Search Our Scientific Publications & Authors

J Dairy Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Animal Sciences, University of Florida, Gainesville 32611. Electronic address:

Although dairy calves are more thermotolerant relative to mature cows, they are still susceptible to heat stress, as demonstrated by elevated physiological responses and reduced feed intake under high ambient temperature and relative humidity. However, indicators of heat stress have not been well-characterized in calves. Herein, we evaluated associations between environmental and thermoregulatory and productive animal-based indicators of heat stress in dairy calves exposed to chronic heat stress or continuous cooling in a subtropical climate. Read More

Int J Hyperthermia 2020 ;37(1):668-676

Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore, Singapore.

To explore various microwave (MW) time/power combinations to achieve maximum single-probe system performance in a live pig liver model. Fifty-one microwave ablations performed in 12 female pigs using the following time/power combinations: 65 W for 10 min (65W 10MIN), ramped from 20 to 65 W (RAMPED), 95 W pulses with cooling periods (95W PULSED), 40 W for 16 min 15 s (LOW POWER), 1 min 95 W pulse then 8 min 65 W then a second 1 min 95 W pulse (BOOKEND 95W) and 65 W for 15 min (65W 15MIN). Temperatures 1. Read More

SAGE Open Med 2020 3;8:2050312120928732. Epub 2020 Jun 3.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Objectives: Fever control has been shown to reduce short-term mortality in patients with septic shock. This study aimed to explore the feasibility of early intensive fever control in patients with septic shock and to assess the immunomodulatory effects of this intervention.

Methods: In this single-center, randomized, open-label trial, febrile patients with septic shock presenting to the emergency department were assigned to either a standard fever control or therapeutic normothermia group. Read More

Int J Hyperthermia 2020 ;37(1):634-650

Ascend Technologies Ltd., Southampton, UK.

The thermally-induced urine flow can generate cooling that may alter the treatment outcome during hyperthermic treatments of bladder cancer. This paper investigates the effects of natural convection inside the bladder and at skin surface during gold nanorods (GNR) - assisted photothermal therapy (PTT) of bladder cancer in mice. 3D models of mouse bladder at orientations corresponding to the mouse positioned on its back, its side and its abdomen were examined. Read More

Minerva Anestesiol 2020 May 28. Epub 2020 May 28.

Department of Intensive Care, Erasme University Hospital Université Libre de Bruxelles, Brussels, Belgium -

Among comatose survivors after cardiac arrest, target temperature management (TTM) is considered the most effective treatment to reduce the consequences of post-anoxic brain injury. Several international guidelines have thus incorporated TTM in the management of the post- resuscitation phase. However, despite extremely promising results in animal models and in randomized trials including selected patient cohorts, TTM benefits on neurological outcome have been questioned. Read More

Spinal Cord Ser Cases 2019 05 28;5(1):51. Epub 2019 May 28.

School of Health Professions, Physical Therapy Department, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Study Design: Interventional crossover study.

Objective: Spinal cord injury (SCI) disrupts afferent input to the hypothalamus and impairs efferent vaso- and sudomotor output, especially in lesions above the sympathetic chain (T1-L2). In consequence, persons with SCI under heat stress experience impairment in the ability to dissipate heat proportional to the lesion level. Read More

Int J Environ Res Public Health 2020 04 24;17(8). Epub 2020 Apr 24.

Department of Functional Biology, Universidad de Oviedo, 33006 Oviedo, Spain.

The current systematic review evaluated the effects of different pre-cooling techniques on sports performance in highly-trained athletes under high temperature conditions. PubMed/MEDLINE, EMBASE, Web of Science, CENTRAL, Scopus, and SPORTDiscus databases were searched from inception to December 2019. Studies performing pre-cooling interventions in non-acclimatized highly-trained athletes (>55 mL/kg/min of maximal oxygen consumption) under heat conditions (≥30 °C) were included. Read More

Br J Sports Med 2020 Jan 28. Epub 2020 Jan 28.

Aspetar Orthopaedic and Sports Medicine Hospital, Doha, Qatar.

Purpose: Assess the health status and heat preparation strategies of athletes competing in a World Cycling Championships held in hot ambient conditions (37°C, 25% relative humidity, wet-bulb-globe-temperature 27°C) and monitor the medical events arising during competition.

Methods: 69 cyclists (~9% of the world championships participants) completed a pre-competition questionnaire. Illnesses and injuries encountered by the Athlete Medical Centre (AMC) were extracted from the race reports. Read More

Resuscitation 2020 Mar 22;148:173-190. Epub 2020 Jan 22.

St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address:

Background: Heat stroke is an emergent condition characterized by hyperthermia (>40 °C/>104 °F) and nervous system dysregulation. There are two primary etiologies: exertional which occurs during physical activity and non-exertional which occurs during extreme heat events without physical exertion. Left untreated, both may lead to significant morbidity, are considered a special circumstance for cardiac arrest, and cause of mortality. Read More

Mediators Inflamm 2019 21;2019:6431957. Epub 2019 Nov 21.

Department of Congenital Heart Disease/Pediatric Cardiology, Universitäres Herzzentrum Berlin-Medical Heart Center of Charité and German Heart Institute Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

Introduction: Fever is frequently observed after acute ischemic events and is associated with poor outcome and higher mortality. Targeted temperature management (TTM) is recommended for neuroprotection in comatose cardiac arrest survivors, but pyrexia after rewarming is proven to be detrimental in clinical trials. However, the cellular mechanisms and kinetics of post-TTM rebound pyrexia remain to be elucidated. Read More

Burns 2020 02 16;46(1):104-109. Epub 2019 Dec 16.

Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tuebingen, Germany.

Introduction: Knowledge of thermally induced skin injury has increased, but its pathophysiology remains unclear. Although it is assumed that local cooling may protect tissue, little is known about the impact of local heating on human skin. This study aimed to evaluate acute skin perfusion dynamics following thermal stimuli in healthy human volunteers. Read More

Prehosp Disaster Med 2020 Feb 6;35(1):41-45. Epub 2019 Dec 6.

Edith Cowan University, School of Medical and Health Sciences, Joondalup, Western Australia, Australia.

Introduction: Serotonin and sympathomimetic toxicity (SST) after ingestion of amphetamine-based drugs can lead to severe morbidity and death. There have been evaluations of the safety and efficacy of on-site treatment protocols for SST at music festivals.

Problem: The study aimed to examine the safety and efficacy of treating patients with SST on-site at a music festival using a protocol adapted from hospital-based treatment of SST. Read More

BMC Med Inform Decis Mak 2019 10 28;19(1):201. Epub 2019 Oct 28.

Institute of Forensic Medicine, University of Zürich, Campus Irchel, Zürich, 8057, Switzerland.

Background: Time of death estimation in humans for the benefit of forensic medicine has been successfully approached by Henssge, who modelled body cooling based on measurements of Marshall and Hoare. Thereby, body and ambient temperatures are measured at the death scene to estimate a time of death based on a number of assumptions, such as initial body temperature and stable ambient temperature. While so far, practical use of the method resorted to paper print outs or copies of a nomogram using a ruler, increasingly, users are interested in computer or mobile device applications. Read More

Spinal Cord Ser Cases 2019 28;5:51. Epub 2019 May 28.

3School of Health Professions, Physical Therapy Department, University of Texas Health Science Center at San Antonio, San Antonio, TX USA.

Study Design: Interventional crossover study.

Objective: Spinal cord injury (SCI) disrupts afferent input to the hypothalamus and impairs efferent vaso- and sudomotor output, especially in lesions above the sympathetic chain (T1-L2). In consequence, persons with SCI under heat stress experience impairment in the ability to dissipate heat proportional to the lesion level. Read More

J Emerg Med 2019 Nov 16;57(5):713-715. Epub 2019 Oct 16.

Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

Background: Methamphetamine can cause life-threatening hyperthermia and treatment must be aggressive and rapid. There are multiple methods of cooling, with cold-water immersion being one of the most effective treatment options. However, this method is technically difficult to institute in the emergency department setting. Read More

J Sport Rehabil 2019 Oct 18:1-6. Epub 2019 Oct 18.

Clinical Scenario: In the last few years, there have been several studies examining alternative cooling strategies in the treatment of exertional heat stroke (EHS). Morbidity and mortality with EHS are associated with how long the patient's core body temperature remains above the critical threshold of 40.5°C. Read More

East Mediterr Health J 2019 Oct 4;25(7):457-464. Epub 2019 Oct 4.

Department of Hematology, Liaquat National Hospital, Karachi, Pakistan.

Background: Climate change has heightened the threat of heat stroke in previously temperate zones.

Aims: This study aimed to assess the outcome of patients in relation to mortality and the role of effect modifiers among heatstroke patients presenting to a tertiary care hospital in Karachi during June 2015.

Methods: A retrospective observational study was conducted on heatstroke patients 20-27 June 2015 at the Emergency Room(ER) of a private hospital in Karachi, Pakistan. Read More

Intensive Care Med 2019 10 1;45(10):1382-1391. Epub 2019 Oct 1.

Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Purpose: It is unknown whether protocols targeting systematic prevention and treatment of fever achieve lower mean body temperature than usual care in intensive care unit (ICU) patients. The objective of the Randomised Evaluation of Active Control of temperature vs. ORdinary temperature management trial was to confirm the feasibility of such a protocol with a view to conducting a larger trial. Read More

Int J Hyperthermia 2019 ;36(1):980-985

Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou , PR China.

This study aimed to evaluate the risk factors of biloma formation and secondary infection after thermal ablation for malignant hepatic tumors. A total of 58 patients with 68 bilomas after thermal ablation were recruited as the complication group, and 61 patients with 72 lesions without major complications were selected randomly as the control group. The potential risk factors for biloma formation were analyzed with the chi-square test and multivariate logistic regression analysis. Read More

Environ Res Lett 2019 Aug 26;14(8). Epub 2019 Jul 26.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States.

Background: With climate change, adverse human health effects caused by heat exposure are of increasing public health concern. Forests provide beneficial ecosystem services for human health, including local cooling. Few studies have assessed the relationship between deforestation and heat-related health effects in tropical, rural populations. Read More

Int J Hyperthermia 2019 ;36(1):801-811

Department of Radiation Oncology, University Medical Center Rotterdam, Erasmus MC - Cancer Institute , Rotterdam , The Netherlands.

To investigate the effect of patient specific vessel cooling on head and neck hyperthermia treatment planning (HTP). Twelve patients undergoing radiotherapy were scanned using computed tomography (CT), magnetic resonance imaging (MRI) and contrast enhanced MR angiography (CEMRA). 3D patient models were constructed using the CT and MRI data. Read More

Rev Bras Enferm 2019 Aug 19;72(4):1114-1118. Epub 2019 Aug 19.

Universidade Federal de São Paulo, Escola Paulista de Enfermagem. São Paulo, São Paulo, Brazil.

Objective: to report the experience of conducting directed temperature control of a post-cardiopulmonary resuscitation patient, with reduced and basic inputs available at the institution.

Method: an experience report of directed temperature control in patient (age 15 years), after four hours of cardiopulmonary resuscitation in an Intensive Care Unit of a hospital in São Paulo State countryside in 2016, according to the protocol suggested by the American Heart Association, in 2015. There were applications of cold compresses, plastic bags with crushed ice and rectal temperature control. Read More

Int J Hyperthermia 2019 ;36(1):739-743

b Department of Gynecology, Iseikai Hospital , Osaka , Japan.

Vascular-rich myomas are resistant to treatment involving transcervical microwave myolysis. To overcome cooling by blood perfusion, we injected dilute vasopressin solution into the space between the myometrium and the surface of the vascular-rich myomas. Seven outpatients [age (mean ± SD age), 44. Read More

Am J Health Syst Pharm 2019 Jul;76(14):1029-1032

Division of Pulmonary, Critical Care, and Sleep Medicine, Palmetto Health USC Medical Group, Columbia, SC.

Purpose: A case report involving varying cisatracurium dosing requirements in a hyperthermic patient undergoing prone ventilation who subsequently received active cooling as part of targeted temperature management is presented.

Summary: Cisatracurium is known to be primarily metabolized via pH- and temperature-dependent Hofmann elimination. Previous reports in the literature described cases of decreased dosing requirements for both cisatracurium and its parent compound, atracurium, for patients in hypothermic states. Read More

Scand J Med Sci Sports 2019 Nov 14;29(11):1660-1676. Epub 2019 Aug 14.

Laboratoire Mobilité Vieillissement Exercice (MOVE)-EA6314, Faculty of Sport Sciences, University of Poitiers, Poitiers, France.

Introduction: Hyperthermia during exercise induces central and peripheral fatigue and impairs physical performance. To facilitate heat loss and optimize performance, athletes can hasten body cooling prior (pre-cooling) or during (per-cooling) exercise. However, it is unclear whether per-cooling effect is the same on 'aerobic' and 'anaerobic' types of exercise (duration <75 and >76 seconds, respectively, according to Gastin [Sports Med 2001;31:725-741]) and whether the body area that is cooled makes a difference. Read More

J Therm Biol 2019 Jul 3;83:37-46. Epub 2019 May 3.

Centre for Human and Applied Physiology, School of Medicine, University of Wollongong, Wollongong, NSW, 2522, Australia.

To better understand the relationships between changes in body temperature and displacements of the thermoeffector thresholds (critical temperatures), the passive cooling (and heating) of pre-heated (and pre-cooled) individuals was investigated. Such experiments are necessary to understand the inter-dependence of those thresholds, and may possibly yield human evidence for the existence of separate central controllers. Eight males participated in four trials; two when normothermic, one following pre-experimental heating and the fourth following pre-cooling. Read More

Clin Neurol Neurosurg 2019 Sep 2;184:105412. Epub 2019 Jul 2.

Department of Neurology, Henry Ford Health System, Wayne State School of Medicine, Detroit, MI, United States. Electronic address:

Objectives: Fever occurs in up to 50% of critically-ill patients with acute neurological injury. Small temperature elevations have been correlated with increased morbidity and mortality in this patient population. We sought to evaluate a novel single-use surface cooling system for the treatment of fever in patients with acute brain injury. Read More

Eur J Appl Physiol 2019 Aug 20;119(8):1885-1899. Epub 2019 Jun 20.

Athlete Health and Performance Research Centre, Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar.

Purpose: This study examined the effects of combined cooling and lower body heat maintenance during half-time on second-half intermittent sprint performances.

Methods: In a repeated measures design, nine males completed four intermittent cycling trials (32.1 ± 0. Read More

Int J Mol Sci 2019 Jun 12;20(12). Epub 2019 Jun 12.

Gwangju Institute of Science and Technology, School of Integrated Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju 61005, Korea.

A wireless magnetothermal stimulation (WMS) is suggested as a fast, tetherless, and implanted device-free stimulation method using low-radio frequency (100 kHz to 1 MHz) alternating magnetic fields (AMF). As magnetic nanoparticles (MNPs) can transduce alternating magnetic fields into heat, they are targeted to a region of the brain expressing the temperature-sensitive ion channel (TRPV1). The local temperature of the targeted area is increased up to 44 °C to open the TRPV1 channels and cause an influx of Ca sensitive promoter, which can activate individual neurons inside the brain. Read More

Diagn Interv Radiol 2019 Jul;25(4):291-297

Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Purpose: We aimed to investigate the exact role of residual thermal energy following microwave ablation (MWA) and radiofrequency ablation (RFA) at the final ablation and transition zones and determine whether residual thermal energy could be dissipated by subsequent cooling-circulation.

Methods: In an ex vivo study, MWA and RFA were performed on fresh porcine liver, and central and border temperatures were compared. In an in vivo study, MWA and RFA were performed to the livers of New Zealand white rabbits. Read More

Med Sci Sports Exerc 2019 10;51(10):2025-2032

Human Performance Laboratory, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX.

It is well known that hyperthermia lowers stroke volume (SV) during moderate-intensity prolonged exercise, yet the underlying mechanism is inconclusive, especially when skin temperature (Tsk) is hot (≥38°C).

Purpose: In the present study, HR was independently lowered by a low dose of β1-blockade (βB) to investigate its effect on SV during exercise when skin is hot. The effect of rapid skin cooling on reversing cardiovascular responses was also examined. Read More

Front Physiol 2019 12;10:424. Epub 2019 Apr 12.

Institute of Health and Biomedical Innovation, School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, QLD, Australia.

Objective: The use of personal cooling systems to mitigate heat strain on first-responders achieves two potential performance benefits relative to the absence of such cooling: (1) the completion of a workload with less effort; and/or (2) the completion of a greater workload for the same effort. Currently, claims made by manufacturers regarding the capability of their products for use in conjunction with chemical/biological protective clothing remain largely unsubstantiated. The purpose of this investigation was to evaluate the means by which heat strain can be alleviated during uncompensable heat stress in chemical/biological clothing, using the ASTM F2300-10 methodology. Read More

Neurocrit Care 2019 10;31(2):280-287

Department of Anesthesiology-Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Fever is an important determinant of prognosis following acute brain injury. Current non-pharmacologic techniques to reduce fever are limited and induce a shivering response. We investigated the safety and efficacy of a novel transnasal unidirectional high flow air device in reducing core body temperature in the neurocritical care unit (NCCU) setting. Read More

J Ethnopharmacol 2019 Jun 22;238:111828. Epub 2019 Mar 22.

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla Univesity, Hat-Yai, Songkhla, 90112, Thailand; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand; Excellent Research Laboratory, Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, 90112, Thailand. Electronic address:

Ethnopharmacological Relevance: Curcuma mangga Valeton & Van Zijp. (Zingiberaceae family) contains curcuminoids and diterpenes which have anti-inflammatory effect. In traditional use, the elixir of this plant has been used to detoxify the poisonous plants, treatment of gastric ulcer, chest pain, fever, skin disease and womb healing. Read More

J Dent Sci 2018 Sep 7;13(3):263-266. Epub 2018 Jun 7.

Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC.

Background/purpose: It was found that body temperature would be gradually increased during pediatric full mouth rehabilitation surgery. Although the etiology is unknown, here, we introduced an effective method to maintain normothermia during this kind of surgery.

Materials And Methods: Following IRB approval, the medical records of pediatric patients who received full mouth rehabilitation surgery from Jan. Read More

Int J Sports Physiol Perform 2019 Jul 30:1212-1218. Epub 2019 Jul 30.

Purpose: To determine how a cooling vest worn during a warm-up could influence selected performance (countermovement jump [CMJ]), physical (global positioning system [GPS] metrics), and psychophysiological (body temperature and perceptual) variables.

Methods: In a randomized, crossover design, 12 elite male World Rugby Sevens Series athletes completed an outdoor (wet bulb globe temperature 23-27°C) match-specific externally valid 30-min warm-up wearing a phase-change cooling vest (VEST) and without (CONTROL), on separate occasions 7 d apart. CMJ was assessed before and after the warm-up, with GPS indices and heart rate monitored during the warm-ups, while core temperature (Tc; ingestible telemetric pill; n = 6) was recorded throughout the experimental period. Read More

Phytomedicine 2020 Aug 31;74:152815. Epub 2018 Dec 31.

Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, China; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. Electronic address:

Background: According to traditional Chinese medicine (TCM) theory, the herbal property is the most important guiding principle of ancient medication in China. The classification of warm- and cold-stimulating TCM is defined mainly based on the effects of herbs in regulating body temperature; however, the underlying mechanism of such distinction has not been fully identified.

Methods: Here, four commonly used spleen-meridian herbs, Ginseng Radix and Astragali Radix as typical warm-stimulating herbs, and Nelumbinis Semen and Coicis Semen as typical cold-stimulating herbs, were selected to test their effects in regulating body temperature, as well as its triggered thermo-regulatory factors and energy related metabolites, in yeast-induced fever rats. Read More

Crit Rev Biomed Eng 2018 ;46(6):495-521

Department of Electrical and Computer Engineering, Kansas State University, Manhattan, Kansas.

Microwave (MW) ablation has emerged as a minimally invasive therapeutic modality and is in clinical use for treatment of unresectable tumors and cardiac arrhythmias, neuromodulation, endometrial ablation, and other applications. Components of image-guided MW ablation systems include high-power MW sources, ablation applicators that deliver power from the generator to the target tissue, cooling systems, energy-delivery control algorithms, and imaging guidance systems tailored to specific clinical indications. The applicator incorporates a MW antenna that radiates MW power into the surrounding tissue. Read More

Top Spinal Cord Inj Rehabil 2019 ;25(1):74-82

Audie L. Murphy VA, San Antonio, Texas.

Decentralization of the sympathetic nervous system in persons with spinal cord injury (SCI) results in impaired vasomotor and sudomotor activity and, subsequently, impaired thermoregulatory capacity during exercise in the heat. Hyperthermia can be life-threatening and, as such, cooling interventions are needed to prevent this sequela. To measure change in core temperature (ΔT) over time during exercise in normothermic and high ambient heat conditions to compare thermoregulatory capacity in persons with varying degrees of intact vasomotor and sudomotor activity and to determine the efficacy of three cooling interventions in mitigating T rise. Read More

Lasers Med Sci 2019 Sep 14;34(7):1421-1431. Epub 2019 Feb 14.

Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991.

To improve methods of laser hyperthermia for the treatment of bulk malignant neoplasms, an urgent task is the development of techniques and devices that automatically control heating at a given tissue depth and ensure its uniformity. The article proposes the concept of a system for performing hyperthermia with real-time spectroscopic temperature control and surface cooling, which allows to record spectra of diffusely scattered radiation and fluorescent signal from various depths of biological tissues by the means of the variation of the angle and distance between the fiber source of laser radiation and the receiving fiber. Theoretical and experimental modeling of the spatial distribution of diffusely scattered radiation and temperature inside the tissue with a fiber optic device providing surface cooling of the irradiated tissue, and recording spectral information from a given depth in real time, is presented. Read More

Intensive Care Med 2019 04 11;45(4):468-476. Epub 2019 Feb 11.

University of Otago, Wellington, New Zealand.

Purpose: One potential way to protect patients from the physiological demands that are a consequence of fever is to aim to prevent fever and to treat it assiduously when it occurs. Our primary hypothesis was that more active fever management would increase survival among patient subgroups with limited physiological reserves such as older patients, patients with higher illness acuity, and those requiring organ support.

Methods: We conducted an individual-level patient data meta-analysis of randomised controlled trials to compare the outcomes of ICU patients who received more active fever management with the outcomes of patients who received less active fever management. Read More

Ther Hypothermia Temp Manag 2019 Dec 18;9(4):238-242. Epub 2019 Jan 18.

Department of Emergency Medicine, Southwestern Medical Centre, The University of Texas, Dallas, Texas.

Traumatic brain injury (TBI) is a leading cause of death in the United States, and represents 2.5 million Emergency Department attendances, admissions into hospital, and deaths. A range of temperature modulating devices have been used to proactively cool TBI patients; however, there are currently no uniform targeted temperature management (TTM) guidelines in this patient population. Read More

Aerosp Med Hum Perform 2019 Jan;90(1):12-17

Precooling (PC) before exercise may help prevent severe hyperthermia and exertional heatstroke (EHS). Before clinicians can advocate PC as an EHS prevention strategy, it must effectively mitigate factors associated with EHS development while not lessening the effectiveness of EHS treatment. Therefore, this study determined if PC affected rectal temperature (T), body heat storage, heart rate (HR), ratings of perceived exertion (RPE), thermal sensation, sweat rate, and postexercise cold-water immersion (CWI) T cooling rates. Read More

Pediatr Crit Care Med 2019 02;20(2):e77-e82

PICU, Hospital General Universitario Gregorio Marañon, Universidad Complutense de Madrid, Maternal and Child Health and Development Network (Red SAMID), Madrid, Spain.

Objectives: It is currently recommended that after return of spontaneous circulation following cardiac arrest, fever should be prevented using TTM through a servo-controlled system. This technology is not yet available in many global settings, where manual physical measures without servo-control is the only option. Our aim was to compare feasibility, safety and quality assurance of servo-controlled system versus no servo-controlled system cooling, TTM protocols for cooling, maintenance and rewarming following return of spontaneous circulation after cardiac arrest in children. Read More

J Therm Biol 2018 Dec 1;78:329-342. Epub 2018 Nov 1.

Department of Mechanical Engineering, NIT Arunachal Pradesh, Yupia 791112, India. Electronic address:

Attaining a precise necrosis of tumor sparing normal tissue during carcinomas thermo-therapy via nominally invasive scheme like irradiation of laser is a recent challenge. In this study, a combined diffusion and convective energy equations were solved using COMSOL Multiphysics to predict the tissue thermal profile during laser assisted thermo-therapy with different tissue vascular networks. A comparative analysis between intratumoral and intravenous loading scheme of silica-gold nanoshells (AuNs) was also performed. Read More

Ann Biomed Eng 2019 Feb 28;47(2):537-548. Epub 2018 Nov 28.

School of Engineering, Discipline of Electrical and Biomedical Engineering, RMIT University, Plenty Road, Bundoora, 3083, Australia.

Thermotherapy is considered to have potential beneficial effects when applied to wounds. Of particular relevance to this research are wounds that have dropped in temperature due to regional anaesthesia. This study is aimed at developing a normothermic system comprising of a heat patch controlled by external hardware. Read More

Int J Hyperthermia 2019 28;36(1):75-86. Epub 2018 Nov 28.

d Department of Information Engineering , University of Florence , Firenze , Italy.

Purpose: Bleeding from parenchyma transection during a robotic hepatic surgery remains the most critical point affecting postoperative recovery and long-term survival. Various robotic devices with different types of energies have been proposed; however, each of these lack in steerability, efficacy, or accuracy. The aim of this work is to evaluate the feasibility and performance of a new steerable microwave resection device intended for minimizing intraoperative blood loss during laparoscopic and robotic liver resections. Read More

Network 2018 8;29(1-4):20-36. Epub 2018 Nov 8.

a Faculty of Electronic Engineering (FEE) , Menoufia University , Menouf , Egypt.

Thermal dose is an important clinical efficacy index for hyperthermia cancer treatment. This paper presents a new direct radial basis function (RBF) neural network controller for high-temperature hyperthermia thermal dose during the therapeutic procedure of cancer tumours by short-time pulses of high-intensity focused ultrasound (HIFU). The developed controller is stabilized and automatically tuned based on Lyapunov functions and ant colony optimization (ACO) algorithm, respectively. Read More

Resuscitation 2019 01 22;134:49-54. Epub 2018 Oct 22.

Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Purpose: Early initiation of hypothermia is recommended in the setting of cardiac arrest. Current hypothermia methods are invasive and expensive and not applicable in ambulatory settings. We investigated the evaporative cooling effect of high flow transnasal dry air on core esophageal temperature in human volunteers. Read More

Eur J Sport Sci 2019 May 10;19(4):432-441. Epub 2018 Oct 10.

f School of Health and Human Sciences , Southern Cross University , Coffs Harbour , Australia.

Purpose: To characterize player core temperature (Tc) across two separate World Rugby Sevens Series (WRSS) tournaments in temperate and warm environments.

Methods: Tc was collected in seventeen playing members of one men's team competing at the Singapore (n = 12) and London (n = 11) WRSS tournaments. Exertional heat illness (EHI) symptoms, cooling strategy use, playing minutes and wet blub globe temperature (WBGT) were also collected. Read More