4,212 results match your criteria Cooley Anemia

Effectiveness of a multidisciplinary rehabilitation program in real-world patients with chronic back pain: A pilot cohort data analysis.

J Back Musculoskelet Rehabil 2021 Jun 16. Epub 2021 Jun 16.

Background: Randomized clinical trials (RCT) suggest a multidisciplinary approach to pain rehabilitation is superior to other active treatments in improving pain intensity, function, disability, and pain interference for patients with chronic pain, with small effect size (ds= 0.20-0.36) but its effectiveness remains unknown in real-world practice. Read More

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Organizational perspectives on outdoor talking therapy: Towards a position of 'environmental safe uncertainty'.

Br J Clin Psychol 2021 Jun 12. Epub 2021 Jun 12.

Department of Neuroscience, Psychology and Behaviour, University of Leicester, UK.

Objectives: There is growing support within the therapy professions for using talking therapy in alternative environments, such as outdoor spaces. The aim of the present study was to further understand how the organizational culture in clinical psychology may prevent or enable practitioners to step outside the conventional indoor consulting room.

Design: Informed grounded theory methodology was used within a pragmatist philosophy. Read More

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Following Transplantation for Acute Myelogenous Leukemia, Donor Better Protects against Relapse than .

J Immunol 2021 Jun 11. Epub 2021 Jun 11.

Department of Structural Biology, Stanford University, Stanford, CA;

In the treatment of acute myelogenous leukemia with allogeneic hematopoietic cell transplantation, we previously demonstrated that there is a greater protection from relapse of leukemia when the hematopoietic cell transplantation donor has either the / genotype or a genotype having two or more gene segments. In those earlier analyses, genotyping could only be assessed at the low resolution of gene presence or absence. To give the analysis greater depth, we developed high-resolution sequence-based typing that defines all the alleles and distinguishes the expressed alleles from those that are not expressed. Read More

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A Patient-Focused Survey to Assess the Effects of the COVID-19 Pandemic and Social Guidelines on People with Muscular Dystrophy.

Muscle Nerve 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas.

Introduction: In this study, we examined the social and health impacts of the coronavirus disease 2019 (COVID-19) pandemic and social guidelines on people with muscular dystrophies.

Methods: A prospective de-identified electronic survey was distributed to adults with self-reported facioscapulohumeral muscular dystrophy (FSHD), myotonic dystrophy (DM), and limb-girdle muscular dystrophy (LGMD) enrolled in national registries or with patient advocacy groups. The COVID-19 Impact Survey was developed by muscular dystrophy experts in association with patient collaborators and advocacy groups. Read More

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Comparison of Dermatologist Ratings on Health Care-Specific and General Consumer Websites.

Cutis 2021 Apr;107(4):182-184

Weill Cornell Medical College, New York, New York. Ms. Cooley is from the Clinical and Translational Science Center. Dr. Lipner is from the Department of Dermatology.

Many patients utilize online physician-rating websites to find new providers, review their experiences, and schedule appointments. However, many physicians express distrust of the reviews on these sites. This study sought to compare the reviews of randomly selected dermatologists on health care-specific sites (eg, Healthgrades, Zocdoc, Vitals, WebMD) vs general consumer sites (eg, Google, Yelp) to determine which type of sites more accurately reflected overall patient sentiment. Read More

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The Americanization of Karen Refugee Youth: Exploring Attitudes Toward and Use of Methamphetamine.

Int J Offender Ther Comp Criminol 2021 Jun 2:306624X211022655. Epub 2021 Jun 2.

University of Nebraska, Omaha, USA.

Drug use among refugee populations is a concerning trend in many urban American cities. For instance, Omaha, Nebraska is home to an estimated 7,000 refugees from Myanmar, with at least 75% of those being Karen refugees. The purpose of this paper is to explore methamphetamine use among Karen adolescents in Omaha and to examine whether Karen youth bring their drug use habits with them from refugee camps or if they learn about drugs from their American peers. Read More

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What does experiential education look like in a global pandemic? Reflecting back and looking forward.

Curr Pharm Teach Learn 2021 07 2;13(7):881-884. Epub 2021 Apr 2.

St. Louis College of Pharmacy, 1 Pharmacy Place, St. Louis, MO 63110, United States. Electronic address:

Purpose: The purpose of this reflection or wisdom of experience article is to describe and reflect on the impacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on experiential education (EE) leadership and teams. Additionally, this reflection will shift the focus from the spring 2020 environment of SARS-CoV-2 to what EE teams and college administration can learn from those experiences. Moving forward, EE teams and administrators can be better equipped to proactively plan for future emergencies. Read More

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Does Parenting Style Affect Adolescent IBD Transition Readiness and Self-Efficacy Scores?

Children (Basel) 2021 May 4;8(5). Epub 2021 May 4.

Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Background: Transition to adult-centered care requires adolescents with inflammatory bowel disease (IBD) to acquire a set of independent self-management skills. Transition success can be affected by maturity, cognitive development, and many other factors. Our hypothesis was that parenting style would be associated with increased self-efficacy and therefore transitions readiness. Read More

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Increased Production of Outer Membrane Vesicles by Salmonella Interferes with Complement-Mediated Innate Immune Attack.

mBio 2021 Jun 1:e0086921. Epub 2021 Jun 1.

Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.

Bacterial outer membrane vesicles (OMVs) enriched with bioactive proteins, toxins, and virulence factors play a critical role in host-pathogen and microbial interactions. The two-component system PhoP-PhoQ (PhoPQ) of Salmonella enterica orchestrates the remodeling of outer membrane lipopolysaccharide (LPS) molecules and concomitantly upregulates OMV production. In this study, we document a novel use of nanoparticle tracking analysis to determine bacterial OMV size and number. Read More

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Three-dimensional adaptive optical nanoscopy for thick specimen imaging at sub-50-nm resolution.

Nat Methods 2021 Jun 31;18(6):688-693. Epub 2021 May 31.

Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.

Understanding cellular organization demands the best possible spatial resolution in all three dimensions. In fluorescence microscopy, this is achieved by 4Pi nanoscopy methods that combine the concepts of using two opposing objectives for optimal diffraction-limited 3D resolution with switching fluorescent molecules between bright and dark states to break the diffraction limit. However, optical aberrations have limited these nanoscopes to thin samples and prevented their application in thick specimens. Read More

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Percutaneous and Open Tracheostomy in Patients With COVID-19: The Weill Cornell Experience in New York City.

Laryngoscope 2021 May 26. Epub 2021 May 26.

Department of Otolaryngology-Head and Neck Surgery, NewYork-Presbyterian Hospital/Weill Cornell Medicine, New York, New York, U.S.A.

Objective: Report long-term tracheostomy outcomes in patients with COVID-19.

Study Design: Review of prospectively collected data.

Methods: Prospectively collected data were extracted for adults with COVID-19 undergoing percutaneous or open tracheostomy between April 4, 2020 and June 2, 2020 at a major medical center in New York City. Read More

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HDAC2 links ubiquitination to tumor suppression in synovial sarcoma.

Mol Cell Oncol 2021 Apr 25;8(3):1914291. Epub 2021 Apr 25.

HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.

The function of histone deacetylase 2 (HDAC2) in transcriptional regulation and its role in oncogenesis have been well established. Here we discuss a transcription-independent HDAC2 pathway controlling cancer-related protein stability via the mouse double minute 2 homolog (MDM2) ubiquitin ligase. In synovial sarcoma, HDAC2 inactivation demonstrates significant therapeutic effect by degradation of the SS18-SSX driver oncoprotein. Read More

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Combining Stereotactic Body Radiotherapy and Microwave Ablation Appears Safe and Feasible for Renal Cell Carcinoma in an Early Series.

Clin Genitourin Cancer 2021 Apr 20. Epub 2021 Apr 20.

Department of Human Oncology, University of Wisconsin Hospitals & Clinics, Madison, WI.

Microwave (MW) ablation and stereotactic body radiation therapy (SBRT) are both used in treating inoperable renal cell carcinoma (RCC). MW ablation and SBRT have potentially complementary advantages and limitations. Combining SBRT and MW ablation may optimize tumor control and toxicity for patients with larger (> 5 cm) RCCs or those with vascular involvement. Read More

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Carios kelleyi (Acari: Ixodida: Argasidae) Infected With Rickettsial Agents Documented Infesting Housing in Kansas, United States.

J Med Entomol 2021 May 19. Epub 2021 May 19.

Naval Medical Research Center, Viral and Rickettsial Diseases Department, Silver Spring, MD, USA.

During September-December 2018, 25 live ticks were collected on-post at Fort Leavenworth, Kansas, in a home with a history of bat occupancy. Nine ticks were sent to the Army Public Health Center Tick-Borne Disease Laboratory and were identified as Carios kelleyi (Cooley and Kohls, 1941), a species that seldom bites humans but that may search for other sources of blood meals, including humans, when bats are removed from human dwellings. The ticks were tested for numerous agents of human disease. Read More

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The "One Mind, Two Aspects" Model of the Self: The Self Model and Self-Cultivation Theory of Chinese Buddhism.

Kai Wang

Front Psychol 2021 28;12:652465. Epub 2021 Apr 28.

Department of Philosophy, Nanjing University, Nanjing, China.

Constructing a self model with universal cultural adaptability is a common concern of cultural psychologists. These models can be divided into two types: one is the self model based on Western culture, represented by the self theory of Marsh, Cooley, Fitts, etc.; the other is the non-self model based on Eastern culture, represented by the Mandela model of Hwang Kwang Kuo and the Taiji model of Zhen Dong Wang. Read More

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Infusion reactions in natural killer cell immunotherapy: a retrospective review.

Cytotherapy 2021 Jul 9;23(7):627-634. Epub 2021 May 9.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address:

Background Aims: The use of natural killer (NK) cells as a cellular immunotherapy has increased over the past decade, specifically in patients with hematologic malignancies. NK cells have been used at the authors' institution for over 15 years. Most patients have a reaction to NK cell infusion. Read More

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Crowdsourced Tick Image-Informed Updates to U.S. County Records of Three Medically Important Tick Species.

J Med Entomol 2021 May 11. Epub 2021 May 11.

Department of Plant Sciences and Entomology, University of Rhode Island, Kingston, RI, USA.

Burgeoning cases of tick-borne disease present a significant public health problem in the United States. Passive tick surveillance gained traction as an effective way to collect epidemiologic data, and in particular, photograph-based tick surveillance can complement in-hand tick specimen identification to amass distribution data and related encounter demographics. We compared the Federal Information Processing Standards (FIPS) code of tick photos submitted to a free public identification service (TickSpotters) from 2014 to 2019 to published nationwide county reports for three tick species of medical concern: Ixodes scapularis Say (Ixodida: Ixodidae), Ixodes pacificus Cooley and Kohls (Ixodida: Ixodidae), and Amblyomma americanum Linneaus (Ixodida: Ixodidae). Read More

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A Systematic Review of the Effect of Physical Activity on Asthma Outcomes.

J Allergy Clin Immunol Pract 2021 May 6. Epub 2021 May 6.

Department of Medicine, University of Illinois at Chicago, Chicago, Ill. Electronic address:

Background: Asthma is a chronic respiratory disease that affects millions worldwide. Medication management is the current mainstay of treatment; however, there is evidence to suggest additional benefit with lifestyle changes, particularly with increased physical activity.

Objective: To discover and evaluate the effects of physical activity on asthma outcomes. Read More

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Detection of Genetic Variability in Borrelia miyamotoi (Spirochaetales: Spirochaetaceae) Between and Within the Eastern and Western United States.

J Med Entomol 2021 May 6. Epub 2021 May 6.

Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.

Borrelia miyamotoi is a hard tick-associated relapsing fever spirochete that is geographically widespread in Ixodes spp. (Acari: Ixodidae) ticks, but typically occurs at low prevalence. Genetic variability has been described among strains derived from Asia, Europe, and North America, and among tick species that carry the infection, but little variability has been described within foci or tick species. Read More

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No Serological Evidence of Trachoma or Yaws Among Residents of Registered Camps and Makeshift Settlements in Cox's Bazar, Bangladesh.

Am J Trop Med Hyg 2021 May 3. Epub 2021 May 3.

1Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.

Successful achievement of global targets for elimination of trachoma as a public health problem and eradication of yaws will require control efforts to reach marginalized populations, including refugees. Testing for serologic evidence of transmission of trachoma and yaws in residents of registered camps and a Makeshift Settlement in Cox's Bazar District, Bangladesh, was added to a serosurvey for vaccine-preventable diseases (VPDs) conducted April-May 2018. The survey was primarily designed to estimate remaining immunity gaps for VPDs, including diphtheria, measles, rubella, and polio. Read More

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Fostering Healthy Futures Preventive Intervention for Children in Foster Care: Long-term Delinquency Outcomes from a Randomized Controlled Trial.

Prev Sci 2021 Apr 27. Epub 2021 Apr 27.

Colorado State Court Administrator's Office, 1300 Broadway UNIT 1200, Denver, CO, 80203, USA.

Child maltreatment and foster care placement are strong risk factors for delinquency and juvenile justice involvement, and there is substantial crossover between youth in the child welfare and juvenile justice systems. This study examines the long-term impact of the Fostering Healthy Futures (FHF) program, a 30-week mentoring and skills group preventive intervention for preadolescent maltreated children in foster care. Participants included 426 children recently placed in out-of-home care who were randomized to intervention or control conditions. Read More

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A Qualitative Study of Nurses' Perceptions of Narcotic Administration after Subarachnoid Hemorrhage.

Pain Manag Nurs 2021 Apr 23. Epub 2021 Apr 23.

University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Nearly every patient admitted to a neuroscience intensive care unit (ICU) will experience pain and nurses are tasked with analgesic administration. Within the setting of the ongoing opioid epidemic it is not well understood how nurses meet the need to alleviate pain while individualizing analgesic administration.

Aims: This qualitative study used a phenomenological approach to determine nurses' perceptions in pain management of patientswith subarachnoid hemorrhage (SAH). Read More

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Endosperm-based incompatibilities in hybrid monkeyflowers.

Plant Cell 2021 Apr 24. Epub 2021 Apr 24.

Biology Department, College of William and Mary, Williamsburg, 23185, USA.

Endosperm is an angiosperm innovation central to their reproduction whose development, and thus seed viability, is controlled by genomic imprinting, where expression from certain genes is parent-specific. Unsuccessful imprinting has been linked to failed inter-specific and inter-ploidy hybridization. Despite their importance in plant speciation, the underlying mechanisms behind these endosperm-based barriers remain poorly understood. Read More

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A pilot study of the acceptability, feasibility and safety of yoga for chronic pain in sickle cell disease.

Complement Ther Med 2021 Jun 21;59:102722. Epub 2021 Apr 21.

Division of Pediatric Hematology-Oncology-BMT, Department of Pediatrics, Emory University, Atlanta, GA, USA; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, USA.

Objectives: To determine the acceptability, feasibility and safety of yoga for chronic pain in sickle cell disease.

Design And Setting: In Part A of this two-part study, adolescents with SCD and chronic pain (Group 1) and their parent (Group 2) completed a survey designed to capture pain characteristics, attitudes and practices related to yoga, and potential acceptability of a yoga program. In Part B, the study assessed the feasibility and safety of an instructor-led group yoga program. Read More

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Genetic rearrangement during site specific integration event facilitates cell line development of a bispecific molecule.

Biotechnol Prog 2021 Apr 23:e3158. Epub 2021 Apr 23.

Cell Line Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts, USA.

Site specific integration (SSI) expression systems offer robust means of generating highly productive and stable cell lines for traditional monoclonal antibodies. As complex modalities such as antibody-like molecules comprised of greater than two peptides become more prevalent, greater emphasis needs to be placed on the ability to produce appreciable quantities of the correct product of interest (POI). The ability to screen several transcript stoichiometries could play a large role in ensuring high amounts of the correct POI. Read More

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A Serum Proteomic Signature Predicting Survival in Patients with Glioblastoma.

J Biochem Anal Stud 2020 Mar 26;4(1). Epub 2019 Oct 26.

Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland USA.

Purpose: Glioblastoma (GBM) is the most common form of brain tumor and has a uniformly poor prognosis. Development of prognostic biomarkers in easily accessible serum samples have the potential to improve the outcomes of patients with GBM through personalized therapy planning.

Material/methods: In this study pre-treatment serum samples from 30 patients newly diagnosed with GBM were evaluated using a 40-protein multiplex ELISA platform. Read More

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Femoral hernias: A paediatric surgical enigma.

J Pediatr Surg 2021 Mar 24. Epub 2021 Mar 24.

Children's Health Ireland at Crumlin, Cooley Rd, Crumlin D12 N512, Dublin, Ireland; Children's Health Ireland at Tallaght, Tallaght University Hospital, Tallaght D24 NR0A, Dublin, Ireland.

Purpose: In the paediatric population, femoral hernia (FH) represents an uncommon and often misdiagnosed pathology. This study aimed to review our experience with the management of FH in children.

Methods: Medical records were retrospectively reviewed for all patients presenting to the paediatric surgical service in Ireland over a 15-year period (2004-2019), who were operated on for FH. Read More

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A Comparison of Questing Substrates and Environmental Factors That Influence Nymphal Ixodes pacificus (Acari: Ixodidae) Abundance and Seasonality in the Sierra Nevada Foothills of California.

J Med Entomol 2021 Apr 16. Epub 2021 Apr 16.

California Department of Public Health-Vector-Borne Disease Section, Sacramento, CA, USA.

In California, the western blacklegged tick, Ixodes pacificus Cooley and Kohls, is the principal vector of the Borrelia burgdorferi sensu lato (sl) complex (Spirochaetales: Spirochaetaceae, Johnson et al.), which includes the causative agent of Lyme disease (B. burgdorferi sensu stricto). Read More

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Demographic, clinical, and epidemiologic characteristics of persons under investigation for Coronavirus Disease 2019-United States, January 17-February 29, 2020.

PLoS One 2021 15;16(4):e0249901. Epub 2021 Apr 15.

CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Background: The Coronavirus Disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), evolved rapidly in the United States. This report describes the demographic, clinical, and epidemiologic characteristics of 544 U.S. Read More

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