18,569 results match your criteria Controversies in Prostate Cancer


High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions.

Physiology (Bethesda) 2019 Jan;34(1):56-70

Department of Diabetes, Central Clinical School, Monash University , Melbourne , Australia.

It is well established that different types of exercise can provide a powerful stimulus for mitochondrial biogenesis. However, there are conflicting findings in the literature, and a consensus has not been reached regarding the efficacy of high-intensity exercise to promote mitochondrial biogenesis in humans. The purpose of this review is to examine current controversies in the field and to highlight some important methodological issues that need to be addressed to resolve existing conflicts. Read More

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January 2019

Controversies in Screening and Diagnostic Criteria for Gestational Diabetes in Early and Late Pregnancy.

Front Endocrinol (Lausanne) 2018 27;9:696. Epub 2018 Nov 27.

Division of Obstetrics and Feto-Maternal Medicine, Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.

This review serves to evaluate the screening and diagnostic strategies for gestational diabetes and overt diabetes in pregnancy. We focus on the different early screening and diagnostic approaches in first trimester including fasting plasma glucose, random plasma glucose, oral glucose tolerance test, hemoglobin A1c, risk prediction models and biomarkers. Early screening for gestational diabetes is currently not recommended since the potential benefits and harms of early detection and subsequent treatment need to be further evaluated in randomized controlled trials. Read More

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November 2018

Successful management of iatrogenic coronary arteriovenous fistula developed during chronic total occlusion intervention.

J Cardiol Cases 2012 Oct 3;6(4):e96-e99. Epub 2012 Jun 3.

Cardiovascular Center, Korea University Guro Hospital, 80, Guro-dong, Guro-gu, Seoul 152-703, Republic of Korea.

There have been some reports of iatrogenic coronary arteriovenous fistula (AVF) developing during percutaneous coronary intervention (PCI). PCI for chronic total occlusion (CTO) is more challenging due to a higher rate of procedural failure and increased risk of periprocedural complications. Recently, the coronary CTO guidewire has made rapid strides and revolutionized the procedure to increase high success rates for CTO revascularization. Read More

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October 2012

Review shows that thyroid hormone substitution could benefit transient hypothyroxinaemia of prematurity but treatment strategies need to be clarified.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Neonatology, University Hospitals Leuven, KU, Leuven, Belgium.

Aim: Thyroid hormones are crucial for fetal and neonatal brain development. This paper provides an overview of the normal role of thyroid hormones in fetal brain development and the pathophysiology of transient hypothyroxinaemia of prematurity (THOP). It also discusses the diagnostic and therapeutic controversies around THOP and looks at directions for future research. Read More

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December 2018
1 Read

Lyme neuroborreliosis- clinical outcomes, controversy, pathogenesis, and polymicrobial infections.

Ann Neurol 2018 Dec 10. Epub 2018 Dec 10.

Department of Molecular Genetics and Microbiology and Pathology, Stony Brook University School of Medicine, Stony Brook, NY, USA.

Lyme Borreliosis is the object of numerous misconceptions. In this review, we revisit the fundamental manifestations of neuroborreliosis (meningitis and cranial and radiculoneuritis) as these have withstood the test of time. We also discuss other manifestations that are less frequent. Read More

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December 2018

Iron in the Tumor Microenvironment-Connecting the Dots.

Front Oncol 2018 26;8:549. Epub 2018 Nov 26.

Department of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of Innsbruck, Innsbruck, Austria.

Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute to mutagenicity and malignant transformation. Once transformed, malignant cells require high amounts of iron for proliferation. Read More

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November 2018
1 Read

New developments and controversies in cervical cancer.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):481-483. Epub 2018 Oct 5.

Electroradiology Dept, University of Medical Sciences, Poznan, Poland.

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October 2018

Metabolic Syndrome and Cardiovascular Disease: A Health Challenge in Mexico.

Arch Med Res 2018 Oct 24. Epub 2018 Oct 24.

Western Diabetes Institute, Western University of Health Sciences, Pomona, California, USA.

Metabolic Syndrome (MetS) is a cluster of risk factors that, taken alone or synergically, are independent predictors of type 2 diabetes and cardiovascular disease (CVD), which are both major public health problems that requires urgent containment actions. Current controversies regarding MetS are focused on ascertain the unifying explanation of molecular and pathophysiological mechanisms originating the syndrome, involving insulin resistance and low-grade chronic inflammation. This review aims to present the clinical relevance of MetS and its complications, as well as the hypotheses addressing its etiopathogenic relation with CVD. Read More

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October 2018

Can sentinel node biopsy be safely omitted in thin melanoma? Risk factor analysis of 1272 multicenter prospective cases.

Eur J Surg Oncol 2018 Dec 1. Epub 2018 Dec 1.

Veneto Institute of Oncology IOV-IRCCS, Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Via Gattamelata, 64, 35128, Padova, Italy.

Background: The indication to sentinel node biopsy (SNB) for thin melanomas (Breslow <1 mm) is still subject to controversies. The aim of this paper is to review all SNB performed for thin melanoma and to analyze factors related to lymphatic metastasis. Moreover, the diagnostic performance of the 5th, 6th, 7th and 8th AJCC classifications for cutaneous melanoma were investigated. Read More

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December 2018

Sirtuin signaling in cellular senescence and aging.

BMB Rep 2018 Dec 11. Epub 2018 Dec 11.

Department of Biological Sciences, Inha University, Incheon 22212, Korea.

Sirtuin is an essential factor that delays cellular senescence and extends the organismal lifespan through the regulation of diverse cellular processes. Suppression of cellular senescence by Sirtuin is mainly mediated through delaying the age-related telomere attrition, sustaining genome integrity and promotion of DNA damage repair. In addition, Sirtuin modulates the organismal lifespan by interacting with several lifespan regulating signaling pathways including insulin/IGF-1 signaling pathway, AMP-activated protein kinase, and forkhead box O. Read More

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December 2018

Basal position of two new complete mitochondrial genomes of parasitic Cymothoida (Crustacea: Isopoda) challenges the monophyly of the suborder and phylogeny of the entire order.

Parasit Vectors 2018 Dec 10;11(1):628. Epub 2018 Dec 10.

Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, and State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, People's Republic of China.

Background: Isopoda is a highly diverse order of crustaceans with more than 10,300 species, many of which are parasitic. Taxonomy and phylogeny within the order, especially those of the suborder Cymothoida Wägele, 1989, are still debated. Mitochondrial (mt) genomes are a useful tool for phylogenetic studies, but their availability for isopods is very limited. Read More

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December 2018

Arterial stiffness and subclinical aortic damage of reclassified subjects as stage 1 hypertension according to the new 2017 ACC/AHA blood pressure guidelines.

Vasa 2018 Dec 10:1-8. Epub 2018 Dec 10.

1 First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background: The 2017 ACC/AHA blood pressure (BP) guidelines generated controversies due to the new proposed BP cut-off values defining hypertension. We aimed to assess aortic stiffness of subjects who are reclassified as stage 1 hypertensive according to the new guidelines and compare them with the subjects of "elevated BP" category.

Patients And Methods: Data from the "Corinthia" study, an observational, cross-sectional survey of 2,043 participants were analyzed. Read More

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December 2018

Perineural invasion in oral cancer: challenges, controversies and clinical impact.

Chin Clin Oncol 2018 Dec 4. Epub 2018 Dec 4.

Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center and National Institute of Science and Technology on Oncogenomics (INCITO), Brazil.

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December 2018

[Calcaneal fractures: controversies and consensus].

Acta Ortop Mex 2018 May-Jun;32(3):172-181

Universidad de La Laguna. Tenerife. España.

Calcaneal fractures are the most common tarsal fractures and their treatment is still debated today. We intend in this update to highlight the points of controversy and clarify the consensus, especially in the treatment of intra-articular fractures, as well as to describe the management of major complications. Read More

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December 2018
2 Reads

The promises and risks of probiotic Bacillus species.

Acta Biochim Pol 2018 Dec 6. Epub 2018 Dec 6.

Uniwersytet Gdański Wydział Chemii Katedra Biotechnologii Molekularnej ul. Wita Stwosza 63 80-308 Gdańsk.

Supplementing the human microbiome with probiotic microorganisms is a proposed solution for civilization syndromes such as dysbiosis and gastrointestinal tract (GIT) disorders. Bimodal probiotic strains of the Bacillus genus constitute the microbiota of the human environment, and are typically found in soil, water, a number of non-dairy fermented foods, as well as in human and animal GIT. Probiotic Bacillus sp. Read More

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December 2018

Controversies and emerging topics in lung transplantation.

Breathe (Sheff) 2018 Dec;14(4):278-287

The Lung Transplant Unit, St Vincent's Hospital, Sydney, Australia.

Lung transplantation provides a realistic hope of improved survival and enhanced quality of life. However, outcomes can be disappointing, meaning many decisions are highly controversial. Practice is largely based on expert opinion and there is a dearth of high-level evidence. Read More

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December 2018
2 Reads

Polycystosis of the renal sinus or polycystic kidney disease Controversies, challenges and history of a shared discovery.

Actas Urol Esp 2018 Dec 6;42(10):645-648. Epub 2018 Jul 6.

Servicio de Urología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, España.

Objective: To recall the history of the discovery of non-nephron cystic disease, detected simultaneously in 2 hospitals in Madrid, and the vicissitudes that the authors endured during the process of recognising this disease, while being ignored by the international scientific literature.

Material And Method: We analysed the authors' first publications and presentations, their correspondence relaying the difficulties in reporting the confusion with adult polycystic kidney disease (APKD) and the subsequent nosological identification of the process. We consulted with individuals who worked with the 2 authors to increase the accuracy and objectivity of the history report. Read More

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December 2018

Deep learning-Using machine learning to study biological vision.

J Vis 2018 Dec;18(13)

Department of Psychology and Center for Neural Science, New York University, New York, NY, USA.

Many vision science studies employ machine learning, especially the version called "deep learning." Neuroscientists use machine learning to decode neural responses. Perception scientists try to understand how living organisms recognize objects. Read More

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December 2018
1 Read

Abdominal radiographs in the emergency department: current status and controversies.

J Med Radiat Sci 2018 Dec;65(4):250-251

Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore, Singapore.

This editorial is discussing about the indiscriminate use of abdominal radiographs in the emergency department in general, with focus on value of the erect abdominal radiograph for the diagnosis of mechanical bowel obstruction and paralytic ileus. Read More

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December 2018
1 Read

Consensus and controversies regarding follow-up after curative intent treatment of non-metastatic colorectal cancer: a synopsis of guidelines used in countries represented in ESCP.

Colorectal Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgery, Aarhus University Hospital, Aarhus, Denmark.

Aim: It is common clinical practice to follow patients for a period of years after curative intent treatment of non-metastatic colorectal cancer, but follow-up strategies vary widely. The aim of this systematic review was to provide an overview of recommendations in guidelines from ESCP member countries on this topic, with supporting evidence.

Methods: A systematic search of Medline, Embase and guidelines databases Tripdatabase, BMJ Best Practice and Guidelines International Network was performed. Read More

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November 2018
2 Reads

Surgical management of intrathoracic goitres.

Eur Arch Otorhinolaryngol 2018 Nov 30. Epub 2018 Nov 30.

Otorhinolaryngology Head and Neck Surgery, University of Udine School of Medicine, Udine, Italy.

Background: Intrathoracic goitres (ITG) often present with compressive symptoms and require specialised care by experienced surgical teams. Most ITG can be accessed by a transcervical approach (TCA) and only between 1 and 15% will require an extracervical approach (ECA). Many controversies exist regarding the clinical presentation, evaluation, selection of cases for ECA, surgical technique and outcomes. Read More

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November 2018
2 Reads

Current controversies and future directions in the diagnosis and management of differentiated thyroid cancers.

Gland Surg 2018 Oct;7(5):473-486

Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.

Despite the development of novel diagnostic, surgical, and chemotherapeutic approaches to differentiated thyroid cancers (DTCs), the diagnosis and management of these tumors remains controversial. The most recent American Thyroid Association (ATA) guidelines, released in 2015, reflect a recent shift towards less aggressive management for patients with DTCs. However, many clinicians have expressed concern that more conservative management will put patients at risk for disease recurrence and metastasis. Read More

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October 2018
1 Read

Optimal management of postoperative parenchymal air leaks.

J Thorac Dis 2018 Nov;10(Suppl 32):S3789-S3798

Division of Thoracic Surgery, Department of Surgery, Queen Elizabeth II Hospital - Victoria Campus, Dalhousie University, Halifax, NS, Canada.

Air leaks are the most common complication after pulmonary resection. Enhanced recovery after surgery (ERAS) programs must be designed to manage parenchymal air leaks. ERAS programs should consider two components when creating protocols for air leaks: assessment and management. Read More

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November 2018
1 Read

Surgery for parasitic lung infestations: roles in diagnosis and treatment.

J Thorac Dis 2018 Oct;10(Suppl 28):S3446-S3457

Manmohan Cardiothoracic Vascular and Transplant Centre, Kathmandu, Nepal.

Pulmonary parasitic infestations are a worldwide problem associated with significant morbidity and socioeconomic impact. They are known to have varied clinical presentations and radiological appearances. Prevention of parasite transmission and medical treatment of cases form the two pillars of control of these diseases. Read More

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October 2018
1 Read

Endoscopic surgery of spontaneous basal ganglionic hemorrhage.

Neurol India 2018 Nov-Dec;66(6):1694-1703

Department of Neurosurgery, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India.

Introduction: Although there are controversies about the optimal management of spontaneous intracerebral hemorrhage (ICH), benefits of endoscopic procedures in ICH have been reported. This study is aimed to evaluate the result of 270 patients undergoing endoscopic treatment of ICH.

Methods: This was a retrospective study from July 2008 to June 2017. Read More

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December 2018
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Diagnosis of childhood growth hormone deficiency: Controversies, consensus and the need for new diagnostic tools.

Neurol India 2018 Nov-Dec;66(6):1685-1686

Department of Endocrinology, All India Institute of Medical Scienecs, New Delhi, India.

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December 2018

Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.

Authors:
Amy Klion

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):326-331

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Hypereosinophilic syndromes (HESs) are a heterogeneous group of rare disorders characterized by peripheral eosinophilia and eosinophilic end organ complications. Conventional therapies, including glucocorticoids and cytotoxic and immunomodulatory agents, have variable efficacy and significant toxicity. Although the recent development of agents that target eosinophils, including tyrosine kinase inhibitors and monoclonal antibodies, provides the possibility of more effective, less toxic approaches to treatment of HES, there are little available data to guide their use in these conditions. Read More

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November 2018
1 Read

Clarity and controversy around rate control in AF, the orphan child in AF therapeutics.

Int J Cardiol 2018 Nov 15. Epub 2018 Nov 15.

Research Center, Montreal Heart Institute and Université de Montréal, Canada; Department of Pharmacology and Therapeutics, McGill University, Canada; Institute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-, Essen, Germany; LIRYC Institute, Bordeaux, France. Electronic address:

The vast majority of clinical arrhythmia-management research over the past couple of decades has focused on catheter-based therapeutic advances. There has been much less emphasis on rate-control strategies; however, the majority of patients with atrial fibrillation (AF) will require some form of rate-control management, making AF rate-control the single most widely used therapeutic component in AF-patients. While the general principles governing AF rate-control have remained largely unchanged, they are often underappreciated. Read More

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November 2018

Controversies in Allergy: Food Testing and Dietary Avoidance in Atopic Dermatitis.

J Allergy Clin Immunol Pract 2018 Nov 27. Epub 2018 Nov 27.

Division of Allergy, Immunology and Rheumatology, University of Wisconsin-Madison, Madison, Wis. Electronic address:

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November 2018
1 Read

Notch dysregulation and HS: let's talk about Numb.

Br J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Via Pansini 5, Napoli, Italy.

We read with great interest the article by J. W. Frew regarding Notch Dysregulation as an Epiphenomenon in Inflammatory Skin Diseases. Read More

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December 2018
3 Reads

Evaluating the associations between urinary excretion of magnesium and that of other components in calcium stone-forming patients.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, No. 103, 9th Boostan Street, Pasdaran Avenue, Tehran, Iran.

Purpose: Magnesium plays numerous vital roles in human's body. It is known as a protective factor in stone formation by binding to oxalate in the intestinal and urinary system, and decreasing its absorption and crystallization, respectively. Due to controversies about the association between the 24-h urine magnesium and other urine metabolites in different studies, this study was designed to find a clear answer to this question. Read More

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December 2018
1 Read

Transitions of the Understanding and Definition of Primary Glaucoma.

Chin Med J (Engl) 2018 Dec;131(23):2852-2859

Department of Glaucoma, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, China.

Objective: In previous decades, glaucoma has been primarily attributed to elevated intraocular pressure (IOP), but this has gradually been replaced by the development of optic neuropathy as the central concept of glaucoma in developed countries. However, there still remain strong controversies in the definition of glaucoma in China. In this current review, we are going to discuss these controversies and elaborate on the historical transitions of the definition of glaucoma both in China and developed countries. Read More

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December 2018
3 Reads

Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis.

Onco Targets Ther 2018 8;11:7895-7908. Epub 2018 Nov 8.

Department of Pharmacy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China,

Background: Melatonin (MLT), a kind of neuroendocrine active substance, has been reported to function in the treatment of tumors. However, there remain controversies about the curative effect of MLT in tumors in clinical studies. This study investigates the efficacy of MLT on tumor therapeutic strategies by meta-analysis. Read More

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November 2018
1 Read

Naturalizing pollution: a critical social science view on the link between potash mining and salinization in the Llobregat river basin, northeast Spain.

Philos Trans R Soc Lond B Biol Sci 2018 Dec 3;374(1764). Epub 2018 Dec 3.

Departament de Geografia, Universitat Autònoma de Barcelona, Bellaterra, Catalunya, Spain.

The scientific literature distinguishes between primary or natural and secondary or human-induced salinization. Assessing this distinction is of vital importance to assign liabilities and responsibilities in pollution cases and for designing the best policy and management actions. In this context, actors interested in downplaying the role of certain drivers of human-induced salinization can attempt to neglect its importance by referring to natural salinization, in a similar fashion to other pollution and health-related cases, from tobacco smoke to climate change. Read More

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December 2018

Challenges and controversies in perinatal physiology.

J Physiol 2018 Dec;596(23):5485-5489

Fetal Physiology and Neuroscience Group, Department of Physiology, University of Auckland, Auckland, New Zealand.

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December 2018

[The experts consensus on the surgical treatment and perioperative management of cervical spondylosis (2018)].

Authors:

Zhonghua Wai Ke Za Zhi 2018 Dec;56(12):881-884

In order to standardize the surgical care and perioperative management for patients with cervical spondylosis, the Editorial Board of has organized the several meetings with certain experienced spine surgeons regarding prevent complications related to surgical procedure, ensure the treatment safety as well as in improving the outcome efficacy. In the meantime, the relevant focused issues and repeated consulting have been reviewed and presented on a larger spectrum. By 2 years efforts, the consensus has been developed for patients with different types of cervical spondylosis. Read More

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December 2018

An update on the latest chemical therapies for reflux esophagitis in children.

Expert Opin Pharmacother 2018 Nov 29:1-9. Epub 2018 Nov 29.

e Gastroenterology department , McGill University Health Centre , Montréal , Québec , Canada.

Introduction: Gastroesophageal reflux (GER), and its complicated form gastroesophageal reflux disease (GERD) is a common condition in infants and children. As GERD is often considered to cause extra-oesophageal symptoms in children and in the absence of standardized diagnostic and treatment algorithm, many children are inappropriately exposed to empirical anti-reflux treatments, with Acid-Suppressive Medications (ASM); mostly proton pump inhibitors (PPIs). Areas covered: The authors summarize the pharmacological management of pediatric GERD and discuss the efficacy of PPIs as randomized controlled trials have failed to demonstrate their clinical efficacy in the pediatric population. Read More

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November 2018
3 Reads

Clinicopathological features and prognosis of 276 cases of primary small (≤ 2 cm) gastric gastrointestinal stromal tumors: a multicenter data review.

Surg Endosc 2018 Nov 27. Epub 2018 Nov 27.

Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.

Background: Till present, there are still controversies over the epidemiology, pathological features, types of surgical treatment, and prognoses of primary small gastric GISTs (gGISTs).

Methods: From January 1998 to January 2015, patients with primary small gGIST admitted from four high-volume medical centers of the Southern China were enrolled and their data were analyzed to evaluate their clinicopathological features, treatment and prognostic factors to provide evidence-based medical experience for clinical practice.

Results: A total of 276 primary small gGIST cases over a period of 18 years were investigated and had a median age of 60 years (range 27-91 years old). Read More

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November 2018

The Failure to Measure Dietary Intake Engendered a Fictional Discourse on Diet-Disease Relations.

Front Nutr 2018 13;5:105. Epub 2018 Nov 13.

Center for Human Nutrition at the University of Colorado, Aurora, CO, United States.

Controversies regarding the putative health effects of dietary sugar, salt, fat, and cholesterol are not driven by legitimate differences in scientific inference from valid evidence, but by a fictional discourse on diet-disease relations driven by decades of deeply flawed and demonstrably misleading epidemiologic research. Over the past 60 years, epidemiologists published tens of thousands of reports asserting that dietary intake was a major contributing factor to chronic non-communicable diseases despite the fact that epidemiologic methods do not measure dietary intake. In lieu of measuring actual dietary intake, epidemiologists collected millions of unverified verbal and textual reports of . Read More

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November 2018
5 Reads

Genome-Wide Evolutionary Analysis of Natural History and Adaptation in the World's Tigers.

Curr Biol 2018 Dec 25;28(23):3840-3849.e6. Epub 2018 Oct 25.

The State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, 100871 Beijing, China. Electronic address:

No other species attracts more international resources, public attention, and protracted controversies over its intraspecific taxonomy than the tiger (Panthera tigris) [1, 2]. Today, fewer than 4,000 free-ranging tigers survive, covering only 7% of their historical range, and debates persist over whether they comprise six, five, or two subspecies [3-6]. The lack of consensus over the number of tiger subspecies has partially hindered the global effort to recover the species from the brink of extinction, as both captive breeding and landscape intervention of wild populations increasingly require an explicit delineation of the conservation management units [7]. Read More

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December 2018
1 Read

Factors Affecting Prognosis of Patients With Osteoblastoma of the Mobile Spine: A Long-Term Follow-up Study of 70 Patients in a Single Center.

Neurosurgery 2018 Nov 27. Epub 2018 Nov 27.

Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background: Osteoblastoma (OBL) in the mobile spine is a benign tumor with aggressive potential. There is not much published information on OBL of the mobile spine as a result of rarity of the disease. There are controversies over the aggressive subtype and prognostic factors of the condition. Read More

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November 2018
1 Read

Informed Consent in Obligatory Vaccinations?

Med Sci Monit 2018 Nov 25;24:8506-8509. Epub 2018 Nov 25.

Department of Ethics and Human Philosophy, Medical University of Lublin, Lublin, Poland.

Vaccinations cause controversies for numerous reasons: medical, religious, and even personal. The following paper focuses on one more, underestimated conflict between individual autonomy and public health in regard to obligatory childhood vaccinations. Every medical intervention should be preceded by informed consent; however, informed consent in the case of obligatory vaccinations cannot be voluntary and valid. Read More

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November 2018
2 Reads

Challenges and advances in atomistic simulations of potassium and sodium Ion channel gating and permeation.

J Physiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA, U.S.A.

Ion channels are implicated in many essential physiological events such as electrical signal propagation and cellular communication. The advent of K and Na ion channel structure determination has facilitated numerous investigations of molecular determinants of their behavior. At the same time, rapid development of computer hardware and molecular simulation methodologies has made computational studies of large biological molecules in all-atom representation tractable. Read More

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November 2018
12 Reads

Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor β.

Int J Mol Sci 2018 Nov 20;19(11). Epub 2018 Nov 20.

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Box 582, SE-751 23 Uppsala, Sweden.

Metastasis of tumor cells from primary sites of malignancy to neighboring stromal tissue or distant localities entails in several instances, but not in every case, the epithelial-mesenchymal transition (EMT). EMT weakens the strong adhesion forces between differentiated epithelial cells so that carcinoma cells can achieve solitary or collective motility, which makes the EMT an intuitive mechanism for the initiation of tumor metastasis. EMT initiates after primary oncogenic events lead to secondary secretion of cytokines. Read More

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November 2018
1 Read

Effects of sky conditions on net ecosystem productivity of a subtropical coniferous plantation vary from half-hourly to daily timescales.

Sci Total Environ 2019 Feb 15;651(Pt 2):3002-3014. Epub 2018 Oct 15.

Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100190, China.

The dynamic changes of solar radiation have received wide attention in global change studies, but there are controversies about the influence of diffuse radiation on ecosystem carbon sequestration. Using eddy covariance measurements from 2010 to 2012, the effects of sky conditions extracted from adjacent sunny, cloudy, and overcast days on net ecosystem productivity (NEP) of a subtropical coniferous plantation were examined from half-hourly to daily scales. Half-hourly NEP responded to the changing radiation more efficiently on overcast days compared to sunny days, but such response did not differ obviously between cloudy and sunny days. Read More

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February 2019
5 Reads

Effects of antenatal azithromycin for Ureaplasma spp. on neonatal outcomes.

Pediatr Int 2018 Nov 20. Epub 2018 Nov 20.

Department of Pediatrics, Hallym University Medical Center, Seoul, Korea.

Background: Ureaplasma spp. in the maternal genitourinary tract has come to the attention for is becoming more evident as a cause of preterm labor, spontaneous abortion, chorioamnionitis and adverse outcomes. However, a few controversies still remain, namely, whether it should be treated aggressively or not. Read More

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November 2018
7 Reads

Faecal immunochemical tests for haemoglobin (FIT) in the assessment of patients with lower abdominal symptoms: current controversies.

Authors:
Callum G Fraser

Gastroenterol Hepatol 2018 Nov 17. Epub 2018 Nov 17.

Centre for Research into Cancer Prevention and Screening, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK. Electronic address:

Faecal immunochemical tests for haemoglobin (FIT), as an adjunct to clinical information, assist in the triage of patients presenting in primary care with lower abdominal symptoms. Controversy remains regarding whether and which qualitative and quantitative FIT can be used, which groups of patients would benefit most from FIT, whether FIT should be done in primary and/or secondary care, and how FIT should be incorporated into diagnostic pathways. Controversy also exists as to the optimum cut-off used for referral for colonoscopy. Read More

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November 2018
4 Reads

The Controversies, Challenges and Complexities of Lyme Disease: A Narrative Review.

J Pharm Pharm Sci 2018 ;21(1):429-436

Public Health Institute, Liverpool John Moore's University, Liverpool L32ET, United Kingdom.

Purpose: Lyme disease has become an increasingly important global public health concern.

Method: A narrative review was conducted and designed to present a broad perspective on Lyme disease, and describe its history and development in terms of clinical care and public health implications. A structured literature search was conducted based on the question; what is currently known about Lyme disease?

Results: The narrative review is presented in chronological order in terms of a summary of the history of Lyme disease, the complexities of clinical diagnosis, the problematic interpretation of serologic testing, the conflicting guidelines for diagnosis, treatment and management of chronic Lyme, and benefits of antibiotic treatment. Read More

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January 2018
1 Read

Mirror twin grain boundaries in molybdenum dichalcogenides.

Authors:
Matthias Batzill

J Phys Condens Matter 2018 Dec;30(49):493001

Department of Physics, University of South Florida, Tampa, FL 33620, United States of America.

Mirror twin grain boundaries (MTBs) exist at the interface between two grains of 60° rotated hexagonal transition metal dichalcogenides (TMDC). These grain boundaries form a regular atomic structure that extends in one dimension and thus may be described as a one-dimensional (1D) lattice embedded in the 2D TMDC. In this review, the different atomic structures and compositions of these MTBs are discussed. Read More

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December 2018

Perception of biological motions is preserved in people with autism spectrum disorder: electrophysiological and behavioural evidences.

J Intellect Disabil Res 2018 Nov 19. Epub 2018 Nov 19.

Department of Biomedical Sciences, Islamic Azad University of Mashhad, Mashhad, Iran.

Background: There have been some controversies over the ability of individuals with autism spectrum disorder (ASD) to perceive biological motion. In this study, we used electroencephalography and behavioural measures (recognition test) to examine whether or not children with ASD can correctly identify biological motion.

Method: Twenty participants with ASD (mean = 11. Read More

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November 2018
3 Reads