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Sci Rep 2022 Jun 3;12(1):9271. Epub 2022 Jun 3.

Department of Physics, K. N. Toosi University of Technology, Shariati, Tehran, 15875-4416, Iran.

This paper studies the effectiveness of the integration of microwave field irradiation and laser emission in liver cancer therapy with the aid of gold nanorods, in order to find out the influences of these combinational methods in tumor necrosis. Hepatocellular carcinoma is a kind of liver cancer that usually has a complicated structure, including both of superficial and deep sections. In current research, in deep regions of cancerous tissue, microwave antenna is utilized and in superficial regions, laser beams are irradiated. Read More

Mil Med 2022 Mar 16. Epub 2022 Mar 16.

Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA.

Introduction: Exertional heat illnesses remain a major threat to military service members in the United States and around the world. Exertional heat stroke (EHS) is the most severe heat illness, characterized by core hyperthermia and central nervous system dysfunction. Per current Army regulations, iced-sheet cooling (ISC) is the recommended immediate treatment for heat casualties in the field, but concerns have been raised regarding the efficacy of this approach. Read More

Appl Ergon 2022 Jul 26;102:103700. Epub 2022 Feb 26.

Institute of Training Medicine and Training Physiology, TGTF, Royal Netherlands Army, the Netherlands. Electronic address:

Purpose: Three feasible cooling methods for treatment of hyperthermic individuals in the military, that differed considerably in water volume needed (none to ~80 L), were evaluated.

Methods: Ten male soldiers were cooled following exercise-induced hyperthermia (rectal temperature (T) ∼39.5 °C) using ventilation by fanning (1. Read More

J Lasers Med Sci 2021 3;12:e55. Epub 2021 Oct 3.

R & D Center, Wontech Co., Ltd., Daejeon 34028, Korea.

Obesity is a global problem because it causes various complications. Methods for reducing fat for healthy life are being studied. In this study, we developed a minimally invasive and non-invasive lipolysis laser system for effective fat reduction. Read More

Anaesthesist 2022 02 20;71(2):85-93. Epub 2022 Jan 20.

Klinik und Poliklinik für Anästhesiologie, Zentrum für Anästhesiologie und Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

The current guidelines of the European Resuscitation Council recommend targeted temperature management to improve functional neurological outcome in comatose survivors after cardiac arrest. With the pathophysiological background of hypothermia-induced neuroprotection for prevention of hypoxic-ischemic encephalopathy, targeted temperature management is a key measure and represents a central aspect in postresuscitation care.In the 2021 guidelines the application of targeted temperature management in postresuscitation care has been recommended for all rhythms and irrespective of the location of cardiac arrest. Read More

Adv Mater 2022 Jan 16;34(4):e2106773. Epub 2021 Dec 16.

Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, P. R. China.

Photothermal therapy (PTT) has emerged as a distinct therapeutic modality owing to its noninvasiveness and spatiotemporal selectivity. However, heat-shock proteins (HSPs) endow tumor cells with resistance to heat-induced apoptosis, severely lowering the therapeutic efficacy of PTT. Here, a high-performance pyroelectric nanocatalyst, Bi S I nanorods (NRs), with prominent pyroelectric conversion and photothermal conversion performance for augmented pyrocatalytic tumor nanotherapy, is developed. Read More

Physiology (Bethesda) 2022 03 11;37(2):69-87. Epub 2021 Oct 11.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.

Hypothermia is defined as a core body temperature of <35°C, and as body temperature is reduced the impact on physiological processes can be beneficial or detrimental. The beneficial effect of hypothermia enables circulation of cooled experimental animals to be interrupted for 1-2 h without creating harmful effects, while tolerance of circulation arrest in normothermia is between 4 and 5 min. This striking difference has attracted so many investigators, experimental as well as clinical, to this field, and this discovery was fundamental for introducing therapeutic hypothermia in modern clinical medicine in the 1950s. Read More

Crit Care Nurse 2021 Oct;41(5):41-50

Maureen McCarthy-Kowols is a former nursing professional development practitioner/clinical educator, Ann & Robert H. Lurie Children's Hospital of Chicago.

Background: In patients with acute neurological injury, abrupt temperature change exacerbates increased intracranial pressures and negatively affects perfusion pressure and cerebral blood flow. Critical care nurses must provide coordinated and effective interventions to maintain normothermia without precipitating shivering immediately after acute neurological injury in pediatric patients.

Objective: To improve hyperthermia management in a 40-bed pediatric intensive care unit, an interdisciplinary pediatric critical care team developed, implemented, and evaluated a targeted temperature management protocol. Read More

J Biomed Phys Eng 2021 Aug 1;11(4):435-446. Epub 2021 Aug 1.

MD, ENT and Head & Neck Research Center and Department, Hazrat Rasoul Hospital, the Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.

Background: Selective targeting of malignant cells is the ultimate goal of anticancer studies around the world. There are some modalities for cancer therapy devastating tumor size and growth rate, meanwhile attacking normal cells. Utilizing appropriate ligands, like folate, allow the delivery of therapeutic molecules to cancer cells selectively. Read More

AORN J 2021 08;114(2):183-191

Using antiseptic solutions in surgical wound irrigation Key words: antiseptic solution, povidone-iodine, wound irrigation, toxicity. Use of powered air-purifying respirators in the OR Key words: respiratory protection, powered air-purifying respirator (PAPR), surgical N95 respirator, unfiltered exhaled air, sterile field contamination. Surgical wound classification of cesarean delivery procedures Key words: surgical wound classification, cesarean delivery, devitalized or infected tissue, contamination. Read More

Crit Care 2021 06 8;25(1):198. Epub 2021 Jun 8.

Department of Medicine Center for Resuscitation Science, Karolinska Institute, Solna, Sweden.

Background: Randomized trials have shown that trans-nasal evaporative cooling initiated during CPR (i.e. intra-arrest) effectively lower core body temperature in out-of-hospital cardiac arrest patients. Read More

J Sci Med Sport 2021 Aug 24;24(8):800-805. Epub 2021 Apr 24.

Department of Life Sciences, University of Roehampton, United Kingdom. Electronic address:

Objectives: To investigate the effects of pre- and per-cooling interventions on subsequent 15-min time-trial (TT) cycling performance in the heat.

Design: Randomized cross-over design.

Methods: Nine male athletes completed four experimental trials in the heat (40 °C, 50% rh): no-cooling (CON); warm-up per-cooling (PER: neck-cooling collar applied during the preload); pre-cooling (PRE: 30 min of cold water (22 °C) immersion [CWI]); and pre- and per-cooling combined (PRE + PER). Read More

Int J Hyperthermia 2021 ;38(1):679-690

Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.

Purpose: Magnetic resonance guided focused ultrasound (MRgFUS) treatment of tumors uses inter-sonication delays to allow heat to dissipate from the skin and other near-field tissues. Despite inter-sonication delays, treatment of tumors close to the skin risks skin burns. This work has designed and evaluated an open-source, conformable, skin-cooling system for body MRgFUS treatments to reduce skin burns and enable ablation closer to the skin. Read More

Front Physiol 2021 1;12:636997. Epub 2021 Apr 1.

Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgium.

In individuals with a spinal cord injury thermoregulatory mechanisms are fully or partially interrupted. This could lead to exercise-induced hyperthermia in temperate conditions which can be even more distinct in hot conditions. Hyperthermia has been suggested to impair physiological mechanisms in athletes, which could negatively influence physical performance and subjective well-being or cause mild to severe health issues. Read More

Physiol Rev 2021 10 8;101(4):1873-1979. Epub 2021 Apr 8.

Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

A rise in body core temperature and loss of body water via sweating are natural consequences of prolonged exercise in the heat. This review provides a comprehensive and integrative overview of how the human body responds to exercise under heat stress and the countermeasures that can be adopted to enhance aerobic performance under such environmental conditions. The fundamental concepts and physiological processes associated with thermoregulation and fluid balance are initially described, followed by a summary of methods to determine thermal strain and hydration status. Read More

J Sports Sci Med 2021 03 1;20(1):26-34. Epub 2021 Mar 1.

Exercise Biological Center, China Institute of Sport Science, Beijing, China.

We investigated whether single or combined methods of pre-cooling could affect high-intensity exercise performance in a hot environment. Seven male athletes were subjected to four experimental conditions for 30 min in a randomised order. The four experimental conditions were: 1) wearing a vest cooled to a temperature of 4 ℃ (Vest), 2) consuming a beverage cooled to a temperature of 4 ℃ (Beverage), 3) simultaneous usage of vest and consumption of beverage (Mix), and 4) the control trial without pre-cooling (CON). Read More

BMC Surg 2021 Mar 5;21(1):112. Epub 2021 Mar 5.

Department of Pediatric Surgery, West China Hospital of Sichuan University, #37 Guo-Xue-Xiang, 610041, Chengdu, China.

Background: Neuroblastoma is the most common malignant extracranial solid tumor in pediatrics patients. Intraoperative hyperthermia is extremely rare in patients with neuroblastoma and can cause a series of complications. Here, we represent a case of neuroblastoma accompanied by hyperthermia during anesthesia, and propose a rational explanation and management options. Read More

Acute Med Surg 2021 Jan-Dec;8(1):e635. Epub 2021 Feb 19.

Department of Emergency Medicine Teikyo University Tokyo Japan.

Background: Heat stroke treatment focuses on rapid cooling because symptom severity correlates with the duration of hyperthermia (i.e., time during which the core body temperature is sustained above the critical threshold). Read More

Cancers (Basel) 2021 Feb 26;13(5). Epub 2021 Feb 26.

Department of Radiology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

The purpose of this study was to evaluate the effectiveness of the clinical setting for deep regional hyperthermia of an 8 MHz radiofrequency (RF) capacitively coupled device in the pelvis by using numerical simulations of the electromagnetic field. A three-dimensional patient model of cervical cancer of the uterus in an obese patient was reconstructed with computed tomography data. The specific absorption rate (SAR) and temperature distributions among the various heating settings were evaluated using numerical simulations. Read More

Perfusion 2022 04 26;37(3):221-228. Epub 2021 Feb 26.

Perfusion Department, Cardiothoracic Theatre, Cardiac Renal Centre, Cork University Hospital, Wilton, Cork, Ireland.

Temperature management is an essential element of cardiopulmonary bypass (CPB), as indicated in the Guide to Good Practice in Clinical Perfusion, 'The safe conduct of CPB requires the clinical perfusionist to measure and control. . . Read More

J Athl Train 2021 Feb 4. Epub 2021 Feb 4.

Hydration, Environment, and Thermal Stress Lab, Department of Kinesiology, University of North Carolina at Greensboro.

Context: Cold-water immersion (CWI) may not be feasible in some remote settings, prompting the identification of alternative cooling methods as adjunct treatment modalities for exertional heat stroke (EHS).

Objective: To determine the differences in cooling capacities between CWI and the inspiration of cooled air.

Design: Randomized controlled clinical trial. Read More

MedEdPORTAL 2021 01 29;17:11092. Epub 2021 Jan 29.

Director of Cook County Simulation Center, Department of Emergency Medicine, Cook County Health; Co-Executive Director, Rush Center for Clinical Skills and Simulation.

Introduction: MDMA (3,4-methylenedioxymethamphetamine) is a popular drug of abuse associated with a variety of clinical manifestations. There are a number of life-threatening sequelae, including, but not limited to, agitated delirium, cardiac dysrhythmias, and hyperthermia. Similar to other substances that cause sympathomimetic toxidromes, MDMA also induces a syndrome of inappropriate antidiuretic hormone secretion-like state resulting in hyponatremia. Read More

Int J Hyperthermia 2021 ;38(1):95-104

Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands.

Purpose: Computer simulations of hepatic radio-frequency ablation (RFA) were performed to: () determine the dependence of the vessel wall heat transfer coefficient on geometrical parameters; () study the conditions required for the occurrence of the directional effect of blood; and () classify blood vessels according to their effect on the thermal lesion while considering blood coagulation. The information thus obtained supports the development of a multi-scale bio-heat model tailored for more accurate prediction of hepatic RFA outcomes in the vicinity of blood vessels.

Materials And Methods: The simulation geometry consisted of healthy tissue, tumor tissue, a mono-polar RF-needle, and a single cylindrical blood vessel. Read More

Int J Hyperthermia 2021 ;38(1):13-21

State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, China.

Magnetic hydrogels (MHGs) have been proposed to avoid the redistribution and loss of magnetic nanoparticles (MNPs) when administrated by intratumoral injection. However, the requirement of complex cooling systems and temperature monitoring systems still hinder the clinical application of MHGs. This study investigates the feasibility of developing an MHG to realize the self-regulation of hyperthermia temperature. Read More

Eur J Appl Physiol 2021 Apr 11;121(4):1061-1071. Epub 2021 Jan 11.

Sports Performance Research Institute New Zealand (SPRINZ), Auckland University of Technology, 17 Antares Place, Rosedale, Auckland, 0632, New Zealand.

Purpose: Cognition can be impaired during exercise in the heat, potentially contributing to military casualties. To our knowledge, the independent role of elevated core temperature during exercise has not been determined. The aim of the current study was to evaluate effects of elevated core temperature on cognition during physically encumbering, heated exercise, and to determine whether the perceptual cooling effects of menthol preserves cognition. Read More

Medicina (Kaunas) 2020 Nov 5;56(11). Epub 2020 Nov 5.

Korey Stringer Institute, University of Connecticut, Storrs, CT 06269-1110, USA.

The purpose of this systematic review is to synthesize the influence cooling modality has on survival with and without medical complications from exertional heat stroke (EHS) in sport and military populations. All peer-reviewed case reports or series involving EHS patients were searched in the following online databases: PubMed, Scopus, SPORTDiscus, Medline, CINAHL, Academic Search Premier, and the Cochrane Library: Central Registry of Clinical Trials. Cooling methods were subdivided into "adequate" (>0. Read More

Sensors (Basel) 2020 Oct 31;20(21). Epub 2020 Oct 31.

Department of Radiation Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Electric permeabilization of cell membranes is the main mechanism of irreversible electroporation (IRE), an ablation technique for treatment of unresectable cancers, but the pulses also induce a significant temperature increase in the treated volume. To investigate the therapeutically thermal contribution, a preclinical setup is required to apply IRE at desired temperatures while maintaining stable temperatures. This study's aim was to develop and test an electroporation device capable of maintaining a pre-specified stable and spatially homogeneous temperatures and electric field in a tumor cell suspension for several clinical-IRE-settings. Read More

Resuscitation 2020 Nov 21;156:A240-A282. Epub 2020 Oct 21.

This is the summary publication of the International Liaison Committee on Resuscitation's 2020 International Consensus on First Aid Science With Treatment Recommendations. It addresses the most recent published evidence reviewed by the First Aid Task Force science experts. This summary addresses the topics of first aid methods of glucose administration for hypoglycemia; techniques for cooling of exertional hyperthermia and heatstroke; recognition of acute stroke; the use of supplementary oxygen in acute stroke; early or first aid use of aspirin for chest pain; control of life- threatening bleeding through the use of tourniquets, haemostatic dressings, direct pressure, or pressure devices; the use of a compression wrap for closed extremity joint injuries; and temporary storage of an avulsed tooth. Read More

Circulation 2020 10 21;142(16_suppl_1):S284-S334. Epub 2020 Oct 21.

This is the summary publication of the International Liaison Committee on Resuscitation's . It addresses the most recent published evidence reviewed by the First Aid Task Force science experts. This summary addresses the topics of first aid methods of glucose administration for hypoglycemia; techniques for cooling of exertional hyperthermia and heatstroke; recognition of acute stroke; the use of supplementary oxygen in acute stroke; early or first aid use of aspirin for chest pain; control of life-threatening bleeding through the use of tourniquets, hemostatic dressings, direct pressure, or pressure devices; the use of a compression wrap for closed extremity joint injuries; and temporary storage of an avulsed tooth. Read More

Medicina (Kaunas) 2020 Oct 14;56(10). Epub 2020 Oct 14.

Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.

Exertional heat stroke (EHS) is a potentially lethal, hyperthermic condition that warrants immediate cooling to optimize the patient outcome. The study aimed to examine if a portable cooling vest meets the established cooling criteria (0.15 °C·min or greater) for EHS treatment. Read More