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    15312 results match your criteria Contact Dermatitis Allergic

    1 OF 307

    Clinical utility of marketing terms used for over-the-counter dermatologic products.
    J Dermatolog Treat 2018 Apr 19:1-20. Epub 2018 Apr 19.
    a Department of Dermatology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
    Background: Cosmetic products are commonly marketed using dermatologic terms such as "hypoallergenic," "non-comedogenic," "fragrance-free," etc. The clinical relevance of these claims can be confusing to both patients and clinicians.

    Methods: A systematic review was performed from via a PubMed search of published articles from January 1985 to October 2017 to further describe and elucidate the clinical utility of a predefined list of common dermatologic terms used by pharmaceutical companies to market over the counter products. Read More

    The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice.
    Int Arch Allergy Immunol 2018 Apr 18. Epub 2018 Apr 18.
    Background: Although immunosuppressants for therapy of atopic dermatitis (AD) are still being sought, proteasome inhibitors are also potential candidates for the treatment of AD. Proteasome inhibitors exert various effects by blocking proteasomal degradation and help regulate processes such as apoptosis induction via caspase-9, cell cycle progression via cyclins, NF-κB inactivation via IκB, and downregulation of antigen cross-presentation. The cells targeted by proteasome inhibitors are therefore activated cells undergoing proliferation or differentiation, and antigen-presenting cells carrying out protein degradation. Read More

    Coral Dermatitis or Infectious Dermatitis: Report of a Case of Staphylococcus Aureus Infection of Skin After Scuba Diving.
    Cureus 2018 Feb 16;10(2):e2196. Epub 2018 Feb 16.
    Department of Microbiology, Prathima Institute of Medical Sciences.
    Skin lesion which develops after deep sea diving is termed as coral dermatitis. The corals are known to produce a toxic substance which when comes in to contact with human skin may elicit hypersensitive reactions. Most previous reports highlight the allergic reactions caused by deep sea diving. Read More

    Epidemiology of pediatric nickel sensitivity: Retrospective review of North American Contact Dermatitis Group (NACDG) data 1994-2014.
    J Am Acad Dermatol 2018 Apr 14. Epub 2018 Apr 14.
    Department of Dermatology, University of Cincinnati, Cincinnati, Ohio.
    Background: Nickel is a common allergen responsible for allergic contact dermatitis.

    Objective: To characterize nickel sensitivity in children and compare pediatric cohorts (≤5, 6-12, and 13-18 years).

    Methods: Retrospective, cross-sectional analysis of 1894 pediatric patients patch tested by the North American Contact Dermatitis Group from 1994 to 2014. Read More

    Evaluation of nickel and cobalt release from mobile phone devices used in Brazil.
    An Bras Dermatol 2018 Jan-Feb;93(1):151-153
    Dermatology clinic at Santa Casa de São Paulo - São Paulo (SP), Brazil.
    Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. Read More

    Nickel, chromium and cobalt: the relevant allergens in allergic contact dermatitis. Comparative study between two periods: 1995-2002 and 2003-2015.
    An Bras Dermatol 2018 Jan-Feb;93(1):59-62
    Dermatology Clinic, Santa Casa de São Paulo - São Paulo (SP), Brazil.
    Background: Metals are common agents of allergic contact dermatitis, occupational or not, with decreasing incidence over the last years in some countries that have regulated the amount of nickel in objects.

    Objectives: To analyze and compare with previous studies the profile of metal sensitization between 2003-2015.

    Methods: Patients who underwent patch testing between 2003-2015 were evaluated retrospectively regarding the sensitization rates to metals, the associations between them, the relationship with profession and epidemiology. Read More

    Allergic contact dermatitis caused by isobornyl acrylate in OmniPod, an innovative tubeless insulin pump.
    Contact Dermatitis 2018 Apr 10. Epub 2018 Apr 10.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
    Background: The frequency of allergic contact dermatitis caused by (meth)acrylates is increasing worldwide, and isobornyl acrylate (IBOA) has been identified as a culprit sensitizer in FreeStyle Libre, a medical device used by diabetic patients.

    Objectives: To report on 4 patients sensitized to IBOA contained in OmniPod, a new, tubeless insulin pump, and to describe the clinical and chemical analytical work-up.

    Method: Four patients with eczematous skin eruptions after using OmniPod, including 2 with previous adverse skin reactions to FreeStyle Libre, were patch tested with a baseline series and additional (meth)acrylates, including IBOA in several concentrations and/or vehicles. Read More

    Anti-inflammatory properties of cannabidiol, a non-psychotropic cannabinoid, in experimental allergic contact dermatitis.
    J Pharmacol Exp Ther 2018 Apr 9. Epub 2018 Apr 9.
    Phytocannabinoids modulate inflammatory responses by regulating the production of cytokines in several experimental models of inflammation. Cannabinoid type-2 (CB2) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). We investigated if non-psychotropic cannabinoids like cannabidiol (CBD) produced similar effects in this experimental model of ACD. Read More

    A Review of the Medical Necessity of Comprehensive Patch Testing.
    Dermatitis 2018 Apr 2. Epub 2018 Apr 2.
    Allergic contact dermatitis is associated with significant disease and economic burden in the United States. To properly manage allergic contact dermatitis, it is important to accurately identify the substance(s) implicated in the dermatitis to prevent disease recurrence. The commercially available T. Read More

    Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood.
    JAMA Pediatr 2018 Apr 2:e180315. Epub 2018 Apr 2.
    Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
    Importance: Allergic diseases are prevalent in childhood. Early exposure to medications that can alter the microbiome, including acid-suppressive medications and antibiotics, may influence the likelihood of allergy.

    Objective: To determine whether there is an association between the use of acid-suppressive medications or antibiotics in the first 6 months of infancy and development of allergic diseases in early childhood. Read More

    Anti-inflammatory potency testing of topical corticosteroids and calcineurin inhibitors in human volunteers sensitized to diphenylcyclopropenone.
    Br J Clin Pharmacol 2018 Apr 1. Epub 2018 Apr 1.
    Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, 5000, Odense C, Denmark.
    Aim: To quantify the anti-inflammatory potency of topical corticosteroids and topical calcineurin inhibitors by measuring the contact allergic response to a diphenylcyclopropenone (DPCP) challenge in de novo sensitized human volunteers.

    Methods: Two randomized, double-blind, vehicle-controlled studies were performed encompassing 76 volunteers; 29 in the first and 47 in the second studies. Topical drugs were applied pre- and/or post-treatment in block designs. Read More

    Can the epoxides of cinnamyl alcohol and cinnamal show new cases of contact allergy?
    Contact Dermatitis 2018 Mar 30. Epub 2018 Mar 30.
    Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg, Sweden.
    Background: Cinnamyl alcohol is considered to be a prohapten and prehapten with cinnamal as the main metabolite. However, many individuals who are allergic to cinnamyl alcohol do not react to cinnamal. Sensitizing epoxides of cinnamyl alcohol and cinnamal have been identified as metabolites and autoxidation products of cinnamyl alcohol. Read More

    An unusual presentation of a common condition: Allergic contact dermatitis.
    Int Wound J 2018 Mar 30. Epub 2018 Mar 30.
    Wound Healing Research Unit, Cardiff University, Cardiff, UK.
    Allergic contact dermatitis commonly affects patients with chronic venous leg ulcers and can contribute to impaired wound healing. Many allergens have been identified, and despite the use of advanced dressings, the incidence of allergy has remained high. We discuss an unusual presentation of allergic contact dermatitis in a patient with a chronic wound. Read More

    Contact sensitivity in patients with venous leg ulcer: A multi-centric Indian study.
    Int Wound J 2018 Mar 30. Epub 2018 Mar 30.
    Department of Dermatology, Venereology & Leprology, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
    Venous leg ulcers are the most common form of non-healing leg ulcers. They are subjected to treatments such as topical medications, dressings, and compression therapies. This can lead to exposure to a number of allergens with subsequent sensitisation and contact dermatitis of the regional skin. Read More

    Occupational Contact Dermatitis in the Canadian Aircraft Industry: A 25-Year Retrospective Study.
    Dermatitis 2018 Mar 24. Epub 2018 Mar 24.
    From the Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal General Hospital, Québec, Canada.
    Background: Aircraft building exposes workers to irritant and sensitizing products.

    Objective: The aim of this article was to study occupational dermatoses among aircraft workers over 25 years.

    Methods: The files of aerospace workers referred between 1990 and 2015 were extracted from the database of the McGill University Health Centre contact dermatitis clinic. Read More

    Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized.
    J Eur Acad Dermatol Venereol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Dermatology of the Academic Medical Center, Amsterdam, The Netherlands.
    Background: Concomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult-to-treat. However, contact sensitization in this patient group has barely been studied.

    Objective: To study the occurrence of ACD in a population of difficult-to-treat AD children and adults. Read More

    Delayed-type allergy to cobalt-comparison of a flow cytometric lymphocyte proliferation test with patch testing.
    Contact Dermatitis 2018 Mar 26. Epub 2018 Mar 26.
    Department of Dermatology, Allergy Unit, University Hospital Basel and University of Basel, Basel, Switzerland.
    Background: The patch test is the standard procedure for diagnosing delayed-type sensitization. If a patch test is not possible, the flow cytometric lymphocyte proliferation test (LPT), which determines the number and type of cells responding to a specific antigen in vitro, might be considered as an alternative.

    Objectives: Our aim was to establish a flow cytometric LPT for the detection of delayed-type allergic responses to cobalt, and to determine the correlation between stimulation indices (SIs) in LPT and the grade of patch test reactions. Read More

    Mrgprs activation is required for chronic itch conditions in mice.
    Itch (Phila) 2017 Dec;2(3)
    School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
    Introduction: Chronic itch has been drawing much attention due to its clinical significance and the complexity of its mechanisms. To facilitate the development of anti-itch strategies, it is necessary to investigate the key players in itch sensation under chronic itch conditions. Several members of the Mrgpr family were identified as itch receptors that detect cutaneous pruritogens in primary sensory neurons. Read More

    Adverse events reported to the Food and Drug Administration from 2004 to 2016 for cosmetics and personal care products marketed to newborns and infants.
    Pediatr Dermatol 2018 Mar;35(2):225-229
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
    Background/objectives: Despite their ubiquitous use and several recent health controversies involving cosmetics and personal care products for children, the Food and Drug Administration has little oversight of these products and relies on consumer-submitted adverse event reports. We assessed the recently released Center for Food Safety and Applied Nutrition's Adverse Event Reporting System database for adverse event reports submitted to the Food and Drug Administration for baby personal care products and to determine whether useful insights can be derived.

    Methods: We extracted the Center for Food Safety and Applied Nutrition's Adverse Event Reporting System data file from 2004 to 2016 and examined the subset classified according to the Food and Drug Administration-designated product class as a baby product. Read More

    A retrospective investigation of hexavalent chromium allergy in southern Sweden.
    Contact Dermatitis 2018 Mar 23. Epub 2018 Mar 23.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 214 28 Malmö, Sweden.
    Background: Historically, allergic contact dermatitis caused by hexavalent chromium [Cr(VI)] in cement was the most common cause of invalidity attributable to skin disease in Sweden. Since the legislation to reduce Cr(VI) in cement was introduced in 1989, we rarely see allergic contact dermatitis caused by cement.

    Objectives: To examine the frequency of contact allergy to Cr(VI) in southern Sweden in 2005-2014. Read More

    Further Evidence of Severe Allergic Contact Dermatitis From Isobornyl Acrylate While Using a Continuous Glucose Monitoring System.
    J Diabetes Sci Technol 2018 Mar 1:1932296818762946. Epub 2018 Mar 1.
    3 Science & Co, Düsseldorf, Deutschland, Germany.
    In the past decade, new diabetes technologies, including continuous glucose monitoring (CGM) systems, support patients with diabetes in their daily struggle with achieving a good glucose control. However, shortly after the first CGM systems appeared on the market, also the first concerns about adverse skin reactions were raised. Most patients claimed to suffer from (sometimes severe) skin irritation, or even allergy, which they related to the (acrylate-based) adhesive part of the device. Read More

    Improvement of human cell line activation test (h-CLAT) using short-time exposure methods for prevention of false-negative results.
    J Toxicol Sci 2018 ;43(3):229-240
    Department of Chemical and Energy Engineering, Yokohama National University.
    Recently, animal testing has been affected by increasing ethical, social, and political concerns regarding animal welfare. Several in vitro safety tests for evaluating skin sensitization, such as the human cell line activation test (h-CLAT), have been proposed. However, similar to other tests, the h-CLAT has produced false-negative results, including in tests for acid anhydride and water-insoluble chemicals. Read More

    Skin sensitization quantitative risk assessment for occupational exposure of hairdressers to hair dye ingredients.
    Regul Toxicol Pharmacol 2018 Mar 9;95:124-132. Epub 2018 Mar 9.
    Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
    Occupational exposure of hairdressers to hair dyes has been associated with the development of allergic contact dermatitis (ACD) involving the hands. p-Phenylenediamine (PPD) and toluene-2,5-diamine (PTD) have been implicated as important occupational contact allergens. To conduct a quantitative risk assessment for the induction of contact sensitization to hair dyes in hairdressers, available data from hand rinsing studies following typical occupational exposure conditions to PPD, PTD and resorcinol were assessed. Read More

    Lack of Type 2 Innate Lymphoid Cells Promote a Type I Driven Enhanced Immune Response in Contact Hypersensitivity.
    J Invest Dermatol 2018 Mar 8. Epub 2018 Mar 8.
    Allergy Research Group, Department of Dermatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Experimental Dermatology and Allergy Research Group, Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Campus Giessen, Justus Liebig University, Giessen, Germany. Electronic address:
    Allergic contact dermatitis and its animal model, contact hypersensitivity (CHS), are T cell-mediated inflammatory skin diseases that require activation of the innate immune system. Here we investigate the role of innate lymphoid cells (ILCs) during the elicitation phase of TNCB-induced CHS using Eomes x Rorc(γt)-Cre x Rosa26R reporter mice. Ear swelling responses, cutaneous ILC numbers and cytokine production were determined at different time points. Read More

    Contact dermatitis and patch testing for the allergist.
    Ann Allergy Asthma Immunol 2018 Mar 6. Epub 2018 Mar 6.
    Allergy and Immunology Fellow, NYU Winthrop Hospital, Mineola, New York.
    Objective: Contact dermatitis (CD) is a common disease seen by allergists. Although underutilized, patch testing (PT) remains the gold standard in the diagnosis of allergic CD. It is not difficult to perform, however, the interpretation of the PT, proper classification of the results and determination of their relevance, need an appropriate level of expertise. Read More

    The Anti-Inflammatory Effect of Fructus Kochiae on Allergic Contact Dermatitis Rats via pERK1/2/TLR4/NF-B Pathway Activation.
    Evid Based Complement Alternat Med 2018 4;2018:1096920. Epub 2018 Jan 4.
    Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, China.
    Allergic contact dermatitis (ACD) is a common irritability skin disease, which can be cured by using the Chinese patent medicine. To explore the pharmacological effect of total flavonoids of Fructus Kochiae (FK) on ACD, we used dinitrochlorobenzene- (DNCB-) induced ACD rats. Five groups were used in our experiments. Read More

    IL-26 in allergic contact dermatitis: Resource in a state of readiness.
    Exp Dermatol 2018 Mar 2. Epub 2018 Mar 2.
    Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
    In this study, we investigated the role of IL-26 in allergic contact dermatitis (ACD), highlighting its' contribute in the cytotoxic mechanism responsible for the tissue injury. IL-26 is a signature Th17 cytokine, and immune cells are its predominant sources. Recently, it has shown that Th17 cell-derived-IL-26 functions like an antimicrobial peptide. Read More

    Allergic Contact Dermatitis Due to Paraphenylenediamine: An Update.
    Actas Dermosifiliogr 2018 Feb 26. Epub 2018 Feb 26.
    Servicio de Dermatología, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, España.
    Paraphenylenediamine (PPD) is an amine that is mainly used as an ingredient in hair dyes and henna tattoos. The incidence of allergic contact dermatitis to PPD is increasing, particularly in younger patients. In this article, we review the main sources of PPD and the substances with which it can interact and present a practical algorithm for diagnosing and treating suspected cases of PPD allergy. Read More

    Survey of Patch Test Business Models in the United States by the American Contact Dermatitis Society.
    Dermatitis 2018 Mar/Apr;29(2):85-88
    Background: Allergic contact dermatitis (ACD) remains a significant burden of disease in the United States. Patch testing is the criterion standard for diagnosing ACD, but its use may be limited by reimbursement challenges.

    Objective: This study aimed to assess the current rate of patch test utilization among dermatologists in academic, group, or private practice settings to understand different patch testing business models that address these reimbursement challenges. Read More

    The Role of Cleaning Products in Epidemic Allergic Contact Dermatitis to Methylchloroisothiazolinone/Methylisothiazolinone.
    Dermatitis 2018 Mar/Apr;29(2):77-80
    Background: Sensitivity to methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) has increased rapidly over recent years. This increase is mainly related to the extensive use of high concentrations of MI in cosmetic products, although a growing number of cases of occupational allergic contact dermatitis are caused by MCI/MI.

    Objective: The aim of this study was to examine the association between the increase in MCI/MI sensitization and the work performed by the patients in our area. Read More

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