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Cardiol Res 2018 Dec 7;9(6):381-384. Epub 2018 Dec 7.

Department of Gynaecology Surgery, CHU Rangueil, Toulouse, France.

A ruptured breast implant is usually asymptomatic and accidentally discovered during an imaging test. However, implant ruptures can cause isolated silicone granulomas and cases of severe systemic disease. We report the first case of a 39-year-old female patient with augmentation breast implants and myopericarditis secondary to implant rupture. Read More

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

World Neurosurg 2019 Feb 17;122:360-363. Epub 2018 Nov 17.

Department of Neurosurgery, Saint-Luc Hospital, Université Catholique de Louvain, Brussels, Belgium. Electronic address:

Background: Cervical total disc arthroplasty (TDA), or cervical artificial disc replacement, is an alternative technique to anterior cervical discectomy and fusion for treatment of symptomatic degenerative cervical spine disease. The main goal of TDA is to maintain cervical motion and lower the risk of deterioration of adjacent levels. Granuloma formation on a cervical TDA is exceptional. Read More

Front Immunol 2018 10;9:2293. Epub 2018 Oct 10.

Experimental Pneumology, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research (DZL), Borstel, Germany.

Schistosomes control inflammation in their hosts highly effective mechanisms such as induction of Tregs, Bregs, and alternatively activated macrophages (AAMs). Notably, IPSE/alpha-1, the major secretory product from eggs, triggers basophils to release interleukin (IL)-4 and IL-13. Both cytokines are essential for AAM induction, suggesting an important role for IPSE/alpha-1 in inflammation control. Read More

Infect Drug Resist 2018 10;11:1685-1702. Epub 2018 Oct 10.

Pneumology Unit, Hospital General de México "Eduardo Liceaga", UNAM, Mexico City, Mexico.

Background: Resident alveolar macrophages, dendritic cells, and immigrating neutrophils (NEU) are the first cells to contact in the lung. These cells, and additional lymphoid cells in the developing granuloma, release a series of components that may concentrate in the serum and affect disease progression.

Purpose: The aim of this study was to investigate the effect of the serum from tuberculosis (TB) patients and their household contacts (HHC) on the nuclear morphology of NEU. Read More

Zhonghua Jie He He Hu Xi Za Zhi 2018 Oct;41(10):783-786

Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

To improve the clinical recognition of eosinophilic granulomatosis with polyangiitis(EGPA) in clinical manifestations, diagnosis and treatment. The clinical manifestations, pathological characteristic, imaging manifestations, diagnosis and the therapy of three patients with EGPA were presented. These 3 patients had asthma-like symptoms and extrapulmonary manifestations of systemic vasculitis. Read More

Pan Afr Med J 2018 29;30:71. Epub 2018 May 29.

Service des Maladies Infectieuses, Hôpital la Rabta, Tunis, Tunisie.

This study aimed to identify the epidemio-clinic, diagnostic, therapeutic and evolutionary features of genital tuberculosis (GT) among Tunisian women. We conducted a retrospective, descriptive study in the Department of Infectious Diseases at the La Rabta Hospital, Tunisia, over a period of 15 and a half years (January 2000 - June 2014). All patients hospitalized for genital TB were included in the study. Read More

Proc Natl Acad Sci U S A 2018 10 9;115(43):E10147-E10156. Epub 2018 Oct 9.

Université de Versailles Saint Quentin en Yvelines, INSERM UMR1173, 78000 Versailles, France;

is a peculiar rapid-growing (RGM) capable of surviving within eukaryotic cells thanks to an arsenal of virulence genes also found in slow-growing mycobacteria (SGM), such as A screen based on the intracellular survival in amoebae and macrophages (MΦ) of an transposon mutant library revealed the important role of MAB_0855, a yet uncharacterized Mycobacterial membrane protein Large (MmpL). Large-scale comparisons with SGM and RGM genomes uncovered MmpL12 proteins as putative orthologs of MAB_0855 and a locus-scale synteny between the and loci. A KO mutant of the gene, designated herein as , had impaired adhesion to MΦ and displayed a decreased intracellular viability. Read More

Infection 2018 Dec 4;46(6):885-889. Epub 2018 Oct 4.

Hospital Department of Specialized and Internal Medicine, Infectious Diseases Unit, University Hospital of Siena, Siena, Italy.

Acanthamoeba spp. is a free-living amoeba, frequently involved in keratitis by contact lens in immunocompetent hosts. Anecdotal reports associate Acanthamoeba spp. Read More

Case Rep Dermatol 2018 May-Aug;10(2):203-207. Epub 2018 Aug 23.

University of North Texas Health Science Center, Fort Worth, Texas, USA.

Granuloma gluteale infantum is a rare pediatric dermatological disorder of uncertain etiology. Suggested causes include fluorinated corticosteroids, , and irritant contact dermatitis. We present the case of a 3-year-old boy with recurrent episodes of granuloma gluteale infantum which resolved with treatment of his fecal overflow incontinence. Read More

Sultan Qaboos Univ Med J 2018 May 9;18(2):e215-e218. Epub 2018 Sep 9.

Department of Dermatology, Hospital Universitario Campus de la Salud, Granada, Spain.

In recent years, tattoos have become more commonplace. However, this can result in various inflammatory processes, the management of which can be challenging in daily clinical practice. Tattoo-related inflammatory reactions can comprise different patterns, including acute and immediate reactions, foreign body granulomas, sarcoid granulomas, isomorphic lesions, allergic contact dermatitis and photosensitivity. Read More

ORL J Otorhinolaryngol Relat Spec 2018 11;80(5-6):307-316. Epub 2018 Sep 11.

Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai,

Aims: To confirm the efficacy of conservative treatment for laryngeal contact granuloma and identify factors influencing treatment outcome.

Methods: In this prospective study, patients with laryngeal contact granuloma were divided into a group receiving conservative treatment and a group undergoing surgery. Efficacy was assessed by analyzing the complete response after a 48-week follow-up. Read More

Clin Microbiol Rev 2018 10 29;31(4). Epub 2018 Aug 29.

Biomedical Laboratory Diagnostics, Michigan State University, East Lansing, Michigan, USA

The pathogenic entomophthoralean fungi cause infection in insects and mammalian hosts. and species can be found in soil and insect, reptile, and amphibian droppings in tropical and subtropical areas. The life cycles of these fungi occur in these environments where infecting sticky conidia are developed. Read More

Curr Opin Ophthalmol 2018 Nov;29(6):582-587

Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose Of Review: To review the systemic and ocular complications of Bartonella spp. infections specifically cat scratch disease, encompassing epidemiology, laboratory diagnostics, ophthalmic imagining, and treatment.

Recent Findings: Recent studies have shown that ocular manifestations occur in approximately 4. Read More

Eye Contact Lens 2018 Nov;44 Suppl 2:S333-S337

Department of Ophthalmology (C.-J.H., C.-J.L., W.-H.T., Y.-C.H., I.-J.W., F.-R.H., W.-L.C.), National Taiwan University Hospital, Taipei, Taiwan; and Center of Corneal Tissue Engineering and Stem Cell Biology (F.-R.H., W.-L.C.), National Taiwan University Hospital.

Purpose: To evaluate the complications and the treatment results of SmartPlug-related complications.

Methods: Retrospective review of all patients from a single medical hospital who received SmartPlug (Medennium, Inc., Irvine, CA) insertions from October 2007 to February 2014. Read More

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

J Small Anim Pract 2018 Jun 5. Epub 2018 Jun 5.

Centre Hospitalier Vétérinaire Atlantia, 44200 Nantes, France.

Vocal cord granulomas are rarely observed in brachycephalic breeds but often reported in humans as contact granulomas. Six French bulldogs were included in this retrospective descriptive study. Endoscopic laryngeal examinations were performed on all dogs under general anaesthesia. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Aug;31(15):1217-1220

Laryngeal contact granuloma, also known as vocal cord granuloma, is the non-neoplastic inflammatory granulation tissue occurring in the vocal cord around. The cause is unclear, morbidity and cure rate is low, the recurrence rate is high, leading to a poor clinical treatment. But some symptoms of the sound disorder, pharyngeal foreign body sensation seriously affect the quality of life of patients, increase the psychological burden of patients. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jul;31(13):1006-1009

Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, 630041, China.

Anti-reflux medications or botulinum toxin A injections are the main current therapies for the definite vocal process granuloma. This studies is focusing on comparing the effects of proton pump inhibitors plus prokinetic agents with botulinum toxin A injections on vocal process granuloma. Adult patients in our outpatient department (from December 2014 to June 2016) complaining of trachyphonia and/or abnormal pharyngeal sensations who were found to have contact granulomas (38 cases) were included. Read More

Acta Dermatovenerol Croat 2018 Apr;26(1):75-76

Antigona Begolli Gerqari, MD, Dermatovenerology Clinic, University Clinical Center 10000 Pristina , Republic of Kosovo;

Tattooing is a procedure where ink is applied to an area of the skin, mostly intraepidermally (1). This procedure is carried out mainly for aesthetic purposes. Lately, it has been used as a corrective medical procedure following amputation of mammilla. Read More

Theranostics 2018 23;8(9):2407-2423. Epub 2018 Mar 23.

Institute of Immunology, University of Münster, 48149 Münster, Germany.

Recruitment of leukocytes from the blood to sites of inflammation poses a promising target for new diagnostic and therapeutic approaches. We aimed to develop a novel method to non-invasively analyze molecular mechanisms of leukocyte migration in pre-clinical models of inflammation . We used the ER-HoxB8 system to transiently immortalize murine myeloid precursors from and CD18- as well as MRP14-deficient mice. Read More

J Neurosurg 2018 Apr 1:1-6. Epub 2018 Apr 1.

OBJECTIVETrigeminal neuralgia is a debilitating pain disorder most often caused by arterial compression of the trigeminal nerve, although there are other etiologies. Microvascular decompression (MVD) remains the most definitive treatment for this disorder, with cure rates reported between 60% and 80%. Traditional MVD techniques involve a retrosigmoid craniotomy with placement of an inert foreign material, such as Teflon, between the nerve and compressive vessel. Read More

Laryngorhinootologie 2018 04 10;97(4):238-245. Epub 2018 Apr 10.

Technische Universität München Hals-Nasen-Ohrenklinik.

The prevalence of laryngopharyngeal reflux (LPR) is around 31 % in the general population. Patients with a dysphonia or other laryngeal diseases are accompanied up to 50 % by an LPR. Typical reflux associated diseases of the larynx are a chronical laryngitis and a contact granuloma. Read More

Contact Dermatitis 2018 Jul 1;79(1):41-42. Epub 2018 Mar 1.

Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.

Patient Relat Outcome Meas 2018 4;9:17-34. Epub 2018 Jan 4.

Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Objective: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are multisystem diseases of the small blood vessels. Patients experience irreversible damage and psychological effects from AAV and its treatment. An international collaboration was created to investigate the impact of AAV on health-related quality of life (HRQoL), and develop a disease-specific patient-reported outcome measure to assess outcomes of importance to patients. Read More

Contact Dermatitis 2018 Jan;78(1):94-95

Department of Dermatology, Kochi Medical School, Kochi University, Kochi 783-8505, Japan.

Vet Pathol 2018 03 19;55(2):303-309. Epub 2017 Dec 19.

5 Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Ames, IA, USA.

Wild banded mongooses ( Mungos mungo) in northeastern Botswana and northwest Zimbabwe are infected with a novel Mycobacterium tuberculosis complex (MTC) pathogen, Mycobacterium mungi. We evaluated gross and histologic lesions in 62 infected mongooses (1999-2017). Many tissues contained multifocal irregular, lymphohistiocytic to granulomatous infiltrates and/or multifocal or coalescing noncaseating to caseating granulomas with variable numbers of intralesional acid-fast bacilli. Read More

Actas Dermosifiliogr 2018 Mar 6;109(2):162-172. Epub 2017 Dec 6.

Unidad de Alergia Cutánea, Servicio de Dermatología, Hospital General Universitario de Alicante - ISABIAL, Alicante, España.

Introduction: Tattooing has become a popular practice in western countries, particularly among younger populations. Tattoos, however, can cause complications, such as infections, allergic or foreign-body reactions, and even systemic inflammatory responses.

Patients And Methods: We conducted a retrospective study of all patients seen for tattoo-related complications at our skin allergy unit between January 2002 and December 2016. Read More

J Crohns Colitis 2018 Jan;12(2):197-203

Hospital Universitari Germans Trias i Pujol, Badalona, and CIBEREHD, Madrid, Spain.

Background: Genital granulomatosis [GG] is a metastatic form of Crohn's disease [CD], characterised by granulomatous inflammation of the genital skin without contact with the gastrointestinal tract. Little is known about GG, as most publications are case reports or small series, and only sporadic in male cases.

Methods And Aims: Cases of GG were retrospectively collected through the Collaborative Network For Exceptionally Rare case reports project of the European Crohn's and Colitis Organisation. Read More

J Thorac Dis 2017 Aug;9(8):E709-E713

Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

We report a first case of a patient experiencing reactivation of pulmonary tuberculosis (TB) during treatment of oral tyrosine kinase inhibitor (TKI) with non-small cell lung cancer (NSCLC). A 44-year-old male patient visited the hospital with cough. He had been treated with erlotinib (oral TKI) for 8 months after being diagnosed as NSCLC with sensitive epidermal growth factor receptor mutation in our clinic. Read More

Int J Clin Pediatr Dent 2017 Apr-Jun;10(2):188-192. Epub 2017 Jun 1.

Professor and Principal, Department of Pedodontics and Preventive Dentistry, Eklavya Dental College, Kothputli, Rajasthan, India.

Soft tissue laser, such as diode and Nd:YAG lasers were initially used in soft tissue lesions because of its increased success rate. It was because of the fact that these lasers were well-absorbed by chromophores, such as hemoglobin and melanin which are found abundant in the oral mucosa. The introduction of erbium family in 1990 comprising the Er:YAG and Er,Cr:YSGG lasers made the hard tissue laser a boon for dentistry. Read More

Asia Pac J Ophthalmol (Phila) 2017 Sep-Oct;6(5):435-443. Epub 2017 Aug 22.

Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

Purpose: Adult xanthogranulomatous disease of the orbit and ocular adnexa is a rare disease that can cause serious morbidity and mortality. Ophthalmologists are commonly the first clinicians to come in contact with affected patients and an understanding of the clinical features is essential.

Design: We present a retrospective case series of patients seen in the oculoplastic unit of a large tertiary referral hospital over a 20-year period. Read More

J Voice 2018 May 1;32(3):363-366. Epub 2017 Aug 1.

Drexel University College Of Medicine, Department of Otolaryngology-Head & Neck Surgery, Philadelphia, Pennsylvania.

Objective: Contact granulomas are benign, exophytic inflammatory lesions of the larynx that typically arise on or near the vocal process of the arytenoid cartilage. The most common management options include voice therapy and antireflux pharmacotherapy, intralesional steroid injections, botulinum toxin injections, and surgical excision. In-office Botox injection into the lateral cricoarytenoid (LCA) muscle can be effective even for recurrent granulomas. Read More

Med Mycol Case Rep 2017 Dec 6;18:5-7. Epub 2017 Jul 6.

Public Health Microbiology Forensic and Scientific Services, Health Support Queensland, Australia.

Severe dermatophyte infection is rare in immunocompetent adults. Recently cases have been described in travelers returning from South East Asia (Luchsinger et al., 2015) [1]. Read More

Medicine (Baltimore) 2017 Jul;96(29):e7562

aDivision of Infectious Diseases and Hospital Epidemiology bChildren's Research Center, University Children's Hospital Zurich cDivision of Clinical Pathology, University Hospital Zurich dInstitute of Medical Microbiology eSwiss National Center for Mycobacteria, University of Zurich fDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Rationale: Congenital tuberculosis (TB) is described as a rare, but severe disease. In contrast to the cases with severe symptoms reported so far, we describe a child with asymptomatic congenital TB.

Patient Concerns: An 8-week-old girl was investigated because of newly diagnosed TB in her mother, which complained about cough since 21 weeks gestation. Read More

Insights Imaging 2017 Aug 14;8(4):439-446. Epub 2017 Jul 14.

Department of Radiology, Santa Casa de Misericórdia de São Paulo, Rua Maestro Chiaffarelli, 409, Jardim Paulista, São Paulo, SP, 01432-030, Brazil.

Complications resulting from the placement of silicone breast implants are becoming more frequent in our clinical practice. This is due to the increase in breast aesthetic surgeries at the beginning of the century, where breast augmentation using silicone implants was the main intervention performed. Generally, studies that discuss the complications of breast implants are restricted to reports of intra- or extra-capsular ruptures, contractures and haematomas. Read More

Otolaryngol Head Neck Surg 2017 12 11;157(6):1013-1016. Epub 2017 Jul 11.

4 Department of Otorhinolaryngology Head and Neck Surgery, Binzhou Central Hospital, Binzhou, China.

Objective To explore high-resolution computed tomography (HRCT) characteristics of arytenoid cartilage in patients with laryngeal contact granuloma (LCG). Setting Tertiary hospitals. Study Design Individual case-control study. Read More

Am J Otolaryngol 2017 Sep - Oct;38(5):593-597. Epub 2017 Jun 21.

Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.

Objectives: Vocal process granulomas have a high tendency for persistence despite many treatment alternatives. Anti-reflux medications or botulinum toxin A injections are the main current therapies. There are no studies that compare the effects on vocal process granuloma of proton pump inhibitors plus prokinetic agents with botulinum toxin A injections. Read More

J Ophthalmic Inflamm Infect 2017 Dec 23;7(1):13. Epub 2017 May 23.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, 5019, Monastir, Tunisia.

Background: The purpose of this single case report was to report the use of anterior segment optical coherence tomography for the diagnosis and management of a retained vegetal intraocular foreign body.

Results: A 23-year-old otherwise healthy male presented with a progressive vision loss in the right eye (RE). He reported a mild ocular trauma with a tree leaf 1 year ago followed by recurrent episodes of redness and pain in the RE that partially resolved after a self-medication with topical steroids. Read More

G Ital Dermatol Venereol 2018 Oct 16;153(5):644-648. Epub 2017 May 16.

Department of Dermatology, Federico II University of Naples, Naples, Italy.

Background: Decorative tattooing as a body art form underwent an exponential increase during the last two decades, particularly among teenagers and young adults. Consequently, the number of reported adverse reactions after tattooing has increased. The most frequent reported skin reactions to tattoo include infectious (bacterial, viral, fungal) or inflammatory (allergic contact dermatitis and granulomatous reaction) diseases. Read More

Multidiscip Respir Med 2017 8;12:10. Epub 2017 May 8.

Department of Pathology, University of Texas Medical Branch (UTMB), 301 University Blvd #1, Galveston, TX 77555 USA.

Background: Hypersensitivity pneumonitis (HP) is a common diffuse parenchymal lung disease in Egypt which can be difficult to recognize due to the dynamic symptoms & associated environmental factors.

Methods: Forty-three Egyptian patients were enrolled in this study, presenting with dyspnea and cough, predominant ground-glass opacity (GGO) in high-resolution computed tomography (HRCT) where lung biopsy was needed to establish the diagnosis.

Results: The age range was 15 to 60 years. Read More

Sci Rep 2017 Apr 24;7:46666. Epub 2017 Apr 24.

Department of Infectious Disease Immunology, Statens Serum Institut, DK-2300, Copenhagen, Denmark.

Although Mycobacterium tuberculosis (M.tb) DK9897 is an attenuated strain, it was isolated from a patient with extrapulmonary tuberculosis and vaccination with a subunit vaccine (H56) induced poor protection against it. Both attenuation and lack of protection are because M. Read More

BMC Surg 2017 Apr 17;17(1):40. Epub 2017 Apr 17.

Department of Pathology, Kirikkale University Medical Faculty, Tahsin Duru Cad. No:14, Yenisehir, Yahsihan, 71450, Kirikkale, Turkey.

Background: An incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. Read More

Curr Probl Dermatol 2017 13;52:42-57. Epub 2017 Mar 13.

The 'Tattoo Clinic', Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.

Diagnosis of tattoo complications is a multi-facetted field since many clinical entities and disease mechanisms are represented. Infections, allergies, and pigment foreign body reactions with granuloma are the major groups. The clinician needs a structured approach to diagnosis and an armamentarium of standard tests. Read More

Curr Probl Dermatol 2017 10;52:58-73. Epub 2017 Mar 10.

The 'Tattoo Clinic', Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.

Tattoo complications represent a broad spectrum of clinical entities and disease mechanisms. Infections are known, but chronic inflammatory reactions have hitherto been inconsistently reported and given many interpretations and terms. A clinical classification system of distinct patterns with emphasis on inflammatory tattoo reactions is introduced. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Feb;31(3):230-232

Ophthalmology 2016 12 18;123(12):2595-2602. Epub 2016 Oct 18.

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Electronic address:

Purpose: Large relaxing retinectomies have become increasingly used in the repair of retinal detachment related to proliferative vitreoretinopathy (PVR). Retinectomies expose the retinal pigment epithelium (RPE) to the vitreous cavity; the direct effects of silicone oil on the RPE are only beginning to be understood.

Design: Retrospective case series. Read More

Tuberculosis (Edinb) 2016 12 28;101S:S2-S8. Epub 2016 Sep 28.

Department of Pathology and Laboratory Medicine, University of Texas, Houston Medical School, MSB 2.136, 6431 Fannin, Houston, TX, 77030, USA.

Mycobacterium tuberculosis (MTB) has long been known to persist in grossly normal tissues even in people with active lesions and granulomas in other parts of the body. We recently reported that post-primary TB begins as an asymptomatic infection that slowly progresses, accumulating materials for a massive necrotizing reaction that results in cavitation. This paper explores the possible roles of trehalose 6,6' dimycolate (TDM) or cord factor in the ability of MTB to persist in such lesions without producing inflammation. Read More

Dermatol Pract Concept 2016 Jul 31;6(3):17-22. Epub 2016 Jul 31.

Dermatology Department Cairo University, Cairo, Egypt.

Background: Diagnosing cutaneous sarcoidosis and necrobiotic granulomas is challenging.

Objective: Assessing the value of dermoscopy in differentiating cutaneous sarcoidosis from necrobiotic granulomas and evaluating whether their dermoscopic features will be altered after treatment.

Methods: Nineteen cutaneous sarcoidosis and 11 necrobiotic granuloma patients (2 necrobiosis lipoidica, 4 granuloma annulare and 5 rheumatoid nodule) were included in this study. Read More