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Am J Otolaryngol 2022 May 4;43(4):103482. Epub 2022 May 4.

Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing 100048, China.

Background: Although there are many treatments for laryngeal contact granuloma (LCG), some patients still fail treatment. Botulinum toxin A injection vocal cords may be a salvage therapy.

Objectives: To study the efficacy of thyroarytenoid botulinum toxin A injection for the treatment of refractory LCG. Read More

Eur J Immunol 2022 05 9;52(5):784-799. Epub 2022 Apr 9.

Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR).

Platelets regulate human inflammatory responses that lead to disease. However, the role of platelets in tuberculosis (TB) pathogenesis is still unclear. Here, we show that patients with active TB have a high number of platelets in peripheral blood and a low number of lymphocytes leading to a high platelets to lymphocytes ratio (PL ratio). Read More

Am J Ophthalmol Case Rep 2022 Jun 16;26:101489. Epub 2022 Mar 16.

Department of Ophthalmology and Optometry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: To describe a case of an immune-related adverse event associated with Atezolizumab therapy which was aggravated by ocular surgery.

Observations: A 59-year-old man treated with Atezolizumab for metastatic non-small-cell lung cancer developed a conjunctival hypertrophic lesion mistaken for metastatic tissue. Biopsy surgery induced fulminant and multifocal granulomatous conjunctival tissue growth and sterile corneal ulceration. Read More

Ocul Immunol Inflamm 2022 Feb 24:1-8. Epub 2022 Feb 24.

Department of Ophthalmology, Ondokuz Mayıs University, Samsun, Turkey.

Purpose: To report sarcoid-like uveitis with or without tubulointerstitial nephritis (TIN) during coronavirus disease 2019 (COVID-19) and to discuss diagnostic evaluation and treatment.

Methods: Detailed information on the subject's demographics, medical history, ophthalmic examination findings, and laboratory results were obtained from medical records. Fluorescein angiography (FA) and indocyanine green angiography (ICGA) images were evaluated. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Feb;36(2):101-104

Department of Pharyngology Laryngology & Phonosurgery Department of Otorhinolaryngology Head and Neck Surgery，the Sixth Medical Center of PLA General Hospital.

The aim of this study is to investigate the effect of surgical resection of idiopathic laryngeal contact granuloma on the follow-up treatment. From April 2014 to December 2019, the clinical data of 390 male patients with idiopathic laryngeal granuloma treated were analyzed retrospectively. The patients were divided into the group with history of surgical resection （172 patients） and the group without surgical resection history （218 patients）, and then both received the combined therapy. Read More

Indian J Tuberc 2022 Jan 9;69(1):58-64. Epub 2021 Mar 9.

Department of Radio Diagnosis, AIIMS, New Delhi, India.

Female genital tuberculosis (FGTB) is a common cause of infertility in developing countries. It can manifest as menstrual disturbances, infertility and pelvic masses.

Objective: To evaluate the role of computed tomography in diagnosis of female genital tuberculosis with tubo-ovarian (adnexal) masses. Read More

Microorganisms 2022 Jan 10;10(1). Epub 2022 Jan 10.

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus UAB, 08193 Bellaterra, Spain.

Voles are maintenance hosts of . In line with the goal to eradicate tuberculosis (TB) in livestock, the role of this mycobacteria needs to be assessed since it might interfere with current / surveillance strategies. To better understand the pathogenesis of TB in voles, an experimental infection model was set up to reproduce infection in laboratory Bank voles (). Read More

Dermatology 2021 Dec 30:1-8. Epub 2021 Dec 30.

Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Background: The frequency of tattoos varies from 10% to 30% across the population worldwide. The growing popularity of tattooing increases the number of cutaneous reactions connected with this procedure. As we have not found any previous studies in the literature concerning tattoo complications in Poland and other Eastern European countries, we believe this to be the first study of this kind. Read More

Medicine (Baltimore) 2021 Dec;100(51):e28305

Rheumatology Division - Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Abstract: The mortality rate of patients with anti-neutrophil cytoplasm antibody -associated vasculitis (AAV) is higher than the general population. To date, no studies have evaluated the factors associated with unfavorable outcomes in Brazilian patients, who represent a miscegenated population. Our objective was to identify clinical and laboratory features associated with mortality in Brazilian patients with AAV. Read More

Acta Med Port 2022 Mar 6;35(3):218-221. Epub 2021 Dec 6.

Serviço de Dermatologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.

Sarcoid granulomas can be found in a wide range of diseases and differentiating sarcoidosis from a sarcoid-like reaction may be a challenge. We present a woman with erythematoviolaceous papulonodular lesions located on the ears where piercings were placed. A skin biopsy showing an infiltrate of sarcoid and focal tuberculoid granulomas did not exclude sarcoidosis. Read More

Cureus 2021 Oct 14;13(10):e18782. Epub 2021 Oct 14.

Department of Internal Medicine IV, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.

Reported cases of Q fever in people living in urban areas after occasional contact with farm animals or infected pets such as dogs and cats have been increasing. The diagnosis of Q fever is usually laborious due to unspecific and variable clinical manifestations. The most common clinical presentation is an influenza-like illness with varying degrees of pneumonia and hepatitis. Read More

J Voice 2021 Oct 8. Epub 2021 Oct 8.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China. Electronic address:

Objective: Laryngeal contact granuloma (LCG) is a relatively uncommon disease with chronic inflammatory stimulation, and long-term reflux irritation is a vital factor for arytenoid cartilage calcification. Our investigation compared the severity of ipsilateral arytenoid cartilage calcification with the frequency of recurrence of LCG after surgical treatment.

Methods: A retrospective chart review of prospectively gathered data over five years from 327 patients, including 153 subjects without laryngeal lesions, were age- and sex-matched normal controls, 103 patients with various other vocal cord lesions were in the laryngeal lesion group and 71 LCG patients met the diagnostic criteria pathologically. Read More

Skin Appendage Disord 2021 Aug 13;7(5):393-396. Epub 2021 Apr 13.

Department of Dermatology, CHU UCL Namur - Sainte Elisabeth Hospital, Namur, Belgium.

Fish pedicures and/or fish manicures are treatments performed in spas involving the use of the living fish . In the last decade, the use of for cosmetic and therapeutic reasons has become increasingly popular. The patients are placed into a bath to control psoriasis, eczema, or other skin conditions, but there is no scientific proof of their effectiveness. Read More

Contact Dermatitis 2022 Jan 1;86(1):9-14. Epub 2021 Oct 1.

National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Background: Parents report that children with aluminium contact allergy and vaccination granulomas may react to aluminium-containing sunscreen following application.

Objectives: To evaluate whether contact dermatitis develops following repeated application of aluminium-containing sunscreens in children with aluminium sensitization and vaccination granulomas.

Methods: Sixteen children aged 2-9 years (mean age 5 years) with vaccination granulomas and a positive patch test reaction to aluminium chloride hexahydrate 2%/10% petrolatum completed a blinded repeated open application test (ROAT) with two daily applications of two sunscreens for 14 days. Read More

Curr Diabetes Rev 2022 ;18(4):46-55

Department of Human Pathology in Adult and Developmental Age, University of Messina, Messina, Italy.

Skin involvement is an overlooked aspect in the management of paediatric patients with type 1 diabetes. A comprehensive search of published literature using the PubMed database was carried out using the following key terms: "children," "pediatric/paediatric patients," "skin," "skin disorders," "type 1 diabetes." Dermatological side effects are frequently observed among diabetic children and adolescents. Read More

BMJ Case Rep 2021 Aug 13;14(8). Epub 2021 Aug 13.

Department of Paediatrics, Father Muller Medical College, Mangalore, Karnataka, India.

A 2-year-old female child from South India presented with persistent fever for 3 weeks, pallor and hepatosplenomegaly. There was no history of contact with tuberculosis (TB) and BCG scar was absent. Tests for TB (Mantoux and gastric aspirate) were negative. Read More

Respir Res 2021 Aug 9;22(1):224. Epub 2021 Aug 9.

Unit for Interstitial Lung Diseases, Department of Respiratory Diseases, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: Sarcoidosis most commonly affects lungs and intrathoracic lymph nodes, but any other organ can be involved. In epidemiological studies, many occupational and environmental exposures have been linked to sarcoidosis but their relationship with the disease phenotype has barely been studied.

Objective: To investigate how occupational and environmental exposures prior to diagnosis relate to organ involvement in patients with sarcoidosis METHODS: We retrospectively studied patients seen at a sarcoidosis clinic between 2017 and 2020. Read More

Int J Syst Evol Microbiol 2021 Aug;71(8)

Department of Biology, Université de Saint-Boniface, Winnipeg, Manitoba, Canada.

, , , , and are the only taxa from among ~121 species deemed potentially able to harbour diphtheria genes. Subsequently -gene bearing species may potentially produce diphtheria toxin, which is linked to fatal respiratory distress if a pharyngeal pseudomembrane is formed or toxaemia develops in those unimmunized or under-immunized. Detection of diphtheria toxin-producing species may also invoke a public health response and contact tracing. Read More

Indian J Ophthalmol Case Rep 2021 Jan-Mar;1(1):34. Epub 2020 Dec 31.

Department of Ophthalmology, NYU Langone Health, New York, USA.

Front Med (Lausanne) 2021 28;8:692060. Epub 2021 Jun 28.

Department of Dermatology, The Second Affiliated Hospital, Anhui Medical University, Hefei, China.

Dermoscopic features of cutaneous vascular anomalies have been reported, but the described features currently known are limited and not well-understood. The aim of this study is to comprehensively summarize and compare the dermoscopic features of the four different types of cutaneous vascular anomalies [infantile hemangiomas (IH), cherry angioma (CA), angiokeratomas (AK), and pyogenic granuloma (PG)] in the Chinese Han population. Dermoscopic features of 31 IH, 172 CA, 31 AK, and 45 PG were collected based on the contact non-polarized mode of dermoscopy at 20-fold magnification. Read More

Case Rep Pediatr 2021 7;2021:9994067. Epub 2021 Jun 7.

Department of Dermatology and Skin Sciences, University of British Columbia and Consultant Pediatric Dermatologist the BC Children's Hospital, Vancouver, British Columbia V6H 3V4, Canada.

Granuloma gluteale infantum is a rare complication of irritant contact dermatitis. For the treatment of granuloma gluteale infantum, the diaper area should be kept clean and dry and the source of skin irritation should be removed or mitigated. For those infants who fail to respond to the conservative management, the use of topical calcineurin inhibitors should be considered. Read More

BMC Anesthesiol 2021 06 14;21(1):170. Epub 2021 Jun 14.

Division of General Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, No. 386, Dazhong 1st Rd, Zuoying District, 81362, Kaohsiung, Taiwan.

Background: Transoral thyroidectomy can be performed using nasal or oral intubation. Recently, we encountered two cases of vocal cord granuloma that were suspected to result from intraoperative compression by the oral endotracheal tube.

Cases Presentation: Two women underwent transoral endoscopic thyroidectomy with oral endotracheal tubes fixed at the mouth angle. Read More

Immunol Lett 2021 07 2;235:15-21. Epub 2021 May 2.

Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, PR China. Electronic address:

Repeated exposure to fungi-contaminated dust can lead to multiple adverse effects on the lung, such as hypersensitivity pneumonitis, granuloma even irreversible fibrosis. 1,3-β-glucan, a major cell wall component of fungi, is considered as its exposure biomarker. Existing studies showed that a series of Th responses were involved in 1,3-β-glucan induced hypersensitivity pneumonitis, in which macrophages, Treg, and IL-10 producing B cells were reported to participate. Read More

Adv Biomed Res 2020 23;9:75. Epub 2020 Dec 23.

Department of Pediatrics, Pediatric Neurology Division, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Extrapulmonary tuberculosis (TB) is a well-recognized cause of pyrexia of unknown origin. However, clinical presentation of TB in children with isolated hematological abnormalities is extremely rare. Anemia, usually normocytic, normochromic, leukopenia, leukocytosis, thrombocytopenia, thrombocytosis, and monocytosis are more common complications of TB rather than pancytopenia. Read More

Head Neck Pathol 2021 Dec 26;15(4):1172-1184. Epub 2021 Apr 26.

Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, 02115, USA.

Background: Irritant contact stomatitis (ICS) and contact hypersensitivity stomatitis (CHS) are often caused by alcohol, flavoring agents and additives in dentifrices and foods, and contactants with high or low pH. A well-recognized contactant for ICS is Listerine™ mouthwash, while that for CHS is cinnamic aldehyde. However, many other flavoring agents and even smokeless tobacco are contactants that cause mucosal lesions that are entirely reversible. Read More

Joint Bone Spine 2021 Jul 7;88(4):105183. Epub 2021 Apr 7.

Rheumatology department, GHUPSSD, AP-HP, Bobigny, France; Inserm UMR 1125, Université Sorbonne Paris Nord, 93000 Bobigny, France. Electronic address:

Background: "Sarcoidosis-like" paradoxical reactions to Antitumor necrosis factor α (anti-TNFα) treatment have been reported. The clinical presentations are varied, most of the time, with a relatively typical picture of mediastinopulmonary involvement. More rarely, isolated granulomatous locations from various organs are described, leading to difficulties in diagnosis. Read More

Contact Dermatitis 2021 Apr 1. Epub 2021 Apr 1.

National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Aluminium contact allergy is mainly seen as granulomas following immunization with aluminium-adsorbed vaccines and contact allergy following epicutaneous exposure may be overlooked. To investigate the prevalence of aluminium allergy confirmed by patch testing, with no association with vaccination granulomas, and explore whether epicutaneous exposure to aluminium can contribute to allergic contact dermatitis. Two authors independently searched PubMed and MEDLINE (OVID) for case studies on contact allergy to aluminium proven by patch testing. Read More

Tech Innov Patient Support Radiat Oncol 2021 Jun 18;18:8-11. Epub 2021 Mar 18.

Instituto Brasileiro de Controle do Câncer - IBCC, Brazil.

Breast reconstructive surgery with silicone implants is routinely one of the techniques performed immediately after a mastectomy and before adjuvant radiotherapy. Implant shell degradation may result in gel bleeding that can trigger capsular disease. The silicone corpuscle in contact with the implant fibrous capsule can promote an inflammatory reaction, identified as silicone-induced granuloma which is, related to clinical complaints referred to as breast implant illness. Read More

World J Clin Cases 2021 Mar;9(8):1989-1995

Department of Otorhinolaryngology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China.

Background: Laryngeal contact granuloma (LCG) is difficult to treat and frequently associated with high persistence and recurrence, despite the availability of both surgical and pharmacological treatment options. An appropriate strategy is therefore needed to help patients with multiple recurrences of LCG to potentially avoid unnecess-ary surgery.

Case Summary: We describe the case of a 34-year-old male patient with recurrent LCG in which a good response was achieved through successful management of laryngophar-yngeal reflux disease using a combination pharmacotherapeutic regimen consisting of anti-reflux therapy, pepsin secretion inhibition, bile acid neutralization, and lifestyle modifications. Read More