296,497 results match your criteria Contact Granulomas
Domest Anim Endocrinol 2018 Nov 3;67:1-10. Epub 2018 Nov 3.
Department of Morphology and Function, CIISA- Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Prostaglandin E (PGE) has contradictory effects in many organs. It may have proinflammatory, anti-inflammatory, or anti-fibrotic roles, depending on the type of receptors to which it binds. By signaling through its receptors EP2 and EP4, PGE mediates anti-inflammatory and anti-fibrotic actions. Read More
Water Res 2018 Nov 14;149:596-606. Epub 2018 Nov 14.
State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; National Engineering Laboratory for VOCs Pollution Control Material & Technology, University of Chinese Academy of Sciences, Beijing, 101408, China. Electronic address:
Wastewater treatment plants (WWTPs) are major sources of airborne bacteria, which could pose health risks to WWTP workers and surrounding residents. In this study, air samples were collected from various treatment facilities of a typical WWTP. Community compositions of airborne bacteria were identified by high-throughput sequencing technique. Read More
Gait Posture 2018 Nov 20;68:227-231. Epub 2018 Nov 20.
Monash University, School of Primary and Allied Health Care, Frankston, VIC, 3199, Australia; Peninsula Health, Allied Health, 4 Hastings Rd, Frankston, VIC, 3199, Australia.
Background: There remains a substantial lack of evidence to support the use of foot orthoses as a conservative treatment option for idiopathic toe walking (ITW). Encouraging heel contact during gait is one of the primary goals of most interventions in paediatric ITW.
Research Question: Does the combined treatment of high-top boots and orthoses increase the number of heel contacts during gait and change spatio-temporal gait parameters?
Methods: This within subject designed randomised controlled trial recruited fifteen children diagnosed with ITW (n = 10 males). Read More
Fish Shellfish Immunol 2018 Dec 3. Epub 2018 Dec 3.
State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory of Improved Variety Reproduction in Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. Electronic address:
Nervous necrosis virus (NNV) causes viral nervous necrosis (VNN), a disease that leads to almost 100% mortality among larvae and juvenile fish, severely affecting the aquaculture industry. VNN vaccines based on inactivated viruses or virus-like particles (VLPs) are unsuitable for fish fry with immature adaptive immune systems. Here, we applied an anti-NNV strategy based on affinity peptides (AFPs). Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Department of Biomedical Engineering, Near East University, Nicosia, P. O. Box: 99138, North Cyprus via Mersin 10, Turkey; Tissue Engineering and Biomaterials Research Centre, Near East University, P. O. Box: 99138, North Cyprus via Mersin 10, Turkey.
Poly(N-hydroxy ethyl acrylamide) was grafted onto chitosan in aqueous acidic medium using potassium per sulphate initiator to obtain polymer surfaces with blood compatibility for potential biomedical applications. Thermally cross-linked products were obtained upon drying at 60 °C overnight. Chemically cross-linked films were prepared using methylene bis acrylamide (MBA) cross-linker. Read More
Am J Med 2018 Dec 3. Epub 2018 Dec 3.
Center for Bioethics and Social Science in Medicine, University of Michigan, Ann Arbor, MI; Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI. Electronic address:
Background: Peri-procedural antithrombotic medication management is a complex, often confusing process for patients and their providers. Communication difficulties often lead to suboptimal medication management resulting in delayed or cancelled procedures.
Methods: We conducted telephone surveys with patients taking chronic antithrombotic medications who had recently undergone an endoscopy procedure. Read More
Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):410-413. Epub 2018 Nov 30.
Instituto Mexicano del Seguro Social, Hospital General de Zona No. 71, Departamento de Medicina Interna. Veracruz, Veracruz, México
In this article we describe the main transmission mechanisms of the Zika virus, from those already known, such as zoonotic and anthroponotic transmission of the virus, perinatal, occupational transmission, by blood products and by sexual contact. Given the possibility of person-to-person transmission, some measures of attention are proposed as the necessary studies are advanced to confirm or discard it. Read More
Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.
Purpose: To compare the influence of ultraviolet (UV) irradiation and cold atmospheric pressure plasma (CAP) treatment on surface structure, surface chemistry, cytocompatibility, and cell behavior on zirconia in vitro.
Materials And Methods: Zirconia samples (TZ-3YSBE) were treated by UV irradiation, oxygen plasma, or argon plasma for 12 minutes each and compared with the nontreated samples. Surface analysis was conducted using scanning electron microscopy, roughness analysis, and x-ray photoelectron spectroscopy. Read More
Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.
Purpose: The design and surface features of dental implants substantially affect the healing and remodeling of adjacent bones. This study aimed to investigate the impact of design and surface on bone regeneration using implants of two different pitches, each with three different surface features.
Materials And Methods: Custom-manufactured titanium implants (length, 10 mm; diameter, 3. Read More
PLoS One 2018 6;13(12):e0208430. Epub 2018 Dec 6.
Swine Technical Services, Zoetis, Parsippany, New Jersey, United States of America.
The trial objective was to compare the performance and animal health parameters of pigs raised according to one of 3 antibiotic (AB) protocols: standard AB medication consisting of mass treatment on days 4 and 21 and judicious AB therapy given therapeutically thereafter as group medication in water and feed or by individual injection (group T1, N = 702); modified AB medication identical to group T1 but with mass treatment only on day 4 and without subsequent therapeutic feed medication (group T2, N = 675); or an antibiotic-free (ABF) regimen (group T3, N = 702). All pigs were vaccinated with a modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine 3 days after weaning. Using a seeder pig model to mimic endemic field infection dynamics, pigs were contact-challenged with virulent PRRSV lineage 1 strain 174 four weeks after vaccination. Read More
PLoS One 2018 6;13(12):e0207459. Epub 2018 Dec 6.
De la Préhistoire à l'Actuel, Culture, Environnement, Anthropologie-UMR 5199, CNRS, Université de Bordeaux, Allée Geoffroy Saint-Hilaire, CS, Pessac Cedex, France.
The compilation of archaeological and genetic data for ancient European human groups has provided persuasive evidence for a complex series of migrations, population replacements and admixture until the Bronze Age. If the Bronze-to-Iron Age transition has been well documented archaeologically, ancient DNA (aDNA) remains rare for the latter period and does not precisely reflect the genetic diversity of European Celtic groups. In order to document the evolution of European communities, we analysed 45 individuals from the Late Iron Age (La Tène) Urville-Nacqueville necropolis in northwestern France, a region recognized as a major cultural contact zone between groups from both sides of the Channel. Read More
Med J Aust 2018 Dec;209(11):495-500
Oxford University, Oxford, United Kingdom.
Objectives: To describe the patterns of alcohol use in James Bond movies over six decades.
Design: Film content analysis.
Setting: Wide range of international locations in 24 James Bond movies (Eon Productions series, 1962-2015). Read More
J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.
Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu, 41940, Republic of Korea.
The hydrophilicity of bone graft material generally used as a carrier can play an important role in regulating bone morphogenetic protein (BMP) expression at the bone graft site. The hydrophilicity, altering physicochemical properties, and enhancing biological capabilities, can be increased via surface modification through ultraviolet (UV) photofunctionalization and the effect on de novo osteogenesis could be further improved. Therefore, this study aimed to assess the effects of UV-irradiated TiO -coated hydroxyapatite (HA) in combination with rhBMP-2 on bone regeneration in rabbit calvarial defects. Read More
ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.
Superhydrophobic electromagnetic interference (EMI) shielding textile (EMIST) is of great significance to the safety and long-term service of all-weather outdoor equipment. However, it is still challenging to achieve long-term durability and stability under external mechanical deformations or other harsh service conditions. Herein, by designing and implementing silver nanowire (AgNW) networks and a superhydrophobic coating onto a commercial textile, we demonstrate a highly robust superhydrophobic EMIST. Read More
Proteins 2018 Dec 6. Epub 2018 Dec 6.
Department of Bioinformatics, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
To understand the folding mechanism of a protein is one of the goals in bioinformatics study. Nowadays, it is enigmatic and difficult to extract folding information from amino acid sequence by using standard bioinformatics techniques or even experimental protocols which can be time consuming. To overcome these problems, we aim to extract the initial folding unit for titin protein (Ig and fnIII domains) by means of inter-residue average distance statistics, Average Distance Map (ADM) and contact frequency analysis (F-value). Read More
J Vet Intern Med 2018 Dec 6. Epub 2018 Dec 6.
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York.
Background: A novel equine parvovirus (EqPV-H) was recently discovered in the equine liver with Theiler's disease.
Objectives: To determine the prevalence of EqPV-H infection in naturally occurring Theiler's disease cases and in-contact horses in the absence of historical equine biologic product administration.
Animals: Ten cases of Theiler's disease from 6 separate properties were included in the study, based on the criteria of acute onset of clinical signs of liver failure with laboratory or histopathologic findings characteristic of Theiler's disease and no history of receiving an equine biologic product within the preceding 4 months. Read More
Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.
Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.
Background: The aim of this study was to examine the influence of B-scan averaging on choroidal thickness using wide-field enhanced-depth imaging optical coherence tomography.
Methods: Six high-resolution trans-foveal horizontal enhanced-depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B-scans, using the automated real-time image averaging and follow-up features of a Spectralis device. The impact of B-scan averaging on regional measures of wide-field choroidal thickness (across macular and peripheral regions) and their accuracy was investigated, assuming that averaging 100 B-scans would provide the most accurate estimate of choroidal thickness. Read More
Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.
Department of Dermatology, Hospital Universitario Príncipe de Asturias, Madrid, Spain.
Upper eyelid gold weight implants are an established tool in the symptomatic treatment of lagophthalmos, the inability to close your eyes completely. Complications associated to this procedure are infrequent. When noted, non-infectious inflammatory reactions corresponding to type IV hypersensitivity reactions are resolved with the removal of the implant. Read More
Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.
University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.
Background: Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on prevalence of contact allergies to the European baseline series; overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.
Objective: To determine prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD). Read More
J Med Primatol 2018 Dec 6. Epub 2018 Dec 6.
Departamento de Patologia e Clínica Veterinária, Universidade Federal Fluminense, Niteroi, RJ, Brazil.
Background: The Atlantic Forest where the animals were captured is surrounded by residences, so this close contact could favor the presence of disease-transmitting pathogens, putting the local population at risk. For these and other factors, it is important to perform laboratory tests enabling the performance of important diagnoses.
Methods: Blood samples of 268 golden-headed lion tamarins (Leontopithecus chrysomelas) inhabiting an Atlantic Forest area in Rio de Janeiro, Brazil, were processed for accessing age and sex influence in hematological parameters and to establish normative hematology values. Read More
J Cell Physiol 2018 Dec 5. Epub 2018 Dec 5.
Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Lung cancer (LC) is the most common type of cancer and the second cause of death worldwide in men and women after cardiovascular diseases. Non-small-cell lung cancer (NSCLC) is the most frequent type of LC occurring in 85% of cases. Developing new methods for early detection of NSCLC could substantially increase the chances of survival and, therefore, is an urgent task for current research. Read More
J Youth Adolesc 2018 Dec 5. Epub 2018 Dec 5.
Department of Psychology, University of California, Los Angeles, CA, 90095-1521, USA.
Cross-ethnic friendships are linked to a range of positive outcomes in adolescence, but have been shown to be lower quality and less stable than same-ethnic friendships. The current study examined how classroom diversity and out-of-school contact contribute to these relational differences between cross-and same-ethnic friendships. Multilevel analyses were conducted on a sample of 9,171 classroom-based friends nested within 4,333 ethnically diverse sixth grade students (54% female; 32% Latino, 20% White, 14% East/Southeast Asian, 12% African American, 14% Multiethnic, 8% Other ethnic). Read More
Chem Soc Rev 2018 Dec 6. Epub 2018 Dec 6.
Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea and Institute of Chemical Processing (ICP), Seoul National University, Seoul 08826, Republic of Korea.
Highly conductive and intrinsically stretchable electrodes are vital components of soft electronics such as stretchable transistors and circuits, sensors and actuators, light-emitting diode arrays, and energy harvesting devices. Many kinds of conducting nanomaterials with outstanding electrical and mechanical properties have been integrated with elastomers to produce stretchable conductive nanocomposites. Understanding the characteristics of these nanocomposites and assessing the feasibility of their fabrication are therefore critical for the development of high-performance stretchable conductors and electronic devices. Read More
Nanoscale 2018 Dec 6. Epub 2018 Dec 6.
Hunan Key Laboratory for Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083, P. R. China. and Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627, USA.
One-dimensional semiconducting SnO2 nanowires with wide bandgaps are promising candidates to build many important optoelectronic devices. Because building these devices involves the assembly of nanowires into complex structures, manipulation of the active materials needs to be done with high spatial precision. In this paper, an optical tweezer system, comprising a spatial light-modulator, a microscope, and optical elements, is used to individually trap, transfer, and assemble SnO2 nanowires into two-terminal photodetectors in a liquid environment. Read More
Data Brief 2018 Dec 7;21:1858-1860. Epub 2018 Nov 7.
Siberian Forest Research Station, 5a/2 Mechanization Street, 625017 Tyumen, Russia.
This data article is related to the research articles entitled "The RING for gypsy moth control: topical application of fragment of its nuclear polyhedrosis virus anti-apoptosis gene as insecticide" (Oberemok et al., 2016), "Molecular alliance of multiple nucleopolyhedrovirus and a short unmodified antisense oligonucleotide of its anti-apoptotic IAP-3 gene: a novel approach for gypsy moth control" (Oberemok et al., 2017), and "Topical treatment of LdMNPV-infected gypsy moth caterpillars with 18 nucleotides long antisense fragment from LdMNPV IAP-3 gene triggers higher levels of apoptosis in infected cells and mortality of the pest" (Oberemok et al. Read More
Technology (Singap World Sci) 2018 Jun 29;6(2):67-74. Epub 2018 Jun 29.
Department of Biomedical Engineering, Rutgers, the State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA.
Allergic contact dermatitis (ACD) is an inflammatory disease that impacts 15-20% of the general population and accurate screening methods for chemical risk assessment are needed. However, most approaches poorly predict pre- and pro-hapten sensitizers, which require abiotic or metabolic conversion prior to inducing sensitization. We developed a tri-culture system comprised of MUTZ-3-derived Langerhans cells, HaCaT keratinocytes, and primary dermal fibroblasts to mimic the cellular and metabolic environments of skin sensitization. Read More
Front Cardiovasc Med 2018 21;5:168. Epub 2018 Nov 21.
School of Human Nutrition, McGill University, Ste. Anne de Bellevue, QC, Canada.
The heart is made up of an ordered amalgam of cardiac cell types that work together to coordinate four major processes, namely energy production, electrical conductance, mechanical work, and tissue remodeling. Over the last decade, a large body of information has been amassed regarding how different cardiac cell types respond to cellular stress that affect the functionality of their elaborate intracellular membrane networks, the cellular reticular network. In the context of the heart, the manifestations of stress coping strategies likely differ depending on the coping strategy outcomes of the different cardiac cell types, and thus may underlie the development of distinct cardiac disorders. Read More
Cureus 2018 Sep 28;10(9):e3384. Epub 2018 Sep 28.
Neurosurgery, Riverside University Health System, Moreno Valley, USA.
Measuring the electrical potential of a neuron cell currently requires direct contact with the cell surface. This method requires invasive probing and is limited by the deflection of electricity from baseline. From a clinical perspective, the electrical potential of the brain's surface can only be measured to a depth of one centimeter using an electroencephalogram (EEG), however, it cannot measure much deeper structures. Read More
PeerJ 2018 27;6:e5859. Epub 2018 Nov 27.
Faculty of Mechanical Engineering, University of Ljubljana, Ljubljana, Slovenia.
Background: Remote photoplethysmography (rPPG) is a promising optical method for non-contact assessment of pulse rate (PR) from video recordings. In order to implement the method in real-time applications, it is necessary for the rPPG algorithms to be capable of eliminating as many distortions from the pulse signal as possible.
Methods: In order to increase the degrees-of-freedom of the distortion elimination, the dimensionality of the RGB video signals is increased by the wavelet transform decomposition using the generalized Morse wavelet. Read More
Environ Sci Nano 2018 15;2018(5):696-707. Epub 2018 Jan 15.
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA.
Exposures to high doses of manganese (Mn) via inhalation, dermal contact or direct consumption can cause adverse health effects. Welding fumes are a major source of manganese containing nanoparticles in occupational settings. Understanding the physicochemical properties of manganese-containing nanoparticles can be a first step in understanding their toxic potential following exposure. Read More
Antimicrob Resist Infect Control 2018 29;7:148. Epub 2018 Nov 29.
3Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON Canada.
Background: Surgically-managed fractures, particularly open fractures, are associated with high rates of surgical site infections (SSIs). To reduce the risk of an SSI, orthopaedic surgeons routinely clean open fracture wounds in the emergency department (ED) and then apply a bandage to the open wound. Prior to the surgical incision, it is standard practice to prepare the fracture region with an antiseptic skin solution as an additional SSI prevention strategy. Read More
Front Microbiol 2018 21;9:2818. Epub 2018 Nov 21.
Laboratorio de Micología Médica, UFI 11/25, Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Bilbao, Spain.
Candidiasis is a major cause of human morbidity and mortality. Human uterine cervical stem cells conditioned medium (hUCESC-CM) is obtained from stromal stem cells of the cervical transformation zone, which are in permanent contact with a wide array of potential vaginal pathogens. In previous reports we have found that hUCESC-CM has antitumor and antibacterial potential. Read More
Case Rep Dermatol 2018 Sep-Dec;10(3):238-246. Epub 2018 Oct 24.
Department of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.
Proctosedyl® and Proctomyxin® are two commonly prescribed hemorrhoid therapies. Their topical application to the perianal region may be complicated by a local allergic contact dermatitis and subsequent autoeczematization reaction. We present three cases of an autoeczematization (ID) reaction to varying topical allergens found in Proctosedyl®/Proctomyxin®. Read More
BMC Nurs 2018 29;17:50. Epub 2018 Nov 29.
School of Nursing, Tung Wah College, 31 Wylie Road, Homantin, Kowloon, Hong Kong.
Background: To adopt a healthy lifestyle is considered an essential component of nursing education. Self-rated health is a subjective assessment of health status and is consistent with objective health status. Previous studies have shown an association between self-rated health and engagement in a healthy lifestyle. Read More
Clin Optom (Auckl) 2018 8;10:119-127. Epub 2018 Nov 8.
DAVICH Optical Chain, Daechi-dong, Gangnam-gu, Seoul, South Korea.
Background: The purpose of this study is to investigate and compare spectacle and contact lens (CL) prescription trends, with an emphasis on astigmatic refractive error prescribing differences for patients who purchase spectacles or CLs in South Korea.
Methods: A retrospective study of patient records of a major optical chain in South Korea was conducted. De-identified data of age, gender, power of prescribed spectacles and/or CLs were extracted from the practice database. Read More
Int Med Case Rep J 2018 9;11:319-323. Epub 2018 Nov 9.
Department of Microbiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia,
Melioidosis, an infectious disease caused by , has recently gained importance as an emerging infectious disease in Indonesia. Reports of this infection in Indonesia are limited, although cases have been reported in Makassar, South Sulawesi. We report a case of cutaneous melioidosis caused by pan-drug-resistant, moderate biofilm-producer strain of in a diabetic patient. Read More
Int Med Case Rep J 2018 12;11:313-318. Epub 2018 Nov 12.
Department of Infectious Diseases, Regional Hospital of Bellinzona e Valli, 6500 Bellinzona, Ticino, Switzerland.
Tularemia is a zoonosis caused by the infection of (a gram-negative aerobic bacterium). Transmission to other animals or humans usually occurs through insect or tick bites, direct contact with a contaminated environment (mud or water), infected animals - mainly lagomorphs - or by ingesting undercooked meat or inhaling contaminated dust (hay or soil). This paper discusses the case of a 32-year-old man, who came to our Emergency Room presenting with persistent fever, inguinal lymphadenopathy, and an ulcer on his left lower limb on a linear morphoea lesion that had been there for some time. Read More
Clin Epidemiol 2018 13;10:1649-1655. Epub 2018 Nov 13.
Department of Digestive Diseases K, Bispebjerg Hospital, Copenhagen, Denmark.
Background: The Danish national screening program for colorectal cancer (CRC) consists of an immunochemical fecal occult blood test (iFOBT) followed by colonoscopy. The Danish Colorectal Cancer Screening Database (DCCSD) records data on the incidence of hospital-registered complications after colonoscopy. However, the validity of these data is unknown, and the incidence of complications is potentially underreported. Read More
Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.
Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Purpose: To assess the effect of type and severity of congenital color vision deficiency (CCVD) on depth perception.
Methods: Thirty-one male patients with a known diagnosis of CCVD were included in the study group and 31 age-matched healthy subjects in the control group. After standard ophthalmological examination including best corrected visual acuity (BCVA) testing with Snellen chart, slit-lamp examination, non-contact tonometry, and fundus examination, all patients underwent color perception testing with Hardy-Rand-Rittler (HRR) 4th edition pseudoisochromatic test plates and stereoacuity testing with Titmus stereo test plates. Read More
Ir Med J 2018 06 7;111(6):769. Epub 2018 Jun 7.
HSE Ambulance Service
Using telecommunications technology it would be possible to link a patient and paramedic to a Doctor in the Emergency Department (ED) at the point of first patient contact. A questionnaire-based study on telemedicine in the pre-hospital environment involving patients, paramedics, doctors and nurses in the ED, was performed to assess if they would want and accept telemedicine in pre-hospital emergency care. When asked 98. Read More
J Toxicol Sci 2018 ;43(12):741-749
Department of Dermatology, Tohoku University Graduate School of Medicine.
In all current in vitro skin sensitisation assays, DMSO is used to dissolve water-insoluble chemicals. However, our previous study suggested the superiority of the modified IL-8 Luc assay (mIL-8 Luc), in which X-VIVO 15 is used to dissolve chemicals, over the original assay using DMSO (oIL-8 Luc). In this study, to confirm the superiority of the mIL-8 Luc, we first increased the number of chemicals examined and demonstrated the superiority of the mIL-8 Luc, in which the mIL-8 Luc provided 87. Read More
J Toxicol Sci 2018 ;43(12):697-709
School of Food and Biological Engineering, Jiangsu University, China.
Silver nanoparticles (Ag-NPs) are known as a noble metal, and owing to their exclusive properties, their use is widespread in consumer products and they are mostly incorporated into food packaging and food contact products. The aim of this work was to evaluate the effects of direct ingestion of Ag-NPs through food to assess their toxicity effects on the growth and development of silkworms at different concentrations (1 mg·L to 100 mg·L), in addition to the examination of the distribution of Ag-NPs in the silkworm body and midgut histopathological analysis. RNA sequencing was performed to investigate the transcriptomic responses to Ag-NPs exposure. Read More
Proc Natl Acad Sci U S A 2018 Dec 5. Epub 2018 Dec 5.
Department of Pharmacology, University of Washington, Seattle, WA 98195;
Potency of drug action is usually determined by binding to a specific receptor site on target proteins. In contrast to this conventional paradigm, we show here that potency of local anesthetics (LAs) and antiarrhythmic drugs (AADs) that block sodium channels is controlled by fenestrations that allow drug access to the receptor site directly from the membrane phase. Voltage-gated sodium channels initiate action potentials in nerve and cardiac muscle, where their hyperactivity causes pain and cardiac arrhythmia, respectively. Read More
BMC Infect Dis 2018 Dec 5;18(1):623. Epub 2018 Dec 5.
School of Veterinary Science, Faculty of Science, University of Sydney, Camperdown, New South Wales, Australia.
Background: Salmonella is an important human pathogen in Australia and annual case rates continue to increase. In addition to foodborne exposures, cases have been associated with animal and contaminated environment contact. However, routine surveillance in Australia has tended to focus on humans and food, with no reported attempts to collate and compare Salmonella data from a wider range of potential sources of exposure. Read More
Aging Ment Health 2018 Dec 6:1-10. Epub 2018 Dec 6.
a Centre for Research in Ageing and Cognitive Health (REACH) , School of Psychology, University of Exeter , Exeter , United Kingdom.
Objectives: Poor social connections may be associated with poor cognition in older people who are not experiencing mental health problems, and the trajectory of this association may be moderated by cognitive reserve. However, it is unclear whether this relationship is the same for older people with symptoms of depression and anxiety. This paper aims to explore social relationships and cognitive function in older people with depression and anxiety. Read More
Biointerphases 2018 Dec 5;13(6):06E410. Epub 2018 Dec 5.
ANFF-Vic Biointerface Engineering Hub, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia.
Plasma polymers are often used in applications requiring aqueous immersion; therefore, it is important to understand how this exposure affects the physical and chemical properties of the films. Three different plasma polymer films were deposited at different distances from the electrode, and the film properties were characterized using contact angle, ellipsometry, and x-ray photoelectron spectroscopy. The film behaviors in aqueous solutions were studied via quartz crystal microbalance with dissipation (QCM-D). Read More
Nano Lett 2018 Dec 5. Epub 2018 Dec 5.
This paper studies the temperature-dependent transport properties of ultrathin black phosphorus (BP). We present measurements of BP Schottky-barrier (SB) metal-oxide-semiconductor field-effect-transistors (MOSFETs) with various channel lengths, constructed from a single BP sample with nanoscale uniformity in thickness and width. The electrical characterization reveals a reversal in the temperature dependence of drain current as a function of gate voltage. Read More
Nanomaterials (Basel) 2018 Dec 4;8(12). Epub 2018 Dec 4.
Department of Coatings and Polymeric Materials, North Dakota State University, Fargo, ND 58018, USA.
Corrosion and corrosion-induced damage have resulted mostly in malfunctions and sometimes even in failures of metallic structures, including oil and gas pipelines. In this study, new high-performance composite coatings were developed by incorporating nanoparticles in the polymer resins with applications to oil and gas pipelines. The graphene nanoplatelets under different concentrations were used to prepare the epoxy-based nanocomposites and were then evaluated through mechanical and electrical tests. Read More