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    15137 results match your criteria Contact Dermatitis Allergic

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    Allergic contact dermatitis caused by 2-ethyl cyanoacrylate contained in glucose sensor sets in two diabetic adults.
    Contact Dermatitis 2017 Dec;77(6):426-429
    Department of Dermatology, Cliniques Universitaires Saint-Luc & Pôle Pneumologie, ORL et Dermatologie Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, 1200 Brussels, Belgium.

    Hypersensitivity to Dental Composites and Resin-Bonding Agents.
    Dent Update 2016 Nov;43(9):836-8, 841-2
    Adverse reactions to dental materials are not an uncommon occurrence, although hypersensitivity has gained much renewed interest in light of public concerns over the safety of dental materials. Hypersensitivity can affect both patients and dental professionals and may manifest as either allergic contact dermatitis or stomatitis. Methacrylic monomers, such as MMA, EGDMA, TEGDMA and Bis-GMA, have been documented as causative allergens, however, little has been documented on the risk of such monomers in composites and bonding agents. Read More

    Classification of consumer products under the EU CLP Regulation: what to consider when caring for contact dermatitis patients.
    Contact Dermatitis 2017 Nov 17. Epub 2017 Nov 17.
    Department of Dermatology, University Hospital Jena, 07743, Jena, Germany.
    Possibly hazardous chemical substances and mixtures need to be clearly and correctly classified and labelled, in order for their hazards to be properly identified and communicated. As dermatologists may encounter cases of harm to patients induced by chemicals, such as chemical burns, and irritant and allergic contact dermatitis, it is essential for them to be aware of the EU CLP Regulation and its potential pitfalls. Manufacturers are required by CLP to classify their products according to the rules given in the CLP Regulation. Read More

    Clinical patterns of Compositae dermatitis in Danish monosensitized patients.
    Contact Dermatitis 2017 Nov 17. Epub 2017 Nov 17.
    Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, 5000, Odense C, Denmark.
    Background: Compositae dermatitis was originally described as airborne contact dermatitis. More recent studies have reported a wider clinical spectrum, but often in polysensitized patients.

    Objective: To evaluate the clinical features of patients sensitized to Compositae only. Read More

    Patch testing in Israeli children with suspected allergic contact dermatitis: A retrospective study and literature review.
    Pediatr Dermatol 2017 Nov 16. Epub 2017 Nov 16.
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background/objectives: Childhood allergic contact dermatitis is recognized as a significant clinical problem. The objective was to evaluate the rate of positive patch tests in Israeli children with clinically suspected allergic contact dermatitis, identify possible sex and age differences, compare results with those in Israeli adults, and review pediatric studies in the literature.

    Methods: The study sample included 343 children and adolescents (197 female, 146 male; 1-18 years of age, mean age 11. Read More

    Kitty Litter Dermatitis from-Bromo-2-Nitropropane-1,3-Diol.
    Skinmed 2017 1;15(5):389-390. Epub 2017 Oct 1.
    Department of Dermatology.
    70-year-old white man presented with a 6-week history of an acute pruritic eruption in the axillary vaults, inguinal folds, and central lumbar area. Due to the severity of the pruritus, the patient was evaluated in the emergency department. He was treated with intramuscular triamcinolone, oral fluconazole, clobetasol cream, and miconazole powder, which provided only minimal relief. Read More

    Two Cases of Lepromatous Leprosy from Exposure to Armadillos in Florida.
    Skinmed 2017 1;15(5):391-393. Epub 2017 Oct 1.
    Department of Dermatopathology, James A. Haley Veterans Hospital, Tampa, FL.
    The first patient was a 41-year-old white man who was referred to the dermatology clinic with a 2-year history of numerous erythematous, hypoesthetic, poorly demarcated papules and plaques present on the trunk, buttocks, and bilateral upper and lower extremities (Figures 1 and 2). The lesions had initially begun as localized erythematous plaques on the right flank, and were diagnosed and treated as cellulitis and allergic contact dermatitis by primary care on separate occasions, with no resolution and continued gradual but persistent spread. Read More

    Piercing and Metal Sensitivity: Extended Analysis of the North American Contact Dermatitis Group Data, 2007-2014.
    Dermatitis 2017 Nov/Dec;28(6):333-341
    From the *Department of Dermatology, Minneapolis Veterans Affairs Medical Center, MN; †Department of Dermatology, University of Minnesota Medical School; and ‡University of Minnesota School of Medicine, Minneapolis; §Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; ∥Department of Dermatology, University of California, San Francisco, CA; ¶Department of Dermatology, Cleveland Clinic, OH; #Division of Dermatology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada; **Department of Dermatology, Keck School of Medicine, Los Angeles, CA; ††University of Louisville, KY; ‡‡Dartmouth-Hitchcock Medical Center, Lebanon, NH; §§Ohio State University, Columbus; ∥∥Associates in Dermatology, Fort Myers, FL; ¶¶Department of Dermatology, Pennsylvania State University, State College; ##Division of Dermatology, University of Ottawa, Ontario, Canada; and ***Department of Dermatology, University of Cincinnati, OH.
    Background: Body piercing provides a unique route of metal exposure.

    Objective: The aim of this study was to update previous analyses using the North American Contact Dermatitis Group data comparing pierced and unpierced individuals.

    Methods: This was a retrospective cross-sectional analysis of 17,912 patients patch tested by the North American Contact Dermatitis Group from 2007 to 2014 for demographics, positive reactions to metals (nickel, cobalt, chromium), and detailed analysis of nickel reactions by age, sex, and source of exposure. Read More

    Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation.
    Free Radic Biol Med 2017 Nov 10;115:31-42. Epub 2017 Nov 10.
    Departments of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. USA; Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. USA.
    Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO2), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Read More

    MCP-1 produced by keratinocytes is associated with leucocyte recruitment during elicitation of nickel-induced occupational allergic contact dermatitis.
    Toxicol Ind Health 2017 Jan 1:748233717738633. Epub 2017 Jan 1.
    4 Department of Medical Quality Control, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
    To investigate the expression profile of monocyte chemoattractant peptide-1 (MCP-1) by keratinocytes after nickel exposure and to identify its role for leucocyte migration during nickel-induced occupational allergic contact dermatitis (OACD), 26 workers diagnosed with nickel-induced OACD were enrolled. Skin biopsies from the positive nickel-challenged sites at different time points were assessed by immunohistochemistry (IHC) for MCP-1, CD68, CD45RO, and in situ hybridization (ISH) for MCP-1, using chronic periumbilical dermititis as controls. The expressions of MCP-1 in HaCaT cell culture after nickel treatment were quantified by enzyme-linked immunosorbent assay. Read More

    Pathomechanisms of Contact Sensitization.
    Curr Allergy Asthma Rep 2017 Nov 11;17(12):83. Epub 2017 Nov 11.
    Allergy Research Group, Department of Dermatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Hauptstrasse 7, 79104, Freiburg im Breisgau, Germany.
    Contact sensitization is the initial process involved in the development of an allergic reaction to xenobiotic environmental substances. Here, we briefly describe the differences between irritant and allergic contact dermatitis. Then, we highlight the essential steps involved in the development of an ACD reaction, i. Read More

    Allergic contact dermatitis caused by calcipotriol.
    Contact Dermatitis 2017 Nov 8. Epub 2017 Nov 8.
    Contact Allergy Unit, Department of Dermatology, University Hospitals KU Leuven, 3000, Leuven, Belgium.
    Background: Calcipotriol, a synthetic vitamin D analogue, is widely used for the topical treatment of psoriasis. It often causes irritant reactions, whereas allergic contact dermatitis has less commonly been reported.

    Objectives: To report on 6 patients (among them an 11-year-old child) who presented with eczematous lesions complicating pre-existing dermatitis, observed in our tertiary referral patch test clinic between 2004 and 2016. Read More

    Allergic Contact Dermatitis Caused by Acrylates in Long-Lasting Nail Polish.
    Actas Dermosifiliogr 2017 Nov 3. Epub 2017 Nov 3.
    Hospital General de Alicante, Alicante, España.
    The first reported cases of allergic contact dermatitis from acrylates in manicure procedures in relation to the application of porcelain nails were published decades ago. The frequency of sensitization has increased due to the introduction of the so-called permanent nail polish containing photo-bonded acrylates, mainly involving the beauticians who apply them, and to a lesser extent, the consumers. The recent commercialized permanent polish kits for domestic use could trigger even higher degrees of sensitization. Read More

    Sensory TRP channels contribute differentially to skin inflammation and persistent itch.
    Nat Commun 2017 Oct 30;8(1):980. Epub 2017 Oct 30.
    Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, 63110, USA.
    Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of ACD induced by squaric acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of pruriceptors. TRPV1 but not TRPA1 channels protect the skin inflammation, as genetic ablation of TRPV1 function or pharmacological ablation of TRPV1-positive sensory nerves promotes cutaneous inflammation in the SADBE-induced ACD. Read More

    Application of in vitro skin penetration measurements to confirm and refine the quantitative skin sensitization risk assessment of methylisothiazolinone.
    Regul Toxicol Pharmacol 2017 Dec 6;91:197-207. Epub 2017 Nov 6.
    Procter & Gamble Services Company NV, Temselaan 100, B-1853 Strombeek-Bever, Belgium. Electronic address:
    Use of quantitative risk assessment (QRA) for assessing the skin sensitization potential of chemicals present in consumer products requires an understanding of hazard and product exposure. In the absence of data, consumer exposure is based on relevant habits and practices and assumes 100% skin uptake of the applied dose. To confirm and refine the exposure, a novel design for in vitro skin exposure measurements was conducted with the preservative, methylisothiazolinone (MI), in beauty care (BC) and household care (HHC) products using realistic consumer exposure conditions. Read More

    UK trends of allergic occupational skin disease attributed to fragrances 1996-2015.
    Contact Dermatitis 2017 Oct 27. Epub 2017 Oct 27.
    Centre for Occupational and Environmental Health, University of Manchester, Manchester, M13 9PL, UK.
    Background: Fragrances are well known to cause allergic contact dermatitis (ACD). Occupationally related cases occur, with certain groups being at higher risk.

    Objective: To investigate the incidence of occupationally related cases of cutaneous fragrance allergy and to evaluate trends. Read More

    Patch Testing with Decyl and Lauryl Glucoside: How Well Does One Screen for Contact Allergic Reactions to the Other?
    Dermatitis 2017 Nov/Dec;28(6):342-345
    From the *Columbia University College of Physicians & Surgeons; and †Department of Dermatology, Columbia University Medical Center, New York, NY.
    Background: Alkyl glucoside surfactants, present in many cosmetic products, can cause allergic contact dermatitis. Decyl glucoside has been part of the North American Contact Dermatitis Group standard allergen panel since 2009.

    Objectives: This study aimed to identify rates and relevance of positive patch test reactions to decyl and lauryl glucosides and to determine how well one of these glucosides screens for contact allergic reactions to the other. Read More

    Allergen of the Year: Propylene Glycol.
    Dermatitis 2017 Nov 10. Epub 2017 Nov 10.
    From the *Department of Dermatology, Loma Linda University, CA and †Northwestern University, Chicago, IL.
    Propylene glycol (PG), an emollient and emulsifier found in cosmetics, medications, and food, has been granted the dubious honor of being named the American Contact Dermatitis Society's Allergen of the Year for 2018. Allergic and irritant contact dermatitis and systemic cutaneous reactions to PG, which has become an increasingly common ingredient, have been documented. Propylene glycol is as contentious as it is ubiquitous because it acts as both a weak sensitizer and an irritant, confounding the results of positive patch tests. Read More

    Contact Allergy to Neem Oil.
    Dermatitis 2017 Nov/Dec;28(6):360-362
    From the *Acdegroot Publishing, Wapserveen; †VieCurie Medisch Centrum, Venlo; and ‡National Institute for Public Health and the Environment Centre for Safety of Substances and Products, Bilthoven, the Netherlands.
    A case of allergic contact dermatitis from neem oil is presented. Neem oil (synonyms: Melia azadirachta seed oil [INCI name], nim oil, margosa oil) is a vegetable (fixed) oil obtained from the seed of the neem tree Azadirachta indica by cold pressing. Contact allergy to neem oil has been described previously in only 3 patients. Read More

    Itching for nail fashion: chronic urticaria and chronic hand dermatitis secondary to acrylate and methacrylate allergy in gel nail varnish.
    Clin Exp Dermatol 2017 Oct 23. Epub 2017 Oct 23.
    Department of Dermatology, Royal North Shore Hospital, St Leonards, NSW, Australia.
    Allergic contact dermatitis (ACD) secondary to acrylates and methacrylates is a well- described occurrence, particularly in those who wear or handle gel nail varnish. Management involves avoidance of the identified allergen. The cause of chronic urticaria (CI) is often not identified, and CU is not known to be associated with acrylates or methacrylates. Read More

    The N-acylethanolamine acid amidase inhibitor ARN077 suppresses inflammation and pruritus in a mouse model of allergic dermatitis.
    J Invest Dermatol 2017 Oct 17. Epub 2017 Oct 17.
    Departments of Anatomy and Neurobiology, Pharmacology and Biological Chemistry, University of California, Irvine 92697-4621, USA. Electronic address:
    N-acylethanolamine acid amidase (NAAA), a cysteine hydrolase highly expressed in macrophages and B-lymphocytes, catalyzes the degradation of palmitoylethanolamide (PEA). PEA is an agonist of peroxisome proliferator-activated receptor-α (PPAR-α) and an important regulator of pain and innate immunity. In the present study, we investigated the properties of the NAAA inhibitor, ARN077, in a mouse model of allergic contact dermatitis. Read More

    Interleukin 31 and skin diseases: A systematic review.
    Allergy Asthma Proc 2017 Nov;38(6):401-408
    Background: Although the pathophysiology of pruritus has been extensively studied in recent years, with many resultant advancements, management of pruritus is still enigmatic, particularly in chronic cutaneous diseases, such as atopic dermatitis, chronic urticaria, allergic contact dermatitis, cutaneous T-cell lymphoma, and uremic pruritus. The recent finding of the involvement of interleukin (IL) 31 in the pathogenesis of chronic pruritus has provided a novel approach to the management of chronic inflammatory skin disorders. The present report provided an in-depth overview of the role of IL-31 in chronic skin diseases and the possible diagnostic and therapeutic applications in the management of these diseases. Read More

    Contact dermatitis caused by a new rubber compound detected in canvas shoes.
    Contact Dermatitis 2017 Oct 17. Epub 2017 Oct 17.
    Department of Dermatology, University Hospital Gent, 9000, Ghent, Belgium.
    Background: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.

    Objectives: To identify the culprit allergen in the shoes.

    Methods: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. Read More

    Allergic Contact Dermatitis by Anatomical Regions: Diagnostic Clues.
    Actas Dermosifiliogr 2017 Oct 11. Epub 2017 Oct 11.
    Servicio de Dermatología, Hospital de la Sant Creu i Sant Pau, Barcelona, España.
    Allergic contact dermatitis (ACD) is a common disease in daily clinical practice, and its prevalence has increased in recent years. It is characterized clinically by varying degrees of erythema, vesiculation, flaking, and lichenification, though these signs can also be present in other eczematous diseases. Patch testing is the main diagnostic tool to confirm ACD, but its accurate interpretation requires correct correlation with the medical history (details of exposure) and physical examination. Read More

    Fragrance allergens linalool and limonene allylic hydroperoxides in skin allergy: mechanisms of action focusing on transcription factor Nrf2.
    Toxicol Sci 2017 Sep 29. Epub 2017 Sep 29.
    UMR996 - Inflammation, Chemokines and Immunopathology, INSERM, Univ Paris-Sud, Université Paris-Saclay, 92296, Châtenay-Malabry, France.
    Allergic contact dermatitis (ACD) is regarded as the most frequent expression of immunotoxicity in humans. Many odorant terpenes commonly used in fragrance compositions are considered as weak skin sensitizers, whereas some of their autoxidation products, allylic hydroperoxides, are classified as strong sensitizers according to the Local Lymph Node Assay (LLNA). However, the mechanism of their effects on the immune system remains unclear. Read More

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