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Adv Biomed Res 2020 23;9:75. Epub 2020 Dec 23.

Department of Pediatrics, Pediatric Neurology Division, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Extrapulmonary tuberculosis (TB) is a well-recognized cause of pyrexia of unknown origin. However, clinical presentation of TB in children with isolated hematological abnormalities is extremely rare. Anemia, usually normocytic, normochromic, leukopenia, leukocytosis, thrombocytopenia, thrombocytosis, and monocytosis are more common complications of TB rather than pancytopenia. Read More

Head Neck Pathol 2021 Apr 26. Epub 2021 Apr 26.

Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, 02115, USA.

Background: Irritant contact stomatitis (ICS) and contact hypersensitivity stomatitis (CHS) are often caused by alcohol, flavoring agents and additives in dentifrices and foods, and contactants with high or low pH. A well-recognized contactant for ICS is Listerine™ mouthwash, while that for CHS is cinnamic aldehyde. However, many other flavoring agents and even smokeless tobacco are contactants that cause mucosal lesions that are entirely reversible. Read More

Joint Bone Spine 2021 Apr 7;88(4):105183. Epub 2021 Apr 7.

Rheumatology department, GHUPSSD, AP-HP, Bobigny, France; Inserm UMR 1125, Université Sorbonne Paris Nord, 93000 Bobigny, France. Electronic address:

Background: "Sarcoidosis-like" paradoxical reactions to Antitumor necrosis factor α (anti-TNFα) treatment have been reported. The clinical presentations are varied, most of the time, with a relatively typical picture of mediastinopulmonary involvement. More rarely, isolated granulomatous locations from various organs are described, leading to difficulties in diagnosis. Read More

Contact Dermatitis 2021 Apr 1. Epub 2021 Apr 1.

National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Aluminium contact allergy is mainly seen as granulomas following immunization with aluminium-adsorbed vaccines and contact allergy following epicutaneous exposure may be overlooked. To investigate the prevalence of aluminium allergy confirmed by patch testing, with no association with vaccination granulomas, and explore whether epicutaneous exposure to aluminium can contribute to allergic contact dermatitis. Two authors independently searched PubMed and MEDLINE (OVID) for case studies on contact allergy to aluminium proven by patch testing. Read More

Tech Innov Patient Support Radiat Oncol 2021 Jun 18;18:8-11. Epub 2021 Mar 18.

Instituto Brasileiro de Controle do Câncer - IBCC, Brazil.

Breast reconstructive surgery with silicone implants is routinely one of the techniques performed immediately after a mastectomy and before adjuvant radiotherapy. Implant shell degradation may result in gel bleeding that can trigger capsular disease. The silicone corpuscle in contact with the implant fibrous capsule can promote an inflammatory reaction, identified as silicone-induced granuloma which is, related to clinical complaints referred to as breast implant illness. Read More

World J Clin Cases 2021 Mar;9(8):1989-1995

Department of Otorhinolaryngology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China.

Background: Laryngeal contact granuloma (LCG) is difficult to treat and frequently associated with high persistence and recurrence, despite the availability of both surgical and pharmacological treatment options. An appropriate strategy is therefore needed to help patients with multiple recurrences of LCG to potentially avoid unnecess-ary surgery.

Case Summary: We describe the case of a 34-year-old male patient with recurrent LCG in which a good response was achieved through successful management of laryngophar-yngeal reflux disease using a combination pharmacotherapeutic regimen consisting of anti-reflux therapy, pepsin secretion inhibition, bile acid neutralization, and lifestyle modifications. Read More

Ned Tijdschr Geneeskd 2021 03 11;165. Epub 2021 Mar 11.

Röpcke-Zweers ziekenhuis (Saxenburgh Groep), afd. Interne Geneeskunde, Hardenberg.

Background: The term Wolf's isotopic response has been used to describe the occurrence of a new skin disorder at the site of another, unrelated and already healed skin disease.

Case Description: A 74-year-old man with type 2 diabetes mellitus and prostate carcinoma with osseous and lymphatic metastases developed a herpes zoster infection of the left shoulder after palliative radiation therapy of this area. After several months multiple lenticular erythematous papules and some plaques were seen at the previously infected location. Read More

Zhonghua Bing Li Xue Za Zhi 2021 Mar;50(3):222-228

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To analyze the clinicopathological and immunohistochemical characteristics of the hypersensitivity pneumonia (HP) cases that were diagnosed by excisional lung biopsy, to improve the diagnosis accuracy of HP. The data of 47 HP cases diagnosed by excisional lung biopsy during the last 20 years were collected in Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, from January 2000 to June 2020. The clinicopathological features and the immunohistochemical profiles of CD3, CD4, CD8 and CD20 were analyzed using light microscopy and immunohistochemical stains. Read More

GMS Ophthalmol Cases 2021 28;11:Doc02. Epub 2021 Jan 28.

Federal University of Rio de Janeiro, Campus Macaé (UFRJ), Rio de Janeiro, Brazil.

Parinaud's oculoglandular syndrome (POS) is a clinical condition characterized by granulomatous conjunctivitis associated with homolateral neck pain and anterior preauricular lymphadenopathy. Several reports of this condition occurred and some bacterial etiological agents were identified. However, fungal infections have also been associated, especially sporotrichosis. Read More

Optom Vis Sci 2021 Mar;98(3):217-221

Division of Dermatopathology, Columbia University Medical Center, New York, New York.

Significance: Hemolacria (bloody tears) is a rare clinical presentation with varied underlying etiologies. Thorough clinical evaluation is essential to diagnosis and management.

Purpose: This study aimed to report unilateral hemolacria in a known contact lens wearer with an occult, palpebral, conjunctival pyogenic granuloma and review the literature. Read More

Ann Chir Plast Esthet 2021 Feb 4. Epub 2021 Feb 4.

HCL, Plastic surgery departement, Hôpital de la croix rousse, 103, grande rue de la croix rousse, 69004 Lyon, France. Electronic address:

Introduction: The management of 10 cases of penile inflammatory granulomas following a subcutaneous injection of non-absorbable substance for the purpose of penile augmentation is presented. We subsequently used the bilateral scrotal flaps to cover the post-excision skin defect. A simple decision aid chart outlining the management of penile foreign body injections is proposed. Read More

Cutis 2020 Nov;106(5):265-267

Department of Dermatology, John P. and Kathrine G. McGovern Medical School at the University of Texas Health Science Center at Houston, USA.

Mercury poisoning is a rare event that can present with a variety of nonspecific systemic symptoms, making it difficult to diagnose. Dermatologic manifestations of mercury exposure may be variable and include pink disease (acrodynia), mercury exanthem, contact dermatitis, and cutaneous granulomas. We present the case of an 18-year-old woman with a palmoplantar eruption associated with tachycardia, hyperhidrosis, myalgia, paresthesia, and muscle fasciculations. Read More

Eur Arch Otorhinolaryngol 2021 May 13;278(5):1499-1504. Epub 2021 Jan 13.

Department of Otolaryngology Head and Neck Surgery, Sixth Medical Center of PLA General Hospital; College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.

Objective: To evaluate the short-term efficacy of transcutaneous glucocorticoid injection for laryngeal contact granuloma in females.

Methods: A total of 14 female patients with laryngeal contact granuloma treated in our outpatient department from November 2017 to January 2020 were included in the study. Inspiratory-phase laryngoscopy images were collected before treatment and 1 month after each injection, and the lesion size was measured and evaluated with ImageJ software. Read More

Vet Med Sci 2020 Dec 18. Epub 2020 Dec 18.

Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Japan.

Bacterial placentitis in horses commonly results in abortion, premature birth or compromised neonatal foal health. Although mycobacterial infections are generally uncommon in horses, 10 equine abortion cases caused by Mycobacterium avium subsp. hominissuis (MAH) infections occurred between 2018 and 2019 in Japan. Read More

Eur J Obstet Gynecol Reprod Biol 2020 Dec 3;255:247-252. Epub 2020 Oct 3.

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

To evaluate Gene Xpert for diagnosis of Female Genital Tuberculosis (FGTB) as compared to conventional methods.

Study Design: It was a prospective study conducted over 167 cases of infertile female genital tuberculosis (FGTB) diagnosed on composite reference standard (CRS) (smear for AFB, histopathological evidence of epithelioid granuloma or definite or possible findings of tuberculosis on laparoscopy). All women underwent endometrial biopsy for AFB microscopy, culture, gene Xpert, PCR and histopathology) and laparoscopy and hysteroscopy for diagnosis and prognostication of disease. Read More

J Cutan Pathol 2021 Mar 2;48(3):429-433. Epub 2020 Dec 2.

Western Pathology, Inc, San Luis Obispo, California, USA.

Diatoms are photosynthetic algae with a siliceous exoskeleton. Diatoms are utilized by a wide array of industries for applications such as filtration and pest control. Unsubstantiated claims have also propelled their societal reach to trendy oral and topical uses. Read More

Am J Otolaryngol 2021 Jan - Feb;42(1):102766. Epub 2020 Oct 22.

Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China.

Objective: To compare the therapeutic effect of PPI and combined treatment in the treatment of patients with recurrent laryngeal contact granuloma.

Methods: The clinical data of 299 patients with recurrent laryngeal contact granuloma treated with PPI or combined treatment (PPI with glucocorticoid injection into granuloma by the thyroglossal approach) from February 2013 to June 2019 were analyzed retrospectively. Patients were divided into two subgroups: PPI and combined treatment. Read More

Vet Med Int 2020 25;2020:8898874. Epub 2020 Sep 25.

School of Veterinary Medicine College of Agricultural Science, Bule Hora University, P.O. Box 144, Bule Hora, Ethiopia.

Small ruminant is an important and integral part of livestock in Ethiopia. Especially, goats are attractive to people of Ethiopia because of the ability to resist challenges, easily adapt to different ecological regions, and need small land to rearing and small initial capital in which poor people can engaged in the production system. In spite of the presence of large number of goat population in Ethiopia, it fails to utilize expected productivity due to many factors. Read More

J Voice 2020 Sep 9. Epub 2020 Sep 9.

Dubai Hospital, DHA, UAE; ENT Department, Alexandria University, Egypt.

Objective: To identify the possible risk factors related to etiology of the minimal associated pathological lesions (MAPLs) of the vocal folds and their impacts on the recurrence of lesion.

Methods: This analytical cross-sectional study included 200 subjects presented with dysphonia to the Phoniatrics/Voice Clinics in two hospitals in Gulf region (KSA and UAE). Same number of matched voluntaires from the same hospitals (hospital staffs, employees and their relatives) and relatives of subjects with typical voice quality were included as well. Read More

J Voice 2020 Sep 8. Epub 2020 Sep 8.

Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China.

Objective: To explore the factors affecting the therapeutic efficacy of laryngeal contact granuloma.

Methods: The clinical data of 534 patients with laryngeal contact granuloma treated in our hospital from April 2014 to December 2019 were studied. The multivariable logistic regression was performed to find the risk factors influencing the treatment efficacy. Read More

Am J Ophthalmol Case Rep 2020 Sep 6;19:100865. Epub 2020 Aug 6.

Department of Ophthalmology, Complexo Hospitalar Padre Bento de Guarulhos, 1819 Emilio Ribas Avenue, Gopouva, 07051-000, Guarulhos, São Paulo, Brazil.

Purpose: To present 10 cases of Parinaud oculoglandular syndrome caused by sporotrichosis.

Observations: We report 10 cases of Parinaud oculoglandular syndrome after contact with domestic cats diagnosed with sporotrichosis. They all showed ocular hyperemia associated with unilateral tarsal conjunctival granulomas. Read More

Vet Pathol 2020 11 31;57(6):825-837. Epub 2020 Aug 31.

1355University of Georgia, Athens, GA, USA.

Ophidiomycosis (snake fungal disease) is caused by the fungus . As ophidiomycosis is difficult to study in free-ranging snakes, a reliable experimental model is needed to investigate transmission, pathogenesis, morbidity, and mortality, and the effects of brumation and temperature on disease development. Our objective was to develop such a model via subcutaneous injection of conidia in red cornsnakes (). Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Apr;34(4):360-363

Department of Otolaryngology Head and Neck Surgery，the Sixth Medical Center of the PLA General Hospital.

To investigate the clinical characteristics, diagnosis and treatment of female laryngeal contact granuloma. The clinical data of 46 female patients with laryngeal contact granuloma diagnosed and treated by our clinical team from March 2011 to October 2018 were retrospectively analyzed. The age of the 46 patients ranged from 5 to 58 years old, with an average age of 36. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Mar;34(3):263-265

Department of Otorhinolaryngology Head and Neck Surgery，the Sixth Medical Center of PLA General Hospital.

To investigate the relationship between laryngopharyngeal reflux and arytenoid cartilage calcification in male idiopathic laryngeal contact granuloma. The clinical data of 92 male patients with idiopathic laryngeal contact granuloma who had the thin laryngeal CT scan images and laryngeal reflux symptom index（RSI） scale data before treatment were analyzed retrospectively. The effect of laryngopharyngeal reflux on the calcification of arytenoid cartilage in laryngeal contact granuloma patients was analyzed by Chi-square statistics with SPSS 16. Read More

Presse Med 2020 Dec 5;49(4):104047. Epub 2020 Aug 5.

Dermatology, AZ Sint-Jan Brugge-Oostende AV, Meiboomstraat 15, 8370 Blankenberge, Belgium. Electronic address:

Allergic reactions in tattoos and permanent make-up are rare but they could be problematic. The clinical presentation and the histopathology are diverse and often confusing. Symptomatic treatment is frequently unsuccessful and invasive techniques can be required. Read More

Wiad Lek 2020 ;73(4):814-817

Department of Clinical Phonoaudiology and Speech Therapy, Medical University Of Bialystok, Bialystok, Poland.

Voice is a work tool for many professional groups. Currently, cases of dysphonia of multiple origin consist a growing issue. Voice disorders may result from disturbed voice production process, congenital defects, post-traumatic conditions, chronic diseases or hormonal disorders. Read More

Braz J Microbiol 2020 Dec 22;51(4):2169-2173. Epub 2020 Jul 22.

Setor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Rio Grande do Sul, 91540-000, Porto Alegre, Brazil.

Tuberculosis is a common zooanthroponosis in humans with a high incidence in Brazil, but it may also affect non-human primates (NHPs), of which Old World primates are most commonly involved. Nonetheless, its occurrence in New World primates is unknown, and therefore, this study aimed to describe the infection by Mycobacterium tuberculosis variant tuberculosis in two captive black capuchin monkeys (Sapajus nigritus) in Southern Brazil. The primates were housed in the same enclosure, wherein close contact with humans frequently occurred, and presented apathy, anorexia, and death in a clinical course of 15 days to 2 months. Read More

J Clin Tuberc Other Mycobact Dis 2020 Aug 22;20:100162. Epub 2020 Apr 22.

Pulmonology, Sri Ramachandra University Medical College, Porur, Chennai, Tamil Nadu 600116, India.

Tuberculosis of the tonsils is a rare type of extra pulmonary tuberculosis. The secondary form is more common than the primary, usually caused by the contact with the infected sputum or saliva from a sputum smear positive case of tuberculosis. We report a primary form of tonsillar tuberculosis in 10-year-old boy, with no remote history suggestive of documented pulmonary tuberculosis. Read More

Dermatol Ther 2020 11 26;33(6):e13966. Epub 2020 Jul 26.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

A 65-year-old women presented with sharply demarcated macules and small nodules on her face and neck for 2.5 years. They first appeared on her left face and gradually spread to her whole face and neck. Read More

Gen Dent 2020 Jul-Aug;68(4):28-31

The conventional method of managing intraoral soft tissue overgrowth involves surgical excision using a scalpel under local anesthesia. These procedures are often associated with excessive bleeding that leads to complications. Now, minimally invasive methods such as laser excision are available for the management of intraoral soft tissue lesions. Read More