192,436 results match your criteria Conversion Disorders


Gluconeogenesis is essential for trypanosome development in the tsetse fly vector.

PLoS Pathog 2018 Dec 17;14(12):e1007502. Epub 2018 Dec 17.

Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), Université de Bordeaux, CNRS UMR-5234, Bordeaux, France.

In the glucose-free environment that is the midgut of the tsetse fly vector, the procyclic form of Trypanosoma brucei primarily uses proline to feed its central carbon and energy metabolism. In these conditions, the parasite needs to produce glucose 6-phosphate (G6P) through gluconeogenesis from metabolism of non-glycolytic carbon source(s). We showed here that two phosphoenolpyruvate-producing enzymes, PEP carboxykinase (PEPCK) and pyruvate phosphate dikinase (PPDK) have a redundant function for the essential gluconeogenesis from proline. Read More

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December 2018

Energy Flux Manipulation in Upconversion Nanosystems.

Acc Chem Res 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemistry, Faculty of Science , National University of Singapore , Singapore 117543.

Lanthanide-doped upconversion nanoparticles (UCNPs) exhibit unique optical characteristics, including a large anti-Stokes shift, a long luminescence lifetime, sharp emission bands, and high photostability. These virtues make UCNPs highly useful in many emerging applications such as biolabeling, security, multicolor displays, and optogenetics. Despite the enticing prospects of UCNPs, their practical utility is greatly hindered by the low efficiency of the conversion from near-infrared (NIR) excitation to visible emission. Read More

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December 2018

Solubilization of Carbon Nanotubes with Ethylene-Vinyl Acetate for Solution-Processed Conductive Films and Charge Extraction Layers in Perovskite Solar Cells.

ACS Appl Mater Interfaces 2018 Dec 17. Epub 2018 Dec 17.

Department of Physics, Clarendon Laboratory , University of Oxford , Parks Road , Oxford OX1 3PU , U.K.

Carbon nanotube (CNT) solubilization via non-covalent wrapping of conjugated semiconducting polymers is a common technique used to produce stable dispersions for depositing CNTs from solution. Here, we report the use of a non-conjugated insulating polymer, ethylene vinyl acetate (EVA), to disperse multi- and single-walled CNTs (MWCNT and SWCNT) in organic solvents. We demonstrate that despite the insulating nature of the EVA, we can produce semitransparent films with conductivities of up to 34 S/cm. Read More

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December 2018

Armeniaspirol antibiotic biosynthesis: Chlorination and oxidative dechlorination steps affording spiro[4.4]non-8-ene formation.

Chembiochem 2018 Dec 17. Epub 2018 Dec 17.

Helmholtz-Institute for Pharmaceutical Research Saarland, Microbial Natural Products, Campus Building C2.3, 66123, Saarbrücken, GERMANY.

Armeniaspirols are potent antibiotics containing an unusual spiro[4.4]non-8-ene moiety. We describe the cloning and functional analysis of the armeniaspirol biosynthetic gene cluster. Read More

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December 2018

Lycophyte plastid genomics: extreme variation in GC, gene and intron content and multiple inversions between a direct and inverted orientation of the rRNA repeat.

New Phytol 2018 Dec 17. Epub 2018 Dec 17.

Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, 48109, USA.

Lycophytes are a key group for understanding vascular plant evolution. Lycophyte plastomes are highly distinct, indicating a dynamic evolutionary history, but detailed evaluation is hindered by the limited availability of sequences. Eight diverse plastomes were sequenced to assess variation in structure and functional content across lycophytes. Read More

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December 2018

Theoretical insights into photo-induced electron transfer at BiOX (X = F, Cl, Br, I) (001) surfaces and interfaces.

Phys Chem Chem Phys 2018 Dec 17. Epub 2018 Dec 17.

State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, China.

The electron transfer process (ETP) of a photocatalyst plays a crucial role in clarifying its photoelectrochemical catalytic mechanism. BiOX (X = F, Cl, Br, I) (001) surfaces display excellent photocatalytic performance due to the high separation efficiency of photogenerated electron-hole (e--h+) pairs in their own efficient internal electric field (IEF). The oxygen vacancies (OVs) on the surfaces could cause a change in localized electronic states, then improve the photocatalytic activity of BiOX. Read More

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December 2018

Real-world outcomes post-transition to once-every-three-month paliperidone palmitate in patients with schizophrenia within US commercial plans.

Curr Med Res Opin 2018 Dec 17. Epub 2018 Dec 17.

b Janssen Scientific Affairs, LLC , Titusville , NJ , 08560 , USA.

Objectives: To compare comorbidity-related outcomes, adherence to APs, healthcare resource utilization (HRU), and costs pre- and post-transition to once-every-three-month paliperidone palmitate (PP3M) in commercially-insured patients with schizophrenia.

Methods: Adults with ≥1 claim for PP3M, ≥2 schizophrenia diagnoses, and adequate treatment with once-monthly paliperidone palmitate (PP1M; i.e. Read More

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December 2018

4"-O-Alkylated α-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies.

ChemMedChem 2018 Dec 17. Epub 2018 Dec 17.

Laboratory for Medicinal Chemistry, Department of Pharmaceutics (FFW), Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.

Invariant natural killer T-cells (iNKT) are a glycolipid-responsive subset of T-lymphocytes that fulfill a pivotal role in the immune system. The archetypical synthetic glycolipid, α-galactosylceramide (α-GalCer), whose molecular framework is inspired by a group of amphiphilic natural products, remains the most studied antigen for iNKT-cells. Nonetheless, the potential of α-GalCer as an immunostimulating agent is compromised by the fact that this glycolipid elicits simultaneous secretion of Th1- and Th2-cytokines. Read More

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December 2018

Surface and interface design for heterogeneous catalysis.

Phys Chem Chem Phys 2018 Dec 17. Epub 2018 Dec 17.

Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Materials for Energy Conversion of Chinese Academy of Sciences, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, P. R. China.

Surface and interface designs are an efficient strategy to fabricate innovative and advanced catalysts. A prerequisite for this is a fundamental understanding of the structure-performance relations of catalyst nanoparticles, which, however, remains a formidable challenge due to the complexity of heterogeneous catalysis. Recent progresses in catalytic nanocrystals with uniform and well-defined structures, in situ characterization techniques, and theoretical calculations have offered opportunities for the fundamental studies of heterogeneous catalysis, and the achieved outputs are turning the innovation of efficient catalysts via surface and interface designs into a reality. Read More

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December 2018

Facile Conversion of syn-[FeIV(O)(TMC)]2+ to its anti Isomer via Meunier's Oxo-Hydroxo Tautomerism Mechanism.

Angew Chem Int Ed Engl 2018 Dec 16. Epub 2018 Dec 16.

University of Minnesota Twin Cities, Chemistry, 207 Pleasant St. SE, 55455, Minneapolis, UNITED STATES.

The syn and anti isomers of [FeIV(O)(TMC)]2+ (TMC = tetramethylcyclam) represent the first isolated pair of synthetic non-heme oxoiron(IV) complexes with the identical ligand topology and differing only in the position of the oxo unit bound to the iron center. Both isomers have previously been characterized by X-ray crystallography and various spectroscopic techniques. Herein we report that the syn isomer [FeIV(Osyn)(TMC)(NCMe)]2+ (2) converts to its anti form [FeIV(Oanti)(TMC)(NCMe)]2+ (1) in MeCN solution, an isomerization facilitated by water and monitored most readily by 1H-NMR and Raman spectroscopy. Read More

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December 2018

Broadband Cr3+, Sn4+-doped Oxide Nanophosphors for Infrared Mini Light-Emitting Diodes.

Angew Chem Int Ed Engl 2018 Dec 16. Epub 2018 Dec 16.

National Taiwan University, Department of Chemistry, No. 1, Sec. 4, Roosevelt Road, 106, Taipei, TAIWAN.

Light-emitting diode breaks barriers of size and performance for display. With the device getting smaller, the materials need to get smaller. However, Chromium(III)-doped oxide phosphors, which emit near-infrared (NIR) light, have recently been used in small electronic devices. Read More

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December 2018

A High Current Density Direct-Current Generator Based on a Moving van der Waals Schottky Diode.

Adv Mater 2018 Dec 17:e1804398. Epub 2018 Dec 17.

College of microelectronics, College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, 310027, P. R. China.

Traditionally, Schottky diodes are used statically in the electronic information industry while dynamic or moving Schottky diode-based applications are rarely explored. Herein, a novel Schottky diode named "moving Schottky diode generator" is designed, which can convert mechanical energy into electrical energy by means of lateral movement between the graphene/metal film and semiconductor. The mechanism is based on the built-in electric field separation of the diffusing carriers in moving Schottky diode. Read More

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December 2018

Highly Flexible Electrospun Hybrid (Polyurethane/Dextran/Pyocyanin) Membrane for Antibacterial Activity via Generation of Oxidative Stress.

ACS Omega 2018 Nov 1;3(11):14551-14561. Epub 2018 Nov 1.

Department of Forest Science and Technology, College of Agriculture and Life Sciences, and Department of Animal Biotechnology, College of Agriculture and Life Sciences, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si 561-756, Jeollabuk-do, Republic of Korea.

A hybrid nanofibrous mat consisting of polyurethane, dextran, and 10 wt % of biopigment (i.e., pyocyanin) was facilely fabricated using a direct-conventional electrospinning method. Read More

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November 2018

In situ recombination junction between p-Si and TiO enables high-efficiency monolithic perovskite/Si tandem cells.

Sci Adv 2018 Dec 14;4(12):eaau9711. Epub 2018 Dec 14.

Centre for Sustainable Energy Systems, Research School of Engineering, The Australian National University, Canberra 2601, Australia.

Increasing the power conversion efficiency of silicon (Si) photovoltaics is a key enabler for continued reductions in the cost of solar electricity. Here, we describe a two-terminal perovskite/Si tandem design that increases the Si cell's output in the simplest possible manner: by placing a perovskite cell directly on top of the Si bottom cell. The advantageous omission of a conventional interlayer eliminates both optical losses and processing steps and is enabled by the low contact resistivity attainable between n-type TiO and Si, established here using atomic layer deposition. Read More

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December 2018

Extraordinary Focusing Effect of Surface Nanolenses in Total Internal Reflection Mode.

ACS Cent Sci 2018 Nov 19;4(11):1511-1519. Epub 2018 Oct 19.

Department of Electrical & Computer Engineering and Department of Chemical & Materials Engineering, University of Alberta, Edmonton T6G1H9, Alberta, Canada.

Microscopic lenses are paramount in solar energy harvesting, optical devices, and imaging technologies. This work reports an extraordinary focusing effect exhibited by a surface nanolens (i.e. Read More

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November 2018

Hydrodeoxygenation of Isoeugenol over Alumina-Supported Ir, Pt, and Re Catalysts.

ACS Sustain Chem Eng 2018 Dec 15;6(12):16205-16218. Epub 2018 Oct 15.

Johan Gadolin Process Chemistry Centre, Åbo Akademi University, Turku, Finland.

Hydrodeoxygenation (HDO) of isoeugenol (IE) was investigated using bimetallic iridium-rhenium and platinum-rhenium catalysts supported on alumina in the temperature and pressure ranges of 200-250 °C and 17-40 bar in nonpolar dodecane as a solvent. The main parameters were catalyst type, hydrogen pressure, and initial concentration. Nearly quantitative yield of the desired product, propylcyclohexane (PCH), at complete conversion in 240 min was obtained with Ir-Re/AlO prepared by the deposition-precipitation method using 0. Read More

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December 2018

Patients with RAS wild-type right-sided unresectable liver-confined mCRC also benefit from cetuximab plus chemotherapy in first-line treatment.

Am J Cancer Res 2018 1;8(11):2337-2345. Epub 2018 Nov 1.

Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, People's Republic of China.

Growing evidence indicates that primary tumor location of metastatic colorectal cancer (mCRC) can affect response to specific therapy. This study aimed to assess the impact of primary tumor location on efficacy of cetuximab in Chinese patients with mCRC. We included patients with RAS wild-type liver-limited mCRC treated with first-line cetuximab plus chemotherapy or chemotherapy alone between June 2008 and December 2016. Read More

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November 2018

Conversion of Sugars and Biomass to Furans Using Heterogeneous Catalysts in Biphasic Solvent Systems.

ChemCatChem 2018 Nov 13;10(21):4805-4816. Epub 2018 Sep 13.

Department of Chemical and Biological Engineering Montana State University Bozeman 59717-2220 MT USA.

Within the last decade, interest in using biphasic systems for producing furans from biomass has grown significantly. Biphasic systems continuously extract furans into the organic phase, which prevents degradation reactions and potentially allows for easier separations of the products. Several heterogeneous catalyst types, including zeolites, ion exchange resins, niobium-based, and others, have been used with various organic solvents to increase furan yields from sugar dehydration reactions. Read More

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November 2018

Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy.

Theranostics 2018 10;8(20):5662-5675. Epub 2018 Nov 10.

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P. R. China.

Currently, a large number of anti-tumor drug delivery systems have been widely used in cancer therapy. However, due to the molecular complexity and multidrug resistance of tumors, monotherapies remain suboptimal. Thus, this study aimed to develop a multifunctional theranostic nanoplatform for effective cancer therapy. Read More

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November 2018

A Biomimetic Gold Nanocages-Based Nanoplatform for Efficient Tumor Ablation and Reduced Inflammation.

Theranostics 2018 24;8(19):5362-5378. Epub 2018 Oct 24.

National Engineering Research Center for Nanomedicine, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

Gold nanocages (AuNCs), with high photothermal conversion efficiency and unique hollow interiors, have become a promising nanoplatform for synergistic phototheraml therapy (PTT)-chemotherapy. However, the insufficient tumor targeting, in vivo premature drug leakage and low drug loading efficiency responsible for the spatial-temporal un-synchronization of PTT-chemotherapy, as well as inflammatory response might compromise the anticancer treatment of AuNCs-based drug delivery systems. Cancer cell membrane (CCM)-coated AuNCs were developed to load anticancer drug doxorubicin (DOX@CAuNCs) by transmembrane ammonium sulfate gradient method. Read More

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October 2018

In silico-designed lignin peroxidase from shows enhanced acid stability for depolymerization of lignin.

Biotechnol Biofuels 2018 10;11:325. Epub 2018 Dec 10.

1School of Energy and Chemical Engineering, UNIST, 50 UNIST-gil, Ulju-gun, Ulsan, 44919 Republic of Korea.

Background: The lignin peroxidase isozyme H8 from the white-rot fungus (LiPH8) demonstrates a high redox potential and can efficiently catalyze the oxidation of veratryl alcohol, as well as the degradation of recalcitrant lignin. However, native LiPH8 is unstable under acidic pH conditions. This characteristic is a barrier to lignin depolymerization, as repolymerization of phenolic products occurs simultaneously at neutral pH. Read More

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December 2018

Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments.

Front Immunol 2018 29;9:2789. Epub 2018 Nov 29.

Department of Oral Biology, University of Florida, Gainesville, FL, United States.

Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to xanthosine monophosphate, the rate-limiting step in guanosine monophosphate (GMP) synthesis. In cultured cells, IMPDH polymerizes into micron-scale filamentous structures when GMP synthesis is inhibited by depletion of purine precursors or by various drugs, including mycophenolic acid, ribavirin, and methotrexate. IMPDH filaments also spontaneously form in undifferentiated mouse embryonic stem cells and induced pluripotent stem cells, hinting they might function in various highly proliferative cell types. Read More

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November 2018

Ammonia Inhibition of Anaerobic Volatile Fatty Acid Degrading Microbial Communities.

Front Microbiol 2018 30;9:2921. Epub 2018 Nov 30.

Department of Environmental Microbiology, UFZ-Helmholtz Center for Environmental Research, Leipzig, Germany.

Ammonia inhibition is an important reason for reactor failures and economic losses in anaerobic digestion. Its impact on acetic acid degradation is well-studied, while its effect on propionic and butyric acid degradation has received little attention and is consequently not considered in the Anaerobic Digestion Model No. 1 (ADM1). Read More

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November 2018

Carbonized Cow Dung as a High Performance and Low Cost Anode Material for Bioelectrochemical Systems.

Front Microbiol 2018 30;9:2760. Epub 2018 Nov 30.

Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling, School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou, China.

We develop a high-performance anode formed from carbonized cow dung for bioelectrochemical systems. Thermal gravimetric analysis showed that the CD carbonization process started at 300°C and ended at approximately 550°C; the weight was reduced by 51%. After a heat-treatment at 800°C for 2 h, the treated CD featured a good conductivity and a high specific surface area. Read More

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November 2018

Potentials of Cellular Reprogramming as a Novel Strategy for Neuroregeneration.

Front Cell Neurosci 2018 30;12:460. Epub 2018 Nov 30.

Centre for Eye Research Australia, East Melbourne, VIC, Australia.

Cellular reprogramming technology holds great potential for tissue repair and regeneration to replace cells that are lost due to diseases or injuries. In addition to the landmark discovery of induced pluripotent stem cells, advances in cellular reprogramming allow the direct lineage conversion of one somatic cell type to another using defined transcription factors. This direct reprogramming technology represents a rapid way to generate target cells in the laboratory, which can be used for transplantation and studies of biology and diseases. Read More

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November 2018

Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy.

Int J Nanomedicine 2018 29;13:8119-8135. Epub 2018 Nov 29.

Beijing Key Laboratory of Molecular Pharmaceutics and New Drug System, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China,

Background: The existing chemo/radiotherapy fail to eliminate cancer cells due to the restriction of either drug resistance or radio tolerance. The predicament urges researchers to continuously explore alternative strategy for achieving a potent curative effect.

Methods: Functional chlorin gold nanorods (Ce6-AuNR@SiO-d-CPP) were fabricated aiming at treating breast cancer by photothermal/photodynamic therapy (PTT/PDT). Read More

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November 2018

WHERE HAS ALL THE POWER GONE? ENERGY PRODUCTION AND LOSS IN VOCALIZATION.

Authors:
Ingo R Titze

Speech Commun 2018 Jul 16;101:26-33. Epub 2018 May 16.

National Center for Voice and Speech, The University of Utah, Salt Lake City, UT.

Human voice production for speech is an inefficient process in terms of energy expended to produce acoustic output. A traditional measure of vocal efficiency relates acoustic power radiated from the mouth to aerodynamic power produced in the trachea. This efficiency ranges between 0. Read More

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Ultrasound-assisted biodiesel production using heterogeneous base catalyst and mixed non-edible oils.

Ultrason Sonochem 2018 Dec 4. Epub 2018 Dec 4.

Center for Energy, Indian Institute of Technology Guwahati, Assam 781 039, India; Department of Chemical Engineering, Indian Institute of Technology Guwahati, Assam 781 039, India. Electronic address:

In the present study, the ultrasound-assisted biodiesel production from mixed feedstock of non-edible oils in presence of KI impregnated ZnO as a catalyst in batch reactor was investigated. The production was optimized by using two approaches (1) feedstock optimization and (2) process parameters optimization. Various non-edible oils at optimum volumetric ratio were blended and used as feedstock for transesterification reaction. Read More

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December 2018

Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood.

Dev Cell 2018 Dec 10. Epub 2018 Dec 10.

Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112-5330, USA. Electronic address:

Animals must adjust their metabolism as they progress through development in order to meet the needs of each stage in the life cycle. Here, we show that the dHNF4 nuclear receptor acts at the onset of Drosophila adulthood to direct an essential switch in lipid metabolism. Lipid stores are consumed shortly after metamorphosis but contribute little to energy metabolism. Read More

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December 2018

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.

Cell Stem Cell 2018 Dec 10. Epub 2018 Dec 10.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, Israel. Electronic address:

The epigenetic dynamics of induced pluripotent stem cell (iPSC) reprogramming in correctly reprogrammed cells at high resolution and throughout the entire process remain largely undefined. Here, we characterize conversion of mouse fibroblasts into iPSCs using Gatad2a-Mbd3/NuRD-depleted and highly efficient reprogramming systems. Unbiased high-resolution profiling of dynamic changes in levels of gene expression, chromatin engagement, DNA accessibility, and DNA methylation were obtained. Read More

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December 2018

Cost-effectiveness modelling studies of all preventive measures against rabies: A systematic review.

Vaccine 2018 Dec 13. Epub 2018 Dec 13.

Health Technology Assessment Postgraduate Program, Mahidol University, 447 Sri-Ayuthaya Road, Phaya Thai, Ratchathewi, Bangkok 10400, Thailand; Social Administrative Pharmacy Excellence Research (SAPER) Unit, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayuthaya Road, Phaya Thai, Ratchathewi, Bangkok 10400, Thailand. Electronic address:

Rabies is one of the most feared infectious diseases worldwide, predominantly occurring in Asia and Africa where rabies is endemic in domestic dog populations. Whereas previous studies have demonstrated mass dog vaccination and post-exposure prophylaxis (PEP) as the most effective control strategies, successful rabies elimination has yet to be realized as these recognized effective interventions continue to face challenges of limited accessibility. In the light of new evidence towards improving programmatic feasibility and clinical practice in rabies control especially among endemic countries, a systematic review was undertaken to identify cost-effectiveness modelling studies of rabies preventive measures and to provide a critical review of published evidence through comparative evaluation and model quality assessment, and a synthesis of key findings based thereon. Read More

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December 2018

Convenient preparation of sagittatoside B, a rare bioactive secondary flavonol glycoside, by recyclable and integrated biphase enzymatic hydrolysis.

Enzyme Microb Technol 2019 Feb 3;121:51-58. Epub 2018 Dec 3.

School of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China. Electronic address:

Sagittatoside B, a rare secondary flavonol glycoside in Epimedii Folium, has much better in vivo bioactivities than its original glycoside epimedin B. Its preparation methods, such as acidic hydrolysis, are of low efficiency, and byproducts are generated. The objective of this study was to establish a novel catalysis system for convenient preparation of this compound based on recyclable and integrated biphase enzymatic hydrolysis. Read More

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February 2019

Type-1 interferons prolong the lifespan of neutrophils by interfering with members of the apoptotic cascade.

Cytokine 2018 Dec 7;112:21-26. Epub 2018 Jul 7.

Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck 23538, Germany. Electronic address:

Polymorphonuclear Neutrophils (PMNs) are metabolically highly active phagocytes, present in abundant numbers in the circulation. These active cells take the onus of clearing invading pathogens by crowding at inflammatory sites in huge numbers. Though PMNs are extremely short living and die upon spontaneous apoptosis, extended lifespan has been observed among those cells arrive at the inflammation sites or tackle intracellular infections or face any microbial challenges. Read More

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December 2018

Stable Bandgap-Tunable Hybrid Perovskites with Alloyed Pb-Ba Cations for High-Performance Photovoltaic Applications.

J Phys Chem Lett 2018 Dec 16. Epub 2018 Dec 16.

The intrinsic poor stability of methylammonium lead triiodide (MAPbI3) perovskite in the ambient environment remains as the major challenge for photovoltaic and optoelectronic applications. In this work, complimentary first-principles calculations and experimental characterizations reveal that hybrid perovskites with alloyed metal cations (MABaxPb1-xI3) can be synthesized and exhibit substantially enhanced hydrolytic stability via forming stronger bonds between halide and Ba ions. The alloyed Ba-Pb perovskites remain phase pure in ambient air for more than 15 days. Read More

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December 2018

The role of robotic aortic lymphadenectomy in gynecological cancer: surgical and oncological outcome in a single institution experience.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

Division of Gynecologic Oncology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background And Objective: This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients.

Methods: Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, including transperitoneal AL, between December 2014 and February 2018 at the Catholic University of the Sacred Heart, Rome, Italy.

Results: Median age of the sample population was 50 years (range, 26-76 years). Read More

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December 2018

Recent advances in metalloporphyrins for environmental and energy applications.

Chemosphere 2018 Dec 4;219:617-635. Epub 2018 Dec 4.

School of Environmental Science and Engineering, Huazhong University of Science and Technology (HUST), Wuhan, Hubei, 430074, PR China; Hubei Provincial Engineering Laboratory of Solid Waste Treatment, Disposal and Recycling, Huazhong University of Science and Technology (HUST), Wuhan, Hubei, 430074, PR China. Electronic address:

Porphyrin-based chemistry has reached an unprecedented period of rapid development after decades of study. Due to attractive multifunctional properties, porphyrins and their analogues have emerged as multifunctional organometals for environmental and energy purposes. In particular, pioneer works have been conducted to explore their application in pollution abatement, energy conversion and storage and molecule recognition. Read More

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December 2018

Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells.

Biomaterials 2018 Dec 6;193:30-46. Epub 2018 Dec 6.

Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea. Electronic address:

Use of stem cells in regenerative medicine holds great promise in treating people suffering from various otherwise incurable ailments. Direct conversion of somatic cells to other lineages thereby bypassing the intermediate pluripotent state has enormous applicability with respect to time requirement for conversion as well as safety issues. Among various approaches, chemical induced cell conversion is safe yet effective, and the use of small molecules has thus increased greatly in recent years in regenerative fields due to easy applicability, efficient scalability, and consistent reproducibility. Read More

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December 2018

Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D.

J Steroid Biochem Mol Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. Electronic address:

Calcitroic acid, the excretory form of vitamin D, is the terminal product of a 5-step pathway catalyzed by CYP24A1, commencing with C24-hydroxylation of 1,25-dihydroxyvitamin D (1,25-(OH)D). Catabolism of 25-hydroxyvitamin D (25-OH-D) proceeds via analogous steps culminating in calcioic acid; however this C23-truncated acid has not been reported in the circulation. It has recently been shown that 24,25-dihydroxyvitamin D (24,25-(OH)D) is an important factor in optimal bone fracture healing acting via an effector molecule FAM57B2 to produce lactosylceramide. Read More

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December 2018

Ganglioside synthase knock-out reduces prion disease incubation time in mouse models.

Am J Pathol 2018 Dec 13. Epub 2018 Dec 13.

Department of Laboratory Animal Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

Localization of the abnormal and normal isoforms of prion proteins to detergent-resistant membrane microdomains, lipid rafts, is important for the conformational conversion. Lipid rafts are enriched in sialic acid-containing glycosphingolipids, namely gangliosides. Alteration in the ganglioside composition of lipid rafts can affect the localization of lipid raft-associated proteins. Read More

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December 2018
1 Read

Enantioselective synthesis of enantiopure β-amino alcohols via kinetic resolution and asymmetric reductive amination by a robust transaminase from Mycobacterium vanbaalenii.

J Biotechnol 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China.

Chiral β-amino alcohols are very important chiral building block for preparing bioactive compounds for use in pharmaceutical and fine chemical industries. Synthesis of chiral β-amino alcohols by transaminase is big challenging due to the strict substrate specificities and very low activity of the enzyme. In this work, a (R)-selective ω-transaminase (MVTA) from Mycobacterium vanbaalenii was employed as a biocatalyst for the first time for the synthesis of chiral β-amino alcohol via kinetic resolution and asymmetric reductive amination. Read More

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December 2018

Development of a novel, sensitive cell-based Corin Assay.

Biochem Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Lead Discovery Wuppertal, Bayer AG, Pharma Research and Development Center, Aprather Weg 18a, D-42096 Wuppertal, Germany. Electronic address:

Corin (atrial natriuretic peptide-converting enzyme, EC 3.4.21) is a transmembrane serine protease expressed in cardiomyocytes. Read More

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December 2018
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Prognosis of conversion of mild cognitive impairment to Alzheimer's dementia by voxel-wise Cox regression based on FDG PET data.

Neuroimage Clin 2018 Dec 10:101637. Epub 2018 Dec 10.

Department of Nuclear Medicine, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany; Center for Geriatrics and Gerontology Freiburg, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany.

Aim: The value of F-fluorodeoxyglucose (FDG) PET for the prognosis of conversion from mild cognitive impairment (MCI) to Alzheimer's dementia (AD) is controversial. In the present work, the identification of cerebral metabolic patterns with significant prognostic value for conversion of MCI patients to AD is investigated with voxel-based Cox regression, which in contrast to common categorical comparisons also utilizes time information.

Methods: FDG PET data of 544 MCI patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were randomly split into two equally-sized datasets (training and test). Read More

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December 2018

Automated and manual hippocampal segmentation techniques: Comparison of results, reproducibility and clinical applicability.

Neuroimage Clin 2018 Oct 14:101574. Epub 2018 Oct 14.

Department of Neurology, Indiana University, Indianapolis, IN, USA; Department of Radiological Sciences, Indiana University, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA. Electronic address:

Background: Imaging techniques used to measure hippocampal atrophy are key to understanding the clinical progression of Alzheimer's disease (AD). Various semi-automated hippocampal segmentation techniques are available and require human expert input to learn how to accurately segment new data. Our goal was to compare 1) the performance of our automated hippocampal segmentation technique relative to manual segmentations, and 2) the performance of our automated technique when provided with a training set from two different raters. Read More

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October 2018

Implications of secondary aortic intervention after thoracic endovascular aortic repair for acute and chronic type B dissection.

J Vasc Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.

Background: Thoracic endovascular aortic repair (TEVAR) has become a mainstay of therapy for acute and chronic type B aortic dissection (TBAD). Dynamic aortic morphologic changes, untreated dissected aorta, and persistent false lumen perfusion have significant consequences for reintervention after TEVAR for TBAD. However, few reports contrast differences in secondary aortic intervention (SAI) after TEVAR for TBAD or describe their influence on mortality. Read More

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December 2018

The group I GH3 family genes encoding JA-Ile synthetase act as positive regulator in the resistance of rice to Xanthomonas oryzae pv. oryzae.

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Plant GH3 genes are key components of the hormonal mechanism regulating growth and development, responding to biotic and abiotic stress. GH3 proteins are involved in hormonal homeostasis through conjugation to amino acids of the free form of salicylic acid, jasmonic acid (JA) or indole-3-acetic acid (IAA). Our previous work has uncovered that two GH3 genes encoding IAA-amido synthetase play important roles in the resistance to bacterial blight caused by Xanthomonas oryzae pv. Read More

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December 2018

Highly efficient hydrolysis of plant hemicelluloses by mixed-addenda Keggin-type (Mo-V-P)-heteropolyacids in diluted aqueous solution.

Carbohydr Polym 2019 Feb 31;206:80-85. Epub 2018 Oct 31.

University of Lisbon, School of Agriculture, Forest Research Center (CEF), Tapada da Ajuda, 1349-017, Lisbon, Portugal. Electronic address:

Polyoxometalate (POM) catalyzed hydrolysis of wood and agro-crop hemicelluloses by mixed-addenda molybdic α-Keggin-type heteropolyacids (HPAs), such as molybdovanadophosphate heteropolyacids (Mo-V-P)-HPAs of series H[PMoVO] with n = 3 and 4 (so-called HPA-3 and HPA-4), have been assessed in comparison with conventional sulfuric acid catalysis. In very diluted (20 mM) aqueous solutions of (Mo-V-P)-HPAs, up to 90% of total biomass xylan was readily converted into soluble sugars (mono and oligosaccharides) after 60 min hydrolysis reaction at 130 °C, vs only ca. 25% conversion (as a max. Read More

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February 2019

Efficient synthesis of organosoluble 6-azido-6-deoxy-2,3-O-trimethylsilyl cellulose for click reactions.

Carbohydr Polym 2019 Feb 3;206:174-178. Epub 2018 Nov 3.

Wood Technology and Wood Chemistry, University of Goettingen, Buesgenweg 4, 37077 Goettingen, Germany. Electronic address:

Huisgen cycloaddition has proven to be a powerful tool for the derivatization of cellulose, but the choice of reaction partners is limited by the solubility of the cellulose derivative. In this report, we show the efficient synthesis of an azide-bearing, organosoluble cellulose derivative via the 6-bromo-6-deoxy-2,3-O-trimethylsilyl cellulose (Br-TMSC) obtained through a novel one-pot reaction. It opens the possibility to perform the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) under moisture free conditions. Read More

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February 2019

Rotational spectroscopy of chiral tetrahydro-2-furoic acid: Conformational landscape, conversion, and abundances.

J Chem Phys 2018 Dec;149(22):224306

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

The conformational landscape of tetrahydro-2-furoic acid (THFA), a chiral carboxylic acid which is often used as a precursor in syntheses of pharmaceuticals, was investigated using rotational spectroscopy and theoretical modeling. Extensive manual searches were carried out to identify possible conformers related to the relative orientations of the carbonyl and hydroxyl groups in the COOH functional group, the COOH rotation, and the ring puckering motions in the system. A large number of initial conformational geometries were generated in parallel using a joint semiempirical-molecular dynamics simulation program. Read More

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December 2018

Simultaneous quantification of the degree of hydrolysis, protein conversion rate and mean molar weight of peptides released in the course of enzymatic proteolysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 6;1105:1-9. Epub 2018 Dec 6.

Laboratoire Réactions et Génie des Procédés, Université de Lorraine, CNRS, LRGP, F-54000 Nancy, France; Université de Lorraine, 2 Avenue de la forêt de Haye, F-54505 Vandœuvre-lès-Nancy, France. Electronic address:

This paper describes an original analytical methodology for a simultaneous measurement of the protein conversion rate, the mean molar weight of peptide and the degree of hydrolysis in the course of proteolysis by Size-Exclusion High-Performance Liquid Chromatography. Peak area of dead volume eluents reflects the non-converted protein. The protein conversion rate is thus determined by comparing the area at a given time to the initial area. Read More

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December 2018

A bifunctional conjugated polyelectrolyte for the interfacial engineering of polymer solar cells.

J Colloid Interface Sci 2018 Dec 7;538:611-619. Epub 2018 Dec 7.

Istituto per lo Studio delle Macromolecole (ISMac - CNR), Via Bassini 15, 20133 Milano, Italy. Electronic address:

In this work a novel combination of side chain functionalities, alkyl-phosphonate (EP) and alkyl-ammonium bromide (NBr) groups, on a polyfluorene backbone (PF-NBr-EP) was studied as cathode interfacial material (CIM) in polymer-based solar cells. The devices were made with a conventional geometry, with PTB7:PC BM as active layer and aluminum as metal electrode. The CIM showed good solubility in ethanol and film forming ability onto the active layer so that its deposition could be finely tuned. Read More

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December 2018