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    1 OF 90

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Dermatoses among automobile mechanics in Mansoura, Egypt.
    Arch Environ Occup Health 2017 Feb 3. Epub 2017 Feb 3.
    c MD of Dermatology, Andrology and STDs, Department of Dermatology , Andrology and STDs, Faculty of Medicine, Mansoura University , Mansoura , Egypt .
    This cross-sectional study was carried out in Mansoura city, Egypt to assess the prevalence of occupational dermatoses and their possible risk factors on a convenience sample of car mechanics. Socio-demographic and occupational data were collected, and clinical examination was done. Prevalence of skin diseases was 45. Read More

    The Endocannabinoid System and Its Role in Eczematous Dermatoses.
    Dermatitis 2017 Jan/Feb;28(1):22-32
    From the *Drexel University College of Medicine, Philadelphia, PA; †School of Medicine, ‡Department of Dermatology, University of California, Davis; and §Dermatology Division, Department of Medicine, University of Arizona, Tucson.
    The skin serves as the foremost barrier between the internal body and the external world, providing crucial protection against pathogens and chemical, mechanical, and ultraviolet damages. The skin is a central player in the intricate network of immune, neurologic, and endocrine systems. The endocannabinoid system (ECS) includes an extensive network of bioactive lipid mediators and their receptors, functions to modulate appetite, pain, mood, and memory, and has recently been implicated in skin homeostasis. Read More

    Managing Occupational Irritant Contact Dermatitis Using a Two-Step Skincare Regimen Designed to Prevent Skin Damage and Support Skin Recovery.
    J Drugs Dermatol 2016 Dec;15(12):1504-1510
    Occupational irritant contact dermatitis (ICD) affecting the hands is a common and difficult-to-manage condition. Occupations that necessitate contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing elevate the risk of ICD. Management strategies that do not adequately prevent accumulated damage and repair skin, can develop into chronic dermatoses which negatively impact work productivity and quality of life. Read More

    Efficacy of a Hand Regimen in Skin Barrier Protection in Individuals With Occupational Irritant Contact Dermatitis.
    J Drugs Dermatol 2016 Nov;15(11):s81-s85
    Background: Occupational irritant contact dermatitis (OICD) is a dif cult and hard to manage condition. It occurs more frequently in certain occupations where contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing heightens the risk. Treatment for OICD includes patient education in addition to physical, topical, and systemic therapies. Read More

    Biomimetic proopiomelanocortin suppresses capsaicin-induced sensory irritation in humans.
    Res Pharm Sci 2016 Dec;11(6):484-490
    Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
    Sensitive skin is a frequently mentioned cosmetic complaint. Addition of a biomimetic of neuromediator has recently appeared as a promising new way to cure skin care product problems. This study was aimed to assess the inhibitory effect of a biomimetic lipopeptide derived from proopiomelanocortin (bPOMC) on capsaicin-induced sensory irritation in human volunteers and also to compare its protective effect with that of the well-known anti irritant strontium chloride. Read More

    Patch Test Series for Allergic Perineal Dermatitis in the Diapered Infant.
    Dermatitis 2017 Jan/Feb;28(1):70-75
    From the *Section of Pediatric Dermatology, Children's Hospital of Philadelphia, PA; and †Department of Dermatology, University of Pennsylvania, Philadelphia.
    Background: Allergic perineal dermatitis (PD) due to diaper wipes, topical medicaments, or diapers has been reported. Although patch testing is the criterion standard for detection of allergic contact dermatitis in children, this is limited by body surface area, decreased tolerance of the patch testing procedure, and increased false-positive rates due to irritant reactions. Therefore, a targeted patch testing series is necessary to better screen diapered infants for possible allergic PD. Read More

    A new treatment regimen with permethrin in scabies.
    G Ital Dermatol Venereol 2016 Dec 16. Epub 2016 Dec 16.
    Postgraduate School of Dermatology and Venereology, University of Milan, Milan, Italy.
    Background: Topical permethrin, applied once daily, is considered as the most effective treatment in scabies.

    Methods: Eighty-nine adult immunocompetent patients with scabies were treated with 5% permethrin cream: 42 patients were treated with a single application/day (group I); 47 patients were treated with one application/day for two consecutive days (group II). Clinical diagnosis of scabies was confirmed by microscopical examinations. Read More

    Skin targeting of resveratrol utilizing solid lipid nanoparticle-engrossed gel for chemically induced irritant contact dermatitis.
    Drug Deliv Transl Res 2017 Feb;7(1):37-52
    Sinhgad College of Pharmacy, Vadgaon(Bk.), Pune S. No 44/1, Vadgaon (Bk), Off Sinhgad Road, Pune, MS, 411041, India.
    Irritant contact dermatitis (ICD) is a chronic and relapsing skin disease with severe eczematous lesions. Despite its growing prevalence, therapeutic treatments remain limited. Long-term topical corticosteroid treatment can induce skin atrophy, hypopigmentation, and increase in transepidermal water loss. Read More

    Acral manifestations of contact dermatitis.
    Clin Dermatol 2017 Jan - Feb;35(1):9-18. Epub 2016 Sep 10.
    Section of Dermatology, The University of Chicago Pritzker School of Medicine, Chicago, IL. Electronic address:
    Contact dermatitis is a broad term that encompasses both nonimmunologic irritant contact dermatitis (ICD) and immunologically mediated allergic contact dermatitis (ACD). Both ICD and ACD can negatively affect a patient's quality of life and are a source of exorbitant medical and societal costs. Avoidance of inciting irritants and/or allergens and liberal use of emollients or humectants are the cornerstone of therapy. Read More

    Review of Medicinal Remedies on Hand Eczema Based on Iranian Traditional Medicine: A Narrative Review Article.
    Iran J Public Health 2016 Aug;45(8):986-996
    Dept. of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Hand Eczema (HE) is a dermatological disorder with frequent relapses and multiple causes such as atopic, allergic and irritant contact dermatitis. The management is complex because of the wide range of different pathogenesis. Efficacy of some of available treatments is not well established and it can affect patients' quality of life significantly. Read More

    [Main Causes of Occupational Allergic Contact Dermatitis: A Three Year Study in the Center of Portugal].
    Acta Med Port 2016 Aug 31;29(7-8):449-455. Epub 2016 Aug 31.
    Serviço de Dermatologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal. Clinica de Dermatologia. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.
    Introduction: Allergic contact dermatitis, along with irritant contact dermatitis and immediate contact reactions, contact urticarial, are the most frequent dermatological occupational disease, but seldom reported to the National authorities.

    Material And Methods: We performed a 3-year retrospective study at the allergology section in the Dermatology Clinic of the University Hospital of Coimbra to evaluate the main occupations diagnosed as occupational allergic contact dermatitis, most common allergens and the effect of the modification of the work station in the evolution of the disease.

    Results: During 2012 - 2014 among the 941 patch tested patients, 77 (8. Read More

    Recent Advances in Pharmacotherapeutic Paradigm of Mild to Recalcitrant Atopic Dermatitis.
    Crit Rev Ther Drug Carrier Syst 2016 ;33(3):213-263
    Department of Pharmacology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia.
    Atopic dermatitis (AD) is a common, chronic skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin E (IgE), T lymphocytes, and mast cells. The key factors responsible for the pathophysiology of this disease are immunological disorders and defects in epidermal barrier properties. Pruritus, intense itching, psychological stress, deprived physical and mental performance, and sleep disturbance are the hallmark features of this dermatological disorder. Read More

    Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC(*) prospective study.
    Contact Dermatitis 2017 Feb 29;76(2):74-80. Epub 2016 Nov 29.
    Department of Dermatology, Hospital del Mar, Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona (UAB), 08003 Barcelona, Spain.
    Background: Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens.

    Objectives: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients. Read More

    Allergic Contact Dermatitis.
    Immunol Allergy Clin North Am 2017 Feb;37(1):141-152
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland. Electronic address:
    Allergic contact dermatitis (ACD) is a common skin disease caused by a T cell-mediated immune reaction to usually innocuous allergens. ACD can have grave medical and socioeconomic consequences. ACD and irritant contact dermatitis often occur together. Read More

    Clinical and Epidemiological Features of Paederus Dermatitis Among Nut Farm Workers in Turkey.
    Am J Trop Med Hyg 2017 Feb 22;96(2):483-487. Epub 2016 Nov 22.
    Department of Medical Microbiology, Giresun University Medicine Faculty, Giresun, Turkey.
    Paederus dermatitis is an acute irritant dermatitis resulting from contact with the hemolymph of Paederus beetles. This dermatitis mimics other infectious skin disorders, often resulting in diagnostic dilemmas. This study of 46 patients was conducted to increase awareness about Paederus dermatitis. Read More

    Acquired Bilateral Longitudinal True Leukonychia in a 35-year-old Woman.
    Int J Prev Med 2016 26;7:118. Epub 2016 Oct 26.
    Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Acquired bilateral longitudinal true leukonychia is a rare disorder. We present a case of a 35-year-old healthy woman presented with this unusual and rare manifestation. She mentioned a history of unprotected exposure to detergents and bleaching chemical agents. Read More

    Tight junctions in skin inflammation.
    Pflugers Arch 2017 Jan 16;469(1):3-14. Epub 2016 Nov 16.
    Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
    Inflammation of the skin is found after various external stimuli, e.g., UV radiation, allergen uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always well-defined, stimuli, e. Read More

    Contact dermatitis and interferon-γ dependent chemokines.
    Clin Ter 2016 Sep-Oct;167(5):e112-e116
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
    Inflammation of the skin is the pathological base of contact dermatitis (CD), and cytokines are very important in its pathogenesis. Recently it has been shown that interferon (IFN)-γ, and the IFN-γ dependent chemokines, monokine induced by IFN-γ (MIG), IFN-γ-induced protein 10 (IP-10), and IFN-inducible T cell alpha chemoattractant (I-TAC), play an important role in CD. Allergic CD (ACD) is a T-cell-mediated disease in which expression of a distinct repertoire of chemokines results in the recruitment of effector T cells into the skin. Read More

    Proteomics analysis of dendritic cell activation by contact allergens reveals possible biomarkers regulated by Nrf2.
    Toxicol Appl Pharmacol 2016 Dec 3;313:170-179. Epub 2016 Nov 3.
    German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany.
    Allergic contact dermatitis is a widespread disease with high clinical relevance affecting approximately 20% of the general population. Typically, contact allergens are low molecular weight electrophilic compounds which can activate the Keap1/Nrf2 pathway. We performed a proteomics study to reveal possible biomarkers for dendritic cell (DC) activation by contact allergens and to further elucidate the role of Keap1/Nrf2 signaling in this process. Read More

    In vivo skin penetration of macromolecules in irritant contact dermatitis.
    Int J Pharm 2016 Dec 19;515(1-2):384-389. Epub 2016 Oct 19.
    Institute of Pharmaceutical Technology, Pharmacy institutes, University of Bonn, Bonn, Germany; FDE (EA4267), university of Bourgogne Franche-Comté, Besançon, France.
    Recently, a selective preferential accumulation of polymeric nanoparticles (in the size range around 100nm) has been observed in the follicular system of dermatitis skin. The present investigation aimed at clearly investigating the effect of irritant contact dermatitis on the barrier permeability for colloidal systems below this size range, namely quantum dots and hydrophilic macromolecules. Irritant dermatitis was induced in mice and the penetrability of quantum dots (5nm) and hydrophilic dextran molecules has been tracked in both healthy and inflamed skin using confocal laser scanning microscopy. Read More

    [Epidermal barrier disorders in dermatoses].
    Hautarzt 2016 Nov;67(11):907-921
    Klinik für Dermatologie, Allergologie und Venerologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 7, 24105, Kiel, Deutschland.
    The permeability barrier plays an important role in numerous skin diseases. Particularly well known is the importance of this barrier in eczema. In irritative-toxic contact dermatitis, the first step in the pathogenesis is the disturbance of the permeability barrier by irritative-toxic noxious substances. Read More

    The Scourge of the Spurge Family-An Imitator of Rhus Dermatitis.
    Dermatitis 2016 Nov/Dec;27(6):372-381
    From the *University at Buffalo School of Medicine, New York, NY; †The University of Utah Department of Dermatology, Salt Lake City; and ‡Veterans Administration Hospital, Salt Lake City, UT.
    The Euphorbiaceae family (commonly known as "spurge") is a large, diverse, and widely distributed family of plants that encompass around 300 genera and more than 8000 species. Their attractiveness and hearty nature have made them popular for both indoor ornamentation and outdoor landscaping. Despite their ubiquity, the potential to cause irritant contact dermatitis (ICD) is often overlooked in favor of more notorious causes of phytodermatitis, namely, Toxicodendron species and nettles. Read More

    Occupational Contact Dermatitis in Mechanics and Repairers Referred for Patch Testing: Retrospective Analysis From the North American Contact Dermatitis Group 1998-2014.
    Dermatitis 2017 Jan/Feb;28(1):47-57
    From the *HCMC Parkside Occupational and Contact Dermatitis Clinic and Department of Dermatology, Minneapolis Veterans Affairs Medical Center; †Department of Dermatology, University of Minnesota Medical School, Minneapolis; ‡Division of Dermatology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada; §Department of Dermatology, University of California San Francisco; ∥Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; ¶Department of Dermatology, Columbia University, New York, NY; #University of Louisville, KY; **Dartmouth-Hitchcock Medical Center, Lebanon, NH; ††Department of Dermatology, Cleveland Clinic; ‡‡Department of Dermatology, University of Cincinnati, OH; §§Associates in Dermatology, Fort Myers, FL; ∥∥University of Southern California, Keck School of Medicine, Los Angeles; ¶¶Department of Dermatology, Pennsylvania State University, University Park; ##Division of Dermatology, University of Ottawa, Canada; ***Ohio State University, Columbus; and †††Department of Dermatology, Oregon Health Science University, Portland.
    Background: Contact dermatoses are common in mechanic and repair occupations.

    Objectives: This study aimed to (1) estimate the prevalence of occupationally related contact dermatitis among mechanics/repairers patch tested from 1998 to 2014 by the North American Contact Dermatitis Group, (2) characterize responsible allergens and irritants, and their sources, and (3) compare results among 3 occupational subgroups (mechanics, electrical/electronic, and other).

    Methods: A cross-sectional analysis of patients patch tested by the North American Contact Dermatitis Group between 1998 and 2014. Read More

    Rare case of type I hypersensitivity reaction to sodium hypochlorite solution in a healthcare setting.
    BMJ Case Rep 2016 Oct 21;2016. Epub 2016 Oct 21.
    Government of Singapore Ministry of Manpower, Singapore.
    Sodium hypochlorite is a clear yellowish solution with a characteristic odour of chlorine and is commonly used as a disinfectant and a bleaching agent. It is used in various healthcare settings for its fast-acting and broad-spectrum antimicrobial activity. It is a known irritant and there are some reports that it can also cause allergic contact dermatitis of type IV hypersensitivity. Read More

    Prospective multicenter survey on the clinical management of pediatric contact dermatitis.
    Minerva Pediatr 2016 Dec;68(6):412-418
    Private practitioner, Salerno, Italy -
    Background: Contact dermatitis can be defined as an inflammatory process affecting the skin surface and induced by contact with chemical, physical and/or biotic agents in the environment. It causes lesions to skin, mucosae and semi-mucosae by means of allergic and irritant pathogenic mechanisms. Among the main triggers of contact dermatitis in the pediatric age are chemical or physical agents, which cause irritant contact dermatitis (ICD), and sensitizers, which cause a tissue damage through an allergic mechanism (allergic contact dermatitis [ACD]). Read More

    Patch testing with hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) - a multicentre study of the Swedish Contact Dermatitis Research Group.
    Contact Dermatitis 2017 Jan 21;76(1):34-39. Epub 2016 Oct 21.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: In 2014, the fragrance hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) was excluded from the Swedish baseline series.

    Objectives: To study (i) whether fragrance mix (FM) II with 5% HICC detects more positive reactions than usual FM II with 2.5% HICC, and (ii) the reproducibility of patch testing with HICC. Read More

    Occupational dermatitis in hairdressers - influence of individual and environmental factors.
    Contact Dermatitis 2016 Oct 6. Epub 2016 Oct 6.
    Department of Dermatology, Bispebjerg University Hospital, Copenhagen, 2400, Denmark.
    Background: Hairdressers are at risk of developing occupational contact dermatitis because of their intense contact with wet work in combination with chemicals.

    Objectives: To perform an analysis of a cohort study of hairdressers with occupational contact dermatitis recognized in the period 2006-2011, focusing on individual and environmental factors associated with the disease.

    Methods: The study was a descriptive, register-based survey including all hairdressers with recognized occupational contact dermatitis in Denmark in the period January 2006 to September 2011. Read More

    Infant Skin Care Products: What Are the Issues?
    Adv Neonatal Care 2016 Oct;16 Suppl 5S:S3-S12
    Neonatal Clinical Nurse Specialist, UCSF Benioff Children's Hospital, Oakland, California.
    Background: Infant skin is susceptible to dryness and irritation from external factors, including topical skin care products not formulated for the infant's skin. This may increase the risk of contact dermatitis. Parents frequently express concern regarding potential harm from ingredients in skin care products and seek information. Read More

    JAK inhibitor JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation.
    J Dermatol Sci 2016 Dec 13;84(3):258-265. Epub 2016 Sep 13.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:
    Background: Using JAK inhibitors to inhibit cytokine signaling is presumed to be a possible means of treating skin inflammatory disorders such as contact dermatitis.

    Objective: To clarify the action site of JAK inhibitors in skin inflammatory disorders.

    Methods: We analyzed the mechanism of action of the JAK inhibitor JTE-052 using murine skin inflammation models, including contact hypersensitivity (CHS) and irritant contact dermatitis. Read More

    Chromate and amine contact allergies in workers manufacturing precast concrete elements.
    Contact Dermatitis 2016 Dec 23;75(6):363-369. Epub 2016 Sep 23.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, 205 02, Sweden.
    Background: Five workers from a plant manufacturing concrete wall panels and beams were referred to our department because of suspected occupational dermatitis. When patch tested, 3 workers reacted to potassium dichromate. Four workers reacted to ethylenediamine dihydrochloride, without any obvious exposure. Read More

    Could Topical Minoxidil Cause Non-Arteritic Anterior Ischemic Optic Neuropathy?
    J Clin Diagn Res 2016 Aug 1;10(8):WD01-2. Epub 2016 Aug 1.
    Consultant Ophtalmologist, Department of Ophtalmology, Karabük Education and Researh Hospital , Karabük .
    Minoxidil hair formulation is commonly used for the treatment of male or female androgenic alopecia. Minoxidil is a Health Canada and US FDA-approved medication for hair loss in men and women. The drug is marketed as 2% and 5% topical solutions. Read More

    The Association of Race/Ethnicity and Patch Test Results: North American Contact Dermatitis Group, 1998-2006.
    Dermatitis 2016 Sep-Oct;27(5):288-92
    From the Department of Dermatology, Keck School of Medicine of the University of Southern California, Los Angeles.
    Background: The North American Contact Dermatitis Group patch tests patients with suspected allergic contact dermatitis (ACD) to a broad series of screening allergens and publishes periodic reports. We have previously reported on the association of race and ethnicity with the rates of positive responses to standard patch test allergens. This report extends those observations. Read More

    Compounded Topical Analgesics for Chronic Pain.
    Dermatitis 2016 Sep-Oct;27(5):263-71
    From the *Medical College of Georgia, and †Division of Dermatology, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA.
    Analgesic medications compounded for topical use are gaining popularity for the management of chronic pain. The advantages of topical pain medications include reduction of systemic adverse effects, improved patient acceptance, few drug interactions, ease of dose determination, avoidance of first-pass metabolism, and direct access to the target site. Compounded topical medications typically use a mixture of 3 or more single medications to achieve multiple complementary effects at lower doses of each individual medication. Read More

    Granular parakeratosis induced by benzalkonium chloride exposure from laundry rinse aids.
    Australas J Dermatol 2016 Sep 19. Epub 2016 Sep 19.
    Department of Dermatology, Royal Children's Hospital, Melbourne, Victoria, Australia.
    Benzalkonium chloride is a quaternary ammonium cationic detergent present in a number of household products, which can act as a major skin irritant. We present the case of six children who developed granular parakeratosis after exposure to benzalkonium chloride in laundry rinse aids, presenting as a brightly erythematous, tender but minimally pruritic, intertriginous eruption followed by superficial desquamation. The eruptions resolved over 3-4 weeks after cessation of exposure. Read More

    Stoma care products represent a common and previously underreported source of peristomal contact dermatitis.
    Contact Dermatitis 2017 Jan 31;76(1):27-33. Epub 2016 Aug 31.
    Department of Dermatology, Weill Cornell Medical Center and New York-Presbyterian Hospital, New York, NY 10065, USA.
    Background: Peristomal dermatitis is a common complication for the >700 000 patients in the United States with an ostomy. The role of stoma skin care products in peristomal dermatitis is poorly understood.

    Objective: To evaluate stoma skin care products as a cause of peristomal dermatitis. Read More

    Differences in contents of organochlorine impurities do not influence responses to patch testing with Majantol®.
    Contact Dermatitis 2017 Jan 24;76(1):11-18. Epub 2016 Aug 24.
    Information Network of Departments of Dermatology (IVDK), 37075, Göttingen, Germany.
    Background: Majantol® [2,2-dimethyl-3-(3-methylphenyl)propan-1-ol; CAS no. 103694-68-4] has been identified as a contact allergen in humans, despite negative animal tests. Hence impurities, specifically organochlorines, in Majantol® might have been the reason for positive patch test reactions in the past. Read More

    The three moments of skin cream application: an evidence-based proposal for use of skin creams in the prevention of irritant contact dermatitis in the workplace.
    J Eur Acad Dermatol Venereol 2017 Jan 22;31(1):53-64. Epub 2016 Aug 22.
    Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
    Contact dermatitis is one of the most common occupational diseases, with serious impact on quality of life, lost days at work and a condition that may be chronically relapsing. Regular prophylactic skin cream application is widely acknowledged to be an effective prevention strategy against occupational contact dermatitis; however, compliance rates remain low. To present a simple programme for skin cream application in the workplace with focus on implementation to drive down the rate of occupational irritant contact dermatitis, an expert panel of eight international dermatologists combined personal experience with extensive literature review. Read More

    Occupational contact sensitization in female geriatric nurses: Data of the Information Network of Departments of Dermatology (IVDK) 2005-2014.
    J Eur Acad Dermatol Venereol 2016 Aug 12. Epub 2016 Aug 12.
    Information Network of Departments of Dermatology, University of Göttingen, Göttingen, Germany.
    Background: Geriatric nurses (GN) have a high risk of occupational contact dermatitis (OCD), with chronic irritant contact dermatitis predominating. However, allergic contact dermatitis is an important issue as well. Little is known whether the relevant occupational allergen spectrum reported in the 1990s, including fragrances, preservatives, rubber chemicals and ingredients of surface disinfectants to be the most common sensitizers in GN, is still valid. Read More

    Ten pearls every dermatologist should know about the appropriate use of relaxers.
    J Cosmet Dermatol 2016 Jul 29. Epub 2016 Jul 29.
    Division of Dermatology, Medical College of Georgia, Augusta University, formerly Georgia Regents University, Augusta, GA, USA.
    Chemical relaxers are products marketed to straighten the hair and have been principally used by African Americans since the early twentieth century. They contain alkaline agents that break and reform hydrogen and disulfide bonds, leaving hair permanently straightened. Relaxers cause loss of tensile strength and increased fragility of the hair shaft that lead to increased risk of hair breakage and thinning. Read More

    [The functional role of zinc in skin diseases].
    Nihon Rinsho 2016 Jul;74(7):1144-9
    Abstract Acrodermatitis enteropathica(AE) is caused by inherited or acquired zinc deficiency. Cutaneous clinical manifestations observed in AE include characteristic dermatitis on acral, periorificial and anogenital areas through an unknown mechanism. Recently, we found that mice fed a zinc-deficient diet develop a severe irritant contact dermatitis that has the histological features of the skin inflammation seen in AE patients. Read More

    Assessment of the in vitro dermal irritation potential of cerium, silver, and titanium nanoparticles in a human skin equivalent model.
    Cutan Ocul Toxicol 2016 Aug 8:1-7. Epub 2016 Aug 8.
    b U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory , Research Triangle Park , NC , USA.
    Metal nanoparticles can potentially contact human skin during their manufacture and use in commercial products. This study examined the potential of metal nanoparticles to elicit irritant contact dermatitis in a human skin equivalent model (HSEM) derived from keratinocytes. Ag (10-100 nm), TiO2 (22-214 nm), and CeO2 (15-40 nm) nanoparticles were studied. Read More

    Occupational skin disease among Australian healthcare workers: a retrospective analysis from an occupational dermatology clinic, 1993-2014.
    Contact Dermatitis 2016 Oct 20;75(4):213-22. Epub 2016 Jul 20.
    Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation Inc., Carlton, Victoria, 3053, Australia.
    Background: Healthcare workers (HCWs) are at risk of developing occupational skin disease (OSD).

    Objectives: To ascertain the causes of OSD in Australian HCWs in a tertiary referral clinic.

    Methods: A retrospective review was performed of patients assessed at the Occupational Dermatology Clinic in Melbourne from 1993 to 2014. Read More

    In vivo assessment of cytological changes by means of reflectance confocal microscopy - demonstration of the effect of topical vitamin E on skin irritation caused by sodium lauryl sulfate.
    Contact Dermatitis 2016 Jul 15. Epub 2016 Jul 15.
    Department of Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, 42100, Reggio Emilia, Italy.
    Background: Irritant contact dermatitis is caused by skin barrier damage. Vitamin E is an antioxidant that is commonly used in cosmetics to prevent photo-damage.

    Objectives: To show the usefulness of reflectance confocal microscopy in the assessment of irritant skin damage caused by sodium lauryl sulfate (SLS) and of the protective action of vitamin E applied prior to skin irritation. Read More

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