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Aerosp Med Hum Perform 2019 Jan;90(1):12-17

Precooling (PC) before exercise may help prevent severe hyperthermia and exertional heatstroke (EHS). Before clinicians can advocate PC as an EHS prevention strategy, it must effectively mitigate factors associated with EHS development while not lessening the effectiveness of EHS treatment. Therefore, this study determined if PC affected rectal temperature (T), body heat storage, heart rate (HR), ratings of perceived exertion (RPE), thermal sensation, sweat rate, and postexercise cold-water immersion (CWI) T cooling rates. Read More

Pediatr Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

PICU, Hospital General Universitario Gregorio Marañon, Universidad Complutense de Madrid, Maternal and Child Health and Development Network (Red SAMID), Madrid, Spain.

Objectives: It is currently recommended that after return of spontaneous circulation following cardiac arrest, fever should be prevented using TTM through a servo-controlled system. This technology is not yet available in many global settings, where manual physical measures without servo-control is the only option. Our aim was to compare feasibility, safety and quality assurance of servo-controlled system versus no servo-controlled system cooling, TTM protocols for cooling, maintenance and rewarming following return of spontaneous circulation after cardiac arrest in children. Read More

J Therm Biol 2018 Dec 1;78:329-342. Epub 2018 Nov 1.

Department of Mechanical Engineering, NIT Arunachal Pradesh, Yupia 791112, India. Electronic address:

Attaining a precise necrosis of tumor sparing normal tissue during carcinomas thermo-therapy via nominally invasive scheme like irradiation of laser is a recent challenge. In this study, a combined diffusion and convective energy equations were solved using COMSOL Multiphysics to predict the tissue thermal profile during laser assisted thermo-therapy with different tissue vascular networks. A comparative analysis between intratumoral and intravenous loading scheme of silica-gold nanoshells (AuNs) was also performed. Read More

Int J Hyperthermia 2018 Nov 28:1-12. Epub 2018 Nov 28.

d Department of Information Engineering , University of Florence , Firenze , Italy.

Purpose: Bleeding from parenchyma transection during a robotic hepatic surgery remains the most critical point affecting postoperative recovery and long-term survival. Various robotic devices with different types of energies have been proposed; however, each of these lack in steerability, efficacy, or accuracy. The aim of this work is to evaluate the feasibility and performance of a new steerable microwave resection device intended for minimizing intraoperative blood loss during laparoscopic and robotic liver resections. Read More

Resuscitation 2018 Oct 22. Epub 2018 Oct 22.

Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Purpose: Early initiation of hypothermia is recommended in the setting of cardiac arrest. Current hypothermia methods are invasive and expensive and not applicable in ambulatory settings. We investigated the evaporative cooling effect of high flow transnasal dry air on core esophageal temperature in human volunteers. Read More

Eur J Sport Sci 2018 Oct 10:1-10. Epub 2018 Oct 10.

f School of Health and Human Sciences , Southern Cross University , Coffs Harbour , Australia.

Purpose: To characterize player core temperature (Tc) across two separate World Rugby Sevens Series (WRSS) tournaments in temperate and warm environments.

Methods: Tc was collected in seventeen playing members of one men's team competing at the Singapore (n = 12) and London (n = 11) WRSS tournaments. Exertional heat illness (EHI) symptoms, cooling strategy use, playing minutes and wet blub globe temperature (WBGT) were also collected. Read More

J Ther Ultrasound 2018 13;6. Epub 2018 Aug 13.

1Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, Box 0946, San Francisco, CA 94107 USA.

Background: Hyperthermia therapy (HT) has shown to be an effective adjuvant to radiation, chemotherapy, and immunotherapy. In order to be safe and effective, delivery of HT requires maintenance of target tissue temperature within a narrow range (40-44 °C) for 30-60 min, which necessitates conformal heat delivery and accurate temperature monitoring. The goal of this project was to develop an MR thermometry-guided hyperthermia delivery platform based upon the ExAblate prostate array that would achieve uniform stable heating over large volumes within the prostate, while allowing the user to precisely control the power deposition patterns and shape of the region of treatment (ROT). Read More

Neurocrit Care 2018 Aug 10. Epub 2018 Aug 10.

UniversitatsSpital Zurich, Zurich, Switzerland.

Background: Fever control plays a key role in therapy of patients with acute brain injury. The infusion of cold saline could serve as an alternative or additional method for targeted temperature management. However, it is difficult to estimate the amount of fluid required to achieve normothermia merely on the basis of body weight. Read More

Ther Hypothermia Temp Manag 2018 09 10;8(3):126-130. Epub 2018 Aug 10.

4 Department of Surgery, Harborview Center for Prehospital Emergency Care , Seattle, Washington.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Anaesthesia and Intensive Care, Mater Dei Hospital, Msida, Malta.

A 31-year-old man was brought to Accident & Emergency after collapsing during a race. On presentation, the patient had a temperature of 41.7°C (rectal). Read More

Int J Hyperthermia 2018 28;35(1):44-55. Epub 2018 May 28.

a Institute for Critical Technology and Applied Science, Virginia Tech , Blacksburg , VA , USA.

Purpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and temperature changes using a perfused porcine liver model.

Materials And Methods: A bipolar electrode delivered IRE electric pulses with or without activation of internal cooling to nine porcine mechanically perfused livers. Pulse schemes included a constant voltage, and a preconditioned delivery combined with an arc-mitigation algorithm. Read More

J Therm Biol 2018 May 26;74:264-274. Epub 2018 Apr 26.

School of Energy Science and Engineering, Harbin Institute of Technology, Harbin 150001, PR China. Electronic address:

Thermal therapy is a very promising method for cancer treatment, which can be combined with chemotherapy, radiotherapy and other programs for enhanced cancer treatment. In order to get a better effect of thermal therapy in clinical applications, optimal internal temperature distribution of the tissue embedded with gold nanoparticles (GNPs) for enhanced thermal therapy was investigated in present research. The Monte Carlo method was applied to calculate the heat generation of the tissue embedded with GNPs irradiated by continuous laser. Read More

Respir Investig 2018 Jul 10;56(4):356-360. Epub 2018 May 10.

Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. Electronic address:

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high diagnostic yield in lesions adjacent to the airways. However, complications associated with EBUS-TBNA, such as mediastinitis, have recently been reported. Oral bacteria contamination in punctured lymph nodes can cause severe infections. Read More

Pacing Clin Electrophysiol 2018 Apr 16. Epub 2018 Apr 16.

Department of Cardiology, Medical University of Graz, Graz, Austria.

Objective: Application of therapeutic mild hypothermia in patients after resuscitation, often accompanied by myocardial infarction, cardiogenic shock, and systemic inflammation may impact on cardiac rhythm. We therefore tested susceptibility to atrial arrhythmias during hyperthermia (HT, 40.5°C), normothermia (NT, 38. Read More

Crit Care 2018 Apr 13;22(1):90. Epub 2018 Apr 13.

Department of Intensive Care and Erasmus MC Stroke Center, Erasmus Medical Center, Rotterdam, the Netherlands.

Background: General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess and quantify variation in perceptions on intensive care unit (ICU) management of patients with TBI in European neurotrauma centers.

Methods: We performed a survey as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Read More

PLoS One 2018 29;13(3):e0195219. Epub 2018 Mar 29.

Department of Kinesiology, Brock University, St. Catharines, Ontario, Canada.

The large body of work demonstrating hyperthermic impairment of neuromuscular function has utilized maximal isometric contractions, but extrapolating these findings to whole-body exercise and submaximal, dynamic contractions may be problematic. We isolated and compared core and skin temperature influences on an isometric force task versus a position task requiring dynamic maintenance of joint angle. Surface electromyography (sEMG) was measured on the flexor carpi radialis at 60% of baseline maximal voluntary contraction while either pushing against a rigid restraint (force task) or while maintaining a constant wrist angle and supporting an equivalent inertial load (position task). Read More

Appl Physiol Nutr Metab 2018 Aug 12;43(8):857-860. Epub 2018 Mar 12.

c Human and Environmental Physiological Research Unit, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

We examined if physical characteristics could be used to predict cooling time during cold water immersion (CWI, 2 °C) following exertional hyperthermia (rectal temperature ≥39.5 °C) in a physically heterogeneous group of men and women (n = 62). Lean body mass was the only significant predictor of cooling time following CWI (R = 0. Read More

JBI Database System Rev Implement Rep 2018 Mar;16(3):791-801

School of Nursing, Fudan University, Shanghai, P.R. China.

Objectives: The aim of this evidence implementation project was to integrate the best available evidence on non-pharmacological fever and febrile symptom management into nursing practice at the Shanghai Public Health Clinical Centre, China.

Introduction: Fever is challenging for patients with the human immunodeficiency virus (HIV). Guidelines assert that successful non-pharmacological fever management should be the standard of care. Read More

Indian J Crit Care Med 2018 Jan;22(1):43-45

Post-Graduate Institute of Neurological Surgery, Dr. Achanta Lakshmipathi Neurosurgical Centre, Voluntary Health Services Multi-speciality Hospital and Research Centre, Chennai, Tamil Nadu, India.

Hyperpyrexia is a rare and at times fatal condition seen in an Intensive Care Unit setup. We encountered a case of a 65-year-old patient with road traffic accident presenting with dorsal spine fracture at D level. He underwent decompression and fusion for the same. Read More

J Vis Exp 2017 11 21(129). Epub 2017 Nov 21.

Attune Medical; Department of Emergency Medicine, University of Texas, Southwestern Medical Center;

Controlling patient temperature is important for a wide variety of clinical conditions. Cooling to normal or below normal body temperature is often performed for neuroprotection after ischemic insult (e.g. Read More

Ann Phys Rehabil Med 2018 Mar 11;61(2):72-77. Epub 2017 Dec 11.

School of Health Professions, Faculty of Health and Human Sciences, Plymouth University, Peninsula Allied Health Centre, Derriford Road, Plymouth, PL6 8BH, United Kingdom.

Objectives: Cooling of the lower limb in people with Hereditary and Spontaneous Spastic Paraparesis (pwHSSP) has been shown to affect walking speed and neuromuscular impairments. The investigation of practical strategies, which may help to alleviate these problems is important. The potential of superficial heat to improve walking speed has not been explored in pwHSSP. Read More

Ann Vasc Surg 2018 Apr 5;48:67-74. Epub 2017 Dec 5.

Department of Surgical Specialties, Tokyo Medical and Dental University, Tokyo, Japan.

Background: We previously reported the utility of the perfusion value (PV) fluctuation slope for detecting severe ischemia in the lower limb. Our approach was based on a thermal load test mimicking the well-known physiological reaction termed "cold-induced vasodilation," which is known to occur as a 3-phase phenomenon. The slope parameter quantifies the decrease in PVs accompanying the relative cooling (third phase) following the transient increase in blood flow (second phase) induced by the applied thermal load. Read More

J Neurosurg Pediatr 2018 02 1;21(2):164-170. Epub 2017 Dec 1.

1Division of Critical Care and.

OBJECTIVE Severe traumatic brain injury remains a leading cause of morbidity and mortality in the pediatric population. Providers focus on reducing secondary brain injury by avoiding hypoxemia, avoiding hypotension, providing normoventilation, treating intracranial hypertension, and reducing cerebral metabolic demand. Hyperthermia is frequently present in patients with severe traumatic brain injury, contributes to cerebral metabolic demand, and is associated with prolonged hospital admission as well as impaired neurological outcome. Read More

Eur Heart J Acute Cardiovasc Care 2018 Aug 27;7(5):467-477. Epub 2017 Nov 27.

3 Division of Cardiology, University of British Columbia, Canada.

Aims: The purpose of this study was to conduct a systematic review, and where applicable meta-analyses, examining the evidence underpinning the use of targeted temperature management following resuscitation from cardiac arrest.

Methods And Results: Multiple databases were searched for publications between January 2000-February 2016. Nine Population, Intervention, Comparison, Outcome questions were developed and meta-analyses were performed when appropriate. Read More

Eur Rev Med Pharmacol Sci 2017 Oct;21(4 Suppl):50-53

Department of Neonatology, Xunzhou Children's Hospital, Xuzhou, Jiangsu, China.

Neonatal hypoxic-ischemic encephalopathy (HIE) significantly affects neurodevelopment in infants and is also considered as an important cause of neonatal deaths worldwide. Medical research is being focused worldwide for the development of therapeutic avenues but it is still managed by supportive care. The latest studies in the above field have shown the efficacy of prolonged cooling of neonate's head or whole body at the age of 18 months (approx. Read More

Rev Cardiovasc Med 2017 ;18(3):115-122

Department of Cardiovascular Medicine, Beaumont Health, Royal Oak, MI.

Atrioesophageal fistula (AEF) is a rare but catastrophic complication of catheter ablation of atrial fibrillation (AF), with an incidence of 0.03% to 1.5% per year. Read More

J Anaesthesiol Clin Pharmacol 2017 Jul-Sep;33(3):306-316

Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

Administration of general anesthesia requires continuous monitoring of vital parameters of the body including body temperature. However, temperature continues to be one of the least seriously monitored parameters perioperatively. Inadvertent perioperative hypothermia is a relatively common occurrence with both general and regional anesthesia and can have significant adverse impact on patients' outcome. Read More

Eur J Appl Physiol 2018 Jan 28;118(1):101-109. Epub 2017 Oct 28.

Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.

Purpose: To determine the impact of local muscle heating and cooling on myogenic and proteolytic gene responses following resistance exercise.

Methods: Recreationally trained males (n = 12), age 25.3 ± 1. Read More

Neurocrit Care 2017 Dec;27(3):468-487

University of Maryland, Baltimore, MD, USA.

Background: Targeted temperature management (TTM) is often used in neurocritical care to minimize secondary neurologic injury and improve outcomes. TTM encompasses therapeutic hypothermia, controlled normothermia, and treatment of fever. TTM is best supported by evidence from neonatal hypoxic-ischemic encephalopathy and out-of-hospital cardiac arrest, although it has also been explored in ischemic stroke, traumatic brain injury, and intracranial hemorrhage patients. Read More

Int J Hyperthermia 2018 Nov 1;34(7):1010-1019. Epub 2017 Nov 1.

b Department of Medical Imaging , Jinan Military General Hospital , Jinan , China.

Purpose: To investigate the effect of head-cooling on resting-state spontaneous brain activity during passive hyperthermia.

Methods: An environmental heat exposure was simulated on 16 healthy men under a normal control condition (NC) at 25 °C and two hot conditions at 50 °C with hyperthermia with head-cooling condition (HHC) and without hyperthermia condition (HOT) keeping the head cool, respectively. Resting-state functional MRI (fMRI) data were acquired under each condition and the values of amplitude low frequency fluctuations (ALFF) and z functional connectivity (zFC) were computed to examine regional activity and functional integration, respectively. Read More

J Physiol 2017 12 25;595(24):7413-7426. Epub 2017 Oct 25.

Karolinska Institutet, Stockholm, Sweden.

Key Points: We investigated whether intramuscular temperature affects the acute recovery of exercise performance following fatigue-induced by endurance exercise. Mean power output was better preserved during an all-out arm-cycling exercise following a 2 h recovery period in which the upper arms were warmed to an intramuscular temperature of ̴ 38°C than when they were cooled to as low as 15°C, which suggested that recovery of exercise performance in humans is dependent on muscle temperature. Mechanisms underlying the temperature-dependent effect on recovery were studied in intact single mouse muscle fibres where we found that recovery of submaximal force and restoration of fatigue resistance was worsened by cooling (16-26°C) and improved by heating (36°C). Read More

Physiol Behav 2017 Dec 20;182:27-33. Epub 2017 Sep 20.

Department of Clinical Neuroscience, Division for Psychology, Karolinska Institutet, Nobels väg 9, 171 65 Solna, Stockholm, Sweden; Stress Research Institute, Stockholm University, Frescati Hagväg 16A, Stockholm 106 91, Sweden.

Yawning has been proposed to serve both physiological and social functions, the latter likely to have developed later in its evolution. A central hypothesis is that yawning cools the brain but whether yawning is a thermoregulatory mechanism that is activated during hyperthermia (i.e. Read More

J Biomed Mater Res B Appl Biomater 2018 Jul 15;106(5):1827-1841. Epub 2017 Sep 15.

College of Biology, Hunan University, Changsha, Hunan, 410082, China.

Magnetic hyperthermia has been rapidly developed as a potential cancer treatment in recent years. Artificially induced hyperthermia close to a tumor can raise the temperature to 45°C causing tumor cell death. Herein, we introduce a novel method for rapid preparation of anti-cancer magnetocaloric PCL/Fe O mats capable of high-performance hyperthermia using E-jet 3D printing technology. Read More

Mil Med 2017 09;182(9):e1951-e1957

Exercise Science Research Center, University of Arkansas, Department of Health, Human Performance and Recreation, HPER 321, 155 Stadium Drive, Fayetteville, AR 72701.

Background: The procedure of wrapping a heat casualty in ice-water soaked bed sheets to reduce core temperature has received little investigation, despite the practice and recommendation for its use in some military settings. Thus, the purpose of this study was to investigate the cooling efficacy of ice-sheet cooling (ISC) following exertional hyperthermia.

Methods: 13 (11 males, 2 females) participants (age = 23 ± 3 years, height = 176. Read More

J Med Case Rep 2017 Aug 25;11(1):247. Epub 2017 Aug 25.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie-Fang Road, Wuhan, 430030, China.

Background: Congenital insensitivity to pain with anhidrosis is a rare autosomal recessive disorder characterized by hyperpyrexia, anhidrosis, pain insensitivity, self-inflicted injuries, and intellectual disability. The anesthetic management of these patients is challenging owing to the high risk of perioperative complications resulting from their autonomic dysfunction, such as hyperthermia, hypotension, and bradycardia, which result from autonomic nervous system dysfunction.

Case Presentation: Two 3-year-old Han Chinese identical male twins (weighing 13. Read More

Theranostics 2017 7;7(10):2718-2731. Epub 2017 Jul 7.

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada.

The future of nanomedicines in oncology requires leveraging more than just the passive drug accumulation in tumors through the enhanced permeability and retention effect. Promising results combining mild hyperthermia (HT) with lyso-thermosensitive liposomal doxorubicin (LTSL-DOX) has led to improved drug delivery and potent antitumor effects in pre-clinical studies. The ultimate patient benefit from these treatments can only be realized when robust methods of HT can be achieved clinically. Read More

Ther Hypothermia Temp Manag 2017 Sep 16;7(3):118-121. Epub 2017 Aug 16.

4 Penrith Hospital , Cumbria Partnership NHS Foundation Trust, Cumbria, United Kingdom .

Ugeskr Laeger 2017 Jul;179(30)

Hyperthermia is an uncontrolled elevation of body temperature exceeding the body's ability to dissipate heat. Hyperthermia can result in dangerously high core temperatures and can rapidly become fatal. Common causes include heat stroke, malignant hyperthermia, serotonin syndrome, neuroleptic syndrome, a few endocrine emergencies as well as numerous intoxications. Read More

Biopreserv Biobank 2017 Oct 7;15(5):404-409. Epub 2017 Aug 7.

1 Department of Mechanical Engineering, University of Washington , Seattle, Washington.

In the rewarming process during cryopreservation, preventing ice recrystallization and thermal stress is important, especially for large tissues and organs. Uniform and rapid heating is essential in ameliorating the problem and maintaining the viability of cryopreserved biological samples. Currently, the most promising method is heating by application of electromagnetic (EM) waves, the effectiveness of which is dependent on the dielectric properties (DP) of the cryopreserved materials. Read More

Int J Hyperthermia 2018 06 16;34(4):382-391. Epub 2017 Aug 16.

b Department of Radiology , Hadassah Hebrew University, Medical Center , Jerusalem , Israel.

Purpose: To evaluate, characterise and compare the extent of tissue shrinkage induced from three different commercial microwave ablation devices, and to elucidate the mechanism behind the distinctive performances obtained.

Materials And Methods: Microwave ablation (N = 152) was conducted with three different commercial devices on cubes of ex vivo liver (10-40 ± 2 mm/side) embedded in agar phantoms. 50-60 W was applied for 1-10 min duration. Read More

Ther Hypothermia Temp Manag 2017 Dec 21;7(4):206-209. Epub 2017 Jul 21.

Department of Cardiovascular Disease, Icahn School of Medicine , Mount Sinai Beth Israel, New York, New York.

Rebound hyperthermia (RH) is frequently seen after completion of targeted temperature management (TTM) in comatose survivors of cardiac arrest. However, its clinical significance is not well understood. Previous studies analyzing the association of RH with clinical outcome have reported conflicting results. Read More

J Athl Train 2017 Aug 17;52(8):747-752. Epub 2017 Jul 17.

Central Michigan University, Mount Pleasant.

Context:   Cold-water immersion (CWI; 10°C) can effectively reduce body core temperature even if a hyperthermic human is wearing a full American football uniform (PADS) during treatment. Temperate-water immersion (TWI; 21°C) may be an effective alternative to CWI if resources for the latter (eg, ice) are unavailable.

Objective:   To measure rectal temperature (T) cooling rates, thermal sensation, and Environmental Symptoms Questionnaire (ESQ) scores of participants wearing PADS or shorts, undergarments, and socks (NO) before, during, and after TWI. Read More

Am J Emerg Med 2018 Jan 5;36(1):66-72. Epub 2017 Jul 5.

Department of Emergency Medicine, Singapore General Hospital, Singapore; Health Services and Systems Research, Duke-NUS Medical School, Singapore. Electronic address:

Background: Targeted temperature management post-cardiac arrest is currently implemented using various methods, broadly categorized as internal and external. This study aimed to evaluate survival-to-hospital discharge and neurological outcomes (Glasgow-Pittsburgh Score) of post-cardiac arrest patients undergoing internal cooling verses external cooling.

Methodology: A randomized controlled trial of post-resuscitation cardiac arrest patients was conducted from October 2008-September 2014. Read More

Lasers Med Sci 2017 Aug 22;32(6):1399-1409. Epub 2017 Jun 22.

Institut für Diagnostische und Interventionelle Radiologie, Theodor-Stern-Kai 7, Haus 23c, 60590, Frankfurt, Germany.

The purpose of the study was to develop a simulation approach for laser-induced thermotherapy (LITT) that is based on mathematical models for radiation transport, heat transport, and tissue damage. The LITT ablation was applied to ex vivo pig liver tissue. Experiments were repeated with different laser powers, i. Read More

Int J Hyperthermia 2018 06 26;34(4):352-362. Epub 2017 Jun 26.

d Department of Radiology and Imaging Sciences , University of Utah , Salt Lake City , UT , USA.

Purpose: This study investigates the feasibility of non-invasively determining thermal diffusivity (α) and the Pennes perfusion parameter (w) from pre-clinical and clinical magnetic resonance-guided focussed ultrasound (MRgFUS) temperature data.

Materials And Methods: Pre-clinical MRgFUS experiments were performed in rabbit muscle (N = 3, 28 sonications) using three-dimensional MR thermometry. Eight sonications were made in a clinical QA phantom with two-dimensional thermometry. Read More

Crit Care Med 2017 Jul;45(7):1152-1159

1Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.2Program in Trauma, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.3Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD.4Medicine and Research Services, Baltimore Veterans Affairs Medical Care System, Baltimore, MD.

Objectives: Prior studies suggest hypothermia may be beneficial in acute respiratory distress syndrome, but cooling causes shivering and increases metabolism. The objective of this study was to assess the feasibility of performing a randomized clinical trial of hypothermia in patients with acute respiratory distress syndrome receiving treatment with neuromuscular blockade because they cannot shiver.

Design: Retrospective study and pilot, prospective, open-label, feasibility study. Read More

Am J Physiol Regul Integr Comp Physiol 2017 06 12;312(6):R996-R1003. Epub 2017 Apr 12.

Department of Health Sciences, Faculty of Human Life and Environment, Nara Women's University, Nara, Japan;

We herein investigated the effects of face/head and whole body cooling during passive heat stress on human somatosensory processing recorded by somatosensory-evoked potentials (SEPs) at C4' and Fz electrodes. Fourteen healthy subjects received a median nerve stimulation at the left wrist. SEPs were recorded at normothermic baseline (Rest), when esophageal temperature had increased by ~1. Read More

Can Respir J 2017 12;2017:3087505. Epub 2017 Mar 12.

Psychological Department, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

. The study aimed to investigate the effectiveness of antipyretic therapy on mortality in critically ill patients with sepsis requiring mechanical ventilation. . Read More