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    15237 results match your criteria Contact Dermatitis Allergic

    1 OF 305

    Allergic contact dermatitis to methylisothiazolinone in hair care products: report of a case.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Baylor College of Medicine, Houston, Texas.
    Eccrine spiradenoma (ES) typically presents as a solitary tender lesion. Multiple ES is a rare variant of ES and can present in a segmental, linear, blaschkoid, or zosteriform pattern. The etiology of multiple ES is unknown, but several theories have been suggested including a multipotent stem cell origin. Read More

    Oral involvement of cutaneous T-cell lymphoma.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Tulane University School of Medicine, New Orleans, Louisiana.
    Methylisothiazolinone (MI) is commonly used as a preservative in personal care products and is a frequent cause of allergic contact dermatitis. We present a patient with allergic contact dermatitis caused by MI in hair care products and discuss this allergen to bring attention to this common cause of contact dermatitis, and to highlight its frequent use in hair care products. If allergy to MI is suspected, testing should be performed to this individual preservative, as testing solely for the combination preservative, methylisothiazolinone/methylchloroisothiazolinone (Kathon CG®), may miss many cases of MI allergy. Read More

    European Surveillance System on Contact Allergies (ESSCA): polysensitization, 2009-2014.
    Contact Dermatitis 2018 Feb 22. Epub 2018 Feb 22.
    University of Groningen, University Medical Centre Groningen, Department of Dermatology, 9700 RB Groningen, The Netherlands.
    Background: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life.

    Objectives: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization.

    Methods: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www. Read More

    Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica.
    Molecules 2018 Feb 18;23(2). Epub 2018 Feb 18.
    Laboratory of Pharmacognosy and Natural Product based Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
    Phytochemical isolation of fermented(FAS) which was produced by usingsubsp., exhibited multiple and different composition compared with the original plant. Anti-allergic contact dermatitis (anti-ACD)/anti-atopic dermatitis (anti-AD) activities (visual observation and regulation of Th₁/Th₂ cytokines and IgE in blood) of FAS and the barks ofextract (AS) and the two diarylheptanoids, hirsutenone () and muricarpon B (), which are major components of FAS, were measured in vitro and in vivo. Read More

    Atopy Associated With Positive Patch Test and Possible Allergic Contact Dermatitis.
    J Cutan Med Surg 2018 Feb 1:1203475418758988. Epub 2018 Feb 1.
    2 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.
    Background: Atopy is a genetic predisposition to the development of allergic reactions and the increased production of immunoglobulin E (IgE) upon exposure to environmental antigens. Clinical manifestations of atopy include asthma, atopic dermatitis (AD), and allergic rhinoconjunctivitis (ARC).

    Objective: To determine if cutaneous delayed hypersensitivity reactions (CDHRs) as assessed by patch testing are higher among patients with a history of atopy and with a familial predisposition to atopy. Read More

    A Nonsteroidal Novel Formulation Targeting Inflammatory and Pruritus-Related Mediators Modulates Experimental Allergic Contact Dermatitis.
    Dermatol Ther (Heidelb) 2018 Mar 16;8(1):111-126. Epub 2018 Feb 16.
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
    Introduction: A major clinical challenge in treating allergic contact dermatitis (ACD) is that the first line of treatment is based on the use of corticosteroids. In this study, we aimed to develop a formulation that is devoid of steroids.

    Methods: We used mouse ears treated with dinitrofluorobenzene (DNFB) to induce ACD. Read More

    Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data.
    Drug Des Devel Ther 2018 31;12:241-254. Epub 2018 Jan 31.
    Department of Hematology/Oncology, Levine Cancer Institute, Carolinas Medical Center, Charlotte, NC, USA.
    Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. Read More


    Signs of atopic dermatitis and contact dermatitis affected by distinct H2-haplotype in the NC/Nga genetic background.
    Sci Rep 2018 Feb 7;8(1):2586. Epub 2018 Feb 7.
    Department of Veterinary Pathology, Nippon Veterinary and Life-science University (NVLU), Musashino, Japan.
    We recently advocated in favour of naming a novel H2-haplotype consisting of K, D/L, I-Aand I-Ein the atopic dermatitis (AD) mouse model NC/Nga as "H-2." The role of the H2-haplotype in AD development was investigated in H2-congenic NC/Nga mice (NC.h2and NC. Read More

    Involvement of the Negative Feedback of IL-33 Signaling in the Anti-Inflammatory Effect of Electro-acupuncture on Allergic Contact Dermatitis via Targeting MicroRNA-155 in Mast Cells.
    Inflammation 2018 Feb 5. Epub 2018 Feb 5.
    Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Hubei University of Chinese Medicine, 1 Huangjiahu West Road, Hongshan District, Wuhan, 430065, China.
    In this study, we aimed to investigate the effect of electro-acupuncture (EA) at the Zusanli acupoint (ST36) on interleukin (IL)-33-mediated mast cell activation. Firstly, 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) in rats was developed with or without EA treatment. Then, rat peritoneal mast cells (RPMCs) were obtained and cultured in the presence of IL-33. Read More

    Occupational allergic contact dermatitis caused by antibiotics in healthcare workers - relationship with non-immediate drug eruptions.
    Contact Dermatitis 2018 Feb 5. Epub 2018 Feb 5.
    Dermatology Department, Coimbra Hospital and University Centre (CHUC), Praceta Prof. Mota Pinto, 3000-075, Coimbra, Portugal.
    Background: Occupational allergic contact dermatitis (ACD) in healthcare workers (HCWs) is common, but systemic antibiotics are rarely reported as the cause.

    Objectives: Characterize occupational ACD by handling systemic antibiotics.

    Method: A retrospective analysis was performed of ACD caused by systemic antibiotics among HCWs patch tested between 2010 and 2016 with a series of systemic antibiotics. Read More

    The Journal of Allergy and Clinical Immunology: In Practice 2017 Year in Review.
    J Allergy Clin Immunol Pract 2018 Jan 31. Epub 2018 Jan 31.
    Department of Allergy, Kaiser Permanente Southern California, San Diego, Calif.
    An impressive number of clinically impactful studies and reviews were published in The Journal of Allergy and Clinical Immunology: In Practice in 2017. As a service to our readers, the editors provide this Year in Review article to highlight and contextualize the advances published over the past year. We include information from articles on asthma, allergic rhinitis, rhinosinusitis, immunotherapy, atopic dermatitis, contact dermatitis, food allergy, anaphylaxis, drug hypersensitivity, urticarial/angioedema, eosinophilic disorders, and immunodeficiency. Read More

    Kumkum-induced allergic contact dermatitis: Are we missing the actual culprit?
    Indian J Dermatol Venereol Leprol 2018 ;84(2):153-156
    Department of Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
    Background: Kumkum, made with turmeric and slaked lime along with colour enhancing dyes is known to cause allergic contact dermatitis. The possible contact allergens in kumkum include turmeric, Sudan-1, 4-aminoazobenzene, brilliant lake red R and cananga oil. We report patch test results among patients with suspected contact hypersensitivity to kumkum. Read More

    Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly.
    Arch Toxicol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Internal Medicine, Bundeswehr Hospital, Scharnhorststraße 13, 10115, Berlin, Germany.
    Allergic contact dermatitis is a widespread health disorder and occupational skin disease. Hence, screening for contact-sensitizing chemicals is highly relevant to toxicology, dermatology, and occupational medicine. The use of animal tests for this purpose is constrained by ethical considerations, need for high-throughput screening, and legislation (e. Read More

    Potential of EPR spin-trapping to investigate in situ free radicals generation from skin allergens in reconstructed human epidermis: cumene hydroperoxide as proof of concept.
    Free Radic Res 2018 Jan 15:1-9. Epub 2018 Jan 15.
    a Dermatochemistry Laboratory , University of Strasbourg, CNRS UMR 7177, Institut le Bel , Strasbourg , France.
    The first step in the development of skin sensitisation to a chemical, and in the elicitation of further allergic contact dermatitis (ACD), is the binding of the allergen to skin proteins after penetrating into the epidermis. The so-formed antigenic adduct is then recognised by the immune system as foreign to the body. Sensitising organic hydroperoxides derived from autoxidation of natural terpenes are believed to form antigens through radical-mediated mechanisms, although this has not yet been established. Read More

    Contact sensitization in dental technicians with occupational contact dermatitis. Data of the Information Network of Departments of Dermatology (IVDK) 2001-2015.
    Contact Dermatitis 2018 Jan 12. Epub 2018 Jan 12.
    Information Network of Departments of Dermatology, University Medical Centre Göttingen, 37075 Göttingen, Germany.
    Background: Dental technicians (DTs) are at increased risk for allergic contact sensitization.

    Objectives: To assess the current spectrum of occupational sensitization in DTs with occupational contact dermatitis (OCD).

    Methods: A retrospective analysis of Information Network of Departments of Dermatology patch test data from the years 2001-2015 concerning DTs with OCD was performed. Read More

    Non-occupational allergic contact dermatitis caused by long-lasting nail polish kits for home use: 'the tip of the iceberg'.
    Contact Dermatitis 2018 Jan 12. Epub 2018 Jan 12.
    Dermatology Department, Toledo Hospital Complex, 45071 Toledo, Spain.
    Background: Allergic contact dermatitis (ACD) from (meth)acrylates caused by long lasting nail polish (also known as "permanent", "semi-permanent" or "gel nail polish") has been described both in occupational and non-occupational settings. Inexpensive kits for home use have been available for purchase in many stores or through the Internet.

    Objective: To report on several further cases of consumers sensitised to these nail products. Read More

    Chromium(III) release from chromium-tanned leather elicits allergic contact dermatitis: a use test study.
    Contact Dermatitis 2018 Jan 11. Epub 2018 Jan 11.
    Institute of Environmental Medicine, Karolinska Institute, 171 77, Stockholm, Sweden.
    Background: Chromium (Cr) is a common skin sensitizer. The use of Cr(VI) in leather is restricted in the EU, but that of Cr(III) is not.

    Objectives: To assess whether prolonged exposure to Cr-tanned leather with mainly Cr(III) release may elicit allergic contact dermatitis in Cr-allergic individuals. Read More

    Clinico-etiologic profile of hand dermatitis and patch response of patients at a tertiary hospital in Lagos, Nigeria: results of a prospective observational study.
    Int J Dermatol 2018 Feb 10;57(2):149-155. Epub 2018 Jan 10.
    Kyutis Clinic, Ikoyi Lagos, Nigeria.
    Background: Hand dermatitis is an acute or chronic inflammation of the skin of the hands from a multifactorial cause which may be endogenous, exogenous, or a combination of both. With a wide range in severity and recurrent periods of flares, it has significant impact on the quality of life of its sufferers. A history of atopy predisposes patients to hand dermatitis, but contact dermatitis, either allergic or irritant, is the more commonly implicated factor in the etiology of hand dermatitis. Read More

    Treatment of MCPT8mice with high- or low-dose diphtheria toxin leads to differential depletion of basophils and granulocyte-macrophage progenitors.
    Eur J Immunol 2018 Jan 8. Epub 2018 Jan 8.
    Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U964, Université de Strasbourg, Illkirch, France.
    Basophils have been recently recognized to play important roles in type 2 immune responses during allergies and parasitic infection, largely due to the development of novel tools for the in vivo study of these cells. As such, the genetically-engineered MCPT8mouse line has been used to specifically deplete basophils following treatment with diphtheria toxin (DT). In this study, we showed that DT-injected MCPT8mice exhibited a striking decrease of eosinophils and neutrophils in skin when subjected to a hapten fluorescein isothiocyanate (FITC)-induced allergic contact dermatitis (ACD) experimental protocol. Read More

    Approach to the jewelry aficionado.
    Pediatr Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, Loma Linda University, Loma Linda, CA, USA.
    Children's and teens' frequent use of inexpensive "costume" jewelry exposes them to a variety of contact allergens. Greater use heightens the risk of developing allergic contact dermatitis, especially in the setting of body piercings. Several clinical pearls, prevention strategies, and avoidance alternatives are provided in this article to guide clinicians and patients in the management of jewelry-related allergic contact dermatitis. Read More

    The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis.
    Am J Clin Dermatol 2018 Jan 5. Epub 2018 Jan 5.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, 676 N. St. Clair St, Suite 1600, Chicago, IL, 60611, USA.
    Patients with atopic dermatitis (AD) have increased penetration of allergens, immune dysregulation (including shared cytokine pathways), and frequent use of emollients and topical medications, all of which may predispose toward developing allergic contact dermatitis (ACD). Recent systematic reviews have suggested that ACD is a significant clinical problem in both children and adults with AD. While this remains controversial, ACD remains an important comorbidity and potential exacerbant of AD in clinical practice. Read More

    Suppressive effect of ethanol extract from mango (Mangifera indica L.) peel on IgE production in vitro and in vivo.
    Biosci Biotechnol Biochem 2018 Jan 3:1-8. Epub 2018 Jan 3.
    a Graduate School of Agriculture , Ehime University , Matsuyama , Japan.
    Immunoglobulin E (IgE) is involved in the onset of allergic reaction, and the suppression of IgE production leads to alleviation of allergic symptoms. We found that mango peel ethanol extract (MPE) significantly suppresses IgE production by human myeloma cell line U266 cells, suggesting that MPE has an anti-allergic effect by inhibiting the production of IgE. Although mangiferin is contained in mango, which suppresses IgE production by U266 cells, it was not contained in MPE. Read More

    [Prediction of occupational allergic contact dermatitis induced by formaldehyde by IL17/IL22 secretion cell rest combined with patch test].
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2017 Oct;35(10):727-731
    Department of Preventive medicine, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
    To investigate the possible role of IL17-and IL22-secreting cells combined with patch test for the prediction of formaldehyde-induced occupational allergic contact dermatitis(OACD).From October 2014 to October 2016, totally 131 formaldehyde-exposed workers(49 cases with inflammatory skin lesions,82 ones without inflammatory skin lesions)and 63 non-exposed health controls were recruited. Patch-test was performed in 49 cases of formaldehyde-exposed workers with inflammatory skin lesions. Read More

    A multi-omics analysis reveals metabolic reprogramming in THP-1 cells upon treatment with the contact allergen DNCB.
    Toxicol Appl Pharmacol 2018 Feb 28;340:21-29. Epub 2017 Dec 28.
    German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany.
    Dendritic cell (DC) activation by contact allergens is one of the key steps in the development of allergic contact dermatitis (ACD). Recent evidence suggests that metabolic reprogramming is a prerequisite for the activation of DCs, macrophages and monocytes. Therefore, we used an integrated approach by combining proteomics and metabolomics to investigate the metabolism of human THP-1 cells in response to the strong contact allergen, 2,4-dinitrochlorobenzene (DNCB). Read More

    The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques.
    J Allergy Clin Immunol 2017 Dec 27. Epub 2017 Dec 27.
    Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Japan; Department of Microbiology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan; Division of Mucosal Immunology, Department of Microbiology and Immunology and International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, University of Tokyo, Tokyo, Japan; Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Graduate School of Dentistry, Osaka University, Suita, Japan. Electronic address:
    Background: Metabolites of eicosapentaenoic acid exert various physiologic actions. 17,18-Epoxyeicosatetraenoic acid (17,18-EpETE) is a recently identified new class of antiallergic and anti-inflammatory lipid metabolite of eicosapentaenoic acid, but its effects on skin inflammation and the underlying mechanisms remain to be investigated.

    Objective: We evaluated the effectiveness of 17,18-EpETE for control of contact hypersensitivity in mice and cynomolgus macaques. Read More

    Risk factors for work-related eczema and urticaria among vocational students of agriculture.
    Ann Agric Environ Med 2017 Dec 22;24(4):716-721. Epub 2017 Dec 22.
    Institute of Rural Health, Lublin, Poland.
    Introduction And Objective: Farmers are at high risk of occupational skin diseases which may start already during vocational training. This study was aimed at identification of risk factors for work-related skin diseases among vocational students of agriculture.

    Material And Methods: The study involved 440 students (245 males, 195 females aged 17-21 years) in 11 vocational schools which were at least 100 km from each other. Read More

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