Immunol Lett 2021 07 2;235:15-21. Epub 2021 May 2.
Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, PR China. Electronic address:
Repeated exposure to fungi-contaminated dust can lead to multiple adverse effects on the lung, such as hypersensitivity pneumonitis, granuloma even irreversible fibrosis. 1,3-β-glucan, a major cell wall component of fungi, is considered as its exposure biomarker. Existing studies showed that a series of Th responses were involved in 1,3-β-glucan induced hypersensitivity pneumonitis, in which macrophages, Treg, and IL-10 producing B cells were reported to participate. Read More