6,253 results match your criteria Conversion Disorder

Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia.

Mov Disord Clin Pract 2022 May 29;9(4):479-483. Epub 2022 Apr 29.

Amsterdam Neuroscience Amsterdam The Netherlands.

Background: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.

Methods: The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to define PD-MCI (n = 467). Read More

View Article and Full-Text PDF

Recent advances in understanding/management of premenstrual dysphoric disorder/premenstrual syndrome.

Fac Rev 2022 28;11:11. Epub 2022 Apr 28.

Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS San Matteo Foundation, Pavia, Italy.

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are common disorders of the luteal phase of the menstrual cycle and are characterized by moderate to severe physical, affective, or behavioral symptoms that impair daily activities and quality of life. PMS and PMDD have recently raised great interest in the research community for their considerable global prevalence. The etiology of PMS/PMDD is complex. Read More

View Article and Full-Text PDF

Ganser syndrome - a dissociative disorder or a factitious disorder? A case report.

Psychiatr Pol 2022 Feb 27;56(1):63-75. Epub 2022 Feb 27.

Warszawski Uniwersytet Medyczny, Katedra i Klinika Psychiatryczna.

Ganser syndrome (GS) is one of afew eponyms that have survived in psychiatry until the present day. GS is a little-known and rare disorder. It is most often described as a response to a stressor (e. Read More

View Article and Full-Text PDF
February 2022

Roles of m6A modification in neurological diseases.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Jan;47(1):109-115

Cancer Research Institute, Key Laboratory of Cancer Cellular and Molecular Pathology of Hunan Province, Hengyang Medical College, University of South China, Hengyang Hunan 421001.

N6-methyladenosine (m6A) methylation modification is one of the most common epigenetic modifications for eukaryotic mRNA. Under the catalytic regulation of relevant enzymes, m6A participates in the body's pathophysiological processes via mediating RNA transcription, splicing, translation, and decay. In the past, we mainly focused on the regulation of m6A in tumors such as hematological tumors, cervical cancer, breast cancer. Read More

View Article and Full-Text PDF
January 2022

Functional Disorders in Neurology and Gastroenterology: Notes on Terminology, Classification and Stigma.

Acta Med Port 2022 May 3. Epub 2022 May 3.

CHRC - Comprehensive Health Research Centre. NOVA Medical School. Universidade NOVA de Lisboa. Lisbon. Department of Neurology & Headache Centre. Hospital da Luz Lisboa. Lisbon. Department of Neurosciences and Mental Health. Hospital de Santa Maria. Centro Hospitalar Universitário Lisboa Norte. Lisbon. Portugal.

View Article and Full-Text PDF

Review/perspective on hysterical paralysis: A diagnosis of exclusion for spinal surgeons.

Nancy E Epstein

Surg Neurol Int 2022 29;13:172. Epub 2022 Apr 29.

Clinical Professor of Neurosurgery, School of Medicine, State University of NY at Stony Brook, NY and c/o Dr. Marc Agulnick 1122 Frankllin Avenue Suite 106, Garden City, NY 11530, USA.

Background: Hysterical paralysis (HP) and/or conversion disorders (CD) are diagnoses of exclusion for spine surgeons. Before assigning this diagnosis to a patient, they must first undergo a full neurodiagnostic evaluation (i.e. Read More

View Article and Full-Text PDF

Identification of a novel homozygous intron 3 splice site (A>T) mutation in the ARG1 gene in cerebral palsy pediatric cases from Odisha, India.

Mol Biol Rep 2022 May 3. Epub 2022 May 3.

School of Biotechnology, Kalinga Institute of Industrial Technology, KIIT Deemed to be University, Bhubaneswar, Odisha, India.

Background: Arginase enzyme is essential for the catalysis of the last step of the urea cycle, resulting in the conversion of L-arginine to L-ornithine and urea. Arginase deficiency could lead to hyperarginemia, an autosomal recessive disorder of the urea cycle that could result in developmental manifestations after the first year of life, followed by gradually progressive atonic cerebral palsy, spastic quadriplegia, and mental decline. ARG1 mutations have been reported in hyperarginemia patients of Western countries because they exhibited reduced arginase activity. Read More

View Article and Full-Text PDF

Exploring the influence of telehealth on patient engagement with a multidisciplinary Non-Epileptic Seizure (NES) Clinic during the COVID-19 pandemic.

Epilepsy Behav 2022 Jun 21;131(Pt A):108707. Epub 2022 Apr 21.

Department of Neurology, University of Colorado, Aurora, CO, USA.

The ILAE task force has identified a gap in treatment access for patients with nonepileptic seizures (NES) [1]. Access to multidisciplinary treatment clinics for adults with NES is limited with only 18 institutions delivering care across the United States [2]. Patient engagement has been low in the University of Colorado, NES Clinic treatment program despite our clinic's status as the only clinic of its kind in the mountain west. Read More

View Article and Full-Text PDF

A Shift in Approach: Assessment and Treatment of Adults With Functional Neurological Disorder.

J Health Serv Psychol 2022 28;48(2):79-87. Epub 2022 Apr 28.

Seattle, Washington USA.

Functional neurological disorder (FND) is a complex condition involving an interaction of psychological, physiological, and social factors. Despite high utilization of medical services, people with FND often suffer from poor long-term health and psychosocial outcomes, and experience stigmatization and marginalization within the medical community. Health service psychologists are well positioned to help patients with FND through the lens of the biopsychosocial model of health. Read More

View Article and Full-Text PDF

[Medically unexplained or not? Be aware of a somatic cause of Medically Unexplained Symptoms].

Ned Tijdschr Geneeskd 2022 02 24;166. Epub 2022 Feb 24.

GGZ Breburg, Tilburg.

In 2 cases of men aged 26 and 55 respectively we illustrate the complexity of MUS patients since in both cases a somatic diagnosis was missed. The first patient presented with an inability to walk and persistent pain. Because of his symptoms he lost his job, had depressive moods and used alcohol and cannabis. Read More

View Article and Full-Text PDF
February 2022

Prediction Models for Conversion From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Front Aging Neurosci 2022 7;14:840386. Epub 2022 Apr 7.

Evidence-Based Nursing, School of Nursing, Lanzhou University, Lanzhou, China.

Background And Purpose: Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no cure, and available treatments are only able to postpone the progression of the disease. Mild cognitive impairment (MCI) is considered to be a transitional stage preceding AD. Therefore, prediction models for conversion from MCI to AD are desperately required. Read More

View Article and Full-Text PDF

Formation of cubic perovskite alloy containing the ammonium cation of 2D perovskite for high performance solar cells with improved stability.

Mi-Hee Jung

RSC Adv 2021 Oct 4;11(52):32590-32603. Epub 2021 Oct 4.

Department of Nanotechnology and Advanced Materials Engineering, Sejong University 209, Neungdong-ro, Gwangjin-gu Seoul 05006 Republic of Korea +82-2-3408-4342 +82-2-6935-2597.

The perovskite solar cells have demonstrated to be strong competitors for conventional silicon solar cells due to their remarkable power conversion efficiency. However, their structural instability is the biggest obstacle to commercialization. To address these issues, we prepared (CHNH) (HC(NH)) PbI (CHNH = MA, HC(NH) = FA) perovskite alloys that contain ethylammonium (EA, CHCHNH ) and benzylammonium (BA, CHCHNH ) cations with no new additional two-dimensional (2D) perovskite phases. Read More

View Article and Full-Text PDF
October 2021

Simultaneously Accelerating Carrier Transfer and Enhancing O/CH Activation via Tailoring the Oxygen-Vacancy-Rich Surface Layer for Cocatalyst-Free Selective Photocatalytic CH Conversion.

ACS Appl Mater Interfaces 2022 May 29;14(18):21069-21078. Epub 2022 Apr 29.

MOE International Joint Laboratory of Materials Microstructure, Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China.

Solar energy-driven direct CH conversion to liquid oxygenates provides a promising avenue toward green and sustainable CH industry, yet still confronts issues of low selectivity toward single oxygenate and use of noble-metal cocatalysts. Herein, for the first time, we report a defect-engineering strategy that rationally regulates the defective layer over TiO for selective aerobic photocatalytic CH conversion to HCHO without using noble-metal cocatalysts. (Photo)electrochemical and in situ EPR/Raman spectroscopic measurements reveal that an optimized oxygen-vacancy-rich surface disorder layer with a thickness of 1. Read More

View Article and Full-Text PDF

Disorder-Order Conversion-Induced Enhancement of Thermal Stability of Pyroxene Near-Infrared Phosphors for Light-Emitting Diodes.

Angew Chem Int Ed Engl 2022 Apr 28:e202204411. Epub 2022 Apr 28.

Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.

The minimization of thermal quenching, which leads to luminescence loss at high temperatures, is one of the most important issues for near-infrared phosphors. In the present work, we investigated the properties of near-infrared Ca(Sc,Mg)(Al, Si)O  : Cr phosphors with a pyroxene-type structure under blue light excitation. The CaScAlSiO  : Cr end member of Ca(Sc,Mg)(Al,Si)O  : Cr phosphor led to broadband emission at a full-width half maximum of 215 nm, whereas the CaMgSi O  : Cr end member exhibited high thermal stability at 150 °C, with an intensity of 88. Read More

View Article and Full-Text PDF

A universal electrochemical lithiation-delithiation method to prepare low-crystalline metal oxides for high-performance hybrid supercapacitors.

RSC Adv 2021 Sep 13;11(48):30407-30414. Epub 2021 Sep 13.

School of Artificial Intelligence, Nanjing University of Information Science and Technology Nanjing 210044 China

The electrochemical performance of transition metal oxides (TMOs) for hybrid supercapacitors has been optimized through various methods in previous reports. However, most previous research was mainly focused on well-crystalline TMOs. Herein, the electrochemical lithiation-delithiation method was performed to synthesise low-crystallinity TMOs for hybrid supercapacitors. Read More

View Article and Full-Text PDF
September 2021

The tic in TikTok and (where) all systems go: Mass social media induced illness and Munchausen's by internet as explanatory models for social media associated abnormal illness behavior.

Clin Child Psychol Psychiatry 2022 Apr 27:13591045221098522. Epub 2022 Apr 27.

Department of Psychiatry, Division of Child and Adolescent Psychiatry, 12275Washington University in St Louis School of Medicine, St Louis, MO, USA.

This paper explores the recent phenomenon of adolescents presenting en masse (both online and in clinical settings) with symptoms seemingly acquired from viewing illness-related content posted by social media influencers. The most frequently reproduced illnesses have included Dissociative Identity Disorder (DID) and Tourette Syndrome. It discusses evidence that the recent spate of new-onset, severe tics are a form of Mass Psychogenic Illness facilitated by social media networks (a phenomenon labeled Mass Social Media Induced Illness). Read More

View Article and Full-Text PDF

NIR-II-Responsive [email protected] Nanotheranostics for Photoacoustic Imaging-Guided Sonodynamic-Enhanced Synergistic Phototherapy.

Langmuir 2022 May 26;38(18):5502-5514. Epub 2022 Apr 26.

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.

The therapeutic effect of photothermal therapy (PTT) and photodynamic therapy (PDT) is severely limited because of the shallow tissue penetration depth of the first near-infrared (NIR-I) light. Multifunctional nanotheranostics irradiated by the second near-infrared (NIR-II) light have received wide interest with respect to deeper tissue penetration, and sonodynamic therapy (SDT) synergistic phototherapy can achieve the complete elimination of tumors. Herein, we successfully constructed a single NIR-II light-induced nanotheranostic using cerium oxide (CeO) with abundant oxygen vacancies for photoacoustic imaging-guided SDT-enhanced phototherapy for the first time. Read More

View Article and Full-Text PDF

No Man's Land Between Psychiatry and Neurology: Functional Neurological Disorders and Conversion Disorder in Emergency Department Settings.

Psychiatr Danub 2022 ;34(1):109-110

Early Intervention Unit, Department of Psychiatry, Centro Hospitalar Psiquiátrico de Lisboa, Avenida do Brasil, Lisbon, Portugal,

View Article and Full-Text PDF
January 2022

Leukocyte Phosphomannomutase and Phosphomannose Isomerase Activity in an Indian Cohort.

Indian J Clin Biochem 2022 Apr 17;37(2):238-241. Epub 2020 Nov 17.

Department of Biochemistry, P. D. Hinduja Hospital & MRC, Veer Savarkar Marg, Mahim, Mumbai, 400016 India.

Advances in molecular sequencing technology has increased the diagnostic yield for Congenital disorder of glycosylation (CDG). However, novel variants or those of uncertain significance (vus) often pose a challenge and in such cases confirmed diagnosis can be warranted through enzyme analysis of these defects. We thus, aimed to optimize leukocyte-based enzyme assays for first two enzymes involved in N-glycosylation pathway i. Read More

View Article and Full-Text PDF

McLeod syndrome with a novel XK frameshift mutation: A case report.

Medicine (Baltimore) 2022 Mar 11;101(10):e28996. Epub 2022 Mar 11.

Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Rationale: McLeod syndrome (MLS) is a rare X-linked neurohematologic disorder caused by loss-of-function mutations in the XK gene. However, variations in the XK gene remain to be elucidated. Here, we report the clinical phenotype and genetic features of a patient with MLS caused by a novel frameshift mutation in the XK gene. Read More

View Article and Full-Text PDF

Comparative efficacy and safety of traditional Chinese patent medicine for cognitive dysfunction in diabetic cognitive dysfunction: A protocol for systematic review and Bayesian network meta-analysis.

Medicine (Baltimore) 2022 Mar 11;101(10):e28946. Epub 2022 Mar 11.

Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.

Background: More and more studies have shown that cognitive dysfunction is one of the main complications of diabetes. The disorder of glucose and lipid metabolism seriously damages brain function and accelerates the conversion to dementia. At present, there are no drugs that can directly treat diabetic cognitive dysfunction. Read More

View Article and Full-Text PDF

Delivering the Diagnosis: A Practical Approach to a Patient With a Functional Neurological Disorder.

Semin Pediatr Neurol 2022 Apr 2;41:100948. Epub 2021 Dec 2.

Department of Pediatrics, Division of Neurology, Nationwide Children's Hospital, Columbus, OH.

Functional Neurological Disorders are a common and debilitating group of diseases that have been the subject of stigma and confusion across medical history. It is well-documented that prognosis and even possible resolution of symptoms are linked to successful delivery of the diagnosis by the clinician, and correct understanding of diagnosis by the patient. In the following article, we delineate the nature of these disorders and provide an overview to assist providers successfully navigate the communication of these diagnoses to patients and families. Read More

View Article and Full-Text PDF

Sensory Processing Difficulties in Patients with Functional Neurological Disorder: Occupational Therapy Management Strategies and Two Cases.

Semin Pediatr Neurol 2022 Apr 14;41:100951. Epub 2022 Jan 14.

Department of Occupational Therapy, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Division of Cognitive Behavioral Neurology, Department of Neurology, Functional Neurological Disorder Unit, Massachusetts General Hospital, Harvard Medical School Boston, MA. Electronic address:

Functional neurological disorder (FND) is a condition at the intersection of neurology and psychiatry, with some patients experiencing sensory hypersensitivities and other sensory processing difficulties. It has been postulated that poor integration and modulation of sensory information with cognitive, affective and behavioral processes may play a role in the pathophysiology of FND. In this article, we first succinctly review the role for occupational therapy (OT) in the multidisciplinary therapeutic approach to managing patients with FND. Read More

View Article and Full-Text PDF

Diagnosis of Functional Weakness and Functional Gait Disorders in Children and Adolescents.

Semin Pediatr Neurol 2022 Apr 11;41:100955. Epub 2022 Mar 11.

Department of Neurosciences, Queensland Childrens Hospital, Brisbane, Queensland, Australia; The University of Queensland, Brisbane, Queensland, Australia. Electronic address:

Functional neurological disorder is neurological dysfunction not primarily explained by pathophysiologic or structural abnormalities and can present in children and adolescents with limb weakness, gait abnormality, non-epileptic seizures or sensory changes. In this review article we focus primarily on the diagnosis of functional limb weakness and functional gait disorders, and how to differentiate functional neurological disorders from structural or pathologic neurological presentations of weakness or gait disturbance. Detailed history and attentive observation of a patient outside of the formal neurological examination can be pertinent to identifying inconsistency and incongruency in keeping with functional neurological presentations. Read More

View Article and Full-Text PDF

Diagnosis and Initial Treatment of Functional Movement Disorders in Children.

Semin Pediatr Neurol 2022 Apr 5;41:100953. Epub 2022 Feb 5.

Department of Neurology, Division of Child Neurology, Stanford University School of Medicine, Palo Alto, CA. Electronic address:

Functional movement disorders (FMD) are complex neurobehavioral disorders that can be a significant source of disability for both children and their caregivers. While FMD in the adult population is better characterized, the aim of this paper is to review the pertinent clinical and historical features, diagnostic criteria, and multi-disciplinary management of FMD in the pediatric population. We highlight recent trends in pediatric FMD, including the increase in functional tic-like behaviors that has been observed during the COVID-19 pandemic. Read More

View Article and Full-Text PDF

Functional Neurological Disorders in Children and Adolescents - A Long-Overdue Renaissance.

Dara V F Albert

Semin Pediatr Neurol 2022 Apr 23;41:100954. Epub 2022 Feb 23.

Department of Pediatrics, Division of Neurology, Nationwide Children's Hospital/The Ohio state University, Columbus, OH. Electronic address:

View Article and Full-Text PDF

Functional Neurological Disorders in Children - A Historical Perspective.

Daniel Freedman

Semin Pediatr Neurol 2022 Apr 4;41:100950. Epub 2022 Jan 4.

Department of Neurology, Dell Medical School, Austin, TX. Electronic address:

The modern diagnosis of functional neurological disorders (FND) describes a diverse set of neurological symptoms without identifiable pathology. The history of FND and its prescientific predecessor, hysteria, is complex and deeply rooted in sexism. Key moments in this history have contributed to the advancement of understanding in functional disorders that neurologists should be aware of. Read More

View Article and Full-Text PDF

The Role of Physiotherapy in the Management of Functional Neurological Disorder in Children and Adolescents.

Semin Pediatr Neurol 2022 Apr 19;41:100947. Epub 2021 Nov 19.

Department of Psychological Medicine, The Children's Hospital at Westmead, Westmead, NSW, Australia; University of Sydney Medical School, NSW, Australia; Westmead Institute for Medical Research, Westmead, NSW, Australia. Electronic address:

Children and adolescents with functional neurological (conversion) disorder (FND) present with symptoms of impaired motor and sensory function. FND involves complex interactions between the brain, mind, body, and lived experience of the child. The gold standard for treatment is therefore a holistic, biopsychosocial approach with multimodal interventions delivered by a multidisciplinary team. Read More

View Article and Full-Text PDF

Updates in Functional Movement Disorders: from Pathophysiology to Treatment Advances.

Curr Neurol Neurosci Rep 2022 05 19;22(5):305-311. Epub 2022 Apr 19.

Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Purpose Of Review: This review discusses advances in functional movement disorders (FMD) over the past 3 years, with a focus on risk factors, diagnosis, pathophysiology, neuroimaging studies, and treatment.

Recent Findings: The past decade has brought a revived interest in functional movement disorders, with a growing number of studies exploring pathophysiological mechanisms. Here, we review recent studies demonstrating changes in attention, emotional and sensorimotor function in FMD. Read More

View Article and Full-Text PDF

Alzheimer's Disease: An Update and Insights Into Pathophysiology.

Front Aging Neurosci 2022 30;14:742408. Epub 2022 Mar 30.

Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Alzheimer's disease (AD) is an irreversible brain disorder associated with slow, progressive loss of brain functions mostly in older people. The disease processes start years before the symptoms are manifested at which point most therapies may not be as effective. In the hippocampus, the key proteins involved in the JAK2/STAT3 signaling pathway, such as p-JAK2-Tyr1007 and p-STAT3-Tyr705 were found to be elevated in various models of AD. Read More

View Article and Full-Text PDF