17,297 results match your criteria Contact Dermatitis Allergic


Approach to allergic contact dermatitis caused by topical medicaments.

Can Fam Physician 2021 Jun;67(6):414-419

Medical Director of the Contact Dermatitis Clinic at St Paul's Hospital in Vancouver.

Objective: To provide an approach to identifying topical medicament ingredients that cause allergic contact dermatitis (ACD) and to recognizing common clinical scenarios in which these ingredients might present.

Sources Of Information: A retrospective chart review was conducted of patients patch tested at the Contact Dermatitis Clinic at St Paul's Hospital in Vancouver, BC, between November 2016 and June 2019. Data from the North American Contact Dermatitis Group from 2015 to 2016 and The Ottawa Hospital patch test clinic from 2000 to 2010 were also reviewed. Read More

View Article and Full-Text PDF

Trends in Patch Testing in the Medicare Part B Fee-for-Service Population.

Dermatitis 2021 Jun 9. Epub 2021 Jun 9.

From the University of Minnesota Medical School Biostatistical Design and Analysis Center, Clinical and Translational Science Institute Division of Healthy Policy and Management, School of Public Health, University of Minnesota Department of Dermatology, University of Minnesota, Minneapolis Veterans Affairs Health Care System Departments of Medicine Dermatology, University of Minnesota Departments of Medicine Dermatology, Minneapolis Veterans Affairs Health Care System, MN.

Background: Patch testing is a vital component of the workup for allergic contact dermatitis. There are limited data on changes of patch testing use among Medicare providers, as well as patch testing reimbursement rates.

Objective: The aim of the study was to evaluate trends in the use of patch testing among various Medicare providers and Medicare patch testing reimbursement. Read More

View Article and Full-Text PDF

Contact Allergens in Prescription Topical Ophthalmic Medications.

Dermatitis 2021 Jun 9. Epub 2021 Jun 9.

From the Department of Dermatology, Park Nicollet Health Services University of Minnesota Medical School, Minneapolis.

Background/objective: Both active and inactive ingredients in topical ophthalmic agents may cause allergic contact dermatitis. Here, we examined ingredients in prescription topical ophthalmic medications available in the United States.

Methods: A comprehensive list of topical ophthalmic medications was generated using AccessPharmacy. Read More

View Article and Full-Text PDF

Further Evidence of Allergic Contact Dermatitis Caused by 2,2'-Methylenebis(6-tert-Butyl-4-Methylphenol) Monoacrylate, a New Sensitizer in the Dexcom G6 Glucose Sensor.

Dermatitis 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden Department of Dermatology, Helsingborg Hospital, Helsingborg, Sweden.

Background: Since the spring of 2020, we have seen several patients experiencing severe allergic contact dermatitis (ACD) from the Dexcom G6 glucose sensor after the composition of the sensor's adhesive patch had been changed. We have previously reported the finding of a new sensitizer, 2,2'-methylenebis(6-tert-butyl-4-methylphenol) monoacrylate, in the Dexcom G6 adhesive patch. Three patients with ACD from Dexcom G6 tested positive to this sensitizer. Read More

View Article and Full-Text PDF

[Handeczema and occupational health and safety measures].

Ned Tijdschr Tandheelkd 2021 Jun;128(6):323-330

In recent decades, hand eczema has been seen more frequently in oral care practices. Hand eczema is a difficult problem, especially since the start of the current COVID-19-pandemic, and can lead to absence due to illness at work. The main trio in the development of eczema is predisposition (atopy), irritation and allergy. Read More

View Article and Full-Text PDF

Analytical survey of tattoo inks - a chemical and legal perspective with focus on sensitizing substances.

Contact Dermatitis 2021 Jun 5. Epub 2021 Jun 5.

Division of Surface and Corrosion Science, Department of Chemistry, School of Engineering Sciences in Chemistry, Biotechnology, and Health, KTH Royal Institute of Technology, Stockholm, Sweden.

Background: Tattoo inks have been reported to elicit allergic contact dermatitis.

Objectives: To investigate the labels and the contents of metals and pigments in tattoo inks, considering restrictions within the European Union.

Methods: 73 tattoo inks currently available on the market, either bought or donated (already used), were investigated for trace metals and pigments by inductively coupled plasma mass spectrometry and by matrix assisted laser desorption/ionization time of flight tandem mass spectrometry. Read More

View Article and Full-Text PDF

Partially airborne allergic contact dermatitis to rubber additives in a car mechanic.

Contact Dermatitis 2021 Jun 5. Epub 2021 Jun 5.

Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany.

View Article and Full-Text PDF

Diagnosis and Management of Dermatitis, Including Atopic, Contact, and Hand Eczemas.

Med Clin North Am 2021 Jul;105(4):611-626

Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Department of Dermatology, Dartmouth-Hitchcock Medical Center, 18 Old Etna Road, Lebanon, NH 03766, USA.

This is a comprehensive and current guide for the diagnosis, differential diagnosis, treatment, and management of eczematous dermatitis, with a focus on atopic dermatitis, irritant and allergic contact dermatitis, hand dermatitis including recurrent vesicular and hyperkeratotic types, asteatotic dermatitis, and nummular or discoid dermatitis. Diagnostic options highlighted are clinical history, physical examination, and patch testing. Therapeutic options highlighted are moisturizers, topical corticosteroids, topical calcineurin inhibitors, crisaborole, phototherapy, and systemic medications including biologics. Read More

View Article and Full-Text PDF

Foot eczema due to octylisothiazolinone in polyurethane boots.

Contact Dermatitis 2021 May 29. Epub 2021 May 29.

Department of Public Health and Clinical Medicine/Dermatology and Venereology, Umeå University hospital, Umeå, Sweden.

View Article and Full-Text PDF

Contact dermatitis.

Nat Rev Dis Primers 2021 May 27;7(1):38. Epub 2021 May 27.

Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.

Contact dermatitis (CD) is among the most common inflammatory dermatological conditions and includes allergic CD, photoallergic CD, irritant CD, photoirritant CD (also called phototoxic CD) and protein CD. Occupational CD can be of any type and is the most prevalent occupational skin disease. Each CD type is characterized by different immunological mechanisms and/or requisite exposures. Read More

View Article and Full-Text PDF

Contact Dermatitis in Children.

Pediatr Ann 2021 May 1;50(5):e198-e205. Epub 2021 May 1.

Contact dermatitis (CD) is commonly encountered in the pediatric population. Allergic and irritant are the two forms of CD and both cause significant clinical problems in children, but they are often underrecognized. The skin lesions in CD may be polymorphic and closely mimic other common pediatric skin diseases. Read More

View Article and Full-Text PDF

Analysis of Prevalence and Risk Factors of Contact Sensitization with respect to the Occupational Profiles in a Greek Patient Cohort: A Retrospective Analysis of a Greek Referral Centre and Future Perspectives.

Biomed Res Int 2021 6;2021:6672506. Epub 2021 May 6.

First Department of Dermatology and Venereology, "Andreas Syggros" Hospital, National and Kapodistrian University of Athens, Medical School, Ionos Dragoumi 5, 11621 Athens, Greece.

Contact dermatitis is a frequent skin disorder related to environmental and occupational etiological factors, which could potentially affect all age groups, as well as both genders. The current study is aimed at exploring the patterns of contact sensitization with respect to the population's occupational patterns in Greece. A retrospective analysis was performed in a cohort of 1978 patients from 2014 to 2016. Read More

View Article and Full-Text PDF

Assessment of cytotoxicity and sensitization potential of intradermally injected tattoo inks in reconstructed human skin.

Contact Dermatitis 2021 May 24. Epub 2021 May 24.

Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Background: The number of people within the European population having at least one tattoo has increased notably, and with it the number of tattoo-associated clinical complications. Despite this, safety information and testing regarding tattoo inks remain limited.

Objective: To assess cytotoxicity and sensitization potential of 16 tattoo inks after intradermal injection into reconstructed human skin (RHS). Read More

View Article and Full-Text PDF

Occupational allergic contact dermatitis to dibutyl maleate and dibutyl fumarate present in a safety shoe: A reason for concern?

Contact Dermatitis 2021 May 24. Epub 2021 May 24.

Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.

View Article and Full-Text PDF

Impact of mono-culture vs. Co-culture of keratinocytes and monocytes on cytokine responses induced by important skin sensitizers.

J Immunotoxicol 2021 Dec;18(1):74-84

Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.

Sensitization to a contact allergen brings with it a lifelong risk to develop allergic contact dermatitis. Inflammation is an important part of the skin sensitizing mechanism, and understanding how different haptens stimulate the immune system, as well as the role played by different cell types present in skin, may be helpful for developing optimized models for risk assessment of new chemicals or mixtures. The aim of this study was to compare the cytokine profile following exposure of cells representing keratinocytes (HaCaT), monocytes (THP-1) and a co-culture of these cells to three clinically important skin sensitizers: cobalt (II) chloride (CoCl), methylisothiazolinone (MI) and p-phenylenediamine (PPD). Read More

View Article and Full-Text PDF
December 2021

Disfiguring angioedema-like airborne dermatitis from methylisothiazolinone in paints: About time to regulate?

Contact Dermatitis 2021 May 21. Epub 2021 May 21.

Department of Dermatology, University Hospital Antwerp (UZA) and Research group Immunology, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.

View Article and Full-Text PDF

Allergic contact dermatitis to an isocyanate based cast in an 8-year-old boy.

Contact Dermatitis 2021 May 21. Epub 2021 May 21.

Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

View Article and Full-Text PDF

Prediction of Skin Sensitization: ?

Front Pharmacol 2021 4;12:655771. Epub 2021 May 4.

Department of Chemistry, National Dong Hwa University, Shoufeng, Taiwan.

Skin direct contact with chemical or physical substances is predisposed to allergic contact dermatitis (ACD), producing various allergic reactions, namely rash, blister, or itchy, in the contacted skin area. ACD can be triggered by various extremely complicated adverse outcome pathways (AOPs) remains to be causal for biosafety warrant. As such, commercial products such as ointments or cosmetics can fulfill the topically safe requirements in animal and non-animal models including allergy. Read More

View Article and Full-Text PDF

Using chemical speciation modelling to discuss variations in patch test reactions to different aluminium and chromium salts.

Contact Dermatitis 2021 May 20. Epub 2021 May 20.

Department of Chemistry, The University of Western Ontario, London, Ontario, Canada.

Background: Allergic contact dermatitis to metals is diagnosed by applying a metal salt in a patch test. The bioavailability of the metal salt might depend on the choice of metal salt, the concentration, sweat composition, and pH.

Objectives: The main purpose of this study was to apply chemical speciation modelling, which is based on experimentally derived input data and calculates the concentrations of chemical forms (species) in solutions, to reproduce and discuss clinical patch test results of aluminium and chromium. Read More

View Article and Full-Text PDF

Contact allergen sensitivity in children with contact dermatitis.

Turk Arch Pediatr 2021 Jan 1;56(1):51-56. Epub 2021 Jan 1.

Pediatric Allergy and Immunology Clinic, University of Health Sciences, Okmeydanı Training and Research Hospital, İstanbul, Turkey.

Objective: Irritant contact dermatitis and Allergic contact dermatitis are two distinct forms of contact dermatitis. Allergic contact dermatitis is a Type 4 (delayed-type) hypersensitivity reaction that occurs during subsequent contact with an allergen to a previously sensitized person. The number of allergens that cause allergic contact dermatitis is increasing day by day. Read More

View Article and Full-Text PDF
January 2021

Anaphylaxis due to potato starch (possibly caused by percutaneous sensitization).

Asia Pac Allergy 2021 Apr 20;11(2):e14. Epub 2021 Apr 20.

Department of Pediatrics, Fujita Health University School of Medicine, Nagoya, Japan.

An 8-year-old boy with poor control of atopic dermatitis could eat potato products such as French fries without restrictions until 21 months of age. However, he developed generalized urticaria after eating potato products at the same age. Therefore, potatoes were excluded from his diet; nevertheless, he continued to consume a very small amount of potato starch but was without symptoms until the age of 8 years. Read More

View Article and Full-Text PDF

Cross-Elicitation to Spiramycin in a Patient With Airborne Allergic Contact Dermatitis to Tylosin.

Dermatitis 2021 May-Jun 01;32(3):e41-e42

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.

View Article and Full-Text PDF

A police case: Finding propylene glycol guilty as culprit allergen.

Contact Dermatitis 2021 May 15. Epub 2021 May 15.

Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France.

View Article and Full-Text PDF

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial.

J Eur Acad Dermatol Venereol 2021 May 14. Epub 2021 May 14.

Departamento de Dermatologia e Radioterapia, FMB-Unesp, Botucatu, Brazil.

Background: Melasma can be refractory to treatment, and relapses are frequent. Thiamidol is a new potent tyrosinase inhibitor that has been found effective as a cosmeceutical for the depigmenting of melasma.

Objective: This study compared the efficacy and tolerability of topical 0. Read More

View Article and Full-Text PDF

Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System.

Mol Cells 2021 May;44(5):310-317

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.

Cluster of differentiation 1 (CD1) is a family of cell-surface glycoproteins that present lipid antigens to T cells. Humans have five CD1 isoforms. CD1a is distinguished by the small volume of its antigen-binding groove and its stunted A' pocket, its high and exclusive expression on Langerhans cells, and its localization in the early endosomal and recycling intracellular trafficking compartments. Read More

View Article and Full-Text PDF

Allergic contact versus irritant contact dermatitis in patients with hard-to-heal leg ulcer: clinical and diagnostic approach.

J Wound Care 2021 May;30(5):394-398

Dermatology Department, University of Chieti and Pescara, Italy.

Background: Dermatitis of surrounding skin may complicate hard-to-heal leg ulcers, delaying wound healing. The coexistence of hard-to-heal leg ulcers and irritant or allergic contact dermatitis may create difficulties for both diagnostic and therapeutic management.

Objective: The aim of our study was to evaluate the incidence of dermatitis occurring in the surrounding skin in a population affected by hard-to-heal leg ulcers during treatment, and to differentiate between allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD) with the use of a patch test. Read More

View Article and Full-Text PDF