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    579 results match your criteria Cooling Techniques for Hyperthermia

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    An effective thermal therapy against cancer using an E-jet 3D-printing method to prepare implantable magnetocaloric mats.
    J Biomed Mater Res B Appl Biomater 2017 Sep 15. Epub 2017 Sep 15.
    College of Biology, Hunan University, Changsha, Hunan, 410082, China.
    Magnetic hyperthermia has been rapidly developed as a potential cancer treatment in recent years. Artificially induced hyperthermia close to a tumor can raise the temperature to 45°C causing tumor cell death. Herein, we introduce a novel method for rapid preparation of anti-cancer magnetocaloric PCL/Fe3 O4 mats capable of high-performance hyperthermia using E-jet 3D printing technology. Read More

    Effectiveness of Ice-Sheet Cooling Following Exertional Hyperthermia.
    Mil Med 2017 Sep;182(9):e1951-e1957
    Exercise Science Research Center, University of Arkansas, Department of Health, Human Performance and Recreation, HPER 321, 155 Stadium Drive, Fayetteville, AR 72701.
    Background: The procedure of wrapping a heat casualty in ice-water soaked bed sheets to reduce core temperature has received little investigation, despite the practice and recommendation for its use in some military settings. Thus, the purpose of this study was to investigate the cooling efficacy of ice-sheet cooling (ISC) following exertional hyperthermia.

    Methods: 13 (11 males, 2 females) participants (age = 23 ± 3 years, height = 176. Read More

    Focused Ultrasound Hyperthermia Mediated Drug Delivery Using Thermosensitive Liposomes and Visualized With in vivo Two-Photon Microscopy.
    Theranostics 2017 7;7(10):2718-2731. Epub 2017 Jul 7.
    Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada.
    The future of nanomedicines in oncology requires leveraging more than just the passive drug accumulation in tumors through the enhanced permeability and retention effect. Promising results combining mild hyperthermia (HT) with lyso-thermosensitive liposomal doxorubicin (LTSL-DOX) has led to improved drug delivery and potent antitumor effects in pre-clinical studies. The ultimate patient benefit from these treatments can only be realized when robust methods of HT can be achieved clinically. Read More

    [Treatment of hyperthermia].
    Ugeskr Laeger 2017 Jul;179(30)
    Hyperthermia is an uncontrolled elevation of body temperature exceeding the body's ability to dissipate heat. Hyperthermia can result in dangerously high core temperatures and can rapidly become fatal. Common causes include heat stroke, malignant hyperthermia, serotonin syndrome, neuroleptic syndrome, a few endocrine emergencies as well as numerous intoxications. Read More

    Tissue shrinkage in microwave thermal ablation: comparison of three commercial devices.
    Int J Hyperthermia 2017 Aug 16:1-10. Epub 2017 Aug 16.
    b Department of Radiology , Hadassah Hebrew University, Medical Center , Jerusalem , Israel.
    Purpose: To evaluate, characterise and compare the extent of tissue shrinkage induced from three different commercial microwave ablation devices, and to elucidate the mechanism behind the distinctive performances obtained.

    Materials And Methods: Microwave ablation (N = 152) was conducted with three different commercial devices on cubes of ex vivo liver (10-40 ± 2 mm/side) embedded in agar phantoms. 50-60 W was applied for 1-10 min duration. Read More

    Randomized controlled trial of internal and external targeted temperature management methods in post- cardiac arrest patients.
    Am J Emerg Med 2017 Jul 5. Epub 2017 Jul 5.
    Department of Emergency Medicine, Singapore General Hospital, Singapore; Health Services and Systems Research, Duke-NUS Medical School, Singapore. Electronic address:
    Background: Targeted temperature management post-cardiac arrest is currently implemented using various methods, broadly categorized as internal and external. This study aimed to evaluate survival-to-hospital discharge and neurological outcomes (Glasgow-Pittsburgh Score) of post-cardiac arrest patients undergoing internal cooling verses external cooling.

    Methodology: A randomized controlled trial of post-resuscitation cardiac arrest patients was conducted from October 2008-September 2014. Read More

    Thermal diffusivity and perfusion constants from in vivo MR-guided focussed ultrasound treatments: a feasibility study.
    Int J Hyperthermia 2017 Jun 26:1-11. Epub 2017 Jun 26.
    d Department of Radiology and Imaging Sciences , University of Utah , Salt Lake City , UT , USA.
    Purpose: This study investigates the feasibility of non-invasively determining thermal diffusivity (α) and the Pennes perfusion parameter (w) from pre-clinical and clinical magnetic resonance-guided focussed ultrasound (MRgFUS) temperature data.

    Materials And Methods: Pre-clinical MRgFUS experiments were performed in rabbit muscle (N = 3, 28 sonications) using three-dimensional MR thermometry. Eight sonications were made in a clinical QA phantom with two-dimensional thermometry. Read More

    Pilot Feasibility Study of Therapeutic Hypothermia for Moderate to Severe Acute Respiratory Distress Syndrome.
    Crit Care Med 2017 Jul;45(7):1152-1159
    1Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.2Program in Trauma, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.3Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD.4Medicine and Research Services, Baltimore Veterans Affairs Medical Care System, Baltimore, MD.
    Objectives: Prior studies suggest hypothermia may be beneficial in acute respiratory distress syndrome, but cooling causes shivering and increases metabolism. The objective of this study was to assess the feasibility of performing a randomized clinical trial of hypothermia in patients with acute respiratory distress syndrome receiving treatment with neuromuscular blockade because they cannot shiver.

    Design: Retrospective study and pilot, prospective, open-label, feasibility study. Read More

    Effects of face/head and whole body cooling during passive heat stress on human somatosensory processing.
    Am J Physiol Regul Integr Comp Physiol 2017 Jun 12;312(6):R996-R1003. Epub 2017 Apr 12.
    Department of Health Sciences, Faculty of Human Life and Environment, Nara Women's University, Nara, Japan;
    We herein investigated the effects of face/head and whole body cooling during passive heat stress on human somatosensory processing recorded by somatosensory-evoked potentials (SEPs) at C4' and Fz electrodes. Fourteen healthy subjects received a median nerve stimulation at the left wrist. SEPs were recorded at normothermic baseline (Rest), when esophageal temperature had increased by ~1. Read More

    Effect of Antipyretic Therapy on Mortality in Critically Ill Patients with Sepsis Receiving Mechanical Ventilation Treatment.
    Can Respir J 2017 12;2017:3087505. Epub 2017 Mar 12.
    Psychological Department, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
    Purpose. The study aimed to investigate the effectiveness of antipyretic therapy on mortality in critically ill patients with sepsis requiring mechanical ventilation. Methods. Read More

    Malignant Hyperthermia Susceptibility and Fitness for Duty.
    Mil Med 2017 Mar;182(3):e1854-e1857
    Department of Anesthesiology and Pain Medicine, 8901 Wisconsin Avenue, Walter Reed National Military Medical Center, Bethesda, MD 20889-5600.
    Introduction: Malignant hyperthermia (MH) is an inherited hypermetabolic condition characterized by uncontrolled calcium release from the sarcoplasmic reticulum of skeletal muscle, usually from exposure to inhaled general anesthetics and/or the depolarizing neuromuscular blocking agent succinylcholine. Multiple case reports now reveal that crises may be precipitated by environmental factors such as exercise or high ambient temperatures. Common signs of an MH crisis include life-threatening hyperthermia, metabolic acidosis, muscle rigidity, and tachycardia. Read More

    The typical presentation of an atypical pathogen during an outbreak of Legionnaires' disease in Vila Franca de Xira, Portugal, 2014.
    Rev Port Pneumol (2006) 2017 May - Jun;23(3):117-123. Epub 2017 Mar 1.
    Chest Department, Centro Hospitalar Lisboa Norte, Lisboa, Portugal; Institute of Environmental Health (ISAMB), Faculty of Medicine, University of Lisbon, Lisboa, Portugal.
    Background: An outbreak of Legionella pneumophila serogroup 1, with 403 cases was identified on the 7th November 2014 in Vila Franca de Xira, Portugal. Outbreak source was the wet cooling system of a local factory. Hospital Pulido Valente was one of the hospitals receiving patients with Legionnaires' disease (LD). Read More

    Increased postural sway in persons with multiple sclerosis during short-term exposure to warm ambient temperatures.
    Gait Posture 2017 Mar 8;53:230-235. Epub 2017 Feb 8.
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital and UT Southwestern Medical Center, Dallas, TX, USA. Electronic address:
    Background: Multiple sclerosis (MS) is a neurological disease marked by demyelination and axonal loss. Individuals with MS experience increases in clinical signs and symptoms during heat exposure.

    Objective: To test the hypothesis that moderate heat exposure adversely affects postural sway in individuals with MS. Read More

    Protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial.
    Crit Care Resusc 2017 Mar;19(1):81-87
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
    Background: Body temperature can be reduced in febrile patients in the intensive care unit using medicines and physical cooling devices, but it is not known whether systematically preventing and treating fever reduces body temperature compared with standard care.

    Objective: To describe the study protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial.

    Design, Setting And Participants: Protocol for a phase II, multicentre trial to be conducted in Australian and New Zealand ICUs admitting adult patients. Read More

    Simple and effective method to lower body core temperatures of hyperthermic patients.
    Am J Emerg Med 2017 Jun 30;35(6):881-884. Epub 2017 Jan 30.
    CSA Medical, Inc., 91 Hartwell Avenue, Lexington, MA 02421, USA. Electronic address:
    Hyperthermia is a potentially life threatening scenario that may occur in patients due to accompanying morbidities, exertion, or exposure to dry and arid environmental conditions. In particular, heat stroke may result from environmental exposure combined with a lack of thermoregulation. Key clinical findings in the diagnosis of heatstroke are (1) a history of heat stress or exposure, (2) a rectal temperature greater than 40 °C, and (3) central nervous system dysfunction (altered mental state, disorientation, stupor, seizures, or coma) (Prendergast and Erickson, 2014 [1]). Read More

    Changing target temperature from 33°C to 36°C in the ICU management of out-of-hospital cardiac arrest: A before and after study.
    Resuscitation 2017 Apr 31;113:39-43. Epub 2017 Jan 31.
    Department of Epidemiology and Preventive Medicine, Monash University, Australia; The Alfred Hospital, Australia; Ambulance Victoria, Australia.
    Introduction: In December 2013, our institution changed the target temperature management (TTM) for the first 24h in ventricular fibrillation out-of-hospital cardiac arrest (VF-OHCA) patients from 33°C to 36°C. This study aimed to examine the impact this change had on measured temperatures and patient outcomes.

    Methods: We conducted a retrospective cohort study of consecutive VF-OHCA patients admitted to a tertiary referral hospital in Melbourne (Australia) between January 2013 and August 2015. Read More

    Visual function and retinal vessel diameters during hyperthermia in man.
    Acta Ophthalmol 2016 Dec 21. Epub 2016 Dec 21.
    Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
    Purpose: To assess the effect of elevated core body temperature on temporal and spatial contrast sensitivity and retinal vessel diameters.

    Methods: The study included 13 healthy volunteers aged 20-37 years. Core body temperature elevation (target +1. Read More

    CAERvest® - a novel endothermic hypothermic device for core temperature cooling: safety and efficacy testing.
    Int J Occup Saf Ergon 2017 Feb 2:1-11. Epub 2017 Feb 2.
    a Centre for Sport and Exercise Science and Medicine (SeSAME), Environmental Extremes Laboratory , University of Brighton , UK.
    Introduction: Cooling of the body is used to treat hyperthermic individuals with heatstroke or to depress core temperature below normal for neuroprotection. A novel, chemically activated, unpowered cooling device, CAERvest®, was investigated for safety and efficacy.

    Methods: Eight healthy male participants (body mass 79. Read More

    Comparison of Two Surface Cooling Devices for Temperature Management in a Neurocritical Care Unit.
    Ther Hypothermia Temp Manag 2017 Sep 13;7(3):147-151. Epub 2016 Dec 13.
    Department of Neurology, University of Missouri , Columbia, Missouri.
    Fever increases mortality and morbidity and length of stay in neurocritically ill patients. Various methods are used in the neuroscience intensive care unit (NSICU) to control fever. Two such methods involve the Arctic Sun hydrogel wraps and the Gaymar cooling wraps. Read More

    Physiological and perceptual effects of a cooling garment during simulated industrial work in the heat.
    Appl Ergon 2017 Mar 20;59(Pt A):442-448. Epub 2016 Oct 20.
    Human Performance Laboratory, University of Arkansas, 155 Stadium Dr HPER 321, Fayetteville, AR 72701, USA. Electronic address:
    Objective: Evaluate physiological and perceptual responses using a phase change cooling (PCC) garment during simulated work in the heat.

    Methods: Twenty males wearing compression undergarments, coverall suit, gloves, and hard-hat, completed two randomly assigned trials (with PCC inserts or control, CON) of simulated industrial tasks in the heat (34.2 ± 0. Read More

    Modeling of heat transfer in a vascular tissue-like medium during an interstitial hyperthermia process.
    J Therm Biol 2016 Dec 30;62(Pt B):150-158. Epub 2016 Jun 30.
    Department of Mechanical Engineering, Isfahan University of Technology, Isfahan, Iran.
    This paper aims to evaluate the role of small vessels in heat transfer mechanisms of a tissue-like medium during local intensive heating processes, for example, an interstitial hyperthermia treatment. To this purpose, a cylindrical tissue with two co- and counter-current vascular networks and a central heat source is introduced. Next, the energy equations of tissue, supply fluid (arterial blood), and return fluid (venous blood) are derived using porous media approach. Read More

    Cooling Effectiveness of a Modified Cold-Water Immersion Method After Exercise-Induced Hyperthermia.
    J Athl Train 2016 Nov 22;51(11):946-951. Epub 2016 Nov 22.
    University of Arkansas, Fayetteville.
    Context:  Recommended treatment for exertional heat stroke includes whole-body cold-water immersion (CWI). However, remote locations or monetary or spatial restrictions can challenge the feasibility of CWI. Thus, the development of a modified, portable CWI method would allow for optimal treatment of exertional heat stroke in the presence of these challenges. Read More

    Tarp-Assisted Cooling as a Method of Whole-Body Cooling in Hyperthermic Individuals.
    Ann Emerg Med 2017 Mar 16;69(3):347-352. Epub 2016 Nov 16.
    Korey Stringer Institute, University of Connecticut, Storrs, CT.
    Study Objective: We investigated the efficacy of tarp-assisted cooling as a body cooling modality.

    Methods: Participants exercised on a motorized treadmill in hot conditions (ambient temperature 39.5°C [103. Read More

    Why Fever Phobia Is Still Common?
    Iran Red Crescent Med J 2016 Aug 5;18(8):e23827. Epub 2016 Jun 5.
    Department of Pediatrics, Turgut Ozal University, Ankara, Turkey.
    Background: Fever is a reliable sign of illness, but it also evokes fear and anxiety. It is not the fever itself but the fear of possible complications and accompanying symptoms that is important for pediatricians and parents.

    Objectives: We aimed to investigate maternal understanding of fever, its potential consequences, and impacts on the treatment of children. Read More

    Existence and control of Legionella bacteria in building water systems: A review.
    J Occup Environ Hyg 2017 Feb;14(2):124-134
    a TRC Environmental , New York , New York.
    Legionellae are waterborne bacteria which are capable of causing potentially fatal Legionnaires' disease (LD), as well as Pontiac Fever. Public concern about Legionella exploded following the 1976 outbreak at the American Legion conference in Philadelphia, where 221 attendees contracted pneumonia and 34 died. Since that time, a variety of different control methods and strategies have been developed and implemented in an effort to eradicate Legionella from building water systems. Read More

    Extracorporeal photopheresis practice patterns: An international survey by the ASFA ECP subcommittee.
    J Clin Apher 2017 Aug 21;32(4):215-223. Epub 2016 Jul 21.
    Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital, Chicago, IL.
    Background: Although many apheresis centers offer extracorporeal photopheresis (ECP), little is known about current treatment practices.

    Methods: An electronic survey was distributed to assess ECP practice internationally.

    Results: Of 251 responses, 137 met criteria for analysis. Read More

    The vascular cooling effect in hepatic multipolar radiofrequency ablation leads to incomplete ablation ex vivo.
    Int J Hyperthermia 2016 Nov 11;32(7):749-56. Epub 2016 Jul 11.
    a Department of General, Visceral and Vascular Surgery , Charité - Campus Benjamin Franklin , Berlin ;
    Purpose: Major limitations of conventional RFA are vascular cooling effects. However, vascular cooling effects are supposed to be less pronounced in multipolar RFA. The objective of this ex vivo study was a systematic evaluation of the vascular cooling effects in multipolar RFA. Read More

    Thermal dysregulation in Prader-Willi syndrome: a potentially fatal complication in adolescence, not just in infancy.
    BMJ Case Rep 2016 Jun 29;2016. Epub 2016 Jun 29.
    Paediatric Intensive Care Unit, The Royal Belfast Hospital For Sick Children, Belfast, UK.
    A 13-year-old boy with a background of Prader-Willi syndrome (PWS) was admitted to the regional paediatric intensive care unit, with community-acquired pneumonia. Despite a week of intravenous antibiotics, resolution of inflammatory markers and resolving consolidation on radiograph, he remained feverish. Fever of unknown origin investigations were negative and he was diagnosed with central thermal dysregulation secondary to hypothalamic dysfunction in PWS. Read More

    Comparison of Gastrointestinal and Rectal Temperatures During Recovery After a Warm-Weather Road Race.
    J Athl Train 2016 May 17;51(5):382-8. Epub 2016 May 17.
    Korey Stringer Institute, Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs.
    Context: It has been well established that gastrointestinal temperature (TGI) tracks closely with rectal temperature (TREC) during exercise. However, the field use of TGI pills is still being examined, and little is known about how measurements obtained using these devices compare during recovery after exercise in warm weather.

    Objective: To compare TGI and TREC in runners who completed an 11. Read More

    Evaluation of advanced cooling therapy's esophageal cooling device for core temperature control.
    Expert Rev Med Devices 2016 May 15;13(5):423-33. Epub 2016 Apr 15.
    d Department of Emergency Medicine, Advocate Christ Medical Center , University of Illinois , Chicago, Oak Lawn , IL , USA.
    Managing core temperature is critical to patient outcomes in a wide range of clinical scenarios. Previous devices designed to perform temperature management required a trade-off between invasiveness and temperature modulation efficiency. The Esophageal Cooling Device, made by Advanced Cooling Therapy (Chicago, IL), was developed to optimize warming and cooling efficiency through an easy and low risk procedure that leverages heat transfer through convection and conduction. Read More

    Use of an Esophageal Heat Exchanger to Maintain Core Temperature during Burn Excisions and to Attenuate Pyrexia on the Burns Intensive Care Unit.
    Case Rep Anesthesiol 2016 25;2016:7306341. Epub 2016 Feb 25.
    Welsh Centre for Burns, Morriston Hospital, Swansea SA6 6NL, UK.
    Introduction. Burns patients are vulnerable to hyperthermia due to sepsis and SIRS and to hypothermia due to heat loss during excision surgery. Both states are associated with increased morbidity and mortality. Read More

    Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia.
    Sci Rep 2016 Mar 21;6:23430. Epub 2016 Mar 21.
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
    Therapeutic hypothermia (HT) is standard care for moderate and severe neonatal hypoxic-ischaemic encephalopathy (HIE), the leading cause of permanent brain injury in term newborns. However, the optimal temperature for HT is still unknown, and few preclinical studies have compared multiple HT treatment temperatures. Additionally, HT may not benefit infants with severe encephalopathy. Read More

    Intractable Central Hyperthermia in the Setting of Brainstem Hemorrhage.
    Ther Hypothermia Temp Manag 2016 Jun 16;6(2):98-101. Epub 2016 Mar 16.
    Department of Neurology, University of Texas Southwestern Medical Center , Dallas, Texas.
    Hyperthermia from a central cause is associated with increased morbidity and mortality. Dysfunction of brainstem thermoregulatory pathways may explain the intractable rise in temperature. Antipyretics, dantrolene, bromocriptine, and surface and intravascular cooling devices have been attempted for temperature control. Read More

    PRACTICAL ASPECTS OF THERAPEUTIC HYPOTHERMIA IN NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY--QUESTIONS AND ANSWERS. PART I. PROVIDING NEWBORN CARE BEFORE AND DURING TRANSFER TO THE REFERENCE CENTER.
    Dev Period Med 2015 Jul-Sep;19(3 Pt 1):247-53
    The first decade of the 21st century saw the worldwide spread of therapeutic hypothermia as a beneficial therapeutic procedure in neonates with hypoxic-ischemic encephalopathy. New guidelines for the resuscitation of newborns confirm that therapeutic hypothermia should be the standard method of treatment offered to neonates with acute perinatal hypoxia. The quality of care which an asphyxiated newborn receives during and immediately after resuscitation, as well as the mode of preparation for transport, can have a significant impact on improving the outcome, but it can also result in the deterioration of neonates treated with hypothermia. Read More

    Targeted Temperature Modulation in the Neuroscience Patient.
    Crit Care Nurs Clin North Am 2016 Mar;28(1):125-36
    Neuroscience Intensive Care Unit, Thomas Jefferson University Hospital, 111 South 11th Street, Gibbon Building, Room 9300, Philadelphia, PA 19107, USA.
    There are many approaches to and opportunities for implementing temperature modulation in critically ill patients, but barriers also exist. Conceptually, the process of cooling is rather straightforward; however, targeted temperature management is anything but simplistic. The need for a collaborative approach (physicians champions, nursing support, respiratory therapists, pharmacists, laboratory personnel, and supply chain representatives) to address definitions of normothermia and fever, patient inclusion/exclusion criteria for therapy based on underlying neurorelated pathologies, determination of methods of induction/maintenance, monitoring required, education planning, and strategies to minimize potential complications are warranted. Read More

    Prognostic factors associated with hospital survival in comatose survivors of cardiac arrest.
    World J Crit Care Med 2016 Feb 4;5(1):103-10. Epub 2016 Feb 4.
    Kushaharan Sathianathan, Critical Care Unit, Latrobe Regional Hospital, Traralgon, VIC 3844, Australia.
    Aim: To identify patient, cardiac arrest and management factors associated with hospital survival in comatose survivors of cardiac arrest.

    Methods: A retrospective, single centre study of comatose patients admitted to our intensive care unit (ICU) following cardiac arrest during the twenty year period between 1993 and 2012. This study was deemed by the Human Research Ethics Committee (HREC) of Monash Health to be a quality assurance exercise, and thus did not require submission to the Monash Health HREC (Research Project Application, No. Read More

    Effects of mild hypohydration on cooling during cold-water immersion following exertional hyperthermia.
    Eur J Appl Physiol 2016 Apr 18;116(4):687-95. Epub 2016 Jan 18.
    University of Arkansas, 155 Stadium Dr HPER 321, Fayetteville, AR, 72701, USA.
    Purpose: We investigated the effects of mild hypohydration compared to euhydration on the cooling efficacy of cold-water immersion (CWI).

    Methods: Fourteen participants (eight male, six female; age 26 ± 5 years; ht 1.77 ± 0. Read More

    Changes in cardiac arrest patients' temperature management after the 2013 "TTM" trial: results from an international survey.
    Ann Intensive Care 2016 Dec 12;6(1). Epub 2016 Jan 12.
    Medical-surgical intensive care unit, Saint Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
    Background: Therapeutic hypothermia (TH between 32 and 34 °C) was recommended until recently in unconscious successfully resuscitated cardiac arrest (CA) patients, especially after initial shockable rhythm. A randomized controlled trial published in 2013 observed similar outcome between a 36 °C-targeted temperature management (TTM) and a 33 °C-TTM. The main aim of our study was to assess the impact of this publication on physicians regarding their TTM practical changes. Read More

    Therapeutic hypothermia and targeted temperature management in traumatic brain injury: Clinical challenges for successful translation.
    Brain Res 2016 Jun 30;1640(Pt A):94-103. Epub 2015 Dec 30.
    Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States.
    The use of therapeutic hypothermia (TH) and targeted temperature management (TTM) for severe traumatic brain injury (TBI) has been tested in a variety of preclinical and clinical situations. Early preclinical studies showed that mild reductions in brain temperature after moderate to severe TBI improved histopathological outcomes and reduced neurological deficits. Investigative studies have also reported that reductions in post-traumatic temperature attenuated multiple secondary injury mechanisms including excitotoxicity, free radical generation, apoptotic cell death, and inflammation. Read More

    The Effect of Paracetamol on Core Body Temperature in Acute Traumatic Brain Injury: A Randomised, Controlled Clinical Trial.
    PLoS One 2015 17;10(12):e0144740. Epub 2015 Dec 17.
    Division of Critical Care and Trauma Division, The George Institute for Global Health, Sydney, New South Wales, Australia.
    Background: Strategies to prevent pyrexia in patients with acute neurological injury may reduce secondary neuronal damage. The aim of this study was to determine the safety and efficacy of the routine administration of 6 grams/day of intravenous paracetamol in reducing body temperature following severe traumatic brain injury, compared to placebo.

    Methods: A multicentre, randomised, blind, placebo-controlled clinical trial in adult patients with traumatic brain injury (TBI). Read More

    Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury.
    World J Crit Care Med 2015 Nov 4;4(4):296-301. Epub 2015 Nov 4.
    Kristine H O'Phelan, Amedeo Merenda, Departments of Neurology and Neurosurgery, University of Miami, Miami, FL 33136, United States.
    Aim: To examine complications associated with the use of therapeutic temperature modulation (mild hypothermia and normothermia) in patients with severe traumatic brain injury (TBI).

    Methods: One hundred and fourteen charts were reviewed. Inclusion criteria were: severe TBI with Glasgow Coma Scale (GCS) < 9, intensive care unit (ICU) stay > 24 h and non-penetrating TBI. Read More

    Localised hyperthermia in rodent models using an MRI-compatible high-intensity focused ultrasound system.
    Int J Hyperthermia 2015 5;31(8):813-22. Epub 2015 Nov 5.
    a Department of Radiology , University of Texas Southwestern Medical Center , Dallas , Texas .
    Purpose: Localised hyperthermia in rodent studies is challenging due to the small target size. This study describes the development and characterisation of an MRI-compatible high-intensity focused ultrasound (HIFU) system to perform localised mild hyperthermia treatments in rodent models.

    Material And Methods: The hyperthermia platform consisted of an MRI-compatible small animal HIFU system, focused transducers with sector-vortex lenses, a custom-made receive coil, and means to maintain systemic temperatures of rodents. Read More

    Characteristics of laparoscopic microwave ablation with renal tissue: Experimental in vivo study using a porcine model.
    Int J Hyperthermia 2015 2;31(8):930-6. Epub 2015 Nov 2.
    b Department of Urology , Beijing Chaoyang Hospital, Capital Medical University , Beijing .
    Purpose: A model of in vivo porcine kidneys is used to clarify the characteristics of laparoscopic microwave ablation (MWA) of renal tissue.

    Materials And Methods: Six pigs were utilised for the experiment using 18G water circulating-cooling microwave needles. The operating frequency was 2450 MHz, and the independent variables were power (50-60 W) and time (300-600 s). Read More

    Fever phobia: a comparison survey between caregivers in the inpatient ward and caregivers at the outpatient department in a children's hospital in China.
    BMC Pediatr 2015 Oct 19;15:163. Epub 2015 Oct 19.
    Department of Pediatric, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, Zhejiang Province, 325027, China.
    Background: Fever in children is one of the most common clinical symptoms and a chief complaint and a main reason that caregivers took the children to the outpatient service or admitted to hospital. Studies have found that the majority of parents surveyed at a hospital pediatric clinic held unrealistic and unwarranted concerns about fevers, first termed as 'fever phobia' by Schmitt in 1980. In the present study, we explore whether 'fever phobia' exists in Chinese caregivers and investigate whether such phobia is alleviated when admitted to hospital after propaganda of fever related knowledge by doctors and nurses. Read More

    Temperature control in critically ill patients with a novel esophageal cooling device: a case series.
    BMC Anesthesiol 2015 Oct 19;15:152. Epub 2015 Oct 19.
    Department of Medicine, Division of Critical Care, University of Western Ontario, London Health Sciences Centre, University Hospital, 339 Windermere Road, London, N6A 5A5, ON, Canada.
    Background: Mild hypothermia and fever control have been shown to improve neurological outcomes post cardiac arrest. Common methods to induce hypothermia include body surface cooling and intravascular cooling; however, a new approach using an esophageal cooling catheter has recently become available.

    Methods: We report the first three cases of temperature control using an esophageal cooling device (ECD). Read More

    Inotropic Effects of Experimental Hyperthermia and Hypothermia on Left Ventricular Function in Pigs-Comparison With Dobutamine.
    Crit Care Med 2016 Mar;44(3):e158-67
    1Department of Cardiology, Medical University of Graz, Graz, Austria.2Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, Germany.3Department of Cardiothoracic Surgery, Medical University of Graz, Graz, Austria.4Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.5Department of Cardiology, Charité Berlin Campus Virchow, Berlin, Germany.
    Objectives: The results from the recent Targeted Temperature Management trial raised the question whether cooling or merely the avoidance of fever mediates better neurologic outcome in resuscitated patients. As temperature per se is a major determinant of cardiac function, we characterized the effects of hyperthermia (40.5°C), normothermia (38. Read More

    T1 and T2 temperature dependence of female human breast adipose tissue at 1.5 T: groundwork for monitoring thermal therapies in the breast.
    NMR Biomed 2015 Nov 24;28(11):1463-70. Epub 2015 Sep 24.
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.
    The T1 and T2 temperature dependence of female breast adipose tissue was investigated at 1.5 T in order to evaluate the applicability of relaxation-based MR thermometry in fat for the monitoring of thermal therapies in the breast. Relaxation times T1 , T2 and T2TSE (the apparent T2 measured using a turbo spin echo readout sequence) were measured in seven fresh adipose breast samples for temperatures from 25 to 65 °C. Read More

    Greater temperature variability is not associated with a worse neurological outcome after cardiac arrest.
    Resuscitation 2015 Nov 16;96:268-74. Epub 2015 Sep 16.
    Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik, 808, 1070 Brussels, Belgium. Electronic address:
    Aim: Spontaneous alterations in temperature homeostasis after cardiac arrest (CA) are associated with worse outcome. However, it remains unclear the prognostic role of temperature variability (TV) during cooling procedures. We hypothesized that low TV during targeted temperature management (TTM) would be associated with a favourable neurological outcome after CA. Read More

    An ethnobotanical survey of medicinal plants in Trinidad.
    J Ethnobiol Ethnomed 2015 Sep 15;11:67. Epub 2015 Sep 15.
    Herbal Institute, The University of Trinidad and Tobago, St. Augustine, Trinidad and Tobago.
    Background: An ethnobotanical survey was conducted on the Caribbean island of Trinidad to identify medicinal plants commonly used in traditional medicine to treat a variety of medical conditions.

    Methods: A pilot survey was conducted to identify the top ten most common ailments where medicinal plants were used. The results of the foregoing study guided a wider national survey conducted between October 2007 and July 2008. Read More

    Baseline Evaluation With a Sweating Thermal Manikin of Personal Protective Ensembles Recommended for Use in West Africa.
    Disaster Med Public Health Prep 2015 Oct 28;9(5):536-42. Epub 2015 Aug 28.
    National Personal Protective Technology Laboratory of the National Institute for Occupational Safety and Health,Pittsburgh,Pennsylvania.
    Objective: Experience with the use of personal protective equipment (PPE) ensembles by health care workers responding to the Ebola outbreak in the hot, humid conditions of West Africa has prompted reports of significant issues with heat stress that has resulted in shortened work periods.

    Methods: A sweating thermal manikin was used to ascertain the time to achievement of a critical core temperature of 39 °C while wearing 4 different PPE ensembles similar to those recommended by the World Health Organization and Médecins Sans Frontières (Doctors Without Borders) at 2 different ambient conditions (32 °C/92% relative humidity and 26 °C/80% relative humidity) compared with a control ensemble.

    Results: PPE ensembles that utilized coveralls with moderate to high degrees of impermeability attained the critical core temperature in significantly shorter times than did other ensembles. Read More

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