Search Our Scientific Publications & Authors

Ned Tijdschr Geneeskd 2020 May 11;164. Epub 2020 May 11.

Erasmus MC, Rotterdam, afd. Dermatologie.

A 28-year-old woman was seen at our clinic with asymptomatic bumps in the eyebrows which arose 3 months after microblading, a cosmetic procedure to make the eyebrows appear fuller. Physical examination showed red-brown confluent papules. A skin biopsy revealed a non-necrotizing granulomatous reaction with sarcoid granulomas. Read More

Head Neck Pathol 2020 May 7. Epub 2020 May 7.

Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA.

A 47-year-old man presented to the otolaryngology service with complaint of 6 months of intermittent globus sensation. He reported constant throat clearing and subjective lowering of his voice. Flexible nasolaryngoscopy revealed a large pedunculated mass originating from the left vocal process of the arytenoid, lying superior to the vocal fold. Read More

J Cutan Pathol 2020 Apr 12. Epub 2020 Apr 12.

Department of Dermatology, University of California, San Francisco, California, USA.

Background: Granuloma annulare (GA) is a skin disorder of uncertain etiology. Patch (type) GA is an uncommon variant of GA with a paucity of data characterizing it. We describe the features of 23 cases of patch GA. Read More

Ann Dermatol Venereol 2020 Apr 7. Epub 2020 Apr 7.

Cabinet de dermatologie, 34, avenue d'Allemagne, 80000 Amiens, France.

Background: Collagen stimulators such as Ellansé® are soft tissue fillers able to induce nucleogenesis. We describe a case of eruptive foreign body granulomas following injection of Ellansé® that were successfully treated using methotrexate.

Case Report: A 47-year-old woman received injections of Ellansé® for the wrinkled aspect of her cheeks. Read More

Ned Tijdschr Geneeskd 2020 Mar 26;164. Epub 2020 Mar 26.

UMC Utrecht, afd. Keel-, Neus- en Oorheelkunde, Utrecht.

In addition to its mucosal pathology, sarcoidosis of the nose may cause a range of skin abnormalities and destruction of the osteocartilaginous structures of the nose. Clinical presentation can mimic other diseases and a biopsy is often necessary. We propose a classification of nasal sarcoidosis based on disease location to help with recognition of the symptoms and, subsequently, treatment. Read More

Contact Dermatitis 2020 Mar 27. Epub 2020 Mar 27.

National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Background: Aluminum contact allergy is mostly seen in children with vaccination granulomas, following immunization with aluminum-adsorbed childhood vaccines.

Objectives: To characterize a cohort of children with vaccination granulomas and aluminum allergy concerning early life conditions, exacerbating factors, avoidance behavior, treatments, and potential impact on quality of life.

Methods: A questionnaire study was conducted among 177 children aged 0 to 15 years with vaccination granulomas and aluminum allergy, and a reference group of 61 children aged 3 to 14 years with various types of dermatitis undergoing patch testing. Read More

Interdiscip Toxicol 2019 Oct 20;12(2):45-70. Epub 2020 Feb 20.

Department Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria.

Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. Read More

J Invest Dermatol 2020 Feb 22. Epub 2020 Feb 22.

Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA. Electronic address:

Langhans multinucleated giant cells (LGCs) are a specific type of multinucleated giant cell containing a characteristic horseshoe-shaped ring of nuclei that are present within granulomas of infectious etiology. Although cytokines that trigger macrophage activation (such as IFN-γ) induce LGC formation, it is not clear whether cytokines that trigger macrophage differentiation contribute to LGC formation. Here, we found that IL-15, a cytokine that induces M1 macrophage differentiation, programs human peripheral blood adherent cells to form LGCs. Read More

Endocr Metab Immune Disord Drug Targets 2020 Jan 28. Epub 2020 Jan 28.

Dermatology Section, Department of Medicine, University of Perugia, Perugia, Italy.

Background: Nickel is the most common cause of contact allergy in general population and the most frequently detected allergen in patients patch tested for suspected allergic contact dermatitis (ACD). Nickel Allergy: ACD from nickel is a typical type IV hypersensitivity. Nickel allergy is mostly caused by non-occupational exposure, such as jewelry and clothing decorations, metal tools, medical devices (mainly orthopedic and orthodontic implants, cardiovascular prosthesis), eyeglasses, utensils, keys, pigment for paint, cosmetics and food (mainly legumes, chocolate, salmon, peanuts). Read More

Acta Dermatovenerol Croat 2019 Dec;27(4):280-281

Luis Santiago, MD, Dermatology Department Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal;

Dear Editor, Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats, and humans are infected either through direct transmission from active lesions on infected animals or through contact with fomites (2). Orf is an occupational hazard and the population at risk includes shepherds, butchers, farmers, wool shearers, and veterinarians (2,3). Read More

Crit Rev Toxicol 2019 10 15;49(9):742-789. Epub 2020 Jan 15.

Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.

For a few years, mineral oils and their potential adverse health effects have been a constant issue of concern in many regulatory areas such as food, cosmetics, other consumer products, and industrial chemicals. Analytically, two fractions can be distinguished: mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). This paper aims at assessing the bioaccumulative potential and associated histopathological effects of MOSH as well as the carcinogenic potential of MOAH for consumer-relevant mineral oils. Read More

J Vet Diagn Invest 2020 Jan 17;32(1):147-151. Epub 2019 Dec 17.

Louisiana State University, Baton Rouge, LA (Ford).

We document a case of , a rare, zoonotic bacterium, in a white-tailed deer (WTD; ) in East Baton Rouge Parish, Louisiana. Grossly, the deer had fibrinous pleuropneumonia with yellow, mineralized nodules scattered throughout the lungs and extending to the pleura. The kidneys were enlarged and had numerous pale foci in the cortex. Read More

BMC Infect Dis 2019 Nov 21;19(1):983. Epub 2019 Nov 21.

Department of Dermatology, the Second Hospital of Jilin University, No. 218, Ziqiang street, Nanguan district, Changchun, 130000, China.

Background: Dermatophytosis is a fungal infectious disease caused by dermatophytes, which produce protease and keratinase to digest keratin, leading to the colonization, invasion, and infection of the stratum corneum of the skin, hair shafts, and nails. Trichophyton interdigitale belongs to Trichophyton mentagrophytes complex, which is the common pathogen causing dermatophytosis. Fungal keratitis, also called keratomycosis, is an infectious disease of cornea. Read More

Food Chem Toxicol 2020 Feb 18;136:110966. Epub 2019 Nov 18.

Mars Global Food Safety Center, Beijing, PR China.

Key issues around the evaluation of risks to humans from mineral oils in food and feedstuffs are discussed. MOHs (MOAH and MOSH) occur in food due to intentional use, contamination from environmental sources and during transport/processing, or through migration from food contact materials. Problems in setting and enforcing human health guidelines for MOH include uncertainty around MOH toxicity and the specialist expertise needed for analysis of complex food matrices. Read More

J Parasit Dis 2019 Dec 11;43(4):726-729. Epub 2019 Jun 11.

2Laboratório de Clinico, Universidade Vila Velha, Vila Velha, Brazil.

are mites commonly found within domestic feline hair stems. The infested animal presents an opaque fur with a "salt and pepper" aspect. The contamination may occur by direct contact with other infected animals or by fomites, and the main diagnostic tool is the direct examination of the fur. Read More

ORL J Otorhinolaryngol Relat Spec 2019;81(5-6):348-353. Epub 2019 Nov 6.

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objective: Despite the fact that there are many treatment alternatives, laryngeal contact granuloma has a high tendency of persistence, spontaneous disappearance without treatment, and recurrence. A comparison of the effects of conservative treatment and surgical therapy on laryngeal contact granuloma was made in a retrospective review.

Methods: A total of 124 patients with laryngeal contact granuloma were divided into 2 groups according to treatment: simple surgical excision (n = 36) and conservative treatment (n = 84). Read More

Vet Sci 2019 Oct 24;6(4). Epub 2019 Oct 24.

School of Veterinary Science and Marie Bashir Institute for Infectious Diseases and Biosecurity, Farm Animal Health, University of Sydney, Camden, NSW 2570, Australia.

The presence of a wildlife reservoir for complicates the eradication of bovine tuberculosis (BTB) from domestic cattle populations. For the BTB eradication program in Fiji, there is concern about the small Indian mongoose (), which is overabundant and in direct contact with cattle. Consequently, a survey of mongooses trapped on three BTB affected dairy farms led to necropsy of 85 mongooses during January-February 2017. Read More

Photodiagnosis Photodyn Ther 2020 Mar 17;29:101580. Epub 2019 Oct 17.

Istanbul Beyoglu Eye Education and Research Hospital, Turkey.

Choroidal granuloma is rarely seen as the first sign of tuberculosis(TB). Here we report a case of a 34-year old male with a choroidal mass which was associated with serous retinal detachment on EDI-OCT and the "contact sign" between the neurosensory retina and the retinal pigment epithelium. We analysed the macular microvascular features of tuberculoma with Optical Coherence Tomography Angiography(OCTA). Read More

J Voice 2019 Oct 15. Epub 2019 Oct 15.

Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, California. Electronic address:

Objective: Laryngeal contact granuloma is a disease of benign hypertrophic granulation tissue at the medial side of vocal process. Numerous studies of conservative and surgical management have reported effectiveness, yet optimal treatment has not been standardized. We compared primary and secondary outcomes of conservative and surgical treatment using endoscopic grading, Voice Handicap Index-10 (VHI-10), maximum phonation time (MPT), and recurrence rate. Read More

J Dtsch Dermatol Ges 2019 Oct 27;17(10):1039-1051. Epub 2019 Sep 27.

Department of Dermatology, University Hospital, Jena, Germany.

Eosinophilic dermatoses are a heterogeneous group of diseases, characterized by an eosinophil-rich infiltrate and/or degranulation of eosinophils. Blood eosinophilia may be an associated feature. Typical, albeit not specific histological findings include 'flame figures', which are caused by the accumulation of cationic proteins released by eosinophils and subsequent collagen denaturation. Read More

Front Vet Sci 2019 28;6:286. Epub 2019 Aug 28.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States.

Granulomas can "mimic" gliomas on magnetic resonance imaging (MRI) in human patients. The goal of this retrospective study was to report canine brain granulomas that were consistent with glioma based upon MRI, report their histologic diagnosis, and identify MRI criteria that might be useful to distinguish granuloma from glioma. Ten granulomas, initially suspected to be glioma based on MRI, were ultimately diagnosed as granulomatous meningoencephalomyelitis ( = 5), infectious granulomas ( = 3) or other meningoencephalitis ( = 2). Read More

J Innate Immun 2020 25;12(3):257-272. Epub 2019 Sep 25.

Immunology Unit, Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary,

Previously, a novel cell type, the multinucleated giant hemocyte (MGH) was identified in the ananassae subgroup of Drosophilidae. These cells share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. We were able to show that MGHs also differentiate in Zaprionus indianus, an invasive species belonging to the vittiger subgroup of the family, highly resistant to a large number of parasitoid wasp species. Read More

PLoS One 2019 19;14(9):e0221367. Epub 2019 Sep 19.

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Khorasan-e-Razavi, Iran.

Objective: Mycobacterium marinum causes a rare cutaneous disease known as fish tank granuloma (FTG). The disease manifestations resemble those associated with Cutaneous Leishmaniasis (CL). The aim of this study was to determine whether FTG was the cause of cutaneous lesions in patients who were referred to the Parasitology laboratory of Imam Reza Hospital in Mashhad to be investigated for CL. Read More

Pediatr Dermatol 2019 Nov 2;36(6):1012-1016. Epub 2019 Sep 2.

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

In this article, we report the sonographic features of vaccination granulomas in three children sensitized to aluminum. Although the recognition of the vaccination granuloma relies on the clinical examination, misdiagnosis is frequent, leading to distressful procedures or prolonged antibiotic administration. In all our cases, sonography revealed a teardrop-shaped echogenic central structure, suggesting the deposition of aluminum crystals along the route of administration with consequent subcutaneous degenerative changes, and a surrounding hypoechoic cap, which reflects the changeable inflammatory reaction and the granuloma formation. Read More

Exp Ther Med 2019 Aug 18;18(2):955-959. Epub 2019 Apr 18.

Department of Diabetic Foot Care, 'Prof. N. Paulescu' National Institute of Diabetes, 011233 Bucharest, Romania.

β-Blockers are a widely utilised class of medication. They have been in use for a variety of systemic disorders including hypertension, heart failure and intention tremors. Their use in dermatology has garnered growing interest with the discovery of their therapeutic effects in the treatment of haemangiomas, their potential positive effects in wound healing, Kaposi sarcoma, melanoma and pyogenic granuloma, and, more recently, pemphigus. Read More

World Neurosurg 2019 Nov 2;131:e454-e459. Epub 2019 Aug 2.

Department of Neurosurgery, Kyung Hee University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: Microvascular decompression (MVD) is the treatment of choice for hemifacial spasm (HFS), due to the high rate of complete resolution associated with MVD. However, some patients experience recurrent or persistent symptoms after surgery. In this study, we evaluated the causes of recurrence or failure based on our surgical experience with revision of MVD for HFS and analyzed the relationship between surgical outcomes and radiologic and intraoperative findings. Read More

Pan Afr Med J 2019 9;32:163. Epub 2019 Apr 9.

Service de Médecine Interne, Centre Hospitalier Aristide le Dantec, Dakar, Sénégal.

Tuberculosis of the cervix is rare and can mimick cervical cancer. Patients are paucisymptomatic and the disease is characterized by an insidious evolution, hence the delay in diagnosis. Common symptoms are non-specific contributing to therapeutic delay and increasing the risk of infertility which is perhaps inevitable. Read More

Am J Otolaryngol 2019 Sep - Oct;40(5):715-719. Epub 2019 Jun 28.

Department of Otorhinolaryngology Head and Neck Surgery, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai, PR China. Electronic address:

Objective: This study assessed the utility of narrow band imaging (NBI) in patients with symptoms of laryngopharyngeal reflux (LPR) and tried to quantitatively evaluate the signs found under the NBI Laryngoscope.

Methods: Patients with and without LPR symptoms completed reflux symptom index (RSI) questionnaires prior to enrolment. The throat was examined by standard white light endoscopy followed by NBI. Read More

Biomed Microdevices 2019 07 4;21(3):66. Epub 2019 Jul 4.

School of Medicine, Department of Dermatology, University of California, San Francisco, 90 Medical Center Way, Box 0989, Surge Building, Room 110, San Francisco, CA, 94143-0989, USA.

Developed within the last few decades, microneedles (MNs) have only recently seen wide-scale use among the general population, especially in the area of cosmetics. With the FDA only starting to regulate microneedling devices and the many new microneedling products that enter the modern global market, it is of utmost importance to establish the safety profile and reasonable expectations of the microneedling practice and its products. In our review of current literature, the authors searched the keyword "microneedle" with the following terms: "safety", "side effect", "toxicology", "adverse effect", "adverse event", "infection", "dermatitis", "granuloma", "scarring", and "hyperpigmentation". Read More

Laryngorhinootologie 2019 Aug 26;98(8):555-561. Epub 2019 Jun 26.

Universitäts-Hals-Nasen-Ohrenklinik Ulm (Direktor Prof. Dr. T. Hoffmann), Sektion für Phoniatrie und Pädaudiologie (Leiterin Prof. Dr. S. Brosch) Frauensteige 12, 89075 Ulm.

Introduction: There are merely heterogenous therapy modalities for contact granulomas (CG) without evidenced efficacy. The intention of our study was to evaluate possible risk factors as well as to demonstrate therapeutic successful approaches.

Methods: Based on a retrospective analysis on 79 patients with CG we evaluated personal data for the first patient contact, for the first follow-up appointment (FA) averaged 3-4 months after the first contact, for the second follow-up appointment (SA) averaged 6-8 months after the first contact and for the last follow-up (LA) averaged 13 months after the first contact with collecting information concerning a possible gastrolaryngeal reflux disease as well as symptoms like harrumphing, hoarseness, hyperfunctional dysphonia as well as videostroboscopic signs. Read More

J Dtsch Dermatol Ges 2019 May;17(5):518-533

Department of Dermatology, Basel University Hospital, Basel, Switzerland.

Granulomatous dermatoses comprise a wide range of etiologically and clinically distinct skin diseases that share a common histology characterized by the accumulation of histiocytes include macrophages. While the pathogenesis of these disorders is not fully understood, the underlying mechanism is thought to involve a reaction pattern caused by an immunogenic stimulus. Antigen-presenting cells and the effect of various cytokines play a key role. Read More

J Feline Med Surg 2019 08 13;21(8):667-681. Epub 2019 May 13.

1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Edinburgh, UK.

Objectives: , a member of the complex, can infect cats and has proven zoonotic risks for owners. Infected cats typically present with a history of outdoor lifestyle and hunting behaviour, and cutaneous granulomas are most commonly observed. The aim of this study is to describe an outbreak of tuberculous disease commencing with six young cats, living exclusively indoors in five different households across England, being presented to separate veterinarians across the UK with a variety of clinical signs. Read More

Contact Dermatitis 2019 Aug 31;81(2):81-88. Epub 2019 May 31.

Department of Pediatrics, Sahlgrenska University Hospital, Göteborg, Sweden.

Background: According to studies on adults, patch testing with aluminium chloride hexahydrate 2% pet. is insufficient to detect aluminium allergy, and a 10% preparation is recommended. Other studies suggest that a 2% preparation is sufficient for testing children. Read More

Acta Clin Belg 2019 May 5:1-5. Epub 2019 May 5.

e Department of Gastroenterology , AZ Groeninge, President Kennedylaan , Kortrijk , Belgium.

Sarcoidosis is a multisystem disease of unclear etiology with a variable clinical profile characterized by the presence of non-caseating granuloma in involved organs. The diagnosis is often challenging and based on clinical, radiological and anatomopathological data. Sarcoidosis can be benign and self-limiting, but some cases may follow a chronic, progressive course and result in severe morbidity. Read More

Clin Ter 2019 Mar-Apr;170(2):e86-e92

Registered Nurse, Clinical Specialist in Wound Care, Clinical Specialist in Ostomy Care, Independent Tissue Viability Consultant, Rome, Italy.

Background: Peristomal granulomatosis is a chronic inflammatory disease of uncertain aetiology, and a high recurrence rate. It frequently occurs in patients with enterostomy and urostomy. The most frequent type affects the mucocutaneous junction, causing bleeding and painful nodular lesions, which complicate management of the ostomy pouching system. Read More

Int Ophthalmol 2019 Nov 9;39(11):2505-2515. Epub 2019 Mar 9.

Department of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Stavros Niarchos Avenue, 45110, Ioannina, Greece.

Purpose: To evaluate the clinical manifestations of intraocular inflammation associated with Bartonella infection and describe the assessment and management of patients with cat-scratch disease (CSD).

Methods: This is a retrospective review of the clinical records of patients diagnosed with Bartonella henselae and Bartonella quintana intraocular inflammation from 2011 to 2018 in the Department of Ocular Inflammations and Infections of the University Eye Clinic of Ioannina (Greece). An analysis of the current literature concerning Bartonella-related intraocular infections was also carried out. Read More

Dermatol Clin 2019 Apr 14;37(2):143-147. Epub 2019 Feb 14.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 Northwest 10th Avenue #1140, Miami, FL 33136, USA.

Various advancements in the diagnosis and management of nail diseases have transpired in recent years. To provide the best care for patients with nail complaints, it is essential that physicians be updated on new diagnostic and treatment modalities. The purpose of this article is to discuss new and oncoming diagnostic and management options for nail disorders, including nail psoriasis, retronychia, brittle nails, onychotillomania, trauma, trachyonychia, and pyogenic granulomas. Read More

Trop Doct 2019 Jul 25;49(3):227-229. Epub 2019 Feb 25.

4 Additional Professor and Head, Paediatric TB Clinic, Department of Paediatrics, Bai JerbaiWadia Hospital for Children, Mumbai, India.

We present here the case of a three-year-old girl with a maxillary myxoma misdiagnosed as tuberculosis (TB). She was referred to our TB clinic with fever for seven months and swelling of the left cheek and a positive Mantoux test. Her mother was also on treatment for TB lymphadenitis. Read More

Cardiol Res 2018 Dec 7;9(6):381-384. Epub 2018 Dec 7.

Department of Gynaecology Surgery, CHU Rangueil, Toulouse, France.

A ruptured breast implant is usually asymptomatic and accidentally discovered during an imaging test. However, implant ruptures can cause isolated silicone granulomas and cases of severe systemic disease. We report the first case of a 39-year-old female patient with augmentation breast implants and myopericarditis secondary to implant rupture. Read More

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

World Neurosurg 2019 Feb 17;122:360-363. Epub 2018 Nov 17.

Department of Neurosurgery, Saint-Luc Hospital, Université Catholique de Louvain, Brussels, Belgium. Electronic address:

Background: Cervical total disc arthroplasty (TDA), or cervical artificial disc replacement, is an alternative technique to anterior cervical discectomy and fusion for treatment of symptomatic degenerative cervical spine disease. The main goal of TDA is to maintain cervical motion and lower the risk of deterioration of adjacent levels. Granuloma formation on a cervical TDA is exceptional. Read More

Front Immunol 2018 10;9:2293. Epub 2018 Oct 10.

Experimental Pneumology, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research (DZL), Borstel, Germany.

Schistosomes control inflammation in their hosts highly effective mechanisms such as induction of Tregs, Bregs, and alternatively activated macrophages (AAMs). Notably, IPSE/alpha-1, the major secretory product from eggs, triggers basophils to release interleukin (IL)-4 and IL-13. Both cytokines are essential for AAM induction, suggesting an important role for IPSE/alpha-1 in inflammation control. Read More

Infect Drug Resist 2018 10;11:1685-1702. Epub 2018 Oct 10.

Pneumology Unit, Hospital General de México "Eduardo Liceaga", UNAM, Mexico City, Mexico.

Background: Resident alveolar macrophages, dendritic cells, and immigrating neutrophils (NEU) are the first cells to contact in the lung. These cells, and additional lymphoid cells in the developing granuloma, release a series of components that may concentrate in the serum and affect disease progression.

Purpose: The aim of this study was to investigate the effect of the serum from tuberculosis (TB) patients and their household contacts (HHC) on the nuclear morphology of NEU. Read More

Zhonghua Jie He He Hu Xi Za Zhi 2018 Oct;41(10):783-786

Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

To improve the clinical recognition of eosinophilic granulomatosis with polyangiitis(EGPA) in clinical manifestations, diagnosis and treatment. The clinical manifestations, pathological characteristic, imaging manifestations, diagnosis and the therapy of three patients with EGPA were presented. These 3 patients had asthma-like symptoms and extrapulmonary manifestations of systemic vasculitis. Read More

Pan Afr Med J 2018 29;30:71. Epub 2018 May 29.

Service des Maladies Infectieuses, Hôpital la Rabta, Tunis, Tunisie.

This study aimed to identify the epidemio-clinic, diagnostic, therapeutic and evolutionary features of genital tuberculosis (GT) among Tunisian women. We conducted a retrospective, descriptive study in the Department of Infectious Diseases at the La Rabta Hospital, Tunisia, over a period of 15 and a half years (January 2000 - June 2014). All patients hospitalized for genital TB were included in the study. Read More

Proc Natl Acad Sci U S A 2018 10 9;115(43):E10147-E10156. Epub 2018 Oct 9.

Université de Versailles Saint Quentin en Yvelines, INSERM UMR1173, 78000 Versailles, France;

is a peculiar rapid-growing (RGM) capable of surviving within eukaryotic cells thanks to an arsenal of virulence genes also found in slow-growing mycobacteria (SGM), such as A screen based on the intracellular survival in amoebae and macrophages (MΦ) of an transposon mutant library revealed the important role of MAB_0855, a yet uncharacterized Mycobacterial membrane protein Large (MmpL). Large-scale comparisons with SGM and RGM genomes uncovered MmpL12 proteins as putative orthologs of MAB_0855 and a locus-scale synteny between the and loci. A KO mutant of the gene, designated herein as , had impaired adhesion to MΦ and displayed a decreased intracellular viability. Read More

Infection 2018 Dec 4;46(6):885-889. Epub 2018 Oct 4.

Hospital Department of Specialized and Internal Medicine, Infectious Diseases Unit, University Hospital of Siena, Siena, Italy.

Acanthamoeba spp. is a free-living amoeba, frequently involved in keratitis by contact lens in immunocompetent hosts. Anecdotal reports associate Acanthamoeba spp. Read More

Case Rep Dermatol 2018 May-Aug;10(2):203-207. Epub 2018 Aug 23.

University of North Texas Health Science Center, Fort Worth, Texas, USA.

Granuloma gluteale infantum is a rare pediatric dermatological disorder of uncertain etiology. Suggested causes include fluorinated corticosteroids, , and irritant contact dermatitis. We present the case of a 3-year-old boy with recurrent episodes of granuloma gluteale infantum which resolved with treatment of his fecal overflow incontinence. Read More

Sultan Qaboos Univ Med J 2018 May 9;18(2):e215-e218. Epub 2018 Sep 9.

Department of Dermatology, Hospital Universitario Campus de la Salud, Granada, Spain.

In recent years, tattoos have become more commonplace. However, this can result in various inflammatory processes, the management of which can be challenging in daily clinical practice. Tattoo-related inflammatory reactions can comprise different patterns, including acute and immediate reactions, foreign body granulomas, sarcoid granulomas, isomorphic lesions, allergic contact dermatitis and photosensitivity. Read More

ORL J Otorhinolaryngol Relat Spec 2018;80(5-6):307-316. Epub 2018 Sep 11.

Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai,

Aims: To confirm the efficacy of conservative treatment for laryngeal contact granuloma and identify factors influencing treatment outcome.

Methods: In this prospective study, patients with laryngeal contact granuloma were divided into a group receiving conservative treatment and a group undergoing surgery. Efficacy was assessed by analyzing the complete response after a 48-week follow-up. Read More