Search Our Scientific Publications & Authors

J Dent Sci 2018 Sep 7;13(3):263-266. Epub 2018 Jun 7.

Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC.

Background/purpose: It was found that body temperature would be gradually increased during pediatric full mouth rehabilitation surgery. Although the etiology is unknown, here, we introduced an effective method to maintain normothermia during this kind of surgery.

Materials And Methods: Following IRB approval, the medical records of pediatric patients who received full mouth rehabilitation surgery from Jan. Read More

Int J Sports Physiol Perform 2019 Mar 6:1-20. Epub 2019 Mar 6.

6 Qatar University, Sport Science Program, College of Arts and Science, Doha, Qatar.

Purpose:: Determine how a cooling vest worn during a warm-up could influence selected performance [counter movement jump (CMJ)], physical (GPS metrics) and psycho-physiological (body temperature and perceptual) variables.

Methods:: In a randomized crossover design, twelve elite male World Rugby Sevens Series athletes completed an outdoor (WBGT: 23-27°C) match-specific externally-valid 30 min warm-up wearing a phase change cooling vest (VEST) and without (CONTROL), on separate occasions 7 days apart. CMJ was assessed before and after the warm-up, with GPS indices and heart rate monitored during the warm-ups, whilst core temperature (Tc; ingestible telemetric pill; n = 6) was recorded throughout the experimental period. Read More

Phytomedicine 2018 Dec 31:152815. Epub 2018 Dec 31.

Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, China; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. Electronic address:

Background: According to traditional Chinese medicine (TCM) theory, the herbal property is the most important guiding principle of ancient medication in China. The classification of warm- and cold-stimulating TCM is defined mainly based on the effects of herbs in regulating body temperature; however, the underlying mechanism of such distinction has not been fully identified.

Methods: Here, four commonly used spleen-meridian herbs, Ginseng Radix and Astragali Radix as typical warm-stimulating herbs, and Nelumbinis Semen and Coicis Semen as typical cold-stimulating herbs, were selected to test their effects in regulating body temperature, as well as its triggered thermo-regulatory factors and energy related metabolites, in yeast-induced fever rats. Read More

Top Spinal Cord Inj Rehabil 2019 ;25(1):74-82

Audie L. Murphy VA, San Antonio, Texas.

Decentralization of the sympathetic nervous system in persons with spinal cord injury (SCI) results in impaired vasomotor and sudomotor activity and, subsequently, impaired thermoregulatory capacity during exercise in the heat. Hyperthermia can be life-threatening and, as such, cooling interventions are needed to prevent this sequela. To measure change in core temperature (ΔT) over time during exercise in normothermic and high ambient heat conditions to compare thermoregulatory capacity in persons with varying degrees of intact vasomotor and sudomotor activity and to determine the efficacy of three cooling interventions in mitigating T rise. Read More

Lasers Med Sci 2019 Feb 14. Epub 2019 Feb 14.

Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991.

To improve methods of laser hyperthermia for the treatment of bulk malignant neoplasms, an urgent task is the development of techniques and devices that automatically control heating at a given tissue depth and ensure its uniformity. The article proposes the concept of a system for performing hyperthermia with real-time spectroscopic temperature control and surface cooling, which allows to record spectra of diffusely scattered radiation and fluorescent signal from various depths of biological tissues by the means of the variation of the angle and distance between the fiber source of laser radiation and the receiving fiber. Theoretical and experimental modeling of the spatial distribution of diffusely scattered radiation and temperature inside the tissue with a fiber optic device providing surface cooling of the irradiated tissue, and recording spectral information from a given depth in real time, is presented. Read More

Intensive Care Med 2019 Feb 11. Epub 2019 Feb 11.

University of Otago, Wellington, New Zealand.

Purpose: One potential way to protect patients from the physiological demands that are a consequence of fever is to aim to prevent fever and to treat it assiduously when it occurs. Our primary hypothesis was that more active fever management would increase survival among patient subgroups with limited physiological reserves such as older patients, patients with higher illness acuity, and those requiring organ support.

Methods: We conducted an individual-level patient data meta-analysis of randomised controlled trials to compare the outcomes of ICU patients who received more active fever management with the outcomes of patients who received less active fever management. Read More

Ther Hypothermia Temp Manag 2019 Jan 18. Epub 2019 Jan 18.

4 Department of Emergency Medicine, Southwestern Medical Centre, The University of Texas, Dallas, Texas.

Traumatic brain injury (TBI) is a leading cause of death in the United States, and represents 2.5 million Emergency Department attendances, admissions into hospital, and deaths. A range of temperature modulating devices have been used to proactively cool TBI patients; however, there are currently no uniform targeted temperature management (TTM) guidelines in this patient population. Read More

Aerosp Med Hum Perform 2019 Jan;90(1):12-17

Precooling (PC) before exercise may help prevent severe hyperthermia and exertional heatstroke (EHS). Before clinicians can advocate PC as an EHS prevention strategy, it must effectively mitigate factors associated with EHS development while not lessening the effectiveness of EHS treatment. Therefore, this study determined if PC affected rectal temperature (T), body heat storage, heart rate (HR), ratings of perceived exertion (RPE), thermal sensation, sweat rate, and postexercise cold-water immersion (CWI) T cooling rates. Read More

Pediatr Crit Care Med 2019 Feb;20(2):e77-e82

PICU, Hospital General Universitario Gregorio Marañon, Universidad Complutense de Madrid, Maternal and Child Health and Development Network (Red SAMID), Madrid, Spain.

Objectives: It is currently recommended that after return of spontaneous circulation following cardiac arrest, fever should be prevented using TTM through a servo-controlled system. This technology is not yet available in many global settings, where manual physical measures without servo-control is the only option. Our aim was to compare feasibility, safety and quality assurance of servo-controlled system versus no servo-controlled system cooling, TTM protocols for cooling, maintenance and rewarming following return of spontaneous circulation after cardiac arrest in children. Read More

J Therm Biol 2018 Dec 1;78:329-342. Epub 2018 Nov 1.

Department of Mechanical Engineering, NIT Arunachal Pradesh, Yupia 791112, India. Electronic address:

Attaining a precise necrosis of tumor sparing normal tissue during carcinomas thermo-therapy via nominally invasive scheme like irradiation of laser is a recent challenge. In this study, a combined diffusion and convective energy equations were solved using COMSOL Multiphysics to predict the tissue thermal profile during laser assisted thermo-therapy with different tissue vascular networks. A comparative analysis between intratumoral and intravenous loading scheme of silica-gold nanoshells (AuNs) was also performed. Read More

Int J Hyperthermia 2019 28;36(1):75-86. Epub 2018 Nov 28.

d Department of Information Engineering , University of Florence , Firenze , Italy.

Purpose: Bleeding from parenchyma transection during a robotic hepatic surgery remains the most critical point affecting postoperative recovery and long-term survival. Various robotic devices with different types of energies have been proposed; however, each of these lack in steerability, efficacy, or accuracy. The aim of this work is to evaluate the feasibility and performance of a new steerable microwave resection device intended for minimizing intraoperative blood loss during laparoscopic and robotic liver resections. Read More

Resuscitation 2019 Jan 22;134:49-54. Epub 2018 Oct 22.

Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Purpose: Early initiation of hypothermia is recommended in the setting of cardiac arrest. Current hypothermia methods are invasive and expensive and not applicable in ambulatory settings. We investigated the evaporative cooling effect of high flow transnasal dry air on core esophageal temperature in human volunteers. Read More

Eur J Sport Sci 2018 Oct 10:1-10. Epub 2018 Oct 10.

f School of Health and Human Sciences , Southern Cross University , Coffs Harbour , Australia.

Purpose: To characterize player core temperature (Tc) across two separate World Rugby Sevens Series (WRSS) tournaments in temperate and warm environments.

Methods: Tc was collected in seventeen playing members of one men's team competing at the Singapore (n = 12) and London (n = 11) WRSS tournaments. Exertional heat illness (EHI) symptoms, cooling strategy use, playing minutes and wet blub globe temperature (WBGT) were also collected. Read More

J Ther Ultrasound 2018 13;6. Epub 2018 Aug 13.

1Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, Box 0946, San Francisco, CA 94107 USA.

Background: Hyperthermia therapy (HT) has shown to be an effective adjuvant to radiation, chemotherapy, and immunotherapy. In order to be safe and effective, delivery of HT requires maintenance of target tissue temperature within a narrow range (40-44 °C) for 30-60 min, which necessitates conformal heat delivery and accurate temperature monitoring. The goal of this project was to develop an MR thermometry-guided hyperthermia delivery platform based upon the ExAblate prostate array that would achieve uniform stable heating over large volumes within the prostate, while allowing the user to precisely control the power deposition patterns and shape of the region of treatment (ROT). Read More

Neurocrit Care 2019 Feb;30(1):149-156

UniversitatsSpital Zurich, Zurich, Switzerland.

Background: Fever control plays a key role in therapy of patients with acute brain injury. The infusion of cold saline could serve as an alternative or additional method for targeted temperature management. However, it is difficult to estimate the amount of fluid required to achieve normothermia merely on the basis of body weight. Read More

Ther Hypothermia Temp Manag 2018 09 10;8(3):126-130. Epub 2018 Aug 10.

4 Department of Surgery, Harborview Center for Prehospital Emergency Care , Seattle, Washington.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Anaesthesia and Intensive Care, Mater Dei Hospital, Msida, Malta.

A 31-year-old man was brought to Accident & Emergency after collapsing during a race. On presentation, the patient had a temperature of 41.7°C (rectal). Read More

Int J Hyperthermia 2018 28;35(1):44-55. Epub 2018 May 28.

a Institute for Critical Technology and Applied Science, Virginia Tech , Blacksburg , VA , USA.

Purpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and temperature changes using a perfused porcine liver model.

Materials And Methods: A bipolar electrode delivered IRE electric pulses with or without activation of internal cooling to nine porcine mechanically perfused livers. Pulse schemes included a constant voltage, and a preconditioned delivery combined with an arc-mitigation algorithm. Read More

J Therm Biol 2018 May 26;74:264-274. Epub 2018 Apr 26.

School of Energy Science and Engineering, Harbin Institute of Technology, Harbin 150001, PR China. Electronic address:

Thermal therapy is a very promising method for cancer treatment, which can be combined with chemotherapy, radiotherapy and other programs for enhanced cancer treatment. In order to get a better effect of thermal therapy in clinical applications, optimal internal temperature distribution of the tissue embedded with gold nanoparticles (GNPs) for enhanced thermal therapy was investigated in present research. The Monte Carlo method was applied to calculate the heat generation of the tissue embedded with GNPs irradiated by continuous laser. Read More

Respir Investig 2018 Jul 10;56(4):356-360. Epub 2018 May 10.

Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. Electronic address:

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high diagnostic yield in lesions adjacent to the airways. However, complications associated with EBUS-TBNA, such as mediastinitis, have recently been reported. Oral bacteria contamination in punctured lymph nodes can cause severe infections. Read More

Pacing Clin Electrophysiol 2018 Apr 16. Epub 2018 Apr 16.

Department of Cardiology, Medical University of Graz, Graz, Austria.

Objective: Application of therapeutic mild hypothermia in patients after resuscitation, often accompanied by myocardial infarction, cardiogenic shock, and systemic inflammation may impact on cardiac rhythm. We therefore tested susceptibility to atrial arrhythmias during hyperthermia (HT, 40.5°C), normothermia (NT, 38. Read More

Crit Care 2018 Apr 13;22(1):90. Epub 2018 Apr 13.

Department of Intensive Care and Erasmus MC Stroke Center, Erasmus Medical Center, Rotterdam, the Netherlands.

Background: General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess and quantify variation in perceptions on intensive care unit (ICU) management of patients with TBI in European neurotrauma centers.

Methods: We performed a survey as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Read More

PLoS One 2018 29;13(3):e0195219. Epub 2018 Mar 29.

Department of Kinesiology, Brock University, St. Catharines, Ontario, Canada.

The large body of work demonstrating hyperthermic impairment of neuromuscular function has utilized maximal isometric contractions, but extrapolating these findings to whole-body exercise and submaximal, dynamic contractions may be problematic. We isolated and compared core and skin temperature influences on an isometric force task versus a position task requiring dynamic maintenance of joint angle. Surface electromyography (sEMG) was measured on the flexor carpi radialis at 60% of baseline maximal voluntary contraction while either pushing against a rigid restraint (force task) or while maintaining a constant wrist angle and supporting an equivalent inertial load (position task). Read More

Appl Physiol Nutr Metab 2018 Aug 12;43(8):857-860. Epub 2018 Mar 12.

c Human and Environmental Physiological Research Unit, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

We examined if physical characteristics could be used to predict cooling time during cold water immersion (CWI, 2 °C) following exertional hyperthermia (rectal temperature ≥39.5 °C) in a physically heterogeneous group of men and women (n = 62). Lean body mass was the only significant predictor of cooling time following CWI (R = 0. Read More

JBI Database System Rev Implement Rep 2018 Mar;16(3):791-801

School of Nursing, Fudan University, Shanghai, P.R. China.

Objectives: The aim of this evidence implementation project was to integrate the best available evidence on non-pharmacological fever and febrile symptom management into nursing practice at the Shanghai Public Health Clinical Centre, China.

Introduction: Fever is challenging for patients with the human immunodeficiency virus (HIV). Guidelines assert that successful non-pharmacological fever management should be the standard of care. Read More

Br J Nutr 2018 02;119(4):381-390

3Department of Food Hygiene and Quality Control, Veterinary Science Faculty,Bu-Ali Sina University,Hamedan, 65178-38695,Iran.

Strenuous physical exercise and hyperthermia may paradoxically induce oxidative stress and adverse effects on myocardial function. The purpose of this study was to investigate the effect of 14-d coenzyme Q10 (CoQ10) supplementation and pre-cooling on serum creatine kinase-MB (CK-MB), cardiac Troponin I (cTnI), myoglobin (Mb), lactate dehydrogenase (LD), total antioxidant capacity (TAC), lipid peroxidation (LPO) and CoQ10 concentration in elite swimmers. In total, thirty-six healthy males (mean age 17 (sd 1) years) were randomly selected and divided into four groups of supplementation, supplementation with pre-cooling, pre-cooling and control. Read More

Indian J Crit Care Med 2018 Jan;22(1):43-45

Post-Graduate Institute of Neurological Surgery, Dr. Achanta Lakshmipathi Neurosurgical Centre, Voluntary Health Services Multi-speciality Hospital and Research Centre, Chennai, Tamil Nadu, India.

Hyperpyrexia is a rare and at times fatal condition seen in an Intensive Care Unit setup. We encountered a case of a 65-year-old patient with road traffic accident presenting with dorsal spine fracture at D level. He underwent decompression and fusion for the same. Read More

Exp Physiol 2018 04 28;103(4):512-522. Epub 2018 Feb 28.

Centre for Human and Applied Physiology, School of Medicine, University of Wollongong, Wollongong, NSW, 2522, Australia.

New Findings: What is the central question of this study? Does the cold-water immersion (14°C) of profoundly hyperthermic individuals induce reductions in cutaneous and limb blood flow of sufficient magnitude to impair heat loss relative to the size of the thermal gradient? What is the main finding and its importance? The temperate-water cooling (26°C) of profoundly hyperthermic individuals was found to be rapid and reproducible. A vascular mechanism accounted for that outcome, with temperature-dependent differences in cutaneous and limb blood flows observed during cooling. Decisions relating to cooling strategies must be based upon deep-body temperature measurements that have response dynamics consistent with the urgency for cooling. Read More

J Vis Exp 2017 11 21(129). Epub 2017 Nov 21.

Attune Medical; Department of Emergency Medicine, University of Texas, Southwestern Medical Center;

Controlling patient temperature is important for a wide variety of clinical conditions. Cooling to normal or below normal body temperature is often performed for neuroprotection after ischemic insult (e.g. Read More

Ann Phys Rehabil Med 2018 Mar 11;61(2):72-77. Epub 2017 Dec 11.

School of Health Professions, Faculty of Health and Human Sciences, Plymouth University, Peninsula Allied Health Centre, Derriford Road, Plymouth, PL6 8BH, United Kingdom.

Objectives: Cooling of the lower limb in people with Hereditary and Spontaneous Spastic Paraparesis (pwHSSP) has been shown to affect walking speed and neuromuscular impairments. The investigation of practical strategies, which may help to alleviate these problems is important. The potential of superficial heat to improve walking speed has not been explored in pwHSSP. Read More

Ann Vasc Surg 2018 Apr 5;48:67-74. Epub 2017 Dec 5.

Department of Surgical Specialties, Tokyo Medical and Dental University, Tokyo, Japan.

Background: We previously reported the utility of the perfusion value (PV) fluctuation slope for detecting severe ischemia in the lower limb. Our approach was based on a thermal load test mimicking the well-known physiological reaction termed "cold-induced vasodilation," which is known to occur as a 3-phase phenomenon. The slope parameter quantifies the decrease in PVs accompanying the relative cooling (third phase) following the transient increase in blood flow (second phase) induced by the applied thermal load. Read More

J Neurosurg Pediatr 2018 02 1;21(2):164-170. Epub 2017 Dec 1.

1Division of Critical Care and.

OBJECTIVE Severe traumatic brain injury remains a leading cause of morbidity and mortality in the pediatric population. Providers focus on reducing secondary brain injury by avoiding hypoxemia, avoiding hypotension, providing normoventilation, treating intracranial hypertension, and reducing cerebral metabolic demand. Hyperthermia is frequently present in patients with severe traumatic brain injury, contributes to cerebral metabolic demand, and is associated with prolonged hospital admission as well as impaired neurological outcome. Read More

Eur Heart J Acute Cardiovasc Care 2018 Aug 27;7(5):467-477. Epub 2017 Nov 27.

3 Division of Cardiology, University of British Columbia, Canada.

Aims: The purpose of this study was to conduct a systematic review, and where applicable meta-analyses, examining the evidence underpinning the use of targeted temperature management following resuscitation from cardiac arrest.

Methods And Results: Multiple databases were searched for publications between January 2000-February 2016. Nine Population, Intervention, Comparison, Outcome questions were developed and meta-analyses were performed when appropriate. Read More

Eur Rev Med Pharmacol Sci 2017 Oct;21(4 Suppl):50-53

Department of Neonatology, Xunzhou Children's Hospital, Xuzhou, Jiangsu, China.

Neonatal hypoxic-ischemic encephalopathy (HIE) significantly affects neurodevelopment in infants and is also considered as an important cause of neonatal deaths worldwide. Medical research is being focused worldwide for the development of therapeutic avenues but it is still managed by supportive care. The latest studies in the above field have shown the efficacy of prolonged cooling of neonate's head or whole body at the age of 18 months (approx. Read More

Rev Cardiovasc Med 2017 ;18(3):115-122

Department of Cardiovascular Medicine, Beaumont Health, Royal Oak, MI.

Atrioesophageal fistula (AEF) is a rare but catastrophic complication of catheter ablation of atrial fibrillation (AF), with an incidence of 0.03% to 1.5% per year. Read More

J Anaesthesiol Clin Pharmacol 2017 Jul-Sep;33(3):306-316

Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

Administration of general anesthesia requires continuous monitoring of vital parameters of the body including body temperature. However, temperature continues to be one of the least seriously monitored parameters perioperatively. Inadvertent perioperative hypothermia is a relatively common occurrence with both general and regional anesthesia and can have significant adverse impact on patients' outcome. Read More

Eur J Appl Physiol 2018 Jan 28;118(1):101-109. Epub 2017 Oct 28.

Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.

Purpose: To determine the impact of local muscle heating and cooling on myogenic and proteolytic gene responses following resistance exercise.

Methods: Recreationally trained males (n = 12), age 25.3 ± 1. Read More

Neurocrit Care 2017 Dec;27(3):468-487

University of Maryland, Baltimore, MD, USA.

Background: Targeted temperature management (TTM) is often used in neurocritical care to minimize secondary neurologic injury and improve outcomes. TTM encompasses therapeutic hypothermia, controlled normothermia, and treatment of fever. TTM is best supported by evidence from neonatal hypoxic-ischemic encephalopathy and out-of-hospital cardiac arrest, although it has also been explored in ischemic stroke, traumatic brain injury, and intracranial hemorrhage patients. Read More

Int J Hyperthermia 2018 11 1;34(7):1010-1019. Epub 2017 Nov 1.

b Department of Medical Imaging , Jinan Military General Hospital , Jinan , China.

Purpose: To investigate the effect of head-cooling on resting-state spontaneous brain activity during passive hyperthermia.

Methods: An environmental heat exposure was simulated on 16 healthy men under a normal control condition (NC) at 25 °C and two hot conditions at 50 °C with hyperthermia with head-cooling condition (HHC) and without hyperthermia condition (HOT) keeping the head cool, respectively. Resting-state functional MRI (fMRI) data were acquired under each condition and the values of amplitude low frequency fluctuations (ALFF) and z functional connectivity (zFC) were computed to examine regional activity and functional integration, respectively. Read More

J Physiol 2017 12 25;595(24):7413-7426. Epub 2017 Oct 25.

Karolinska Institutet, Stockholm, Sweden.

Key Points: We investigated whether intramuscular temperature affects the acute recovery of exercise performance following fatigue-induced by endurance exercise. Mean power output was better preserved during an all-out arm-cycling exercise following a 2 h recovery period in which the upper arms were warmed to an intramuscular temperature of ̴ 38°C than when they were cooled to as low as 15°C, which suggested that recovery of exercise performance in humans is dependent on muscle temperature. Mechanisms underlying the temperature-dependent effect on recovery were studied in intact single mouse muscle fibres where we found that recovery of submaximal force and restoration of fatigue resistance was worsened by cooling (16-26°C) and improved by heating (36°C). Read More

Physiol Behav 2017 Dec 20;182:27-33. Epub 2017 Sep 20.

Department of Clinical Neuroscience, Division for Psychology, Karolinska Institutet, Nobels väg 9, 171 65 Solna, Stockholm, Sweden; Stress Research Institute, Stockholm University, Frescati Hagväg 16A, Stockholm 106 91, Sweden.

Yawning has been proposed to serve both physiological and social functions, the latter likely to have developed later in its evolution. A central hypothesis is that yawning cools the brain but whether yawning is a thermoregulatory mechanism that is activated during hyperthermia (i.e. Read More

J Biomed Mater Res B Appl Biomater 2018 Jul 15;106(5):1827-1841. Epub 2017 Sep 15.

College of Biology, Hunan University, Changsha, Hunan, 410082, China.

Magnetic hyperthermia has been rapidly developed as a potential cancer treatment in recent years. Artificially induced hyperthermia close to a tumor can raise the temperature to 45°C causing tumor cell death. Herein, we introduce a novel method for rapid preparation of anti-cancer magnetocaloric PCL/Fe O mats capable of high-performance hyperthermia using E-jet 3D printing technology. Read More

Mil Med 2017 09;182(9):e1951-e1957

Exercise Science Research Center, University of Arkansas, Department of Health, Human Performance and Recreation, HPER 321, 155 Stadium Drive, Fayetteville, AR 72701.

Background: The procedure of wrapping a heat casualty in ice-water soaked bed sheets to reduce core temperature has received little investigation, despite the practice and recommendation for its use in some military settings. Thus, the purpose of this study was to investigate the cooling efficacy of ice-sheet cooling (ISC) following exertional hyperthermia.

Methods: 13 (11 males, 2 females) participants (age = 23 ± 3 years, height = 176. Read More

J Med Case Rep 2017 Aug 25;11(1):247. Epub 2017 Aug 25.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie-Fang Road, Wuhan, 430030, China.

Background: Congenital insensitivity to pain with anhidrosis is a rare autosomal recessive disorder characterized by hyperpyrexia, anhidrosis, pain insensitivity, self-inflicted injuries, and intellectual disability. The anesthetic management of these patients is challenging owing to the high risk of perioperative complications resulting from their autonomic dysfunction, such as hyperthermia, hypotension, and bradycardia, which result from autonomic nervous system dysfunction.

Case Presentation: Two 3-year-old Han Chinese identical male twins (weighing 13. Read More

Theranostics 2017 7;7(10):2718-2731. Epub 2017 Jul 7.

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada.

The future of nanomedicines in oncology requires leveraging more than just the passive drug accumulation in tumors through the enhanced permeability and retention effect. Promising results combining mild hyperthermia (HT) with lyso-thermosensitive liposomal doxorubicin (LTSL-DOX) has led to improved drug delivery and potent antitumor effects in pre-clinical studies. The ultimate patient benefit from these treatments can only be realized when robust methods of HT can be achieved clinically. Read More

Ther Hypothermia Temp Manag 2017 Sep 16;7(3):118-121. Epub 2017 Aug 16.

4 Penrith Hospital , Cumbria Partnership NHS Foundation Trust, Cumbria, United Kingdom .

Ugeskr Laeger 2017 Jul;179(30)

Hyperthermia is an uncontrolled elevation of body temperature exceeding the body's ability to dissipate heat. Hyperthermia can result in dangerously high core temperatures and can rapidly become fatal. Common causes include heat stroke, malignant hyperthermia, serotonin syndrome, neuroleptic syndrome, a few endocrine emergencies as well as numerous intoxications. Read More

Biopreserv Biobank 2017 Oct 7;15(5):404-409. Epub 2017 Aug 7.

1 Department of Mechanical Engineering, University of Washington , Seattle, Washington.

In the rewarming process during cryopreservation, preventing ice recrystallization and thermal stress is important, especially for large tissues and organs. Uniform and rapid heating is essential in ameliorating the problem and maintaining the viability of cryopreserved biological samples. Currently, the most promising method is heating by application of electromagnetic (EM) waves, the effectiveness of which is dependent on the dielectric properties (DP) of the cryopreserved materials. Read More