60,125 results match your criteria Contemporary Issues in the Treatment of Schizophrenia[Journal]


An update on Drug Repurposing: Re-written saga of the drug's fate.

Biomed Pharmacother 2018 Dec 12;110:700-716. Epub 2018 Dec 12.

Pharamacological Modelling and Simulation Centre, M.S.Ramaiah University of Applied Sciences, Bangalore, Karnataka, India; Department of Pharmacy Practice, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.

Drug repurposing is an unconventional drug discovery approach to explore new therapeutic benefits of existing, shelved and the drugs in clinical trials. This approach is currently emerging to overcome the bottleneck constraints faced during traditional drug discovery in grounds of financial support, timeline and resources. In this direction, several efforts were made for the construction of stratagems based on bioinformatics and computational tools to intensify the repurposing process off-late. Read More

View Article
December 2018
1 Read

Open Thoracoabdominal Aortic Aneurysm Repair: Contemporary Outcomes for 393 Elective Cases.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Japan.

Background: The purpose of this study was to reveal the mid- and long-term mortality rates among patients with thoracoabdominal aortic aneurysm (TAAA) following open TAAA repair (TAAAR) and to clarify the impact of aneurysm type on mortality.

Methods: We retrospectively analyzed data for 393 patients (290 males; age, 63.2 ± 12. Read More

View Article
December 2018

Genetic association of non-MHC region with ankylosing spondylitis in a Chinese population.

Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.

State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China

View Article
December 2018

Oral medicine: Today's future can become tomorrow's reality.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Nov 22;126(5):409-414. Epub 2018 Aug 22.

Professor and Head, Oral Medicine, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine; Co-chair, Head & Neck Cancer/Oral Oncology Program, Neag Comprehensive Cancer Center, UConn Health Farmington, CT, USA.

There have been strategic clinical, educational, and research advances in the field of Oral Medicine over the past several decades. In many cases, Oral Medicine experts are contributing the lead role in these advances nationally and internationally. In addition, American Board of Dental Specialty recognition of Oral Medicine as a specialty in 2015 has positioned Oral Medicine professionals to substantively enhance the delivery of oral health care to medically complex patients as well. Read More

View Article
November 2018

Eco-evolutionary feedbacks following changes in spatial connectedness.

Curr Opin Insect Sci 2018 Oct 27;29:64-70. Epub 2018 Jun 27.

Ghent University, Dept. of Biology, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.

Humans are drastically changing the spatial configuration of habitats. The associated changes in habitat connectedness impose strong selection on dispersal, and dispersal related traits. Evolutionary responses do, however, strongly feedback on the metapopulation dynamics, by further constraining or improving connectivity and impacting local population and food web dynamics. Read More

View Article
October 2018

Barriers to implementing diagnostic domestic violence screening.

Pract Midwife 2017 May;20(5):8-11

In the United Kingdom, Australia, the United States of America and Europe, universal and routine screening is recommended for pregnant women, extending into the postnatal period. However, the lack of self-confidence among midwives and midwifery students, in implementing diagnostic domestic violence screening, is consistent within the contemporary literature, and has significant implications for the health of women and their families.The evidence for this lack of confidence centres around three professional issues surrounding domestic violence screening from a midwifery context: time constraints; midwifery education; and midwives as recipients of domestic violence. Read More

View Article

Malariablood in the pocket.

Authors:
Stefan Wulf

Medizinhist J 2017 ;52(1):2-40

For the first time on June 5, 1919, at the Hamburg State Hospital Friedrichsberg, two paralytics were artificially infected with malaria, subjecting them to the new malaria fever treatment according to Wagner-Jauregg (1917). This article examines the life stories and medical histories of these patients, an opera singer and a yardmaster, and provides an interpretation based on their medical files. Relevant contemporary medical publications contextualise the specific configurations of their hospital stay. Read More

View Article
January 2017

New Directions in the Historiography of Psychiatry.

J Hist Med Allied Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of History, University of Rochester.

Gerald Grob's work in the history of psychiatry over the course of almost fifty years created a model for how historians might successfully situate mental health in its social and political context, and how inseparable it was from this context. Over the last twenty years, the field has grown tremendously. Historians have incorporated categories of analysis like gender and race, methodologies like cultural history and intellectual history, and sought to continue Grob's quest to understand American mental health history as a critical component of American history writ large. Read More

View Article
December 2018
1 Read

Multi-segment spine kinematics: Relationship with dance training and low back pain.

Gait Posture 2018 Dec 4;68:274-279. Epub 2018 Dec 4.

Centre for Sport Research, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia; Sport Performance Research Institute New Zealand, Auckland University of Technology, 17 Antares Place, Rosedale, Auckland 0632, New Zealand. Electronic address:

Background: Spine posture, range of motion (ROM) and movement asymmetry can contribute to low back pain (LBP). These variables may have greater impact in populations required to perform repetitive spine movements, such as dancers; however, there is limited evidence to support this.

Research Question: What is the influence of dance and LBP on spinal kinematics?

Methods: In this cross-sectional study, multi-segment spinal kinematics were examined in 60 female participants, including dancers (n = 21) and non-dancers (n = 39) with LBP (n = 33) and without LBP (n = 27). Read More

View Article
December 2018
1 Read

Metallic Endobronchial Stents - A Contemporary Resurrection.

Chest 2018 Dec 11. Epub 2018 Dec 11.

Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States.

View Article
December 2018

Occupational exposure to metals and other elements in the tractor production.

PLoS One 2018 14;13(12):e0208932. Epub 2018 Dec 14.

National Center of Occupational Safety and Health, Minsk, Belarus.

Background: Exposure to metals via air sampling in workplace has been extensively studied; however, the magnitude of individual exposure in various occupational groups may vary dramatically. The aim of this cross-sectional study was to ascertain exposure to selected metals from metal fumes in a series of typical workplaces of contemporary tractor production.

Methods: Ninety-eight (median age 41 (interquartile range (IQR) 23) years, all men) workers from Minsk Tractor Plant were categorized into four groups, including assembly shop workers (group 1); thermal shop staff (group 2); steelmakers (group 3) and welders (group 4). Read More

View Article
December 2018

Toward a dimensional model of vocational interests.

J Appl Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Educational Psychology.

Growing evidence on the predictive validity of vocational interests for job performance calls for greater consideration of interest assessment in organizations. However, a consensus on the fundamental dimensions of interests that are aligned with the contemporary world of work is still lacking. In the current research, we developed an organizing framework of vocational interests and empirically validated an 8-dimension model (SETPOINT: Health Science, Creative xpression, echnology, eople, rganization, nfluence, ature, and hings). Read More

View Article
December 2018

Left Ventricular Reverse Remodeling in Recent Onset Idiopathic Dilated Cardiomyopathy Using Contemporary Echo Techniques.

Isr Med Assoc J 2018 Dec;20(12):749-753

Heart Institute, Kaplan Medical Center, Rehovot, Israel.

Background: Early identification of patients with a likelihood of cardiac improvement has important implications for management strategies.

Objectives: To evaluate whether tissue Doppler imaging (TDI) and two-dimensional (2D) strain measures may predict left ventricular (LV) improvement in patients with recent onset dilated cardiomyopathy (ROCM).

Methods: Clinical and comprehensive echo were performed at baseline and at 6 months. Read More

View Article
December 2018

Contemporary management of primary parapharyngeal space tumors.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Coordinator of the International Head and Neck Scientific Group.

The parapharyngeal space is a complex anatomical area. Primary parapharyngeal tumors are rare tumors and 80% of them are benign. A variety of tumor types can develop in this location; most common are salivary gland neoplasm and neurogenic tumors. Read More

View Article
December 2018

Proton Relays in Molecular Catalysis of Electrochemical Reactions.

Angew Chem Int Ed Engl 2018 Dec 13. Epub 2018 Dec 13.

Universite Paris Diderot, Chemistry, 15 rue Jean de Baif, 75013, Paris, FRANCE.

In the current development of homogeneous catalysis of electrochemical reactions, related to contemporary renewable energy challenges, catalytic reaction schemes often involves proton coupled electron transfer sequences. The proton source (or sink) may then be an acid (or a base) present in the solution acting as a cosubstrate participating stoichiometrically and kinetically to the catalytic process. On this ground, the idea has soon emerged that installing the proton donor (for reductions, or acceptor for oxidations) inside the catalyst molecule should be beneficial in terms of efficiency, since it would then be closer to the nerve center of the process (usually the metal in the case of transition metal complex catalysts). Read More

View Article
December 2018
1 Read

Contemporary Management of Direct Oral Anticoagulants During Cardioversion and Ablation for Nonvalvular Atrial Fibrillation.

Pharmacotherapy 2018 Dec 12. Epub 2018 Dec 12.

Professor of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee.

Introduction: As overall prevalence of atrial fibrillation (AF) continues to rise, the number of patients who undergo ablation, or electrical/chemical cardioversion, to restore normal sinus rhythm continues to increase as well. As direct oral anticoagulants (DOACs) have continued to be incorporated into clinical practice for long-term anticoagulation for AF, experience with how best to manage use of DOACs during electrophysiologic procedures is evolving.

Objective: This review is intended to provide health care providers with a summary of current evidence regarding the use of DOACs during cardioversion and catheter ablation and provide key considerations for their use during such electrophysiologic procedures. Read More

View Article
December 2018

Anastomosis of the outflow cannula to the descending aorta in a HeartWare left ventricular assist device.

J Cardiol Cases 2015 Feb 15;11(2):66-68. Epub 2014 Nov 15.

Department of Surgery, Division of Cardiothoracic Surgery, University of Minnesota, Minneapolis, MN, USA.

We report a case in which a recipient of a HeartWare HVAD left ventricular assist device (HeartWare, Framingham, MA, USA) was unable to undergo standard outflow graft anastomosis to the ascending aorta due to severe aortic calcification. The outflow graft of the device was instead anastomosed to the descending aorta. < Not all left ventricular assist device (LVAD) patients are candidates for outflow graft anastomosis to the ascending aorta. Read More

View Article
February 2015

What makes people ready to conceive? Findings from the International Fertility Decision-Making Study.

Reprod Biomed Soc Online 2018 Aug 10;6:90-101. Epub 2018 Nov 10.

School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK.

This study investigated fertility decision-making in people currently trying to conceive, and examined whether factors that make people ready to conceive differ by gender and country. The study used data from the International Fertility Decision-Making Study, a cross-sectional study of 10,045 participants (1690 men and 8355 women) from 79 countries. Respondents were aged 18-50 years (mean 31. Read More

View Article

Contemporary Surgical Management of Deep-Seated Metastatic Brain Tumors Using Minimally Invasive Approaches.

Front Oncol 2018 28;8:558. Epub 2018 Nov 28.

Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, United States.

A subset of metastatic brain tumors occurs in deep-seated locations. Accessing and resecting these lesions can be associated with significant morbidity because it involves large craniotomies, extensive white matter dissection, prolonged retraction, and risk of inadvertent tissue injury. As a result, only palliative treatment options are typically offered for these lesions including observation, needle biopsies, and/or radiation therapy. Read More

View Article
November 2018
1 Read

Healthy Life Centre participants' perceptions of living with overweight or obesity and seeking help for a perceived "wrong" lifestyle - a qualitative interview study.

BMC Obes 2018 6;5:42. Epub 2018 Dec 6.

1Faculty of Health and Social Sciences, Department of Health and Caring Science, Western Norway University of Applied Sciences, Bjørnsons gate 45, 5528 Haugesund, Norway.

Background: Overweight and obesity are complex conditions, associated with a wide range of serious health issues. In contemporary society, body size is an important part of a person's self-representation. Lifestyle changes are difficult and long-term weight management is associated with a high risk of failure. Read More

View Article
December 2018
1 Read

Analysis of Contemporary Violin Recordings of 19th Century Repertoire: Identifying Trends and Impacts.

Front Psychol 2018 27;9:2233. Epub 2018 Nov 27.

Faculty of Music Education, Levinsky College of Education, Tel Aviv, Israel.

The study of violin recordings as evidence of interpretation and performance approach has been quite extensive throughout recent decades. Findings such as the limited use of vibrato in early recordings, the relative stabilization of tempo and rhythm characteristic of mid-20th century violin playing, or the effect of 'historically informed performance' (HIP) on 'mainstream' (MS) violinists performing early music repertoire, are fundamental in the identification of prevailing norms of practice and changes of style that have occurred over time. However, compared to the considerable amount of research conducted on 20th century playing, studies focusing on 21st century violin performances are still quite limited, and are mostly based on recordings of J. Read More

View Article
November 2018

Captive to the Clinic: Phase I Clinical Trials as Temporal Total Institutions.

Sociol Inq 2018 Nov 20;88(4):724-748. Epub 2018 Apr 20.

This article develops the concept of to describe how and why individuals voluntarily submit to highly-controlled and often dehumanizing environments. We focus empirically on Phase I clinical trials, which offer compensation to healthy people in exchange for testing investigational pharmaceuticals. Analyzing the experiences of 67 U. Read More

View Article
November 2018

Contemporary patient-tailored treatment strategies against high risk and relapsed or refractory multiple myeloma.

EBioMedicine 2018 Dec 10. Epub 2018 Dec 10.

Department of Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Recurrence of disease due to chemotherapy drug resistance remains a major obstacle to a more successful survival outcome of multiple myeloma (MM). Overcoming drug resistance and salvaging patients with relapsed and/or refractory (R/R) MM is an urgent and unmet medical need. Several new personalized treatment strategies have been developed against molecular targets to overcome this drug resistance. Read More

View Article
December 2018

Integrative approach for diabetic foot management- a case report.

J Ayurveda Integr Med 2018 Dec 10. Epub 2018 Dec 10.

Institute of Ayurveda and Integrative Medicine, Trans Disciplinary University, No.74/2, Jarakabandekaval Post Attur, Via Yelahanka, Bangalore, 560 064, Karnataka, India.

Non-healing diabetic foot has always demanded more attention from the surgeon due to the distinct problem it possesses. There is a constant need for the evolvement in the management and this case is one such attempt. A 62-year-old male patient with a history of diabetes mellitus since 10 years presented with a non-healing foot ulcer since 1 month. Read More

View Article
December 2018

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry.

J Prosthet Dent 2018 Dec;120(6):816-878

Private practice oral and maxillofacial surgery, Ansbach, Bavaria, Germany.

Problem: There are countless numbers of scientific studies published in countless scientific journals on subjects related to restorative dentistry.

Purpose: The purpose of this article is to review pertinent scientific studies published in 2017 on topics of interest to restorative dentists.

Methods And Materials: The authors, considered to be experts in their disciplines searched the scientific literature in 7 different areas (prosthodontics, periodontics, dental materials, occlusion and temporomandibular disorders, sleep-disordered breathing, oral medicine and oral and maxillofacial surgery and dental caries). Read More

View Article
December 2018
1 Read

The gingival health status of 8-12 year-old children in Damascus city in Syria during the Syrian Crisis: a cross-sectional epidemiological oral health survey.

BMC Res Notes 2018 Dec 13;11(1):887. Epub 2018 Dec 13.

Paediatric Dentistry Department, Faculty of Dentistry, Damascus University, Damascus, Syria.

Objective: The aim of this study was to assess the current gingival health status in children aged 8-12 years in Damascus city. No contemporary data was available with an immense need for studies evaluating the gingival health status in Syrian children, especially under the current circumstances of the Syrian crisis.

Results: The study followed the school-based health survey model using stratified random cluster sampling. Read More

View Article
December 2018

Ancient Ancestry Informative Markers for Identifying Fine-Scale Ancient Population Structure in Eurasians.

Genes (Basel) 2018 Dec 12;9(12). Epub 2018 Dec 12.

Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK.

The rapid accumulation of ancient human genomes from various areas and time periods potentially enables the expansion of studies of biodiversity, biogeography, forensics, population history, and epidemiology into past populations. However, most ancient DNA (aDNA) data were generated through microarrays designed for modern-day populations, which are known to misrepresent the population structure. Past studies addressed these problems by using ancestry informative markers (AIMs). Read More

View Article
December 2018

An Improved Analytical Solution for Process-Induced Residual Stresses and Deformations in Flat Composite Laminates Considering Thermo-Viscoelastic Effects.

Authors:
Chao Liu Yaoyao Shi

Materials (Basel) 2018 Dec 10;11(12). Epub 2018 Dec 10.

The Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Xi'an 710072, China.

Dimensional control can be a major concern in the processing of composite structures. Compared to numerical models based on finite element methods, the analytical method can provide a faster prediction of process-induced residual stresses and deformations with a certain level of accuracy. It can explain the underlying mechanisms. Read More

View Article
December 2018
1 Read

Childhood trauma in mood disorders: Neurobiological mechanisms and implications for treatment.

Pharmacol Rep 2018 Oct 11;71(1):112-120. Epub 2018 Oct 11.

Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland. Electronic address:

A contemporary model for the pathogenesis of mood disorders (bipolar and depressive disorders) involves gene-environmental interaction, with genetic predisposition, epigenetic regulation, and environmental effects. Among multiple environmental factors, the experience of childhood trauma can be connected with the pathogenesis, course and the treatment of mood disorders. Patients with mood disorders have the greater frequency of childhood trauma compared with the general population, and adverse childhood experiences can exert a negative impact on their clinical course. Read More

View Article
October 2018

Minimally Invasive and Robotic Esophagectomy: A Review.

Innovations (Phila) 2018 Nov/Dec;13(6):391-403

Division of Thoracic Surgery, Robert Tucker Hayes Foundation, University of Texas Southwestern Medical Center, Dallas, TX USA.

Great advances have been made in the surgical management of esophageal disease since the first description of esophageal resection in 1913. We are in the era of minimally invasive esophagectomy. The current three main approaches to an esophagectomy are the Ivor Lewis technique, McKeown technique, and the transhiatal approach to esophagectomy. Read More

View Article
December 2018

Quantifying Sex Differences in Cardiovascular Care Among Patients Evaluated for Suspected Ischemic Heart Disease.

J Womens Health (Larchmt) 2018 Dec 13. Epub 2018 Dec 13.

3 Department of Medicine, New York University School of Medicine , New York, New York.

Background: Cardiovascular care sex differences are controversial. We examined sex differences in management and clinical outcomes among patients undergoing noninvasive testing for ischemic heart disease (IHD).

Methods: In a rural integrated healthcare system, we identified adults age 40-79 without diagnosed IHD who underwent initial evaluation with a cardiac stress test with imaging or coronary computed tomographic angiography (CTA), 2013-2014. Read More

View Article
December 2018

Practical use of polymer brushes in sustainable energy applications: interfacial nanoarchitectonics for high-efficiency devices.

Chem Soc Rev 2018 Dec 13. Epub 2018 Dec 13.

Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, Diagonal 113 y 64 (1900), La Plata, Argentina.

The discovery and development of novel approaches, materials and manufacturing processes in the field of energy are compelling increasing recognition as a major challenge for contemporary societies. The performance and lifetime of energy devices are critically dependent on nanoscale interfacial phenomena. From the viewpoint of materials design, the improvement of current technologies inevitably relies on gaining control over the complex interface between dissimilar materials. Read More

View Article
December 2018

A coarse-grained multiscale model to simulate morphological changes of food-plant tissues undergoing drying.

Soft Matter 2018 Dec 13. Epub 2018 Dec 13.

School of Chemistry, Physics, and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, 2 George St, Brisbane, 4001, Australia.

Numerical modelling has emerged as a powerful and effective tool to study various dynamic behaviours of biological matter. Such numerical modelling tools have contributed to the optimisations of food drying parameters leading to higher quality end-products in the field of food engineering. In this context, one of the most recent developments is the meshfree-based numerical models, which have demonstrated enhanced capabilities to model cellular deformations during drying, providing many benefits compared to conventional grid-based modelling approaches. Read More

View Article
December 2018

Shock - Classification and Pathophysiological Principles of Therapeutics.

Curr Cardiol Rev 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology Bluhm Cardiovascular Institute Feinberg School of Medicine Northwestern University Medical Center, Chicago, Illinois, IL. United States.

The management of patients with shock is extremely challenging because of the myriad of possible clinical presentations in cardiogenic shock, septic shock and hypovolemic shock and the limitations of contemporary therapeutic options. The treatment of shock includes the administration of endogenous catecholamines (epinephrine, norepinephrine, and dopamine) as well as various vasopressor agents that have shown efficacy in the treatment of the various types of shock. In addition to the endogenous catecholamines, dobutamine, isoproterenol, phenylephrine, and milrinone have served as the mainstays of shock therapy for several decades. Read More

View Article
December 2018

Contemporary Outcomes of Pediatric Restrictive Cardiomyopathy: A Single-Center Experience.

Pediatr Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Cincinnati Children's Hospital Medical Center, Heart Institute, Cincinnati, OH, USA.

Background: Pediatric restrictive cardiomyopathy (RCM) has high mortality in historical cohorts, and traditional management often involves early referral for heart transplantation (HTx). This study sought to determine outcomes of pediatric RCM at a center that has favored medical management over early listing for HTx.

Methods: All patients (N = 43) with pure RCM phenotype (RCM, N = 26) and hypertrophic cardiomyopathy with restrictive physiology (RCM/HCM, N = 17) managed at our center over a 15-year period were investigated. Read More

View Article
December 2018

Strain Tunable Bandgap and High Carrier Mobility in SiAs and SiAs Monolayers from First-Principles Studies.

Nanoscale Res Lett 2018 Dec 12;13(1):404. Epub 2018 Dec 12.

International Laboratory for Quantum Functional Materials of Henan, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.

Searching for new stable free-standing atomically thin two-dimensional (2D) materials is of great interest in the fundamental and practical aspects of contemporary material sciences. Recently, the synthesis of layered SiAs single crystals has been realized, which indicates that their few layer structure can be mechanically exfoliated. Performing a first-principles density functional theory calculations, we proposed two dynamically and thermodynamically stable semiconducting SiAs and SiAs monolayers. Read More

View Article
December 2018

Strengthening ethical community engagement in contemporary Malawi.

Wellcome Open Res 2018 18;3:115. Epub 2018 Sep 18.

The Ethox Centre/ Wellcome Centre for Ethics and Humanities, University of Oxford, Oxford, UK.

Although community engagement is increasingly promoted in global health research to improve ethical research practice, there is sometimes a disconnect between the broader moral ambitions for community engagement in the literature and guidelines on the one hand and its rather narrower practical application in health research on the other. In practice, less attention is paid to engaging communities for the 'intrinsic' value of showing respect and ensuring inclusive participation of community partners in research design. Rather, more attention is paid to the use of community engagement for 'instrumental' purposes to improve community understanding of research and ensure successful study implementation. Read More

View Article
September 2018

A case of nephrotic syndrome showing contemporary presence of apolipoprotein E2 homozygote glomerulopathy and membranous nephropathy-like findings modified by apolipoprotein E Toyonaka.

Clin Nephrol Case Stud 2018 30;6:45-51. Epub 2018 Nov 30.

Division of Nephrology, Kansai Electric Power Hospital.

A 79-year-old man was admitted to our hospital for proteinuria due to nephrotic syndrome. Renal biopsy revealed focal sclerosis and foam cell infiltration in the glomerulus. In addition, electron microscopic findings (EM) revealed peculiar electron-dense deposits (EDDs) in both sides of the glomerular basement membrane. Read More

View Article
November 2018

From bedside to bench and back again: translational studies of mechanical unloading of the left ventricle to promote recovery after acute myocardial infarction.

F1000Res 2018 27;7. Epub 2018 Nov 27.

Cardiovascular Research Center, Mount Sinai School of Medicine, New York, New York, USA.

Heart failure is a major cause of global morbidity and mortality. Acute myocardial infarction (AMI) is a primary cause of heart failure due in large part to residual myocardial damage despite timely reperfusion therapy. Since the 1970's, multiple preclinical laboratories have tested whether reducing myocardial oxygen demand with a mechanical support pump can reduce infarct size in AMI. Read More

View Article
November 2018

John Bowlby and contemporary issues of clinical diagnosis.

Attachment (Lond) 2018 Aug;12(1):35-47

Primary Care Unit, Cambridge University.

View Article

Increased expression of EZH2 indicates aggressive potential of urothelial carcinoma of the bladder in a Chinese population.

Sci Rep 2018 Dec 12;8(1):17792. Epub 2018 Dec 12.

Urology Institute of People Liberation Army, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Here, we attempt to better define the long-term outcomes of radical cystectomy (RC) for urothelial carcinoma (UC) in a Chinese population and to investigate the relationship between EZH2 protein expression levels and the clinicopathological parameters and outcomes in patients with UC. We detected the relative EZH2 protein expression levels by immunohistochemistry in tumour specimens from a cohort of 189 Chinese UC patients. In patients who underwent RC, the 5-year cancer-specific survival (CSS) and overall survival (OS) were 69% and 61% respectively. Read More

View Article
December 2018

Rationale, design, and methods for the Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD) study.

BMC Pregnancy Childbirth 2018 Dec 12;18(1):488. Epub 2018 Dec 12.

The University of North Carolina at Chapel Hill School of Medicine, Campus Box 7516, Chapel Hill, NC, 27599-7516, USA.

Background: Annually in the US, over 100,000 pregnant women with overt type 2 diabetes give birth. Strict maternal glycemic control is the key to optimizing infant outcomes. Medical treatment of type 2 diabetes in pregnancy is generally restricted to insulin, as data on the safety and efficacy of oral hypoglycemic agents in pregnancy are limited. Read More

View Article
December 2018

Phylogeography of a widespread lizard complex reflects patterns of both geographic and ecological isolation.

Mol Ecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA, 94705, USA.

A primary challenge for modern phylogeography is understanding how ecology and geography, both contemporary and historical, shape the spatial distribution and evolutionary histories of species. Phylogeographic patterns are the result of many factors, including geology, climate, habitat, colonization history, and lineage-specific constraints. Assessing the relative influences of these factors is difficult because few species, regions, and environments are sampled in enough detail to compare competing hypotheses rigorously and because a particular phylogeographic pattern can potentially result from different evolutionary scenarios. Read More

View Article
December 2018

Early structural valve deterioration and reoperation associated with the mitroflow aortic valve.

J Card Surg 2018 Dec 7. Epub 2018 Dec 7.

Corrigan Minehan Heart Center and Division of Cardiac Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: Structural valve deterioration (SVD) is a known limitation of bioprosthetic valves. Recent reports have suggested a concerning rate of early SVD in patients receiving a Mitroflow aortic bioprosthesis. We therefore compared the incidence of SVD and SVD requiring reoperation among patients receiving a Mitroflow versus a common contemporary bioprosthesis. Read More

View Article
December 2018

Quantitative Genetics and Genomics Converge to Accelerate Forest Tree Breeding.

Front Plant Sci 2018 22;9:1693. Epub 2018 Nov 22.

Department of Forest and Conservation Sciences, Faculty of Forestry, University of British Columbia Vancouver, BC, Canada.

Forest tree breeding has been successful at delivering genetically improved material for multiple traits based on recurrent cycles of selection, mating, and testing. However, long breeding cycles, late flowering, variable juvenile-mature correlations, emerging pests and diseases, climate, and market changes, all pose formidable challenges. Genetic dissection approaches such as quantitative trait mapping and association genetics have been fruitless to effectively drive operational marker-assisted selection (MAS) in forest trees, largely because of the complex multifactorial inheritance of most, if not all traits of interest. Read More

View Article
November 2018

Assessment of Unilateral Spatial Neglect Using a Free Mobile Application for Italian Clinicians.

Front Psychol 2018 22;9:2241. Epub 2018 Nov 22.

Applied Technology for Neuro-Psychology Lab, Istituto Auxologico Italiano, Milan, Italy.

Unilateral Spatial Neglect (USN) is traditionally assessed with paper-and-pencil tests or computer-based tests. Thanks to the wide-spreading of mobile devices, and the extensive capabilities that they have in dealing complex elements, it is possible to provide clinicians with tools for cognitive assessment. Contemporary 3D engine is, in general generally, able to deploy complex 3D environments for iOS, Android and Windows mobile, i. Read More

View Article
November 2018

The unraveling of Amsterdam's unitary rental system.

J Hous Built Environ 2018 6;33(4):633-651. Epub 2018 Mar 6.

1Centre for Urban Studies, University of Amsterdam, Amsterdam, The Netherlands.

The Netherlands has traditionally been considered an iconic 'unitary' rental housing market in which social and private sectors directly compete. More recently however, this unitary market has been undermined by changes in the status of housing associations, the privatization of social housing stock and the promotion of home ownership. It has subsequently been suggested that the Netherlands is drifting toward a 'dualist' system in which social and private sectors are critically unequal. Read More

View Article

The Impact of Stress on Pressure Ulcer Wound Healing Process and on the Psychophysiological Environment of the Individual Suffering from them.

Med Arch 2018 Nov;72(5):362-366

Nursing Program and Postgraduate program Contemporary Nursing, University of Nicosia, Nicosia, Cyprus.

Introduction: The occurrence of a pressure ulcer constitutes a major psychological and physiological burden and it has been linked with a reduced quality of life and increased stress of the individual.

Objective: The main objective was to investigate the impact that stress has on pressure ulcer healing process and on the psychophysiological environment of the individual suffering from them.

Method: The scientific literature was reviewed through Cinahl, Pub-med, EBSCO, Medline and Google scholar. Read More

View Article
November 2018

Past and Present of Eye Movement Abnormalities in Ataxia-Telangiectasia.

Cerebellum 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurology, Neurology Service, Cleveland VA Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44110, USA.

Ataxia-telangiectasia is the second most common autosomal recessive hereditary ataxia, with an estimated incidence of 1 in 100,000 births. Besides ataxia and ocular telangiectasias, eye movement abnormalities have long been associated with this disorder and is frequently present in almost all patients. A handful of studies have described the phenomenology of ocular motor deficits in ataxia-telangiectasia. Read More

View Article
December 2018