60,926 results match your criteria Contemporary Issues in the Treatment of Schizophrenia[Journal]


A randomized, double-blind, placebo-controlled trial to assess the efficAcy and safety of Trimetazidine in patients with angina pectoris having been treated by percutaneous coronary intervention (ATPCI study): Rationale, design, and baseline characteristics.

Am Heart J 2019 Jan 15;210:98-107. Epub 2019 Jan 15.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), Department of Cardiology, Paris, France; Université Paris-Descartes, Paris, France; INSERM U-970, Paris, France.

Background: About 30% of angina patients have persisting symptoms despite successful revascularization and antianginal therapy. Moreover, in stable patients, percutaneous coronary intervention (PCI) does not improve survival as compared with medical therapy alone. Trimetazidine, an antianginal agent devoid of hemodynamic effect, may help reducing symptoms and improving outcomes after PCI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00028703193000
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http://dx.doi.org/10.1016/j.ahj.2018.12.015DOI Listing
January 2019
2 Reads

Direct and indirect effects of perception on generalization gradients.

Behav Res Ther 2019 Jan 18;114:44-50. Epub 2019 Jan 18.

Center for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Tiensestraat 102, Box 3712, 3000, Leuven, Belgium.

For more than a century, researchers have attempted to understand why organisms behave similarly across situations. Despite the robust character of generalization, considerable variation in conditioned responding both between and within humans remains a challenge for contemporary generalization models. The current study aims to investigate the extent to which variation in behavior in a context of generalization can be attributed to differences in perception. Read More

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http://dx.doi.org/10.1016/j.brat.2019.01.006DOI Listing
January 2019

Contemporary trends of pelvic lymph node dissection at radical cystectomy for urothelial carcinoma of urinary bladder and associated cancer specific mortality and complications: comparison between octogenarian versus younger patients.

Cancer Epidemiol 2019 Feb 13;59:135-142. Epub 2019 Feb 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age.

Materials And Methods: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified. Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.002DOI Listing
February 2019

Isolated teeth from La Ferrassie: Reassessment of the old collections, new remains, and their implications.

Am J Phys Anthropol 2019 Feb 16. Epub 2019 Feb 16.

Département Homme et environnement, Muséum national d'Histoire naturelle, Musée de l'Homme, UMR 7194 CNRS, Université de Perpignan "Via Domitia", EPCC-CERP de Tautavel, Paris, France.

Objectives: We provide the description and comparative analysis of six new teeth from the site of La Ferrassie. Our goal is to discuss their taxonomic attribution, and to provide an updated inventory of Neandertal and modern human remains from La Ferrassie in their associated archeological context.

Materials And Methods: We use external and internal anatomy, classic morphometrics, and geometric morphometrics. Read More

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http://doi.wiley.com/10.1002/ajpa.23798
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http://dx.doi.org/10.1002/ajpa.23798DOI Listing
February 2019
3 Reads

Diagnosis and Management of CMV Colitis.

Curr Infect Dis Rep 2019 Feb 15;21(2). Epub 2019 Feb 15.

Pediatric Gastroenterology Unit, Pediatrics Department, "Dana-Dwek" Children's Hospital, Tel Aviv Sourasky Medical Center, 6 Weizman Street, 6423906, Tel Aviv, Israel.

Purpose Of Review: Cytomegalovirus (CMV) colitis is a relatively common end-organ infectious complication in immunocompromised hosts which negatively affects clinical outcomes. This paper presents the contemporary approaches to the diagnosis and management of CMV colitis and discusses some of the controversies of this condition, focusing on methods of diagnosis.

Recent Findings: While certain risk factors for CMV colitis are well recognized, the clinical as well as endoscopic features of this condition are nonspecific. Read More

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http://dx.doi.org/10.1007/s11908-019-0664-yDOI Listing
February 2019

Time from definitive therapy to onset of metastatic disease predicts outcomes in men with metastatic hormone sensitive prostate cancer.

Urol Oncol 2019 Feb 13. Epub 2019 Feb 13.

Division of Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT. Electronic address:

Purpose: Contemporary treatment for metastatic hormone sensitive prostate cancer (mHSPC) includes androgen deprivation therapy (ADT) plus abiraterone or docetaxel. While these intensified regimens have improved efficacy, they are also associated with increased cost and toxicities. Not all men with mHSPC may be candidates for these intensified regimens, yet there are no clinical models or biomarkers used to optimize treatment selection. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.029DOI Listing
February 2019
1 Read

Intratympanic Steroid Use for Sudden Sensorineural Hearing Loss: Current Otolaryngology Practice.

Ann Otol Rhinol Laryngol 2019 Feb 15:3489419828759. Epub 2019 Feb 15.

1 Royal National Throat, Nose and Ear Hospital, University College London Hospitals NHS Trust, London, UK.

Objective:: To investigate the current practice of intratympanic steroid (ITS) injection for sudden sensorineural hearing loss (SSNHL) in the United Kingdom and link the data with data from the United States and continental Europe.

Methods:: A survey of 21 questions was distributed to members of the British Society of Otology using an online survey platform via ENT UK. Data obtained from UK otolaryngologists (n = 171) were integrated with previously published data from other countries, including the United States (n = 63) and continental Europe (n = 908). Read More

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http://dx.doi.org/10.1177/0003489419828759DOI Listing
February 2019

Outcomes After Reduced-Dose Intensity Modulated Radiation Therapy for Gastric Mucosa- Associated Lymphoid Tissue (MALT) Lymphoma.

Int J Radiat Oncol Biol Phys 2019 Feb 12. Epub 2019 Feb 12.

Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Purpose/objectives: In patients with gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), the standard radiation therapy (RT) dose is ≥ 30 Gy. We report the outcome of patients treated with reduced 24 Gy compared with ≥ 30 Gy.

Materials/methods: We reviewed 32 patients diagnosed between 2007 and 2017 with gastric MALT lymphoma and treated with involved site radiation therapy (ISRT) using intensity modulated radiation therapy (IMRT). Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.002DOI Listing
February 2019

Impact of Right Ventricular Dysfunction on Mortality in Adults with Cardiac Arrest Undergoing Coronary Angiogram.

Resuscitation 2019 Feb 12. Epub 2019 Feb 12.

Division of Cardiovascular Medicine, Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA.

Objective: We sought to identify the impact of echocardiographic right ventricular (RV) systolic dysfunction on mortality in adults with cardiac arrest (CA).

Methods: The study population included 147 adults hospitalized with CA who underwent both echocardiogram and coronary angiogram at an academic tertiary medical center. The primary outcome of interest was all-cause in-hospital mortality. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.003DOI Listing
February 2019

Normalization of large-scale behavioural data collected from zebrafish.

PLoS One 2019 15;14(2):e0212234. Epub 2019 Feb 15.

Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America.

Many contemporary neuroscience experiments utilize high-throughput approaches to simultaneously collect behavioural data from many animals. The resulting data are often complex in structure and are subjected to systematic biases, which require new approaches for analysis and normalization. This study addressed the normalization need by establishing an approach based on linear-regression modeling. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212234PLOS
February 2019

Cross-cultural comparisons of aerobic and muscular fitness in Tanzanian and English youth: An allometric approach.

PLoS One 2019 15;14(2):e0211414. Epub 2019 Feb 15.

Faculty of Education, Health and Wellbeing, University of Wolverhampton, Walsall, United Kingdom.

Comparisons of physical fitness measures between children or within group measures over time are potentially confounded by differences in body size. We compared measures of strength (handgrip) and aerobic fitness (running-speed [20m shuttle-run]) of 10.0-15. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211414PLOS
February 2019

Simultaneous Formation of cis- and trans-CHOCu(OH) Intermediates in Methane Activation by Cu in Solid Ar.

Inorg Chem 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemistry and State Key Laboratory of Advanced Textiles Materials and Manufacture Technology, Ministry of Education , Zhejiang Sci-Tech University , Hangzhou 310018 , China.

Understanding the mechanisms of methane activation is an important and active research area of the contemporary catalyzed conversion of hydrocarbons to shippable, valuable feedstock and has invoked close collaborations between experimentalists and theorists. This article describes the trapping of reaction intermediates in a copper-catalyzed direct methane-to-methanol conversion. Specifically, two hydroxy(methoxy)copper(I) [CHOCu(OH)] isomeric intermediates were distinguished and characterized by matrix isolation infrared spectroscopy and O, CD, and CH isotopic substitution experiments combined with quantum chemical calculations. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03322DOI Listing
February 2019

Use of Digital Technology to Fabricate an Anterior Fixed Restoration Supported by a Dental Implant and Natural Teeth.

Compend Contin Educ Dent 2019 Feb;40(2):108-112

Clinical Professor of Restorative Dentistry, Kornberg School of Dentistry, Temple University, Philadelphia, Pennsylvania; Clinical Professor of Periodontics, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania; Private Practice, Villanova, Pennsylvania.

As digital technology increasingly permeates the practice of dentistry, intraoral digital impression scanning is evolving rapidly. New systems are making the capture of digital impressions faster and easier than previous generations of digital impression scanners. This case report describes the use of a contemporary intraoral impression scanner to capture tooth and soft-tissue positions for a four-unit fixed prosthesis and accompanying custom dental implant abutment. Read More

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February 2019

Le médicament augmenté : l?usage du médicament dans les discours transhumanistes et ses significations sociales.

J Int Bioethique Ethique Sci 2018 Dec;29(3):93-108

Though NBICs and their overlap are at the heart of transhumanist claims in favour of human enhancement, medication also occupies a central place. In many of the movement's writings and lectures, it is one of the primary means systematically considered to extend human biological boundaries and improve physical, intellectual and emotional performance. Taking a sociological perspective, this article aims to explore the role and meaning medication holds in transhumanist discourse. Read More

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http://dx.doi.org/10.3917/jibes.293.0093DOI Listing
December 2018

Plus vite, plus haut, plus fort, plus? Pour aller où  Transhumanisme et aspiration au bonheur.

J Int Bioethique Ethique Sci 2018 Dec;29(3):170-188

Human beings desire to become better. Education and development of tools have helped them to reach this goal for many a time. But what is the ultimate goal? A classical answer is: to be happy. Read More

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http://dx.doi.org/10.3917/jibes.293.0170DOI Listing
December 2018

Postpartum depression prevalence and risk factors among Indigenous, non-Indigenous and immigrant women in Canada.

Can J Public Health 2019 Feb 14. Epub 2019 Feb 14.

Centre for Urban Health Solutions, St. Michael's Hospital, Toronto, Canada.

Objectives: The social position of different minority groups in contemporary societies suggests different risk factors for postpartum depression (PPD). In this study, we used two cut-offs of the Edinburgh Postpartum Depression Scale (EPDS) to examine prevalence and risk factors for PPD among mothers participating in the Canadian Maternity Experiences Survey (MES), and to compare Indigenous, Canadian-born non-Indigenous and immigrant mothers.

Methods: We used cross-sectional nationwide data from the 2006 MES (unweighted N = 6237, weighted N = 74,231) and conducted multivariate logistic regression models for EPDS ≥ 10 and EPDS ≥ 13 to explore risk factors for the total sample of mothers and in each study group. Read More

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http://dx.doi.org/10.17269/s41997-019-00182-8DOI Listing
February 2019

Migrant extractability: Centring the voices of egg providers in cross-border reproduction.

Authors:
Michal Nahman

Reprod Biomed Soc Online 2018 Nov 26;7:82-90. Epub 2018 Nov 26.

University of the West of England, Bristol, UK.

This paper explores reproductive justice from the perspective of those at the beginning of the value chain of reproduction. This vantage point of egg providers can help lend important insights into the wider processes of family-making across borders today. It centres on ethnographic research conducted on contemporary cross-border egg provision performed by female migrant workers in Spain. Read More

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http://dx.doi.org/10.1016/j.rbms.2018.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360401PMC
November 2018

Contemporary imaging methods for the follow-up after endovascular abdominal aneurysm repair: a review.

Wideochir Inne Tech Maloinwazyjne 2019 Jan 15;14(1):1-11. Epub 2018 Oct 15.

Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.

Abdominal aortic aneurysm (AAA) is defined as a localized enlargement of the aortic cross-section where the diameter is greater than 3 cm or more than 50% larger than the diameter in a normal segment. The most important complication of AAA is rupture, which, if untreated, results in mortality rates of up to 90%. Conventional open surgical repair is associated with significant 30-day mortality. Read More

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http://dx.doi.org/10.5114/wiitm.2018.78973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372875PMC
January 2019

The Lawrence D. Dorr Surgical Techniques and Technologies Award: Why Are Contemporary Revision Total Hip Arthroplasties Failing? An Analysis of 2500 Cases.

J Arthroplasty 2019 Jan 23. Epub 2019 Jan 23.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.

Background: As revision implants and techniques have evolved and improved, understanding why contemporary revision total hip arthroplasties (THAs) fail is important to direct further improvement and innovation. As such, the goals of this study are to determine the implant survivorship of contemporary revision THAs, as well as the most common indications for re-revision.

Methods: We retrospectively reviewed 2589 aseptic revision THAs completed at our academic institution between 2005 and 2015 through our total joint registry. Read More

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http://dx.doi.org/10.1016/j.arth.2019.01.031DOI Listing
January 2019

Mentoring Fellows in Adult Cardiothoracic Anesthesiology for Academic Practice in the Contemporary Era-Perspectives From Mentors Around the United States.

J Cardiothorac Vasc Anesth 2019 Jan 9. Epub 2019 Jan 9.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

This special article presents perspectives on the mentoring of fellows for academic practice in adult cardiothoracic anesthesiology. A comprehensive mentoring model should address the areas of clinical care, educational expertise and exposure to scholarly activity. The additional value of educational exposure to patient safety, quality improvement and critical care medicine in this model is also explored. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.024DOI Listing
January 2019

Contemporary Discrepancies of Stenosis Assessment by Computed Tomography and Invasive Coronary Angiography.

Circ Cardiovasc Imaging 2019 Feb;12(2):e007720

Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (Y.B.S., A.A.-Z., M.R.O., A.L.V., J.B., J.A.C.L., J.M.M.).

Background Ongoing advancements of coronary computed tomographic angiography (CTA) continue to challenge the role of invasive coronary angiography (ICA) as the gold standard for the evaluation of coronary artery disease (CAD). We sought to investigate the diagnostic accuracy of 320-slice CTA for detecting obstructive CAD in reference to ICA and nuclear myocardial perfusion imaging using single-photon emission computed tomography. Methods For the CORE320 study (Coronary Artery Evaluation Using 320-Row Multidetector Computed Tomography Angiography and Myocardial Perfusion), 381 patients at 16 centers underwent CTA, nuclear myocardial perfusion imaging by single-photon emission computed tomography, and ICA for the evaluation of CAD. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.007720DOI Listing
February 2019

Current and Emerging Disaster Risks Perceptions in Oceania: Key Stakeholders Recommendations for Disaster Management and Resilience Building.

Int J Environ Res Public Health 2019 Feb 5;16(3). Epub 2019 Feb 5.

Disaster Resilience Initiative, Accident Research Centre, Clayton, Monash University, Melbourne 3800, Australia.

Identification and profiling of current and emerging disaster risks is essential to inform effective disaster risk management practice. Without clear evidence, readiness to accept future threats is low, resulting in decreased ability to detect and anticipate these new threats. A consequential decreased strategic planning for mitigation, adaptation or response results in a lowered resilience capacity. Read More

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http://dx.doi.org/10.3390/ijerph16030460DOI Listing
February 2019

Unravelling population processes over the Late Pleistocene driving contemporary genetic divergence in Palearctic Buzzards.

Mol Phylogenet Evol 2019 Feb 11. Epub 2019 Feb 11.

CIBIO/InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto. Campus de Vairão, 4485-661 Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal; Department of Zoology, University of Johannesburg, PO Box 534, Auckland Park 2006, South Africa.

Population range expansions and contractions as a response to climate and habitat change throughout the Quaternary are known to have contributed to complex phylogenetic and population genetic events. Speciation patterns and processes in Palearctic buzzards (genus Buteo) are a long-standing example of morphological and genetic data incongruence, attributed to panmixia, habitat range shifts, contact zones, and climate change. Here we assess the systematics, phylogeography and population genetic structure of three nominal species of Palearctic buzzards, Buteo buteo (including B. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10557903183060
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http://dx.doi.org/10.1016/j.ympev.2019.02.004DOI Listing
February 2019
1 Read

Rupture of a totally occluded abdominal aortic aneurysm.

Ann Vasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Service de chirurgie vasculaire, CHU ROUEN, FRANCE. Electronic address:

Totally occluded aortic aneurysm is a rare pathology. The medical history and the evolution are unknown. We present a case of a regular followed 60 years old man with chronic thrombosed aneurysm presenting with mycotic acute rupture. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.12.064DOI Listing
February 2019

A natural history model for planning prostate cancer testing: Calibration and validation using Swedish registry data.

PLoS One 2019 14;14(2):e0211918. Epub 2019 Feb 14.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Recent prostate cancer screening trials have given conflicting results and it is unclear how to reduce prostate cancer mortality while minimising overdiagnosis and overtreatment. Prostate cancer testing is a partially observable process, and planning for testing requires either extrapolation from randomised controlled trials or, more flexibly, modelling of the cancer natural history. An existing US prostate cancer natural history model (Gulati et al, Biostatistics 2010;11:707-719) did not model for differences in survival between Gleason 6 and 7 cancers and predicted too few Gleason 7 cancers for contemporary Sweden. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211918PLOS
February 2019

Fetal abdominal cysts: antenatal course and postnatal outcomes.

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK.

Background There is little information on which to base the prognostic counselling as to whether an antenatally diagnosed fetal abdominal cyst will grow or shrink, or need surgery. This study aims to provide contemporary data on prenatally diagnosed fetal abdominal cysts in relation to their course and postnatal outcomes. Methods Fetal abdominal cysts diagnosed over 11 years in a single centre were identified. Read More

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http://dx.doi.org/10.1515/jpm-2018-0311DOI Listing
February 2019

Interethnic Bias in Willingness to Engage in Casual Sex Versus Committed Relationships.

Authors:
Keon West

J Sex Res 2019 Feb 14:1-12. Epub 2019 Feb 14.

a Goldsmiths, University of London.

Interethnic romantic relationships are widely seen as a strong indicator of a well-integrated society. However, racial bias may still be evident in the tendency to engage in casual sex versus committed relationships. Using a large, age-diverse sample of 3,453 White British participants, this study found a general preference for White partners over racial minority partners. Read More

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http://dx.doi.org/10.1080/00224499.2018.1546372DOI Listing
February 2019

Are Limb-sparing Surgical Resections Comparable to Amputation for Patients With Pelvic Chondrosarcoma? A Case-control, Propensity Score-matched Analysis of the National Cancer Database.

Clin Orthop Relat Res 2019 Mar;477(3):596-605

Chang-Yeon Kim MD, MS, Christopher D. Collier MD, Raymond W. Liu MD, Patrick J. Getty MD, Department of Orthopaedics, University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH, USA.

Background: Chondrosarcoma is the second most frequent primary sarcoma of bone and frequently occurs in the pelvis. Surgical resection is the primary treatment with the two main operative modalities being limb-sparing resection and amputation. Contemporary management has trended toward limb-sparing procedures; however, whether this approach has an adverse effect on long-term survival is unclear. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000622DOI Listing

Sex differences in upper tract urothelial carcinomas.

Curr Opin Urol 2019 Feb 11. Epub 2019 Feb 11.

Nirmish Singla and Rashed A. Ghandour contributed equally to the article.

Purpose Of Review: To evaluate contemporary sex-specific differences in upper tract urothelial carcinoma (UTUC) by reviewing diagnostic considerations, clinicopathologic features, oncologic outcomes, environmental exposures, and regional variation in UTUC by sex.

Recent Findings: Although some contemporary studies implicate sex-based differences in UTUC, the literature concerning the effect of sex on clinicopathologic features and oncologic outcomes in UTUC reveals mixed findings. Factors accounting for the time to diagnosis in UTUC seem to differ between men and women. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000596DOI Listing
February 2019

Contemporary management of hepatoblastoma.

Curr Opin Organ Transplant 2019 Feb 11. Epub 2019 Feb 11.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Purpose Of Review: Hepatoblastoma is the most common primary pediatric liver malignancy. The goal of treatment in hepatoblastoma is complete surgical resection. Recently published multinational collaborative studies are better defining risk factors for disease recurrence and guide optimal treatment strategy. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000618DOI Listing
February 2019

Impact of unprotected left main percutaneous coronary intervention on long-term clinical outcomes: a large single-center study.

Coron Artery Dis 2019 Feb 11. Epub 2019 Feb 11.

Background: With the advancements of percutaneous coronary interventions (PCI), it is not clear whether unprotected left main (ULM) coronary artery disease (CAD) remains an independent predictor of adverse outcomes after PCI therapy. We have therefore carried out a large cohort study to investigate the impact of ULM disease on 2-year clinical outcomes in Chinese patients undergoing contemporary PCI treatment.

Methods And Results: From January 2013 to December 2013, 10 724 consecutive patients undergoing PCI were prospectively collected. Read More

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http://dx.doi.org/10.1097/MCA.0000000000000725DOI Listing
February 2019
2 Reads

Renal Artery Denervation for Hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 14;21(2). Epub 2019 Feb 14.

Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.

Purpose Of Review: Hypertension (HTN) has a growing impact, already affecting over 1 billion people. An estimated 2-16% of those with HTN have resistant HTN. The sympathetic nervous system (SNS) is a recognized contributor to the pathophysiology of resistant HTN. Read More

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http://dx.doi.org/10.1007/s11936-019-0715-6DOI Listing
February 2019

Contemporary practice of CRT implantation in Scandinavia compared to Europe.

Scand Cardiovasc J 2019 Feb 14:1-15. Epub 2019 Feb 14.

f Department of Cardiology , The Heart Centre , Rigshospitalet , University of Copenhagen , Copenhagen , Denmark.

Objectives: To compare the contemporary practice of CRT implantation in Scandinavia and Europe.

Design: We used data from The European CRT Survey II to highlight similarities and differences in the practice of CRT implantation between Europe (EUR) and Scandinavia (SCAND) and between the Scandinavian countries Denmark, Norway and Sweden. Implant data from the national pacemaker registries were used to calculate coverage. Read More

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http://dx.doi.org/10.1080/14017431.2019.1583364DOI Listing
February 2019

Coarctation of Aorta in Children.

Cureus 2018 Dec 5;10(12):e3690. Epub 2018 Dec 5.

Pediatric Cardiology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, USA.

Coarctation of aorta (CoA) is a discrete narrowing in aorta causing obstruction to the flow of blood. It accounts for 6-8% of all congenital heart diseases. With advances in fetal echocardiography rate of prenatal diagnosis of coarctation of aorta has improved but it still remains a challenging diagnosis to make prenatally. Read More

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http://dx.doi.org/10.7759/cureus.3690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368362PMC
December 2018

A Controlled Human Infection Model of Group A Pharyngitis: Which Strain and Why?

mSphere 2019 Feb 13;4(1). Epub 2019 Feb 13.

Tropical Diseases, Murdoch Children's Research Institute, Melbourne, Victoria, Australia

Group A (GAS) is a major cause of global infection-related morbidity and mortality. A modern controlled human infection model (CHIM) of GAS pharyngitis can accelerate vaccine development and pathogenesis research. A robust rationale for strain selection is central to meeting ethical, scientific, and regulatory requirements. Read More

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http://dx.doi.org/10.1128/mSphere.00647-18DOI Listing
February 2019

Development of a standardized Sanger-based method for partial sequencing and genotyping dengue viruses.

J Clin Microbiol 2019 Feb 13. Epub 2019 Feb 13.

Centers for Disease Control and Prevention, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector Borne Diseases, Dengue Branch, San Juan, PR

The global expansion of dengue viruses (DENV-1-4) has contributed to the divergence, transmission, and establishment of genetic lineages of epidemiological concern; however, tracking phylogenetic relationships of these virus is not always possible due to inability of standardized sequencing procedures in resource-limited public health laboratories Consequently, public genomic data banks contain inadequate representation of geographical regions and historical periods. In order to improve detection of DENV-1-4 lineages, we report the development of a serotype-specific Sanger-based method standardized to sequence DENV-1-4 directly from clinical samples using universal primers that detect most DENV genotypes. The resulting envelope protein coding sequences are analyzed for genotyping with phylogenetic methods. Read More

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http://dx.doi.org/10.1128/JCM.01957-18DOI Listing
February 2019

Impact of Discharge Location After Transcatheter Aortic Valve Replacement on 1-Year Outcomes in Women: Results From the WIN-TAVI Registry.

Can J Cardiol 2019 Feb 12;35(2):199-207. Epub 2018 Dec 12.

Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Background: Several clinical and procedural factors determine outcomes after transcatheter aortic valve replacement (TAVR), but data are scarce on the impact of post-TAVR discharge disposition on long-term outcomes. We sought to analyse whether discharge location after TAVR is associated with 1-year outcomes in women undergoing contemporary TAVR.

Methods: The Women's INternational Transcatheter Aortic Valve Implantation (WIN-TAVI) registry is the first all-female TAVR registry to study the safety and performance of contemporary TAVR in women (n = 1019). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.035DOI Listing
February 2019

Beyond Willpower: Strategies for Reducing Failures of Self-Control.

Psychol Sci Public Interest 2018 Dec;19(3):102-129

3 Department of Economics, Harvard University.

Almost everyone struggles to act in their individual and collective best interests, particularly when doing so requires forgoing a more immediately enjoyable alternative. Other than exhorting decision makers to "do the right thing," what can policymakers do to reduce overeating, undersaving, procrastination, and other self-defeating behaviors that feel good now but generate larger delayed costs? In this review, we synthesize contemporary research on approaches to reducing failures of self-control. We distinguish between self-deployed and other-deployed strategies and, in addition, between situational and cognitive intervention targets. Read More

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http://dx.doi.org/10.1177/1529100618821893DOI Listing
December 2018
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Traveling health-promoting infrastructures: A meta-ethnographic analysis.

Health (London) 2019 Feb 13:1363459319829195. Epub 2019 Feb 13.

University of Copenhagen, Denmark.

In recent years, it has become increasingly important to understand the global circulation of healthcare innovations in nations' attempts to solve contemporary health challenges. This article is a systematic review and meta-ethnography-inspired analysis that explores the global circulation of health-related standards, protocols, procedures, and regulations, or what we term health-promoting infrastructures (HPIs). The notion of HPIs is defined as built networks that allow for the circulation of health expertise with the intention of promoting solutions that address global health problems. Read More

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http://dx.doi.org/10.1177/1363459319829195DOI Listing
February 2019

Letter to Editor on "Maxi-PCNL": a contemporary evaluation of complications. (END-2018-0502-OR.R1 and J Endourol. 2018 Nov 6. doi: 10.1089/end.2018.0856).

J Endourol 2019 Feb 14. Epub 2019 Feb 14.

Universita Campus Bio-Medico di Roma, 9317, Roma, Lazio, Italy ;

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http://dx.doi.org/10.1089/end.2019.0005DOI Listing
February 2019

Evaluating contemporary pain management practices in thyroid and parathyroid surgery: A national survey of head and neck endocrine surgeons.

Head Neck 2019 Feb 13. Epub 2019 Feb 13.

Department of Otolaryngology - Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon.

Background: There is currently a lack of evidence-based guidelines regarding postoperative opioids after thyroid and parathyroid surgery. This study aimed to objectively characterize contemporary postoperative pain management practices via a national survey of head and neck endocrine surgeons.

Methods: A standardized electronic survey was distributed to the membership of the American Head and Neck Society's Endocrine section. Read More

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http://dx.doi.org/10.1002/hed.25694DOI Listing
February 2019
2.641 Impact Factor

Central role of obesity in endothelial cell dysfunction and cardiovascular risk.

Rev Assoc Med Bras (1992) 2019 Jan;65(1):87-97

. Laboratory of Vascular Biology and Atherosclerosis, Department of Internal Medicine, State University of Campinas (Unicamp), Campinas, SP, Brasil.

Atherosclerosis is the leading cause of mortality in the contemporary world. The critical role of the endothelial cells (EC) in vascular homeostasis, the metabolic changes that take place when the cell is activated, and the elements involved in these processes have been widely explored over the past years. Obesity and its impact, promoting a rise in blood levels of free fatty acids (FAs) are often associated with atherosclerosis and cardiovascular mortality. Read More

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http://dx.doi.org/10.1590/1806-9282.65.1.87DOI Listing
January 2019

Spatial and Compositional Biases Introduced by Position Sensitive Detection Systems in APT: A Simulation Approach.

Microsc Microanal 2019 Feb 13:1-7. Epub 2019 Feb 13.

Normandie Université, UNIROUEN, INSA Rouen, CNRS, Groupe de Physique des Matériaux,76000 Rouen,France.

Due to the low capacity of contemporary position-sensitive detectors in atom probe tomography (APT) to detect multiple events, material analyses that exhibit high numbers of multiple events are the most subject to compositional biases. To solve this limitation, some researchers have developed statistical correction algorithms. However, those algorithms are only efficient when one is confronted with homogeneous materials having nearly the same evaporation field between elements. Read More

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http://dx.doi.org/10.1017/S143192761801629XDOI Listing
February 2019

La Grippe or Russian influenza: Mortality statistics during the 1890 Epidemic in Indiana.

Authors:
E Thomas Ewing

Influenza Other Respir Viruses 2019 Feb 12. Epub 2019 Feb 12.

Department of History, Virginia Tech, Blacksburg, Virginia.

Background: The Russian influenza, which began in late 1889, has long been recognized as a major global epidemic yet available statistical evidence for morbidity and mortality has not been fully examined using historical and epidemiological tools. This study of cases and deaths in Indiana during the extended time period associated with the Russian influenza is the first scholarly effort to determine the number of victims from this influenza outbreak across a broad regional case study in the US.

Methods: The sources for this study include historical records from the US Census, Annual Reports from the Indiana State Board of Health, and death notices published in newspapers. Read More

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http://dx.doi.org/10.1111/irv.12632DOI Listing
February 2019

Looking forward: Disasters at 40.

Disasters 2019 Feb 12. Epub 2019 Feb 12.

Professor in Migration and Refugee Studies, University College London (UCL), United Kingdom.

This paper reflects on contemporary studies of and responses to disasters, highlighting the importance of historical, spatial, and intersectional modes of analysis, and draws on the author's ongoing research on Southern-led and local community responses to displacement in the Middle East. Acknowledging the plurality of 'international communities of response', it begins by critiquing the depiction of selected responses to disasters as 'positive' 'paradigm shifts', including in reference to the 'localisation of aid, and the United Nations' Regional Refugee and Resilience Plan for Syria. Next it turns to three key themes that are central to disasters studies: migration; forced displacement; and Southern-led responses to disasters. Read More

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http://dx.doi.org/10.1111/disa.12327DOI Listing
February 2019

The role of melatonin in targeting cell signaling pathways in neurodegeneration.

Ann N Y Acad Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Cellular and Structural Biology, University of Texas Health Science Center San Antonio, San Antonio, Texas.

Neurodegenerative diseases are typified by neuronal loss associated with progressive dysfunction and clinical presentation. Neurodegenerative diseases are characterized by the intra- and extracellular conglomeration of misfolded proteins that occur because of abnormal protein dynamics and genetic manipulations; these trigger processes of cell death in these disorders. The disrupted signaling mechanisms involved are oxidative stress-mediated mitochondrial and calcium signaling deregulation, alterations in immune and inflammatory signaling, disruption of autophagic integrity, proteostasis dysfunction, and anomalies in the insulin, Notch, and Wnt/β-catenin signaling pathways. Read More

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http://dx.doi.org/10.1111/nyas.14005DOI Listing
February 2019

Recent advances in understanding the role of the basal ganglia.

F1000Res 2019 30;8. Epub 2019 Jan 30.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

The basal ganglia are a complex subcortical structure that is principally involved in the selection and implementation of purposeful actions in response to external and internal cues. The basal ganglia set the pattern for facilitation of voluntary movements and simultaneous inhibition of competing or interfering movements. In addition, the basal ganglia are involved in the control of a wide variety of non-motor behaviors, spanning emotions, language, decision making, procedural learning, and working memory. Read More

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https://f1000research.com/articles/8-122/v1
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http://dx.doi.org/10.12688/f1000research.16524.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354324PMC
January 2019
1 Read

Contemporary climatic analogs for 540 North American urban areas in the late 21st century.

Nat Commun 2019 Feb 12;10(1):614. Epub 2019 Feb 12.

Department of Applied Ecology, Campus Box 7617, North Carolina State University Campus, Raleigh, NC, 27695, USA.

A major challenge in articulating human dimensions of climate change lies in translating global climate forecasts into impact assessments that are intuitive to the public. Climate-analog mapping involves matching the expected future climate at a location (e.g. Read More

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http://www.nature.com/articles/s41467-019-08540-3
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http://dx.doi.org/10.1038/s41467-019-08540-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372656PMC
February 2019
2 Reads

Contemporary management of cardiac implantable electronic device infection.

Heart 2019 Feb 12. Epub 2019 Feb 12.

Department of Cardiovascular Diseases, Mayo Clinic Arizona, Phoenix, Arizona, USA.

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2017-312146
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http://dx.doi.org/10.1136/heartjnl-2017-312146DOI Listing
February 2019
1 Read

Hip fracture care in Manitoba, Canada and New York State, United States: an analysis of administrative data.

CMAJ Open 2019 Jan-Mar;7(1):E55-E62. Epub 2019 Feb 11.

North American Observatory on Health Systems and Policies (Cram), Institute for Health Policy, Management and Evaluation, University of Toronto; Departments of Medicine (Cram) and Surgery (Gandhi), University of Toronto; Division of General Internal Medicine and Geriatrics (Cram), Sinai Health System and University Health Network, Toronto, Ont.; Departments of Community Health Sciences (Lix, Bohm, Yan, Roos), Surgery (Bohm) and Medicine (Leslie), University of Manitoba, Winnipeg, Man.; Biostatistics Research Unit (Matelski) and Arthritis Program (Gandhi), University Health Network, Toronto, Ont.; Department of Health Care Policy (Landon), Harvard Medical School; Division of General Medicine and Primary Care (Landon), Beth Israel Deaconess Medical Center, Boston, Mass.

Background: Nearly 30 years ago, a series of studies showed increased hip fracture mortality in Manitoba compared to the United States, but these data have not been updated. Our objective was to compare the organization of hip fracture care and short-term outcomes in Manitoba and New York State using contemporary data.

Methods: This was a retrospective cohort study of administrative data for all adults aged 50 years or more admitted to hospital with hip fracture between Jan. Read More

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http://dx.doi.org/10.9778/cmajo.20180126DOI Listing
February 2019