5,219 results match your criteria Contact Dermatitis Irritant


Contact allergens in moisturizers in preventative emollient therapy - A systematic review.

Clin Transl Allergy 2022 Jun 5;12(6):e12150. Epub 2022 Jun 5.

Department of Pediatric Pneumonology and Allergy Medical University of Warsaw Warsaw Poland.

Background: Results of preventative emollient therapy on atopic dermatitis and food allergy trials are inconsistent. In addition to the ingredients considered beneficial, the moisturizers may contain potentially harmful haptens. This study aimed to assess the prevalence of haptens in moisturizers used in studies to prevent atopic dermatitis or food allergy and assess their correlations to the trial results. Read More

View Article and Full-Text PDF

Comparison of product safety data sheet ingredient lists with skin irritants and sensitizers present in a convenience sample of light-curing resins used in additive manufacturing.

Regul Toxicol Pharmacol 2022 May 31;133:105198. Epub 2022 May 31.

National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV, 26505, USA.

Material jetting and vat photopolymerization additive manufacturing (AM) processes use liquid resins to build objects. These resins can contain skin irritants and/or sensitizers but product safety data sheets (SDSs) might not declare all ingredients. We characterized elemental and organic skin irritants and sensitizers present in 39 commercial products; evaluated the influence of resin manufacturer, system, color, and AM process type on the presence of irritants and sensitizers; and compared product SDSs to results. Read More

View Article and Full-Text PDF

Contact dermatitis in children caused by diabetes devices.

Contact Dermatitis 2022 May 30. Epub 2022 May 30.

Department of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark.

Background: Insulin pumps and glucose monitoring devices improve diabetes mellitus control and enhance patients' quality of life. However, a growing number of adverse cutaneous reactions related to the use of these devices have been reported.

Objective: To investigate the culprits of localized contact dermatitis in paediatric patients with diabetes caused by insulin pumps and glucose monitoring devices. Read More

View Article and Full-Text PDF

Keratinocytes: An Enigmatic Factor in Atopic Dermatitis.

Cells 2022 05 19;11(10). Epub 2022 May 19.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Kolkata, Chunilal Bhawan, 168 Maniktala Main Road, Kolkata 700054, West Bengal, India.

Atopic dermatitis (AD), characterized by rashes, itching, and pruritus, is a chronic inflammatory condition of the skin with a marked infiltration of inflammatory cells into the lesion. It usually commences in early childhood and coexists with other atopic diseases such as allergic rhinitis, bronchial asthma, allergic conjunctivitis, etc. With a prevalence rate of 1-20% in adults and children worldwide, AD is gradually becoming a major health concern. Read More

View Article and Full-Text PDF

Cutaneous Allergic reactions to pine processionary caterpillar (Thaumetopoea Pityocampa): a complicated cutaneous reaction in an infant and review of the literature.

Turk J Pediatr 2022 ;64(2):389-393

Division of Pediatric Allergy & Immunology, Near East University, Faculty of Medicine, Nicosia, North Cyprus.

Background: Thaumetopoea Pityocampa (TP) are frequent in the Mediterranean region especially affecting forest workers in pinewood areas. The common symptoms include swelling, rash or burns like any form of dermatitis. The reactions can be triggered by mechanical, chemical or allergic factors and the `allergic` reaction is caused by sensitization to a hair protein named `thaumetopoein`. Read More

View Article and Full-Text PDF

A post-operative reaction to povidone‑iodine in a postpartum woman: A case report.

Case Rep Womens Health 2022 Apr 3;34:e00394. Epub 2022 Feb 3.

Texas Tech University Health Sciences Center at the Permian Basin, 800 W 4 Street, Odessa, TX 79763, USA.

Introduction: High infection rates after cesarean section are a major concern in the United States. A majority of antiseptics have irritant properties if they are not used as specified in companies' guidelines. Allergic contact dermatitis caused by povidone‑iodine is infrequent and is misdiagnosed by clinicians who fail to differentiate allergy from irritation. Read More

View Article and Full-Text PDF

Sulfur spring dermatitis, more than a thermal burn injury.

J Pediatr 2022 May 9. Epub 2022 May 9.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taipei, Taoyuan, Keelung, Taiwan; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. Electronic address:

View Article and Full-Text PDF

Skin symptoms in veterinary assistant staff and veterinarians: A cross-sectional study.

Contact Dermatitis 2022 May 8. Epub 2022 May 8.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany.

Background: Veterinary assistants and veterinarians are at an increased risk of developing an occupational skin disease, for example, irritant/allergic contact dermatitis, contact urticaria and hand eczema (HE).

Objectives: We aimed to investigate the prevalence of skin problems and the influence of predisposing factors especially among veterinary assistants.

Methods: We conducted a cross-sectional study among veterinary assistant staff (n = 103) and veterinarians (n = 19). Read More

View Article and Full-Text PDF

German S1 guideline: Contact dermatitis.

J Dtsch Dermatol Ges 2022 05 8;20(5):712-734. Epub 2022 May 8.

Center of IVDK, University Medical Center Göttingen, Göttingen, Germany.

Contact dermatitis is an inflammation of the epidermis and dermis at the site of exposure triggered by external agents. The two main forms are irritant and allergic contact dermatitis, which cause significant health and socioeconomic costs in addition to a marked reduction in quality of life. The anamnesis and the clinical picture are decisive for the necessary diagnostic measures. Read More

View Article and Full-Text PDF

Epidemiological, Clinical, and Allergy Profile of Patients With Atopic Dermatitis and Hand Eczema: Evaluation of the Spanish Contact Dermatitis Registry (REIDAC).

Actas Dermosifiliogr 2022 Mar 24;113(3):236-243. Epub 2021 Oct 24.

Hospital Universitari Germans Trias i Pujol.

Background: Hand eczema is common in patients with atopic dermatitis (AD), but few studies have described the characteristics of these patients in large, representative populations from different geographic regions and occupational settings.

Objective: To describe the epidemiological, clinical, and allergy profile of patients with hand eczema who underwent patch testing and compare patients with and without AD.

Methods: Analysis of data from the Spanish Contact Dermatitis Registry, a multicenter registry of patients who undergo patch testing in Spain. Read More

View Article and Full-Text PDF

Moisture-Associated Skin Damage: Expanding Practice Based on the Newest ICD-10-CM Codes for Irritant Contact Dermatitis Associated With Digestive Secretions and Fecal or Urinary Effluent From an Abdominal Stoma or Enterocutaneous Fistula.

J Wound Ostomy Continence Nurs 2022 May-Jun 01;49(3):235-239

Laurie McNichol, MSN, RN, CNS, GNP, CWOCN, CWON-AP, FAAN, WOC Nurse, Cone Health, Greensboro, North Carolina.

Moisture-associated skin damage (MASD) occurs when skin is repeatedly exposed to various sources of bodily secretions or effluents, often leading to irritant contact dermatitis, characterized by inflammation with or without denudation of affected skin. In 2020, the Wound, Ostomy and Continence Nurses Society commissioned an initiative that led to the addition of multiple International Classification of Diseases, Tenth Revision, Clinical Modification codes (ICD-10-CM) for irritant contact dermatitis caused by various forms of MASD for use in the United States. In a recent issue of the Journal of Wound, Ostomy and Continence Nursing, a clinical practice alert identifying the various new codes was published that summarized each of the new codes and provided highlights of the descriptions for each of these codes. Read More

View Article and Full-Text PDF

Contact Dermatitis in the Surgical Patient: A Focus on Wound Closure Materials.

Dermatitis 2022 Apr 28. Epub 2022 Apr 28.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, NY.

Abstract: Irritant and allergic contact dermatitis from wound closure materials can occur in patients after surgical procedures. The resulting inflammation from contact dermatitis can compromise wound healing, mimic surgical site infections, and result in wound dehiscence. Components of wound closure material, such as antibiotic coatings, dyes, sterilizing compounds, or the material itself, have been implicated as contact allergens. Read More

View Article and Full-Text PDF

Skin injuries due to Personal Protective Equipment and preventive measures in the COVID-19 context: an integrative review.

Rev Lat Am Enfermagem 2022 20;30:e3551. Epub 2022 Apr 20.

Universidade Federal do Maranhão, Centro de Ciências Sociais, Saúde e Tecnologia, Imperatriz, MA, Brasil.

Objective: to identify the diverse scientific evidence on the types of skin lesions caused due to the use of Personal Protective Equipment in health professionals during the COVID-19 pandemic and to verify the recommended prevention measures.

Method: this is an integrative review carried out in the MEDLINE, CINAHL, LILACS, SCOPUS, Science Direct, Web of Science and SciELO databases. The search was conducted in a paired manner, constituting a sample of 17 studies categorized according to the types of skin lesions and preventive measures. Read More

View Article and Full-Text PDF

Irritant contact dermatitis caused by cosmetics containing excessive mercury.

J Cosmet Dermatol 2022 Apr 21. Epub 2022 Apr 21.

Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Irritant contact dermatitis (ICD) is a localized, non-immune-induced inflammatory skin reaction, characterized by multiform skin lesions, including erythema, scaling, edema, blisters, and erosion. Mercury and its related compounds are highly allergic agents that can induce allergic contact dermatitis. However, the case of ICD, caused by cosmetic whitening products containing high levels of mercury, is extremely rare. Read More

View Article and Full-Text PDF

Irritant Contact Dermatitis - a Review.

Curr Dermatol Rep 2022 7;11(2):41-51. Epub 2022 Apr 7.

Occupational Dermatology Research and Education Centre, Skin Health Institute, Level 1/80 Drummond Street, Carlton, 3053 Australia.

Purpose Of Review: Irritant contact dermatitis is the most common form of contact dermatitis and the most common occupational skin disease. This review provides a comprehensive summary of the endogenous and exogenous factors that play a role in the pathogenesis of irritant contact dermatitis.

Recent Findings: In conjunction with avoidance of irritants, barrier protection, and regular application of moisturizers, management now emphasizes the importance of primary prevention through educational initiatives in high-risk workplaces. Read More

View Article and Full-Text PDF

The optimal use of chlormethine gel for mycosis fungoides: An expert consensus from Germany, Austria and Switzerland (DACH region).

J Dtsch Dermatol Ges 2022 05 15;20(5):579-586. Epub 2022 Apr 15.

Department of Dermatology and Venereology, University Hospital St. Pölten, Karl Landsteiner University of Health Sciences, St. Pölten, Austria.

Background: In Europe chlormethine gel is licensed for the management of patients with mycosis fungoides of all stages. However, the optimal regimen regarding frequency and dosing as well as combination and maintenance therapy is not well established.

Methods: Ten experts experienced in research and management of cutaneous T-cell lymphomas from Germany, Austria, and Switzerland (DACH region) were asked in written form to report on indication for chlormethine gel, frequency of use, monitoring, concomitant therapies, adverse effects, combination therapies in later stages of the disease, maintenance therapy, and adherence to this therapy for mycosis fungoides. Read More

View Article and Full-Text PDF

Nickel dust-induced occupational contact dermatitis by welding and grinding work in shipyard workers: a report of nine cases.

Ann Occup Environ Med 2022 24;34:e7. Epub 2022 Mar 24.

Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Background: Occupational skin diseases are skin conditions that occur or worsen in relation to work and known to be the second most common type of occupational disease affecting individuals in the United States. In Korea, epidemiological reports related to occupational skin diseases are rare. But, no cases of occupational contact dermatitis caused by welding and grinding work have been reported previously. Read More

View Article and Full-Text PDF

Keratolysis exfoliativa-like eruption induced by ranolazine.

Dermatol Reports 2022 Mar 22;14(1):9264. Epub 2022 Mar 22.

Dermatology Unit, San Bortolo Hospital, Vicenza, Italy.

Dermatoses affecting palms may represent a dermatologic challenge from both the diagnostic, and therapeutic point of view. Patients with supposedly occupational dermatitis can spend months or even years in a frustrating attempt to avoid contact with possible irritants or allergens. To underline the importance of a thorough unbiased analysis of the patient's history and clinical features, we present the iconic case of a bricklayer affected by a chronic, disabling desquamation of palms which in the end was classified as keratolysis exfoliativa (KE) attributed to ranolazine-intake, an antianginal drug. Read More

View Article and Full-Text PDF

Technologies for Type 1 Diabetes and Contact Dermatitis: Therapeutic Tools and Clinical Outcomes in a Cohort of Pediatric Patients.

Front Endocrinol (Lausanne) 2022 15;13:846137. Epub 2022 Mar 15.

Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.

The increasing use of technological devices for the management of diabetes is related to the prolonged exposure of patients' skin to chemical and mechanical agents and, consequently, to the increased risk of developing dermatological complications. Among these, contact dermatitis is the most insidious skin disorder. Despite the magnitude of the issue, no universally accepted recommendations on the management of this common complication are currently available. Read More

View Article and Full-Text PDF

What We Have Learned-Milestones in Pediatric Contact Dermatitis.

Curr Dermatol Rep 2022 26;11(1):1-12. Epub 2022 Mar 26.

Department of Dermatology, University of Nebraska Medical Center, Omaha, NE USA.

Purpose Of Review: This review highlights recent developments in the field of pediatric allergic contact dermatitis (ACD) and patch testing. We will review updates on the pathophysiology of contact dermatitis, discuss new contact allergens, explore the impact of dupilumab on patch testing, and provide pearls for the diagnosis and management of ACD in children.

Recent Findings: ACD is not a single immunologic phenomenon but rather has contributions from multiple inflammatory pathways. Read More

View Article and Full-Text PDF

Effects of skin washing frequency on the epidermal barrier function and inflammatory processes of the epidermis: An experimental study.

Contact Dermatitis 2022 Mar 31. Epub 2022 Mar 31.

Department of Dermatology, Environmental Medicine and Health Theory, Osnabrück University, Osnabrück, Germany.

Background: Increased hand hygiene measures during the COVID-19 pandemic have led to an increased quantum of hand eczema (HE).

Objectives: To examine the effects of varying washing frequencies using current mild cleansing agents-alongside with the effect of a rehydrating cream-on the epidermal barrier function and inflammatory processes of the stratum corneum(SC).

Methods: Standardized skin washings on the volar aspects of the lower arms of skin-healthy volunteers were performed using the automated cleansing device either 5 or 11 times within 4 h for 60 s each with a standard cleanser, a lipid-containing syndet, or a lipid-containing syndet followed by one-time application of a rehydrating cream. Read More

View Article and Full-Text PDF

Contact allergens for the allergist.

Ann Allergy Asthma Immunol 2022 Jun 25;128(6):629-644. Epub 2022 Mar 25.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, New York University Langone Hospital-Long Island, Mineola, New York; New York University Long Island School of Medicine, Mineola, New York.

Objective: The objective of this article is to provide an overview and describe typically encountered skin contact allergens implicated in allergic contact dermatitis (ACD).

Data Sources: Published literature obtained through textbooks, online PubMed, and Google Scholar database searches, author photography, and adapted figures were used.

Study Selections: Studies on the evaluation of ACD and specific skin contact allergens were selected, with a focus on original research articles and clinical reviews. Read More

View Article and Full-Text PDF

Allergic Contact Dermatitis of the Scalp Associated With Scalp Applied Products: A Systematic Review of Topical Allergens.

Dermatitis 2022 Mar 22. Epub 2022 Mar 22.

From the Department of Dermatology, University of California, Irvine Department of Dermatology, Stanford University, CA.

Abstract: Hair products are commonly used to maintain hair health or cosmesis. Products applied to the scalp and hair contain multiple active and inactive ingredients that can potentially cause irritant and/or allergic contact dermatitis. The objectives of this study were to identify and to discuss the most common allergens in scalp and hair applied products causing scalp allergic contact dermatitis (ACD). Read More

View Article and Full-Text PDF

Quantification of preservatives in tattoo and permanent make-up inks in the frame of the new requirements under the REACH Regulation.

Contact Dermatitis 2022 Mar 15. Epub 2022 Mar 15.

National Centre for Chemicals, Cosmetics and Consumer Health Protection, Istituto Superiore di Sanità, Rome, Italy.

Background: According to the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) restriction, tattoo and permanent make-up (PMU) inks placed on the European Union market after January 4, 2022, shall not contain methylisothiazolinone, benzisothiazolinone (BIT), octylisothiazolinone (OIT), or other skin sensitizers in concentrations of 10 mg/kg or higher and phenoxyethanol (PE) or other eye irritants or damaging substances in concentrations of 100 mg/kg or higher. In addition, preservatives and other substances enlisted in Annex II to Cosmetic Product Regulation shall not be present in concentrations of 0.5 mg/kg or higher. Read More

View Article and Full-Text PDF

Healing of a Large Wound Defect Post Debridement, with PRF Therapy and High Dose Oral Vitamin C, in a Patient of Severe Irritant Contact Dermatitis Due to Slaked Lime: A Case Report.

Authors:
Shashank Bansod

J Cutan Aesthet Surg 2021 Oct-Dec;14(4):420-425

Hi-Tech Skin Clinic and Hair Transplant Centre, Nagpur, Maharashtra, India.

Platelet-rich blood concentrates have been used to accelerate healing process in wounds and in bones since many decades worldwide. Platelet-rich fibrin (PRF) is a relatively new and established therapy, utilizing platelets and leucocytes trapped in fibrin matrix, for the treatment of non-healing ulcers and wounds. Many large series are available in this subject to prove its efficacy. Read More

View Article and Full-Text PDF

Contact Allergy to Ammonium Persulfate: An Epidemiologic Study of 2138 Consecutive Dermatitis Patients.

Indian J Dermatol 2021 Nov-Dec;66(6):616-619

Department of Dermatology, Brigham and Women's Hospital, Boston, USA.

Background: Persulfate is an oxidizing agent used for multiple purposes, including bleaching hair, bleaching flour, and as pool/spa water disinfectant.

Objective: To identify the prevalence and clinical characteristics of patients allergic to ammonium persulfate (APS) among patients who underwent patch testing in our clinic.

Methods: A retrospective chart review of 2138 patients who underwent patch testing at Brigham and Women's hospital in Boston between July 2015 to November 2019. Read More

View Article and Full-Text PDF

Moisture-Associated Skin Damage: Expanding and Updating Practice Based on the Newest ICD-10-CM Codes.

J Wound Ostomy Continence Nurs 2022 Mar-Apr 01;49(2):143-151

Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville.

Moisture-associated skin damage (MASD) occurs when skin is repeatedly exposed to various sources of bodily secretions or effluents, often leading to irritant contact dermatitis with inflammation, with or without denudation of affected skin. In 2020, the Wound, Ostomy and Continence Nurses Society took an initiative that led to the addition of multiple International Classification for Diseases codes for irritant contract dermatitis caused by various forms of MASD for use in the United States (ICD-10-CM). In the last issue of the Journal of Wound, Ostomy and Continence Nursing, a clinical practice alert identifying the various new codes was published that summarized each of the new codes and provided highlights of the descriptions of each of the these codes. Read More

View Article and Full-Text PDF

Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.

J Immunol 2022 03 23;208(6):1424-1433. Epub 2022 Feb 23.

Immunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China;

NF-erythroid 2-related factor 2 (Nrf2) is a major transcription factor to protect cells against reactive oxygen species (ROS) and reactive toxicants. Meanwhile, Nrf2 can inhibit contact dermatitis through redox-dependent and -independent pathways. However, the underlying mechanisms of how Nrf2 mediates irritant contact dermatitis (ICD) are still unclear. Read More

View Article and Full-Text PDF

Impact in Contact Dermatitis during and after SARS-CoV2 Pandemic.

Curr Treat Options Allergy 2022 10;9(1):19-26. Epub 2022 Feb 10.

Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131 Naples, Italy.

Purpose Of The Review: Due to the recent COVID-19 pandemic, several skin conditions have emerged due to the preventive measures adopted by both health care workers and the general population against SARS-CoV-2. Above all, wearing of personal protective equipment, frequent hand-washing and disinfecting of surfaces have resulted in an increased risk of irritant or allergic contact dermatitis. The aim of this review is to investigate contact dermatitis associated with COVID-19 pandemic period. Read More

View Article and Full-Text PDF
February 2022

Gene profiling reveals a contact allergy signature in most positive Amerchol L-101 patch test reactions.

Contact Dermatitis 2022 Jul 25;87(1):40-52. Epub 2022 Mar 25.

CIRI, Centre International de Recherche en Infectiologie, (Team Epidermal Immunity and Allergy); Univ Lyon; Inserm, U1111, Université Claude Bernard Lyon 1; CNRS, UMR5308; ENS de Lyon, Lyon, France.

Background: Diagnosis of contact allergy (CA) to Amerchol L-101 (AL-101), a marker for lanolin allergy, is problematic. Positive patch test reactions are frequently doubtful or weakly positive and difficult to associate with clinical relevance.

Objective: To gain further insight on the allergic or irritant nature of skin reactions induced by AL-101 patch test. Read More

View Article and Full-Text PDF