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    4533 results match your criteria Contact Dermatitis Irritant

    1 OF 91

    Hairdressers' skin exposure to hair dyes during different hair dyeing tasks.
    Contact Dermatitis 2017 Aug 9. Epub 2017 Aug 9.
    Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.
    Background: The high risk of occupational skin disease among hairdressers, caused by skin exposure to irritants and sensitizers, such as hair dye substances, is of great concern.

    Objectives: The aim of the present study was to assess how the various tasks involved in hair dyeing contribute to hairdressers' exposure to hair dye, in order to enable the formulation of well-founded recommendations on working routines that will reduce exposure and prevent occupational disease.

    Methods: Skin exposure to hair dye was measured for 20 hairdressers applying highlights and all-over hair colour with the hand rinsing technique. Read More

    An observational study on the effects of aviation turbine fuel and lubricants on the skin of Indian Air Force ground crew in flying stations.
    Med J Armed Forces India 2017 Jul 11;73(3):294-298. Epub 2016 Aug 11.
    Assistant Surgeon, O/o Deputy Director Medical Services (Leprosy), Collectorate, Salem District, Tamil Nadu 636001, India.
    Background: Ground crew of the Air Force routinely handle aviation turbine fuel (ATF) and lubricants and a need was felt to study the adverse effects of these substances on their skin so that remedial measures could be taken to prevent these adverse effects.

    Methods: A multi-centric, cross-sectional, observational study was performed at three Air Force flying stations. 109 ground crew members of the Indian Air Force (IAF) who were in direct contact with ATF and lubricants were screened for dermatological manifestations on exposed areas. Read More

    Skin diseases of the vulva: eczematous diseases and contact urticaria.
    J Obstet Gynaecol 2017 Aug 7:1-6. Epub 2017 Aug 7.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    Skin diseases in the vulvar area include a variety of disorders many of which have a chronic course with significant morbidity. It is important to be aware of the symptoms, signs and diagnostic tools in order to optimise treatment. Herein, the most common eczematous diseases of the vulvar area, i. Read More

    Atopic and Contact Dermatitis of the Vulva.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):371-378
    Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:
    Pruritus, or itch, is a common vulvar complaint that is often treated empirically as a yeast infection; however, yeast infections are just one of the many conditions that can cause vulvar itch. Ignoring other conditions can prolong pruritus unnecessarily. Atopic dermatitis, irritant contact dermatitis, and allergic contact dermatitis are extremely common noninfectious causes of vulvar itch that are often underdiagnosed by nondermatologists. Read More

    Dermatitis of the Foot: Epidemiologic and Clinical Features in 389 Children.
    Pediatr Dermatol 2017 Jul 21. Epub 2017 Jul 21.
    Dermatology Department, Valencia University General Hospital, Valencia, Spain.
    Background/objectives: Footwear dermatitis is a form of contact dermatitis resulting from exposure to shoes. There have been only small studies regarding foot contact dermatitis in children. The present study was undertaken to define the prevalence and epidemiologic and clinical features of shoe dermatitis in children. Read More

    A Case of Ischemia-Induced Perianal Ulceration Mimicking Pyoderma Gangrenosum.
    Skinmed 2017 1;15(3):235-237. Epub 2017 Jun 1.
    Department of Dermatology, Antrim Area Hospital, Antrim, Northern Ireland.
    A 68-year-old woman, with a 75-pack-year smoking history and a history of chronic excess alcohol intake, presented with a 5-week history of worsening perianal pain and ulceration. She recently had an inpatient admission with back pain and urinary tract infection during which she developed diarrhea and fecal incontinence. Initially, the perianal ulceration was diagnosed as severe irritant contact dermatitis and treated with barrier creams and topical clobetasone 17-butyrate 0. Read More

    Intestinal Stomas-Postoperative Stoma Care and Peristomal Skin Complications.
    Clin Colon Rectal Surg 2017 Jul 22;30(3):184-192. Epub 2017 May 22.
    Section of Colon and Rectal Surgery, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois.
    Intestinal stomas are necessary for several colon and rectal conditions and represent a major change in the new ostomate's daily life. Though dehydration is the most frequent etiology requiring readmission, irritant contact dermatitis and a host of other peristomal skin conditions are more common complications for ostomates. Wound, ostomy, and continence nurses are invaluable resources to both ostomy patients and providers. Read More

    Skin Health Connected to the Use of Absorbent Hygiene Products: A Review.
    Dermatol Ther (Heidelb) 2017 Jun 30. Epub 2017 Jun 30.
    SCA Hygiene Products AB, Göteborg, Sweden.
    Over the past 50 years, absorbent hygiene products such as baby diapers and incontinence products have become essential features of modern day life. Through innovation and enhanced technology, their design, composition and performance have been dramatically upgraded from their early forms, and they have transformed the lives of millions of people, improving their quality of life. Skin health related to the use of absorbent hygiene products has accordingly also greatly improved. Read More

    Minimum standards on prevention, diagnosis and treatment of occupational and work-related skin diseases in Europe - position paper of the COST Action StanDerm (TD 1206).
    J Eur Acad Dermatol Venereol 2017 Jun;31 Suppl 4:31-43
    Department of Dermatology, Hospital del Mar, Institut Mar d´Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona, Barcelona, Spain.
    Background: Skin diseases constitute up to 40% of all notified occupational diseases in most European countries, predominantly comprising contact dermatitis, contact urticaria, and skin cancer. While insufficient prevention of work-related skin diseases (WRSD) is a top-priority problem in Europe, common standards for prevention of these conditions are lacking.

    Objective: To develop common European standards on prevention and management of WRSD and occupational skin diseases (OSD). Read More

    Paederus dermatitis.
    Indian J Dermatol Venereol Leprol 2017 Jul-Aug;83(4):424-431
    Department of Ophthalmology, Karpaga Vinayaga Institute of Medical Sciences and Research Center, Madhuranthakam, Tamil Nadu, India.
    Paederus dermatitis is an irritant dermatitis caused by pederin, a toxin produced by the rove beetle (Paederus). The disease occurs worldwide, but it is often not recognized as a history of contact with the insect is frequently absent. It is commonly seen in the rainy season. Read More

    Management of Atopic Hand Dermatitis.
    Dermatol Clin 2017 Jul;35(3):365-372
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, Hellerup DK-2900, Denmark; National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, Hellerup DK-2900, Denmark. Electronic address:
    This article provides an overview of clinical aspects of hand eczema in patients with atopic dermatitis. Hand eczema can be a part of atopic dermatitis itself or a comorbidity, for example, as irritant or allergic contact dermatitis. When managing hand eczema, it is important to first categorize the subtype and identify potential culprit allergens or irritants. Read More

    A Descriptive Study to Explore the Effect of Peristomal Skin Complications on Quality of Life of Adults With a Permanent Ostomy.
    Ostomy Wound Manage 2017 May;63(5):10-23
    New York University Lutheran Medical Center, Brooklyn, NY.
    Approximately 1 million people are living with an ostomy, and 100 000 to 130 000 new ostomies are created each year. The exact incidence and prevalence of complications are unknown but have been reported to be as high as 70% and to affect quality of life (QoL). Using convenience sampling methods, a descriptive study was conducted to explore QoL scores and peristomal complications reported by adults with a permanent ostomy attending the 2009 United Ostomy Associations of America conference. Read More

    Dermatology in Ghana: a retrospective review of skin disease at the Korle Bu Teaching Hospital Dermatology Clinic.
    Pan Afr Med J 2017 3;26:125. Epub 2017 Mar 3.
    The Ronald Perelman Department of Dermatology, New York University School of Medicine, USA.
    Introduction: Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. Read More

    [Skin diseases associated with environmental factors].
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2017 Jun;60(6):605-617
    Abteilung Allergologie, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen, Deutschland.
    Background: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease.

    Objectives: Provide an overview of non-allergic skin diseases associated with environmental factors.

    Materials And Methods: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. Read More

    Dermatitis Due to Paederus Colombinus: Report of an Epidemic Outbreak of 68 Cases in the Province of Darien, Panama.
    Cureus 2017 Apr 12;9(4):e1158. Epub 2017 Apr 12.
    Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica De Pereira, Pereira, Risaralda, Colombia.
    Introduction: Contact dermatitis due to Paederus is a particular form of accident by animal contact. It is characterized by the sudden onset of erythematous and vesicular lesions with burning sensation on exposed areas of the body. The aim of this study was to describe the epidemiological and clinical findings of an outbreak of Paederus dermatitis in Panama. Read More

    Allergic and nonallergic rhinitis and skin sensitization to metals: is there a link?
    Eur Ann Allergy Clin Immunol 2017 May;49(3):106-109
    Allergy and Respiratory Diseases, IRCCS San Martino-Ist-University of Genoa, Genoa, Italy. Phone: +39 010 353 8904 E-mail:
    Summary: Background. Chromium, Cobalt and Nickel are responsible for contact dermatitis, that is largely prevalent in the general population. They can act also as irritants in the upper and lower respiratory airways. Read More

    Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis.
    Contact Dermatitis 2017 Jul 12;77(1):1-16. Epub 2017 May 12.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Read More

    Medical adhesive-related skin injuries associated with vascular access.
    Br J Nurs 2017 Apr;26(8):S4-S12
    Tissue Viability Lead Nurse, Imperial College Healthcare NHS Trust, London.
    Establishing vascular access and preventing infection, both at insertion and during ongoing care is generally the top priority; the maintenance of optimal skin integrity is often a distant secondary consideration. Skin can react to different types of dressings or adhesives, or problems can arise relating to the securement of lines or the development of sensitivities to cleaning solutions. Clearly, these scenarios are not limited to the securement of vascular access devices; however, a patient with a long-term vascular access device may not have other options for vascular access, which makes this a very important and yet largely unrecognised area. Read More

    Garlic Dermatitis on the Neck of an Infant Treated for Nasal Congestion.
    Pediatr Dermatol 2017 Jul 19;34(4):e212-e213. Epub 2017 Apr 19.
    Division of Dermatology, Ann and Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    The health benefits of garlic (Allium sativum) as a naturopathic remedy have been well documented, but topical application of garlic has been linked to allergic and irritant contact dermatitis. We present a case of severe irritant contact dermatitis due to application of a fresh garlic necklace to the neck of infant for treatment of nasal congestion. Read More

    Myths on Chemical Burns in the Diaper Area.
    Clin Pediatr (Phila) 2017 May;56(5_suppl):13S-15S
    1 Kenwood Dermatology, Cincinnati, OH, USA.
    Over the past several years, a number of articles and online posts have circulated on the Internet associating use of disposable and cloth diapers with chemical burns on babies' skin. Because both mild chemical burns and diaper dermatitis (diaper rash) can cause skin redness and peeling, it is not surprising that some confusion has arisen regarding the association between these two conditions. However, diapers cannot cause chemical burns because they are made of inert materials. Read More

    Differential Diagnosis of Diaper Dermatitis.
    Clin Pediatr (Phila) 2017 May;56(5_suppl):16S-22S
    1 Johns Hopkins Children's Center, Baltimore, MD, USA.
    Mild diaper dermatitis often occurs in children before toilet training is complete, particularly from 9 to 12 months of age, and the most common presentation is an irritant contact dermatitis. Diaper dermatitis may account for up to 25% of dermatology visits to health care providers during the first year of life. Fortunately, since the introduction of hypoallergenic, superabsorbent modern disposable diapers, the incidence and severity of irritant and allergic contact dermatitis has decreased dramatically. Read More

    Surgery-Related Contact Dermatitis: A Review of Potential Irritants and Allergens.
    J Allergy Clin Immunol Pract 2017 Apr 7. Epub 2017 Apr 7.
    Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, Calif.
    Surgical procedures utilize an increasing number of medical products including antiseptics, anesthetics, gloves, suture materials, tissue adhesives, topical antibiotics, and bandages. Many of these products have irritant potential. Allergic contact dermatitis has also been reported. Read More

    Occupational Contact Dermatitis in North American Production Workers Referred for Patch Testing: Retrospective Analysis of Cross-Sectional Data From the North American Contact Dermatitis Group 1998 to 2014.
    Dermatitis 2017 May/Jun;28(3):183-194
    From the *HCMC Parkside Occupational and Contact Dermatitis Clinic; †Department of Dermatology, Minneapolis Veterans Affairs Medical Center; and ‡Department of Dermatology, University of Minnesota Medical School, Minneapolis, MN; §Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; ∥Dartmouth-Hitchcock Medical Center, Lebanon, NH; ¶Division of Dermatology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada; #Department of Dermatology, Columbia University, New York, NY; **Ohio State University, Columbus; ††University of Louisville, KY; ‡‡Department of Dermatology, Cleveland Clinic, OH; §§Associates in Dermatology, Fort Myers, FL; ∥∥Department of Dermatology, Keck School of Medicine at University of Southern California, Los Angeles; ¶¶Department of Dermatology, Pennsylvania State University, State College; ##Division of Dermatology, University of Ottawa, Ontario, Canada; ***Department of Dermatology, University of California, San Francisco; and †††Department of Dermatology, University of Cincinnati, OH.
    Background: Little is known about the epidemiology of contact dermatitis in production workers (PWs).

    Objective: The aims of this study were to estimate the prevalence of contact dermatitis and characterize clinically relevant and occupationally related allergens among North American PWs undergoing patch testing.

    Methods: This was a retrospective cross-sectional analysis of North American Contact Dermatitis Group data from 1998 to 2014. Read More

    Stratum corneum profiles of inflammatory mediators in patch test reactions to common contact allergens and sodium lauryl sulfate.
    Br J Dermatol 2017 Jun 6;176(6):1533-1540. Epub 2017 Apr 6.
    Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, the Netherlands.
    Background: Recent studies have demonstrated allergen-specific differences in the gene expression of inflammatory mediators in patch tested skin.

    Objectives: To determine levels of various inflammatory mediators in the stratum corneum (SC) after patch testing with common contact allergens and the skin irritant sodium lauryl sulfate (SLS).

    Methods: In total, 27 individuals who had previously patch tested positive to nickel, chromium, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) or para-phenylenediamine were retested and then patch tested with SLS and petrolatum, with petrolatum serving as the patch test control. Read More

    North America Wound, Ostomy, and Continence and Enterostomal Therapy Nurses Current Ostomy Care Practice Related to Peristomal Skin Issues.
    J Wound Ostomy Continence Nurs 2017 May/Jun;44(3):257-261
    Janice C. Colwell, RN, MS, CWOCN, FAAN, University of Chicago Medicine, Chicago, Illinois. Laurie McNichol, MSN, RN, GNP, CWOCN, CWON-AP, FAAN, Cone Health, Wesley Long Hospital, Greensboro, North Carolina. Joy Boarini, MSN, WOC Nurse, (retired). At the time this article was written she was the Director of Global Clinical Education for Hollister Incorporated. Global Clinical Education, Hollister Incorporated, Libertyville, Illinois.
    Purpose: The purpose of this study was to describe the practice of 796 ostomy nurses in North America in 2014 related to peristomal skin issues.

    Design: Descriptive study.

    Subjects And Setting: Participants were 796 wound, ostomy, and continence (WOC) and enterostomal therapy (ET) nurses currently practicing in the United States or Canada and caring for patients with ostomies. Read More

    Debunking the Myth of Wool Allergy: Reviewing the Evidence for Immune and Non-immune Cutaneous Reactions.
    Acta Derm Venereol 2017 Mar 28. Epub 2017 Mar 28.
    Department of Dermatology, Monash University, Eastern Health, Box Hill Victoria; Murdoch Childrens Research Institute, Victoria, 3168 Melbourne, Australia.
    Although wool is commonly believed to cause irritant (non-immune) and hypersensitivity (immune) cutaneous reactions, the evidence basis for this belief and its validity for modern garments have not been critically examined. Publications from the last 100 years, using MEDLINE and Google Scholar, were analysed for evidence that wool causes cutaneous reactions, both immune-mediated (atopic dermatitis exacerbation, contact urticaria, allergic contact dermatitis) and non-immune-mediated (irritant contact dermatitis, itch). Secondary aims of this paper were to examine evidence that lanolin and textile-processing additives (formaldehyde, chromium) cause cutaneous reactions in the context of modern wool-processing techniques. Read More

    Perianal Dermatitis.
    Dermatitis 2017 Jul/Aug;28(4):270-275
    From the Department of Dermatology, Complejo Hospitalario de Navarra, Pamplona, Spain.
    Background: Perianal complaints are often consulted in dermatology clinics, and in many cases, a conclusive diagnosis is not easily made.

    Objective: The aim of this study was to study and identify the epidemiological, clinical, and contact allergy features of patients with perianal dermatitis who attended at a contact dermatitis unit in a tertiary hospital in Spain.

    Methods: Adult patients with long-lasting (>4 weeks) perianal dermatitis were recruited during the past 10 years for investigation and follow-up. Read More

    Occupational Contact Dermatitis in North American Print Machine Operators Referred for Patch Testing: Retrospective Analysis of Cross-Sectional Data From the North American Contact Dermatitis Group 1998 to 2014.
    Dermatitis 2017 May/Jun;28(3):195-203
    From the *HCMC Parkside Occupational and Contact Dermatitis Clinic and Department of Dermatology, Minneapolis Veterans Affairs Medical Center; and †Department of Dermatology, University of Minnesota Medical School, Minneapolis; ‡Department of Dermatology, Columbia University, New York, NY; §Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; ∥Department of Dermatology, University of California San Francisco; ¶Department of Dermatology, University of Cincinnati, OH; #Dartmouth-Hitchcock Medical Center, Lebanon, NH; **Division of Dermatology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada; ††Ohio State University, Columbus; ‡‡University of Louisville, KY; §§Associates in Dermatology, Fort Myers, FL; ∥∥Department of Dermatology, Keck School of Medicine at University of Southern California, Los Angeles; ¶¶Department of Dermatology, Pennsylvania State University, State College; ##Division of Dermatology, University of Ottawa, Ontario, Canada; and ***Department of Dermatology, Cleveland Clinic, OH.
    Background: Little is known about the epidemiology of contact dermatitis (CD) in print machine operators (PMOs).

    Objective: The aims of this study were to estimate the prevalence of CD and characterize clinically relevant and occupationally related allergens among PMOs undergoing patch testing.

    Methods: This was a retrospective cross-sectional analysis of the North American Contact Dermatitis Group data from 1998 to 2014. Read More

    The potential benefits of using aloe vera in stoma patient skin care.
    Br J Nurs 2017 Mar;26(5):S12-S19
    Professor and Director for the Institute of Skin Integrity and Infection Prevention, School of Human and Health Sciences, University of Huddersfield.
    Individuals living with an ostomy may suffer from a variety of peri-stomal skin complications related to the use of their stoma appliance or accessories. These conditions can be serious enough to significantly impact on a patient's quality of life and may result in severe clinical complications (such as infection). This article is a review of the literature with the objective of investigating and presenting evidence for the well-documented use of aloe vera in the prevention of skin conditions similar to those seen in peri-stomal skin complications. Read More

    Histomorphology and Immunophenotype of Eczematous Skin Lesions Revisited-Skin Biopsies Are Not Reliable in Differentiating Allergic Contact Dermatitis, Irritant Contact Dermatitis, and Atopic Dermatitis.
    Am J Dermatopathol 2017 Mar 10. Epub 2017 Mar 10.
    *Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany; †Dermatologikum Hamburg, Hamburg, Germany; and ‡Department of Dermatology, Venereology and Allergology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
    Lesions of allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), and atopic dermatitis (AD) share similar clinical features and thus, their diagnosis can be challenging. The aim of this study was to reassess histopathology and immunophenotyping properties to distinguish between ACD, ICD, and AD. Charts of patients with eczema, who had undergone complete routine diagnostic workup (skin biopsies, patch tests, skin prick tests, and respectively or serum IgE levels), were reviewed. Read More

    Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology.
    Contact Dermatitis 2017 May 14;76(5):287-295. Epub 2017 Mar 14.
    Academic Medical Center, Department: Coronel institute of Occupational Health, Amsterdam Public Health Research Institute, 1105 AZ Amsterdam, The Netherlands.
    Background: The irritant sodium lauryl sulfate (SLS) is known to cause a decrease in the stratum corneum level of natural moisturizing factor (NMF), which in itself is associated with changes in corneocyte surface topography.

    Objective: To explore this phenomenon in allergic contact dermatitis.

    Methods: Patch testing was performed on patients with previously positive patch test reactions to potassium dichromate (Cr), nickel sulfate (Ni), methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI), or p-phenylenediamine. Read More

    A comparison of the effect of certain inorganic salts on suppression acute skin irritation by human biometric assay: A randomized, double-blind clinical trial.
    J Res Med Sci 2016 2;21:102. Epub 2016 Nov 2.
    Department of Cell and Molecular Biology, Royan Institute for Animal Biotechnology, Isfahan, Iran.
    Background: Strontium, zinc, and potassium salts have been demonstrated to inhibit irritation and inflammation when applied topically. Particularly, strontium chloride (SC) and potassium nitrate (KN) are reported to reduce skin and tooth sensitivity. The aim of the present study was to compare the anti-irritant effects of four inorganic salts and assign the ingredient which can suppress skin irritation due to chemical or environmental exposure, more effectively. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Development of an in vitro method to estimate the sensitization induction level of contact allergens.
    Toxicol Lett 2017 Apr 9;271:1-11. Epub 2017 Feb 9.
    Laboratory of Toxicology, DiSFeB, Università degli Studi di Milano, Milan, Italy. Electronic address:
    No standardized in vitro methods to assess potency of skin sensitizers are available. Recently, we standardized a procedure which combines the epidermal equivalent potency assay with assessment of IL-18 to provide a single test for identification and classification of skin sensitizers. This current study aimed to extend tested chemicals, and to provide a simple in vitro method for estimation of the expected sensitization induction level interpolating in vitro EC50 and IL-18 SI2 values to predict LLNA EC3 and/or human NOEL from standards curves generated using reference contact allergens. Read More

    Dermatoses among automobile mechanics in Mansoura, Egypt.
    Arch Environ Occup Health 2017 Feb 3:1-6. Epub 2017 Feb 3.
    b Department of Dermatology , Andrology and STDs, Faculty of Medicine, Mansoura University , Mansoura , Egypt.
    This cross-sectional study was carried out in Mansoura, Egypt to assess the prevalence of occupational dermatoses and their possible risk factors on a convenience sample of car mechanics. Sociodemographic and occupational data were collected, and clinical examination was done. Prevalence of skin diseases was 45. Read More

    The Endocannabinoid System and Its Role in Eczematous Dermatoses.
    Dermatitis 2017 Jan/Feb;28(1):22-32
    From the *Drexel University College of Medicine, Philadelphia, PA; †School of Medicine, ‡Department of Dermatology, University of California, Davis; and §Dermatology Division, Department of Medicine, University of Arizona, Tucson.
    The skin serves as the foremost barrier between the internal body and the external world, providing crucial protection against pathogens and chemical, mechanical, and ultraviolet damages. The skin is a central player in the intricate network of immune, neurologic, and endocrine systems. The endocannabinoid system (ECS) includes an extensive network of bioactive lipid mediators and their receptors, functions to modulate appetite, pain, mood, and memory, and has recently been implicated in skin homeostasis. Read More

    Managing Occupational Irritant Contact Dermatitis Using a Two-Step Skincare Regimen Designed to Prevent Skin Damage and Support Skin Recovery.
    J Drugs Dermatol 2016 Dec;15(12):1504-1510
    Occupational irritant contact dermatitis (ICD) affecting the hands is a common and difficult-to-manage condition. Occupations that necessitate contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing elevate the risk of ICD. Management strategies that do not adequately prevent accumulated damage and repair skin, can develop into chronic dermatoses which negatively impact work productivity and quality of life. Read More

    Efficacy of a Hand Regimen in Skin Barrier Protection in Individuals With Occupational Irritant Contact Dermatitis.
    J Drugs Dermatol 2016 Nov;15(11):s81-s85
    Background: Occupational irritant contact dermatitis (OICD) is a dif cult and hard to manage condition. It occurs more frequently in certain occupations where contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing heightens the risk. Treatment for OICD includes patient education in addition to physical, topical, and systemic therapies. Read More

    Evaluation of in vitro assays for the assessment of the skin sensitization hazard of functional polysiloxanes and silanes.
    Regul Toxicol Pharmacol 2017 Mar 23;84:64-76. Epub 2016 Dec 23.
    Dow Corning Corporation, Health and Environmental Sciences, 2200 West Salzburg Road, Auburn, MI 48611, United States.
    The skin sensitization potential of chemicals has traditionally been evaluated in vivo according to OECD testing guidelines in guinea pigs or the mouse local lymph node assay. There has lately been a great emphasis on establishing in vitro test methods reflecting the key biological events in the adverse outcome pathway (AOP) for skin sensitization as published by the OECD. Against this background, a group of 8 polysiloxanes and silanes, seven of them aminofunctionalised, for which in vivo data were already available, has been tested in vitro in the direct peptide reactivity assay (DPRA), the KeratinoSens™ and the human cell line activation test (h-CLAT) and in the modified myeloid U937 skin sensitization test (mMUSST) as far as technically feasible. Read More

    Biomimetic proopiomelanocortin suppresses capsaicin-induced sensory irritation in humans.
    Res Pharm Sci 2016 Dec;11(6):484-490
    Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
    Sensitive skin is a frequently mentioned cosmetic complaint. Addition of a biomimetic of neuromediator has recently appeared as a promising new way to cure skin care product problems. This study was aimed to assess the inhibitory effect of a biomimetic lipopeptide derived from proopiomelanocortin (bPOMC) on capsaicin-induced sensory irritation in human volunteers and also to compare its protective effect with that of the well-known anti irritant strontium chloride. Read More

    Patch Test Series for Allergic Perineal Dermatitis in the Diapered Infant.
    Dermatitis 2017 Jan/Feb;28(1):70-75
    From the *Section of Pediatric Dermatology, Children's Hospital of Philadelphia, PA; and †Department of Dermatology, University of Pennsylvania, Philadelphia.
    Background: Allergic perineal dermatitis (PD) due to diaper wipes, topical medicaments, or diapers has been reported. Although patch testing is the criterion standard for detection of allergic contact dermatitis in children, this is limited by body surface area, decreased tolerance of the patch testing procedure, and increased false-positive rates due to irritant reactions. Therefore, a targeted patch testing series is necessary to better screen diapered infants for possible allergic PD. Read More

    A new treatment regimen with permethrin in scabies.
    G Ital Dermatol Venereol 2016 Dec 16. Epub 2016 Dec 16.
    Postgraduate School of Dermatology and Venereology, University of Milan, Milan, Italy.
    Background: Topical permethrin, applied once daily, is considered as the most effective treatment in scabies.

    Methods: Eighty-nine adult immunocompetent patients with scabies were treated with 5% permethrin cream: 42 patients were treated with a single application/day (group I); 47 patients were treated with one application/day for two consecutive days (group II). Clinical diagnosis of scabies was confirmed by microscopical examinations. Read More

    Skin targeting of resveratrol utilizing solid lipid nanoparticle-engrossed gel for chemically induced irritant contact dermatitis.
    Drug Deliv Transl Res 2017 Feb;7(1):37-52
    Sinhgad College of Pharmacy, Vadgaon(Bk.), Pune S. No 44/1, Vadgaon (Bk), Off Sinhgad Road, Pune, MS, 411041, India.
    Irritant contact dermatitis (ICD) is a chronic and relapsing skin disease with severe eczematous lesions. Despite its growing prevalence, therapeutic treatments remain limited. Long-term topical corticosteroid treatment can induce skin atrophy, hypopigmentation, and increase in transepidermal water loss. Read More

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