111,766 results match your criteria Contraceptive Technology Update [Journal]


Fms-like tyrosine kinase 3 is a key factor of male fertility.

Theriogenology 2018 Dec 8;126:145-152. Epub 2018 Dec 8.

Department of Animal Science & Technology, Chung-Ang University, Anseong, Gyeonggi-Do, 17546, Republic of Korea. Electronic address:

Fms-like tyrosine kinase 3 (FLT3) is a type III kinase that is highly expressed in seminal plasma of infertile men. FLT3 activation can be blocked by inhibition of its phosphorylation using the nontoxic and selective inhibitor, quizartinib. We investigated the function of FLT3 and the corresponding effects of quizartinib in mouse spermatozoa. Read More

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December 2018
1 Read

Corrigendum: Factors related to married or cohabiting women's decision to use modern contraceptive methods in Mafikeng, South Africa.

Afr J Prim Health Care Fam Med 2018 Dec 11;10(1):1998. Epub 2018 Dec 11.

School of Health Science, University of Venda, South Africa; and, Population and Health Research Focus Area, Faculty of Human and Social Sciences, North-West University.

No abstract available. Read More

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December 2018

Elagolix for endometriosis: all that glitters is not gold.

Hum Reprod 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Via Commenda, 12, 20122 Milan, Italy.

Elagolix, an orally active non-peptidic GnRH antagonist, has been approved by the Food and Drug Administration for the management of moderate to severe pain associated with endometriosis. As the degree of ovarian suppression obtained with elagolix is dose-dependent, pain relief may be achieved by modulating the level of hypo-oestrogenism while limiting side effects. Elagolix may thus be considered a novelty in terms of its endocrine and pharmacological properties but not for its impact on the pathogenic mechanisms of endometriosis, as the target of this new drug is, yet again, alteration of the hormonal milieu. Read More

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December 2018
2 Reads

Research Update and Opportunity of Non-hormonal Male Contraception: Histone Demethylase KDM5B-Based Targeting.

Pharmacol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Animal Science & Technology and BET Research Institute, Chung-Ang University, Anseong, Gyeonggi-do, 17546, Republic of Korea. Electronic address:

With the continued increase in global human population, diverse contraception approaches have become increasingly essential, including non-hormonal male contraception. Non-hormonal approaches to contraception are very convenient; however, such options are limited because data regarding the identification and characterization of tissue/cell-specific targets and appropriate small molecule candidate contraceptives are lacking. Based on in-silico studies of genomics, transcriptomics, and proteomics, performed by mining datasets in PubMed, we first reviewed testis-, epididymis-, and germline cell-specific genes/proteins, with the aim of presenting evidence that many of these could become 'druggable' targets for the development of non-hormonal male contraceptives in the future. Read More

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December 2018

Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2 proteins related to calcium ion entry and acrosomal acidification in asthenozoospermic males.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address:

Aims: Idiopathic nature of male infertility disorder needs to be investigated by different horizons of molecular biology for its treatment and to device male contraceptive. Further, it can also aid in advancement of assisted reproductive technology (ART), as nowadays the failure and disquiets of ART are consistent. Herein, we have attempted to find out proteins responsible for male infertility by comparing proteome profile of sperms collected from normal control and asthenozoospermic (AS) males. Read More

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December 2018

Psychometric Evaluation of an Instrument to Measure Prospective Pregnancy Preferences: The Desire to Avoid Pregnancy Scale.

Med Care 2018 Dec 13. Epub 2018 Dec 13.

Department of Obstetrics, Gynecology and Reproductive Sciences, Bixby Center for Global Reproductive Health, Advancing New Standards in Reproductive Health (ANSIRH), University of California, San Francisco, School of Medicine, San Francisco.

Background: Existing approaches to measuring women's pregnancy intentions suffer important limitations, including retrospective assessment, overly simple categories, and a presumption that all women plan pregnancies. No psychometrically valid scales exist to prospectively measure the ranges of women's pregnancy preferences.

Materials And Methods: Using a rigorous construct modeling approach, we developed a scale to measure desire to avoid pregnancy. Read More

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December 2018
1 Read

Contraceptive Use Among Women with Prediabetes and Diabetes in a US National Sample.

J Midwifery Womens Health 2018 Dec 12. Epub 2018 Dec 12.

Introduction: Although elevated blood glucose is associated with adverse maternal and fetal health outcomes, evidence suggests that women with diabetes may not be receiving comprehensive reproductive health care, including family planning and preconception care. Using a population-based sample, we evaluated the relationship between contraceptive use and biomarker-identified diabetes.

Methods: This cross-sectional study used data from 5548 women in the nationally representative National Longitudinal Study of Adolescent to Adult Health (Add Health) from 2007 to 2009. Read More

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December 2018

Assessment of women's satisfaction with family planning service at public health facilities in Northwest Region of Ethiopia: a cross sectional study.

Contracept Reprod Med 2018 6;3:25. Epub 2018 Dec 6.

3Department of Epidemiology and Biostatistics', School of Public Health, Bahir Dar University, Bahir Dar, Ethiopia.

Background: Ethiopia is a Sub Saharan African country with an estimated contraceptive prevalence rate of 36% and 22% unmet need for family planning service among married women. Client satisfaction influences the use of Family Planning and other reproductive health services. There is limited information on satisfaction with family planning service among Family planning users particularly in the northern part of Ethiopia. Read More

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December 2018
4 Reads

Dietary intake of nutrients involved in folate-mediated one-carbon metabolism and risk for endometrial cancer.

Int J Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

Background: Studies disagree as to whether intakes of folate-mediated one-carbon metabolism nutrients are associated with endometrial cancer.

Methods: Using data from the large, prospective NIH-AARP Diet and Health Study, we used Cox proportional hazards models to evaluate endometrial cancer risk associated with calorie-adjusted dietary intake of several B vitamins and methionine. All models accounted for age, race, body mass index (BMI), smoking, oral-contraceptive use, menopausal hormone therapy use and caloric intake. Read More

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December 2018

The multi-country PROMOTE HIV antiretroviral treatment observational cohort in Sub-Saharan Africa: Objectives, design, and baseline findings.

PLoS One 2018 13;13(12):e0208805. Epub 2018 Dec 13.

Johns Hopkins School of Medicine, Baltimore, MD, United States of America.

Background: The PROMOTE study aims to measure long-term antiretroviral treatment (ART) safety and adherence; compare HIV disease progression; assess subsequent adverse pregnancy outcomes; evaluate effect of ART exposure on growth and development in HIV-exposed uninfected children; and assess long-term survival of mothers and children. This report primarily describes cohort characteristics at baseline to better understand long-term outcomes.

Methods And Findings: This is a prospective study. Read More

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December 2018

Assessment of country policies affecting reproductive health for adolescents in the Philippines.

Reprod Health 2018 Dec 12;15(1):205. Epub 2018 Dec 12.

Department of Reproductive Health and Research/ Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organization, Geneva, Switzerland.

Background: Adolescents in the Philippines face many legal, social and political barriers to access sexual and reproductive health (SRH) services, putting them at higher risk of unplanned pregnancy, abortion, sexually transmitted infections and HIV, and other health and development problems.

Objective: This study aims to evaluate whether current normative documents on SRH in the Philippines are in concurrence with adolescents' human rights principles using the World Health Organization (WHO) Guidance and Recommendations on ensuring human rights in the provision of contraceptive information and services.

Methods: The review focused on policies and normative guidance documents which included the national reproductive health law, its implementing rules and regulations, and the Supreme Court decisions on the law, and documents cited in the government's Adolescent and Youth Health Programme. Read More

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December 2018

Quality of care in family planning services in rural Mozambique with a focus on long acting reversible contraceptives: a cross-sectional survey.

BMC Womens Health 2018 Dec 12;18(1):201. Epub 2018 Dec 12.

International Centre for Reproductive Health, Ghent University, Corneel Heymanslaan 10, UZP 114, 9000, Ghent, Belgium.

Background: In Mozambique, both the government and partners have undertaken efforts over the last decade to improve FP (family planning) services, especially through training health care providers and promoting the uptake of LARCs (Long Acting Reversible Contraceptives). Despite this, uptake of FP methods has not increased significantly. This study aims to examine women's knowledge on LARCs, including their main sources of information, and the quality of care of FP services in rural areas. Read More

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December 2018

Dimensions of Reproductive Attitudes and Knowledge Related to Unintended Childbearing Among U.S. Adolescents and Young Adults.

Demography 2018 Dec 6. Epub 2018 Dec 6.

Department of Systems, Populations and Leadership, School of Nursing, University of Michigan, 400 N. Ingalls Street, Ann Arbor, MI, 48109, USA.

Measures of attitudes and knowledge predict reproductive behavior, such as unintended fertility among adolescents and young adults. However, there is little consensus as to the underlying dimensions these measures represent, how to compare findings across surveys using different measures, or how to interpret the concepts captured by existing measures. To guide future research on reproductive behavior, we propose an organizing framework for existing measures. Read More

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December 2018
1 Read

Progress in Developing Pharmacologic Agents to Treat Bulimia Nervosa.

CNS Drugs 2018 Dec 6. Epub 2018 Dec 6.

Lindner Center of HOPE, Mason, OH, USA.

This paper reviews past and current progress in developing pharmacologic agents for the treatment of individuals with bulimia nervosa (BN). We searched the literature and clinical trial registries for compounds studied in BN, the related condition, binge eating disorder (BED), and preclinical models of binge-eating behavior. Drug classes evaluated included antidepressants, antiepileptic drugs, stimulants and other medications for attention-deficit/hyperactivity disorder, opioid antagonists, and weight loss agents, among others. Read More

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December 2018

Delivering postpartum family planning services in Nepal: are providers supportive?

BMC Health Serv Res 2018 Dec 6;18(1):948. Epub 2018 Dec 6.

Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Background: Health service providers play a key role in addressing women's need for pregnancy prevention, especially during the postpartum period. Yet, in Nepal, little is known about their views on providing postpartum family planning (PPFP) services and postpartum contraceptive methods such as immediate postpartum intra-uterine devices (PPIUD). This paper explores the perspectives of different types of providers on PPFP including PPIUD, their confidence in providing PPFP services, and their willingness to share their knowledge and skills with colleagues after receiving PPFP and PPIUD training. Read More

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December 2018

The logistics of voucher management: the underreported component in family planning voucher discussions.

J Multidiscip Healthc 2018 22;11:683-690. Epub 2018 Nov 22.

Research, Monitoring and Evaluation Department, Technical Services, Marie Stopes Society, Karachi, Sindh, Pakistan.

Background: The purpose of health care vouchers or coupons is to receive a health service in exchange which is fully or partially subsidized, such as any treatment offered for communicable disease; for immunization; antenatal care-/postnatal care-related maternal health services; a family planning (FP) service; or to get a health commodity like a medicine. Vouchers are targeted for a group of people who can benefit the most such as on the basis of poverty ranking, marginalized or living in rural areas. According to the World Health Organization, voucher schemes in the area of sexual and reproductive health are considered of high value if they are implemented to address the issues of contraceptive commodity or service unavailability or to address the barriers to access such services through contracting out health services, for example, through social franchising (SF). Read More

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November 2018

A case of a young, healthy woman with spontaneous coronary artery dissection associated with oral contraceptive use: Long-term residual dissection of the coronary artery.

J Cardiol Cases 2013 Dec 29;8(6):179-182. Epub 2013 Oct 29.

Department of Cardiology, National Hospital Organization, Kure Medical Center Chugoku Cancer Center, 3-1 Aoyama-cho, Kure, Hiroshima 737-0023, Japan.

Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome, typically affecting young, healthy women, particularly during the peripartum period. Oral contraceptive use is also recognized as a risk factor for SCAD. In the present report, we describe a case of a young woman with an anterior wall myocardial infarction caused by SCAD of the left anterior descending artery (LAD). Read More

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December 2013

Local injection of tissue-plasminogen activator using a pulse spray catheter as a treatment option for proximal deep vein thrombosis: A case report.

J Cardiol Cases 2014 Nov 27;10(5):163-166. Epub 2014 Jun 27.

Showa University Northern Yokohama Hospital, Division of Cardiology and Cardiac Catheterization Laboratories, Yokohama, Japan.

A 24-year-old woman was admitted to our hospital with the diagnosis of pulmonary thromboembolism (PTE) and left common iliac vein thrombosis. She had used low-dose contraceptive pill for dysmenorrhea. Otherwise, her laboratory data did not show any other thrombotic risk factors. Read More

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November 2014
1 Read

Multivessel spontaneous coronary artery dissection associated with hormonal infertility therapy in a 39-year-old female.

J Cardiol Cases 2012 Apr 6;5(2):e69-e72. Epub 2012 Mar 6.

Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Spontaneous coronary artery dissection (SCAD) is a rare and potentially lethal cause of chest pain and myocardial infarction in healthy young individuals. It more commonly affects females and has been correlated with hormonally-induced connective tissue changes in pregnancy and oral contraceptive use. We present the case of a previously healthy 39-year-old woman with multivessel SCAD associated with recent clomiphene and gonadotropin therapy for infertility, which is not a previously reported association, and we assert that this should be in the differential diagnosis of such patients with chest pain or myocardial infarction. Read More

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Facilitators and Barriers to Contraceptive Use Among U.S. Servicewomen Who Had an Abortion.

Mil Med 2018 Dec 7. Epub 2018 Dec 7.

Ibis Reproductive Health, 2067 Massachusetts Avenue, Cambridge, MA.

Introduction: Despite evidence that the unintended pregnancy rate is higher among U.S. servicewomen than the general population and that servicewomen may face barriers to contraceptive use, there is little research about contraceptive access and use experiences of non-deployed active duty servicewomen. Read More

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December 2018
3 Reads

Reproductive Health Care in Catholic Facilities: A Scoping Review.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

University of Colorado School of Medicine, and the Center for Bioethics and Humanities and Health Sciences Library, University of Colorado Anschutz Medical Center, Aurora, Colorado.

Objective: Given the rise in Catholic ownership of U.S. health care facilities, we aimed to examine reproductive health care provision and patient outcomes. Read More

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December 2018

Five-Year Contraceptive Efficacy and Safety of a Levonorgestrel 52-mg Intrauterine System.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Department of Obstetrics and Gynecology, University of Colorado, Aurora, Colorado; the Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah; the Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh, Pennsylvania; the Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia; Medicines360, San Francisco, California; and the Department of Obstetrics and Gynecology, University of California, Davis, Sacramento, California.

Objective: To assess the 5-year contraceptive efficacy and safety of a levonorgestrel (LNG) 52-mg intrauterine system (IUS) from an ongoing 10-year phase 3 contraceptive trial.

Methods: Study investigators enrolled 1,751 nulliparous and parous females aged 16-45 years and desiring contraception to receive a novel LNG 52-mg IUS at 29 centers in the United States, including reproductive health clinics, private offices, and university centers. Participants had scheduled follow-up visits four times during the first year. Read More

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December 2018
3 Reads

Effects of Two Educational Posters on Contraceptive Knowledge and Intentions: A Randomized Controlled Trial.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Health Policy and Management, Family Medicine, and Maternal and Child Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Objective: To compare the Centers for Disease Control and Prevention's (CDC) contraceptive effectiveness poster with a more patient-centered poster on factors affecting the likelihood of using effective contraceptives.

Methods: The posters were tested in a randomized controlled trial. Women were eligible if they were aged 18-44 years, could speak and read English, were not pregnant or trying to conceive, and had engaged in vaginal intercourse in the past 3 months. Read More

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December 2018

Hybrid simulation training: An effective teaching and learning modality for intrauterine contraceptive device insertion.

Educ Health (Abingdon) 2018 May-Aug;31(2):119-124

Department of Obstetrics and Gynecology, Aga Khan University Hospital, Karachi, Pakistan.

Background: Hybrid simulation training (HST) is a teaching modality that combines patient interaction using simulated patient (SP) with pelvic model. This provides realism to learners, lacking in manikins alone. This study was designed to compare knowledge, procedural, and communication skills of medical students regarding intrauterine contraceptive device (IUCD) insertion before and after introducing HST and to assess learner satisfaction with this methodology. Read More

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December 2018
1 Read

Recurrent Mondor's breast disease - hormonal contraceptive involvement.

Breast Dis 2018 Sep 19. Epub 2018 Sep 19.

xx, xx, xx.

Mondor's disease can be a challenging diagnosis. The case we present is of a 29 year-old Brazilian woman, under combined hormonal contraception, who consulted for a painful lump on her right breast. She presented a complete resolution after a local treatment of heparinoid cream and a non-steroidal anti-inflammatory oral treatment, but relapsed 18 months later. Read More

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September 2018

Understanding Commercially Sexually Exploited Youths' Facilitators and Barriers Towards Contraception Use: I Didn't Really Have A Choice.

J Pediatr Adolesc Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, David Geffen School of Medicine at UCLA and Mattel Children's Hospital, Los Angeles, CA, phone: (310) 206-1483, fax: (310) 206-4855, UCLA Pediatrics, Box 951752m 12-467 MDCC, Los Angeles, CA, United States, 90095-1752. Electronic address:

Study Objective: Given the high reproductive health risks that commercially sexually exploited youth (CSEY) face, we sought to understand facilitators and barriers related to their utilization of both condoms and hormonal contraception.

Design: We conducted semi-structured interviews with 21 females identified as CSEY. Interviews were audio-recorded, transcribed, and coded for emergent themes. Read More

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December 2018

Levonorgestrel Intrauterine System associated amenorrhea: a systematic review and meta-analysis.

Am J Obstet Gynecol 2018 Dec 7. Epub 2018 Dec 7.

FHI 360, Contraceptive Technology Innovation, 359 Blackwell Street, Suite #200, Durham, North Carolina, 27701 United States.

Background: Amenorrhea is a polarizing non-contraceptive effect of the Levonorgestrel Intrauterine System (LNG-IUS). Composite amenorrhea prevalence estimates summarizing all clinical data for the first-year post-insertion is currently not available.

Objective: To investigate the validity of existing prevalence estimates by systematically calculating amenorrhea measures for a general population of LNG-IUS users and provide 90-day interval point estimates for the first-year of use. Read More

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December 2018

Issues about periconception use of dolutegravir are reminiscent of early concerns about efavirenz.

Lancet HIV 2018 Dec;5(12):e732-e736

Center for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

South Africa intends to include dolutegravir in its first-line antiretroviral therapy (ART) regimen because of cost savings, the drug's high barrier to resistance, and efficacy. However, recent data from Botswana suggest potential teratogenicity of dolutegravir. WHO recommends that non-pregnant women of childbearing age who are not using an effective form of contraception and women in early pregnancy should not initiate treatment with dolutegravir. Read More

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December 2018

Contraceptive use and the risk of sexually transmitted infection: systematic review and current perspectives.

Open Access J Contracept 2018 12;9:91-112. Epub 2018 Nov 12.

Global Health, Population and Nutrition, FHI 360, Durham, NC, USA,

Purpose: Evidence on the association between contraceptive use and risk of sexually transmitted infections (STIs) and bacterial vaginosis (BV) is lacking, with few prospective studies. We systematically reviewed the last 10 years' evidence on the association between contraception and STI/BV, building on the most recent systematic reviews published in 2006 and 2009.

Methods: We searched the MEDLINE and POPLINE databases for peer-reviewed articles p ublished between January 1, 2008 and January 31, 2018 reporting prospective studies that assessed the association between contraceptive use and incident STI and/or incident or recurrent BV. Read More

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November 2018
2 Reads

Programmatic implications of unmet need for contraception among men and young married women in northern Nigeria.

Open Access J Contracept 2018 8;9:81-90. Epub 2018 Nov 8.

UKAid/Nigeria MNCH2 Programme, Kano, Nigeria.

Purpose: The study was designed to provide programmatic recommendations for interventions to increase contraceptive prevalence in northern Nigeria. Family-planning use in North-East and North-West regions of Nigeria has remained very low, despite years of domestic and donor investments. We examine respondents' perceptions of their own need for contraception and specifically focus on young women because of their higher risk for maternal mortality. Read More

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November 2018
1 Read

Venous thrombosis and hormonal contraception: what's new with estradiol-based hormonal contraceptives?

Open Access J Contracept 2018 8;9:75-79. Epub 2018 Nov 8.

Institute of Obstetrics and Gynecology, Department of Medical Area, University of Udine, Udine, Italy.

Objective: Estradiol (E2)-based hormonal contraceptives impact less than ethinylstradiol (EE) contraceptives on venous thromboembolism (VTE) in comparison to formulations with EE.

Study Design: In this article, the pharamacologic data of EE and E2 were briefly reviewed, along with the induced biologic effect. These data were then related to a recent large international prospective, controlled, non-interventional cohort active surveillance study, on the cardiovascular risk of users of different types of combined estroprogestin contraceptive (CEPC). Read More

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November 2018
1 Read

Postpartum family-planning barriers and catalysts in Burkina Faso and the Democratic Republic of Congo: a multiperspective study.

Open Access J Contracept 2018 9;9:63-74. Epub 2018 Nov 9.

Institut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso.

Purpose: To address the high unmet need for postpartum family planning (PPFP) in resource-limited settings, particularly in sub-Saharan Africa, this study aimed to identify PPFP-related barriers and catalysts to inform policies and programs to increase access to postpartum contraception.

Methods: Using qualitative methodology, we explored the perspectives of women, adolescent girls, men, religious and community leaders, service providers, and decision makers from three rural communities in Burkina Faso and three rural-urban communities in the Democratic Republic of Congo. Both countries have high unmet need for PPFP and are priority countries of the French Muskoka Fund for Maternal and Child Health. Read More

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November 2018
1 Read

Utilization of long acting reversible contraceptive methods and associated factors among female college students in Gondar town, northwest Ethiopia, 2018: institutional based cross-sectional study.

BMC Res Notes 2018 Dec 5;11(1):862. Epub 2018 Dec 5.

Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Objectives: Family planning is achieved through use of different contraceptive methods among which the most effective methods are modern family planning methods like long acting reversible contraceptive which includes intra-uterine contraceptive device and Implants. The objective of this primary study was to assess utilization of long acting reversible contraceptive methods among female college students in Gondar town, northwest Ethiopia.

Results: The overall utilization of long acting reversible contraceptive methods among students was 20. Read More

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December 2018
1 Read

17α-Ethynylestradiol and 4-nonylphenol stimulate lung adenocarcinoma cell production in xenoestrogenic way.

Chemosphere 2018 Nov 20;218:793-798. Epub 2018 Nov 20.

Department and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan, ROC; Medical Center of Aging Research, China Medical University Hospital, Taichung 40402, Taiwan, ROC; Department of Biotechnology, College of Health Science, Asia University, Taichung 41354, Taiwan, ROC; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan, ROC. Electronic address:

Lung cancer has been one of the major cancers leading to mortalities worldwide. In addition to smoking, estrogen is considered to play an important role in the lung cancer development because women have a higher proportion of adenocarcinoma than men. In the environment, there are many metabolites and waste products that mimic human estrogen structurally and functionally. Read More

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November 2018
1 Read

Women's Reproductive History and Pre-Clinical Peripheral Arterial Disease in Late Life: The San Diego Population Study.

J Womens Health (Larchmt) 2018 Dec 1. Epub 2018 Dec 1.

5 Premier Applied Sciences, Premier, Inc., Charlotte, North Carolina.

Objective: Reproductive events have been linked with increased cardiovascular risk in women, but whether they are associated with pre-clinical peripheral arterial disease (PAD) has been understudied. We evaluated associations between reproductive factors and later-life ankle-brachial index (ABI), femoral artery intima-media thickness (fIMT), and femoral plaques.

Methods: Cross-sectional analysis of 707 multiethnic women who participated in a follow-up exam of the San Diego Population Study in 2007-2011. Read More

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December 2018
1 Read

A Comparison of Breastfeeding Exclusivity and Duration Rates Between Immediate Postpartum Levonorgestrel Versus Etonogestrel Implant Users: A Prospective Cohort Study.

Breastfeed Med 2018 Dec 1. Epub 2018 Dec 1.

1 Department of Obstetrics and Gynecology, University of North Carolina School of Medicine , Chapel Hill, North Carolina.

Objective: This study compares breastfeeding outcomes after immediate postpartum initiation of single-rod etonogestrel (ENG) versus two-rod levonorgestrel (LNG) contraceptive implants. Outcomes assessed include the following: (1) breastfeeding continuation through 24 months after delivery and (2) exclusive breastfeeding until 6 months after delivery, at Kasungu District Hospital, Malawi.

Methods: We used Kaplan-Meier survival analysis to compare breastfeeding continuation through 24 months and exclusive breastfeeding through 6 months after delivery for ENG versus LNG implant users. Read More

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December 2018
1 Read

Low-Income Texas Women's Experiences Accessing Their Desired Contraceptive Method at the First Postpartum Visit.

Perspect Sex Reprod Health 2018 Dec 3;50(4):189-198. Epub 2018 Dec 3.

Professor, Population Research Center, University of Texas at Austin.

Context: Early access to contraception may increase postpartum contraceptive use. However, little is known about women's experiences receiving their desired method at the first postpartum visit or how access is associated with use.

Methods: In a 2014-2016 prospective cohort study of low-income Texas women, data were collected from 685 individuals who desired a reversible contraceptive and discussed contraception with a provider at their first postpartum visit, usually within six weeks of birth. Read More

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December 2018
2 Reads

Use of oral contraceptives and risk of ulcerative colitis - A systematic review and meta-analysis.

Pharmacol Res 2018 Nov 28;139:367-374. Epub 2018 Nov 28.

Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China. Electronic address:

Numerous studies have investigated the link between oral contraceptives and risk of ulcerative colitis (UC), but the results have been controversial. We systematically reviewed all relevant published studies and evaluated the association between the use of oral contraceptives and the development of UC by meta-analysis. Databases including PubMed, EMbase, CNKI and WanFang data were thoroughly searched from inception to September 2018 to collect the studies on the correlation between oral contraceptives and the risk of UC. Read More

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November 2018

Amelioration of sperm immobilisation factor-induced infertility by bacterial antigenic determinants cross-reacting with spermatozoa.

Reprod Fertil Dev 2018 Dec 6. Epub 2018 Dec 6.

A strain of Staphylococcus aureus, capable of in vitro immobilisation of human and mouse spermatozoa, was already present in our laboratory. Therefore, in the present study, the factor responsible (sperm immobilisation factor, SIF) was isolated and purified. It was found to compromise not only motility, but also viability, morphology and Mg2+-ATPase activity of mouse spermatozoa. Read More

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December 2018
2 Reads

Analysis of sexual and reproductive health indicators of Brazilian adolescents, 2009, 2012 and 2015.

Rev Bras Epidemiol 2018 Nov 29;21(suppl 1):e180013. Epub 2018 Nov 29.

Escola de Enfermagem, Universidade Federal de Minas Gerais - Belo Horizonte (MG), Brasil.

Objective: To analyze sexual and reproductive health indicators of adolescents based on data from the National School-based Health Survey (PeNSE) in 2015, comparing them to the data from 2009 and 2012.

Methods: Cross-sectional study that has analyzed data from 9th grade students from PeNSE 2015, 2012 and 2009. We estimated prevalence and 95% confidence intervals for the following indicators: sexual initiation, condom use in the last sexual intercourse, counseling for pregnancy, sexually transmitted infections and free condoms in the three rounds of the survey. Read More

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November 2018

Association of Surgical Risk With Exogenous Hormone Use in Transgender Patients: A Systematic Review.

JAMA Surg 2018 Dec 5. Epub 2018 Dec 5.

Center for Gender Surgery, Boston Children's Hospital, Boston, Massachusetts.

Importance: A growing number of transgender patients are receiving gender-affirming hormone treatments. It is unclear whether the evidence supports the current practice of routinely discontinuing these hormones prior to surgery.

Objective: To determine how medications used in cross-sex hormone treatment (CSHT) affect perioperative risk. Read More

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December 2018
4 Reads

Management of intracranial haemorrhage, unruptured aneurysms and arteriovenous malformations during and after pregnancy.

Curr Opin Neurol 2018 Nov 30. Epub 2018 Nov 30.

Medicina Vascolare e D'Urgenza-Stroke Unit, Ospedale Santa Maria della Misericordia, Università di Perugia, Perugia, Italy.

Purpose Of Review: The absolute risk of pregnancy-associated intracranial haemorrhage (ICH) has been reported to be relatively low and often associated with high risks of life-long disabilities and mortality. The aim of this narrative review was obtaining a better understanding of the current management practices for ICH, unruptured aneurysms and/or arteriovenous malformations during pregnancy, as well as the effects of future pregnancies, and the uses of oral contraceptive or HRT.

Recent Finding: General guidelines for the management of ICH are used for pregnant women but additional expedient and thorough evaluation of foetal viability and its gestational age are requested. Read More

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November 2018
1 Read

Prevalence and Factors Associated with Teenage Pregnancy, Northeast Ethiopia, 2017: A Cross-Sectional Study.

J Pregnancy 2018 1;2018:1714527. Epub 2018 Nov 1.

Department of Health Communication and Behavioural Sciences, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Though teen age pregnancy had poor maternal and perinatal health outcomes, its magnitude and determinants are not well understood. Therefore, the aim of this study was to assess the prevalence and associated factors of teenage pregnancy in Wogedi, northeast Ethiopia.

Methods: A community-based cross-sectional study was conducted among 514 teenagers in Wogedi, northeast Ethiopia, from April to May 2017. Read More

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November 2018

Sexual Dysfunction and its Associated Factors After Delivery: Longitudinal Study in Iranian Women.

Mater Sociomed 2018 Oct;30(3):198-203

Department of Community Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, Selangor, Malaysia.

Introduction: Considering physical and emotional changes affecting women's sexual function in postpartum period.

Aim: This study was conducted to determine the sexual dysfunction and postpartum-related factors in Bandar Abbas women in 2016.

Material And Methods: This analytical cross-sectional study used systematic random sampling on 432 postpartum women referred to Bandar Abbas Healthcare Centers. Read More

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October 2018
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Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups.

Tuberculosis (Edinb) 2018 Dec 18;113:10-18. Epub 2018 Aug 18.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia. Electronic address:

Type 2 diabetes (T2D) is a prevalent risk factor for tuberculosis (TB), but most studies on TB-T2D have focused on TB patients, been limited to one community, and shown a variable impact of T2D on TB risk or treatment outcomes. We conducted a cross-sectional assessment of sociodemographic and metabolic factors in adult TB contacts with T2D (versus no T2D), from the Texas-Mexico border to study Hispanics, and in Cape Town to study South African Coloured ethnicities. The prevalence of T2D was 30. Read More

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December 2018
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Cervico-vaginal inflammatory cytokine alterations after intrauterine contraceptive device insertion: A pilot study.

PLoS One 2018 4;13(12):e0207266. Epub 2018 Dec 4.

Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, Ontario, Canada.

In a prospective study of twenty sexually transmitted infection (STI)-free women, we examined the impact of an intrauterine contraceptive device (IUCD) insertion on cervico-vaginal cytokine levels. Nine women chose the levonorgestrel-containing IUCD and eight chose a copper IUCD. A cervico-vaginal swab was collected for cytokine analysis pre-insertion and four weeks post-insertion. Read More

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December 2018

Birth outcomes after inadvertent use of category X drugs contraindicated in pregnancy: Where is the real risk?

Turk J Pediatr 2018 ;60(3):298-305

Department of Pharmacology, Celal Bayar University, Manisa, Turkey.

Öztürk Z, Ölmez E, Gürpınar T, Vural K. Birth outcomes after inadvertent use of category X drugs contraindicated in pregnancy: Where is the real risk? Turk J Pediatr 2018; 60: 298-305. Drugs contraindicated in pregnancy are medicines that should be avoided by pregnant women, since they carry a concern for teratogenicity or there is no indication for their use during pregnancy. Read More

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January 2018
3 Reads

Knowledge, attitudes and practices of East Flemish general practitioners towards subscribing LARCs for adolescents.

Facts Views Vis Obgyn 2018 Mar;10(1):39-44

International Centre for Reproductive Health, department of Uro-Gynaecology, faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185 UZP114, 9000 Gent, Belgium.

Objective: While long acting reversible contraceptives (LARCs) offer a more reliable protection against unintended pregnancies than short acting reversible methods (SARCs), their uptake among adolescents in Flanders (Belgium) is low. This study assesses to what degree general practitioners constitute a barrier for the uptake of LARCs by adolescents.

Methods: We did an online survey among 79 general practitioners in East Flanders to assess their knowledge, attitudes and behaviours related to advising and prescribing LARCs to adolescents. Read More

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Implementing Adolescent Sexual and Reproductive Health Clinical Best Practice in the Bronx, New York.

J Adolesc Health 2018 Nov 30. Epub 2018 Nov 30.

New York City Department of Health and Mental Hygiene, Bronx Neighborhood Health Action Center/Center for Health Equity, Bronx, New York. Electronic address:

Purpose: Inequitable access to quality adolescent sexual and reproductive health (ASRH) care may contribute to the high rate of teen pregnancy in the Bronx, New York. Bronx Teens Connection (BxTC), a community-wide intervention, sought to increase the number of ASRH best practices implemented and the number of females 12-19 years old receiving services by health centers in the Bronx.

Methods: To promote best practices, BxTC provided training and technical assistance to partnering health centers from 2011 to 2014. Read More

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November 2018