study was to investigate the prevalence of CAC on pre-ablation CTPV, the frequency of CAC reporting on CTPV reports, and its impact on statin therapy among patients hospitalized for AF procedures. Read More

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http://dx.doi.org/10.3390/jcm9061631DOI Listing

On the Relevance of the Loss Function in the Agatston Score Regression from Non-ECG Gated CT Scans.

Image Anal Mov Organ Breast Thorac Images (2018) 2018 Sep 12;11040:326-334. Epub 2018 Sep 12.

Applied Chest Imaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

In this work, we evaluate the relevance of the choice of loss function in the regression of the Agatston score from 3D heart volumes obtained from non-contrast non-ECG gated chest computed tomography scans. The Agatston score is a well-established metric of cardiovascular disease, where an index of coronary artery disease (CAD) is computed by segmenting the calcifications of the arteries and multiplying each calcification by a factor related to their intensity and their volume, creating a final aggregated index. Recent work has automated such task with deep learning techniques, even skipping the segmentation step and performing a direct regression of the Agatston score. Read More

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http://dx.doi.org/10.1007/978-3-030-00946-5_33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258442PMC
September 2018

Electrical Storm in Patients with Implantable Cardioverter-defibrillators: A Practical Overview.

J Innov Card Rhythm Manag 2017 Oct 15;8(10):2853-2861. Epub 2017 Oct 15.

Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA.

Electrical storm (ES) is an increasingly common medical emergency characterized by clustered episodes of sustained ventricular arrhythmias (VAs) that lead to repeated appropriate implantable cardioverter-defibrillator (ICD) therapies. A diagnosis of ES can be made with the occurrence of three or more sustained episodes of VAs, or of three or more appropriate ICD therapies within 24 hours in patients with implanted devices. ES is associated with poor outcomes in patients with structural heart disease, particularly those with severe left ventricular dysfunction. Read More

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http://dx.doi.org/10.19102/icrm.2017.081002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252660PMC
October 2017

Diffuse alveolar hemorrhage: how relevant is etiology?

Sarcoidosis Vasc Diffuse Lung Dis 2019 1;36(1):47-52. Epub 2019 May 1.

Pulmonology Department, Centro Hospitalar de Trás-os-Montes e Alto Douro.

Background: Diffuse Alveolar Hemorrhage (DAH) is a rare and potentially life-threatening clinical syndrome whose early recognition is essential.

Objectives: Characterization of patients with DAH and comparison of presentation and evolution of the disease according to etiology.

Methods: We retrospectively reviewed the clinical records of patients admitted to our hospital over a 7-year period with DAH. Read More

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http://dx.doi.org/10.36141/svdld.v36i1.7160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247111PMC

Sensitivity and specificity of chest imaging for sarcoidosis screening in patients with cardiac presentations.

Sarcoidosis Vasc Diffuse Lung Dis 2019 1;36(1):18-24. Epub 2019 May 1.

Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, ON.

Background: Patients with sarcoidosis can present with cardiac symptoms as the first manifestation of disease in any organ. In these patients, the use of chest imaging modalities may serve as an initial screening tool towards the diagnosis of sarcoidosis through identification of pulmonary/mediastinal involvement; however, the use of chest imaging for this purpose has not been well studied. We assessed the utility of different chest imaging modalities for initial screening for cardiac sarcoidosis (CS). Read More

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http://dx.doi.org/10.36141/svdld.v36i1.6865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247116PMC

Validation of 4-meter-gait-speed test and 5-repetitions-sit-to-stand test in patients with pulmonary fibrosis: a clinimetric validation study.

Sarcoidosis Vasc Diffuse Lung Dis 2018 9;35(4):317-326. Epub 2020 Mar 9.

Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands.

Patients with pulmonary fibrosis (PF) have a clear exercise intolerance. The 4-meter-gait-speed (4MGS) test and the 5-repetitions-sit-to-stand (5STS) test are easy, inexpensive and reliable measures of functional performance. Both tests have been validated in healthy adults and patients with chronic obstructive pulmonary disease. Read More

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http://dx.doi.org/10.36141/svdld.v35i4.7035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170119PMC