303,229 results match your criteria Contact Lens Spectrum[Journal]


No Difference in Prevalence of Transmitted Drug Resistance between Injection Drug Users and Non-Injection Drug Users: A Cross-Sectional Study among Antiretroviral Treatment-Naïve HIV Patients.

Intervirology 2019 Apr 24:1-11. Epub 2019 Apr 24.

Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, China,

Objectives: The epidemiological evidence is inconsistent about whether HIV-positive injection drug users (IDUs) are at higher risk of developing antiretroviral resistance than any other HIV-positive populations. This study aims to investigate and compare transmitted drug resistance (TDR) between IDUs and non-IDUs in Lingshan County, an HIV-hit region in Guangxi, China, where IDU and heterosexual transmission were the two dominant transmission routes and roughly equally contributed to the local HIV transmission.

Methods: A cross-sectional study was conducted among newly diagnosed and antiretroviral-treatment (ART)-naïve HIV-1 patients from Lingshan County. Read More

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https://www.karger.com/Article/FullText/499367
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http://dx.doi.org/10.1159/000499367DOI Listing
April 2019
5 Reads

Statistical mechanical properties of sequence space determine the efficiency of the various algorithms to predict interaction energies and native contacts from protein coevolution.

Phys Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Physics, Universita degli Studi di Milano, Milano, Lombardia, ITALY.

Studying evolutionary correlations in alignments of homologous sequences by means of an inverse Potts model has proven useful to obtain residue-residue contact energies and to predict contacts in proteins. The quality of the results depend much on several choices of the detailed model and on the algorithms used. We built, in a very controlled way, synthetic alignments with statistical properties similar to those of real proteins, and used them to assess the performance of different inversion algorithms and of their variants. Read More

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http://dx.doi.org/10.1088/1478-3975/ab1c15DOI Listing

Rodent-borne infections in rural Ghanaian farming communities.

PLoS One 2019 24;14(4):e0215224. Epub 2019 Apr 24.

United States Naval Medical Research Unit Number 3, Ghana Detachment, Accra, Ghana.

Rodents serve as reservoirs and/or vectors for several human infections of high morbidity and mortality in the tropics. Population growth and demographic shifts over the years have increased contact with these mammals, thereby increasing opportunities for disease transmission. In Africa, the burden of rodent-borne diseases is not well described. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215224PLOS

Speech-Language Pathology and the Youth Offender: Epidemiological Overview and Roadmap for Future Speech-Language Pathology Research and Scope of Practice.

Authors:
Pamela C Snow

Lang Speech Hear Serv Sch 2019 Apr;50(2):324-339

La Trobe Rural Health School, Bendigo, Victoria, Australia.

Purpose This article is concerned with the growing body of international evidence indicating that adolescents in contact with the youth justice system are likely to have severely compromised oral language skills, receptively and expressively. A smaller, but persuasive, literature also points to poor literacy skills in this population. Language and literacy skills underpin academic, social, and vocational success ( C. Read More

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http://dx.doi.org/10.1044/2018_LSHSS-CCJS-18-0027DOI Listing

Visual Perception of Joint Stiffness from Multi-Joint Motion.

J Neurophysiol 2019 Apr 24. Epub 2019 Apr 24.

Mechanical Engineering and Brain & Cognitive Sci., MIT, United States.

Humans have an astonishing ability to extract hidden information from the movements of others. For example, even with only limited kinematic information, humans can distinguish between biological and non-biological motion, identify the age and gender of a human demonstrator, and recognize what action a human demonstrator is performing. It is unknown, however, whether they can also estimate hidden mechanical properties of another's limbs simply by observing their motions. Read More

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http://dx.doi.org/10.1152/jn.00514.2018DOI Listing

Validation of the Spanish Version of the Beginning Breastfeeding Survey-Cumulative: A Follow-up Study.

J Hum Lact 2019 Apr 24:890334419840003. Epub 2019 Apr 24.

2 Department of Nursing, University of Alicante, Alicante, Spain.

Background: The Beginning Breastfeeding Survey-Cumulative (BBSC) is an instrument that assesses the overall maternal perception of breastfeeding effectiveness during the early postpartum period.

Research Aims: The aims of this study were to adapt and validate a Spanish version of the BBSC and provide new evidence regarding its validity.

Methods: A standard forward and back-translation process was used to obtain the Spanish version of the questionnaire (BBSC-E). Read More

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http://dx.doi.org/10.1177/0890334419840003DOI Listing

Binary Assembly of PbS and Au Nanocrystals: Patchy PbS Surface Ligand Coverage Stabilizes the CuAu Superlattice.

ACS Nano 2019 Apr 24. Epub 2019 Apr 24.

Self-assembly of two sizes of nearly-spherical colloidal nanocrystals (NCs) capped with hydrocarbon surface ligands has been shown to produce more than twenty distinct phases of binary nanocrystal superlattices (BNSLs). Such structural diversity, in striking contrast to binary systems of micron-sized colloidal beads, cannot be rationalized by models assuming entropy-driven crystallization of simple spheres. In this work, we show that the PbS ligand binding equilibrium controls the relative stability of two closely related BNSL structures featuring alternating layers of PbS and Au NCs. Read More

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http://dx.doi.org/10.1021/acsnano.9b00006DOI Listing

15% Efficiency Ultrathin Silicon Solar Cells with Fluorine Doped Titanium Oxide and Chemically Tailored Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) as Asymmetric Heterocontacts.

ACS Nano 2019 Apr 24. Epub 2019 Apr 24.

In order to achieve a high performance-to-cost ratio to photovoltaic devices, the development of crystalline silicon (c-Si) solar cells with thinner substrates and simpler fabrication routes are important steps. Thin-film heterojunction solar cells (HSCs) with dopant-free and carrier-selective configurations look like ideal candidates in this respect. Here, we investigated the application of n-type silicon/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) HSCs on periodic nano-pyramids textured, ultrathin c-Si (~ 25 μm) substrates. Read More

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http://dx.doi.org/10.1021/acsnano.9b01754DOI Listing

Ion Association in Lanthanide Chloride Solutions.

Chemistry 2019 Apr 24. Epub 2019 Apr 24.

UNITED KINGDOM.

A better understanding of the solution chemistry of the lanthanide (Ln) salts in water would have wide ranging implications in materials processing, waste management, element tracing, medicine and minerals processing - particularly given governmental concerns about Ln security of supply. Despite much effort, even in simple systems, the mechanisms and thermodynamics of Ln(III) association with small anions remain unclear. In the present study, molecular dynamics (MD), using a newly developed force field, provide new insights into LnCl₃(aq) solutions. Read More

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http://dx.doi.org/10.1002/chem.201900945DOI Listing

WITHDRAWN: Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults.

Cochrane Database Syst Rev 2019 Apr 24;4:CD009857. Epub 2019 Apr 24.

Cochrane Croatia, School of Medicine, University of Split, Soltanska 2, Split, Splitsko-dalmatinska County, Croatia, 21 000.

Background: Effective oral hygiene is a crucial factor in maintaining good oral health, which is associated with overall health and health-related quality of life. Dental floss has been used for many years in conjunction with toothbrushing for removing dental plaque in between teeth, however, interdental brushes have been developed which many people find easier to use than floss, providing there is sufficient space between the teeth.

Objectives: To evaluate the effects of interdental brushing in addition to toothbrushing, as compared with toothbrushing alone or toothbrushing and flossing for the prevention and control of periodontal diseases, dental plaque and dental caries. Read More

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http://dx.doi.org/10.1002/14651858.CD009857.pub3DOI Listing

Z-scheme photocatalyst systems employing Rh- and Ir-doped metal oxide materials for water splitting under visible light irradiation.

Faraday Discuss 2019 Apr 24. Epub 2019 Apr 24.

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. and Photocatalysis International Research Center, Research Institute for Science and Technology, Tokyo University of Science, 2641, Yamazaki, Noda-shi, Chiba-ken 278-8510, Japan.

Various types of Z-scheme systems for water splitting under visible light irradiation were successfully developed by employing Rh- and Ir-doped metal oxide powdered materials with relatively narrow energy gaps (EG): BaTa2O6:Ir,La (EG: 1.9-2.0 eV), NaTaO3:Ir,La (EG: 2. Read More

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http://dx.doi.org/10.1039/c8fd00209fDOI Listing

EphrinB2/EphB4 Signaling Regulates DPSCs to Induce Sprouting Angiogenesis of Endothelial Cells.

J Dent Res 2019 Apr 24:22034519843886. Epub 2019 Apr 24.

1 Endodontology, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong, China.

Dental pulp stem cells (DPSCs) are capable of facilitating angiogenesis resembling pericytes when located adjacent to endothelial cells (ECs). Nevertheless, the precise mechanisms orchestrating their proangiogenic functions remain unclear. Using a 3-dimensional (3-D) fibrin gel model, we aimed to investigate whether EphrinB2/EphB4 signaling in DPSCs plays a role in supporting vascular morphogenesis mediated by ECs, together with the underlying mechanism involved. Read More

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http://dx.doi.org/10.1177/0022034519843886DOI Listing

The training and praxis of the nurse in the light of nursing theories.

Rev Bras Enferm 2019 Mar-Apr;72(2):566-570. Epub 2019 Apr 18.

Universidade Estadual Paulista Júlio de Mesquita Filho. Botucatu-SP, Brasil.

Objective: to report the experience of the development of nursing knowledge from nursing theories and points of contact with the nurse's praxis.

Method: case report on the reflections on contents addressed in the discipline offered in the Graduate Program in Nursing in a federal public university. The students presented seminars approaching the main nursing theories, generating extensive discussion and correlating them with the nurse's practice. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0034-7167-2018-0394DOI Listing
April 2019
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Ozone against Pseudomonas aeruginosa biofilms in contact lenses storage cases.

Rev Inst Med Trop Sao Paulo 2019 Apr 18;61:e23. Epub 2019 Apr 18.

Universidade Federal de Alfenas, Instituto de Biociências, Departamento de Microbiologia e Imunologia, Alfenas, Minas Gerais, Brazil.

Pseudomonas aeruginosa is associated with ocular infections such as keratitis. Multipurpose contact lens solutions can be used for washing, disinfection and storage of contact lenses, however, P. aeruginosa biofilm disinfection by this method is unsatisfactory. Read More

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http://dx.doi.org/10.1590/S1678-9946201961023DOI Listing

Critical evaluation of the surgical techniques to correct the equinus deformity.

Rev Col Bras Cir 2019 18;46(1):e2054. Epub 2019 Apr 18.

Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor, Ribeirão Preto, SP, Brasil.

The equinus deformity causes changes in the foot contact and may affect more proximal anatomical regions, such as the knee, hip and trunk, potentially leading to gait disorders. The equinus is usually secondary to retraction, shortening and/or spasticity of the triceps surae, and it may require surgical correction. Surgery for the correction of equinus is one of the oldest procedures in Orthopedics, and it was initially performed only at the calcaneus tendon. Read More

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http://dx.doi.org/10.1590/0100-6991e-20192054DOI Listing

Gecko toe pads inspired in situ switchable superhydrophobic shape memory adhesive film.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Recently, smart adhesive superhydrophobic surfaces have attracted much attention. However, it is still a challenge to obtain a superhydrophobic surface with shape memory adhesive performance. Herein, inspired by the special back-scrolling/unfolding ability of gecko toe pads and corresponding tunable adhesion, we report such a film produced by sticking a layer of superhydrophobic pillar structured polyurethane (s-PU) onto a shape memory polyurethane-cellulose nanofiber (PU-CNF) substrate to mimic the hair-like skin structure and underlying muscle of the gecko toe pads, respectively. Read More

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http://dx.doi.org/10.1039/c9nr00154aDOI Listing

Transmission Routes of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in a Neonatology Ward in Madagascar.

Am J Trop Med Hyg 2019 Apr 22. Epub 2019 Apr 22.

UMR1181 Biostatistique, Biomathématique, Pharmaco-épidémiologie et Maladies Infectieuses (B2PHI), Institut Pasteur, Inserm, Université de Versailles-Saint-Quentin-en-Yvelines (UVSQ), Paris, France.

The diffusion of extended-spectrum beta-lactamase (E-ESBL)-producing Enterobacteriaceae is a major concern worldwide, especially in low-income countries, where they may lead to therapeutic failures. In hospitals, where colonization is the highest, E-ESBL transmission is poorly understood, limiting the possibility of establishing effective control measures. We assessed E-ESBL-acquisition routes in a neonatalogy ward in Madagascar. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0410DOI Listing

The tinnitus patient information pack: usefulness in intrusive tinnitus.

Int J Health Care Qual Assur 2019 Mar;32(2):360-365

Department of Otolaryngology, Southend University Hospital NHS Foundation Trust , Essex, UK.

Purpose: The purpose of this paper is to determine a tinnitus patient information pack's (TPIP) usefulness in patients suffering with tinnitus with respect to their need for further tinnitus retraining therapy (TRT) and in reducing TRT cancellations and non-attenders.

Design/methodology/approach: The paper consists of prospective case series in a district general hospital ENT out-patient department.

Findings: Patients with tinnitus-related symptoms constitute around 2 per cent of the ENT OPD workload at the West Middlesex Hospital, Chelsea & Westminster NHS Trust, London, i. Read More

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http://dx.doi.org/10.1108/IJHCQA-03-2018-0071DOI Listing

Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T-cell responses.

Am J Physiol Renal Physiol 2019 Apr 24. Epub 2019 Apr 24.

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Germany.

In immune-mediated glomerular diseases like crescentic glomerulonephritis (cGN), inflammatory CD4 T cells accumulate within the tubulointerstitial compartment in close contact to proximal and distal tubular epithelial cells and drive renal inflammation and tissue damage. However, whether renal epithelial cell populations play a role in the pathogenesis of cGN by modulating CD4 T-cell responses is less clear. In this study, we aim at investigating the potential of renal epithelial cells to function as antigen-presenting cells (APCs) thereby stimulating CD4 T-cell responses . Read More

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http://dx.doi.org/10.1152/ajprenal.00427.2018DOI Listing

Measuring intelligibility in signed languages.

Clin Linguist Phon 2019 Apr 24:1-18. Epub 2019 Apr 24.

b School of Teacher Education , Charles Sturt University , Bathurst , Australia.

Intelligibility of spoken languages is a widely discussed construct; however, intelligibility, as it pertains to signed languages, has rarely been considered. This study provides an initial investigation of the construct of intelligibility in American Sign Language (ASL) and evaluates potential measures for self-report and expert ratings of sign intelligibility that examined the frequency of understanding, amount of understanding, and ease of understanding. Participants were 66 college students (42 Deaf, 24 hearing) who had self-rated ASL skills ranging from poor to excellent. Read More

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http://dx.doi.org/10.1080/02699206.2019.1600169DOI Listing

pJ-Level Energy-Consuming, Low-Voltage Ferroelectric Organic Field-Effect Transistor Memories.

J Phys Chem Lett 2019 Apr 24. Epub 2019 Apr 24.

Ferroelectric organic field-effect transistors (Fe-OFETs) have attracted considerable attention because of their promising potential for memory applications, while a critical issue is the large energy consumption as mainly caused by a high operating voltage and slow data switching. Here, we employ ultrathin ferroelectric polymer and semiconducting molecular crystals to create low-voltage Fe-OFET memories. Devices only require a pJ-level energy consumption. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b00864DOI Listing

[Construction of controllable polyethylene glycol bioactive coating with hemocompatibility from the surface of modified glass substrate].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):260-266

School of Chemical and Pharmaceutical Engineering, Huanghuai University, Zhumadian, Henan 463000, P.R.China.

A diblock copolymer, poly(ethylene glycol) methacrylate-block-glycidyl methacrylate (PEGMA-GMA), was prepared on glass substrate by surface-initiated atom transfer radical polymerization (SI-ATRP), and endothelial specific peptide Arg-Glu-Asp-Val (REDV) was immobilized at the end of the PEGMA-GMA polymer brush by ring opening reaction through the rich epoxy groups in the GMA. The structure and hydrophilicity of the polymer brushes were characterized by static water contact angle, X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). The results showed that the REDV modified copolymer brushes were successfully constructed on the glass substrates. Read More

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http://dx.doi.org/10.7507/1001-5515.201705032DOI Listing

[Fabrication of hydrophilic medical catheter with hydrogel grafting and the in vivo evaluation of its histo-compatibility].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):238-244

The Otolaryngology Department, Lihuili Hospital Affiliated to the Medical School of Ningbo University, Ningbo, Zhejiang 315041, P.R.China.

The biocompatible hydrogel was fabricated under suitable conditions with natural dextran and polyethylene glycol (PEG) as the reaction materials. The oligomer (Dex-AI) was firstly synthesized with dextran and allylisocyanate (AI). This Dex-AI was then reacted with poly (ethyleneglycoldiacrylate) (PEGDA) under the mass ratio of 4∶6 to get hydrogel (DP) with the maximum water absorption of 810%. Read More

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http://dx.doi.org/10.7507/1001-5515.201707017DOI Listing

[Influence of valve height on the opening/closure performance of transplanted aortic valve].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):199-205

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R.China.

Valve transplantation is often used in the treatment of aortic valve insufficiency. However, after surgery, the reconstructed aortic roots have an expansion phenomenon, in which the lack of valve height causes the aortic valve to close again. In this paper, the effects of different aortic valve height design on valve opening and closing performance were studied. Read More

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http://dx.doi.org/10.7507/1001-5515.201709061DOI Listing

A new treatment for presumed corneal epithelial inclusion cyst in a shih-tzu dog.

Authors:
S Kang E Park K Seo

J Small Anim Pract 2019 Apr 23. Epub 2019 Apr 23.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea.

An 8-year-old female shih-tzu was assessed for a 3-year history of yellow intrastromal material in the right eye. Slit-lamp biomicroscopy showed a yellow lesion in the upper half of the cornea, superficial corneal neovascularisation and oedema with negative fluorescein staining in the right eye. Ultrasound biomicroscopy revealed a nearly anechoic cystic space surrounded by hyperechoic oedematous cornea separating the stroma at three-quarters of the corneal depth. Read More

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http://dx.doi.org/10.1111/jsap.13008DOI Listing

Robot-assisted cervical esophagectomy (RACE procedure) using a single port combined with a transhiatal approach in a rendezvous technique: a case series.

Langenbecks Arch Surg 2019 Apr 23. Epub 2019 Apr 23.

Department for General, Visceral, Thoracic, Transplantation, and Pediatric Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.

Background: Difficulties in thoracic access and the risk of pulmonary complications are major problems in esophageal surgery. Transhiatal techniques have been described to avoid the thoracic approach, but their oncological radicality continues to be questioned. A combination of a cervical and transhiatal approach, however, appears promising. Read More

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http://dx.doi.org/10.1007/s00423-019-01785-yDOI Listing

Permanently hydrophilic, piezoelectric PVDF nanofibrous scaffolds promoting unaided electromechanical stimulation on osteoblasts.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

Department de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain.

Biomimetic functional scaffolds for tissue engineering should fulfil specific requirements concerning structural, bio-chemical and electro-mechanical characteristics, depending on the tissue that they are designed to resemble. In bone tissue engineering, piezoelectric materials based on poly(vinylidene fluoride) (PVDF) are on the forefront, due to their inherent ability to generate surface charges under minor mechanical deformations. Nevertheless, PVDF's high hydrophobicity hinders sufficient cell attachment and expansion, which are essential in building biomimetic scaffolds. Read More

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http://dx.doi.org/10.1039/c8nr10384dDOI Listing

Adsorption of Cd and Cr ions from aqueous solutions by using residue of waste as promising low-cost adsorbent.

Heliyon 2019 Mar 7;5(3):e01287. Epub 2019 Mar 7.

Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

Recently, a great attention has been given for applying a low-cost and effective adsorbents instead of expensive and dangerous chemical materials as a promising approach to treat wastewater. In this work, residue powder of brown macroalga (RPG), after extracting most of its active components by 70% methanol, was used as an adsorbent material for wastewater treatment. This work also reduces the costs of residue disposal. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475646PMC

primarily forages in residential areas in Kandal, Cambodia.

Ecol Evol 2019 Apr 13;9(7):4181-4191. Epub 2019 Mar 13.

Institut Pasteur du Cambodge Phnom Penh Cambodia.

Bats are the second most species-rich Mammalian order and provide a wide range of ecologically important and economically significant ecosystem services. Nipah virus is a zoonotic emerging infectious disease for which pteropodid bats have been identified as a natural reservoir. In Cambodia, Nipah virus circulation has been reported in , but little is known about the spatial distribution of the species and the associated implications for conservation and public health. Read More

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http://dx.doi.org/10.1002/ece3.5046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468066PMC

Hybridization and rapid differentiation after secondary contact between the native green anole () and the introduced green anole ().

Ecol Evol 2019 Apr 26;9(7):4138-4148. Epub 2019 Mar 26.

Department of Biological Sciences University of Rhode Island Kingston Rhode Island.

In allopatric species, reproductive isolation evolves through the accumulation of genetic incompatibilities. The degree of divergence required for complete reproductive isolation is highly variable across taxa, which makes the outcome of secondary contact between allopatric species unpredictable. Since before the Pliocene, two species of lizards, and , have been allopatric, yet this period of independent evolution has not led to substantial species-specific morphological differentiation, and therefore, they might not be reproductively isolated. Read More

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http://dx.doi.org/10.1002/ece3.5042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468060PMC

Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber.

Toxicol Res 2019 Apr 15;35(2):119-129. Epub 2019 Apr 15.

BK21Plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon, Korea.

As the use of cosmetics has greatly increased in a daily life, safety issues with cosmetic ingredients have drawn an attention. Drometrizole [2-(2'-hydroxy-5'-methylphenyl)benzotriazole] is categorized as a sunscreen ingredient and is used in cosmetics and non-cosmetics as a UV light absorber. No significant toxicity has been observed in acute oral, inhalation, or dermal toxicity studies. Read More

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http://dx.doi.org/10.5487/TR.2019.35.2.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467354PMC

Addressing the rising rates of gonorrhea and drug-resistant gonorrhea: There is no time like the present.

Can Commun Dis Rep 2019 Feb 7;45(2-3):54-62. Epub 2019 Feb 7.

Bacterial Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.

Increasing rates of gonococcal (GC) infection and antimicrobial resistant (AMR) GC, are a serious public health concern for Canada and around the world. Previously recommended treatments are ineffective against many of the gonorrhea strains circulating today. The current recommendation for combination therapy is now being threatened by globally emerging and increasingly resistant strains. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
Publisher Site
http://dx.doi.org/10.14745/ccdr.v45i23a02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461120PMC
February 2019
1 Read

Updated NACI recommendations for measles post-exposure prophylaxis.

Can Commun Dis Rep 2018 Sep 6;44(9):226-230. Epub 2018 Sep 6.

Public Health Agency of Canada, Centre for Immunization and Respiratory Infectious Diseases, Ottawa, ON.

Background: Human immune globulin (Ig) products are currently recommended as post-exposure prophylaxis (PEP) for measles in certain susceptible groups. However, successful measles vaccination programs in North America have led to low circulation of measles virus and most blood donors now have vaccine-derived immunity. Concurrently, the concentrations of anti-measles antibodies in human Ig products have shown trends of gradual decline and previously recommended doses and routes of administration may no longer be optimally protective. Read More

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http://dx.doi.org/10.14745/ccdr.v44i09a07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449113PMC
September 2018

Summary of the NACI Seasonal Influenza Vaccine Statement for 2018-2019.

Can Commun Dis Rep 2018 Jun 7;44(6):123-128. Epub 2018 Jun 7.

Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Background: There are many different influenza vaccines authorized for use in Canada and new evidence on influenza and vaccines is emerging all the time. The National Advisory Committee on Immunization (NACI) provides recommendations annually regarding seasonal influenza vaccines to the Public Health Agency of Canada (PHAC).

Objective: To summarize the NACI recommendations regarding the use of seasonal influenza vaccines for the 2018-2019 influenza season in light of two NACI reviews conducted on 1) the risk of serious influenza-related complications in children and adults with neurologic and neurodevelopment conditions and 2) the efficacy/effectiveness of high-dose and adjuvanted inactivated influenza vaccines in persons 65 years of age and older. Read More

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Factors Affecting the Absorption of Midazolam to the Extracorporeal Membrane Oxygenation Circuit.

Acta Med Okayama 2019 Apr;73(2):101-107

Department of Emergency and Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Read More

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http://dx.doi.org/10.18926/AMO/56645DOI Listing
April 2019
1 Read

Phylogeography of the Neotropical epiphytic orchid, Brassavola nodosa: evidence for a secondary contact zone in northwestern Costa Rica.

Heredity (Edinb) 2019 Apr 23. Epub 2019 Apr 23.

Department of Plant Biology, University of Georgia, Athens, GA, 30602, USA.

Spatial patterns of genetic variation can reveal otherwise cryptic evolutionary and landscape processes. In northwestern Costa Rica, an approximately concordant genetic discontinuity occurs among populations of several plant species. We conducted phylogeographic analyses of an epiphytic orchid, Brassavola nodosa, to test for genetic discontinuity and to explore its underlying causes. Read More

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http://dx.doi.org/10.1038/s41437-019-0218-yDOI Listing

Biological activity of Dittrichia viscosa (L.) Greuter extracts against adult Sitophilus granarius (L.) (Coleoptera, Curculionidae) and identification of active compounds.

Sci Rep 2019 Apr 23;9(1):6429. Epub 2019 Apr 23.

Department of the Sciences of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71100, Foggia, Italy.

Dittrichia viscosa (L.) Greuter, a perennial weed of the Mediterranean area, was reported to be source of active substances. Here, by means of both ingestion and contact assays, the biological activity of three different extracts (n-hexane, methanol, and distilled water) of D. Read More

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http://dx.doi.org/10.1038/s41598-019-42886-4DOI Listing

Functional Printing of Conductive Silver-Nanowire Photopolymer Composites.

Sci Rep 2019 Apr 23;9(1):6465. Epub 2019 Apr 23.

Institut für Nanostruktur- und Festkörperphysik, Center for Free Electron Laser Science (CFEL), Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.

We investigated the fabrication and functional behaviour of conductive silver-nanowire-polymer composites for prospective use in printing applications. Silver-nanowires with an aspect ratio of up to 1000 were synthesized using the polyol route and embedded in a UV-curable and printable polymer matrix. Sheet resistances in the composites down to 13 Ω/sq at an optical transmission of about 90% were accomplished. Read More

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http://dx.doi.org/10.1038/s41598-019-42841-3DOI Listing

Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes.

Nat Commun 2019 Apr 23;10(1):1842. Epub 2019 Apr 23.

Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.

The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies for complex diseases. Its application for genetic and epigenetic therapies in humans raises concerns over immunogenicity of the bacterially derived Cas9 protein. Here we detect antibodies to Streptococcus pyogenes Cas9 (SpCas9) in at least 5% of 143 healthy individuals. Read More

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http://dx.doi.org/10.1038/s41467-019-09693-xDOI Listing

Nanoprinting organic molecules at the quantum level.

Nat Commun 2019 Apr 23;10(1):1880. Epub 2019 Apr 23.

Laboratory of Thermodynamics in Emerging Technologies, ETH Zürich, Sonneggstrasse 3, 8092, Zürich, Switzerland.

Organic compounds present a powerful platform for nanotechnological applications. In particular, molecules suitable for optical functionalities such as single photon generation and energy transfer have great promise for complex nanophotonic circuitry due to their large variety of spectral properties, efficient absorption and emission, and ease of synthesis. Optimal integration, however, calls for control over position and orientation of individual molecules. Read More

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http://dx.doi.org/10.1038/s41467-019-09877-5DOI Listing

The extracellular matrix protects Bacillus subtilis colonies from Pseudomonas invasion and modulates plant co-colonization.

Nat Commun 2019 Apr 23;10(1):1919. Epub 2019 Apr 23.

Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento de Microbiología, Universidad de Málaga, Bulevar Louis Pasteur 31 (Campus Universitario de Teatinos), 29071, Málaga, Spain.

Bacteria of the genera Pseudomonas and Bacillus can promote plant growth and protect plants from pathogens. However, the interactions between these plant-beneficial bacteria are understudied. Here, we explore the interaction between Bacillus subtilis 3610 and Pseudomonas chlororaphis PCL1606. Read More

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http://dx.doi.org/10.1038/s41467-019-09944-xDOI Listing

Ceramides bind VDAC2 to trigger mitochondrial apoptosis.

Nat Commun 2019 Apr 23;10(1):1832. Epub 2019 Apr 23.

Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabrück, 49076, Osnabrück, Germany.

Ceramides draw wide attention as tumor suppressor lipids that act directly on mitochondria to trigger apoptotic cell death. However, molecular details of the underlying mechanism are largely unknown. Using a photoactivatable ceramide probe, we here identify the voltage-dependent anion channels VDAC1 and VDAC2 as mitochondrial ceramide binding proteins. Read More

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http://dx.doi.org/10.1038/s41467-019-09654-4DOI Listing

RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36.

Nat Commun 2019 Apr 23;10(1):1855. Epub 2019 Apr 23.

Department of Biophysics, Johns Hopkins University, Baltimore, MD, 21218, USA.

DHX36 is a DEAH-box helicase that resolves parallel G-quadruplex structures formed in DNA and RNA. The recent co-crystal structure of DHX36 bound G4-DNA revealed an intimate contact, but did not address the role of ATP hydrolysis in G4 resolving activity. Here, we demonstrate that unlike on G4-DNA, DHX36 displays ATP-independent unfolding of G4-RNA followed by ATP-dependent refolding, generating a highly asymmetric pattern of activity. Read More

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http://dx.doi.org/10.1038/s41467-019-09802-wDOI Listing

Towards super-clean graphene.

Nat Commun 2019 Apr 23;10(1):1912. Epub 2019 Apr 23.

Center for Nanochemistry, Beijing Science and Engineering Center for Nanocarbons, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, P. R. China.

Impurities produced during the synthesis process of a material pose detrimental impacts upon the intrinsic properties and device performances of the as-obtained product. This effect is especially pronounced in graphene, where surface contamination has long been a critical, unresolved issue, given graphene's two-dimensionality. Here we report the origins of surface contamination of graphene, which is primarily rooted in chemical vapour deposition production at elevated temperatures, rather than during transfer and storage. Read More

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http://dx.doi.org/10.1038/s41467-019-09565-4DOI Listing

Counselling-based psychosocial intervention to improve the mental health of abused pregnant women: a protocol for randomised controlled feasibility trial in a tertiary hospital in eastern Nepal.

BMJ Open 2019 Apr 23;9(4):e027436. Epub 2019 Apr 23.

School of Nursing and Midwifery, Griffith University, Loganlea, Queensland, Australia.

Introduction: The strong correlation between domestic and family violence (DFV) and mental health has been well documented in studies. Pregnancy is a period when both DFV and mental distress tend to occur and/or accentuate. Although limited, available evidence from developed countries has shown continual support and education as psychological first aid that can reduce DFV and improve mental health. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027436DOI Listing

Simple semi-permanent blockade against rigid varus foot in a case with spasticity: possible practical benefits in ambulatory adults.

BMJ Case Rep 2019 Apr 23;12(4). Epub 2019 Apr 23.

Department of Rehabilitation Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.

A 55-year-old ambulatory woman with hemiplegia and varus foot deformity had several problems in her daily life, including load pain and stance instability in the affected foot, easy fatigue of the non-paralysed leg, low back pain, neck stiffness and rapid shoe-rubber wear on the deformed side. We began repeated focal blockades using botulinum toxin to the tibialis posterior muscle to control varus spasticity. Distant influences presenting in the whole body were relieved soon after the first blockade, and shoe wear also stopped. Read More

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http://dx.doi.org/10.1136/bcr-2018-227732DOI Listing

Preliminary results of the tribological performance of new modular temporary knee spacer antibiotic-impregnated.

J Mech Behav Biomed Mater 2019 Apr 17;95:205-209. Epub 2019 Apr 17.

G21 S.r.l., San Possidonio, Modena, Italy.

Purpose: Although total knee arthroplasty is one of the most successful and consolidated surgical procedure, the infection rate is still elevate. To treat infected knee arthroplasties, in the past years was approached a procedure that involved the implantation of an antibiotic-loaded temporary spacer. This spacer helps maintain an appropriate soft tissue envelope and the patients are able to walk during the interim period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17516161193039
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http://dx.doi.org/10.1016/j.jmbbm.2019.04.009DOI Listing
April 2019
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Far-field contributions in multi-electrodes atrial recordings blur distinction between anatomical and functional reentries and may cause imaginary phase singularities - A computational study.

Comput Biol Med 2019 Mar 14;108:276-287. Epub 2019 Mar 14.

Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia and the most important cause of embolic stroke, requiring new technologies for its better understanding and therapies. Recent approaches to map the electrical activity during AF with multi-electrode systems aim at localizing patient-specific ablation targets of reentrant patterns. However, there is a critical need to determine the accuracy of those mapping systems. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.02.022DOI Listing

Arsenic and trace metals in a large reservoir: Seasonal and spatial variations, source identification and risk assessment for both residential and recreational users.

Authors:
Memet Varol

Chemosphere 2019 Apr 17;228:1-8. Epub 2019 Apr 17.

Malatya Turgut Özal University, Faculty of Fisheries, Malatya, Turkey. Electronic address:

The Keban Dam Reservoir in Turkey is an internationally important reservoir, because it is located on the Euphrates River, which is an important transboundary river. Water samples were seasonally collected from 11 sampling sites on the reservoir between autumn 2014 and summer 2015. Spatial and seasonal variations, possible sources and health risks of dissolved trace metals (TMs) were investigated. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.126DOI Listing

A pore-scale investigation of heavy crude oil trapping and removal during surfactant-enhanced remediation.

J Contam Hydrol 2019 Mar 20. Epub 2019 Mar 20.

Department of Geological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.

The presence of nonaqueous phase liquid (NAPL) in the subsurface presents significant challenges for soil and groundwater remediation. In particular, heavy crude oil, coal tar and/or bitumen present unique difficulties for removal and cleanup due to associated high viscosities, low aqueous solubilities, and limited mobility extraction potential. Although surfactant-enhanced aquifer remediation (SEAR) techniques have shown some promise for source removal, overall remediation (mobilization) performance will depend significantly on interfacial effects between the fluid and solid phases. Read More

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http://dx.doi.org/10.1016/j.jconhyd.2019.03.003DOI Listing