55,544 results match your criteria Contraception


The prevalence of modern contraceptive use and its associated socio-economic factors in Ghana: evidence from a demographic and health survey of Ghanaian men.

Authors:
S A Butame

Public Health 2019 Feb 12;168:128-136. Epub 2019 Feb 12.

Florida State University, College of Medicine, Center for Translational and Behavioral Sciences, 115 W Call Street, Tallahassee, FL 32306, USA. Electronic address:

Objective: This study estimated the prevalence of modern contraceptive use (MCU) and the sociodemographic factors associated with MCU among sexually active men in Ghana. The study is informed by the Health Belief Model, which is used as a conceptual framework for understanding MCU.

Study Design: This was a cross-sectional study of 2014 Ghana Demographic and Health Survey data. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.020DOI Listing
February 2019

Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Common Problem Drugs and How to Prescribe Them.

J Clin Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

The American College of Clinical Pharmacology, Ashburn, VA, USA.

Although the medical profession strives for safe prescribing, most medications are unique challenges even when prescribed by an experienced provider. In this article we discuss the pitfalls associated with drug interactions between commonly used antibiotics and anticoagulants, the complexities associated with the administration of novel reversible anticoagulants, the often-overlooked severe adverse drug reactions from commonly used classes of medications such as corticosteroids, the nuances of managing an acetaminophen overdose, and uncommon yet serious adverse events associated with the use of contraceptive hormone drugs. Read More

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http://dx.doi.org/10.1002/jcph.1389DOI Listing
February 2019

Implementation of Immediate Postpartum Long-Acting Reversible Contraception: Strategies for Success.

Authors:
Molly K Findley

J Womens Health (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Jacobi Medical Center, Albert Einstein College of Medicine, NYC Health + Hospitals, Bronx, New York.

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http://dx.doi.org/10.1089/jwh.2018.7613DOI Listing
February 2019

Collaboration of Care for Women with Epilepsy in their Reproductive Years.

J Womens Health (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

2 New York University School of Medicine, New York, New York.

Over half a million women of childbearing age have epilepsy, many of which will require family planning care at some point in their reproductive years. Matters relating to contraception, pregnancy, fertility, and sexual functioning are all impacted to varying degrees by the use of antiepileptic drugs (AEDs) to treat epilepsy and require active management by a woman's neurologist. It is important that a woman's obstetrician/gynecologist (OBGYN) and internist are aware of the way in which their care may be related to her epilepsy care and how this can be successfully comanaged with her neurologist. Read More

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http://dx.doi.org/10.1089/jwh.2018.7506DOI Listing
February 2019

Bone mineral density in midlife long-term users of hormonal contraception in South Africa: relationship with obesity and menopausal status.

Womens Midlife Health 2018 10;4. Epub 2018 Apr 10.

1MatCH Research Unit [Maternal, Adolescent and Child Health Research Unit], Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, 40 Dr AB Xuma Street,11th floor, Suite 1108-9,Commercial City, Durban, 4001 South Africa.

Background: In South Africa, hormonal contraception is widely used in women over the age of 40 years. One of these methods and the most commonly used is depot-medroxyprogesterone acetate (DMPA) which has been found to have a negative effect on bone mass. Limited information is available on the effect of norethisterone enanthate (NET-EN) on bone mass, and combined oral contraceptives (COCs) have not been found to be associated with loss of bone mass. Read More

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http://dx.doi.org/10.1186/s40695-018-0035-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297953PMC

'My partner was just all over her': jealousy, communication and rules in mixed-sex threesomes.

Cult Health Sex 2019 Feb 10;21(2):134-146. Epub 2018 Apr 10.

b Department of Sport, Exercise and Health , University of Winchester , Winchester , UK.

Drawing on findings from interviews with 28 men and women, this study explores experiences related to communication and jealousy in mixed-sex threesomes. Findings suggest that those in relationships often experience feelings of exclusion when engaging in threesomes, although open communication is a method by which the negative effects may be mitigated. Some couples agree on particular rules during their threesomes, symbolically demonstrating the specialness of the relationship as well as protecting it from further progression into non-monogamy. Read More

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http://dx.doi.org/10.1080/13691058.2018.1453088DOI Listing
February 2019

Factors associated with provision of depot medroxyprogesterone acetate to adolescents by U.S. health care providers.

Contraception 2019 Feb 11. Epub 2019 Feb 11.

Division of Reproductive Health, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Atlanta, GA, United States, 30341. Electronic address:

Objective: Identify factors associated with healthcare providers' frequency of depot medroxyprogesterone acetate (DMPA) provision to adolescents.

Study Design: We analyzed data from surveys mailed to a nationally representative sample of public-sector providers and office-based physicians (n=1984). We estimated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of factors associated with frequent DMPA provision to adolescents in the past year. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.01.005DOI Listing
February 2019

F5-peptide enhances the efficacy of the non-hormonal male contraceptive adjudin.

Contraception 2019 Feb 11. Epub 2019 Feb 11.

The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY 10065. Electronic address:

Objective: The bioavailability of the non-hormonal male contraceptive adjudin is low in rats due to the blood-testis barrier (BTB). This study was designed to examine if F5-peptide, an endogenously produced reversible BTB modifier, could enhance the bioavailability of adjudin to affect spermatogenesis and provide a contraceptive effect in rats while reducing systemic toxicity.

Study Design: We overexpressed F5-peptide in adult male rats (n=10 rats; with 3 or 4 rats for each of the three different experiments noted in the three regimens) by intratesticular injection of a mammalian expression vector pCI-neo (pCI-neo/F5-peptide) vs. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.01.007DOI Listing
February 2019
2.335 Impact Factor

Looking back while moving forward: A justice-based, intersectional approach to research on contraception and disability.

Contraception 2019 Feb 11. Epub 2019 Feb 11.

Georgia State University.

For the first time in the twenty-first century, we have an emerging body of research regarding contraceptive use among adult women with disabilities in the United States. We highlight key findings from population-based analyses that found higher odds of female sterilization and lower odds of long-acting reversible contraception (LARC) use among women with disabilities compared to their peers without disabilities. We consider potential reasons underlying these differences, including discriminatory attitudes and policies that restrict the sexual and reproductive autonomy of people with disabilities. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.01.006DOI Listing
February 2019

Claims for contraceptive services among young women filling chronic opioid prescriptions.

Contraception 2019 Feb 11. Epub 2019 Feb 11.

Division of Pharmaceutical Evaluation and Policy, Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:

Objective: To describe claims for contraceptive services among reproductive aged women filling chronic opioid prescriptions.

Study Design: Using a large US commercial claims database, IMS Lifelink+, we identified women aged 15-44years who filled chronic opioid prescriptions (defined as a 90day supply of opioids without a 30day gap over a 180day time period) and had continuous pharmacy and medical enrollment for at least 90days prior to and 180days following their index opiod prescription. After excluding women with any claims for pregnancy-related services, we describe claims for contraceptive prescriptions and used multivariable logistic regression to identify variables associated with women filling chronic opioids without any contraceptive claims. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.01.004DOI Listing
February 2019

Cluster Randomized Trial of a Patient-Centered Contraceptive Decision Support Tool, My Birth Control.

Am J Obstet Gynecol 2019 Feb 11. Epub 2019 Feb 11.

Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco; Department of Epidemiology & Biostatistics, University of California, San Francisco.

Background: Research suggests the need for improvement in the patient-centeredness and comprehensiveness of contraceptive counseling. My Birth Control is a tablet-based decision support tool designed to improve women's experience of contraceptive counseling and to help them select contraceptive methods that are consistent with their values and preferences.

Objective: The objective of this study was to evaluate the effect of My Birth Control on contraceptive continuation, experience of contraceptive care, and decision quality. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.015DOI Listing
February 2019

Looking Through the Lens of a Family Planner to Prioritize Reproductive Health Among Women With Cancer.

J Oncol Pract 2019 Feb 17;15(2):e141-e152. Epub 2018 Dec 17.

1 John H. Stroger, Jr Hospital of Cook County, Chicago, IL.

Purpose:: Prioritization of cancer treatment initiation in women of reproductive age may underscore potential implications on reproductive health. This study describes a family planning quotient (FPQ) and reproductive life index (RepLI) tool designed to help providers to discuss effectively reproductive health with women with cancer.

Methods:: We tailored the FPQ/RepLI tool for patients with cancer after development in the family planning setting and piloted it with 36 oncology patients referred to our family planning clinic. Read More

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http://dx.doi.org/10.1200/JOP.18.00429DOI Listing
February 2019

'Conceivably Neglected' - Are prescribers sufficiently aware of the risks of prescribing sodium valproate to women with mental illness?

Australas Psychiatry 2019 Feb 14:1039856219828175. Epub 2019 Feb 14.

Consultant Psychiatrist and staff specialist, Fellow Royal Australian and New Zealand College of Psychiatrists, Redcliffe-Caboolture Mental Health Service, Metro-North Mental Health Service, Brisbane, QLD, Australia.

Objectives:: To describe prescription of sodium valproate (SV) for bipolar mood disorder to potentially child-bearing women within one public mental health service and describe risks of fetal exposure, and safe prescribing practices among psychiatrists.

Methods:: A 24-month retrospective chart review with descriptive analysis; narrative review of literature and guidelines.

Results:: Review of 383 charts demonstrated prescription of valproate to 20% of 98 women aged 15-45, with little evidence of advice regarding risk and contraception. Read More

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http://dx.doi.org/10.1177/1039856219828175DOI Listing
February 2019

Power relations and negotiations in contraceptive decision-making when husbands oppose family planning: analysis of ethnographic vignette couple data in Southwest Nigeria.

Cult Health Sex 2019 Feb 14:1-13. Epub 2019 Feb 14.

a Department of Social Statistics and Demography and Centre for Global Health, Population, Poverty and Policy , University of Southampton , Southampton , UK.

Contraceptive use in Nigeria has remained low at less than 15% for over two decades. Although husbands' opposition is acknowledged as one of the factors impeding women's contraceptive use, little is known about how wives negotiate when their husbands oppose family planning. We addressed this research gap by conducting thematic analyses of qualitative data from 30 interviews of married couples. Read More

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http://dx.doi.org/10.1080/13691058.2019.1568576DOI Listing
February 2019

Scarcity mindset in reproductive health decision making: a qualitative study from rural Malawi.

Cult Health Sex 2019 Feb 14:1-16. Epub 2019 Feb 14.

b Division of Infectious Disease, College of Public Health , The Ohio State University , Columbus , OH , USA.

Poverty has widespread impacts on health. In dealing with resource scarcity, individuals' thoughts are narrowed to address immediate resource limitations, thus crowding out other information, a phenomenon called the scarcity mindset. To assess for indication of a scarcity mindset in sexual and reproductive decision making in rural Malawi, a setting with extreme resource scarcity, we collected qualitative data in the form of eight focus group discussions and 28 semi-structured, in-depth interviews with women and men of varying ages and marital status. Read More

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https://www.tandfonline.com/doi/full/10.1080/13691058.2018.1
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http://dx.doi.org/10.1080/13691058.2018.1562092DOI Listing
February 2019
1 Read

Complex decisions: correlates of injectable contraceptive discontinuation following HIV-1 seroconversion in an HIV prevention trial.

AIDS Care 2019 Feb 13:1-8. Epub 2019 Feb 13.

b David Geffen School of Medicine , University of California , Los Angeles.

Contraceptive adherence during acute and recent HIV-1 infection is important to maternal and child health given the elevated risk of vertical HIV-1 transmission and additional complications of pregnancy. Injectable contraception (IC) is the most common non-barrier modern contraception method used in sub-Saharan Africa (SSA). Adherence to IC after HIV-1 seroconversion is not well understood. Read More

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https://www.tandfonline.com/doi/full/10.1080/09540121.2019.1
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http://dx.doi.org/10.1080/09540121.2019.1580345DOI Listing
February 2019
2 Reads

Chlamydia trachomatis in women with pelvic inflammatory disease (PID): report from a tertiary center in eastern Nepal.

Trop Doct 2019 Feb 12:49475519826195. Epub 2019 Feb 12.

6 Additional Professor, Department of Microbiology, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Chlamydia trachomatis is an important agent of pelvic inflammatory disease (PID) globally. Laboratory diagnosis, which is vital for early and appropriate treatment, remains a challenge in resource-limited settings. Our study was undertaken to detect C. Read More

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http://dx.doi.org/10.1177/0049475519826195DOI Listing
February 2019

Male hormonal contraception: a safe option?

Expert Rev Endocrinol Metab 2006 Jan;1(1):25-32

b The University of Edinburgh, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

Hormonal male contraception is based on the administration of testosterone alone or more likely with a progestogen. Testosterone has been used for several decades for the treatment of male hypogonadism, with an excellent safety record. Use as part of a contraceptive regimen by healthy people for prolonged periods will necessitate careful re-examination of safety issues. Read More

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http://dx.doi.org/10.1586/17446651.1.1.25DOI Listing
January 2006

Tenofovir gel for prevention of herpes simplex virus type-2 acquisition: findings from the VOICE Trial.

J Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

Magee-Womens Research Institute, Pittsburgh, PA.

Background: Genital infection with herpes simplex virus type-2 (HSV-2) is common, and increases risk of HIV transmission and acquisition. Pericoital use of tenofovir (TFV) gel provided protection from HSV-2 acquisition in the CAPRISA 004 Study.

Methods: We measured estimate of effect of vaginal TFV 1% gel in preventing HSV-2 acquisition among women in VOICE, randomized, double-blind, placebo-controlled trial assessing daily use of oral and vaginal TFV for HIV-1 pre-exposure prophylaxis. Read More

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http://dx.doi.org/10.1093/infdis/jiz045DOI Listing
February 2019

A new approach to assess the capability of health facilities to provide clinical care for sexual violence against women: a pilot study.

Health Policy Plan 2019 Feb 8. Epub 2019 Feb 8.

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.

Several tools have been developed to collect information on health facility preparedness to provide sexual violence response services; however, little guidance exists on how this information can be used to better understand which functions a facility can perform. Our study therefore aims to propose a set of signal functions that provide a framework for monitoring the availability of clinical sexual violence services. To illustrate the potential insights that can be gained from using our proposed signal functions, we used the framework to analyse data from a health facility census conducted in Central Province, Zambia. Read More

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http://dx.doi.org/10.1093/heapol/czy106DOI Listing
February 2019

Fertility Counseling for Adolescents.

Pediatr Ann 2019 Feb;48(2):e86-e91

Fertility awareness, or general knowledge about one's fertility, is low in adolescents and in adult women as well. Misconceptions about reproduction contribute to high rates of unplanned pregnancy in the United States, as well as delayed childbearing and infertility. Alhough primary care providers caring for adolescents have historically focused on contraception and reduction of sexually transmitted infections during their sexual and reproductive health conversations with adolescents and young adult women, fertility awareness counseling would help these women optimize their future fertility and make informed reproductive choices throughout their life. Read More

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http://dx.doi.org/10.3928/19382359-20190117-01DOI Listing
February 2019

Contraceptive Needs of Adolescents with Chronic Illness.

Pediatr Ann 2019 Feb;48(2):e78-e85

Contraception and sexual health form a key part of comprehensive health care for all adolescents, including those who suffer from chronic illness. Multiple studies have shown that adolescents with chronic illness have rates of sexual activity equal to or greater than their healthy counterparts. Primary care pediatricians have the most comprehensive view of the health of their medically complex patients and the benefit of a longstanding relationship. Read More

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http://dx.doi.org/10.3928/19382359-20190121-01DOI Listing
February 2019
1 Read

Birth Control Management for the Primary Care Provider.

Authors:
Rachel S Dawson

Pediatr Ann 2019 Feb;48(2):e51-e55

Contraceptive management is occurring more frequently in the primary care setting. Pediatricians should be familiar with the most common methods of contraception due to the fact that families are comfortable seeking care for their adolescents at the primary care office for these types of concerns. Contraceptive methods are often used for noncontraceptive benefits as well, which makes it even more important to feel comfortable prescribing contraceptives at pediatricians' offices. Read More

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http://dx.doi.org/10.3928/19382359-20190111-01DOI Listing
February 2019

A new analytic tool developed to assess safe use recommendations.

Pharmacoepidemiol Drug Saf 2019 Feb 12. Epub 2019 Feb 12.

Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

Purpose: Develop a flexible analytic tool for the Food and Drug Administration's (FDA's) Sentinel System to assess adherence to safe use recommendations with two capabilities: characterize adherence to patient monitoring recommendations for a drug, and characterize concomitant medication use before, during, and/or after drug therapy.

Methods: We applied the tool in the Sentinel Distributed Database to assess adherence to the labeled recommendation that patients treated with dronedarone undergo electrocardiogram (ECG) testing no less often than every 3 months. Measures of length of treatment, time to first ECG, number of ECGs, and time between ECGs were assessed. Read More

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http://dx.doi.org/10.1002/pds.4724DOI Listing
February 2019

Treatment of Juvenile Myoclonic Epilepsy in Patients of Child-Bearing Potential.

CNS Drugs 2019 Feb 11. Epub 2019 Feb 11.

Epilepsy Unit, Hôpital Gui de Chauliac, 80 Avenue Fliche, 34295, Montpellier Cedex 05, France.

Juvenile myoclonic epilepsy (JME) is both a frequent and a very characteristic epileptic syndrome with female preponderance. Treatment of JME in women of childbearing potential must consider multiple factors such as desire for pregnancy, use of contraception, seizure control and previously used antiepileptic drugs (AEDs). Approximately 85% of cases are well controlled with valproate, which remains the reference AED in JME but is nowadays considered unsafe for the expecting mother and her fetus. Read More

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http://link.springer.com/10.1007/s40263-018-00602-2
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http://dx.doi.org/10.1007/s40263-018-00602-2DOI Listing
February 2019
2 Reads

Rabies on the Indian subcontinent.

Authors:
S A Rahman S Isloor

Rev Sci Tech 2018 Aug;37(2):529-542

The Indian subcontinent comprises Afghanistan, Bangladesh, Bhutan, India, Nepal, the Maldives, Myanmar, Pakistan and Sri Lanka. In all of these countries, except the Maldives, rabies is endemic. An estimated 59,000 people die from rabies each year; 45% of these deaths occur on the Indian subcontinent and approximately 33% take place in India. Read More

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http://dx.doi.org/10.20506/rst.37.2.2821DOI Listing
August 2018
1 Read

Time and motion study of pharmacist prescribing of oral hormonal contraceptives in Oregon community pharmacies.

J Am Pharm Assoc (2003) 2019 Feb 8. Epub 2019 Feb 8.

Objectives: The aim of this time and motion study was to evaluate the procedural time and steps of performing an oral hormonal contraceptive pharmacist prescribing service in an Oregon community pharmacy.

Methods: A standardized patient seeking oral hormonal contraception visited 13 community pharmacies throughout February 2018 in the tri-county Portland, Oregon, metropolitan area for pharmacist-prescribed hormonal contraception services for a total of 26 patient encounters. An observer was present at each encounter to record the time for each step and the total encounter time. Read More

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http://dx.doi.org/10.1016/j.japh.2018.12.015DOI Listing
February 2019

Engaging men in an mHealth approach to support postpartum family planning among couples in Kenya: a qualitative study.

Reprod Health 2019 Feb 11;16(1):17. Epub 2019 Feb 11.

Department of Obstetrics and Gynecology, University of Washington, Harborview Medical Center, 325 Ninth Ave., Boxes 359909, Seattle, WA, 98104, USA.

Background: Involving male partners in family planning (FP) education and counseling may improve FP utilization and help meet couples' reproductive health needs in the postpartum period. We aimed to explore Kenyan men's and women's perspectives on an interactive short message service (SMS) approach to support postpartum FP decision-making, and inform intervention content for a randomized controlled trial (RCT).

Methods: We conducted four focus group discussions (FGD) among men (n = 35) and two among pregnant/postpartum women (n = 15) in western Kenya. Read More

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http://dx.doi.org/10.1186/s12978-019-0669-xDOI Listing
February 2019

Combined hormonal contraceptives for heavy menstrual bleeding.

Cochrane Database Syst Rev 2019 Feb 11;2:CD000154. Epub 2019 Feb 11.

Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland, New Zealand, 1142.

Background: Menorrhagia or heavy menstrual bleeding (HMB) is an excessive blood loss that impairs a woman's quality of life, either physical, emotional, social or material. It is benign and not associated with pregnancy or any other gynaecological or systemic disease. Medical treatments used to reduce excessive menstrual blood loss (MBL) include prostaglandin synthetase inhibitors, antifibrinolytics, oral contraceptive pills, and other hormones. Read More

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http://dx.doi.org/10.1002/14651858.CD000154.pub3DOI Listing
February 2019
3 Reads

Venous Thromboembolism Among Women Initiating Depot Medroxyprogesterone Acetate Immediately Postpartum.

Obstet Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia, and Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, Tennessee.

Objective: To estimate the absolute and relative risk of venous thromboembolism (VTE) among women who initiate depot medroxyprogesterone acetate (DMPA) immediately postpartum compared with those who do not initiate hormonal contraception.

Methods: The IBM MarketScan Commercial Claims and Encounters databases were used to identify delivery hospitalizations among women aged 15-44 years during 2005 through 2014. Diagnosis, procedure, and drug codes were used to identify contraception, VTE, and potential confounding chronic or pregnancy-related conditions. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003135DOI Listing
February 2019

Toward a New Definition of Unmet Need for Contraception.

Stud Fam Plann 2019 Feb 11. Epub 2019 Feb 11.

The current definition of unmet need for contraception assumes that all women who are using a method have a met need. We argue that without taking into account the level of satisfaction with a method, many women are classified as having a met need, when in fact they have an unmet need. They are using a method that does not meet their preferences, either because it causes side effects they find untenable or has other characteristics they do not like. Read More

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http://dx.doi.org/10.1111/sifp.12084DOI Listing
February 2019

The Dynamics of Intimate Partner Violence and the Risk of Pregnancy during the Transition to Adulthood.

Am Sociol Rev 2018 Oct 7;83(5):1020-1047. Epub 2018 Sep 7.

University of Michigan.

Using a reproductive coercion framework, we investigate the role of intimate partner violence (IPV) in pregnancy during the transition to adulthood. We use two types of data from a population-based sample of 867 young women in a Michigan county: a 60-minute survey interview with 2.5 years of weekly follow-up surveys, and semi-structured interviews with a subsample of 40 pregnant women. Read More

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http://dx.doi.org/10.1177/0003122418795856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364682PMC
October 2018

Brain intracrinology of allopregnanolone during pregnancy and hormonal contraception.

Horm Mol Biol Clin Investig 2019 Feb 11. Epub 2019 Feb 11.

Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy.

Allopregnanolone (ALLO) has a crucial role in brain development and remodeling. Reproductive transitions associated with endocrine changes affect synthesis and activity of ALLO with behavioral/affective consequences. Pregnancy is characterized by an increased synthesis of progesterone/ALLO by the placenta, maternal and fetal brains. Read More

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http://dx.doi.org/10.1515/hmbci-2018-0032DOI Listing
February 2019
2 Reads

Society for Maternal-Fetal Medicine (SMFM) Consult Series #48: Immediate postpartum long-acting reversible contraception for women at high-risk for medical complications.

Am J Obstet Gynecol 2019 Feb 7. Epub 2019 Feb 7.

Reproductive planning is important for all women but essential for those with complex health conditions or at high-risk for complications. Pregnancy planning can allow these high-risk women the opportunity to receive preconception counseling, medication adjustment, and risk assessment related to health conditions that directly impact maternal morbidity and mortality risk. Despite the need for pregnancy planning, medically complex women face barriers to contraceptive use, including systemic barriers, such as underinsurance for women at increased risk for complex medical conditions as well as low uptake of effective postpartum contraception. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.011DOI Listing
February 2019
1 Read

Levonorgestrel intrauterine contraceptive systems (13.5 mg and 52 mg) and risk of ectopic pregnancy.

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.

Introduction: The objective was to investigate the Pearl index for ectopic pregnancy in women using levonorgestrel intrauterine system (LNG-IUS) at time of conception.

Material And Methods: This was a sub-study of a hospital based historical cohort including women with an ectopic pregnancy diagnosed in four referral hospitals in Stockholm Sweden between December 2013 and April 2017. Study participants and type of contraception at time of conception were identified through the electronic medical chart system. Read More

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http://dx.doi.org/10.1111/aogs.13564DOI Listing
February 2019
2 Reads

Endocarditis following IUD insertion in a patient with tetralogy of Fallot.

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of Medicine, University of Washington, Seattle, Washington, USA.

The role of antibiotic prophylaxis for prevention of infective endocarditis is unknown. Endocarditis prophylaxis is recommended for certain high-risk individuals prior to dental procedures. To our knowledge, this is the first case reported in the literature of a patient with complex congenital heart disease developing endocarditis in the period immediately following otherwise uncomplicated intrauterine device insertion. Read More

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http://dx.doi.org/10.1136/bcr-2018-227962DOI Listing
February 2019
1 Read

A survey to assess the availability, implementation rate and remuneration of pharmacist-led cognitive services throughout Europe.

Res Social Adm Pharm 2019 Feb 2. Epub 2019 Feb 2.

Instituto Universitário Egas Moniz (IUEM), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Campus Universitário, Quinta da Granja, Monte da Caparica, 2829-511, Caparica, Portugal. Electronic address:

Background: Pharmacist-led cognitive services (PLCS) are increasingly necessary in primary care as a response to patient-centered care. However, the implementation rate and remuneration models of PLCS are either absent or superficially described in the literature.

Objective: The aim of this study is to review the implementation of PLCS in primary care across Europe and explore the associated third-party paid remuneration models. Read More

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http://dx.doi.org/10.1016/j.sapharm.2019.02.002DOI Listing
February 2019
1 Read

Multi-contextual influences on adolescent pregnancy and sexually transmitted infections in the United States.

Soc Sci Med 2019 Jan 29;224:28-36. Epub 2019 Jan 29.

Department of Family Sciences, University of Kentucky, 316 Funkhouser Building, Lexington, KY, 40506, USA. Electronic address:

Rationale: Rates of adolescent pregnancy and sexually transmitted infections (STIs) in the United States remain high. Norms and beliefs about sex and the use of contraception have been identified as potential contributors to these.

Objective: The current study examined multi-contextual links between norms and beliefs about sex and contraception, and adolescent pregnancies and STIs. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.01.024DOI Listing
January 2019
1 Read

Acceptability and Predictors of Uptake of Anti-retroviral Pre-exposure Prophylaxis (PrEP) Among Fishing Communities in Uganda: A Cross-Sectional Discrete Choice Experiment Survey.

AIDS Behav 2019 Feb 8. Epub 2019 Feb 8.

Department of Internal Medicine, Makerere University College of Health Sciences, Kampala, Uganda.

We used a discrete choice experiment to assess the acceptability and potential uptake of HIV pre-exposure prophylaxis (PrEP) among 713 HIV-negative members of fishing communities in Uganda. Participants were asked to choose between oral pill, injection, implant, condoms, vaginal ring (women), and men circumcision. Product attributes were HIV prevention effectiveness, sexually transmitted infection (STI) prevention, contraception, waiting time, and secrecy of use. Read More

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http://dx.doi.org/10.1007/s10461-019-02418-7DOI Listing
February 2019
1 Read

ENU-induced mutant allele of Dnah1, ferf1, causes abnormal sperm behavior and fertilization failure in mice.

Mol Reprod Dev 2019 Feb 8. Epub 2019 Feb 8.

The Jackson Laboratory, Bar Harbor, Maine.

Given attention to both contraception and treatment of infertility, there is a need to identify genes and sequence variants required for mammalian fertility. Recent unbiased mutagenesis strategies have expanded horizons of genetic control of reproduction. Here we show that male mice homozygous for the ethyl-nitroso-urea-induced ferf1 (fertilization failure 1) mutation are infertile, producing apparently normal sperm that does not fertilize oocytes in standard fertilization in vitro fertilization assays. Read More

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http://dx.doi.org/10.1002/mrd.23120DOI Listing
February 2019
1 Read

To be continued: family planning continuation among the urban poor in Senegal, a prospective, longitudinal descriptive study.

Gates Open Res 2018 Dec 3;2:65. Epub 2018 Dec 3.

FHI 360, Durham, NC, USA.

Given the role that continued use of family planning (FP) by current users plays in increasing contraceptive prevalence rates (CPR), this research aims to measure method-specific continuation rates for fixed-site and community-based program interventions and to document reasons for discontinuation.  This research compared discontinuation rates for clients initiating family planning through two types of strategies-services provided at existing health centers that provided regular, ongoing services, and "one-off" outreach services in communities.  Data collectors surveyed consenting clients who were initiating a modern method, or reinitiating after a break of at least six months, and conducted a follow up survey after seven months. Read More

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http://dx.doi.org/10.12688/gatesopenres.12880.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362302PMC
December 2018
3 Reads

An Open-Label, Single-Arm, Efficacy Study of Tranexamic Acid in Adolescents with Heavy Menstrual Bleeding.

J Pediatr Adolesc Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Study Objective: Heavy menstrual bleeding (HMB) occurs in up to 40 % of adolescent girls, significantly impacting their daily activities. Identifying alternative treatment strategies for HMB is particularly important for adolescents who prefer not to take hormonal contraception. Our objective was to determine the ability of tranexamic acid (TA) to increase health-related quality of life and decrease menstrual blood loss (MBL) in adolescents with HMB. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.01.009DOI Listing
February 2019
1 Read

Health Care Provider Attitudes About the Safety of 'Quick Start' Initiation of Long-Acting Reversible Contraception for Adolescents.

J Pediatr Adolesc Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA.

Study Objective: To identify characteristics associated with provider attitudes on the safety of 'Quick Start' initiation of long-acting reversible contraception (LARC) for adolescents.

Study Design, Setting, And Participants: We conducted a cross-sectional survey of providers in public-sector health centers and office-based physicians (n = 2,056) during 2013-2014.

Results: Overall, the prevalence of considering 'Quick Start' initiation of LARC for adolescents as safe was 70. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.01.007DOI Listing
February 2019
1 Read

Medicinal plants used for contraception in South Africa: A review.

J Ethnopharmacol 2019 Feb 4;235:19-27. Epub 2019 Feb 4.

Indigenous Knowledge Systems (IKS) Centre, Faculty of Natural and Agricultural Sciences, North West University, Private Mail Bag X2046, Mmabatho 2790, North West Province, South Africa. Electronic address:

ETHNOPHARMACOLOGICAL RELEVANCE: The indigenous people of South Africa, such as the Khoisan, Zulu, and Ndebele, have used medicinal plants for contraception. One of the reasons for using contraception among indigenous communities is for child spacing.

Aim Of The Study: The study aims to review medicinal plants used for contraception in South Africa as potential sources for the discovery and development of safe male and female hormonal contraceptives. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183238
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http://dx.doi.org/10.1016/j.jep.2019.02.002DOI Listing
February 2019
6 Reads

Effect of cost on early removal of contraceptive implants: a prospective cohort study.

Eur J Contracept Reprod Health Care 2019 Feb 7:1-6. Epub 2019 Feb 7.

e Hospital del Mar Institute of Medical Research (IMIM) , Barcelona , Spain.

Objectives: To evaluate the effect of the cost of subdermal etonogestrel implant (SEI) on the continuation rate one year after insertion, and to assess the reasons given by users to remove the implant before the expiration date.

Methods: Prospective cohort study conducted among 265 women who chose the SEI as a contraceptive method in a sexual and reproductive health center in the eastern region of Spain, between October/2012 and October/2017. The sample was divided into two cohorts depending on the cost of the implant for the user (free-of-charge or requiring partial payment). Read More

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http://dx.doi.org/10.1080/13625187.2018.1564817DOI Listing
February 2019
1 Read

Pregnancy and early motherhood among adolescents in five East African countries: a multi-level analysis of risk and protective factors.

BMC Pregnancy Childbirth 2019 Feb 6;19(1):59. Epub 2019 Feb 6.

African Population and Health Research Centre, APHRC Campus, Manga Close, P.O. Box 10787-00100, Nairobi, Kenya.

Background: Adolescent pregnancy remains a major challenge in both developed and developing countries. Early and unintended pregnancies among adolescents are associated with several adverse health, educational, social and economic outcomes. The aim of this study was to identify the contextual factors that influence adolescent pregnancy and early motherhood in five East African countries. Read More

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http://dx.doi.org/10.1186/s12884-019-2204-zDOI Listing
February 2019
1 Read

Female sex workers in Kigali, Rwanda: a key population at risk of HIV, sexually transmitted infections, and unplanned pregnancy.

Int J STD AIDS 2019 Feb 6:956462418817050. Epub 2019 Feb 6.

1 Projet San Francisco, Rwanda Zambia HIV Research Group, Kigali, Rwanda.

Female sex workers (FSWs) were recruited from known hotspots in Kigali, Rwanda, and offered free, anonymous human immunodeficiency virus (HIV) counseling and testing, diagnosis and treatment of sexually transmitted infections (STIs) and long-acting reversible contraception (LARC). From September 2012 to March 2015, 1168 FSWs sought services, including 587 (50%) who were HIV-positive. More than 90% had previously tested for HIV, and 26% who reported previously testing negative had seroconverted. Read More

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http://dx.doi.org/10.1177/0956462418817050DOI Listing
February 2019
1 Read

Factors associated with induced abortion over time: secondary data analysis of five waves of the Australian Longitudinal Study on Women's Health.

Aust N Z J Public Health 2019 Feb 6. Epub 2019 Feb 6.

Department of Obstetrics and Gynaecology, Monash Health, Victoria.

Objective: A trend analysis of associations with induced abortion.

Methods: Secondary analysis of the 1973/78 cohort of the Australian Longitudinal Study of Women's Health of women responding to two or more consecutive surveys out of five (N=9,042), using generalised estimating equations.

Results: New abortions dropped from 7% to 2% at surveys 4 and 5. Read More

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http://dx.doi.org/10.1111/1753-6405.12874DOI Listing
February 2019
1 Read

Biocompatible polyvinyl alcohol and RISUG® blend polymeric films with spermicidal potential.

Biomed Mater 2019 Feb 6. Epub 2019 Feb 6.

School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, INDIA.

Majority of the commercially available vaginal contraceptives encompasses cervicovaginal membrane disrupting detergent molecules as pharmacologically active ingredients. Development of a tissue-compatible vaginal contraceptive agent is necessary to circumvent the existing demand for female contraception in the reproductive healthcare sector. With this objective, the present study delineates the use of RISUG<sup>®</sup> based non-hormonal female contraceptive films. Read More

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http://dx.doi.org/10.1088/1748-605X/ab04e1DOI Listing
February 2019
3 Reads