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    1 OF 301

    Polymorphic light eruption and IL-1 family members: any difference with allergic contact dermatitis?
    Photochem Photobiol Sci 2017 Aug 16. Epub 2017 Aug 16.
    Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy.
    Polymorphic light eruption (PLE) is described as a delayed-type hypersensitivity reaction (DTHR) toward a de novo light-induced antigen, yet to be identified. In effect, the inflammatory pathways of PLE and allergic contact dermatitis (ACD) share common patterns in terms of the mediators involved from the innate and adaptive immune system participating in the DTHR. As we have previously highlighted the role of interleukin (IL)-1 family members in ACD, we hypothesised that the same mediators could have similar functions in PLE. Read More

    Characterizing the Diagnosis and Treatment of Allergic Contact Dermatitis to 2-Octyl Cyanoacrylate Used for Skin Closure in Elective Orthopedic Surgery.
    J Arthroplasty 2017 Jul 18. Epub 2017 Jul 18.
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: While studies have shown that postoperative wound complications can predispose to deep infection following orthopedic surgery, the best form of skin closure has not been elucidated. Furthermore, the unique risks and benefits of each type of wound closure have not been studied. The goal of this study is to present the diagnosis and treatment of patients with allergic contact dermatitis (ACD) from 2-octyl cyanoacrylate, a skin adhesive commonly used in wound closure. Read More

    Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch.
    J Allergy Clin Immunol 2017 Aug 5. Epub 2017 Aug 5.
    Center for the Study of Itch, Department of Anesthesiology, Washington University School of Medicine, St Louis, Mo. Electronic address:
    Background: Chronic itch is a highly debilitating symptom that underlies many medical disorders with no universally effective treatments. Although unique neuronal signaling cascades in the sensory ganglia and spinal cord have been shown to critically promote the pathogenesis of chronic itch, the role of skin-associated cells remains poorly understood.

    Objective: We sought to examine the cutaneous mechanisms underlying transient receptor potential vanilloid 4 (TRPV4)-mediated allergic and nonallergic chronic itch. Read More

    Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor.
    Contact Dermatitis 2017 Aug 14. Epub 2017 Aug 14.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks.

    Objectives: To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen.

    Patients And Methods: Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre. Read More

    Occupational contact urticaria and protein contact dermatitis: causes and concomitant airway diseases.
    Contact Dermatitis 2017 Aug 10. Epub 2017 Aug 10.
    Occupational Medicine, Finnish Institute of Occupational Health, 00251, Helsinki, Finland.
    Background: Contact urticaria (CU) and protein contact dermatitis (PCD) are mainly induced by an immediate, IgE-mediated immunological mechanism. Immediate sensitization is also linked to asthma and/or allergic rhinitis.

    Objectives: To report causes of work-induced CU and PCD, and to evaluate the occurrence of concomitant airway diseases. Read More

    Are metals involved in tattoo-related hypersensitivity reactions? A case report.
    Contact Dermatitis 2017 Aug 9. Epub 2017 Aug 9.
    Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany.
    Background: Allergic reactions to tattoos are not uncommon. However, identification of the culprit allergen(s) remains challenging.

    Objectives: We present a patient with papulo-nodular infiltration of 20-year-old tattoos associated with systemic symptoms that disappeared within a week after surgical removal of metal osteosynthesis implants from his spine. Read More

    An observational study on the effects of aviation turbine fuel and lubricants on the skin of Indian Air Force ground crew in flying stations.
    Med J Armed Forces India 2017 Jul 11;73(3):294-298. Epub 2016 Aug 11.
    Assistant Surgeon, O/o Deputy Director Medical Services (Leprosy), Collectorate, Salem District, Tamil Nadu 636001, India.
    Background: Ground crew of the Air Force routinely handle aviation turbine fuel (ATF) and lubricants and a need was felt to study the adverse effects of these substances on their skin so that remedial measures could be taken to prevent these adverse effects.

    Methods: A multi-centric, cross-sectional, observational study was performed at three Air Force flying stations. 109 ground crew members of the Indian Air Force (IAF) who were in direct contact with ATF and lubricants were screened for dermatological manifestations on exposed areas. Read More

    Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation.
    Sci Immunol 2016 Sep;1(3):eaaf8665
    Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany.
    Skin-migratory dendritic cells (migDCs) are pivotal antigen-presenting cells that continuously transport antigens to draining lymph nodes and regulate immune responses. However, identification of migDCs is complicated by the lack of distinguishing markers, and it remains unclear which molecules determine their migratory capacity during inflammation. We show that, in the skin, the neuronal plasticity molecule activity-regulated cytoskeleton-associated protein/activity-regulated gene 3. Read More

    Skin diseases of the vulva: eczematous diseases and contact urticaria.
    J Obstet Gynaecol 2017 Aug 7:1-6. Epub 2017 Aug 7.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    Skin diseases in the vulvar area include a variety of disorders many of which have a chronic course with significant morbidity. It is important to be aware of the symptoms, signs and diagnostic tools in order to optimise treatment. Herein, the most common eczematous diseases of the vulvar area, i. Read More

    Atopic and Contact Dermatitis of the Vulva.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):371-378
    Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:
    Pruritus, or itch, is a common vulvar complaint that is often treated empirically as a yeast infection; however, yeast infections are just one of the many conditions that can cause vulvar itch. Ignoring other conditions can prolong pruritus unnecessarily. Atopic dermatitis, irritant contact dermatitis, and allergic contact dermatitis are extremely common noninfectious causes of vulvar itch that are often underdiagnosed by nondermatologists. Read More

    Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes: in search of the culprit allergen.
    Contact Dermatitis 2017 Aug 4. Epub 2017 Aug 4.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: During rubber vulcanization, new compounds can be formed.

    Objectives: To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS).

    Methods: A female presented with eczema on her feet after wearing Sperry Top Sider® canvas sneakers. Read More

    Suppressive Effects of Mesenchymal Stem Cells in Adipose Tissue on Allergic Contact Dermatitis.
    Ann Dermatol 2017 Aug 21;29(4):391-399. Epub 2017 Jun 21.
    Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
    Background: Allergic contact dermatitis (ACD), which is accelerated by interferon (IFN)-γ and suppressed by interleukin (IL)-10 as regulators, is generally self-limited after removal of the contact allergen. Adipose tissue-derived multipotent mesenchymal stem cells (ASCs) potentially exert immunomodulatory effects. Considering that subcutaneous adipose tissue is located close to the site of ACD and includes mesenchymal stem cells (MSCs), the MSCs in adipose tissue could contribute to the self-limiting course of ACD. Read More

    Patterns of concomitant allergic reactions in patients suggest cross-sensitization between octylisothiazolinone and methylisothiazolinone.
    Contact Dermatitis 2017 Jul 28. Epub 2017 Jul 28.
    Occupational Medicine, Finnish Institute of Occupational Health (FIOH), 00250 Helsinki, Finland.
    Background: Recent animal tests have indicated cross-reactivity between methylisothiazolinone (MI), octylisothiazolinone (OIT), and benzisothiazolinone (BIT).

    Objectives: To retrospectively analyse concomitant reactions to different isothiazolinones in patients in an occupational dermatology clinic during the ongoing MI contact allergy epidemic.

    Methods: We searched patch test files (January 2012 to February 2017) for patients with allergic reactions to OIT, BIT, and MI, and analysed their patch test results, occupations, exposure, and diagnoses. Read More

    Accelerator-free gloves as alternatives in cases of glove allergy in healthcare workers.
    Contact Dermatitis 2017 Jul 27. Epub 2017 Jul 27.
    Department of Occupational and Environmental Diseases, University Hospital of Centre of Paris, Hotel-Dieu Hospital, AP-HP, 75004 Paris, France.
    Background: Accelerators in rubber gloves constitute an important group of contact allergens, particularly in healthcare workers.

    Objectives: To assess the efficacy of accelerator-free medical gloves in the secondary prevention of allergic contact dermatitis caused by rubber accelerators in healthcare workers.

    Methods: Nine healthcare workers with hand eczema were advised to use accelerator-free rubber gloves after a diagnosis of allergic contact dermatitis caused by rubber accelerators. Read More

    Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.
    J Immunol 2017 Jul 26. Epub 2017 Jul 26.
    Department of Dermatology, Duke University, Durham, NC 27710;
    The innate immune components that modulate allergic contact hypersensitivity (CHS) responses are poorly defined. Using human skin from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and inducible NO synthase (iNOS) dynamic in monocytes/macrophages (mono/MΦ), which renders those cells ineffectual in suppressing skin inflammation. Mice lacking Arg1 in MΦ develop increased CHS characterized by elevated ear thickening, mono/MΦ-dominated dermal inflammation, and increased iNOS and IL-6 expression compared with control mice. Read More

    Improved transdermal delivery of morin efficiently inhibits allergic contact dermatitis.
    Int J Pharm 2017 Jul 21;530(1-2):145-154. Epub 2017 Jul 21.
    Key Laboratory of Drug Targeting and Novel Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, PR China. Electronic address:
    The skin is an important site for local or systemic application of drugs. However, most of the drugs have poor permeability through the skin's outermost layer, stratum corneum. The aim of this study was to develop a method to enable transdermal delivery of morin (3, 5, 7, 2, 4-pentahydroxyflavone), which is a poorly water-soluble drug with anti-inflammatory properties obtained from natural products. Read More

    Dermatitis of the Foot: Epidemiologic and Clinical Features in 389 Children.
    Pediatr Dermatol 2017 Jul 21. Epub 2017 Jul 21.
    Dermatology Department, Valencia University General Hospital, Valencia, Spain.
    Background/objectives: Footwear dermatitis is a form of contact dermatitis resulting from exposure to shoes. There have been only small studies regarding foot contact dermatitis in children. The present study was undertaken to define the prevalence and epidemiologic and clinical features of shoe dermatitis in children. Read More

    Prevalence of nickel allergy in Europe following the EU Nickel Directive - a review.
    Contact Dermatitis 2017 Jul 21. Epub 2017 Jul 21.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Nickel contact allergy remains a problem in EU countries, despite the EU Nickel Directive. To study the prevalence of nickel allergy in EU countries following the implementation of the EU Nickel Directive, we performed a systematic search in PubMed for studies that examined the prevalence of nickel allergy in EU countries published during 2005-2016. We identified 46 studies: 10 in the general population and 36 in patch tested dermatitis patients. Read More

    Allergic Contact Dermatitis From Methylisothiazolinone in Residential Wall Paint.
    Dermatitis 2017 Jul/Aug;28(4):284-287
    From the *Department of Dermatology, University of Minnesota Medical School; †HCMC Parkside Occupational and Contact Dermatitis Clinic; and ‡Minneapolis Veterans Affairs Medical Center, Department of Dermatology, Minneapolis, MN; and §Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
    A 33-year-old woman presented to our clinic for suspected photoallergic contact dermatitis with a recent episode of severe, vesicular dermatitis involving exposed skin and correlating with relocation to a new home. Biopsy results showed spongiotic and lichenoid dermatitis with eosinophils. Patch test results showed a very strong (+++) reaction to methylisothiazolinone (MI), mild (+) reaction to MI/methylchloroisothiazolinone, and no reaction to benzisothiazolinone. Read More

    Contact Sensitization to Allergens in Nail Cosmetics.
    Dermatitis 2017 Jul/Aug;28(4):231-240
    From the *Icahn School of Medicine at Mount Sinai; and †Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.
    Ingredients found in the nail cosmetic industry, including but not limited to methacrylate and acrylate monomers, formaldehyde, and toluene sulfonamide-formaldehyde resin, can incite allergic contact dermatitis. An eczematous outbreak presents on areas surrounding the nail plate and may spread through contact transfer of the allergen, commonly to the face and neck. Even components that were originally deemed nonsensitizing, such as the ubiquitous cyanoacrylate adhesive family, have been found to be allergenic. Read More

    Contact dermatitis considerations in atopic dermatitis.
    Clin Dermatol 2017 Jul - Aug;35(4):367-374. Epub 2017 Apr 22.
    Department of Dermatology, Loma Linda University, Loma Linda, CA. Electronic address:
    Complex immunologic pathways, influenced by both genetic and environment triggers, contribute to the development of atopic dermatitis and allergic contact dermatitis. Suppressing mechanisms between the Th1-driven allergic contact dermatitis and the Th2-driven atopic dermatitis conditions were thought to reduce the simultaneous expression of both; however, recent evidence indicates that pediatric patients with atopic dermatitis are likely to develop clinically relevant positive patch tests and more likely to react to specific allergens, such as lanolin. We review the potential role of skin barrier defects, such as filaggrin mutations and impaired barrier function, including aberrancies in epidermal pH buffering capabilities, which may promote bacterial biofilms and create an environment favoring sensitization. Read More

    In vitro effects of nickel on healthy non allergic peripheral blood mononuclear cells. The role of red grape polyphenols.
    Endocr Metab Immune Disord Drug Targets 2017 Jul 13. Epub 2017 Jul 13.
    Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, School of Medicine, Bari. Italy.
    Background: Nickel (Ni) is widely distributed in the environment and continuous exposure to this metal may lead to pathological manifestations, such as the human allergic contact dermatitis.

    Methods: The in vitro effects of Ni on human healthy non allergic peripheral blood mononuclear cells (PBMCs) in the absence or presence of red grape polyphenols have been evaluated. In the culture supernatants, levels of cytokines have been determined by ELISA, while nitric oxide (NO) concentration has been evaluated by a colorimetric procedure. Read More

    Identification of unique proteomic signatures in allergic and non-allergic skin disease.
    Clin Exp Allergy 2017 Jul 13. Epub 2017 Jul 13.
    MedImmune, LLC, Gaithersburg, MD, USA.
    Background: Atopic dermatitis (AD), psoriasis (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and systemic inflammation, with unique epidermal signatures and common inflammatory pathways identified by transcriptomic profiling. This study profiled proteomic signatures in serum from subjects with AD, PS, and CD compared with healthy controls (HC).

    Objective: Identify unique proteomic signatures to distinguish between inflammatory diseases with similar epidermal disruption and overlapping epithelial inflammation. Read More

    Tlx3 Function in the Dorsal Root Ganglion is Pivotal to Itch and Pain Sensations.
    Front Mol Neurosci 2017 28;10:205. Epub 2017 Jun 28.
    Beijing Institute of BiotechnologyBeijing, China.
    Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Here, our RNAseq and in situ hybridization data show that the transcription factor Tlx3 is required for the expression of a majority of itch-related molecules in the dorsal root ganglion (DRG). Read More

    Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata.
    Open Access Maced J Med Sci 2017 Jun 11;5(3):305-309. Epub 2017 Jun 11.
    Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.

    Aim: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals. Read More

    Elevation of Circulating Th17/Th22 Cells Exposed to Low-Level Formaldehyde and Its Relevance to Formaldehyde-Induced Occupational Allergic Contact Dermatitis.
    J Occup Environ Med 2017 Jul 10. Epub 2017 Jul 10.
    Department of Prevention and Healthcare, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China (Dr Mai, Su); Department of General Surgery, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China (Mr Liu); Department of Laboratory Science, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China (Ms Zhou); and Department of Dermatology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China (Mr Wen, Mr Lu).
    Objectives: The aim of this study was to investigate the effects of formaldehyde exposure on Th17 and Th22 cells and its relevance to human occupational allergic contact dermatitis (OACD).

    Methods: Circulating IL17-/IL22-secreting cells and serum IL17/IL22 levels in formaldehyde-exposed workers at Occupational Exposure Limit and nonexposed controls were assessed.

    Results: The IL17 and IL22 cell population were detected in both CD3CD8 and CD3CD8 cells. Read More

    Variation in aluminium patch test reactivity over time.
    Contact Dermatitis 2017 Jul 11. Epub 2017 Jul 11.
    Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 20502, Malmö, Sweden.
    Background: Contact allergy to aluminium has been reported more frequently in recent years. It has been pointed out that positive patch test reactions to aluminium may not be reproducible on retesting.

    Objectives: To investigate possible variations in patch test reactivity to aluminium over time. Read More

    [Basis for the treatment of eczematous diseases in otorhinolaryngology].
    HNO 2017 Jul 10. Epub 2017 Jul 10.
    Zentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland.
    According to Coombs and Gell, cell-mediated immune responses belong to type IV reactions and are borne mainly by T lymphocytes. The eliciting allergens are usually so-called haptens. Haptens are substances which develop to whole antigens only by binding to protein carriers. Read More

    In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis.
    J Control Release 2017 Sep 8;261:223-233. Epub 2017 Jul 8.
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, United States; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261, United States; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address:
    Allergic contact dermatitis (ACD) is a common T-cell mediated inflammatory skin condition, characterized by an intensely pruritic rash at the site of contact with allergens like poison ivy or nickel. Current clinical treatments use topical corticosteroids, which broadly and transiently suppress inflammation and symptoms of ACD, but fail to address the underlying immune dysfunction. Here, we present an alternative therapeutic approach that teaches the immune system to tolerate contact allergens by expanding populations of naturally suppressive allergen-specific regulatory T cells (Tregs). Read More

    Site-specific regulation of oral mucosa-recruiting CD8(+) T cells in a mouse contact allergy model.
    Biochem Biophys Res Commun 2017 Sep 4;490(4):1294-1300. Epub 2017 Jul 4.
    Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. Electronic address:
    Contact allergy is a T cell-mediated, delayed-type hypersensitivity generated by contact exposure of an allergen to the skin and mucosal surface. The clinical manifestations of allergic responses between the skin and oral mucosa vary and the differences in immunopathology have not been clarified. We generated hapten-induced contact hypersensitivity (CH) of the buccal mucosa (BM) in parallel studies with ear skin (ES) CH, and observed several characteristic findings of BM CH. Read More

    Simultaneous patch testing with fragrance mix I, fragrance mix II and their ingredients in southern Sweden between 2009 and 2015.
    Contact Dermatitis 2017 Jul 7. Epub 2017 Jul 7.
    Lund University, Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy.

    Objectives: To investigate the frequency of allergic reactions to FM I, FM II and their ingredients in consecutively patch tested patients.

    Materials And Methods: A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed. Read More

    Allergic contact dermatitis to acrylates.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2):529-534
    Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, Bari, Italy.
    Acrylates and methacrylates are a large group of chemically reactive monomers that are polymerized into acrylic plastics. These have very broad applications in glues, coatings and various plastic materials. Allergic contact dermatitis (ACD) caused by acrylates can be occupational, mainly in dentistry workers during the manufacturing and implantation of dental prosthesis, and in nail technicians during the sculpturing and application of artificial nails. Read More

    Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens.
    Contact Dermatitis 2017 Sep 5;77(3):133-142. Epub 2017 Jul 5.
    Department of Dermatology-Allergy, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900, Hellerup, Denmark.
    Allergic contact dermatitis is one of the most frequent forms of skin inflammation. Very often, we are exposed to mixtures of allergens with varying potencies, doses/areas, and exposure times. Therefore, improved knowledge about immune responses to combinations of contact allergens is highly relevant. Read More

    Allergic contact dermatitis caused by a new temporary blue-black tattoo dye - sensitization to genipin from jagua (Genipa americana L.) fruit extract.
    Contact Dermatitis 2017 Jul 4. Epub 2017 Jul 4.
    Kantonales Laboratorium Basel-Stadt, 4056 Basel, Switzerland.
    Background: Temporary tattoos made with an extract of the jagua fruit (Genipa americana L.) are becoming increasingly popular. It is claimed that it is 'dermatologically tested' and does not contain p-phenylenediamine. Read More

    A population-based study of self-reported skin exposures and symptoms in relation to contact allergy in adolescents.
    Contact Dermatitis 2017 Jul 4. Epub 2017 Jul 4.
    Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.
    Background: Knowledge about the relations between skin exposures, skin symptoms and contact allergy in adolescents is limited.

    Objectives: To explore self-reported skin exposures and skin symptoms in girls and boys, and to assess the associations between exposures, symptoms and contact allergy at age 16 years.

    Participants And Methods: In all, 3115 adolescents from the population-based BAMSE birth cohort answered a questionnaire at age 16 concerning various skin exposures and related skin symptoms. Read More

    Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy.
    Int J Mol Sci 2017 Jun 25;18(7). Epub 2017 Jun 25.
    Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan.
    Palladium is frequently used in dental materials, and sometimes causes metal allergy. It has been suggested that the immune response by palladium-specific T cells may be responsible for the pathogenesis of delayed-type hypersensitivity in study of palladium allergic model mice. In the clinical setting, glucocorticoids and antihistamine drugs are commonly used for treatment of contact dermatitis. Read More

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