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    14936 results match your criteria Contact Dermatitis Allergic

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    Immunomodulatory Effects of Nanoparticles on Skin Allergy.
    Sci Rep 2017 Jun 21;7(1):3979. Epub 2017 Jun 21.
    Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA.
    In recent years there has been considerable effort to understand the interaction of nanomaterials with the skin. In this study we use an in vivo mouse model of allergic contact dermatitis to investigate how nanoparticles (NPs) may alter allergic responses in skin. We investigate a variety of NPs that vary in size, charge and composition. Read More

    Nickel sulfate promotes IL-17A producing CD4+ T-cells by an IL-23 dependent mechanism regulated by TLR4 and Jak-STAT pathways.
    J Invest Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Inflammation Chimiokines et Immunopathologie, INSERM, Fac. de pharmacie - Univ.Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France. Electronic address:
    Allergic contact dermatitis, caused by nickel, is a delayed-type hypersensitivity reaction and 14.5% of the general population may be affected in Europe. Among a wide range of cytokines, the IL-12 family has unique structural and immunological characteristics. Read More

    Allergic contact dermatitis from ophthalmics.
    Cutan Ocul Toxicol 2017 Mar 6:1-4. Epub 2017 Mar 6.
    c Department of Dermatology , University of California at San Francisco Medical School , San Francisco , CA , USA.
    In this article we summarize the recently described allergens responsible for allergic contact dermatitis due to ophthalmic drugs and contact lens solutions, and emphaage the need on how to perform diagnostic testing in this special clinical entity. Read More

    Patch testing in psoriasis patients: results of a 30-year retrospective study.
    Br J Dermatol 2017 Jun 15. Epub 2017 Jun 15.
    Department of Cutaneous Allergy, St. John's Institute of Dermatology, Guy's Hospital, London, United Kingdom.
    Psoriasis and allergic contact dermatitis (ACD) are common, chronic T-lymphocyte mediated conditions. Although psoriasis patients are commonly referred for patch testing, there are conflicting views on the relationship between contact allergy and psoriasis. Previous studies have suggested ACD is less common in psoriasis(1) and that psoriatics are more difficult to sensitize(1,2,3) . Read More

    Contact Sensitization Due to Allergens in Nail Cosmetics: Identification, Treatment, and Prevention.
    Dermatitis 2017 Jun 13. Epub 2017 Jun 13.
    From the *Icahn School of Medicine at Mount Sinai; and †Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.
    Ingredients found in the nail cosmetic industry, including but not limited to methacrylate and acrylate monomers, formaldehyde, and toluene sulfonamide-formaldehyde resin, can incite allergic contact dermatitis. An eczematous outbreak presents on areas surrounding the nail plate and may spread through contact transfer of the allergen, commonly to the face and neck. Even components that were originally deemed nonsensitizing, such as the ubiquitous cyanoacrylate adhesive family, have been found to be allergenic. Read More

    Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery.
    J Ophthalmic Inflamm Infect 2017 Dec 12;7(1):15. Epub 2017 Jun 12.
    Ophthalmic Surgeons and Consultants of Ohio, Columbus, OH, USA.
    Background: The aim of this study was to evaluate the rate of periocular allergic skin reactions to topical neomycin, polymyxin B, and dexamethasone (NPD) ophthalmic ointment.

    Methods: A consecutive patient prospective study was performed. A total of 522 patients who had a procedure involving incision of the periocular skin with subsequent postoperative application of NPD ophthalmic ointment were included. Read More

    Eyelid Dermatitis Caused by Allergic Contact to Acrylates in Artificial Nails.
    Dermatol Reports 2017 Mar 29;9(1):7198. Epub 2017 May 29.
    Department of Ophthalmology, Hospital Pedro Hispano, Porto, Portugal.
    Over the past few years, there has been an increase in cases of allergic contact dermatitis caused by acrylates, because of the growing popularity of artificial nails. Pathological reactions to artificial nails typically occur on or around the nail area. Eyelid contact dermatitis due to artificial nails is rarely seen, especially in a nonoccupational setting. Read More

    Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis.
    J Allergy Clin Immunol 2017 Jun 2. Epub 2017 Jun 2.
    Medical Research Council (MRC) Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK. Electronic address:
    Background: Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are both forms of eczema and are common inflammatory skin diseases with a central role of Th22-derived IL-22 in their pathogenesis. Although prostaglandin E2 (PGE2) is known to promote inflammation, little is known about its role in processes related to AD and ACD development, including IL-22 up-regulation.

    Objectives: To investigate whether PGE2 has a role in IL-22 induction and development of ACD, which has increased prevalence in patients with AD. Read More

    Management of Atopic Hand Dermatitis.
    Dermatol Clin 2017 Jul;35(3):365-372
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, Hellerup DK-2900, Denmark; National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, Hellerup DK-2900, Denmark. Electronic address:
    This article provides an overview of clinical aspects of hand eczema in patients with atopic dermatitis. Hand eczema can be a part of atopic dermatitis itself or a comorbidity, for example, as irritant or allergic contact dermatitis. When managing hand eczema, it is important to first categorize the subtype and identify potential culprit allergens or irritants. Read More

    A Descriptive Study to Explore the Effect of Peristomal Skin Complications on Quality of Life of Adults With a Permanent Ostomy.
    Ostomy Wound Manage 2017 May;63(5):10-23
    New York University Lutheran Medical Center, Brooklyn, NY.
    Approximately 1 million people are living with an ostomy, and 100 000 to 130 000 new ostomies are created each year. The exact incidence and prevalence of complications are unknown but have been reported to be as high as 70% and to affect quality of life (QoL). Using convenience sampling methods, a descriptive study was conducted to explore QoL scores and peristomal complications reported by adults with a permanent ostomy attending the 2009 United Ostomy Associations of America conference. Read More

    Patch testing in patients with suspected cosmetic dermatitis: A retrospective study.
    J Cosmet Dermatol 2017 Jun 1. Epub 2017 Jun 1.
    Department of Dermatology and STD, Lady Hardinge Medical College, New Delhi, India.
    Background: Growing use of cosmetics has led to an increase in the incidence of allergic contact dermatitis (ACD) to cosmetics. Patch testing helps to confirm allergy to cosmetics and pinpoint the exact offending allergens.

    Aims And Objectives: The study aimed to find the frequency of positive patch test reactions in cases with suspected ACD to cosmetics, and the common allergens responsible for it. Read More

    Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers.
    Basic Clin Pharmacol Toxicol 2017 May 31. Epub 2017 May 31.
    Division of Clinical Pharmacology & Toxicology, University Hospital, Basel, Switzerland.
    Little is known about the course of the plasma concentration and the bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) contained in dermal patches. We compared an etofenamate prototype patch (patent EP 1833471) and a commercially available diclofenac epolamine patch regarding the bioavailability of the active ingredients relative to respective i.m. Read More

    Sensitization and cross-reactivity patterns of contact allergy to diisocyanates and corresponding amines: investigation of diphenylmethane-4,4'-diisocyanate, diphenylmethane-4,4'-diamine, dicyclohexylmethane-4,4'-diisocyanate, and dicylohexylmethane-4,4'-diamine.
    Contact Dermatitis 2017 May 29. Epub 2017 May 29.
    Lund University, Department of Occupational and Environmental Dermatology, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Isocyanates are used in polyurethane production. Dermal exposure to isocyanates can induce contact allergy. The most common isocyanate is diphenylmethane diisocyanate used for industrial purposes. Read More

    Using DR52c/Ni(2+) mimotope tetramers to detect Ni(2+) reactive CD4(+) T cells in patients with joint replacement failure.
    Toxicol Appl Pharmacol 2017 May 26. Epub 2017 May 26.
    Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:
    T cell mediated hypersensitivity to nickel (Ni(2+)) is one of the most common causes of allergic contact dermatitis. Ni(2+) sensitization may also contribute to the failure of Ni(2+) containing joint implants, and revision to non-Ni(2+) containing hardware can be costly and debilitating. Previously, we identified Ni(2+) mimotope peptides, which are reactive to a CD4(+) T cell clone, ANi2. Read More

    Allergic contact dermatitis in preservatives: current standing and future options.
    Curr Opin Allergy Clin Immunol 2017 May 25. Epub 2017 May 25.
    Department of Dermatology, Hospital del Mar - Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
    Purpose Of Review: Preservatives are well known skin sensitizers and represent one of the main causes of contact allergy. The purpose of this article is to review the current state of contact sensitization induced by preservatives and point future alternatives for products' preservation.

    Recent Findings: Isothiazolinones currently are the most common preservatives responsible of contact allergy in Europe and in the United States, and although some regulatory interventions have been taken place, the current contact allergy outbreak is not yet under control. Read More

    Probabilistic derivation of the interspecies assessment factor for skin sensitization.
    Regul Toxicol Pharmacol 2017 May 22;88:34-44. Epub 2017 May 22.
    National Institute for Public Health and the Environment, Centre for Safety of Substances and Products, Bilthoven, The Netherlands. Electronic address:
    An interspecies sensitization assessment factor (SAF) is used in the quantitative risk assessment (QRA) for skin sensitization when a murine-based NESIL (No Expected Sensitization Induction Level) is taken as point of departure. Several studies showed that, on average, the murine sensitization threshold is in good correspondence with that determined in humans. However, on an individual level, the murine and human sensitization thresholds may differ considerably. Read More

    Comparison and validation of an in vitro skin sensitization strategy using a data set of 33 chemical references.
    Toxicol In Vitro 2017 May 21. Epub 2017 May 21.
    Pierre Fabre Dermo-Cosmetics Research & Development, Toxicology Division, Safety Department, Toulouse, France.
    Allergic contact dermatitis (ACD) is an adverse health effect that develops following repeated exposure to skin sensitizing chemicals. An animal testing ban has been applied in EU, leading to development of reliably predictive non-animal methods. Several in vitro methods have been developed as alternatives but one single non-animal test method is not been sufficient to fully address since the LLNA test ban. Read More

    Complementary Intradermal and Patch Testing for Increased Diagnostic Accuracy of Nickel Allergy in Non-Celiac Wheat Insensitivity.
    Nutrients 2017 May 24;9(6). Epub 2017 May 24.
    Department of Dermatology, Loma Linda University, 11370 Anderson Street, Suite 2600, Loma Linda, CA 92354, USA.
    D'Alcamo et al. astutely highlighted a potential immunologic association between nickel allergy, determined by positive epicutaneous patch testing, and the rise of non-celiac wheat sensitivity (NCWS) in the world of gluten-related diseases. Consecutive algorithms including both patch and intradermal testing could provide vital information to more accurately define the patient populations with NCWS, systemic nickel allergy syndrome, and nickel-associated allergic contact dermatitis. Read More

    Evaluation and Management of Patch Test-Negative Patients With Generalized Dermatitis.
    Dermatitis 2017 May 23. Epub 2017 May 23.
    From the Geisinger Medical Center, Danville, PA.
    Background: Patients with generalized dermatitis are common in dermatology practices. Allergic contact dermatitis is often suspected, and patients frequently undergo patch testing. When patch testing result is negative, further evaluation and management of these patients are challenging. Read More

    [CHRONIC DERMATITIS OF THE DORSUM OF THE FEET AND SHINS, DUE TO ALLERGIC CONTACT DERMATITIS TO LEATHER PRODUCTS].
    Harefuah 2016 Oct;155(10):608-610
    Department of Dermatology, Hadassah Hebrew University Medical Center, Jerusalem Israel.
    Introduction: A 40 year old woman presented with dermatitis mainly involving her dorsal feet and shins, a condition which was present for a prolonged period of time. The distribution was suggestive of allergic contact dermatitis, possibly to her shoes. Patch tests disclosed allergy to chromates, cobalt, colophony, all present in leather products, and allergy to myroxylon pereirae (Balsam of Peru). Read More

    Diagnosis and management of allergic contact dermatitis in children: common allergens that can be easily missed.
    Curr Opin Pediatr 2017 May 18. Epub 2017 May 18.
    aDepartment of Dermatology bDepartment of Medicine, Loma Linda University, Loma Linda, California, USA cDepartment of Dermatology, Crosshouse Hospital, Kilmarnock, Scotland, UK.
    Purpose Of Review: Contact dermatitis is an economically burdensome pediatric disease, and it is important to know the top allergens that have remained as top offenders for over the last decade.

    Recent Findings: A comparative analysis of the 20-allergen screen was done against the current top 40 pediatric allergens, and it revealed that the 20-allergen screening series would have theoretically only captured 47.5% of the relevant contact allergens (52. Read More

    Allergic Contact Dermatitis Due to Methylisothiazolinone in a Young Girl's Laundry Detergent.
    Pediatr Dermatol 2017 May 19. Epub 2017 May 19.
    Department of Dermatology, University of California, San Diego, Rady Children's Hospital, San Diego, California.
    Methylisothiazolinone (MI) is an emerging and increasing cause of allergic contact dermatitis (ACD) in children. We present the case of a 7-year-old girl with an unusual dermatitis suspicious for contact allergy. Patch testing confirmed allergy to MI, found only in the patient's laundry detergent. Read More

    Anti-allergic and Profilaggrin (ProFLG)-mRNA expression modulatory effects of sacran.
    Int J Biol Macromol 2017 May 15. Epub 2017 May 15.
    Graduate School of Advanced Science and Technology, Energy and Environment Area, Japan Advanced Institute of Science and Technology, Nomi, Japan. Electronic address:
    Atopic dermatitis (AD) is a skin disorder characterized by filaggrin (FLG) defect. We evaluated sacran's effects on dust-mite extracts (DME)-induced AD-like disease and also its effect on profilaggrin (proFLG) in a murine model of 2,4-dinitroflurobenze (DNFB)-induced contact hypersensitivity. In the murine AD-like disease model, allergic NC/Nga mice (N=60) were randomly divided into five treatment groups of 12 animals each: 0. Read More

    [Skin diseases associated with environmental factors].
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2017 Jun;60(6):605-617
    Abteilung Allergologie, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen, Deutschland.
    Background: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease.

    Objectives: Provide an overview of non-allergic skin diseases associated with environmental factors.

    Materials And Methods: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. Read More

    Epidemic of Isothiazolinone Allergy in North America: Prevalence Data From the North American Contact Dermatitis Group, 2013-2014.
    Dermatitis 2017 May/Jun;28(3):204-209
    From the *Division of Dermatology, The Ohio State University, Columbus; †The University of Minnesota and the Minneapolis VAMC; ‡University of California, San Francisco; §Cleveland Clinic, OH; ∥McGill University Health Centre, Montreal, Canada; ¶University of Toronto, Canada; #Associates in Dermatology, Fort Myers, FL; **Group Health Associates, Cincinnati, OH; ††Dartmouth Medical Center, Lebanon, NH; ‡‡St. Luke's Roosevelt Hospital Center, New York; §§Dermatology Specialists, Louisville, KY; ∥∥Pennsylvania State University, Hershey, PA; ¶¶University of Ottawa, Ontario, Canada; ##Columbia University Medical Center, New York, NY.
    Background: Preservative sensitivity patterns evolve with changing use patterns in products. During the last decade, the use of methylisothiazolinone (MI) at higher concentrations in both leave-on and rinse-off products has significantly increased. This is the first North American Contact Dermatitis Group reporting cycle that includes both methylchloroisothiazolinone (MCI)/MI and MI data. Read More

    Preventing Occupational Skin Disease: A Review of Training Programs.
    Dermatitis 2017 May/Jun;28(3):169-182
    From the *Dalla Lana School of Public Health, University of Toronto, †Department of Occupational Health and Centre for Urban Health Solutions, Li Ka Shing, Knowledge Institute, St Michael's Hospital; ‡Occupational Cancer Research Centre, Cancer Care Ontario; and §Department of Medicine, University of Toronto, Canada.
    Occupational contact dermatitis (OCD) is a common occupational disease that impacts a variety of worker groups. Skin protection and disease prevention training programs have shown promise for improving prevention practices and reducing the incidence of OCD. This review details the features of training programs for primary prevention of OCD and identifies gaps in the literature. Read More

    Skin diseases and tattoos: a five-year experience.
    G Ital Dermatol Venereol 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, University of Naples Federico II, Naples, Italy -
    Background: Decorative tattooing as a body art form underwent an exponential increase during the last two decades, particularly among teenagers and young adults. Consequently, the number of reported adverse reactions after tattooing has increased. The most frequent reported skin reactions to tattoo include infectious (bacterial, viral, fungal) or inflammatory (allergic contact dermatitis and granulomatous reaction) diseases. Read More

    Diagnosing Allergic Contact Dermatitis Through Elimination, Perception, Detection and Deduction.
    Am J Clin Dermatol 2017 May 15. Epub 2017 May 15.
    Department of Cutaneous Allergy, St. John's Institute of Dermatology, Guy's Hospital, King's College, London, UK.
    Several authors have commented upon the skills of detection required in making a diagnosis of allergic contact dermatitis. Here, we emphasise the search for clues in a systematic manner. We describe four stages as part of a systematic method for diagnosing allergic contact dermatitis. Read More

    Allergic contact dermatitis caused by (meth)acrylates in nail cosmetic products in users and nail technicians - a 5-year study.
    Contact Dermatitis 2017 May 15. Epub 2017 May 15.
    Clinic of Dermatology, University Hospital and Faculty of Medicine, University of Coimbra, 3000-075, Coimbra, Portugal.
    Background: The increasing use of long-lasting nail aesthetic products has led to a growing number of cases of allergic contact dermatitis (ACD) caused by (meth)acrylates in recent years.

    Objectives: To provide information on ACD caused by (meth)acrylates related to nail cosmetic products.

    Methods: We retrospectively reviewed files of patients with ACD caused by (meth)acrylates related to nail cosmetic products, who were patch tested between January 2011 and December 2015 in 13 departments of dermatology in Portugal. Read More

    Allergic and nonallergic rhinitis and skin sensitization to metals: is there a link?
    Eur Ann Allergy Clin Immunol 2017 May;49(3):106-109
    Allergy and Respiratory Diseases, IRCCS San Martino-Ist-University of Genoa, Genoa, Italy. Phone: +39 010 353 8904 E-mail:
    Summary: Background. Chromium, Cobalt and Nickel are responsible for contact dermatitis, that is largely prevalent in the general population. They can act also as irritants in the upper and lower respiratory airways. Read More


    Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis.
    Contact Dermatitis 2017 Jul 12;77(1):1-16. Epub 2017 May 12.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Read More

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