65,241 results match your criteria Cor Pulmonale


Diagnostic evaluation and cardiopulmonary exercise test findings in young athletes with persistent symptoms following COVID-19.

Br J Sports Med 2022 May 18. Epub 2022 May 18.

Cardiovascular Performance Program, Massachusetts General Hospital, Boston, Massachusetts, USA

Objectives: Persistent or late-onset cardiopulmonary symptoms following COVID-19 may occur in athletes despite a benign initial course. We examined the yield of cardiac evaluation, including cardiopulmonary exercise testing (CPET), in athletes with cardiopulmonary symptoms after COVID-19, compared CPETs in these athletes and those without COVID-19 and evaluated longitudinal changes in CPET with improvement in symptoms.

Methods: This prospective cohort study evaluated young (18-35 years old) athletes referred for cardiopulmonary symptoms that were present>28 days from COVID-19 diagnosis. Read More

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Incidental chest findings on coronary CT angiography: a pictorial essay and management proposal.

J Bras Pneumol 2022 13;48(4):e20220015. Epub 2022 May 13.

. Imaging Department, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, United Kingdom.

Many health systems have been using coronary CT angiography (CCTA) as a first-line examination for ischaemic heart disease patients in various countries. The rising number of CCTA examinations has led to a significant increase in the number of reported incidental extracardiac findings, mainly in the chest. Pulmonary nodules are the most common incidental findings on CCTA scans, as there is a substantial overlap of risk factors between the population seeking to exclude ischaemic heart disease and those at risk of developing lung cancer (i. Read More

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Reduction of Lung Hyperinflation Improves Cardiac Preload, Contractility, and Output in Emphysema: A Prospective Cardiac Magnetic Resonance Study in Patients Who Received Endobronchial Valves.

Am J Respir Crit Care Med 2022 May 18. Epub 2022 May 18.

University Medical Center Groningen, Pulmonary diseases, Groningen, Netherlands.

Rationale: Pulmonary hyperinflation in patients with Chronic Obstructive Pulmonary Disease (COPD) has been related to smaller cardiac chamber sizes and impaired cardiac function. Nowadays, bronchoscopic lung volume reduction (BLVR) with endobronchial valves is a treatment option to reduce pulmonary hyperinflation in patients with severe emphysema.

Objectives: We hypothesized that reduction of hyperinflation would improve cardiac preload in this patient group. Read More

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Effectiveness of a Home-Based Pulmonary Rehabilitation Program in Veterans.

Telemed J E Health 2022 May 17. Epub 2022 May 17.

VA Office of Rural Health (ORH), Veterans Rural Health Resource Center-Iowa City, Iowa City VA Healthcare System, Iowa City, Iowa, USA.

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Hispanic ethnicity and mortality among critically ill patients with COVID-19.

PLoS One 2022 18;17(5):e0268022. Epub 2022 May 18.

Department of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, IL, United States of America.

Background: Hispanic persons living in the United States (U.S.) are at higher risk of infection and death from coronavirus disease 2019 (COVID-19) compared with non-Hispanic persons. Read More

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Predictive Value of C2HEST Score for Atrial Fibrillation Recurrence Following Successful Cryoballoon Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation.

Angiology 2022 May 18:33197221102230. Epub 2022 May 18.

Department of Cardiology, 147003Bursa Yüksek İhtisas Training and Research Hospital, İzmir, Turkey.

The C2HEST score ((coronary artery disease (CAD) or chronic obstructive pulmonary disease (COPD) [C2, 1 point each]; hypertension [H, 1 point]; elderly [E, age ≥75 years, 2 points]; systolic heart failure [S, 2 points]; thyroid disease [T, hyperthyroidism, 1 point]) has been validated for predicting incidental atrial fibrillation (AF) in both the general population and patients with ischemic stroke. The present study evaluated the performance of this score in predicting AF recurrence in 252 patients following cryoballoon ablation (CRYO) for paroxysmal AF. The AF recurrence rate in 3-12 months following CRYO was 20,2%. Read More

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Apixaban vs. standard of care after transcatheter aortic valve implantation: the ATLANTIS trial.

Eur Heart J 2022 May 18. Epub 2022 May 18.

Sorbonne Université, ACTION Group, INSERM UMRS 1166, Hôpital Pitié-Salpêtrière (AP-HP), Institut de Cardiologie, Paris 75013, France.

Aims: The respective roles of oral anticoagulation or antiplatelet therapy following transcatheter aortic valve implantation (TAVI) remain debated. ATLANTIS is an international, randomized, open-label, superiority trial comparing apixaban to the standard of care.

Methods And Results: After successful TAVI, 1500 patients were randomized (1:1) to receive apixaban 5 mg (2. Read More

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Infradiaphragmatic partial anomalous pulmonary venous connection in adulthood. Considerations for management: a single centre experience.

Cardiol Young 2022 May 18:1-5. Epub 2022 May 18.

Department of Cardiology and Grown-up Congenital Heart Disease, ICLAS, Rapallo, GE, Italy.

Background And Objectives: Infradiaphragmatic partial anomalous pulmonary venous connection is occasionally diagnosed in adulthood. Management of infradiaphragmatic PAPVC depends on anatomy and clinical presentation.

Methods: Over a 10-year period, we observed seven adult patients (median age 29 years) with partial anomalous pulmonary venous connection. Read More

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Evolving Concepts in Endothelial Pathobiology of Pulmonary Arterial Hypertension.

Hypertension 2022 May 18:101161HYPERTENSIONAHA12218261. Epub 2022 May 18.

Ottawa Hospital Research Institute, ON, Canada (N.D.C., D.J.S.).

Pulmonary arterial hypertension (PAH) is a deadly disease, characterized by increased vascular resistance, pulmonary arteriolar loss, and occlusive arterial remodeling, leading to eventual right heart failure. Evidence increasingly points to the pulmonary endothelium as a central actor in PAH. Endothelial cell apoptosis can result directly in distal lung arteriolar pruning and indirectly in the formation of complex and occlusive arterial lesions, reflecting an imbalance between endothelial injury and repair in the development and progression of PAH. Read More

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Clinical Implications of Airway Anomalies and Stenosis in Patients with Heterotaxy Syndrome.

Pediatr Pulmonol 2022 May 18. Epub 2022 May 18.

Department of Radiology, National Taiwan University Hospital and Medical College, National Taiwan University, Taipei, Taiwan.

In heterotaxy syndrome, bronchopulmonary situs usually reflects atrial situs, resulting in either right (RAI) or left atrial isomerism (LAI). This study determines airway anomalies and its implications in patients with heterotaxy. This retrospective study included 223 patients with heterotaxy syndrome who received an integrated cardiac computed tomography evaluation. Read More

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Phenotyping in heart failure with preserved ejection fraction: A key to find effective treatment.

Adv Clin Exp Med 2022 May 18. Epub 2022 May 18.

1st Chair and Department of Cardiology, Medical University of Warsaw, Poland.

Heart failure with preserved ejection fraction (HFpEF) is an increasingly widespread medical condition, with excessive morbidity and mortality. Recently, for the first time in HFpEF, a reduction in the primary composite outcome of cardiovascular death or HF hospitalization was shown with empagliflozin. The failure of previous clinical trials in HFpEF might have resulted from suboptimal patient selection and inclusion of patients without "true" or clinically significant HFpEF. Read More

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Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis.

Exp Mol Med 2022 May 17. Epub 2022 May 17.

Departments of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.

Overwhelming neutrophilic inflammation is a leading cause of lung damage in many pulmonary diseases, including cystic fibrosis (CF). The heme oxygenase-1 (HO-1)/carbon monoxide (CO) pathway mediates the resolution of inflammation and is defective in CF-affected macrophages (MΦs). Here, we provide evidence that systemic administration of PP-007, a CO releasing/O transfer agent, induces the expression of HO-1 in a myeloid differentiation factor 88 (MyD88) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)-dependent manner. Read More

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Using the CHEST Score for Predicting Postoperative Atrial Fibrillation After Cardiac Surgery: A Report From the Western Denmark Heart Registry, the Danish National Patient Registry, and the Danish National Prescription Registry.

J Cardiothorac Vasc Anesth 2022 Apr 6. Epub 2022 Apr 6.

Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Atrial Fibrillation Study Group, Aalborg University Hospital, Aalborg, Denmark.

Objectives: New-onset postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery. A targeted approach is necessary for prophylactic handling of the complication. The authors tested the performance of the CHEST score to predict POAF in patients undergoing cardiac surgery. Read More

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Challenges in managing a critically ill patient with decompensated Eisenmenger syndrome.

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Anaesthesiology and Intensive Care Department, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia

Eisenmenger syndrome (ES) is the most severe form of pulmonary arterial hypertension and is associated with congenital heart disease. ES itself is a challenging condition to manage, further compounded if the patient is critically ill and acutely decompensated. We share our experience of managing a critically ill adult patient with ES who presented with acute decompensation due to sepsis. Read More

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Pulmonary Congestion During Exercise Stress Echocardiography in Ischemic and Heart Failure Patients.

Circ Cardiovasc Imaging 2022 May 17;15(5):e013558. Epub 2022 May 17.

Highly Specialized Rehabilitation Hospital Motta di Livenza, Cardiac Prevention and Rehabilitation Unit, Treviso, Italy (F.A.-C.).

Background: Lung ultrasound detects pulmonary congestion as B-lines at rest, and more frequently, during exercise stress echocardiography (ESE).

Methods: We performed ESE plus lung ultrasound (4-site simplified scan) in 4392 subjects referred for semi-supine bike ESE in 24 certified centers in 9 countries. B-line score ranged from 0 (normal) to 40 (severely abnormal). Read More

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Twenty-year experience and outcomes in a National Pediatric Pulmonary Hypertension Service.

Am J Respir Crit Care Med 2022 May 17. Epub 2022 May 17.

Great Ormond Street Hospital for Children, 4956, national paediatric pulmonary hypertension service, London, United Kingdom of Great Britain and Northern Ireland;

Rationale Pediatric pulmonary hypertension is an important cause of childhood morbidity and mortality, but there are limited data on the range of associated diseases, contributions of different pulmonary hypertension subtypes, therapeutic strategies, and clinical outcomes in children. Objectives To report the 20-year experience of a large UK National Pediatric Pulmonary Hypertension Service focusing on epidemiology and clinical outcomes. Methods Consecutive patients presenting between 2001 and 2021 were included and survival analysis was performed for incident patients. Read More

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Cardiovascular Benefit of CPAP in Adults with Coronary Artery Disease and OSA without Excessive Sleepiness.

Am J Respir Crit Care Med 2022 May 17. Epub 2022 May 17.

Brigham and Women's Hospital, 1861, Boston, Massachusetts, United States.

Rational: Randomized controlled trials of continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA) have not demonstrated protection against adverse cardiovascular outcomes. Recently, observational studies revealed that OSA-related cardiovascular risk is concentrated in patients with an elevated pulse rate response to respiratory events (ΔHR). Here, in this post-hoc analysis of a prospective clinical trial, we test the hypothesis that a greater pre-treatment ΔHR is associated with greater CPAP-related protection against adverse cardiovascular outcomes. Read More

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Validation for EuroSCORE II in the Indonesian cardiac surgical population: a retrospective, multicenter study.

Expert Rev Cardiovasc Ther 2022 May 17. Epub 2022 May 17.

Faculty of Medicine, Public health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Background: In 2011, the European System for Cardiac Operative Risk (EuroSCORE) II was created as an improvement of the additive/logistic EUROScore for the prediction of mortality after cardiac surgery.

Objective: To validate EuroSCORE II in predicting the mortality of open cardiac surgery patients in Indonesia.

Methods: We performed a multi-center retrospective study of cardiac surgery patients. Read More

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Chronic diseases and comorbidities in adults with and without intellectual disabilities: comparative cross-sectional study in Dutch general practice.

Fam Pract 2022 May 17. Epub 2022 May 17.

Radboud Institute for Health Sciences, Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Chronic disease and comorbidity patterns in people with intellectual disabilities (ID) are more complex than in the general population. However, incomplete understanding of these differences limits care providers in addressing them.

Objective: To compare chronic disease and comorbidity patterns in chronically ill patients with and without ID in Dutch general practice. Read More

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The association between cardiac involvement and long-term clinical outcomes in patients with Duchenne muscular dystrophy.

ESC Heart Fail 2022 May 17. Epub 2022 May 17.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Aims: Despite advances in contemporary cardiopulmonary therapies, cardiomyopathy remains the leading cause of death in patients with Duchenne muscular dystrophy (DMD). Also, the long-term clinical outcomes of patients with DMD and cardiomyopathy is unknown. This study investigated long-term clinical outcomes and their associated factors in patients with late-stage DMD. Read More

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Tetralogy of Fallot in the fetus - from diagnosis to delivery. 18-year experience of a tertiary Fetal Cardiology Center.

Kardiol Pol 2022 May 17. Epub 2022 May 17.

Department of Perinatal Cardiology and Congenital Anomalies, Center of Postgraduate Medical Education, Warszawa, Poland.

Background: Tetralogy of Fallot (TOF) is a common congenital heart disease, however very heterogenous in terms of detailed cardiac anatomy, associated malformations and genetic anomalies, especially when assessed prenatally.

Aims: Our aim was to analyze the clinical spectrum of TOF in the prenatal period, including detailed cardiac morphology, coexisting anomalies, and their impact on short-term neonatal outcome. We also assessed changing trends in the prenatal diagnostic workup of TOF. Read More

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Molecular determinants, clinical manifestations and effects of immunization on cardiovascular health during COVID-19 pandemic era - A review.

Curr Probl Cardiol 2022 May 13:101250. Epub 2022 May 13.

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India. Electronic address:

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has enveloped the world into an unprecedented pandemic since 2019. Significant damage to multiple organs, such as the lungs and heart, has been extensively reported. Cardiovascular injury by ACE2 downregulation, hypoxia-induced myocardial injury, and systemic inflammatory responses complicate the disease. Read More

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Impact of pulmonary hypertension in patients with hypertrophic cardiomyopathy presented with cardiogenic shock/acute decompensated heart failure.

Curr Probl Cardiol 2022 May 13:101251. Epub 2022 May 13.

New York Medical College at Westchester Medical Center, New York, NY, USA. Electronic address:

Introduction: There have been no studies focusing on how pulmonary hypertension (PH) affects inpatient outcomes in patients with hypertrophic cardiomyopathy (HCM) hospitalized for acute decompensated heart failure or cardiogenic shock. This study explores inpatient outcomes of patients with HCM, and concomitant PH compared to patients with HCM.

Methods: Based on the National Inpatient Sample (NIS) 2016-2018, patients admitted with a primary diagnosis of acute decompensated heart failure or cardiogenic shock were selected. Read More

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[Clinical and prognostic profile evolution of patients discharged from hospital due to heart failure in the first two decades of the 21st century. The INCA-Ex Registry].

Aten Primaria 2022 May 13;54(7):102357. Epub 2022 May 13.

Unidad de Investigación, Área de Salud Don Benito-Villanueva, Servicio Extremeño de Salud, Villanueva de la Serena, Badajoz, España; Centro de Salud Mérida Urbano I, Mérida, Badajoz, España.

Aim: To study the evolution of the clinical profile of a population discharged with a main diagnosis of heart failure (HF) in the first two decades of the century and the predictive variables of mortality and readmission in the first year of discharge.

Design: Observational, retrospective, longitudinal study. SITE: Don Benito Villanueva de la Serena Badajoz health area. Read More

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Early signs of sleep-disordered breathing in healthy women predict carotid intima-media thickening after 10 years.

Sleep Med 2022 Apr 23;96:8-13. Epub 2022 Apr 23.

Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland; Department of Anesthesiology and Intensive Care, Turku University Hospital and University of Turku University of Turku, Turku, Finland; Division of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland.

Background: Cardiovascular disease (CVD) is the leading cause of death in women. The risk of CVD increases in women after menopause. The aim was to study how sleep parameters and cardiovascular risk factors in 46-year-old women predict future carotid intima-media thickness (IMT) 10 years after. Read More

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Predictive Value of Coronary Artery Calcium in Patients Receiving Computed Tomography Pulmonary Angiography for Suspected Pulmonary Embolism in the Emergency Department.

J Thorac Imaging 2022 May 9. Epub 2022 May 9.

Department of Radiology, University of Washington, Seattle, WA.

Purpose: Coronary artery calcium (CAC) is a frequent incidental finding on computed tomography pulmonary angiogram (CTPA) in the evaluation of pulmonary embolism (PE) in the emergency department (ED); however, its prognostic value is unclear. In this study, we interrogate the prognostic value of CAC identified on CTPA in predicting adverse outcomes in the evaluation of PE in the ED.

Materials And Methods: In this retrospective cohort study, we identified 610 patients presenting to the ED in 2013 and evaluated with CTPA for suspected PE. Read More

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A Phase 1 Dose Escalation Study of the Pyruvate Kinase Activator Mitapivat (AG-348) in Sickle Cell Disease.

Blood 2022 May 16. Epub 2022 May 16.

NHLBI / NIH, Bethesda, Maryland, United States.

Polymerization of deoxygenated hemoglobin S (HbS) underlies the pathophysiology of sickle cell disease (SCD). In activating red blood cell pyruvate kinase and glycolysis, mitapivat (AG-348) increases adenosine triphosphate (ATP) levels and decreases the 2,3-diphosphoglycerate (2,3-DPG) concentration, an upstream precursor in glycolysis. Both changes have therapeutic potential for patients with SCD. Read More

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Paediatric Thrombosis: A Five-Year Experience From A Tertiary Care Center Of Pakistan.

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):263-268

CMH Medical College and Institute of Dentistry, Karachi, Pakistan.

Background: Advances in imaging techniques and longer survival of chronic medical conditions contribute to the increase in paediatric thrombosis. We aim to determine the incidence, underlying risk factors, management and clinical outcome of paediatric thrombosis at a multidisciplinary facility of Pakistan.

Methods: A retrospectively analysis of the medical records of patients in the paediatric age group admitted at the Aga Khan University hospital from January 2013-September 2018 was performed. Read More

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Exploration of the feasibility to combine patients with chronic obstructive pulmonary disease and chronic heart failure in self-management groups with focus on exercise self-efficacy.

Scand J Prim Health Care 2022 May 16:1-9. Epub 2022 May 16.

Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Objective: To compare the level of exercise self-efficacy, symptoms, functional capacity and health status and investigate the association between these variables in patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF). Additionally, to investigate how diagnosis, symptoms and patient characteristics are associated with exercise self-efficacy in these patient groups.

Design: Cross-sectional study. Read More

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Pulmonary artery systolic pressure at 1-month predicts one-year survival after transcatheter aortic valve implantation.

Kardiol Pol 2022 May 16. Epub 2022 May 16.

Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznań, Poland.

Background: Pulmonary hypertension related to left ventricle heart disease is a common finding in patients with severe aortic stenosis treated with transcatheter aortic valve implantation (TAVI) and is associated with higher mortality rate.

Aims: The aim of the study was to analyze the influence of pulmonary artery systolic pressure (PASP) changes after TAVI on long-term survival.

Methods: TAVI was performed in 362 patients between January 2013 and December 2018. Read More

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