108,758 results match your criteria Contributions to nephrology[Journal]
J Phys Condens Matter 2018 Dec 17. Epub 2018 Dec 17.
Institute of Physics, Martin-Luther-Universitat Halle-Wittenberg, Halle, Sachsen-Anhalt, GERMANY.
We consider an extrinsic contribution to the anomalous and spin Hall effect in dilute alloys based on Fe, Co, Ni, and Pt hosts with different substitutional impurities. It is shown that a strong skew-scattering mechanism is absent in such crystals with multi-sheeted Fermi surfaces. Based on this finding, we conclude on the mutual exclusion of strong intrinsic and skew-scattering contributions to the considered transport phenomena. Read More
Water Res 2018 Dec 6;150:418-430. Epub 2018 Dec 6.
College of Environmental & Resource Sciences, Zhejiang University, Hangzhou, 310058, China; Ministry of Education Key Laboratory of Environment Remediation and Ecological Health, Zhejiang University, Hangzhou, 310058, China. Electronic address:
Accurate source identification is critical for optimizing water pollution control strategies. Although the dual stable isotope (N-NO/O-NO) approach has been widely applied for differentiating riverine nitrogen (N) sources, the relatively short-term (<1 yr) N-NO/O-NO records typically used in previous studies often hinders rigorous assessment due to high temporal variability associated with watershed N dynamics. Estimated contributions of legacy N sources in soils and groundwater to riverine N export by modeling approaches in many previous studies also lack validation from complementary information, such as multiple stable isotopes. Read More
Environ Pollut 2018 Dec 7;246:303-310. Epub 2018 Dec 7.
National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 491 Anagawa, Inage, Chiba, 263-8555, Japan.
The marine environment is complex, and it is desirable to have measurements for seawater samples collected at the early stage after the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident to determine the impact of Fukushima-derived radionuclides on this environment. Here Pu isotopes in seawater collected 33-163 km from the FDNPP site at the very early stage after the accident were determined (May 2011, within two months after the accident). The distribution and temporal variation of Pu and Pu were studied. Read More
Environ Pollut 2018 Dec 7;246:274-283. Epub 2018 Dec 7.
Department of Civil & Environmental Engineering, University of Wisconsin-Madison, Madison, 53705, USA; Environmental Chemistry and Technology, University of Wisconsin-Madison, Madison, 53706, USA. Electronic address:
Two hundred sixty-three fine particulate matter (PM) samples were collected over fourteen months in Fresno and Bakersfield, California. Samples were analyzed for organic carbon (OC), elemental carbon (EC), water soluble organic carbon (WSOC), and 160 organic molecular markers. Chemical Mass Balance (CMB) and Positive Matrix Factorization (PMF) source apportionment models were applied to the results in order to understand monthly and seasonal source contributions to PM OC. Read More
Environ Pollut 2018 Dec 4;246:225-236. Epub 2018 Dec 4.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Center for Excellence in Regional Atmospheric Environment, Chinese Academy of Sciences, Xiamen, 361021, China. Electronic address:
In the study, personal PM exposures and their source contributions were characterized for 159 subjects living in the Beijing Metropolitan area. The exposures and sources were examined as functions of residential location, season, vocation, cigarette smoking, and time spent outdoors. Sampling was performed for two categories of volunteers, guards and students, that lived in urban and suburban areas of Beijing. Read More
J Am Coll Health 2018 Dec 17:1-7. Epub 2018 Dec 17.
a Department of Psychology , University of Memphis , Memphis , TN , USA.
Objective: Approximately one-third of college students are categorized as overweight/obese and elevated weight has been associated with increased risk of depressive symptoms. Less is known about protective factors in this context. This study examined associations between depressive symptoms and health behaviors, as well as body image variables among college students with overweight/obesity, while accounting for contributions of BMI and demographics. Read More
Environ Sci Technol 2018 Dec 17. Epub 2018 Dec 17.
Detailed multiphase chemistry box model studies are carried out, investigating halogen radical activation at polluted coastal areas. Simulations are performed for a non-permanent cloud and a cloud-free scenario and reveal that ClNO photolysis as well as ICl photolysis is crucial for gas-phase Cl atom activation. In the cloud scenario, the integrated ClNO and ICl photolysis rates are 3. Read More
J Clin Child Adolesc Psychol 2018 Dec 17:1-13. Epub 2018 Dec 17.
a Department of Psychology and Human Development , Vanderbilt University.
Children require adult caregivers to survive and thrive. In the absence of committed and nurturing care, children face increased risk for a number of difficulties, including internalizing and externalizing psychopathology, cognitive and language deficits, and social difficulties. Recent changes in the U. Read More
Endocr Metab Immune Disord Drug Targets 2018 Dec 17. Epub 2018 Dec 17.
Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa - PB. Brazil.
In silico studies are increasingly being applied by researchers due to reductions in time and costs for new prototype synthesis; obtaining substances that present better therapeutic profiles. In the present work, in addition to discussing multi-target drug discovery and the contributions of in silico studies to rational bioactive planning against metabolic disorders such as diabetes and obesity, we review various in silico study contributions to the fight against human metabolic pathologies. Read More
Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.
FIOCRUZ, Rio de Janeiro. Brazil.
Vitamin A and its derivatives (retinoids) act as potent regulators in many aspects of mammalian reproduction, development, repair, and maintenance of differentiated tissue functioning. Unlike other vitamins, Vitamin A and retinoids, which have hormonal actions, present significant toxicity, which plays roles in clinically relevant situations, such as hypervitaminosis A and retinoic acid ("differentiation") syndrome. Although clinical presentation is conspicuous in states of insufficient or excessive Vitamin A and retinoid concentration, equally relevant effects on host resistance to specific infectious agents, and in the general maintenance of immune homeostasis, may go unnoticed, because their expression requires either pathogen exposure or the presence of inflammatory co-morbidities. Read More
Teach Learn Med 2018 Dec 15:1-10. Epub 2018 Dec 15.
c Department of Medicine , Uniformed Services University , Bethesda , Maryland , USA.
Phenomenon: With scholarly collaborations come questions about the order of authorship. Authorship order is an important consideration because it often used as an indicator of seniority, expertise, leadership, and scholarly productivity. As a result, authorship order factors into decisions about hiring, salary, resource allocation, and professional advancement. Read More
Small 2018 Dec 17:e1803895. Epub 2018 Dec 17.
Department of Materials Science and Engineering, National University of Singapore, 117574, Singapore, Singapore.
Supercapacitors (SCs) have been widely studied as a class of promising energy-storage systems for powering next-generation E-vehicles and wearable electronics. Fabricating hybrid-types of electrode materials and designing smart nanoarchitectures are effective approaches to developing high-performance SCs. Herein, first, a Ni-Co selenide material (Ni,Co)Se with special cactus-like structure as the core, to scaffold the NiCo-layered double hydroxides (LDHs) shell, is designed and fabricated. Read More
Psychophysiology 2019 Jan 22;56(1):e13306. Epub 2018 Nov 22.
Department of Psychology, The Ohio State University, Columbus, Ohio.
Understanding psychosomatic relations, and their implications for heath, is importantly dependent on our conceptual and measurement models. The historical view of reciprocal control of the autonomic branches is applicable in some contexts, but not others. Control of the autonomic branches can vary reciprocally, independently, and even coactively. Read More
Drugs Aging 2018 Dec 17. Epub 2018 Dec 17.
Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallett St, Camperdown, NSW, 2050, Australia.
The concept of personalised medicine in Parkinson's disease has arrived where the implications of findings made in research are certain to have an increasing impact upon clinical practice. Disease heterogeneity in Parkinson's disease has been well described and lends itself to the construct of personalised medicine where it is hypothesised that a greater understanding of genetic and pathophysiological contributions may underpin the sub-groups described. This in turn has driven the development of potentially individualised disease-modifying therapies where, for example, we are beginning to see treatments that target patients with Parkinson's disease with specific genetic mutations. Read More
ACS Omega 2018 Nov 21;3(11):15837-15849. Epub 2018 Nov 21.
State Key Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, Beijing University of Chemical Technology, P.O. Box 53, 15 BeiSanHuan East Road, Beijing 100029, P. R. China.
HIV-1 protease plays an important role in the processing of virus infection. Protease is an effective therapeutic target for the treatment of HIV-1. Our data set is based on a selection of 4855 HIV-1 protease inhibitors (PIs) from ChEMBL. Read More
ACS Omega 2018 Nov 2;3(11):14704-14716. Epub 2018 Nov 2.
Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.
Machine learning methods have revolutionized modern science, providing fast and accurate solutions to multiple problems. However, they are commonly treated as "black boxes". Therefore, in important scientific fields such as medicinal chemistry and drug discovery, machine learning methods are restricted almost exclusively to the task of performing predictions of large and heterogeneous data sets of chemicals. Read More
Front Psychol 2018 29;9:2263. Epub 2018 Nov 29.
Department of Educational Psychology and Counseling, National Taiwan Normal University, Taipei, Taiwan.
Scientific illustrations play an important role in scientific texts, however, young readers show limited ability to use illustration information and integrate it with the text in multimedia learning. The primary goal of the present study was to investigate if strategy instructions for illustrated text reading focused on scientific illustration reading and text-illustration integration can help young readers overcome their deficiencies and change their reading processes, learning outcomes, and subjective perceptions of article difficulty and enjoyment, illustration enjoyment, and self-evaluation of learning. Besides, is subjective perception of the article related to reading behavior? Sixty-two fourth-grade students read an illustrated science text while their eye movements were recorded, and then completed a reading test and questionnaire. Read More
Front Psychiatry 2018 29;9:634. Epub 2018 Nov 29.
Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.
Extending beyond the motor domain, the cerebellum is involved in various aspects of cognition and affect. Multidisciplinary evidence has demonstrated topographic organization of higher-order cognitive functions within the cerebellum. We here review recent neuroimaging research that indicates cerebellar contributions to major depressive disorder (MDD). Read More
Front Integr Neurosci 2018 29;12:59. Epub 2018 Nov 29.
Department of General Psychology, Justus-Liebig University Giessen, Giessen, Germany.
Active finger movements play a crucial role in natural haptic perception. For the perception of different haptic properties people use different well-chosen movement schemes (Lederman and Klatzky, 1987). The haptic property of softness is stereotypically judged by repeatedly pressing one's finger against an objects' surface, actively indenting the object. Read More
Ecol Monogr 2018 Nov 11;88(4):560-584. Epub 2018 Jul 11.
Institute for Biodiversity and Ecosystem Dynamics University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands.
This paper presents a comprehensive theory for the demographic analysis of populations in which individuals are classified by both age and stage. The earliest demographic models were age classified. Ecologists adopted methods developed by human demographers and used life tables to quantify survivorship and fertility of cohorts and the growth rates and structures of populations. Read More
Mol Cell 2018 Dec 1. Epub 2018 Dec 1.
Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address:
Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following treatment with the pan-BET BRD inhibitor JQ1, revealing broad rewiring of the interaction landscape, with three distinct classes of behavior for the 603 unique interactors identified. A group of proteins associate in a JQ1-sensitive manner with BET BRDs through canonical and new binding modes, while two classes of extra-terminal (ET)-domain binding motifs mediate acetylation-independent interactions. Read More
Clin Dermatol 2019 Jan - Feb;37(1):60-70. Epub 2018 Sep 17.
Department of Dermatology and Cutaneous Biology and the Jefferson Center for International Dermatology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:
The history of dermatology is a significant aspect of the specialty, if only to put into perspective the development of the specialty. Early pioneers recorded the progress made in the specialty, as it became a separate discipline in the latter part of the 19th century. Periodically, dermatologic societies and meetings have shown interest by including sessions and exhibits on the specialty. Read More
Am J Respir Crit Care Med 2018 Dec 15. Epub 2018 Dec 15.
Northwestern University, Rheumatology/Medicine, Chicago, Illinois, United States.
Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are important for disease pathogenesis.
Objectives: To determine whether single-cell RNA sequencing can reveal disease-related heterogeneity within alveolar macrophages, epithelial cells or other cell types in lung tissue from subjects with pulmonary fibrosis compared with controls. Read More
J Biol Chem 2018 Dec 15. Epub 2018 Dec 15.
Structural Biology, The Walter and Eliza Hall Institute of Medical Research, Australia.
The membrane-associated RING-CH (MARCH) family of membrane-bound E3 ubiquitin ligases regulates the levels of cell-surface membrane proteins, many of which are involved in immune responses. Although their role in ubiquitin-dependent endocytosis and degradation of cell-surface proteins is extensively documented, the features of MARCH proteins and their substrates that drive the molecular recognition events leading to ubiquitin transfer remain poorly defined. In this study, we sought to determine the features of human MARCH9 that are required for regulating the surface levels of its substrate proteins. Read More
Conscious Cogn 2018 Dec 12;67:86-97. Epub 2018 Dec 12.
Fondazione Santa Lucia, IRCCS, Rome, Italy; SCNLab, Department of Psychology, University of Rome "La Sapienza", Rome, Italy. Electronic address:
Observing others' pain may induce a reaction called personal distress that may be influenced by top-down (imagine self or other in pain, i.e., self- vs other-oriented stance) and bottom-up (physical perspective of those who suffer, i. Read More
Neuroimage 2018 Dec 13. Epub 2018 Dec 13.
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
The goal of this study was to develop a molecular biomarker for the detection of protein aggregation involved in Alzheimer's disease (AD) by exploiting the features of the water saturation transfer spectrum (Z-spectrum), the CEST signal of which is sensitive to the molecular configuration of proteins. A radial-sampling steady-state sequence based ultrashort echo time (UTE) readout was implemented to image the Z-spectrum in the mouse brain, especially the contributions from mobile proteins at the frequency offsets for the composite protein amide proton (+3.6 ppm) and aliphatic proton (-3. Read More
Eur J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.
Multiphase Flow Systems (MPS), Institute of Process Engineering, Otto-von-Guericke-University (OvGU) Magdeburg, Zeppelinstraße 1, D-06130 Halle (Saale), Germany.
For about 15 years the performance of dry powder inhalers (DPIs) has been numerically analysed through CFD (computational fluid dynamics) approaches with the objective of understanding the evolving flow structures and the resulting transport of drug particles. Naturally the main interest is the numerical prediction of the emitted fine particle fraction (FPF) which is able to penetrate the lung airways. Due to the mostly used drug formulations (i. Read More
J Theor Biol 2018 Dec 13. Epub 2018 Dec 13.
Department of Mathematics, Kennesaw State University, 370 Paulding Ave. NW Kennesaw. GA 30144, UK.
Modelling enzyme kinetics has a long history, as one of the earliest areas where mathematics was utilized to understand biological (in this case, biochemical) phenomena. By using differential equations and the law of mass action, many researchers have discovered information about the mechanisms of enzyme workings in the more than 100 years since Leonor Michaelis and Maud Menten published their classic paper in 1913. This work uses the laws obeyed by molecules during a reaction, translates them into mathematical equations, and then compares the results predicted by the equations to data obtained in laboratory conditions. Read More
Dev Cogn Neurosci 2018 Nov 20. Epub 2018 Nov 20.
Center for Mind and Brain, University of California, Davis, CA, 95616, USA; Department of Psychology, University of California, Davis, CA, 95616, USA. Electronic address:
The current study investigated longitudinal change in hippocampal and prefrontal contribution to episodic retrieval. Functional neuroimaging data were collected during an item-context association memory task for children between the ages of 8 and 14 with individuals scanned 1-3 times over the course of 0.75-3. Read More
Appl Radiat Isot 2018 Dec 5. Epub 2018 Dec 5.
Department of Molecular Bioscience, Centre for Radiation Protection Research, The Wenner-Gren Institute, Stockholm University, Universitetsvagen 10, 114 18 Stockholm, Sweden; Jan Kochanowski University, Institute of Biology, ul. Świętokrzyska 15, 25-406 Kielce, Poland.
The relative biological effectiveness (RBE) values were determined for single- and mixed-ion beams containing carbon and oxygen ions. The CHO-K1 cells were irradiated with beams with the linear energy transfer (LET) values of 236-300 and 461-470 keV/μm for C and O ions, respectively. The RBE was estimated as a function of dose, survival fraction (SF) and LET. Read More
J Chromatogr A 2018 Nov 23. Epub 2018 Nov 23.
Department of Pharmaceutical Chemistry, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, Belgrade 11000, Serbia.
Investigation of the retention behavior of a wide range of analytes, 43 nitrogen containing heterocyclic and guanidine derivatives such, as imidazoline and serotonin receptor ligands or their related compounds, was performed on mixed-mode stationary phase in the combined reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) modes. Suitability of the linear retention modelling in the HILIC and RP modes was tested including separate contributions from adsorption and partition. For the HILIC retention, the partition model was found to provide better description compared with the adsorption model. Read More
Carbohydr Polym 2019 Feb 29;206:511-519. Epub 2018 Oct 29.
School of Pharmacy, Queen's University of Belfast, Belfast, Antrim, Northern Ireland, United Kingdom.
In this study the relationship between the viscoelasticity/mechanical properties of metronidazole-containing aqueous polymer networks composed of HEC and PVP and drug release was statistically modelled. The networks were characterised using oscillatory analysis and drug release was performed using dissolution analysis (pH 7.4). Read More
J Chem Phys 2018 Dec;149(22):225101
Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7c, 6525ED Nijmegen, The Netherlands.
The biological activity of the macrocycle nonactin is intimately related to its ionophore properties and ability to act as a selective cation carrier. The competitive binding of small protonated amines constitutes a particularly key issue in the biochemistry of nonactin, which finds application in sensing and extraction technologies. In this study, isolated complexes of nonactin with ammonium and hydroxylammonium are investigated with infrared action spectroscopy and quantum chemical computations. Read More
Clin Biochem 2018 Dec 12. Epub 2018 Dec 12.
RCPA Quality Assurance Programs, St Leonards, Sydney, NSW, Australia 2065. Electronic address:
Background: To minimise the risk of patient harm from results, laboratories should establish QC strategies and monitor the performance of assays in line with the analytical and clinical risk.
Methods: Steady state errors were calculated from a distribution normalized for an Analytical Performance Specification expressed as Assay Capability (imprecision) minus Assay Stability (drift). Inverting this error rate gave QC run length containing one error. Read More
Genes Brain Behav 2018 Dec 15:e12547. Epub 2018 Dec 15.
Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Individuals with autism constitute a variable population whose members are spread along the autism spectrum. Sub-populations within that spectrum exhibit other conditions, such as anxiety, intellectual disabilities, hyperactivity and epilepsy, with different severities and co-occurrences. Among the genes associated with the increased risk for autism is the methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, which impairs one-carbon metabolic pathway efficiency. Read More
Am J Community Psychol 2018 Dec 14. Epub 2018 Dec 14.
Pacifica Graduate Institute, Carpinteria, CA, USA.
Community psychology's history has traditionally been described within the context of U.S. history, silencing contributions from people of color from the Americas, Asia, the Pacific Islands, and Africa. Read More
Nurs Outlook 2018 Nov 23. Epub 2018 Nov 23.
School of Nursing & Midwifery, Edith Cowan University, Joondalup Campus, Perth, Australia.
Objectives: To offer practical guidance to nurse investigators interested in multidisciplinary research that includes assisting in the development of artificial intelligence (AI) algorithms for "smart" health management and aging-in-place.
Methods: Ten health-assistive Smart Homes were deployed to chronically ill older adults from 2015 to 2018. Data were collected using five sensor types (infrared motion, contact, light, temperature, and humidity). Read More
Curr Opin Insect Sci 2018 Oct 26;29:12-20. Epub 2018 May 26.
Department of Electrical and Computer Engineering, TAMU, College Station, TX 77843-3128, United States.
Regulation of many physiological processes in animals, certainly those controlled by neuropeptide hormones, involves G protein-coupled receptors (GPCRs). Our work focusing on endocrine regulation of diuresis and water balance in mosquitoes and ticks started in 1997 with the kinin receptor, at the dawn of the omics era. After the genomic revolution, we began work on the endocrinology of reproduction in the red imported fire ant. Read More
Curr Opin Insect Sci 2018 Aug 16;28:98-104. Epub 2018 May 16.
Department of Entomology, 2475 TAMU, Texas A&M University, College Station, TX 77843, USA.
Citizen-collected arthropod vectors are useful for epidemiological studies of vector-borne disease, especially since the vectors encountered by the public are the subset of vectors in nature that have a disproportionate impact on health. Programs integrating educational efforts with collecting efforts may be particularly effective for public health initiatives, resulting in an empowered public with knowledge of vector-borne disease prevention. Citizen science programs have been successfully implemented for the collection of unprecedented sample sets of mosquitos, ticks, and triatomines. Read More
Curr Opin Insect Sci 2018 Aug 14;28:50-58. Epub 2018 May 14.
Department of Evolutionary Ecology, Institute of Organismic and Molecular Evolution, Johannes Gutenberg-University Mainz, Johann-Joachim-Becher-Weg 13, 55128 Mainz, Germany. Electronic address:
Symbiotic microbes can confer a range of benefits to social, sub-social, and gregarious insects that include contributions to nutrition, digestion, and defense. Transmission of beneficial symbionts to the next generation in these insects sometimes occurs transovarially as in many solitary insects, but primarily through social contact such as coprophagy in gregarious taxa, and trophallaxis in eusocial insects. While these behaviors benefit reliable transmission of multi-microbial assemblages, they may also come at the cost of inviting the spread of parasites and pathogens. Read More
Genes (Basel) 2018 Dec 13;9(12). Epub 2018 Dec 13.
Department of Plant and Environmental Sciences, Institute for Life Sciences, Edmond J. Safra Campus, Givat Ram, Hebrew University, Jerusalem 91904, Israel.
Studies are increasingly showing that metabolic and circadian (~24 h) pathways are strongly interconnected, with the circadian system regulating the metabolic state of the cell, and metabolic products feeding back to entrain the oscillator. In plants, probably the most significant impact of the circadian system on metabolism is in its reciprocal regulation of photosynthesis; however, the pathways by which this occurs are still poorly understood. We have previously shown that members of the basic helix-loop-helix (bHLH) transcription factor PHYTOCHROME INTERACTING FACTOR (PIF) family are involved in the photosynthate entrainment of the circadian oscillator. Read More
Int J Environ Res Public Health 2018 12 13;15(12). Epub 2018 Dec 13.
Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
The prevalence of frailty at population-level is expected to increase in Europe, changing the focus of Public Health. Here, we report on the activities of the A3 Action Group, focusing on managing frailty and supporting healthy ageing at community level. A three-phased search strategy was used to select papers published between January 2016 and May 2018. Read More
Metabolites 2018 Dec 13;8(4). Epub 2018 Dec 13.
Arthritis Program, University Health Network, Toronto, ON M5T 2S8, Canada.
Osteoarthritis (OA) is a progressive, deteriorative disease of articular joints. Although traditionally viewed as a local pathology, biomarker exploration has shown that systemic changes can be observed. These include changes to cytokines, microRNAs, and more recently, metabolites. Read More
FEMS Microbiol Ecol 2018 Dec 14. Epub 2018 Dec 14.
Marine Biological Association of the United Kingdom, The Laboratory, Citadel Hill, Plymouth, PL1 2PB.
Sediment nitrogen cycling is a network of microbially-mediated biogeochemical processes that are vital in regulating ecosystem functioning. Mucopolysaccharides (mucus) are produced by many invertebrates and have the potential to be an important source of organic carbon and nitrogen to sediment microorganisms. At present, we have limited understanding of how mucopolysaccharide moderates total sediment microbial communities and specific microbial functional groups that drive nitrogen cycling processes. Read More
Curr Opin Chem Biol 2018 Dec 11;49:97-104. Epub 2018 Dec 11.
Heterogeneous biocatalysis laboratory, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH-CSIC), University of Zaragoza, C/ Pedro Cerbuna 12, 50009, Zaragoza, Spain; ARAID, Aragon I+D foundation, Zaragoza, Spain. Electronic address:
During the past decades, biocatalysis has made important contributions to chemical manufacturing by using both whole-cell and cell-free biotransformation reactions. More recently, multi-enzyme systems that can run step-wise reactions in one-pot with high selectivity are increasingly being developed. The use of multiple isolated enzymes to perform a series of reactions offers operational and process advantages over the use of living or resting cells, but such cell free processes need to be optimized to meet industrial productivity and titer requirements. Read More
Child Abuse Negl 2018 Dec 11;88:266-274. Epub 2018 Dec 11.
Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States.
Background: Evidence-based, patient-specific estimates of abusive head trauma probability can inform physicians' decisions to evaluate, confirm, exclude, and/or report suspected child abuse.
Objective: To derive a clinical prediction rule for pediatric abusive head trauma that incorporates the (positive or negative) predictive contributions of patients' completed skeletal surveys and retinal exams.
Participants And Setting: 500 acutely head-injured children under three years of age hospitalized for intensive care at one of 18 sites between 2010 and 2013. Read More
Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 28;211:227-233. Epub 2018 Nov 28.
Beijing Bioprocess Key Laboratory, Beijing University of Chemical Technology, Beijing 100029, PR China; College of Science, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:
The production of 1,3-propanediol (1,3-PDO) is an important fermentation process. However, 1,3-PDO could not be distinguished separately and efficiently in fermentations previously because it has a highly similar molecular structure to the feedstock glycerol (GLY) and by-product lactic acid (Lac), which leads to the difficulty of quantification. In this paper, a low-cost and environmentally friendly biosensor based on surface-enhanced Raman scattering (SERS) technique was developed. Read More
Virology 2018 Dec 11;528:7-18. Epub 2018 Dec 11.
Department of Microbiology & Immunology, Vagelos College of Physicians & Surgeons of Columbia University, 701 W. 168th St., New York, NY 10032, USA. Electronic address:
The contributions of RIG-I and MDA5 receptors to sensing viruses of the Picornaviridae family were investigated. The picornaviruses encephalomyocarditis virus (EMCV) and Coxsackievirus B3 (CVB3) are detected by both MDA5 and RIG-I in bone marrow derived macrophages. In macrophages from wild type mice, type I IFN is produced early after infection; IFNβ synthesis is reduced in the absence of each sensor, while IFNα production is reduced in the absence of MDA5. Read More
Brain Behav Immun 2018 Dec 11. Epub 2018 Dec 11.
Departament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, Catalonia, 08193, Spain. Electronic address:
Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions by signaling through six known G-protein-coupled receptors (LPA-LPA). In the central nervous system (CNS), LPA mediates a wide range of effects, including neural progenitor cell physiology, astrocyte and microglia activation, neuronal cell death, axonal retraction, and contributions to pain, schizophrenia and hydrocephalus. We recently reported that LPA-LPA signaling mediates functional deficits and myelin loss after spinal cord injury (SCI). Read More
Sci Total Environ 2018 Dec 3;657:535-547. Epub 2018 Dec 3.
State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Department of Sediment Research, China Institute of Water Resource and Hydropower Research, Beijing 100048.
In semiarid terrestrial ecosystems, optimized eco-rehabilitation strategies, such as land preparations and planting vegetation, are keys to achieve a successful ecological restoration. Land preparations and vegetation are supposed to have the coupled and respective impacts on soil ecosystem services, which are still unclear now. In this study, eighteen experimental plots with six different combinations and repetitions of land preparations and vegetation were built in the Chinese Loess Plateau in 2014 and soil moisture storages (SMS), soil carbon stocks (SCS) and other soil nutrient stocks were calculated at 0-100 cm, also the effects of land preparations and planting vegetation on soil eco-hydrological services are analyzed by mathematical methods. Read More