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    1 OF 12

    Quantification of l-carvone in toothpastes available on the Swedish market.
    Contact Dermatitis 2017 May 19. Epub 2017 May 19.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. Read More

    Oncolytic Recombinant Vesicular stomatitis virus (VSV) is nonpathogenic and non-transmissible in pigs, a natural host of VSV.
    Hum Gene Ther Clin Dev 2017 May 17. Epub 2017 May 17.
    Plum Island Animal Disease Center, 85727, United States Department of Agriculture - Agricultural Research Services, Greenport, New York, United States ;
    Vesicular stomatitis virus (VSV) is a negative-stranded RNA virus that naturally causes disease in livestock including horses, cattle and pigs. The two main identified VSV strains are the New Jersey (VSNJV) and Indiana (VSIV) strains. VSV is a rapidly replicating, potently immunogenic virus that has been engineered to develop novel oncolytic therapies for cancer treatment. Read More

    Benign reactive lymphadenopathy associated with submandibular gland enlargement during orthodontic treatment.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):181
    Department of Oral Pathology, Army College of Dental Sciences, Secunderabad, Telangana, India.
    Lymphadenopathy may be caused due to various reasons, most common being infections, neoplasms and immunologic disorders. Considering the frequent use of biomaterials in dentistry, it is not uncommon to find allergic reactions in the oral mucosa. Delayed-type hypersensitivity is one mechanism of allergy, which may manifest as either contact stomatitis or rarely present as only lymphadenopathy. Read More

    Effects of trimethylsilane plasma coating on the hydrophobicity of denture base resin and adhesion of Candida albicans on resin surfaces.
    J Prosthet Dent 2017 Apr 20. Epub 2017 Apr 20.
    Professor, Department of Mechanical & Aerospace Engineering, University of Missouri, Columbia, Mo.
    Statement Of Problem: Candida-associated denture stomatitis is the most common oral mucosal lesion among denture wearers. Trimethylsilane (TMS) plasma coating may inhibit the growth of Candida albicans on denture surfaces.

    Purpose: The purpose of this in vitro study was to investigate whether TMS plasma coatings can effectively reduce C albicans adhesion on denture base acrylic resin surfaces. Read More

    Review: allergic contact stomatitis.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 May 21;123(5):559-565. Epub 2017 Feb 21.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
    Allergic contact stomatitis (ACS) is an oral mucosal immunoinflammatory disorder variably characterized clinically by erythematous plaques, vesiculation, ulceration, and/or hyperkeratosis and by pain, burning sensation, or itchiness. ACS is brought about by a T cell-mediated, delayed hypersensitivity immune reaction generated by a second or subsequent contact exposure of an allergen with the oral mucosa, in a genetically susceptible, sensitized subject. Lichenoid contact reaction is a variant of ACS brought about by direct contact with the oral mucosa of certain metals in dental restorations. Read More

    Treatment of recurrent aphthous stomatitis with Er,Cr:YSGG laser irradiation: A randomized controlled split mouth clinical study.
    J Photochem Photobiol B 2017 Mar 22;170:1-5. Epub 2017 Mar 22.
    Department of Periodontology, Faculty of Dentistry, Near East University, Mersin, Turkey.
    The present randomized controlled split mouth clinical study aimed to investigate the efficacy of Er,Cr:YSGG laser irradiation on pain reduction and healing rate of recurrent aphthous stomatitis. 40 patients with RAS were recruited for this study and RAS ulcerations of each patient were randomly assigned to the control or test group. In the test group, Er,Cr:YSGG laser with non-contact mode was used to irradiate RAS lesions. Read More

    Contact Allergy to (Ingredients of) Toothpastes.
    Dermatitis 2017 Mar/Apr;28(2):95-114
    From acdegroot publishing, Wapserveen, The Netherlands.
    The literature on contact allergy to (ingredients of) toothpastes is critically reviewed. We have found 47 case reports, small case series (n = 2-5) and citations published between 1900 and 2016 describing more than 60 patients allergic to toothpastes, and in addition 3 larger case series and many descriptions of toothpaste allergy among selected groups of patients. Allergic reactions usually manifest as cheilitis with or without dermatitis around the mouth, less frequently by oral symptoms. Read More

    Allergic Stomatitis From Orthodontic Adhesives.
    Mil Med 2017 Mar;182(3):e1883-e1885
    Department of Allergy and Immunology, Wilford Hall Ambulatory Surgical Center, 2200 Bergquist Drive, Lackland Air Force Base, TX 78236.
    We report a case of a type IV hypersensitivity reaction causing oral stomatitis, presumed to be the result of common dental adhesives. The case was diagnosed using patch testing to the dental adhesives that were used in the patient. Both of the adhesives tested contained a form of acrylate that is being seen more frequently in the literature as a cause of type IV hypersensitivity reactions. Read More

    Synthesis, Antifungal Activity, and Biocompatibility of Novel 1,4-Diazabicyclo[2.2.2]Octane (DABCO) Compounds and DABCO-Containing Denture Base Resins.
    Antimicrob Agents Chemother 2017 Apr 24;61(4). Epub 2017 Mar 24.
    Department of Prosthodontics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    The fungal pathogen Candida albicans causes a variety of oral infections, including denture stomatitis, which is characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise healthy denture wearers. While antifungal treatment reduces symptoms, infections are often recurrent. One strategy to address this problem is to incorporate compounds with fungicidal activities into denture materials to prevent colonization. Read More

    Symptomatic oral lesions may be associated with contact allergy to substances in oral hygiene products.
    Clin Oral Investig 2017 Jan 13. Epub 2017 Jan 13.
    Section for Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, Faculty of Medical and Health Sciences, University of Copenhagen, 20 Noerre Allé, 2200, Copenhagen N, DK, Denmark.
    Objective: Dental materials and oral hygiene products may be responsible for oral contact allergic reactions. We aimed to determine the occurrence of allergies in patients with symptomatic oral lichen planus (OLP), oral lichenoid lesions (OLLs) and stomatitis and investigate if patch testing could identify contact allergies to dental materials and oral hygiene products in these patients.

    Methods: Forty-nine patients (7 men, 42 women) aged 31 to 77 years (61 ± 10. Read More

    Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls.
    J Eur Acad Dermatol Venereol 2017 May 9;31(5):887-893. Epub 2017 Jan 9.
    Department of Odontology, Oral Pathology and Oral Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.
    Background: Lichen planus (LP) is a chronic inflammatory disease of unknown aetiology affecting the skin and oral mucosa. Oral lichenoid lesions (OLLs), like oral contact reactions, may resemble oral lichen planus (OLP) both clinically and histopathologically. As OLP and OLL are hyperkeratotic diseases and filaggrin is essential to keratinization, the distribution of filaggrin may be altered in these lesions. Read More

    Mechanism of membrane fusion induced by vesicular stomatitis virus G protein.
    Proc Natl Acad Sci U S A 2017 Jan 14;114(1):E28-E36. Epub 2016 Dec 14.
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;
    The glycoproteins (G proteins) of vesicular stomatitis virus (VSV) and related rhabdoviruses (e.g., rabies virus) mediate both cell attachment and membrane fusion. Read More

    Beneficial Effects of Everolimus on Autism and Attention-Deficit/Hyperactivity Disorder Symptoms in a Group of Patients with Tuberous Sclerosis Complex.
    J Child Adolesc Psychopharmacol 2017 May 31;27(4):383-388. Epub 2016 Oct 31.
    2 Department of Child Neurology, Istanbul Faculty of Medicine, Istanbul University , Istanbul, Turkey .
    Objectives: Such neuropsychiatric symptoms as autism spectrum disorders, attention-deficit/hyperactivity disorder (ADHD), intellectual disability, aggression, and epilepsy are very common in patients with tuberous sclerosis complex (TSC). Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, is a recent and effective treatment for TSC patients with giant cell astrocytomas and renal angiomyolipoma, and it has been shown to have a potential to reduce tumor volume. However, there is a paucity of studies on the effects of everolimus on neuropsychiatric symptoms. Read More

    Intranasal Location and Immunohistochemical Characterization of the Equine Olfactory Epithelium.
    Front Neuroanat 2016 13;10:97. Epub 2016 Oct 13.
    Institute of Veterinary Pathology, Faculty of Veterinary Medicine, Justus Liebig University Giessen Giessen, Germany.
    The olfactory epithelium (OE) is the only body site where neurons contact directly the environment and are therefore exposed to a broad variation of substances and insults. It can serve as portal of entry for neurotropic viruses which spread via the olfactory pathway to the central nervous system. For horses, it has been proposed and concluded mainly from rodent studies that different viruses, e. Read More

    Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants.
    J Biol Regul Homeost Agents 2016 Jul-Sep;30(3):889-894
    Department of Surgical Sciences, Dental School, University of Turin, Turin, Italy.
    Oral mucositis (OM) may occur in up to 100% of patients undergoing condition regimen to hematopoietic stem cell transplant (HSCT). From the patient’s perspective, OM is one of the most debilitating side effects of transplantation. It is commonly thought that oral hygiene can modify the incidence and severity of oral mucositis, therefore professional oral health care (POHC) is recommended prior to conditioning regimen for HSCT. Read More

    Spatiotemporal dynamics of the Ebola epidemic in Guinea and implications for vaccination and disease elimination: a computational modeling analysis.
    BMC Med 2016 Sep 7;14(1):130. Epub 2016 Sep 7.
    Laboratory for the Modeling of Biological and Socio-technical Systems, Northeastern University, 360 Huntington Ave, Boston, MA, 02115, USA.
    Background: Among the three countries most affected by the Ebola virus disease outbreak in 2014-2015, Guinea presents an unusual spatiotemporal epidemic pattern, with several waves and a long tail in the decay of the epidemic incidence.

    Methods: Here, we develop a stochastic agent-based model at the level of a single household that integrates detailed data on Guinean demography, hospitals, Ebola treatment units, contact tracing, and safe burial interventions. The microsimulation-based model is used to assess the effect of each control strategy and the probability of elimination of the epidemic according to different intervention scenarios, including ring vaccination with the recombinant vesicular stomatitis virus-vectored vaccine. Read More

    Unmet diagnostic needs in contact oral mucosal allergies.
    Clin Mol Allergy 2016 1;14(1):10. Epub 2016 Sep 1.
    Section of Allergology and Clinical Immunology, Department of Internal Medicine and Infectious Diseases, University of Bari Medical School, Bari, Italy.
    The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the oral mucosa to irritant agents and allergens due to anatomical and physiological factors. The spectrum of signs and symptoms of oral contact allergies (OCA) is broad and a large number of condition can be the clinical expression of OCA such as allergic contact stomatitis, allergic contact cheilitis, geographic tongue, oral lichenoid reactions, burning mouth syndrome. Read More

    [Mucosal diseases from an allergological perspective].
    Hautarzt 2016 Oct;67(10):780-785
    Univ. Klinik für Dermatologie, LKH Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.
    The oral allergy syndrome is one of the most common form of food allergy and manifests as contact urticaria of the oral mucosa after consumption of cross reacting foods. Whereas allergic contact stomatitis often occurs due to dental materials, allergic contact cheilitis is usually a reaction due to topical therapeutics like herpes ointments or lip care products. As late type reactions are more frequent than immediate type reactions in the anogenital mucosa, contact dermatitis in this area should be identified via epicutaneous testing. Read More

    Effect of incorporating seed oils on the antifungal property, surface roughness, wettability, weight change, and glucose sorption of a soft liner.
    J Prosthet Dent 2017 Jan 1;117(1):178-185. Epub 2016 Aug 1.
    Professor, Department of Prosthodontics and Crown and Bridge and Implantology, Coorg Institute of Dental Sciences, Virajpet, Coorg, and Rajiv Gandhi University of Health Sciences, Bangalore, India.
    Statement Of Problem: The colonization of Candida albicans on soft liners causes the deterioration of material surface properties and denture stomatitis.

    Purpose: The purpose of this in vitro study was to investigate the effect of incorporating seed oil on the antifungal properties, surface roughness, wettability, weight changes, and glucose adsorption/absorption of a soft liner.

    Material And Methods: Centratherum anthelminticum, Ocimum sanctum Linn, and Linum usitatissimum seed oils were incorporated into a soft liner, and the diameter of the inhibition zone (DIZ) was calculated relative to the growth of C albicans at 24, 48, and 72 hours and 7 days. Read More

    Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during Candida albicans-Associated Denture Stomatitis.
    PLoS One 2016 25;11(7):e0159692. Epub 2016 Jul 25.
    Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America.
    Denture stomatitis (DS) is characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise healthy denture wearers. The disease is caused by Candida albicans, which readily colonizes and form biofilms on denture materials. While evidence for biofilms on abiotic and biotic surfaces initiating Candida infections is accumulating, a role for biofilms in DS remains unclear. Read More

    Toxicity of soluble film automatic dishwashing products as reported to the United Kingdom National Poisons Information Service 2008-2015.
    Clin Toxicol (Phila) 2016 Nov 20;54(9):862-866. Epub 2016 Jul 20.
    a NPIS (Birmingham Unit), City Hospital , Birmingham , UK.
    Introduction: Soluble film automatic dishwashing tablets, unlike their traditional counterparts, require no removal from an outer protective wrapper prior to use. Instead, the tablets are enclosed by a water-soluble polyvinyl alcohol film and are loaded straight into the dishwashing machine. They most commonly contain a source of hydrogen peroxide (often as sodium percarbonate) and non-ionic surfactants. Read More

    Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.
    Contact Dermatitis 2016 Sep 11;75(3):157-64. Epub 2016 Jul 11.
    Birmingham Skin Centre, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, B18 7QH, UK.
    Background: (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clinical presentations.

    Objectives: To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clinical data.

    Methods: A retrospective review of results from patch tests performed between July 2002 and September 2015, in one tertiary Cutaneous Allergy Unit, was performed

    Results: A series of 28 (meth)acrylates was applied to 475 patients. Read More

    Stevens-Johnson Syndrome and Corneal Ectasia: Management and a Case for Association.
    Am J Ophthalmol 2016 Sep 4;169:276-81. Epub 2016 Jul 4.
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; Boston Foundation for Sight, Needham, Massachusetts.
    Purpose: To report the occurrence of corneal ectasia (ECT) in patients with history of Stevens-Johnson syndrome (SJS), and to make the case for an association between these 2 diagnoses. We also report the impact of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment on visual acuity (VA) in these patients.

    Design: Retrospective cohort study. Read More

    Burning Mouth Syndrome and "Burning Mouth Syndrome".
    N Y State Dent J 2016 Mar;82(2):36-7
    Burning mouth syndrome is distressing to both the patient and practitioner unable to determine the cause of the patient's symptoms. Burning mouth syndrome is a diagnosis of exclusion, which is used only after nutritional deficiencies, mucosal disease, fungal infections, hormonal disturbances and contact stomatitis have been ruled out. This article will explore the many causes and treatment of patients who present with a chief complaint of "my mouth burns," including symptomatic treatment for those with burning mouth syndrome. Read More

    Concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis.
    Cutis 2016 Jan;97(1):24-7
    From the Department of Allergy, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain.
    Concomitant allergic reactions to multiple drugs are uncommon. We report the case of a 66-year-old woman who presented with concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis. It is notable that one of the reactions was caused by oral nystatin, which generally is not considered to be allergenic due to its poor intestinal absorption. Read More

    [Contact allergic gastritis : Rare manifestation of a metal allergy].
    Hautarzt 2016 May;67(5):359-64
    Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum des Saarlandes, 66421, Homburg/Saar, Deutschland.
    Only a few cases of contact allergic gastritis in patients with nickel allergy have been reported in the literature. We report a case of probable contact-allergic gastritis in a 46-year-old woman. Clinical examination revealed lichenoid mucosal lesions of the gums adjacent to a bridge and crowns that had been implanted several weeks previously. Read More

    Nickel-Related Intestinal Mucositis in IBS-Like Patients: Laser Doppler Perfusion Imaging and Oral Mucosa Patch Test in Use.
    Biol Trace Elem Res 2016 Sep 22;173(1):55-61. Epub 2016 Feb 22.
    Department of Internal Medicine and Medical Specialties, Policlinico Umberto I-Sapienza University, Viale del Policlinico, 155, 00161, Rome, Italy.
    Nickel (Ni) is often the trigger of irritable bowel syndrome (IBS)-like gastrointestinal disorders: its ingestion may cause allergic contact mucositis, identifiable by means of oral mucosa patch test (omPT). OmPT effectiveness has been proven, but it is still an operator-dependent method. Laser Doppler perfusion imaging (LDPI) was tested to support omPT in Ni allergic contact mucositis diagnosis. Read More

    Various clinical conditions can mimic Crimean-Congo hemorrhagic fever in pediatric patients in endemic regions.
    J Infect Public Health 2016 Sep-Oct;9(5):626-32. Epub 2016 Feb 8.
    Erzurum Regional Training and Research Hospital, Department of Pediatric Hematology, Erzurum, Turkey.
    Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease with high mortality. Many disorders can mimic CCHF. It is important to recognize the condition and to perform differential diagnosis in endemic countries. Read More

    Fabrication and Evaluation of Nanostructured Herbal Oil/Hydroxypropyl-β-Cyclodextrin/Polyvinylpyrrolidone Mats for Denture Stomatitis Prevention and Treatment.
    AAPS PharmSciTech 2016 Dec 28;17(6):1441-1449. Epub 2016 Jan 28.
    Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, NakhonPathom, Thailand.
    This work aims to develop the herbal oil-incorporated nanostructure mats with antifungal activity for the prevention and treatment of Candida-associated denture stomatitis. The nanofiber mats loaded with betel oil or clove oil were fabricated via electrospinning process. The morphologies and physicochemical properties of the herbal oil loaded nanofiber mats were examined using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and mechanical testing. Read More

    Herpes Zoster of the Third Division of the Trigeminal Nerve. A Clinical Pathologic Conference.
    N Y State Dent J 2015 Nov;81(6):50-4
    Herpes zoster of the trigeminal nerve is a disease that often challenges dentists and dental specialists trying to make the proper diagnosis, as many ulcerative and vesiculobullous diseases of the mouth have a similar clinical appearance. We report a clinical case in which a 27-year-old patient sought care for this vesicular lesion. Included are the differential diagnosis and treatment modalities that we used to diagnose the disease. Read More

    Molecular characterization and virus neutralization patterns of severe, non-epizootic forms of feline calicivirus infections resembling virulent systemic disease in cats in Switzerland and in Liechtenstein.
    Vet Microbiol 2016 Jan 24;182:202-12. Epub 2015 Nov 24.
    Clinical Laboratory, University of Zurich, Zurich, Switzerland; Center for Clinical Studies, University of Zurich, Zurich, Switzerland. Electronic address:
    Feline calicivirus (FCV) infections are associated with oral ulceration, chronic stomatitis and a limping syndrome. Epizootic outbreaks of virulent systemic disease (VSD) have been reported in the USA and Europe. Here, the molecular characterization and neutralization patterns of FCV isolates from cases of severe, non-epizootic infection associated with skin ulceration and edema are presented. Read More

    [Cheilitis: Diagnosis and treatment].
    Presse Med 2016 Feb 8;45(2):240-50. Epub 2015 Dec 8.
    CHU de Tours, université François-Rabelais, service de dermatologie, 37044 Tours, France; ISP 1282, Inra, université de Tours, 37200 Tours, France. Electronic address:
    The whole examination of oral cavity, other mucosae and skin is required when managing a cheilitis. Irritants (climatic, mechanical, caustic agents.. Read More

    Herbal oral gel induced contact stomatitis along with desquamative gingivitis due to a coloring agent.
    J Indian Soc Periodontol 2015 Sep-Oct;19(5):569-72
    Department of Periodontology, Bhojia Dental College and Hospital, Bhud (Baddi) Distt-Solan, Himachal Pradesh, India.
    Report of a rare case of contact stomatitis manifesting as irregular erosions partially covered with pseudomembrane along with desquamative gingivitis in a 32-year-old female patient is presented. The patient was otherwise healthy and not taking any medication. She gave the history of using curcumin-based oral gel 2 days back. Read More

    Transplacental Transmission of Ovine Herpesvirus 2 in Cattle with Sheep-associated Malignant Catarrhal Fever.
    J Comp Pathol 2015 Nov 18;153(4):206-11. Epub 2015 Nov 18.
    Laboratory of Molecular Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Paraná, Brazil; Multi-User Animal Health Laboratory, Molecular Biology Unit, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Paraná, Brazil.
    Sheep-associated malignant catarrhal fever (SA-MCF) is an important infectious disease of ruminants worldwide that is caused by ovine herpesvirus 2 (OvHV-2). OvHV-2 is transmitted predominantly by contact between infected and susceptible hosts, while the documentation of vertical transmission is rare. This report presents the pathological and molecular findings associated with transplacental transmission of OvHV-2 in cattle. Read More

    Effect of different initial finishes and Parylene coating thickness on the surface properties of coated PMMA.
    J Prosthet Dent 2016 Mar 6;115(3):363-70. Epub 2015 Nov 6.
    Programme Director and Senior Clinical Lecturer, Prosthodontic Unit, UCL Eastman Dental Institute, London, UK. Electronic address:
    Statement Of The Problem: The colonization of microorganisms on acrylic resin dentures may result in denture-induced stomatitis. No efficient coating has yet been proposed to address this issue.

    Purpose: The purpose of this in vitro study was to assess the effect of various initial surface finishes and different Parylene coating thicknesses on the surface roughness (Ra) and surface free energy (SFE) of Parylene coated polymethyl methacrylate (PMMA). Read More

    Cinnamon-induced Oral Mucosal Contact Reaction.
    Open Dent J 2015 31;9:257-9. Epub 2015 Jul 31.
    Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
    Contact stomatitis associated with consumption of cinnamon flavoring agents is a relatively uncommon disorder. Of relevance, both clinical features and the histopathologic findings of this condition are nonspecific, and, more importantly, may resemble some other inflammatory oral mucosa disorders, eventually making diagnosis difficult. Usually a patient exhibits a combination of white and erythematous patches of abrupt onset, accompanied by a burning sensation. Read More

    The Beneficial Effect of Equisetum giganteum L. against Candida Biofilm Formation: New Approaches to Denture Stomatitis.
    Evid Based Complement Alternat Med 2015 28;2015:939625. Epub 2015 Jul 28.
    Department of Stomatology (Pathology), Bauru School of Dentistry, University of São Paulo (USP), Alameda Doutor Octávio Pinheiro Brisolla 9-75, 17012-901 Bauru, SP, Brazil.
    Equisetum giganteum L. (E. giganteum), Equisetaceae, commonly called "giant horsetail," is an endemic plant of Central and South America and is used in traditional medicine as diuretic and hemostatic in urinary disorders and in inflammatory conditions among other applications. Read More

    Evaluation of the Effect of N-Acetylcysteine on Protein Deposition on Contact Lenses in Patients with the Boston Keratoprosthesis Type I.
    J Ocul Pharmacol Ther 2015 Jul-Aug;31(6):314-22. Epub 2015 Jun 4.
    1 Massachusetts Eye Research and Surgery Institution , Cambridge, Massachusetts.
    Purpose: To establish the efficacy of topical N-acetylcysteine (NAC) as a treatment to reduce protein deposition on the contact lens surface.

    Methods: In this prospective, nonrandomized clinical trial, a total of 10 eyes (9 patients) were enrolled from a single center. All patients had a prior ocular history of either a Boston Keratoprosthesis type I or trichiasis from Stevens-Johnson syndrome, which necessitated full-time contact lens wear. Read More

    Clinical assessment of the therapeutic effect of low-level laser therapy on chronic recurrent aphthous stomatitis.
    Biotechnol Biotechnol Equip 2014 Sep 21;28(5):929-933. Epub 2014 Oct 21.
    Department of Oral Surgery, Faculty of Dental Medicine, Medical University of Plovdiv , Plovdiv , Bulgaria.
    The aim of this study was to clinically assess the therapeutic effect of low-level laser therapy (LLLT) on chronic recurrent aphthous stomatitis (RAS) using a protocol we developed especially for the purpose. The study included 180 patients: group 1 (the study group) - 90 patients who received LLLT using a laser operating in the red spectrum (658 nm; in a non-contact mode; power output P = 27 mW; frequency f1 = 5.8 Hz, f2 - continuous waveform; time T = 1. Read More

    Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde.
    Dermatitis 2015 May-Jun;26(3):116-21
    From the Division of Dermatology, University of Calgary, Alberta, Canada.
    Intraoral allergic contact dermatitis (ACD) is an uncommonly reported entity. The most commonly implicated allergens are metals that are incorporated into dental appliances. Intraoral ACD to nonmetal allergens is even less frequently described. Read More

    Low-Molecular-Weight Heparins as Immunomodulators in Dermatology Practice.
    Am J Ther 2016 Nov/Dec;23(6):e1911-e1917
    Department of Dermatology, School of Medicine, Sakarya University, Sakarya, Turkey.
    Low-molecular-weight heparins (LMWHs) have some effects on cell proliferation and inflammation beyond mere anticoagulation. They have been tried on treatment of a few dermatological disorders such as lichen planus, skin wound healing, recurrent aphtous stomatitis, chronic urticaria, and contact hypersensitivity. LMWHs are generally well-tolerated drugs, rarely can lead to severe reactions. Read More

    Biomodulation of Inflammatory Cytokines Related to Oral Mucositis by Low-Level Laser Therapy.
    Photochem Photobiol 2015 Jul-Aug;91(4):952-6. Epub 2015 Mar 28.
    Araraquara School of Dentistry, UNESP - Univ. Estadual Paulista, Araraquara, Brazil.
    This study evaluated the effects of LLLT on the expression of inflammatory cytokines related to the development of oral mucositis by gingival fibroblasts. Primary gingival fibroblasts were seeded on 24-well plates (10(5) cells/well) for 24 h. Fresh serum-free culture medium (DMEM) was then added, and cells were placed in contact with LPS (Escherichia coli, 1 μg mL(-1)), followed by LLLT irradiation (LaserTABLE-InGaAsP diode prototype-780 nm, 25 mW) delivering 0, 0. Read More

    Corneal nerve structure and function after long-term wear of fluid-filled scleral lens.
    Cornea 2015 Apr;34(4):427-32
    *Department of Ophthalmology, Weill Cornell Medical College, New York, NY; and †Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL.
    Purpose: The aim of this study was to determine whether long-term wear of a fluid-filled scleral lens alters basal tear production, corneal sensation, corneal nerve density, and corneal nerve morphology in 2 disease categories.

    Methods: Patients recruited from the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment program at the Weill Cornell Medical College were categorized into 2 groups: distorted corneas (DC) or ocular surface disease (OSD). We measured tear production, central corneal sensation, subbasal nerve density and tortuosity, and stromal nerve thickness before and after long-term wear of the prosthetic device used in PROSE treatment, defined as at least 60 days of wear for a minimum of 8 hours a day. Read More

    Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial.
    J Photochem Photobiol B 2015 Mar 7;144:51-6. Epub 2015 Feb 7.
    Department of Biostatistics, Manipal University, Manipal, Karnataka, India. Electronic address:
    Objectives: Radiotherapy (RT) is treatment of choice for Elderly Head and Neck Cancer (HNC) patients. Oral mucositis (OM) during RT affects patient's routine oral activities and overall health. Low Level Laser Therapy (LLLT) provided some promising results against cancer therapy induced OM in children and adults. Read More

    Herpes simplex virus type 1 infection in two pet marmosets in Japan.
    J Vet Med Sci 2014 Dec 11;76(12):1667-70. Epub 2014 Sep 11.
    Miwa Exotic Animal Hospital, 1-25-5, Komagome, Toshima-ku, Tokyo 170-0003, Japan.
    An 8-month-old common marmoset (Callithrix jacchus) was presented with tic-like symptoms, and a 2-year-old pigmy marmoset (Callithrix pygmaea) was presented with dyspnea and hypersalivation. Both monkeys died within a few days, and necropsies were performed. Histopathological examinations revealed ulcerative stomatitis with epithelial cell swelling and eosinophilic intranuclear inclusion bodies in the oral epithelium of both cases. Read More

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