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    579 results match your criteria Contact Stomatitis

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    Synthesis, Antifungal Activity, and Biocompatibility of novel DABCO Compounds and DABCO- containing Denture Base Resins.
    Antimicrob Agents Chemother 2017 Jan 23. Epub 2017 Jan 23.
    Department of Periodontics, Department of Comprehensive Dentistry and Biomaterials, Department of Oral Biology, Department of Anatomy and Cell Biology, or Department of Prosthodontics, Louisiana State University Health Sciences Center, New Orleans, LA 70119
    The fungal pathogen Candida albicans causes a variety of oral infections including denture stomatitis, which is characterized by inflammation of the oral mucosa in direct contact with dentures, and affects a significant number of otherwise healthy denture wearers. While antifungal treatment reduces symptoms, infections are often recurrent. One strategy to address this problem is to incorporate compounds with fungicidal activities into denture materials to prevent colonization. Read More

    Symptomatic oral lesions may be associated with contact allergy to substances in oral hygiene products.
    Clin Oral Investig 2017 Jan 13. Epub 2017 Jan 13.
    Section for Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, Faculty of Medical and Health Sciences, University of Copenhagen, 20 Noerre Allé, 2200, Copenhagen N, DK, Denmark.
    Objective: Dental materials and oral hygiene products may be responsible for oral contact allergic reactions. We aimed to determine the occurrence of allergies in patients with symptomatic oral lichen planus (OLP), oral lichenoid lesions (OLLs) and stomatitis and investigate if patch testing could identify contact allergies to dental materials and oral hygiene products in these patients.

    Methods: Forty-nine patients (7 men, 42 women) aged 31 to 77 years (61 ± 10. Read More

    Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls.
    J Eur Acad Dermatol Venereol 2016 Dec 21. Epub 2016 Dec 21.
    Department of Odontology, Oral Pathology and Oral Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.
    Background: Lichen planus (LP) is a chronic inflammatory disease of unknown aetiology affecting the skin and oral mucosa. Oral lichenoid lesions (OLLs), like oral contact reactions, may resemble oral lichen planus (OLP) both clinically and histopathologically. As OLP and OLL are hyperkeratotic diseases and filaggrin is essential to keratinization, the distribution of filaggrin may be altered in these lesions. Read More

    Mechanism of membrane fusion induced by vesicular stomatitis virus G protein.
    Proc Natl Acad Sci U S A 2017 Jan 14;114(1):E28-E36. Epub 2016 Dec 14.
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;
    The glycoproteins (G proteins) of vesicular stomatitis virus (VSV) and related rhabdoviruses (e.g., rabies virus) mediate both cell attachment and membrane fusion. Read More

    Beneficial Effects of Everolimus on Autism and Attention-Deficit/Hyperactivity Disorder Symptoms in a Group of Patients with Tuberous Sclerosis Complex.
    J Child Adolesc Psychopharmacol 2016 Oct 31. Epub 2016 Oct 31.
    2 Department of Child Neurology, Istanbul Faculty of Medicine, Istanbul University , Istanbul, Turkey .
    Objectives: Such neuropsychiatric symptoms as autism spectrum disorders, attention-deficit/hyperactivity disorder (ADHD), intellectual disability, aggression, and epilepsy are very common in patients with tuberous sclerosis complex (TSC). Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, is a recent and effective treatment for TSC patients with giant cell astrocytomas and renal angiomyolipoma, and it has been shown to have a potential to reduce tumor volume. However, there is a paucity of studies on the effects of everolimus on neuropsychiatric symptoms. Read More

    Intranasal Location and Immunohistochemical Characterization of the Equine Olfactory Epithelium.
    Front Neuroanat 2016 13;10:97. Epub 2016 Oct 13.
    Institute of Veterinary Pathology, Faculty of Veterinary Medicine, Justus Liebig University Giessen Giessen, Germany.
    The olfactory epithelium (OE) is the only body site where neurons contact directly the environment and are therefore exposed to a broad variation of substances and insults. It can serve as portal of entry for neurotropic viruses which spread via the olfactory pathway to the central nervous system. For horses, it has been proposed and concluded mainly from rodent studies that different viruses, e. Read More

    Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants.
    J Biol Regul Homeost Agents 2016 Jul-Sep;30(3):889-894
    Department of Surgical Sciences, Dental School, University of Turin, Turin, Italy.
    Oral mucositis (OM) may occur in up to 100% of patients undergoing condition regimen to hematopoietic stem cell transplant (HSCT). From the patient’s perspective, OM is one of the most debilitating side effects of transplantation. It is commonly thought that oral hygiene can modify the incidence and severity of oral mucositis, therefore professional oral health care (POHC) is recommended prior to conditioning regimen for HSCT. Read More

    Spatiotemporal dynamics of the Ebola epidemic in Guinea and implications for vaccination and disease elimination: a computational modeling analysis.
    BMC Med 2016 Sep 7;14(1):130. Epub 2016 Sep 7.
    Laboratory for the Modeling of Biological and Socio-technical Systems, Northeastern University, 360 Huntington Ave, Boston, MA, 02115, USA.
    Background: Among the three countries most affected by the Ebola virus disease outbreak in 2014-2015, Guinea presents an unusual spatiotemporal epidemic pattern, with several waves and a long tail in the decay of the epidemic incidence.

    Methods: Here, we develop a stochastic agent-based model at the level of a single household that integrates detailed data on Guinean demography, hospitals, Ebola treatment units, contact tracing, and safe burial interventions. The microsimulation-based model is used to assess the effect of each control strategy and the probability of elimination of the epidemic according to different intervention scenarios, including ring vaccination with the recombinant vesicular stomatitis virus-vectored vaccine. Read More

    Unmet diagnostic needs in contact oral mucosal allergies.
    Clin Mol Allergy 2016 1;14(1):10. Epub 2016 Sep 1.
    Section of Allergology and Clinical Immunology, Department of Internal Medicine and Infectious Diseases, University of Bari Medical School, Bari, Italy.
    The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the oral mucosa to irritant agents and allergens due to anatomical and physiological factors. The spectrum of signs and symptoms of oral contact allergies (OCA) is broad and a large number of condition can be the clinical expression of OCA such as allergic contact stomatitis, allergic contact cheilitis, geographic tongue, oral lichenoid reactions, burning mouth syndrome. Read More

    [Mucosal diseases from an allergological perspective].
    Hautarzt 2016 Oct;67(10):780-785
    Univ. Klinik für Dermatologie, LKH Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.
    The oral allergy syndrome is one of the most common form of food allergy and manifests as contact urticaria of the oral mucosa after consumption of cross reacting foods. Whereas allergic contact stomatitis often occurs due to dental materials, allergic contact cheilitis is usually a reaction due to topical therapeutics like herpes ointments or lip care products. As late type reactions are more frequent than immediate type reactions in the anogenital mucosa, contact dermatitis in this area should be identified via epicutaneous testing. Read More

    Effect of incorporating seed oils on the antifungal property, surface roughness, wettability, weight change, and glucose sorption of a soft liner.
    J Prosthet Dent 2017 Jan 1;117(1):178-185. Epub 2016 Aug 1.
    Professor, Department of Prosthodontics and Crown and Bridge and Implantology, Coorg Institute of Dental Sciences, Virajpet, Coorg, and Rajiv Gandhi University of Health Sciences, Bangalore, India.
    Statement Of Problem: The colonization of Candida albicans on soft liners causes the deterioration of material surface properties and denture stomatitis.

    Purpose: The purpose of this in vitro study was to investigate the effect of incorporating seed oil on the antifungal properties, surface roughness, wettability, weight changes, and glucose adsorption/absorption of a soft liner.

    Material And Methods: Centratherum anthelminticum, Ocimum sanctum Linn, and Linum usitatissimum seed oils were incorporated into a soft liner, and the diameter of the inhibition zone (DIZ) was calculated relative to the growth of C albicans at 24, 48, and 72 hours and 7 days. Read More

    Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during Candida albicans-Associated Denture Stomatitis.
    PLoS One 2016 25;11(7):e0159692. Epub 2016 Jul 25.
    Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America.
    Denture stomatitis (DS) is characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise healthy denture wearers. The disease is caused by Candida albicans, which readily colonizes and form biofilms on denture materials. While evidence for biofilms on abiotic and biotic surfaces initiating Candida infections is accumulating, a role for biofilms in DS remains unclear. Read More

    Toxicity of soluble film automatic dishwashing products as reported to the United Kingdom National Poisons Information Service 2008-2015.
    Clin Toxicol (Phila) 2016 Nov 20;54(9):862-866. Epub 2016 Jul 20.
    a NPIS (Birmingham Unit), City Hospital , Birmingham , UK.
    Introduction: Soluble film automatic dishwashing tablets, unlike their traditional counterparts, require no removal from an outer protective wrapper prior to use. Instead, the tablets are enclosed by a water-soluble polyvinyl alcohol film and are loaded straight into the dishwashing machine. They most commonly contain a source of hydrogen peroxide (often as sodium percarbonate) and non-ionic surfactants. Read More

    Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.
    Contact Dermatitis 2016 Sep 11;75(3):157-64. Epub 2016 Jul 11.
    Birmingham Skin Centre, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, B18 7QH, UK.
    Background: (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clinical presentations.

    Objectives: To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clinical data.

    Methods: A retrospective review of results from patch tests performed between July 2002 and September 2015, in one tertiary Cutaneous Allergy Unit, was performed

    Results: A series of 28 (meth)acrylates was applied to 475 patients. Read More

    Burning Mouth Syndrome and "Burning Mouth Syndrome".
    N Y State Dent J 2016 Mar;82(2):36-7
    Burning mouth syndrome is distressing to both the patient and practitioner unable to determine the cause of the patient's symptoms. Burning mouth syndrome is a diagnosis of exclusion, which is used only after nutritional deficiencies, mucosal disease, fungal infections, hormonal disturbances and contact stomatitis have been ruled out. This article will explore the many causes and treatment of patients who present with a chief complaint of "my mouth burns," including symptomatic treatment for those with burning mouth syndrome. Read More

    Concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis.
    Cutis 2016 Jan;97(1):24-7
    From the Department of Allergy, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain.
    Concomitant allergic reactions to multiple drugs are uncommon. We report the case of a 66-year-old woman who presented with concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis. It is notable that one of the reactions was caused by oral nystatin, which generally is not considered to be allergenic due to its poor intestinal absorption. Read More

    [Contact allergic gastritis : Rare manifestation of a metal allergy].
    Hautarzt 2016 May;67(5):359-64
    Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum des Saarlandes, 66421, Homburg/Saar, Deutschland.
    Only a few cases of contact allergic gastritis in patients with nickel allergy have been reported in the literature. We report a case of probable contact-allergic gastritis in a 46-year-old woman. Clinical examination revealed lichenoid mucosal lesions of the gums adjacent to a bridge and crowns that had been implanted several weeks previously. Read More

    Nickel-Related Intestinal Mucositis in IBS-Like Patients: Laser Doppler Perfusion Imaging and Oral Mucosa Patch Test in Use.
    Biol Trace Elem Res 2016 Sep 22;173(1):55-61. Epub 2016 Feb 22.
    Department of Internal Medicine and Medical Specialties, Policlinico Umberto I-Sapienza University, Viale del Policlinico, 155, 00161, Rome, Italy.
    Nickel (Ni) is often the trigger of irritable bowel syndrome (IBS)-like gastrointestinal disorders: its ingestion may cause allergic contact mucositis, identifiable by means of oral mucosa patch test (omPT). OmPT effectiveness has been proven, but it is still an operator-dependent method. Laser Doppler perfusion imaging (LDPI) was tested to support omPT in Ni allergic contact mucositis diagnosis. Read More

    Various clinical conditions can mimic Crimean-Congo hemorrhagic fever in pediatric patients in endemic regions.
    J Infect Public Health 2016 Sep-Oct;9(5):626-32. Epub 2016 Feb 8.
    Erzurum Regional Training and Research Hospital, Department of Pediatric Hematology, Erzurum, Turkey.
    Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease with high mortality. Many disorders can mimic CCHF. It is important to recognize the condition and to perform differential diagnosis in endemic countries. Read More

    Fabrication and Evaluation of Nanostructured Herbal Oil/Hydroxypropyl-β-Cyclodextrin/Polyvinylpyrrolidone Mats for Denture Stomatitis Prevention and Treatment.
    AAPS PharmSciTech 2016 Dec 28;17(6):1441-1449. Epub 2016 Jan 28.
    Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, NakhonPathom, Thailand.
    This work aims to develop the herbal oil-incorporated nanostructure mats with antifungal activity for the prevention and treatment of Candida-associated denture stomatitis. The nanofiber mats loaded with betel oil or clove oil were fabricated via electrospinning process. The morphologies and physicochemical properties of the herbal oil loaded nanofiber mats were examined using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and mechanical testing. Read More

    Herpes Zoster of the Third Division of the Trigeminal Nerve. A Clinical Pathologic Conference.
    N Y State Dent J 2015 Nov;81(6):50-4
    Herpes zoster of the trigeminal nerve is a disease that often challenges dentists and dental specialists trying to make the proper diagnosis, as many ulcerative and vesiculobullous diseases of the mouth have a similar clinical appearance. We report a clinical case in which a 27-year-old patient sought care for this vesicular lesion. Included are the differential diagnosis and treatment modalities that we used to diagnose the disease. Read More

    Molecular characterization and virus neutralization patterns of severe, non-epizootic forms of feline calicivirus infections resembling virulent systemic disease in cats in Switzerland and in Liechtenstein.
    Vet Microbiol 2016 Jan 24;182:202-12. Epub 2015 Nov 24.
    Clinical Laboratory, University of Zurich, Zurich, Switzerland; Center for Clinical Studies, University of Zurich, Zurich, Switzerland. Electronic address:
    Feline calicivirus (FCV) infections are associated with oral ulceration, chronic stomatitis and a limping syndrome. Epizootic outbreaks of virulent systemic disease (VSD) have been reported in the USA and Europe. Here, the molecular characterization and neutralization patterns of FCV isolates from cases of severe, non-epizootic infection associated with skin ulceration and edema are presented. Read More

    [Cheilitis: Diagnosis and treatment].
    Presse Med 2016 Feb 8;45(2):240-50. Epub 2015 Dec 8.
    CHU de Tours, université François-Rabelais, service de dermatologie, 37044 Tours, France; ISP 1282, Inra, université de Tours, 37200 Tours, France. Electronic address:
    The whole examination of oral cavity, other mucosae and skin is required when managing a cheilitis. Irritants (climatic, mechanical, caustic agents.. Read More

    Herbal oral gel induced contact stomatitis along with desquamative gingivitis due to a coloring agent.
    J Indian Soc Periodontol 2015 Sep-Oct;19(5):569-72
    Department of Periodontology, Bhojia Dental College and Hospital, Bhud (Baddi) Distt-Solan, Himachal Pradesh, India.
    Report of a rare case of contact stomatitis manifesting as irregular erosions partially covered with pseudomembrane along with desquamative gingivitis in a 32-year-old female patient is presented. The patient was otherwise healthy and not taking any medication. She gave the history of using curcumin-based oral gel 2 days back. Read More

    Transplacental Transmission of Ovine Herpesvirus 2 in Cattle with Sheep-associated Malignant Catarrhal Fever.
    J Comp Pathol 2015 Nov 18;153(4):206-11. Epub 2015 Nov 18.
    Laboratory of Molecular Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Paraná, Brazil; Multi-User Animal Health Laboratory, Molecular Biology Unit, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Paraná, Brazil.
    Sheep-associated malignant catarrhal fever (SA-MCF) is an important infectious disease of ruminants worldwide that is caused by ovine herpesvirus 2 (OvHV-2). OvHV-2 is transmitted predominantly by contact between infected and susceptible hosts, while the documentation of vertical transmission is rare. This report presents the pathological and molecular findings associated with transplacental transmission of OvHV-2 in cattle. Read More

    Effect of different initial finishes and Parylene coating thickness on the surface properties of coated PMMA.
    J Prosthet Dent 2016 Mar 6;115(3):363-70. Epub 2015 Nov 6.
    Programme Director and Senior Clinical Lecturer, Prosthodontic Unit, UCL Eastman Dental Institute, London, UK. Electronic address:
    Statement Of The Problem: The colonization of microorganisms on acrylic resin dentures may result in denture-induced stomatitis. No efficient coating has yet been proposed to address this issue.

    Purpose: The purpose of this in vitro study was to assess the effect of various initial surface finishes and different Parylene coating thicknesses on the surface roughness (Ra) and surface free energy (SFE) of Parylene coated polymethyl methacrylate (PMMA). Read More

    Cinnamon-induced Oral Mucosal Contact Reaction.
    Open Dent J 2015 31;9:257-9. Epub 2015 Jul 31.
    Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
    Contact stomatitis associated with consumption of cinnamon flavoring agents is a relatively uncommon disorder. Of relevance, both clinical features and the histopathologic findings of this condition are nonspecific, and, more importantly, may resemble some other inflammatory oral mucosa disorders, eventually making diagnosis difficult. Usually a patient exhibits a combination of white and erythematous patches of abrupt onset, accompanied by a burning sensation. Read More

    The Beneficial Effect of Equisetum giganteum L. against Candida Biofilm Formation: New Approaches to Denture Stomatitis.
    Evid Based Complement Alternat Med 2015 28;2015:939625. Epub 2015 Jul 28.
    Department of Stomatology (Pathology), Bauru School of Dentistry, University of São Paulo (USP), Alameda Doutor Octávio Pinheiro Brisolla 9-75, 17012-901 Bauru, SP, Brazil.
    Equisetum giganteum L. (E. giganteum), Equisetaceae, commonly called "giant horsetail," is an endemic plant of Central and South America and is used in traditional medicine as diuretic and hemostatic in urinary disorders and in inflammatory conditions among other applications. Read More

    Evaluation of the Effect of N-Acetylcysteine on Protein Deposition on Contact Lenses in Patients with the Boston Keratoprosthesis Type I.
    J Ocul Pharmacol Ther 2015 Jul-Aug;31(6):314-22. Epub 2015 Jun 4.
    1 Massachusetts Eye Research and Surgery Institution , Cambridge, Massachusetts.
    Purpose: To establish the efficacy of topical N-acetylcysteine (NAC) as a treatment to reduce protein deposition on the contact lens surface.

    Methods: In this prospective, nonrandomized clinical trial, a total of 10 eyes (9 patients) were enrolled from a single center. All patients had a prior ocular history of either a Boston Keratoprosthesis type I or trichiasis from Stevens-Johnson syndrome, which necessitated full-time contact lens wear. Read More

    Clinical assessment of the therapeutic effect of low-level laser therapy on chronic recurrent aphthous stomatitis.
    Biotechnol Biotechnol Equip 2014 Sep 21;28(5):929-933. Epub 2014 Oct 21.
    Department of Oral Surgery, Faculty of Dental Medicine, Medical University of Plovdiv , Plovdiv , Bulgaria.
    The aim of this study was to clinically assess the therapeutic effect of low-level laser therapy (LLLT) on chronic recurrent aphthous stomatitis (RAS) using a protocol we developed especially for the purpose. The study included 180 patients: group 1 (the study group) - 90 patients who received LLLT using a laser operating in the red spectrum (658 nm; in a non-contact mode; power output P = 27 mW; frequency f1 = 5.8 Hz, f2 - continuous waveform; time T = 1. Read More

    Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde.
    Dermatitis 2015 May-Jun;26(3):116-21
    From the Division of Dermatology, University of Calgary, Alberta, Canada.
    Intraoral allergic contact dermatitis (ACD) is an uncommonly reported entity. The most commonly implicated allergens are metals that are incorporated into dental appliances. Intraoral ACD to nonmetal allergens is even less frequently described. Read More

    Low-Molecular-Weight Heparins as Immunomodulators in Dermatology Practice.
    Am J Ther 2016 Nov/Dec;23(6):e1911-e1917
    Department of Dermatology, School of Medicine, Sakarya University, Sakarya, Turkey.
    Low-molecular-weight heparins (LMWHs) have some effects on cell proliferation and inflammation beyond mere anticoagulation. They have been tried on treatment of a few dermatological disorders such as lichen planus, skin wound healing, recurrent aphtous stomatitis, chronic urticaria, and contact hypersensitivity. LMWHs are generally well-tolerated drugs, rarely can lead to severe reactions. Read More

    Biomodulation of Inflammatory Cytokines Related to Oral Mucositis by Low-Level Laser Therapy.
    Photochem Photobiol 2015 Jul-Aug;91(4):952-6. Epub 2015 Mar 28.
    Araraquara School of Dentistry, UNESP - Univ. Estadual Paulista, Araraquara, Brazil.
    This study evaluated the effects of LLLT on the expression of inflammatory cytokines related to the development of oral mucositis by gingival fibroblasts. Primary gingival fibroblasts were seeded on 24-well plates (10(5) cells/well) for 24 h. Fresh serum-free culture medium (DMEM) was then added, and cells were placed in contact with LPS (Escherichia coli, 1 μg mL(-1)), followed by LLLT irradiation (LaserTABLE-InGaAsP diode prototype-780 nm, 25 mW) delivering 0, 0. Read More

    Corneal nerve structure and function after long-term wear of fluid-filled scleral lens.
    Cornea 2015 Apr;34(4):427-32
    *Department of Ophthalmology, Weill Cornell Medical College, New York, NY; and †Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL.
    Purpose: The aim of this study was to determine whether long-term wear of a fluid-filled scleral lens alters basal tear production, corneal sensation, corneal nerve density, and corneal nerve morphology in 2 disease categories.

    Methods: Patients recruited from the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment program at the Weill Cornell Medical College were categorized into 2 groups: distorted corneas (DC) or ocular surface disease (OSD). We measured tear production, central corneal sensation, subbasal nerve density and tortuosity, and stromal nerve thickness before and after long-term wear of the prosthetic device used in PROSE treatment, defined as at least 60 days of wear for a minimum of 8 hours a day. Read More

    Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial.
    J Photochem Photobiol B 2015 Mar 7;144:51-6. Epub 2015 Feb 7.
    Department of Biostatistics, Manipal University, Manipal, Karnataka, India. Electronic address:
    Objectives: Radiotherapy (RT) is treatment of choice for Elderly Head and Neck Cancer (HNC) patients. Oral mucositis (OM) during RT affects patient's routine oral activities and overall health. Low Level Laser Therapy (LLLT) provided some promising results against cancer therapy induced OM in children and adults. Read More

    Herpes simplex virus type 1 infection in two pet marmosets in Japan.
    J Vet Med Sci 2014 Dec 11;76(12):1667-70. Epub 2014 Sep 11.
    Miwa Exotic Animal Hospital, 1-25-5, Komagome, Toshima-ku, Tokyo 170-0003, Japan.
    An 8-month-old common marmoset (Callithrix jacchus) was presented with tic-like symptoms, and a 2-year-old pigmy marmoset (Callithrix pygmaea) was presented with dyspnea and hypersalivation. Both monkeys died within a few days, and necropsies were performed. Histopathological examinations revealed ulcerative stomatitis with epithelial cell swelling and eosinophilic intranuclear inclusion bodies in the oral epithelium of both cases. Read More

    Evaluation of cytotoxic effects of Anbarnesa on fibroblast L929: Can it be used as a mouthwash?
    Anc Sci Life 2014 Apr-Jun;33(4):203-7
    Department of Statistics, Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
    Aims: In Iranian traditional medicine Anbarnesa (derived from smoke from burning female donkey's stool) has been used to treat ulcers and inflammatory conditions like stomatitis and ear infections (otitis). We assess the properties of Anbarnesa as an alternative mouthwash.

    Materials And Methods: In this experimental study, Anbarnesa smoke was analyzed using aGC-mass device. Read More

    Tonsillitis and sore throat in children.
    GMS Curr Top Otorhinolaryngol Head Neck Surg 2014 1;13:Doc07. Epub 2014 Dec 1.
    Dep. of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Centre, University of Munich, Munich, Germany.
    Surgery of the tonsils is still one of the most frequent procedures during childhood. Due to a series of fatal outcomes after hemorrhage in children in Austria in 2006, the standards and indications for tonsillectomy have slowly changed in Germany. However, no national guidelines exist and the frequency of tonsil surgery varies across the country. Read More

    Sensitization to palladium and nickel in Europe and the relationship with oral disease and dental alloys.
    Contact Dermatitis 2015 May 12;72(5):286-96. Epub 2015 Jan 12.
    Department of Dental Materials Science, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
    Background: The role of palladium and nickel sensitization in oral disease and dermatitis is not fully understood.

    Objectives: To investigate whether sensitization to these metals was associated with exposure to dental alloys and oral and skin complaints/symptoms in a European multicentre study.

    Methods: In six dermatology clinics, patch tests with palladium (3% Na2 PdCl4 ; Pd = 102. Read More

    An antifungal coating for dental silicones composed of chlorhexidine nanoparticles.
    J Dent 2015 Mar 13;43(3):362-72. Epub 2014 Dec 13.
    Oral Nanoscience, School of Oral and Dental Sciences, University of Bristol, Bristol, UK. Electronic address:
    Objectives: The aims of this study were to synthesise a range of chlorhexidine-containing nanoparticles (CHX-NPs), and investigate the feasibility of using these as an antifungal coating for dental silicones.

    Methods: CHX-NPs were precipitated in aqueous reaction by mixing solutions of CHX digluconate with solutions of sodium triphosphate (TP), trimetaphosphate (TMP) or hexametaphosphate (HMP). CHX-NPs were deposited on commercial dental silicones by immersion coating, and these were characterised for hydrophilicity (contact angle) and water uptake (mass change). Read More

    Ebola virus (EBOV) infection: Therapeutic strategies.
    Biochem Pharmacol 2015 Jan 4;93(1):1-10. Epub 2014 Dec 4.
    Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. Electronic address:
    Within less than a year after its epidemic started (in December 2013) in Guinea, Ebola virus (EBOV), a member of the filoviridae, has spread over a number of West-African countries (Guinea, Sierra Leone and Liberia) and gained allures that have been unprecedented except by human immunodeficiency virus (HIV). Although EBOV is highly contagious and transmitted by direct contact with body fluids, it could be counteracted by the adequate chemoprophylactic and -therapeutic interventions: vaccines, antibodies, siRNAs (small interfering RNAs), interferons and chemical substances, i.e. Read More

    Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats.
    J Neurosci Methods 2015 Jan 29;239:162-9. Epub 2014 Oct 29.
    Division of Physiology, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka 803-8580, Japan. Electronic address:
    Background: Stomatitis induces severe and painful hypersensitivity to pungency and physical contact during meals. Many studies have used anesthetized animals to examine evoked nociception in the oral mucosa, but no reports have used traditional behavioral assays to evaluate nociception in conscious animals.

    New Methods: We developed two new methods of applying chemical or mechanical stimulation directly to the oral mucosa of the mandibular vestibule of conscious rats. Read More

    Influence of melaleuca and copaiba oils on Candida albicans adhesion.
    Gerodontology 2016 Sep 1;33(3):380-5. Epub 2014 Dec 1.
    Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
    Objective: To evaluate the efficacy of Melaleuca alternifolia and Copaifera officinalis in inhibiting the adhesion of Candida albicans biofilm.

    Background: Over 65% of denture wearers suffer from denture stomatitis, which is one of the most prevalent forms of oral candidiasis. This disease is characterised by the inflammation of the oral mucosa in contact with the contaminated denture. Read More

    Amyotrophic lateral sclerosis-linked mutant VAPB inclusions do not interfere with protein degradation pathways or intracellular transport in a cultured cell model.
    PLoS One 2014 19;9(11):e113416. Epub 2014 Nov 19.
    Institute of Neuroscience, Consiglio Nazionale delle Ricerche, and Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milano, Italy; Department of Health Science, Magna Graecia University of Catanzaro, Catanzaro, Italy.
    VAPB is a ubiquitously expressed, ER-resident adaptor protein involved in interorganellar lipid exchange, membrane contact site formation, and membrane trafficking. Its mutant form, P56S-VAPB, which has been linked to a dominantly inherited form of Amyotrophic Lateral Sclerosis (ALS8), generates intracellular inclusions consisting in restructured ER domains whose role in ALS pathogenesis has not been elucidated. P56S-VAPB is less stable than the wild-type protein and, at variance with most pathological aggregates, its inclusions are cleared by the proteasome. Read More

    Human herpes simplex virus type 1 in confiscated gorilla.
    Emerg Infect Dis 2014 Nov;20(11):1883-6
    In 2007, we detected human herpes simplex virus type 1, which caused stomatitis, in a juvenile confiscated eastern lowland gorilla (Gorilla beringei graueri) that had a high degree of direct contact with human caretakers. Our findings confirm that pathogens can transfer between nonhuman primate hosts and humans. Read More

    Prosthetic replacement of the ocular surface ecosystem as treatment for ocular surface disease in patients with a history of Stevens-Johnson syndrome/toxic epidermal necrolysis.
    Ophthalmology 2015 Feb 1;122(2):248-53. Epub 2014 Oct 1.
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; Boston Foundation for Sight, Needham, Massachusetts. Electronic address:
    Purpose: To report the visual outcomes of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in patients with ocular surface disease related to Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).

    Design: Retrospective cohort study.

    Subjects: We included 86 patients (167 eyes) with history of SJS/TEN who underwent PROSE treatment from January 1, 2006, to January 1, 2011. Read More

    Immediate loading of mandibular overdentures supported by one-piece, direct metal laser sintering mini-implants: a short-term prospective clinical study.
    J Periodontol 2015 Feb 2;86(2):192-200. Epub 2014 Oct 2.
    Department of Surgical and Morphological Science, Dental School, University of Insubria, Varese, Italy.
    Background: Only a few studies have dealt with immediately loaded, unsplinted mini-implants supporting ball attachment-retained mandibular overdentures (ODs). The aim of this study is to evaluate treatment outcomes of ball attachment-retained mandibular ODs supported by one-piece, unsplinted, immediately loaded, direct metal laser sintering (DMLS) mini-implants.

    Methods: Over a 4-year period (2009 to 2012), all patients referred to the Dental Clinic, University of Varese, and to a private practice for treatment with mandibular ODs were considered for inclusion in this study. Read More

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