Synthesis, Antifungal Activity, and Biocompatibility of novel DABCO Compounds and DABCO- containing Denture Base Resins.
- Jenny L Herman,
- Yapin Wang,
- Elizabeth Lilly,
- Thomas Lallier,
- Suleiman Hamdan,
- Xiaoming Xu,
- Paul L Fidel,
- Mairi C Noverr
Antimicrob Agents Chemother 2017 Jan 23. Epub 2017 Jan 23.
Department of Periodontics, Department of Comprehensive Dentistry and Biomaterials, Department of Oral Biology, Department of Anatomy and Cell Biology, or Department of Prosthodontics, Louisiana State University Health Sciences Center, New Orleans, LA 70119
The fungal pathogen Candida albicans causes a variety of oral infections including denture stomatitis, which is characterized by inflammation of the oral mucosa in direct contact with dentures, and affects a significant number of otherwise healthy denture wearers. While antifungal treatment reduces symptoms, infections are often recurrent. One strategy to address this problem is to incorporate compounds with fungicidal activities into denture materials to prevent colonization. Read More