693 results match your criteria Contact Stomatitis


In Vitro Assessment of Artificial Aging on the Antifungal Activity of PMMA Denture Base Material Modified with ZrO Nanoparticles.

Int J Dent 2021 13;2021:5560443. Epub 2021 May 13.

Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 41441, Saudi Arabia.

The antifungal effect of zirconium dioxide nanoparticles (ZrONPs) incorporated into denture base material has been inadequately investigated; additionally, to the authors' knowledge, no studies have assessed the influence of artificial aging on the antifungal activity of these particles. . Heat-polymerized acrylic resin disks were fabricated and divided into four groups (0%, 1%, 2. Read More

View Article and Full-Text PDF

Histopathologic Spectrum of Intraoral Irritant and Contact Hypersensitivity Reactions: A Series of 12 cases.

Head Neck Pathol 2021 Apr 26. Epub 2021 Apr 26.

Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, 02115, USA.

Background: Irritant contact stomatitis (ICS) and contact hypersensitivity stomatitis (CHS) are often caused by alcohol, flavoring agents and additives in dentifrices and foods, and contactants with high or low pH. A well-recognized contactant for ICS is Listerine™ mouthwash, while that for CHS is cinnamic aldehyde. However, many other flavoring agents and even smokeless tobacco are contactants that cause mucosal lesions that are entirely reversible. Read More

View Article and Full-Text PDF

Recurrent Aphthous Stomatitis Improved after Eradication Therapy for .

Case Rep Gastrointest Med 2021 30;2021:5543838. Epub 2021 Mar 30.

Gastroenterology Department, Loma Linda University Medical Center, Loma Linda, CA, USA.

(. ) is a Gram-negative bacterium that colonizes gastric mucosa and is often transmitted through direct contact with saliva, contaminated food or water, and vomit. The majority of the infected individuals remain asymptomatic for a long period. Read More

View Article and Full-Text PDF

High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission.

Emerg Microbes Infect 2021 Dec;10(1):651-663

Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

The recent impact of Ebola virus disease (EVD) on public health in Africa clearly demonstrates the need for a safe and efficacious vaccine to control outbreaks and mitigate its threat to global health. ERVEBO® is an effective recombinant Vesicular Stomatitis Virus (VSV)-vectored Ebola virus vaccine (VSV-EBOV) that was approved by the FDA and EMA in late 2019 for use in prevention of EVD. Since the parental virus VSV, which was used to construct VSV-EBOV, is pathogenic for livestock and the vaccine virus may be shed at low levels by vaccinated humans, widespread deployment of the vaccine requires investigation into its infectivity and transmissibility in VSV-susceptible livestock species. Read More

View Article and Full-Text PDF
December 2021

Antifungal property of acrylic denture soft liner containing silver nanoparticles synthesized in situ.

J Dent 2021 03 29;106:103589. Epub 2021 Jan 29.

Department of Prosthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address:

Objectives: Denture soft liner is applied to relieve pain from candida-induced denture stomatitis and promote healing, but with shortage of antifungal activity and easily harbors fungi. To overcome this problem, the in-situ method was used to synthesize silver nanoparticles (AgNPs) in acrylic soft liner to obtain antifungal effects.

Methods: Acrylic soft-liner with various weight percentage of silver 2-ethylhexanoate (0%, 0. Read More

View Article and Full-Text PDF

Effect of Denture Base Fabrication Technique on Adhesion In Vitro.

Materials (Basel) 2021 Jan 5;14(1). Epub 2021 Jan 5.

Department of Prosthodontics, Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv 69978, Israel.

Denture stomatitis is a common manifestation of oral candidiasis affecting some 65% of denture wearers. This condition is initiated by the adherence of to denture base acrylic resin. The present study aimed to test the in vitro effect of traditional and novel fabrication methods on adhesion to denture base samples. Read More

View Article and Full-Text PDF
January 2021

Comparison of patients' diagnoses in a dermatology outpatient clinic during the COVID-19 pandemic period and pre-pandemic period.

Int J Clin Pract 2021 Apr 26;75(4):e13948. Epub 2020 Dec 26.

Department of Biostatistics and Medical Informatics, Medical Faculty, Inonu University, Malatya, Turkey.

Aim: In this study, we compared the current diagnoses of patients admitted to the dermatology outpatient clinic with the diagnoses during the non-pandemic period, and we examined the effect of COVID-19 on the patient profile.

Methods: Diagnoses were compared by examining the patient files of the 3-month period when the pandemic was influential in our country and the 2-week non-pandemic period corresponding to the same season a year ago. The outpatient diagnoses in the first month and the last month of the 3-month pandemic period were also compared. Read More

View Article and Full-Text PDF

Antifungal and Surface Properties of Chitosan-Salts Modified PMMA Denture Base Material.

Molecules 2020 Dec 13;25(24). Epub 2020 Dec 13.

Department of Experimental Dentistry, Faculty of Dentistry, Wroclaw Medical University, 26 Krakowska st., 50-425 Wroclaw, Poland.

Chitosan (CS) and its derivatives show antimicrobial properties. This is of interest in preventing and treating denture stomatitis, which can be caused by fungi. Therefore, the aim of this study was the development of a novel antifungal denture base material by modifying polymethyl methacrylate (PMMA) with CS-salt and characterizing its antifungal and surface properties in vitro. Read More

View Article and Full-Text PDF
December 2020

Allergic Contact Cheilitis and Stomatitis Due to Triclosan in Toothpaste.

Authors:
Kalman L Watsky

Dermatitis 2021 Jan-Feb 01;32(1):e15-e16

From the Yale University School of Medicine, Yale-New Haven Hospital, CT.

View Article and Full-Text PDF
December 2020

Validation of a binary ethylenimine (BEI) inactivation procedure for biosafety treatment of foot-and-mouth disease viruses (FMDV), vesicular stomatitis viruses (VSV), and swine vesicular disease virus (SVDV).

Vet Microbiol 2021 Jan 16;252:108928. Epub 2020 Nov 16.

Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, United States Department of Agriculture, Plum Island Animal Disease Center, 40550 Route 25, Orient Point, NY 11957, USA. Electronic address:

Binary ethylenimine (BEI) has been widely used as a virucide to inactivate viruses. For regulatory exclusion of a select agent, the United States Federal Select Agent Program (FSAP) requires an inactivation procedure that renders a select agent non-viable but allows the select agent to retain antigenic characteristics for future use must be validated, and the inactivated agent must be confirmed by a viability testing. In this curve-based validation study, we examined impacts of BEI concentration, treatment temperature, and time on our in-house inactivation procedures of Foot-and-Mouth Disease Virus (FMDV), Vesicular Stomatitis Virus (VSV), and Swine Vesicular Disease Virus (SVDV). Read More

View Article and Full-Text PDF
January 2021

Development of Spray Formulations Applied to the Oral Mucosa Using Non-lamellar Liquid Crystal-Forming Lipids.

Chem Pharm Bull (Tokyo) 2020 ;68(11):1025-1033

Faculty of Pharmacy and Pharmaceutical Sciences, Josai University.

We examined the physicochemical and biochemical properties of mono-O-(5,9,13-trimethyl-4-tetradecenyl)glycerol ester (MGE), including ease of handling, high bioadhesiveness, quick and stable in vivo self-organization (forming a non-lamellar lyotropic liquid crystal [NLLC]), and high biomembrane permeation enhancement. We prepared MGE oral mucosa-applied spray preparations containing triamcinolone acetonide (TA), which is widely used in the treatment of stomatitis, and we examined the usefulness of the MGE preparations compared with commercially available oral mucosal application preparations containing 2,3-dihydroxypropyl oleate (1-mono(cis-9-octadecenoyl)glycerol (GMO) (previously studied as an NLLC-forming lipid) preparation. As a result, the MGE preparation applied to the oral mucosa can rapidly formed an NLLC with reverse hexagonal or cubic structures, or a mixture, on contact with water. Read More

View Article and Full-Text PDF

Modelling the daily risk of Ebola in the presence and absence of a potential vaccine.

Infect Dis Model 2020 15;5:905-917. Epub 2020 Oct 15.

Department of Mathematics and Faculty of Medicine, The University of Ottawa, 150 Louis-Pasteur Pvt, Ottawa, ON, K1N6N5, Canada.

Ebola virus - one of the deadliest viral diseases, with a mortality rate around 90% - damages the immune system and organs, with symptoms including episodic fever, chills, malaise and myalgia. The Recombinant Vesicular Stomatitis Virus-based candidate vaccine (rVSV-ZEBOV) has demonstrated clinical efficacy against Ebola in ring-vaccination clinical trials. In order to evaluate the potential effect of this candidate vaccine, we developed risk equations for the daily risk of Ebola infection both currently and after vaccination. Read More

View Article and Full-Text PDF
October 2020

Oral Hypersensitivity Reactions.

Dermatol Clin 2020 Oct 11;38(4):467-476. Epub 2020 Aug 11.

Department of Dermatology, University of Pennsylvania, 822 Pine Street Suite 2A, Philadelphia, PA 19107, USA.

Allergic contact hypersensitivity reactions of the oral mucosa pose a significant medical concern for some patients. Oral hypersensitivity reactions can result from a vast number of allergenic chemicals, but occur commonly from dental materials, flavorings, and preservatives. Clinical presentation is varied and often overlaps with other oral conditions, complicating their diagnosis and management. Read More

View Article and Full-Text PDF
October 2020

[Medicaments and oral healthcare. Adverse effects of medications on the oral mucosa].

Ned Tijdschr Tandheelkd 2020 Jul-Aug;127(7-08):434-440

Many medications prescribed in the Netherlands have adverse effects on the oral mucosa. Adverse events often described are stomatitis, white lesions, abnormal pigmentation and sensibility disorders. Stomatitis is frequently observed in patients using medications for the treatment of malignancies or auto-immune diseases. Read More

View Article and Full-Text PDF

Oral Vaccination With Recombinant Vesicular Stomatitis Virus Expressing Sin Nombre Virus Glycoprotein Prevents Sin Nombre Virus Transmission in Deer Mice.

Front Cell Infect Microbiol 2020 8;10:333. Epub 2020 Jul 8.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

Sin Nombre virus (SNV) is the major cause of hantavirus cardiopulmonary syndrome (HCPS) in North America, a severe respiratory disease with a high fatality rate. SNV is carried by , or deer mice, and human infection occurs following inhalation of aerosolized virus in mouse excreta or secreta, often in peri-domestic settings. Currently there are no FDA approved vaccines or therapeutics for SNV or any other hantaviruses, therefore prevention of infection is an important means of reducing the disease burden of HCPS. Read More

View Article and Full-Text PDF

Assessing the ocular surface microbiome in severe ocular surface diseases.

Ocul Surf 2020 10 24;18(4):706-712. Epub 2020 Jul 24.

Department of Ophthalmology, Loyola University Medical Center, USA. Electronic address:

Purpose: There is growing evidence for a critical role of the microbiome in ocular health and disease. We performed a prospective, observational study to characterize the ocular surface microbiome (OSM) in four chronic ocular surface diseases (OSDs) and healthy controls.

Methods: Sterile swabs were used to collect samples from each eye of 39 patients (78 eyes). Read More

View Article and Full-Text PDF
October 2020

Critical Residues and Contacts within Domain IV of Autographa californica Multiple Nucleopolyhedrovirus GP64 Contribute to Its Refolding during Membrane Fusion.

J Virol 2020 09 15;94(19). Epub 2020 Sep 15.

State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Northwest Loess Plateau Crop Pest Management of Ministry of Agriculture, College of Plant Protection, Northwest A&F University, Yangling, China

Autographa californica multiple nucleopolyhedrovirus (AcMNPV) GP64 is a class III viral fusion protein that mediates low-pH-triggered membrane fusion during virus entry. Although the structure of GP64 in a postfusion conformation has been solved, its prefusion structure and the mechanism of how the protein refolds to execute fusion are unknown. In its postfusion structure, GP64 is composed of five domains (domains I to V). Read More

View Article and Full-Text PDF
September 2020

Lid-Related Keratopathy in Stevens-Johnson Syndrome: Natural Course and Impact of Therapeutic Interventions in Children and Adults.

Am J Ophthalmol 2020 11 15;219:357-365. Epub 2020 Jul 15.

The Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India; Brien Holden Eye Research Centre (BHERC), L V Prasad Eye Institute, Hyderabad, Telangana, India. Electronic address:

Purpose: To compare the long-term visual outcomes of different management strategies in children and adults with Stevens-Johnson Syndrome (SJS)-induced chronic lid-related keratopathy.

Design: Retrospective comparative case series.

Methods: This study included 705 eyes of 401 patients (81 children and 320 adults) with SJS who presented with chronic lid-related keratopathy between 1990 and 2015. Read More

View Article and Full-Text PDF
November 2020

Impact of pyriproxyfen on virus behavior: implications for pesticide-induced virulence and mechanism of transmission.

Virol J 2020 07 6;17(1):93. Epub 2020 Jul 6.

Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, 3400 Gulf to Bay Blvd, Clearwater, FL, 33759, USA.

Background: More than 3 years since the last Zika virus (ZIKV) outbreak in Brazil, researchers are still deciphering the molecular mechanisms of neurovirulence and vertical transmission, as well as the best way to control spread of ZIKV, a flavivirus. The use of pesticides was the main strategy of mosquito control during the last ZIKV outbreak.

Methods: We used vesicular stomatitis virus (VSV) tagged with green fluorescent protein (GFP) as our prototypical virus to study the impact of insecticide pyriproxyfen (PPF). Read More

View Article and Full-Text PDF

Antimicrobial and protective effects of non-thermal plasma treatments on the performance of a resinous liner.

Arch Oral Biol 2020 Sep 20;117:104822. Epub 2020 Jun 20.

Department of Prosthodontics and Periodontology, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil. Electronic address:

Objective: Overcoming substantial shortcomings of soft liners as physico-chemical changes and liner-biofilm-related infections remains a challenge in the rehabilitation treatment. In this study, protective non-thermal plasma (NTP) treatments were developed on the soft liner surface to improve its surface and physico-chemical properties and to reduce fungal colonization after biofilm inhibition challenge.

Methods: Resinous liner specimens (Coe-Soft) were prepared and distributed in 3 groups according to the surface treatments: (1) untreated (control); (2) treated with sulfur hexafluoride-based NTP (SF); and (3) treated with hexamethyldisiloxane-based NTP (HMDSO). Read More

View Article and Full-Text PDF
September 2020

A Single Amino Acid Substitution in the Matrix Protein (M51R) of Vesicular Stomatitis New Jersey Virus Impairs Replication in Cultured Porcine Macrophages and Results in Significant Attenuation in Pigs.

Front Microbiol 2020 29;11:1123. Epub 2020 May 29.

Foreign Animal Disease Research Unit, USDA/ARS Plum Island Animal Disease Center, Greenport, NY, United States.

In this study, we explore the virulence of vesicular stomatitis New Jersey virus (VSNJV) in pigs and its potential relationship with the virus's ability to modulate innate responses. For this purpose, we developed a mutant of the highly virulent strain NJ0612NME6, containing a single amino acid substitution in the matrix protein (M51R). The M51R mutant of NJ0612NME6 was unable to suppress the transcription of genes associated with the innate immune response both in primary fetal porcine kidney cells and porcine primary macrophage cultures. Read More

View Article and Full-Text PDF

Assessing the Contributions of Inactivation, Removal, and Transfer of Ebola Virus and Vesicular Stomatitis Virus by Disinfectant Pre-soaked Wipes.

Front Public Health 2020 2;8:183. Epub 2020 Jun 2.

Reckitt Benckiser LLC, Global Research & Development for Lysol and Dettol, Montvale, NJ, United States.

Disinfectant pre-soaked wipes (DPW) containing activated hydrogen peroxide (AHP) or quaternary ammonium compounds (QAC) were tested using ASTM E2967-15 to determine removal, transfer, and inactivation of Ebola virus Makona variant (EBOV/Mak) and vesicular stomatitis virus (VSV) from contaminated stainless steel prototypic environmental surfaces. The infectious virus-contaminated carriers were subjected to wiping in the Wiperator per the standard. Following the use of negative control (J-Cloth)-, AHP-, or QAC-based wipes, recovery of residual infectious virus was assayed. Read More

View Article and Full-Text PDF

Oral changes associated with kolanut use: a report of 2 cases.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jul 14;130(1):e5-e9. Epub 2020 May 14.

Associate Professor, Faculty of Dentistry, King Abdul-Aziz University, Jeddah, Saudi Arabia. Electronic address:

Introduction: Contact stomatitis (CS) is an inflammatory reaction of the oral mucosa induced by contact with an irritant, such as menthol and cinnamon compounds. We are reporting 2 cases of CS related to the use of kolanut, a caffeine-containing nut of evergreen trees.

Case Description: Case 1 was a 22-year-old man with history of chewing kolanut for the past 10 years; he presented with a grayish-white, velvety, leukoplakia-like plaque with ill-defined borders in the mandibular anterior facial vestibule and extending to the lower labial mucosa. Read More

View Article and Full-Text PDF

Detection of Two Species of the Genus Parapoxvirus (Bovine Papular Stomatitis Virus and Pseudocowpox Virus) in Ticks Infesting Cattle in Burkina Faso.

Microorganisms 2020 Apr 28;8(5). Epub 2020 Apr 28.

Laboratory of Parasitology and Parasitic Diseases, Center for Fundamental and Applied Research for Animal and Health (FARAH), Faculty of Veterinary Medicine, ULiège, 4000 Liège, Belgium.

The molecular identification of arboviruses in West Africa is of particular interest, due to their zoonotic potential in a population living in close contact with livestock, and in a region where the livestock migration across borders raises the risk of diseases infection and dissemination. The aim of the study was the screening of potential circulating arboviruses and the assessment of their zoonotic implications. Therefore, ticks were collected on cattle located in three provinces of eastern Burkina Faso. Read More

View Article and Full-Text PDF

A Case Report on Stomatitis Venenata Due to the Use of Lip Balm.

Med Arch 2020 Feb;74(1):65-68

Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram, Chennai, India.

Introduction: Allergic reactions can manifest in various forms ranging from mild, almost unnoticeable reactions to life threatening anaphylaxis. Stomatitis venenata or contact stomatitis is described as a contact allergy of the oral mucosa which can occur due to repeated contact with the causative agent. Dental and cosmetic products, dental materials and dental therapeutic agents are the common allergens of the oral cavity. Read More

View Article and Full-Text PDF
February 2020

Lumpy skin disease (LSD) outbreaks in cattle in Odisha state, India in August 2019: Epidemiological features and molecular studies.

Transbound Emerg Dis 2020 Nov 5;67(6):2408-2422. Epub 2020 May 5.

ICAR-National Institute of High Security Animal Diseases, Bhopal, Madhya Pradesh, India.

Lumpy skin disease (LSD) caused by lumpy skin disease virus (LSDV) inflicts significant economic losses in cattle production with impact on livelihoods of smallholders. This study reports the first occurrence of LSD in cattle in India and analyses epidemiological and genetic characterization data from LSD outbreaks in five districts of Odisha state in August 2019. In all, 182 of 2,539 cattle were affected with an apparent morbidity rate of 7. Read More

View Article and Full-Text PDF
November 2020

Mucoadhesive in situ forming gel for oral mucositis pain control.

Int J Pharm 2020 Apr 16;580:119238. Epub 2020 Mar 16.

Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States.

The current first line therapy for oral mucositis pain control is unsatisfactory as it results in only a short duration of modest pain relief. Developing mucoadhesive in situ forming formulations to prolong pain relief is challenging due to their complex physicochemical properties and the unique requirements for oral mucosa application. The objective of this study is to develop a mucoadhesive in situ forming gel to deliver a novel drug molecule, Bupivacaine γ-linoleate (Bup-γL), for prolonged and more potent oral mucositis pain control. Read More

View Article and Full-Text PDF

Allergic contact stomatitis caused by propolis throat candies.

Contact Dermatitis 2020 Jul 1;83(1):58-59. Epub 2020 Apr 1.

Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China.

View Article and Full-Text PDF

Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials' resistance.

Bioact Mater 2020 Jun 21;5(2):228-232. Epub 2020 Feb 21.

Dental Materials Laboratory, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil.

To reduce the burden of denture stomatitis and oral candidiasis, an aqueous solution containing polyhexamethylene guanidine hydrochloride (PHMGH) was investigated as an antifungal disinfectant against the leading cause of these oral conditions, . The solutions formulated with concentrations ranging from 0.125 to 0. Read More

View Article and Full-Text PDF