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    1 OF 294

    Evaluation of the GARD assay in a blind Cosmetics Europe study.
    ALTEX 2017 Feb 17. Epub 2017 Feb 17.
    Dept. of Immunotechnology, Lund University, Lund, Sweden.
    Chemical hypersensitivity is an immunological response towards foreign substances, commonly referred to as sensitizers, which gives rise primarily to the clinical symptoms known as allergic contact dermatitis. For the purpose of mitigating risks associated with consumer products, chemicals are screened for sensitizing effects. Historically, such predictive screenings have been performed using animal models. Read More

    Allergic contact cheilitis from anethole-containing toothpastes: a practical solution.
    J Eur Acad Dermatol Venereol 2017 Feb 18. Epub 2017 Feb 18.
    Contact Allergy Unit, Department of Dermatology, University Hospital Antwerp, Wilrijkstraat 10, 2650, Antwerp, Belgium.
    In patients presenting with therapy-resistant cheilitis, especially when extending to the perioral skin, patch tests should be performed, even in longstanding cases(1-2) . A 55-year-old woman suffered from an oozing cheilitis for three months with erythema, edema and crusting of the lips and perioral skin (Fig. 1). Read More

    Occupational contact dermatitis from protein in sea products: who is the most affected, the fisherman or the chef?
    J Occup Med Toxicol 2017 10;12. Epub 2017 Feb 10.
    Service de dermato-vénéréologie CHRU Morvan, 2 avenue FOCH, Brest Cedex, 29609 France ; Société Française de Médecine Maritime, 22, Avenue Camille Desmoulins, Brest, 29200 France.
    Background: Protein contact dermatitis has frequently been reported in case studies (usually in cases involving contact with seafood products), but there are very few descriptive series. The objectives of this present study were firstly to determine the incidence of protein contact dermatitis among fishermen in France and compare it with data from onshore work involving seafood exposure. Second, to discover what factors could explain any differences. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    The current spectrum of contact sensitization in patients with chronic leg ulcers or stasis dermatitis - new data from the Information Network of Departments of Dermatology (IVDK).
    Contact Dermatitis 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, University Hospital Erlangen, 91054, Erlangen, Germany.
    Background: Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization.

    Objectives: To identify the current spectrum of contact allergens in these patients.

    Patients And Methods: Data of the Information Network of Departments of Dermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510). Read More

    Contact allergy caused by isothiazolinone derivatives: an overview of non-cosmetic and unusual cosmetic sources.
    Eur J Dermatol 2017 Feb 3. Epub 2017 Feb 3.
    Dermatochemistry laboratory, Institute of Chemistry, University of Strasbourg, Strasbourg, France.
    The isothiazolinone derivatives, methylchloroisothiazolinone (MCI), methylisothiazolinone (MI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT), owing to their strong bactericide, fungicide and algicide properties, are widely used in non-cosmetic products, such as chemical (industrial) products, household detergents, and water-based paints, and the former two derivatives are also used in cosmetic products. However, given their inherent sensitization potential (with MCI > MI > BIT > OIT), allergic contact dermatitis is frequently observed, both in consumers as well as workers in various industries. In this review, we provide an update on the use of MCI/MI and MI in cosmetics, highlighting certain aspects of MI; the use of excessive concentrations, the presence in some less familiar cosmetic products, and the association with unusual clinical manifestations. Read More

    Gallate Contact Dermatitis: Systematic Review and Product Update.
    Dermatitis 2017 Feb 6. Epub 2017 Feb 6.
    From the *Duke University School of Medicine, Duke University; †Duke University Medical Center Library; and ‡Department of Dermatology, Duke University Medical Center, Durham, NC.
    Allergic contact dermatitis related to cosmetic use can result from allergens not routinely evaluated by standard patch test protocols. Propyl, octyl, and dodecyl gallates are commonly used as antioxidant preservatives with reports of associated allergic contact dermatitis in the literature. The objectives of this review were to investigate the role of gallates in allergic contact dermatitis and to explore products containing these preservatives. Read More

    Tetradecanol reduces EL-4 T cell growth by the down regulation of NF-κB mediated IL-2 secretion.
    Eur J Pharmacol 2017 Feb 3. Epub 2017 Feb 3.
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Republic of Korea. Electronic address:
    Tetradecanol is a straight-chain saturated fatty alcohol purified from Dendropanax morbifera leaves. We found that tetradecanol (30μM) reduced specifically the growth of T cells such as EL-4 T cell and isolated murine CD4(+) T cells. In this study, we investigated the effects of tetradecanol on the regulation of interlukin-2 (IL-2), a potent T cell growth factor. Read More

    Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus.
    Parasit Vectors 2017 Jan 31;10(1):51. Epub 2017 Jan 31.
    Departament of Biochemistry and Immunology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, 14049-900, Brazil.
    Background: Ticks attach to and penetrate their hosts' skin and inactivate multiple components of host responses in order to acquire a blood meal. Infestation loads with the cattle tick, Rhipicephalus microplus, are heritable: some breeds carry high loads of reproductively successful ticks, whereas in others, few ticks feed and reproduce efficiently.

    Methods: In order to elucidate the mechanisms that result in the different outcomes of infestations with cattle ticks, we examined global gene expression and inflammation induced by tick bites in skins from one resistant and one susceptible breed of cattle that underwent primary infestations with larvae and nymphs of R. Read More

    Vesicular Contact Reaction May Progress into Erythema Multiforme.
    Acta Dermatovenerol Croat 2016 Dec;24(4):307-309
    Prof. Magdalena Czarnecka-Operacz, MD, PhD, Department of Dermatology, 49 Przybyszewski Str., 60-355 Poznań, Poland.
    Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. Read More

    Structure-Potency Relationships for Epoxides in Allergic Contact Dermatitis.
    Chem Res Toxicol 2017 Feb 25;30(2):524-531. Epub 2017 Jan 25.
    Research Institute for Fragrance Materials, Inc. , 50 Tice Boulevard, Woodcliff Lake, New Jersey 07677, United States.
    Epoxides are known or proposed to be involved in skin sensitization in various ways. Some are encountered directly, and others have been shown to be formed abiotically and metabolically from various unsaturated chemicals. They can react as SN2 electrophiles. Read More

    Experimental patch testing with chromium-coated materials.
    Contact Dermatitis 2017 Jan 25. Epub 2017 Jan 25.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Background: Chromium coatings on metal alloys can be decorative, and prevent corrosion and metal ion release. We recently showed that handling of a chromium-containing disc resulted in chromium deposition on the skin.

    Objectives: To examine patch test reactivity to chromium-coated discs. Read More

    Appropriate Testing of Isothiazolinones in Children.
    Pediatr Dermatol 2017 Jan 23. Epub 2017 Jan 23.
    Department of Dermatology, Loma Linda University, Loma Linda, California.
    Background/objective: The isothiazolinones methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are prevalent pediatric contact sensitizers. MI allergic contact dermatitis (ACD) is underreported in the literature. The objective of the current study was to use a database of provider-reported U. Read More

    Chromium(VI) Contact Dermatitis: Getting Closer to Understanding the Underlying Mechanisms of Toxicity and Sensitization!
    J Invest Dermatol 2017 Feb;137(2):274-277
    Department of Dermatology and Allergology, Technical University of Munich, Munich, Germany.
    Various haptens trigger innate immune pathways and/or induce cytotoxicity as a part of sensitization. Adam et al. decipher in vitro the mechanisms by which chromium(VI) induces inflammation, the likely prerequisites for toxicity, sensitization, and allergic contact dermatitis against chromium(VI). Read More

    High-concentration topical capsaicin may abolish the clinical manifestations of allergic contact dermatitis by effects on induction and elicitation.
    Med Hypotheses 2017 Feb 27;99:53-56. Epub 2016 Dec 27.
    Laboratory of Experimental Cutaneous Pain Research, SMI®, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark. Electronic address:
    Allergic contact dermatitis (ACD) is a common skin condition caused by a type-IV hypersensitivity reaction. Even though ACD is considered as a T-cell mediated disease, indications exists that peptidergic nerve fibers at the site of allergen exposure and associated with the draining lymph node play a prominent role in both induction and elicitation of ACD. This neuro-immune cross talk seems rely on neuropeptides such as Substance P secreted by nerve fiber terminals. Read More

    Extract of Polygala tenuifolia Alleviates Stress-Exacerbated Atopy-Like Skin Dermatitis through the Modulation of Protein Kinase A and p38 Mitogen-Activated Protein Kinase Signaling Pathway.
    Int J Mol Sci 2017 Jan 18;18(1). Epub 2017 Jan 18.
    Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
    Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifolia Willd. Read More

    Epidemiological analysis of occupational dermatitis notified in Brazil in the period 2007 to 2012.
    An Bras Dermatol 2016 Nov-Dec;91(6):732-736
    Universidade Positivo - Curitiba (PR), Brazil.
    Background:: Occupational dermatitis affects the quality of life and productivity of workers. Studies on the subject are scarce in Brazil. It is estimated that the disease is underreported and that many affected patients do not seek health care. Read More

    Prevalence of Preservatives Across All Product Types in the Contact Allergen Management Program.
    Dermatitis 2017 Jan/Feb;28(1):81-87
    From the Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison.
    Background: Preservatives are known causes of allergic contact dermatitis.

    Objective: The aim of this study was to determine the prevalence of preservatives in each product category in the Contact Allergen Management Program and compare prevalence with reported rates of allergic contact dermatitis.

    Methods: Contact Allergen Management Program product information was queried based on the 53 approved preservatives for cosmetic products by the European Union and Association of Southeast Asian Nations plus 5 additional preservatives used in US products. Read More

    The Endocannabinoid System and Its Role in Eczematous Dermatoses.
    Dermatitis 2017 Jan/Feb;28(1):22-32
    From the *Drexel University College of Medicine, Philadelphia, PA; †School of Medicine, ‡Department of Dermatology, University of California, Davis; and §Dermatology Division, Department of Medicine, University of Arizona, Tucson.
    The skin serves as the foremost barrier between the internal body and the external world, providing crucial protection against pathogens and chemical, mechanical, and ultraviolet damages. The skin is a central player in the intricate network of immune, neurologic, and endocrine systems. The endocannabinoid system (ECS) includes an extensive network of bioactive lipid mediators and their receptors, functions to modulate appetite, pain, mood, and memory, and has recently been implicated in skin homeostasis. Read More

    Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils.
    Proc Natl Acad Sci U S A 2017 Jan 17;114(5):1111-1116. Epub 2017 Jan 17.
    Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan
    Th2 immunity plays important roles in both protective and allergic responses. Nevertheless, the nature of antigen-presenting cells responsible for Th2 cell differentiation remains ill-defined compared with the nature of the cells responsible for Th1 and Th17 cell differentiation. Basophils have attracted attention as a producer of Th2-inducing cytokine IL-4, whereas their MHC class II (MHC-II) expression and function as antigen-presenting cells are matters of considerable controversy. Read More

    Bioresorbable vascular scaffold to treat malignant in-stent restenosis in a patient with nickel allergy.
    Cardiovasc Revasc Med 2017 Jan 2. Epub 2017 Jan 2.
    Interventional Cardiology Department, University General Hospital of Ciudad Real, Ciudad Real, Spain.
    Nickel is the most frequent allergen in patients with allergic contact dermatitis and nickel allergy has been associated with recurrent in-stent restenosis. However, it is often misdiagnosed because of a low suspicion threshold. It should be discarded in patients with recurrent in-stent restenosis, especially if their medical history reveals prior contact dermatitis. Read More

    Prediction of skin sensitization potency using machine learning approaches.
    J Appl Toxicol 2017 Jan 10. Epub 2017 Jan 10.
    ILS, Research Triangle Park, NC, 27709, USA.
    The replacement of animal use in testing for regulatory classification of skin sensitizers is a priority for US federal agencies that use data from such testing. Machine learning models that classify substances as sensitizers or non-sensitizers without using animal data have been developed and evaluated. Because some regulatory agencies require that sensitizers be further classified into potency categories, we developed statistical models to predict skin sensitization potency for murine local lymph node assay (LLNA) and human outcomes. Read More

    A derivatization-enhanced detection strategy in mass spectrometry: analysis of 4-hydroxybenzoates and their metabolites after keratinocytes are exposed to UV radiation.
    Sci Rep 2017 Jan 6;7:39907. Epub 2017 Jan 6.
    Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
    4-Hydroxybenzoate is a phenolic derivative of alkyl benzoates and is a widely used preservative in cosmetic and pharmaceutical products. The presence of 4-hydroxybenzoates in the human body may result from the use of pharmaceutical and personal care products. These compounds are also known to exhibit estrogenic and genotoxic activities. Read More

    Involvement of microRNAs in skin disorders: A literature review.
    Allergy Asthma Proc 2017 Jan;38(1):9-15
    Background: miRNAs are a class of noncoding RNA molecules that modulate gene expression after transcription. It is known that miRNAs are involved in various cellular processes of both normal and diseased skin. Recently, differential expressions of miRNAs have been reported and associated with several immunologic and inflammatory disorders, which indicate a common role in fundamental biologic processes. Read More

    Patch Test as a Diagnostic Tool in Hand Eczema.
    J Clin Diagn Res 2016 Nov 1;10(11):WC04-WC07. Epub 2016 Nov 1.
    Professor and Head, Department of Dermatology, Venereology and Leprosy, Pondicherry Institute of Medical Sciences , Pondicherry, India .
    Introduction: Allergic contact dermatitis is an important cause of hand eczema. Patch testing is the only investigation available to prove the diagnosis of allergic contact dermatitis. Exposures to allergens differ according to geographical, occupational, economic and social factors. Read More

    The epidemic of methylisothiazolinone: a European prospective study.
    Contact Dermatitis 2016 Dec 28. Epub 2016 Dec 28.
    Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Background: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required.

    Objectives: To describe demographics and MI exposures for European patients with MI contact allergy. Read More

    The Prevalence of Allergic Rhinitis, Eczema and Asthma in Students of Guidance Schools in Mazandaran Province, Iran.
    Open Access Maced J Med Sci 2016 Dec 11;4(4):619-623. Epub 2016 Oct 11.
    Infectious Disease Research Center with Focus on Nosocomial Infection, Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Eczema, allergic rhinitis and asthma are common chronic allergic disorders in childhood.

    Aim: The aim of this study was to determine the prevalence of common allergic disorders among Iranian guidance schools students in Mazandaran Province, northern Iran.

    Methods: This analytical cross-sectional study was performed on 3000 children aged 11-14 years old during 2012-13 according to ISAAC study. Read More

    Evaluation of concordance between labelling and content of 52 hair dye products: overview of the market of oxidative hair dye Labelling and content of hair dye products.
    Eur J Dermatol 2016 Dec 23. Epub 2016 Dec 23.
    Department of Occupational, Environmental Dermatology, Skåne University Hospital, Malmö, Lund University, Sweden, Jan Waldenströmsgatan 16, pl. 5, 20502, Malmö, Sweden.
    Hair dyes contain strong allergens and are widely available. Correct labelling is a necessity in order to provide information about the contents. To compare the labelling and content of hair dyes. Read More

    Safety and efficacy of prophylactic negative pressure wound therapy following open saphenous vein harvest in cardiac surgery: a feasibility study.
    Interact Cardiovasc Thorac Surg 2016 Dec 26. Epub 2016 Dec 26.
    Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada
    Objectives: Surgical site complications following great saphenous vein (GSV) harvest presents a significant risk of morbidity. Negative pressure wound therapy (NPWT) has shown promise in the treatment and prophylaxis of open wounds and surgical incisions but has not been studied following GSV harvest. We performed a feasibility study examining the use of NPWT following GSV harvest for coronary bypass surgery. Read More

    Effectiveness of the European Chromium VI Directive for cement implementation on occupational allergic contact dermatitis occurrence: Assessment in France and UK.
    Br J Dermatol 2016 Dec 23. Epub 2016 Dec 23.
    Paris Descartes University, Sorbonne Paris Cité, EA 4064, Laboratoire Santé Publique et Environnement, Paris, France.
    Hexavalent chromium is the main sensitizer in wet cement and a common cause of occupational allergic contact dermatitis (OACD), especially among workers in the construction industry.(1,2) The European Chromium VI directive(3) transposed into national regulations in France and UK respectively on May and January 2005, prohibits selling or using of hydrated cement with more than 0.0002% of chromium. Read More

    Patch Test Series for Allergic Perineal Dermatitis in the Diapered Infant.
    Dermatitis 2017 Jan/Feb;28(1):70-75
    From the *Section of Pediatric Dermatology, Children's Hospital of Philadelphia, PA; and †Department of Dermatology, University of Pennsylvania, Philadelphia.
    Background: Allergic perineal dermatitis (PD) due to diaper wipes, topical medicaments, or diapers has been reported. Although patch testing is the criterion standard for detection of allergic contact dermatitis in children, this is limited by body surface area, decreased tolerance of the patch testing procedure, and increased false-positive rates due to irritant reactions. Therefore, a targeted patch testing series is necessary to better screen diapered infants for possible allergic PD. Read More

    Wet Wipe Allergens: Retrospective Analysis From the North American Contact Dermatitis Group 2011-2014.
    Dermatitis 2017 Jan/Feb;28(1):64-69
    From the *Department of Dermatology, Minneapolis Veterans Affairs Medical Center; †HCMC Parkside Occupational and Contact Dermatitis Clinic; ‡Department of Dermatology, University of Minnesota Medical School; §University of Minnesota School of Medicine, Minneapolis; ∥Dartmouth-Hitchcock Medical Center, Lebanon, NH; ¶Department of Dermatology, Keck School of Medicine, Los Angeles, CA; #Ohio State University, Columbus; **University of Louisville, KY; ††Department of Dermatology, Cleveland Clinic, OH; ‡‡Division of Dermatology, Royal Victoria Hospital, McGill University, Montreal, Canada; §§Associates in Dermatology, Fort Myers, FL; ∥∥Department of Dermatology, Pennsylvania State University, State College; ¶¶Division of Dermatology, University of Ottawa, Canada; ##Department of Dermatology, University of California San Francisco; ***Department of Dermatology, University of Cincinnati, OH; and †††Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
    Background: Although there are several case reports of wet wipe-associated contact dermatitis, the prevalence of wipes as a source of allergic contact dermatitis in larger populations and the responsible allergens are largely unknown.

    Objective: The aim of the study was to determine the prevalence of wet wipes as a source of contact allergy and the most commonly associated allergens in a North American tertiary referral patch test population.

    Methods: Data collected from 2011 to 2014 by the North American Contact Dermatitis Group was used to conduct a retrospective cross-sectional analysis of patient demographics and patch test results associated with the triple-digit source code for "wet wipe. Read More

    Essential Oils, Part VI: Sandalwood Oil, Ylang-Ylang Oil, and Jasmine Absolute.
    Dermatitis 2017 Jan/Feb;28(1):14-21
    From acdegroot publishing, Wapserveen, The Netherlands.
    In this article, some aspects of sandalwood oil, ylang-ylang oil, and jasmine absolute are discussed including their botanical origin, uses of the plants and the oils and absolute, chemical composition, contact allergy to and allergic contact dermatitis from these essential oils and absolute, and their causative allergenic ingredients. Read More

    Pediatric patch testing: A 10-year retrospective study.
    Ann Allergy Asthma Immunol 2016 Dec;117(6):661-667
    Department of Dermatology, Cleveland Clinic Foundation and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
    Background: Patch testing is the gold standard for diagnosing allergic contact dermatitis in children.

    Objective: To present a 10-year retrospective review of pediatric patch testing at our institution.

    Methods: Data from patients 18 years or younger who presented for patch testing from February 1, 2005, to May 31, 2015, were entered into a database. Read More

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