119,952 results match your criteria Continuing Education in Anaesthesia Critical Care & Pain [Journal]


Water drop-surface interactions as the basis for the design of anti-fogging surfaces: Theory, practice, and applications trends.

Adv Colloid Interface Sci 2018 Nov 24;263:68-94. Epub 2018 Nov 24.

Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de Génie des Mines, de la Métallurgie et des Matériaux, Université Laval, 1065 Avenue de la médecine, Québec G1V 0A6, Canada; Centre de Recherche du Centre Hospitalier Universitaire de Québec, Hôpital St-François d'Assise, 10 rue de l'Espinay, Québec G1L 3L5, Canada. Electronic address:

Glass- and polymer-based materials have become essential in the fabrication of a multitude of elements, including eyeglasses, automobile windshields, bathroom mirrors, greenhouses, and food packages, which unfortunately mist up under typical operating conditions. Far from being an innocuous phenomenon, the formation of minute water drops on the surface is detrimental to their optical properties (e.g. Read More

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November 2018
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Supportive Care Network: Evaluation of Its Impact on the Performance of a Urology Department.

Acta Med Port 2018 Nov 30;31(11):656-660. Epub 2018 Nov 30.

Urology and Renal Transplantation Department. Coimbra University Hospital Center. Coimbra. Portugal.

Introduction: Hospitals are dealing with patients who may have clinical discharge but cannot return to their home due to non-medical issues.

Material And Methods: Cross-sectional analysis of all the cases referred to the Integrated Care Network during the year 2016. Evaluation of waiting times, typology, reason for referral and clinical parameters. Read More

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November 2018
1 Read

Insight into the perioperative management of direct oral anticoagulants: concerns and considerations.

Expert Opin Pharmacother 2018 Dec 6:1-8. Epub 2018 Dec 6.

d Division of Cardiology, Department of Medicine and Therapeutics , The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong , China.

Introduction: Direct oral anticoagulants (DOACs) have gained momentum in recent years in patients requiring anticoagulation for the prevention and management of venous thromboembolism and thromboembolic events caused by atrial fibrillation. The use of these agents involves potential bleeding complications, particularly during invasive procedures. With increasing use of DOACs, adequate knowledge regarding the perioperative management of patients on DOACs has become indispensable. Read More

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December 2018

The Development of a Core Syllabus for Teaching Musculoskeletal Anatomy of the Vertebral Column and Limbs to Medical Students.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Introduction: The study of human anatomy is fundamental to medical education globally. Knowledge of musculoskeletal anatomy is essential for safe and effective clinical practice, yet this topic often receives insufficient medical programme time and perceptions differ regarding which knowledge is core. Given the lack of syllabuses specific to musculoskeletal anatomy, this paper aims to provide a detailed syllabus for the vertebral column and limbs relevant to medical students. Read More

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December 2018

Continuing Professional Development.

Authors:

J Med Imaging Radiat Oncol 2018 Dec;62(6):869-870

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December 2018

The antibiotic action of methylarsenite is an emergent property of microbial communities.

Mol Microbiol 2018 Nov 22. Epub 2018 Nov 22.

Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, 33199, USA.

Arsenic is the most ubiquitous environmental toxin. Here, we demonstrate that bacteria have evolved the ability to use arsenic to gain a competitive advantage over other bacteria at least twice. Microbes generate toxic methylarsenite (MAs(III)) by methylation of arsenite (As(III)) or reduction of methylarsenate (MAs(V)). Read More

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November 2018

Continuing Medical Education Program in Transfusion.

Authors:

Transfusion 2018 Dec;58(12):2825

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December 2018
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Should We Always Use Antibiotics after Urodynamic Studies in High-Risk Patients?

Biomed Res Int 2018 5;2018:1607425. Epub 2018 Nov 5.

2nd Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

Aim: The aim of this observational study was to evaluate the effectiveness of a phytotherapic drug (Canephron N) in preventing urinary tract infection (UTI) in high-risk women undergoing urodynamic studies (UDS).

Methods: The study protocol was approved by the local institutional ethical committee. Adult women with at least one risk factor for acquiring UTI (defined as: age over 70, elevated postvoid residual urine>100 ml, recurrent UTI, pelvic organ prolapse (POP) ≥II in POP-Q scale, and neurogenic bladder) had received after UDS either a single oral dose of fosfomycin trometamol (FT) (3 grams) or a phytodrug containing centaury herb, lovage root, and rosemary leaves (5 ml taken orally three times daily for one week). Read More

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November 2018
2 Reads

The National Glycohemoglobin Standardization Program: Over 20 Years of Improving Hemoglobin A Measurement.

Clin Chem 2018 Dec 5. Epub 2018 Dec 5.

Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD.

Background: Measurement of hemoglobin A1c (HbA) in the blood is integral to and essential for the treatment of patients with diabetes mellitus. HbA reflects the mean blood glucose concentration over the preceding 8 to 12 weeks. Although the clinical value of HbA was initially limited by large differences in results among various methods, the investment of considerable effort to implement standardization has brought about a marked improvement in analysis. Read More

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December 2018

Prognostic accuracy of different disseminated intravascular coagulation criteria in critically ill adult patients: a protocol for a systematic review and meta-analysis.

BMJ Open 2018 Dec 4;8(12):e024878. Epub 2018 Dec 4.

Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan.

Introduction: Disseminated intravascular coagulation (DIC) is a common and serious condition that can lead to poor outcomes in critically ill patients. To make a correct diagnosis and improve the outcome of patients with DIC, several organisations have put forward DIC scoring systems. However, which criteria is the best to use for diagnosing DIC remains a continuing controversy even though many studies have been conducted to validate the diagnostic accuracy of each DIC scoring system. Read More

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December 2018
2 Reads

Risk of Post-polypectomy Bleeding With Uninterrupted Clopidogrel Therapy in an Industry-independent, Double-blind, Randomized Trial.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine & Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China (SAR); State Key Laboratory of Digestive Disease, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China (SAR).

Background & Aims: Guidelines recommend withholding clopidogrel 7 days before polypectomy to reduce bleeding risk, but these were written based on limited evidence. We investigated whether uninterrupted clopidogrel therapy increases the risk of delayed post-polypectomy bleeding in patients undergoing colonoscopy.

Methods: We identified patients receiving clopidogrel for cardiovascular disease undergoing elective colonoscopies in Hong Kong, from 28 February 2012 through 11 April 2018. Read More

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October 2018
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Diagnostic accuracy of molecular methods for detecting markers of antimalarial drug resistance in clinical samples of Plasmodium falciparum: protocol for an update to a systematic review and meta-analysis.

Syst Rev 2018 Dec 5;7(1):221. Epub 2018 Dec 5.

Green Templeton College, University of Oxford, Oxford, UK.

Background: Each year, infection with Plasmodium causes millions of clinical cases of malaria and hundreds of thousands of deaths. Resistance to different antimalarial medications continues to develop and spread, threatening effective prophylaxis and treatment. Surveillance of resistance is required to inform health policy and preserve effective antimalarial drugs; molecular methods can be used to surveil likely parasite resistances. Read More

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December 2018
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The importance of time in therapeutic range in switching from vitamin K antagonist to non-vitamin K antagonist oral anticoagulants in atrial fibrillation.

Europace 2018 Dec 1. Epub 2018 Dec 1.

Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 3, København Ø, Denmark.

Aims: Patients with non-valvular atrial fibrillation (NVAF) receiving vitamin K antagonists (VKAs) with time in therapeutic international normalized ratio (INR) range (TTR) <70%, despite good adherence, are by guidelines recommended to switch to non-VKA oral anticoagulants (NOACs). The aim was to assess if patients are switched from VKA to NOAC when TTR is <70% in a real-world setting.

Methods And Results: Non-valvular atrial fibrillation patients receiving VKA (1 January 2010 to 31 December 2012) were identified in nationwide registries. Read More

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December 2018

Do dGEMRIC and T2 Imaging Correlate With Histologic Cartilage Degeneration in an Experimental Ovine FAI Model?

Clin Orthop Relat Res 2018 Nov 29. Epub 2018 Nov 29.

F. Schmaranzer, E. F. Liechti, M. Tannast, Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland L. Arendt, K. Nuss, B. von Rechenberg, M. Tannast, Musculoskeletal Research Unit (MSRU), Equine Hospital, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland P. R. Kircher, Department of Small Animals, Division of Diagnostic Imaging, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.

Background: Biochemical MRI of hip cartilage such as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 mapping is increasingly used to judge cartilage quality in the assessment of femoroacetabular impingement (FAI). The current evidence is sparse about which of these techniques yields a stronger correlation with histologic cartilage degeneration because of the difficulty in validating biochemical MRI techniques against histology in the clinical setting. Recently, an experimental ovine FAI model was established that induces chondrolabral damage and offers a validated platform to address these limitations. Read More

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November 2018
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Developing an Innovative Statewide Infrastructure and Model for Delivering Continuing Interprofessional Education: The North Carolina AHEC Initiative.

J Contin Educ Health Prof 2018 Fall;38(4):282-292

Dr. Russet R. Rogers: Vice-President, Regional Education and Information Services, Southern Regional AHEC, Fayetteville, NC. Dr. John A. Owen: Associate Director, Center for ASPIRE, Assistant Professor, School of Nursing, University of Virginia, Charlottesville, VA. Dr. Donna M. Lake: Associate Professor, School of Nursing, East Carolina University, Greenville, NC. Dr. Carol Fowler Durham: Professor and Director EISLE, School of Nursing, University of North Carolina, Chapel Hill, NC. Ms. Tina G. Latham: Assistant Director, Regional Education, Greensboro AHEC, Greensboro, NC. Dr. Gwen Sherwood: Professor and Associate Dean for Global Initiatives, School of Nursing, University of North Carolina, Chapel Hill, NC. Mr. Christopher S. Golding: Deputy Executive Officer, Practice and Education, North Carolina Nurses Association, Raleigh, NC.

Introduction: North Carolina AHEC (NC AHEC) leadership recognized that continuing interprofessional education (CIPE) is vital for improving patient care and outcomes. Rather than train and educate in professional silos, interprofessional education presented an opportunity to reframe continuing education (CE) to improve the integration of care delivery and outcomes.

Methods: In April 2014, two regional AHECs collaborated to design a statewide initiative for AHEC CE leaders, CE professionals, and CE faculty to learn about integrating interprofessional education into CE planning and implementation. Read More

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December 2018

Quality of life after breast reconstruction-the BRIOS study.

Lancet Oncol 2018 Nov 1;19(11):e579. Epub 2018 Nov 1.

Kellogg College, Department of Continuing Education, University of Oxford, Oxford, UK; Department of Surgery and Cancer, Imperial College London, London, UK.

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November 2018

Amisulpride for very late-onset schizophrenia-like psychosis: the ATLAS three-arm RCT.

Health Technol Assess 2018 Nov;22(67):1-62

Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.

Background: Very late-onset (aged ≥ 60 years) schizophrenia-like psychosis (VLOSLP) occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy or risks of antipsychotic treatment. Most patients are not prescribed treatment.

Objectives: The study investigated whether or not low-dose amisulpride is superior to placebo in reducing psychosis symptoms over 12 weeks and if any benefit is maintained by continuing treatment thereafter. Read More

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November 2018
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What should be in hospital doctors' continuing professional development?

J R Soc Med 2018 Dec 3:141076818808427. Epub 2018 Dec 3.

2 Dean, Royal Society of Medicine, London W1G 0AE, UK.

Objective: To ask those most affected by continuing professional development for senior doctors - patients, other professional groups and doctors themselves - what it needs to encompass.

Design: The nominal group technique.

Participants: Six groups of between seven and nine members (n = 49). Read More

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December 2018
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An evidence-based program for rural surgical and obstetrical networks.

Rural Remote Health 2018 Dec 4;18(4):4921. Epub 2018 Dec 4.

Department of Family Practice, University of British Columbia, 5950 University Boulevard, Vancouver BC, V6T 1Z3, Canada

Context: Over the past 25 years, the attrition of small volume rural surgery programs across Western Canada has been significant and sustained. The 'Joint position paper on rural surgery and operative delivery' (JPP) offers a consensus policy framework for the sustainability of rural surgical programs by nesting them within larger regional programs. The many recommendations in the JPP coalesce around the recognition that surgical care should be provided as close to home as possible. Read More

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December 2018

Aging out or continuing on? Exploring strategies to prepare marginalized youth for a transition to recovery in adulthood.

Psychiatr Rehabil J 2018 Dec;41(4):258-265

The Jewish Board of Family and Children's Services.

Objective: This study aimed to improve our understanding of how to best assist marginalized youth during their transition to adulthood, and how to provide them services that help them achieve independence within existing public systems of care.

Method: Using purposive sampling methods, 17 direct service providers and supervisors of a large behavioral health organization participated in individual interviews and focus groups.

Results: A team of analysts identified eight primary themes: (a) the primacy of consistent and caring relationships with adults; (b) working with youth and family concurrently; (c) the complicated dance of autonomy and independence; (d) engagement of alumni and peers in service delivery; (e) transition navigator: an active not passive approach to becoming an adult; (f) youth as the drivers of treatment and recovery; (g) provider training and resources to address the unique needs of transition-age youth; and (h) broadening the definition of treatment. Read More

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December 2018

Effects of a programme to advance scholarly writing.

Clin Teach 2018 Dec 3. Epub 2018 Dec 3.

School of Medicine, University of California, California, San Diego, USA.

Background: Scholarly writing, although central to the completion of doctoral studies, is often not supported by systematic teaching/learning approaches that specifically help students to convey scholarship through writing. The purpose of this project was to promote writing as an essential component of scholarship, provide opportunities for students to develop a self-awareness of confidence in writing and challenges to writing, and to improve writing competence.

Methods: An innovative set of peer-supported interventions was embedded within a core foundational course in a Doctor of Nursing Practice (DNP) programme during the first academic semester as part of a continuing quality improvement process to improve DNP student writing. Read More

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December 2018

Negative interactions among nurses. An explorative study on lateral violence and bullying in nursing work settings.

J Nurs Manag 2018 Dec 1. Epub 2018 Dec 1.

Department of Health Sciences, University of Florence, Florence, Italy.

Background: Lateral violence and bullying affect nurses' professional and health status. Worldwide prevalence ranges from 1 to 87%.

Aim: To investigate prevalence and risk factors of lateral violence and bullying among Italian nurse peers in different work settings, inside and outside hospitals. Read More

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December 2018

Aviation Noise and Cardiovascular Health in the United States: a Review of the Evidence and Recommendations for Research Direction.

Curr Epidemiol Rep 2018 Jun 26;5(2):140-152. Epub 2018 Apr 26.

Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.

Purpose Of The Review: In the USA, there is mounting pressure on aviation operators and regulators to address concerns about community impacts of aircraft noise given increasing evidence of adverse health impacts, continuing community complaints, availability of cost-effective programs to reduce exposures to aircraft noise, and more stringent international policies. In the USA, regulation of civil aviation noise is the responsibility of the Federal Aviation Administration (FAA), which requires a "significant body of scientific support," particularly applicable to the USA, to inform health-based policy and regulatory decisions. However, there have been very few studies investigating the relationship between noise and health in the USA and limited studies across the globe characterizing the effects of aviation noise specifically on cardiovascular health. Read More

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Teaching foundational attitudes and knowledge for psychological practice with older adults: Commentary on.

Clin Psychol (New York) 2018 Jun 5;25(2). Epub 2018 May 5.

VA New England Geriatrics Research Education and Clinical Center (GRECC), Harvard Medical School, Boston, Massachusetts.

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Immobilization of glycans on solid surfaces for application in glycomics.

J Carbohydr Chem 2018 27;37(4):225-249. Epub 2018 Apr 27.

Department of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri, USA.

Carbohydrates are an important class of biomolecules which are involved in a multitude of cellular functions. In the field of glycomics, the structure and function of various carbohydrates, oligosaccharides, glycans and their conjugates are constantly under investigation. In the continuing quest to understand the roles of carbohydrates in their interactions with proteins, immunogens, and other cell-surface carbohydrates, scientists have developed methods for observing the effects of specific saccharide sequences on various cellular components. Read More

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Service Engagement and Retention: Lessons from the Early Childhood Connections Program.

Child Youth Serv Rev 2018 May 19;88:114-127. Epub 2018 Feb 19.

Washington University in St. Louis.

The high attrition rates found in studies of early childhood home visitation create barriers to measuring the effectiveness of such programs. Most studies examine attrition at program completion. This practice may mask important differences in characteristics between families that end participation at various time points. Read More

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Cost-effective Tapering Algorithm in Rheumatoid Arthritis Patients: Combination of Multibiomarker Disease Activity Score and Autoantibody Status.

J Rheumatol 2018 Dec 1. Epub 2018 Dec 1.

From the Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany; St. Vincent Hospital, Vinforce Study Group, Medical University of Vienna, Vienna, Austria; Institutio de Rheumatologia, São Paolo, Brazil; University of Würzburg, Internal Medicine 2, Würzburg; University Medical Center Freiburg, Rheumatology and Clinical Immunology, Freiburg; Rheumatology Clinical Practice Erlangen, Erlangen; Rheumatology Practice and Department of Internal Medicine 2, Clinic Burghausen, Burghausen; Asklepios Medical Center, Department of Rheumatology and clinical Immunology, Bad Abbach; Rheumatology Practice Bamberg, Bamberg; Rheumatology Practice Bayreuth, Bayreuth; University of Heidelberg, Medicine 5, Heidelberg; Rheumatology Practice Nuremberg, Nuremberg; Schlosspark Klinik, Internal Medicine/Rheumatology, Berlin; University of Tübingen, Centre for Interdisciplinary Clinical Immunology, Tübingen; Praxiszentrum St. Bonifatius, Munich, Germany. M. Hagen, BSc, CandMed, FAU, Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen; M. Englbrecht, PhD, FAU, Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen; J. Haschka, MD, St. Vincent Hospital, Vinforce Study Group, Medical University of Vienna; M. Reiser, FAU, Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen; A. Kleyer, MD, FAU, Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen; A. Hueber, MD, FAU, Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen; B. Manger, MD, FAU, Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen; C. Figueiredo, MD, Institutio de Rheumatologia; J. Fogagnolo Cobra, MD, Institutio de Rheumatologia; H.P. Tony, MD, University of Würzburg, Internal Medicine 2; S. Finzel, MD, University Medical Center Freiburg, Rheumatology and Clinical Immunology; S. Kleinert, MD, Rheumatology Clinical Practice Erlangen; J. Wendler, MD, Rheumatology Clinical Practice Erlangen; F. Schuch, MD, Rheumatology Clinical Practice Erlangen; M. Ronneberger, MD, Rheumatology Clinical Practice Erlangen; M. Feuchtenberger, MD, Rheumatology Practice and Department of Internal Medicine 2, Clinic Burghausen; M. Fleck, MD, Asklepios Medical Center, Department of Rheumatology and clinical Immunology; K. Manger, MD, Rheumatology Practice Bamberg; W. Ochs, MD, Rheumatology Practice Bayreuth; H.M. Lorenz, MD, University of Heidelberg, Medicine 5; H. Nüsslein, MD, Rheumatology Practice Nuremberg; R. Alten, MD, Schlosspark Klinik, Internal Medicine/Rheumatology; J. Henes, MD, University of Tübingen, Centre for Interdisciplinary Clinical Immunology; K. Krüger, MD, Praxiszentrum St. Bonifatius; G. Schett, MD, FAU, Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen; J. Rech, MD, FAU, Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen. Address correspondence to Dr. J. Rech, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Ulmenweg 18, 91054 Erlangen, Germany. E-mail: Accepted for publication September 7, 2018.

Objective: To analyze the effect of a risk-stratified disease-modifying antirheumatic drug (DMARD)-tapering algorithm based on multibiomarker disease activity (MBDA) score and anticitrullinated protein antibodies (ACPA) on direct treatment costs for patients with rheumatoid arthritis (RA) in sustained remission.

Methods: The study was a posthoc retrospective analysis of direct treatment costs for 146 patients with RA in sustained remission tapering and stopping DMARD treatment, in the prospective randomized RETRO study. MBDA scores and ACPA status were determined in baseline samples of patients continuing DMARD (arm 1), tapering their dose by 50% (arm 2), or stopping after tapering (arm 3). Read More

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December 2018
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U.S. Maxillofacial Prosthetics Programs: Fellows' and Directors' Perspectives.

J Dent Educ 2018 Dec;82(12):1335-1342

James L. Sheets, DDS, FACP, is Associate Professor, Department of Prosthodontics, School of Dentistry, Creighton University; Daniel J. Pinkston, DDS, is a former Resident, Advanced Education in Prosthodontics, College of Dentistry, University of Illinois at Chicago; Judy Chia-Chun Yuan, DDS, MS, FACP, is Associate Professor and Predoctoral Implant Program Director, Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago; Cortino Sukotjo, DDS, MMSc, PhD, FACP, is Associate Professor, Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago; and Alvin G. Wee, BDS, DDS, MS, MPH, PhD, is a Maxillofacial Prosthodontist, Veterans Affairs Nebraska Western Iowa Health Care System, Omaha, Nebraska and Associate Professor, Department of Prosthodontics, School of Dentistry, Creighton University.

Maxillofacial prosthetics (MFP) programs in the U.S. select only a limited number of applicants for fellowship positions. Read More

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December 2018

TTP: long-term outcomes following recovery.

Authors:
James N George

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):548-552

Hematology-Oncology Section, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Although risk for relapse may be the greatest concern following recovery from acquired, autoimmune thrombotic thrombocytopenic purpura (TTP), there are multiple other major health issues that must be recognized and appropriately addressed. Depression may be the most common disorder following recovery from TTP and may be the most important issue for the patient's quality of life. Severe or moderate depression has occurred in 44% of Oklahoma Registry patients. Read More

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November 2018

Optimizing quality care for the oral vitamin K antagonists (VKAs).

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):332-338

Cardiology Clinic, Thrombosis Centre, University of Padua, Padua, Italy.

Vitamin K antagonists (VKAs) have been the only oral anticoagulants for decades. The management of anticoagulant therapy with VKA is challenging because of the intricate pharmacological properties of these agents. The success of VKA therapy depends on the quality of treatment that is ensured through continuing comprehensive communication and education. Read More

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November 2018

Conditional Knockout of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake.

J Neurosci 2018 Nov 30. Epub 2018 Nov 30.

Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, Utah

Astrocyte expression of metabotropic glutamate receptor 5 (mGluR5) is consistently observed in resected tissue from patients with epilepsy and is equally prevalent in animal models of epilepsy. However, little is known about the functional signaling properties or downstream consequences of astrocyte mGluR5 activation during epilepsy development. In the rodent brain, astrocyte mGluR5 expression is developmentally regulated and confined in expression/function to the first weeks of life, with similar observations made in human control tissue. Read More

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November 2018
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Thermoregulation and markers of muscle breakdown in malignant hyperthermia susceptible volunteers during an acute heat tolerance test.

J Sci Med Sport 2018 Nov 23. Epub 2018 Nov 23.

Survival and Thermal Medicine Department, Institute of Naval Medicine, UK.

Objectives: The study was undertaken to compare the thermal and biochemical responses to a heat tolerance test (HTT) of malignant hyperthermia (MH) susceptible individuals, volunteers who have suffered heat illness (HI) and control volunteers.

Methods: Three groups of male volunteers (n=6 in each group) were recruited to the study: MHS - civilian volunteers previously diagnosed as MH susceptible; EHI - military volunteers with a history of exertional HI; CON - military volunteers with no history of HI or MH. For the HTT, volunteers walked on a treadmill at 60% maximal oxygen uptake in a hot environment. Read More

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November 2018
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Quality-of-life outcomes of a weight management program for adolescents based on motivational interviewing.

Patient Educ Couns 2018 Nov 22. Epub 2018 Nov 22.

Faculty of Psychology and Educational Sciences, University of Porto, Rua Alfredo Allen 535, Porto, Portugal. Electronic address:

Objective: To compare motivational interviewing (MI) with conventional care regarding the health-related quality-of-life (HRQoL) of adolescents with overweight/obesity.

Methods: RCT with parallel design, involving two groups: intervention group (MI group [MIG]) and control group (conventional intervention group [CIG]). The intervention included three 30-minute interviews 3 months apart. Read More

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November 2018

Evaluating the concurrent validity of body mass index (BMI) in the identification of malnutrition in older hospital inpatients.

Clin Nutr 2018 Nov 10. Epub 2018 Nov 10.

Nutrition and Dietetics Department, The Prince Charles Hospital, Brisbane, Chermside, Queensland 4032, Australia; School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia. Electronic address:

Background: Nutrition screening and assessment tools often include body mass index (BMI) as a component in identifying malnutrition risk. However, rising obesity levels will impact on the relevancy and applicability of BMI cut-off points which may require re-evaluation. This study aimed to explore the relationship between commonly applied BMI cut-offs and diagnosed malnutrition. Read More

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November 2018

Medline indexing success and future directions for Irish Journal of Psychological Medicine.

Authors:
John Lyne

Ir J Psychol Med 2018 Dec;35(4):273-274

Royal College of Surgeons in Ireland and North Dublin Mental Health Services,Ashlin Centre,Beaumont Road,Dublin 9,Ireland.

Irish Journal of Psychological Medicine (IJPM) was recently accepted for indexing on Medline. This reflects the high scientific quality of articles published in the journal and highlights the excellent work by publishers, authors, reviewers and the journal editorial board who have contributed to the journal's development over many years. IJPM remains committed to further progression through constant innovation and maintaining the excellent standard of publishing to date. Read More

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December 2018

Identification of novel small molecule inhibitors against the NS3/4A protease of hepatitis C virus genotype 4a.

Curr Pharm Des 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo. Egypt.

Background Hepatitis C virus (HCV) infection poses a considerable threat to the public health. The current standard of care treatment with pegylated interferon-alpha in combination with ribavirin (PEG-IFN-α+RBV) is associated with significant side effects, poorly tolerated, and provides limited efficacy. The development of direct-acting antiviral agents (DAAs) targeting key viral enzymes essential for viral replication represents a significant milestone in the treatment of chronic HCV infection. Read More

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December 2018

Are Health-Care Providers Well Prepared in Providing Optimal End-of-Life Care to Critically Ill Patients? A Cross-Sectional Study at a Tertiary Care Hospital in the United States.

J Intensive Care Med 2018 Dec 3:885066618811794. Epub 2018 Dec 3.

4 Department of Pulmonary and Critical Care Medicine, Northwell Health Staten Island University Hospital, Staten Island, NY, USA.

It is important for health-care providers to be comfortable in providing end-of-life (EOL) care to critically ill patients and realizing when continuing aggressive measures would be futile. Therefore, there is a need to understand health-care providers' self-perceived skills and barriers to providing optimum EOL care. A total of 660 health-care providers from medicine and surgery departments were asked via e-mail to complete an anonymous survey assessing their self-reported EOL care competencies, of which 238 responses were received. Read More

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December 2018

Does continuing professional development make good doctors?

Intern Med J 2018 Dec;48(12):1553-1554

Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.

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December 2018

Fresh transfer of Day 5 slow-growing embryos versus deferred transfer of vitrified, fully expanded Day 6 blastocysts: which is the optimal approach?

Hum Reprod 2018 Dec 4. Epub 2018 Dec 4.

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology. McGill University Health Care Center, 1001 Decarie Blvd, Montreal, Canada.

Study Question: In IVF cycles in which the entire embryo cohort is slow growing, is it optimal to perform fresh transfer in Day 5 or to extend the culture and transfer in subsequent vitrified-warmed cycles?

Summary Answer: The outcomes depend on the degree of embryo development on Day 5.

What Is Known Already: Slow-growing blastocysts have lower implantation potential when transferred in fresh cycles. It has been suggested that embryo-endometrial asynchrony could explain this finding. Read More

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December 2018

[Key arenas in the struggle for abortion rights in Argentina].

Authors:
Mónica Tarducci

Salud Colect 2018 Jul-Sep;14(3):425-432

Doctora en Antropología Social. Directora, Instituto Interdisciplinario de Estudios de Género, Facultad de Filosofía y Letras, Universidad de Buenos Aires. Ciudad de Buenos Aires, Argentina.

The huge mobilization seen in 2018 around the right to legal abortion in Argentina is the crowning point of a struggle that has been going on for many years, and that like any emancipatory movement has had different milestones as well as victories and setbacks, but that has never been abandoned. This article considers some of the actions that have marked that history, beginning with the pioneering women of the seventies, and continuing with the Commission for the Right to Abortion [Comisión por el Derecho al Aborto] after the restoration of democracy in the 1980s, followed by the experiences of Women Coming Together for the Right to Choose [Mujeres Autoconvocacadas por el Derecho a Decidir], the Assembly for the Right to Abortion [Asamblea por el Derecho al Aborto], and the present Campaign for the Right to Legal, Safe and Free Abortion [Campaña por el Derecho al Aborto Legal, Seguro y Gratuito], which succeeded in getting the bill that decriminalizes and legalizes abortion treated in the National Congress. Read More

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June 2018
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Sarcopenia and its association with changes in socioeconomic, behavioral, and health factors: the EpiFloripa Elderly Study.

Cad Saude Publica 2018 Nov 29;34(12):e00164917. Epub 2018 Nov 29.

Universidade Federal de Santa Catarina, Florianópolis, Brasil.

This study aimed to verify the prevalence of sarcopenia and its association with changes in socioeconomic, behavioral, and health factors in the elderly. The longitudinal population-based study included 598 elderly (≥ 60 years) in Florianópolis, Santa Catarina State, in the South of Brazil. Sarcopenia was defined on the basis of appendicular skeletal mass index (ASMI) according to gender (ASMI < 7. Read More

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November 2018
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How do pregnant and lactating women, and young children, experience religious food restriction at the community level? A qualitative study of fasting traditions and feeding behaviors in four regions of Ethiopia.

PLoS One 2018 5;13(12):e0208408. Epub 2018 Dec 5.

Department of Nutrition and Dietetics, Mekelle University, College of Health Sciences, Mekelle, Ethiopia.

Maternal and child feeding behaviors are often rooted in family and sociocultural context, making these an important point of inquiry for improving nutrition and health over the life course. The present study explored the practice of fasting during religious periods in relation to eating patterns of pregnant and lactating women and young children in four regions of Ethiopia, a nation which has experienced rapid economic growth and marked improvement in health and nutrition outcomes over the last two decades. Qualitative data collection and analysis at community level illustrated conflicting areas of understanding and practice related to diets of children and pregnant and lactating women during fasting times, potentially leading to gaps in nutrition. Read More

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December 2018

Association of Surgical Risk With Exogenous Hormone Use in Transgender Patients: A Systematic Review.

JAMA Surg 2018 Dec 5. Epub 2018 Dec 5.

Center for Gender Surgery, Boston Children's Hospital, Boston, Massachusetts.

Importance: A growing number of transgender patients are receiving gender-affirming hormone treatments. It is unclear whether the evidence supports the current practice of routinely discontinuing these hormones prior to surgery.

Objective: To determine how medications used in cross-sex hormone treatment (CSHT) affect perioperative risk. Read More

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December 2018
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Assessing the relation of the coded nursing care and nursing intensity data: Towards the exploitation of clinical data for administrative use and the design of nursing workload.

Health Informatics J 2018 Dec 5:1460458218813613. Epub 2018 Dec 5.

University of Eastern Finland, Finland.

Patient-care data from the electronic health record systems are increasingly in demand for re-use in administration and resource planning. Nursing documentation with coded concepts is expected to produce more reliable data, fulfilling better requirements for re-use. The aim was to ascertain what kind of relation exist between coded nursing diagnoses, nursing interventions, and nursing intensity and to discuss the possibilities for re-using nursing data for workload design. Read More

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December 2018

The Barrow Innovation Center: A Novel Program in Neurosurgery Resident Education and Medical Device Innovation.

Cureus 2018 Feb 2;10(2):e2142. Epub 2018 Feb 2.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, USA.

Medical innovation is the application of scientific knowledge and problem solving for the betterment of the human condition. Every great advancement in the field of neurosurgery can be traced back to a novel surgical procedure or technology that challenged existing standards of care. Considering the critical importance of innovation to the advancement of neurosurgery, and a surprising lack of formal training in innovation among residency programs, we sought to create a residency training program in neurosurgical innovation. Read More

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February 2018
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Parental Occupational Exposures and Risk of Childhood Acute Leukemia.

Mater Sociomed 2018 Oct;30(3):209-214

Occupational and Industrial Hygiene Department, National School of Public Health, Athens, Greece.

Introduction: Acute leukemia, accounting for 20% of all cancers diagnosed in individuals younger than 19 years old, is the most prevalent childhood malignancy. Among environmental risk factors, parental occupational exposures have attracted scientific interest as potential predisposing factors for childhood leukemia. The role of parental occupational exposure to social contacts, harmful chemicals, electromagnetic fields and ionizing radiation has been investigated with conflicting and inconsistent results. Read More

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October 2018
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