15,851 results match your criteria Contact Dermatitis Allergic


N,N-dimethylacrylamide - a new sensitizer in the FreeStyle Libre glucose sensor.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Lund University, Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö, Sweden.

Background: Isobornyl acrylate (IBOA) has recently been identified as one sensitizer in the FreeStyle Libre glucose sensor. Analyses by gas chromatography-mass spectrometry (GC-MS) have indicated the presence of N,N-dimethylacrylamide (DMAA) in the sensor.

Material And Methods: Seven patients were referred for patch testing after developing skin reactions when using FreeStyle Libre. Read More

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http://dx.doi.org/10.1111/cod.13243DOI Listing
February 2019

Hand eczema among Dutch beekeepers - a cross-sectional study.

J Dtsch Dermatol Ges 2019 02;17(2):158-166

University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.

Background And Objectives: Studies of beekeepers have mostly focused on contact allergy to propolis. The overall prevalence of hand eczema (HE) in beekeepers has not been studied. Our objectives were to gain insight into the prevalence of HE in the Dutch beekeeper population; to define the impact of beekeeping activities on HE and vice versa; and to determine associated factors. Read More

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http://dx.doi.org/10.1111/ddg.13754DOI Listing
February 2019

Allergic contact dermatitis caused by isobornyl acrylate when using the FreeStyle Libre.

J Diabetes Investig 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, Nihon University Hospital, Tokyo, Japan.

We present the case of an 8-year old girl with type 1 diabetes, who developed severe allergic contact dermatitis by using FreeStyle Libre. A patch test was performed by a piece of the adhesive part of the sensor of the FreeStyle Libre, and subsequently by using the potential contact allergens in the sensor, isobornyl acrylate (IBOA). She reacted positively to the adhesive part of the sensor, and also reacted positively to IBOA with three different concentrations, 0. Read More

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http://dx.doi.org/10.1111/jdi.13023DOI Listing
February 2019

IL-24 contributes to skin inflammation in Para-Phenylenediamine-induced contact hypersensitivity.

Sci Rep 2019 Feb 12;9(1):1852. Epub 2019 Feb 12.

de Duve Institute, Université catholique de Louvain, Brussels, Belgium.

Para-Phenylenediamine (PPD) is an aromatic amine used in hair dyes and in temporary black henna tattoos, which is a frequent cause of allergic contact dermatitis (ACD). ACD is a skin inflammatory reaction characterized by modifications such as spongiosis, exocytosis and acanthosis. The aim of this study is to characterize the expression and the role of IL-20-related cytokines, including IL-19, IL-20, IL-22 and IL-24, in ACD. Read More

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http://dx.doi.org/10.1038/s41598-018-38156-4DOI Listing
February 2019

Contact allergy in children with atopic dermatitis: a retrospective study.

Endocr Metab Immune Disord Drug Targets 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, IT-70124 Bari. Italy.

Backgound: The relationship between atopic dermatitis and allergic contact dermatitis is frequently debated, particularly in children. The impaired skin barrier of atopic subjects can facilitate the penetration of exogenous agents and its mutations in filaggrin gene might be implicated in an increased risk to develop contact dermatitis. Moreover, atopic children are protractedly exposed to chemical substances contained in skincare products from an early age. Read More

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http://www.eurekaselect.com/169857/article
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http://dx.doi.org/10.2174/1871530319666190211123342DOI Listing
February 2019
3 Reads

Using Patch Testing to Improve Therapeutic Outcome in the Treatment of Hand Eczema in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 23;7(2):204-207. Epub 2019 Jan 23.

University of Rome G. Marconi, Rome, Italy.

Background: Hand eczema is a common chronic and relapsing skin disease with various clinical features. Hand eczema aetiology can be allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), atopic dermatitis (AD) and unknown or combination causes. If the causative agents are not detected treatment of hand eczema will be a failure. Read More

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http://dx.doi.org/10.3889/oamjms.2019.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364736PMC
January 2019
1 Read

Bullous irritant contact dermatitis due to alcoholic extract from Juglans regia leaves.

Contact Dermatitis 2019 Feb 11. Epub 2019 Feb 11.

Section of Dermatology, Department of Medical Sciences, University of Ferrara, Italy.

Phytotherapeutic remedies can be responsible for allergic and irritant contact dermatitis and even chemical burns (1). We report a case of irritant contact dermatitis due to alcoholic extract from Juglans regia leaves. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/cod.13240DOI Listing
February 2019
1 Read

Allergic contact dermatitis to (meth)acrylates involving nail technicians and users: prognosis and differential diagnosis.

Allergy 2019 Feb 10. Epub 2019 Feb 10.

Department of Dermatology, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain Universidad de Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1111/all.13736DOI Listing
February 2019
1 Read

Pigments in American Tattoo Inks and their Propensity to Elicit Allergic Contact Dermatitis.

J Am Acad Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Park Nicollet Contact Dermatitis Clinic, Bloomington, MN; Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN.

Background: Tattoos have become increasingly common in the United States. Historically, tattoo inks were comprised of metallic pigments which had the potential to cause allergic contact dermatitis. Data have been lacking on the current use of these pigments in tattoo ink. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.01.078DOI Listing
February 2019

"Slime": A trending cause of isothiazolinone contact allergy in children.

Contact Dermatitis 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, Marmara University School of Medicine, Istanbul, Turkey.

Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI, eg Kathon CG), and MI are widely available preservatives mainly used in cosmetic and household products. Following a worldwide increase in contact allergy to MCI/MI and MI, regulatory measures have been implemented. Although a decrease in contact sensitization has been reported, MCI/MI and MI are still a frequent cause of contact dermatitis and unexpected sources of exposure may be encountered in clinical practice. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cod.13237
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http://dx.doi.org/10.1111/cod.13237DOI Listing
February 2019
4 Reads

Allergic contact dermatitis to gold weight upper-eyelid implant.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Hospital Universitario, 12 de Octubre, I+12 Research Institute Universidad Complutense, Madrid, Spain.

Gold-weights are used for the correction of lagophthalmos associated with facial nerve injury since the 1960s. Complications associated with these are rare, being more frequent those associated with incorrect size and weight of the implant or infections processes. Non-infectious persistent inflammatory reactions, suggesting type IV hypersensitivity to gold, are poorly described in the literature. Read More

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http://dx.doi.org/10.1111/jdv.15470DOI Listing
February 2019

Serum galectin-9 levels in atopic dermatitis, psoriasis and allergic contact dermatitis: A cross-sectional study.

Indian J Dermatol Venereol Leprol 2019 Mar-Apr;85(2):195-196

Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_252_18DOI Listing
February 2019

Italian guidelines in patch testing adapted from the European Society of Contact Dermatitis (ESCD).

G Ital Dermatol Venereol 2019 Feb 4. Epub 2019 Feb 4.

Dermatologic Clinic, University of Brescia, Brescia, Italy.

Patch testing is the standard procedure used to diagnose allergic contact dermatitis. It is an in vivo test, which reproduce the reaction to a contact allergen. This in vivo test aims to reproduce the elicitation phase of allergic contact dermatitis and is performed applying allergens under occlusion on the skin under standardized conditions. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06301-6DOI Listing
February 2019
1 Read

Occupational lichenoid allergic contact dermatitis caused by tin.

Contact Dermatitis 2019 Feb 3. Epub 2019 Feb 3.

Dermatology Department, Hospital de Santarém EPE, Santarém, Portugal.

Allergic reactions to tin were previously reported in the literature (1,2). True cases of allergic contact dermatitis, however, are very rare. This article is protected by copyright. Read More

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http://doi.wiley.com/10.1111/cod.13236
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http://dx.doi.org/10.1111/cod.13236DOI Listing
February 2019
1 Read

Recommendation to include hydroxyethyl (meth)acrylate in the British Baseline Patch Test Series.

Br J Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Royal United Hospital Bath, U.K.

Background: (Meth)acrylates are potent sensitisers and a common cause of allergic contact dermatitis (ACD). The frequency of (meth)acrylate ACD has increased with soaring demand for acrylic nails. A preliminary audit has suggested a significant rate of positive patch tests to (meth)acrylates using aimed testing in patients providing a clear history of exposure. Read More

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http://dx.doi.org/10.1111/bjd.17708DOI Listing
January 2019

Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine in p-phenylenediamine highly allergic volunteers using allergy alert test: the Italian experience.

Eur Ann Allergy Clin Immunol 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Summary: Allergic contact dermatitis after exposure to p-phenylenediamine (PPD)-containing hair dye products is a common and important clinical problem. Because there is a high rate of cross-elicitation of allergic contact dermatitis to other important hair dye products (such as p-toluene diamine [PTD] and other aminophenol hair dyes) in PPD allergic patients, safer alternative dyes with excellent hair coloring options are needed. We studied 2-methoxy methyl-PPD (Me-PPD), a chemical derivative of PPD for tolerance versus cross-elicitation in a cohort of eight PPD-allergic volunteers. Read More

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.82DOI Listing
January 2019
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Contact allergy to methylchloroisothiazolinone/methylisothiazolinone in north-eastern Italy: a temporal trend from 1996 to 2016.

J Eur Acad Dermatol Venereol 2019 Jan 29. Epub 2019 Jan 29.

Clinical Unit of Occupational Medicine, University of Trieste, Trieste, 34129, Italy.

Background: Methylchloroisothiazolinone (MCI)/ methylisothiazolinone (MI) (Kathon CG) is a common preservative used in industrial products, owing to its strong biocide effect. Contact allergy to MCI/MI has been reported in different occupations, including mechanics, hairdressers and healthcare workers.

Objective: To retrospectively analyze the temporal trend of MCI/MI sensitization in north-eastern Italy and to evaluate the associations with occupations in our geographical area. Read More

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http://dx.doi.org/10.1111/jdv.15453DOI Listing
January 2019
3 Reads

IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation.

Proc Natl Acad Sci U S A 2019 Feb 29;116(7):2646-2651. Epub 2019 Jan 29.

Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;

Chronic inflammation's tumor-promoting potential is well-recognized; however, the mechanism underlying the development of this immune environment is unknown. Studying the transition from acute, tumor-suppressive to chronic, tumor-promoting allergic contact dermatitis (ACD) revealed how tumor-promoting chronic inflammation develops. Epidermis-derived interleukin (IL)-33 up-regulation and its induction of regulatory T cell (Treg) accumulation in the skin preceded the transition from acute to chronic ACD and triggered the tumor-promoting immune environment in chronic ACD. Read More

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http://dx.doi.org/10.1073/pnas.1815016116DOI Listing
February 2019

Contact dermatitis to polyacrylamide/C13-4 isoparaffin/laureth-7 mix in an emollient cream for atopic skin.

Contact Dermatitis 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatology, University of Montpellier, France.

A 33-year-old female with a history of atopic dermatitis and seasonal rhino-conjunctivitis was referred to investigate eczema. The atopic dermatitis had been active since infancy, then ceased during her teenage years but relapsed starting with the age of 25, mainly on the hands. She reported a recent flare up of inflammatory skin lesions on her chest, arms and face after applying a moisturizing cream to attenuate atopic skin-related dryness on these areas. Read More

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http://dx.doi.org/10.1111/cod.13234DOI Listing
January 2019
3 Reads

28 days follow up of patch-test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: a multicenter study on behalf of EECDRG.

Contact Dermatitis 2019 Jan 26. Epub 2019 Jan 26.

Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.

Background: It is discussed if routinely patch testing p-phenylenediamine (PPD) 1.0 % petrolatum is safe due to the risk of patch test sensitization. Late appearing patch test reactions may reflect patch test sensitization, but may also be due to a low degree of pre-existing sensitization. Read More

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http://dx.doi.org/10.1111/cod.13235DOI Listing
January 2019
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Filaggrin gene mutations in hand eczema patients in the Indian subcontinent: A prospective case-control study.

Contact Dermatitis 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatology, Venereology and Leprology, Chandigarh, India.

Background: There are no Indian studies on the association between filaggrin mutations and any dermatosis, including hand eczema.

Objectives: To determine the prevalence of filaggrin mutations in Indian hand eczema patients and examine associations between such mutation and any etiologic type of hand eczema.

Materials And Methods: A total of 163 patients and 86 controls were included. Read More

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http://dx.doi.org/10.1111/cod.13233DOI Listing
January 2019
2 Reads

Nickel by proxy.

Contact Dermatitis 2019 Jan 24. Epub 2019 Jan 24.

Department of Dermatology, Changi General Hospital, Singapore.

A 27-year-old Caucasian woman presented with an annular dermatitis on the flexor aspect of her right wrist. She had originally developed dermatitis on her left wrist, as she thought due to an allergic reaction to a metal watch and watch strap which she had recently acquired. This article is protected by copyright. Read More

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http://doi.wiley.com/10.1111/cod.13232
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http://dx.doi.org/10.1111/cod.13232DOI Listing
January 2019
1 Read

Using health insurance administrative data to explore patching testing utilization in Ontario, Canada - An untapped resource.

Contact Dermatitis 2019 Jan 24. Epub 2019 Jan 24.

Dalla Lana School of Public Health, University of Toronto, Canada.

Background: Patch testing is the key diagnostic test for diagnosing allergic contact dermatitis, but there is limited information about the use of patch testing at the population level.

Objectives: To utilize Ontario Health Insurance Plan (OHIP) data to analyse trends in the rate of patch testing in Ontario.

Methods: Patch test billing data submitted to the OHIP between 1992 and 2014 was analysed. Read More

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http://dx.doi.org/10.1111/cod.13229DOI Listing
January 2019
1 Read

Genital dermatitis in a transgender patient returning from Thailand: A diagnostic challenge.

Travel Med Infect Dis 2019 Jan - Feb;27:134-135. Epub 2019 Jan 19.

Park Nicollet Health Services, Department of Dermatology, 7550 34th Ave S, Suite #101, Minneapolis, MN, 55450, USA; University of Minnesota, Department of Dermatology, 516 Delaware St. SE, Mail Code 98, Phillips-Wangensteen Bldg, Suite 4-240, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1016/j.tmaid.2019.01.007DOI Listing
January 2019
1 Read

Topical ketoconazole: a systematic review of current dermatological applications and future developments.

J Dermatolog Treat 2019 Jan 22:1-12. Epub 2019 Jan 22.

a Department of Dermatology , University of California , Irvine , CA, USA.

Introduction: Although labeling changes and market withdrawal have been implemented for oral ketoconazole (KTZ) due to serious adverse effects (AEs), topical KTZ is generally thought to be effective and safe for the treatment of superficial fungal infections. New dermatologic indications for the use of topical KTZ have arisen such as onychomycosis, blepharitis, and hair loss. This article aims to review the literature on topical KTZ's efficacy and AEs, as well as provide an overview on current insights regarding its mechanism of action and upcoming developments. Read More

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http://dx.doi.org/10.1080/09546634.2019.1573309DOI Listing
January 2019
1 Read

Asteraceae species as potential environmental factors of allergy.

Environ Sci Pollut Res Int 2019 Jan 21. Epub 2019 Jan 21.

Department of Botany, Subdepartment of Plants Biology, University of Life Sciences in Lublin, Akademicka 15, 20-950, Lublin, Poland.

The statistics from Europe and the USA have proven a high risk for skin diseases associated with plant contact. Therefore, plant-induced dermatitis is of increasing attention in dermatology. The focus of this paper was to present the current knowledge on aspects of contact allergy related to Asteraceae (Compositae) species. Read More

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http://dx.doi.org/10.1007/s11356-019-04146-wDOI Listing
January 2019
3 Reads

Allergic Contact Dermatitis to a Cell Phone.

Acta Dermatovenerol Croat 2018 Dec;26(4):339-340

Prof. Antonella Tammaro, MD, Sant'Andrea Hospital Sanienza University of Rome, via di Grottarossa 1089, 00100 Roma, Italy;

Dear Editor, Nickel is a ubiquitous allergen and an important cause of allergic contact dermatitis (ACD). Sensitized patients generally develop a localized eruption after cutaneous exposure to nickel, characterized by erythema, vesicles, eczematous plaques, and itching. Nickel is frequently found in several everyday objects. Read More

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December 2018
5 Reads

Textile-induced Vulvar and Perianal Dermatitis.

Contact Dermatitis 2019 Jan 21. Epub 2019 Jan 21.

Texas A&M College of Medicine; Division of Allergy and Immunology, Department of Internal Medicine, and Department of Dermatology at The University of Texas Southwestern Medical Center.

We present a case of chronic vulvar and perianal pruritus that highlights the importance of patch testing for textile allergens in working up cases of chronic anogenital pruritus. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/cod.13227DOI Listing
January 2019
2 Reads

ALLERGIC CONTACT DERMATITIS PROBABLY DUE TO LATANOPROST DURING TREATMENT FOR ALOPECIA AREATA.

Contact Dermatitis 2019 Jan 21. Epub 2019 Jan 21.

Department of Health Sciences, University Magna Graecia, Catanzaro, Italy.

Latanoprost is a phenyl-substituted analogue of prostaglandin F2α used to treat glaucoma (1). Recently, it has been shown to stimulate eyelash hypertrichosis and therefore it has been proposed as a possible treatment for alopecia (2). Despite the extensive use of the drug in ophthalmology, allergic contact dermatitis (ACD) due to latanoprost has rarely been reported in glaucoma patients (3-6). Read More

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http://dx.doi.org/10.1111/cod.13228DOI Listing
January 2019
3 Reads

Allergic reaction to a green tattoo with nickel as a possible allergen.

Contact Dermatitis 2019 Jan 21. Epub 2019 Jan 21.

Academic Tattoo Clinic Amsterdam, Department of Dermatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.

A 40-year-old woman visited the allergology department because of a 10-year-old tattoo on her right lower leg itching for 4 years, specifically, in the green part. The other tattoo areas, red and black, were asymptomatic. There were no triggering factors, and she had no further relevant medical history. Read More

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http://dx.doi.org/10.1111/cod.13226DOI Listing
January 2019
3 Reads
3.747 Impact Factor

Concomitant contact-allergic reactions to iodopropynyl butylcarbamate and iodine.

Contact Dermatitis 2019 Jan 21. Epub 2019 Jan 21.

Department of Dermatology, University Hospital Antwerp (UZA) and University of Antwerp (UA), Antwerp, Belgium.

Background: Iodopropynyl butylcarbamate (IPBC) is a broad-spectrum preservative for use in several product types, including cosmetics in which its concentrations have been limited by EU legislation because of concerns related to its iodine content and release, and risk of subsequent overdose.

Objectives: To report about concomitant patch-test reactions observed with iodine and IPBC in patients sensitized to iodine-containing antiseptics.

Patients: Between 2012 and 2018, 7 patients, six from Belgium and one from France, two suffering from acute dermatitis during surgical interventions, four from dermatitis due to wound treatment, and one from occupational dermatitis, were shown to be sensitized to iodine and/or povidone-iodine (PVP-I) which were considered relevant for their dermatitis. Read More

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http://dx.doi.org/10.1111/cod.13224DOI Listing
January 2019
9 Reads

Consumer protection provided by the European medical device and cosmetic legislation for condoms and lubricants.

Regul Toxicol Pharmacol 2019 Jan 16;103:106-112. Epub 2019 Jan 16.

Medicines and Health Products, Sciensano, Juliette Wytsmanstraat 14, 1050, Brussels, Belgium.

Personal lubricants and lubricants used in condoms contain a number of ingredients which are also present in cosmetic products. These have to comply to the medical device regulation (745/2017) which should provide the same level of consumer protection, if not more, as foreseen in the legal framework of cosmetics (1223/2009). In the current study we developed an analytical method capable of identifying and quantifying 15 ingredients, commonly found in lubricants and cosmetics. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.01.022DOI Listing
January 2019
2 Reads

Inhibitory checkpoint receptors control CD8+ resident memory T cells to prevent skin allergy.

J Allergy Clin Immunol 2019 Jan 14. Epub 2019 Jan 14.

CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; INSERM, U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon, France; CNRS, UMR 5308, Lyon, France. Electronic address:

Background: Tissue-resident memory T cells (Trm) are detrimental in numerous chronic inflammatory diseases, including allergic contact dermatitis (ACD).

Objectives: To analyze the contribution of Trm to the chronicity and severity of ACD and to define the local parameters regulating their development and functions.

Methods: We used an experimental model of ACD, i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193001
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http://dx.doi.org/10.1016/j.jaci.2018.11.048DOI Listing
January 2019
7 Reads

Short exposures and glove protection from (meth)acrylates in nail beauticians - thoughts on a rising concern.

Contact Dermatitis 2019 Jan 17. Epub 2019 Jan 17.

Dermatology Department, Coimbra University Hospital, Coimbra, Portugal.

Allergic contact dermatitis (ACD) from (meth)acrylates in nail aesthetics is a rising concern, namely in the occupational setting (1)(2). Some technicians may have to abandon the job, as allergen avoidance is difficult (3). Aiming to evaluate the capacity of gloves to protect from occupational ACD we performed patch tests with glove fragments placed between the allergens and patients' skin for different time periods, in patients with occupational ACD and positive patch tests to the (meth)acrylates and negative patch tests to gloves. Read More

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http://dx.doi.org/10.1111/cod.13222DOI Listing
January 2019
2 Reads

Allergic contact dermatitis caused by isopropyl methylphenol, a new hapten.

Contact Dermatitis 2019 Jan 17. Epub 2019 Jan 17.

Division of Gynecology, Hanamizuki Clinic, Ushiku, Ibaraki, Japan.

Isopropyl methylphenol (synonym: o-cymen-5-ol, Biosol; CAS no. 3228-02-2) (Fig. 1) is used as anti-mold and general anti-microbial agent, as preservative, and as antioxidant. Read More

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http://dx.doi.org/10.1111/cod.13217DOI Listing
January 2019
3 Reads

Methylisothiazolinone allergic contact dermatitis: assessment of relapses in 139 patients after avoidance advice.

Contact Dermatitis 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, CHU, Université Clermont-Auvergne, Clermont-Ferrand, France.

Background: Methylisothiazolinone (MI) is a preservative responsible for an epidemic of allergic contact dermatitis (ACD). Few studies have been published on the prognosis of patients with MI-induced ACD.

Objectives: To evaluate relapses of MI-induced ACD and difficulties in avoiding MI in patients who had received avoidance advice. Read More

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http://doi.wiley.com/10.1111/cod.13221
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http://dx.doi.org/10.1111/cod.13221DOI Listing
January 2019
7 Reads

Cinnamon-Induced airborne occupational allergic contact dermatitis in a baker: severe flare-up during patch testing.

Authors:
Esen Özkaya

Contact Dermatitis 2019 Jan 17. Epub 2019 Jan 17.

Istanbul University, Istanbul Faculty of Medicine, Department of Dermatology and Venereology, Istanbul, Turkey.

Cinnamon (cassia) is a well known but rarely reported cause of occupational allergic contact dermatitis (OACD) in bakers, presenting almost exclusively with hand eczema (1-6). There is only one reported case of airborne OACD from cinnamon in bakers (2). Herein, a rare case of cinnamon-induced airborne OACD is presented in a baker who reacted with a severe flare-up during patch testing. Read More

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http://doi.wiley.com/10.1111/cod.13219
Publisher Site
http://dx.doi.org/10.1111/cod.13219DOI Listing
January 2019
9 Reads

Low amount of formaldehyde in topical medication and cosmetics: is it clinically relevant?

Contact Dermatitis 2019 Jan 17. Epub 2019 Jan 17.

Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden.

It is difficult for the patients allergic to formaldehyde to totally avoid contact with products containing it as its presence cannot be determined from the ingredient labelling with certainty (1). The aim of this study was to investigate whether formaldehyde could be detected in topical medicines and eye cosmetics when there was no labelled presence of formaldehyde or formaldehyde-releasers. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/cod.13220DOI Listing
January 2019
2 Reads

Capryloyl glycine: a polyfunctional cosmetic ingredient and potential skin sensitizer.

Contact Dermatitis 2019 Jan 16. Epub 2019 Jan 16.

Department of Dermatology, University Hospital Antwerp (UZA) and University of Antwerp (UA), Antwerp, Belgium.

Amino acid alkyl amides (AAAA) are polyfunctional cosmetic ingredients, some also with preservative properties. Here we report a case of allergic contact dermatitis caused by a body lotion containing an AAAA, namely, capryloyl glycine (CG) (syn: caprylyl glycine, N-octanoylglycine; CAS no. 14246-53-8)(Figure 1). Read More

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http://dx.doi.org/10.1111/cod.13215DOI Listing
January 2019
2 Reads

Systemic Treatments for Allergic Contact Dermatitis: The Final Frontier.

Dermatitis 2018 Dec 18. Epub 2018 Dec 18.

Department of Dermatology, Loma Linda University, CA.

Allergic contact dermatitis is a common disease within the family of delayed-type hypersensitivity reactions. In more severe cases of allergic contact dermatitis, topical steroids may prove insufficient, and systemic therapeutic agents are often used. Even when systemic therapies such as cyclosporine lead to improvement, withdrawal of these agents is challenging and can lead to undesirable morbidities. Read More

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http://dx.doi.org/10.1097/DER.0000000000000435DOI Listing
December 2018
2 Reads

Bakuchiol - a new allergen in cosmetics.

Contact Dermatitis 2019 Jan 15. Epub 2019 Jan 15.

Vilnius University, Institute of Clinical Medicine, Clinic of Chest Diseases, Immunology and Allergology, Centre of Pulmonology and Allergology, Vilnius, Lithuania.

A 33-year-old female patient presented to our clinic with an one-year history of erythematous and itchy plaques on the both eyelids, perioral area, and neck (Fig.1). She associated symptoms with food, spices, coffee but not with the cosmetics, as she stated to used only "hypoallergenic cosmetic products for sensitive skin". Read More

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http://dx.doi.org/10.1111/cod.13211DOI Listing
January 2019
2 Reads

Dermatitis and occupational (meth) acrylate contact allergy in nail technicians - a 10 year study.

Contact Dermatitis 2019 Jan 14. Epub 2019 Jan 14.

Lund University, Skåne University Hospital, Department of Occupational and Environmental Dermatology, Malmö, Sweden.

Acrylates and methacrylates, in this report from here on called (meth)acrylates, are present in various coatings, plastics, dental prosthesis, glass substitutes, and acrylic nails. (Meth)acrylic polymers are obtained by polymerization of monomeric derivatives of (meth)acrylic acids, esters being the most important source. Polymerization into acrylic plastics can occur in either room temperature, with heat, or via UV-radiation or visible light This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/cod.13216DOI Listing
January 2019
3 Reads

Patch test reactivity to iodopropynyl butylcarbamate in consecutive patients during seven years.

Contact Dermatitis 2019 Jan 11. Epub 2019 Jan 11.

Department of Dermatology, University Hospital and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Iodopropynyl butylcarbamate (IPBC) is a preservative with highly effective fungicide, parasiticide and bactericide properties. It was authorized in concentrations below 1000 ppm in cosmetics since 1996, and it is now widely used in shampoos, lotions, creams, powders and baby products. IPBC also has widespread application in household products (dish washing liquids), in paints and coatings, and in the wood industry. Read More

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http://dx.doi.org/10.1111/cod.13213DOI Listing
January 2019
2 Reads

A retrospective review of dupilumab for atopic dermatitis patients with allergic contact dermatitis.

J Am Acad Dermatol 2019 Jan 8. Epub 2019 Jan 8.

Tufts Medical Center, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.12.048DOI Listing
January 2019
3 Reads

Allergic contact dermatitis from topical ophthalmic medications: keep an eye on it!

Contact Dermatitis 2019 Jan 10. Epub 2019 Jan 10.

KU Leuven, Department of Microbiology and Immunology, Laboratory of Dermato-Immunology, Leuven, Belgium.

Background: Allergic contact dermatitis (ACD) from topical ophthalmic medications is often overlooked.

Objectives: To study the demographic characteristics, lesion locations, and associated medical conditions of the patients with ACD from ophthalmic drugs, and to identify the most common allergenic culprits, as well as trends in frequencies over the years.

Methods: From January 1990 until December 2016, 16 065 patients were investigated in our clinic; all patients with a positive patch-test reaction to eye medication or its ingredient(s) having caused ACD were studied. Read More

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http://dx.doi.org/10.1111/cod.13209DOI Listing
January 2019
2 Reads

Two differing presentations of periocular dermatitis as a side effect of dupilumab for atopic dermatitis.

Orbit 2019 Jan 10:1-5. Epub 2019 Jan 10.

c Edward S. Harkness Eye Institute , Columbia University Irving Medical Center , New York , NY , USA.

Dupilumab is a monoclonal antibody used to treat atopic dermatitis. Worsening of atopic dermatitis and conjunctivitis following dupilumab use are reported adverse effects; however, there is little reported on the nature and mechanism of these complications. Here, we describe two patients with chronic atopic dermatitis who developed new or severely worsened periocular dermatitis, believed to be a side effect of dupilumab injections, and resolution after its discontinuation. Read More

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https://www.tandfonline.com/doi/full/10.1080/01676830.2018.1
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http://dx.doi.org/10.1080/01676830.2018.1553190DOI Listing
January 2019
4 Reads

Recalcitrant anal and genital pruritus treated with dupilumab.

Authors:
E J Yang J E Murase

Int J Womens Dermatol 2018 Dec 4;4(4):223-226. Epub 2018 Oct 4.

Department of Dermatology, University of California San Francisco, San Francisco, California.

Chronic anogenital pruritus can significantly impair affected patients' quality of life by disrupting their sleep, mood, sexual function, and personal relationships. Although a significant portion of these patients can be managed with hygiene measures, topical therapy, oral anti-pruritics, and allergen avoidance after patch testing, guidelines to treat patients who do not respond to standard therapy have yet to be established. We describe the therapeutic response of a case of anogenital pruritus recalcitrant to multiple topical and systemic therapies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23526475183003
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http://dx.doi.org/10.1016/j.ijwd.2018.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322158PMC
December 2018
7 Reads

The dermal sensitization threshold (DST) approach for mixtures evaluated as negative in in vitro test methods; mixture DST.

J Toxicol Sci 2019 ;44(1):23-34

Safety Science Research Laboratories, Kao Corporation.

Cosmetic ingredients often comprise complex mixtures, such as botanical extracts, which may contain skin sensitizing constituents. In our previous study for the sensitivity of the evaluations of skin sensitizing constituents in mixtures using the binary in vitro test battery with KeratinoSens and h-CLAT, some sensitizers showed higher detection limits in in vitro test methods than in murine local lymph node assays (LLNA). Thus, to minimize the uncertainty associated with decreased sensitivity for these sensitizers, a risk assessment strategy was developed for mixtures with negative results from the binary test battery. Read More

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http://dx.doi.org/10.2131/jts.44.23DOI Listing
January 2019

Sensitivity of KeratinoSens and h-CLAT for detecting minute amounts of sensitizers to evaluate botanical extract.

J Toxicol Sci 2019 ;44(1):13-21

Safety Science Research Laboratories, Kao Corporation.

Cosmetic ingredients are often complex mixtures from natural sources such as botanical extracts that might contain minute amounts of constituents with sensitizing potential. The sensitivity of in vitro skin sensitization test methods such as KeratinoSens and h-CLAT for the detection of minute amounts of sensitizer in mixtures remains unclear. In this study, we assessed the detection sensitivity of the binary test battery comprising KeratinoSens and h-CLAT for minute amounts of sensitizers by comparing the LLNA EC3 (estimated concentration of a substance expected to produce a stimulation index of 3) values to the minimum detection concentrations (MDCs) exceeding the positive criteria for each of the two in vitro test methods. Read More

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http://dx.doi.org/10.2131/jts.44.13DOI Listing
January 2019

Case report: Severe allergic contact dermatitis to topical bufexamac requiring hospitalization.

Contact Dermatitis 2019 Jan 9. Epub 2019 Jan 9.

Skin and Cancer Foundation Inc, Carlton, VIC, Australia.

Bufexamac is a topical non-steroidal anti-inflammatory drug (NSAID) used as a local treatment for various dermatoses despite a propensity to cause severe allergic contact dermatitis (ACD) and a reported lack of efficacy. Bufexamac is still included in medicaments in countries such as Australia and Switzerland despite being banned in the European Union, the United States, New Zealand and Japan. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/cod.13207DOI Listing
January 2019
2 Reads
3.747 Impact Factor