53,358 results match your criteria Consultant For Pediatricians [Journal]


Quality of Lactation Studies Investigating Antidepressants.

Breastfeed Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Pharmacy, Isala, Zwolle, the Netherlands.

The aim of this study was to determine the quality of lactation studies investigating antidepressants in breast milk according to the Food and Drug Administration (FDA) draft guidelines and the article of Begg, published in the official journal of the International Lactation Consultant Association (ILCA). We used PubMed and LactMed for the literature search. Furthermore, cross references were searched for additional studies. Read More

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http://dx.doi.org/10.1089/bfm.2019.0021DOI Listing

A qualitative descriptive analysis of nurses' perceptions of hospice care for deceased children following organ donation in hospice cool rooms.

Int J Palliat Nurs 2019 Apr;25(4):166-175

Practice Educator, Martin House Children's Hospice, Wetherby, UK.

Background: Following organ donation, bodies of children are generally cared for in hospital mortuaries or by funeral directors, and their families are offered little routine bereavement support. A partnership between an organ donation nursing team and regional children's hospice trialled an initiative where families were offered bereavement support from the hospice, and their child's body was cared for in a 'cool room' after death. Hospice services are usually restricted to children with life-limiting conditions, and their families. Read More

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http://dx.doi.org/10.12968/ijpn.2019.25.4.166DOI Listing
April 2019
1 Read

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.

J Med Chem 2019 Apr 23. Epub 2019 Apr 23.

Albany Molecular Research, Inc. , 21 Corporate Circle , Albany , New York 12203 , United States.

Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis. The design and optimization of lead compounds was based on iterative analysis of X-ray crystal structures combined with metabolite identification. Selectivity for the activated, dimeric form of PDE4D provided potent memory enhancing effects in a mouse model of novel object recognition with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors that lack subtype selectivity. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00193DOI Listing

Safety and efficacy of eculizumab for the prevention of antibody-mediated rejection after deceased-donor kidney transplantation in patients with preformed donor-specific antibodies.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Formerly Alexion Pharmaceuticals, Boston, Massachusetts.

The presence of preformed donor-specific antibodies (DSAs) in transplant recipients increases risk of acute antibody-mediated rejection (AMR). Results of an open-label, single-arm trial to evaluate safety and efficacy of eculizumab in preventing acute AMR in recipients of deceased-donor kidney transplants with preformed DSAs are reported. Participants received eculizumab as follows: 1200 mg immediately before reperfusion, 900 mg on posttransplantation days 1, 7, 14, 21 and 28, and 1200 mg at weeks 5, 7 and 9. Read More

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http://dx.doi.org/10.1111/ajt.15397DOI Listing

How Should Physicians Help Patients Understand Unknowns of Nanoparticle-Based Medicines?

AMA J Ethics 2019 Apr 1;21(4):E324-331. Epub 2019 Apr 1.

An assistant professor of pediatrics at the Wake Forest School of Medicine in Winston-Salem, North Carolina, where she is also a clinical ethics consultant and a medical director of the Brenner Children's Hospital Care Always™ neonatal/perinatal palliative care program.

When a patient wants to enroll in a clinical trial to gain early access to an apparently promising but unproven intervention, her physician should clarify differences between participating in research and receiving treatment to help her avoid therapeutic misconception, make a thoughtful decision, and consider relevant clinical and ethical details. These include a patient's disease and treatment experiences, needs, interests, values, the design and phase of the trial, and the nature of the intervention being studied. When an unproven intervention is a nanodrug, a physician's role is especially difficult, because though nanomedicine might offer real benefits, it can also pose unexpected or even unprecedented harms. Read More

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http://dx.doi.org/10.1001/amajethics.2019.324DOI Listing

Author's reply.

Br J Psychiatry 2019 May;214(5):307

Emeritus Professor,University of Warwick,UK.

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http://dx.doi.org/10.1192/bjp.2019.68DOI Listing

Author's reply.

Authors:
Matthew Taylor

Br J Psychiatry 2019 May;214(5):306-307

Consultant Psychiatrist,University Department of Psychiatry,Warneford Hospital,Oxford.

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http://dx.doi.org/10.1192/bjp.2019.66DOI Listing

#BJPsych and social media - likes, followers and leading?

Br J Psychiatry 2019 May;214(5):245-247

Consultant Psychiatrist,Clinical Director,Oxleas National Health Service Foundation Trust; and Senior Lecturer,King's College London,UK.

SummaryThis article explores the growing interface between social media and academic publishing. We discuss how the British Journal of Psychiatry (BJPsych) and other scientific journals are engaging with social media to communicate in a digital world. A growing body of evidence suggests that public visibility and constructive conversation on social media networks can be beneficial for researchers and clinicians, influencing research in a number of key ways. Read More

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http://dx.doi.org/10.1192/bjp.2019.6DOI Listing

Continuity of care and clinical outcomes in the community for people with severe mental illness.

Br J Psychiatry 2019 May;214(5):273-278

Professor of Psychiatric Research,Institute of Psychiatry, Psychology and Neuroscience,King's College London,UK.

Background: High continuity of care is prized by users of mental health services and lauded in health policy. It is especially important in long-term conditions like schizophrenia. However, it is not routinely measured, and therefore not often evaluated when service reorganisations take place. Read More

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http://dx.doi.org/10.1192/bjp.2018.261DOI Listing

Long-Term Outcomes Following Laparoscopic Repair of Large Hiatus Hernias Performed by Trainees Versus Consultant Surgeons.

J Gastrointest Surg 2019 Apr 22. Epub 2019 Apr 22.

Discipline of Surgery Flinders University, Flinders Medical Centre, Bedford Park, South Australia, 5042, Australia.

Background: The laparoscopic approach is the preferred method for repair of large hiatus hernias but can be technically challenging. Training surgeons need experience as the primary operator to gain competency in this operation. However, learning the procedure should not compromise the functional long-term outcome for patients. Read More

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http://link.springer.com/10.1007/s11605-019-04218-9
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http://dx.doi.org/10.1007/s11605-019-04218-9DOI Listing
April 2019
1 Read

Religion, Authenticity, and Clinical Ethics Consultation.

Authors:
J Clint Parker

HEC Forum 2019 Apr 22. Epub 2019 Apr 22.

Department of Bioethics and Interdisciplinary Studies, Brody School of Medicine, East Carolina University, 600 Moye Blvd., Brody 2S-17, Mailstop 641, Greenville, NC, 27834, USA.

A clinical ethics consultant (CEC) may, at times, be called upon to make independent substantive moral judgments and then offer justifications for those judgments. A CEC does not act unprofessionally by utilizing background beliefs that are religious in nature to justify those judgments. It is important, however, for a CEC to make such judgments authentically and, when asked, to offer up one's reasons for why one believes the judgment is true in a transparent fashion. Read More

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http://dx.doi.org/10.1007/s10730-019-09375-7DOI Listing

Evaluation of a re-useable bronchoscopy biosimulator with ventilated lungs.

ERJ Open Res 2019 Apr 15;5(2). Epub 2019 Apr 15.

Royal Brompton Hospital, London, UK.

Background: Restrictions on respiratory trainee time and access to procedures reduce the opportunities to acquire necessary skills in bronchoscopy. Simulation, not subject to such impediments, is a useful supplementary aid to teaching bronchoscopic techniques in a safe environment but there is a limited choice of simulators that are sufficiently realistic and not prohibitively expensive. This study evaluated a low-cost device that simulates an intubated and ventilated patient, employing re-useable, inflatable, BioFlex-preserved, porcine lungs. Read More

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http://dx.doi.org/10.1183/23120541.00035-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469070PMC

Radiographic and Histological Analysis of a Synthetic Bone Graft Substitute Eluting Gentamicin in the Treatment of Chronic Osteomyelitis.

J Bone Jt Infect 2019 16;4(2):76-84. Epub 2019 Mar 16.

Consultant in Limb Reconstruction Surgery, Honorary Senior Lecturer in Orthopaedic Surgery, Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford Radcliffe Hospitals NHS Foundation Trust, Oxford, UK.

Managing chronic osteomyelitis can be challenging and attention to the osseous dead-space left following resection is an important part of successful treatment. We assess radiographic bone healing following implantation of a gentamicin-eluting synthetic bone graft substitute (gBGS) used at chronic osteomyelitis (cOM) resection. We also describe histological carrier changes from biopsies in nine cases at various time points. Read More

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http://dx.doi.org/10.7150/jbji.31592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470655PMC

Transitional fetal hemodynamics and gas exchange in premature postpartum adaptation: immediate vs. delayed cord clamping.

Matern Health Neonatol Perinatol 2019 12;5. Epub 2019 Apr 12.

5Department of Mechanical Engineering, Koç Univeresity, Istanbul, Turkey.

Background: Recent studies suggest that delayed cord clamping (DCC) is advantageous for achieving hemodynamic stability and improving oxygenation compared to the immediate cord clamping (ICC) during fetal-to-neonatal transition yet there is no quantitative information on hemodynamics and respiration, particularly for pre-term babies and fetal disease states. Therefore, the objective of this study is to investigate the effects of ICC and DCC on hemodynamics and respiration of the newborn preterm infants in the presence of common vascular pathologies.

Methods: A computational lumped parameter model (LPM) of the placental and respiratory system of a fetus is developed to predict blood pressure, flow rates and oxygen saturation. Read More

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https://mhnpjournal.biomedcentral.com/articles/10.1186/s4074
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http://dx.doi.org/10.1186/s40748-019-0100-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460527PMC
April 2019
1 Read

Treatment of Portopulmonary Hypertension With Macitentan in Patients With Cirrhosis.

Authors:
Michael J Krowka

Gastroenterol Hepatol (N Y) 2019 Feb;15(2):108-110

Professor of Medicine Consultant, Division of Gastroenterology/Hepatology and Division of Pulmonary/Critical Care Medicine Mayo Clinic Rochester, Minnesota.

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February 2019

Diagnostic and Treatment Implications of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.

Gastroenterol Hepatol (N Y) 2019 Feb;15(2):83-89

Dr Terrence Wong is a resident physician in the Department of Medicine in the Division of Gastroenterology and Hepatology at Alameda Health System-Highland Hospital in Oakland, California.

Nonalcoholic fatty liver disease (NAFLD) affects 75 to 100 million adults in the United States and is the leading cause of chronic liver disease worldwide, fueled by the rising epidemic of obesity and metabolic syndrome. NAFLD is the hepatic manifestation of metabolic syndrome; thus, accurately assessing and managing comorbid metabolic syndrome components is paramount. Nonalcoholic steatohepatitis (NASH) is a subset of NAFLD that includes a more progressive and advanced form of the disease, with a greater risk of fibrosis progression. Read More

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February 2019
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Antineoplastic therapy side effects and polypharmacy in older adults with cancer.

Top Geriatr Rehabil 2019 Jan-Mar;35(1):15-30

Oncology Consultants, Houston, Texas.

The geriatric oncology population requires special consideration in rehabilitation care planning due to drug side effects and potential drug interactions that occur with cancer treatment. Antineoplastic therapies incite side effects that are frequently managed with additional pharmacological interventions, often resulting in a cascade of drug side effects. Moreover, this population is disproportionately affected by multiple pre-existing co-morbidities that require the use of multiple medications. Read More

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http://dx.doi.org/10.1097/TGR.0000000000000212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474376PMC
January 2020

Cost Comparison of an On-Premise IT Solution with a Cloud-Based Solution for Electronic Health Records in a Dental School Clinic.

J Dent Educ 2019 Apr 22. Epub 2019 Apr 22.

Lynn Johnson is Professor and Associate Dean, University of Michigan School of Dentistry; Cassandra Callaghan is Director of Dental Informatics, University of Michigan School of Dentistry; Madhan Balasubramanian is Sidney Sax National Health and Medical Research Council Research Fellow, University of Sydney, Australia and King's College London, United Kingdom; Haris Haq is a Consultant, Collaboration for Health IT; and Heiko Spallek is Professor, Head of School, and Dean, The University of Sydney School of Dentistry, Sydney, New South Wales, Australia.

Electronic health records (EHRs) are increasingly moving towards cloud-based web environments. While cloud-based EHRs claim substantial benefits at reduced cost, little cost-benefit research exists for dental schools. The aim of this study was to examine the cost-benefits of a cloud-based EHR compared to an on-premise client-server EHR in the University of Michigan School of Dentistry (U-M Dent). Read More

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http://dx.doi.org/10.21815/JDE.019.089DOI Listing

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Viruses 2019 Apr 20;11(4). Epub 2019 Apr 20.

Department of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.

Parvoviruses, infecting vertebrates and invertebrates, are a family of single-stranded DNA viruses with small, non-enveloped capsids with T = 1 icosahedral symmetry. A quarter of a century after the first parvovirus capsid structure was published, approximately 100 additional structures have been analyzed. This first structure was that of Canine Parvovirus, and it initiated the practice of structure-to-function correlation for the family. Read More

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https://www.mdpi.com/1999-4915/11/4/362
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http://dx.doi.org/10.3390/v11040362DOI Listing
April 2019
1 Read

The SITS-UTMOST: A registry-based prospective study in Europe investigating the impact of regulatory approval of intravenous Actilyse in the extended time window (3-4.5 h) in acute ischaemic stroke.

Eur Stroke J 2016 Sep 29;1(3):213-221. Epub 2016 Jul 29.

Department of Clinical Neuroscience, Karolinska Institutet and Department of Neurology Karolinska University Hospital, Stockholm, Sweden.

Introduction: The SITS-UTMOST (Safe Implementation of Thrombolysis in Upper Time window Monitoring Study) was a registry-based prospective study of intravenous alteplase used in the extended time window (3-4.5 h) in acute ischaemic stroke to evaluate the impact of the approval of the extended time window on routine clinical practice.

Patients And Methods: Inclusion of at least 1000 patients treated within 3-4. Read More

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http://dx.doi.org/10.1177/2396987316661890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301239PMC
September 2016

Pediatric Boot Camp Series: Obtaining a Consult, Discussing Difficult News.

MedEdPORTAL 2016 Aug 12;12:10437. Epub 2016 Aug 12.

Associate Professor in Pediatrics and Medical Education, Northwestern University Feinberg School of Medicine.

Introduction: Transitioning from medical student to intern requires individuals to possess medical knowledge, clinical skills, and the ability to communicate with a wide variety of health care professional as well as patients and their families. New doctors may be expected to function within the health care team without having received explicit instruction in communication previously. The materials associated with this publication are intended to be used as resources for small-group education of graduating medical students entering into pediatric, family medicine, or emergency medicine residencies. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464432PMC

Sex, Bugs, and Rock 'n' Roll: A Service-Learning Innovation to Enhance Medical Student Knowledge and Comfort With Sexual Health.

MedEdPORTAL 2016 Jun 24;12:10421. Epub 2016 Jun 24.

Team Facilitator, Business Development Unit, Canterbury District Health Board, Christchurch, New Zealand.

Introduction: Sexual health is an intrinsic element of overall health; however, opportunities to enhance medical student comfort and knowledge about sexual health vary substantially and receive limited curricular time. Sex, Bugs, and Rock 'n' Roll is a novel service-learning initiative designed to enhance undergraduate medical student knowledge and comfort with sexual health. A total of 80 fifth-year undergraduate medical students researched, designed, and delivered a short sexual health promotion initiative for a population that experiences inequity. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464422PMC

Interdisciplinary Workshop to Increase Collaboration Between Medical Students and Standardized Patient Instructors in Teaching Physical Diagnosis to Novices.

MedEdPORTAL 2016 Jun 10;12:10411. Epub 2016 Jun 10.

Clinical Professor, George Washington University School of Medicine and Health Sciences.

Introduction: Traditionally, full-time faculty members have assumed major responsibility for teaching physical examination skills to first- and second-year medical students. Problems with faculty recruitment and adhering to a standardized way of teaching have challenged educators to seek alternatives to teaching the physical examination to novices. To address these problems, we created and implemented a novel curriculum that has standardized the teaching of physical examination skills to novice students by using standardized patient instructors (SPIs) and fourth-year medical students (MS-4s) working as an interdisciplinary team (known as a dyad). Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464468PMC

Prostate Leiomyosarcoma: a rare misleading tumour.

Urology 2019 Apr 19. Epub 2019 Apr 19.

Urology Consultant, Hospital Beatriz Ângelo. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2019.04.014DOI Listing

Modified GoPro Hero 6 and 7 for Intraoperative Surgical Recording-Transformation Into a Surgeon-Perspective Professional Quality Recording System.

J Oral Maxillofac Surg 2019 Mar 27. Epub 2019 Mar 27.

Chief, Division of Head and Neck Surgery; Program Director, Head and Neck Oncologic Surgery and Microvascular Fellowship; Associate Department Chair and Professor, Department of Oral and Maxillofacial Surgery, University of Florida College of Medicine-Jacksonville, Jacksonville, FL.

Recent innovations in wearable action cameras with high-definition video recording enable surgeons to use cameras for their surgical procedures. In this study, the GoPro HERO 6 (and 7) Black edition camera was modified step by step to allow for a completely wireless surgeon-perspective recording with a battery life and memory capacity never previously obtained with such a high level of digital video quality. With this system, a surgeon can record for more than 14 hours 26 minutes in 1,080 pixels at 60 frames per second without breaking scrub and capture the operating surgeon's direct view of the field. Read More

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http://dx.doi.org/10.1016/j.joms.2019.03.026DOI Listing

Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats.

PLoS Comput Biol 2019 Apr 22;15(4):e1006838. Epub 2019 Apr 22.

Department of Psychiatry, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, United States of America.

The ventral striatum (VS) is a central node within a distributed network that controls appetitive behavior, and neuromodulation of the VS has demonstrated therapeutic potential for appetitive disorders. Local field potential (LFP) oscillations recorded from deep brain stimulation (DBS) electrodes within the VS are a pragmatic source of neural systems-level information about appetitive behavior that could be used in responsive neuromodulation systems. Here, we recorded LFPs from the bilateral nucleus accumbens core and shell (subregions of the VS) during limited access to palatable food across varying conditions of hunger and food palatability in male rats. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006838DOI Listing

It's how we communicate! Exploring face-to-face versus electronic communication networks in multidisciplinary teams.

Health Care Manage Rev 2019 Apr 17. Epub 2019 Apr 17.

Daniele Mascia, PhD, is Associate Professor, Department of Management, University of Bologna, Italy. E-mail: Emanuele Rinninella, MD, is Hepatocatt Team Clinical Coordinator and Consultant Physician, Department of Internal Medicine and Gastroenterology, Fondazione Policlinico "A. Gemelli" IRCCS Research Hospital, Rome, Italy, and Università Cattolica del Sacro Cuore, Rome, Italy. Nicola Walter Pennacchio, MPH, MA, is Research Fellow, Graduate School of Health Economics and Management, Università Cattolica Sacro Cuore, Rome, Italy. Lucia Cerrito, MD, is Hepatocatt Team Coordinator and Fellow in Internal Medicine, Department of Internal Medicine and Gastroenterology, Fondazione Policlinico "A. Gemelli" IRCCS Research Hospital, Rome, Italy, and Università Cattolica del Sacro Cuore, Rome, Italy. Antonio Gasbarrini, MD, PhD, is Full Professor, Department of Internal Medicine and Gastroenterology, Fondazione Policlinico "A. Gemelli" IRCCS Research Hospital, Rome, Italy, and Faculty of Medicine and Surgery, Università Cattolica Sacro Cuore, Rome, Italy.

Background: Previous research suggests that multidisciplinary team communication networks enhance knowledge exchange, learning, and quality of care in health organizations. However, little is known about team members' reliance on face-to-face versus electronic-based communication networks for information and knowledge exchange.

Purpose: The aim of the study was to describe patterns of face-to-face versus electronic-based communication networks in a multidisciplinary team and to explore the relationships between team communication networks and performance, measured as promptness of treatment implementation. Read More

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http://dx.doi.org/10.1097/HMR.0000000000000246DOI Listing

Hot Tubbing with the Coroner, 2018.

Med Leg J 2019 Apr 22:25817219830257. Epub 2019 Apr 22.

5 Emeritus Professor of Colorectal Surgery, Birmingham University, UK.

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http://dx.doi.org/10.1177/0025817219830257DOI Listing

Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries.

Ann N Y Acad Sci 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatrics, Emory University, Atlanta, Georgia.

Anemia affects a third of the world's population and contributes to increased morbidity and mortality, decreased work productivity, and impaired neurological development. Understanding anemia's varied and complex etiology is crucial for developing effective interventions that address the context-specific causes of anemia and for monitoring anemia control programs. We outline definitions and classifications of anemia, describe the biological mechanisms through which anemia develops, and review the variety of conditions that contribute to anemia development. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/nyas.14092
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http://dx.doi.org/10.1111/nyas.14092DOI Listing
April 2019
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Longitudinal studies of ageing: from insights to impacts: commentary to accompany themed collection on longitudinal studies.

Age Ageing 2019 Apr 22. Epub 2019 Apr 22.

Associate Professor in Medical Gerontology, Trinity College Dublin and Consultant Physician, St James's Hospital, Dublin.

'Time is the best diagnostician': who has not thought this? In clinical practice, presentations are often subtle and decisions made in the face of a 'snapshot.' Crystal balls do not exist; yet, insights from longitudinal studies can help to recognise emerging pictures and anticipate typical trajectories. In the multifactorial, biopsychosocial world of geriatrics, the determinants of those trajectories, and hence opportunities to modify them, can be better understood through careful longitudinal disentangling of the wider determinants of health, and this can be done at multiple levels of analysis, from molecules to society. Read More

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https://academic.oup.com/ageing/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/ageing/afz028DOI Listing
April 2019
1 Read

Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment.

Chronic Stress (Thousand Oaks) 2019 Jan-Feb;3. Epub 2019 Apr 15.

Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas.

Background: In soldiers with posttraumatic stress disorder (PTSD), symptom provocation was found to induce increased connectivity within the salience network, as measured by functional magnetic resonance imaging (MRI) and global brain connectivity with global signal regression (GBCr). However, it is unknown whether these GBCr disturbances would normalize following effective PTSD treatment.

Methods: 69 US Army soldiers with (n = 42) and without PTSD (n = 27) completed MRI at rest and during symptom provocation using subject-specific script imagery. Read More

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http://dx.doi.org/10.1177/2470547019838971DOI Listing

Reflections on and discussions about 'Luminous Life: A New Model of Humanistic Psychotherapy'.

Open J Psychiatry Allied Sci 2019 Jan-Jun;10(1):87-90. Epub 2019 Jan 16.

Consultant Psychiatrist General Adults, Lancashire care NHS Foundation Trust, UK.

This paper is an attempt to introduce a new approach in Humanistic Psychotherapy. It grew out of a psychiatry consultant's years of work in individual psychotherapy with the patients and got published in a self-help format. Later a clinical psychology consultant read the book and reflected in detail on it. Read More

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http://dx.doi.org/10.5958/2394-2061.2019.00015.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474410PMC
January 2019

Risk-based monitoring: Review of the current perceptions and toward effective implementation.

Perspect Clin Res 2019 Apr-Jun;10(2):57-61

CEO, Medicines n We, Clinical Research and Healthcare Consultant, Mumbai, Maharashtra, India.

The United States Food and Drug Administration issued a guidance to industry in August 2013 on risk-based approach to monitoring. This prompted industry (sponsors and contract research organizations) to brainstorm, conceptualize, and implement risk-based monitoring (RBM) in their clinical studies and programs. The acceptance and implementation across the organizations have been variable in terms of pace and methodology. Read More

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http://dx.doi.org/10.4103/picr.PICR_18_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463506PMC

Conducting real-world evidence studies in India.

Authors:
Arun Bhatt

Perspect Clin Res 2019 Apr-Jun;10(2):51-56

Consultant - Clinical Research and Development, Mumbai, Maharashtra, India.

Real-world data (RWD) are data relating to patients' health status and/or the delivery of health care routinely collected from a variety of sources. Real-world evidence (RWE) is the clinical evidence regarding the usage and potential benefits or risks of a medical product derived from analysis of RWD. RWE can provide information on diverse areas, for example, natural history and course of disease, effectiveness studies, outcome research, and safety surveillance. Read More

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http://dx.doi.org/10.4103/picr.PICR_8_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463503PMC

Clinical and Radiological Outcomes of Oblique Lateral Lumbar Interbody Fusion.

Cureus 2019 Feb 7;11(2):e4029. Epub 2019 Feb 7.

Neurosurgery, Inspired Spine Health, Minneapolis, USA.

Oblique lateral lumbar interbody fusion (OLLIF) is a novel operation for fusions of the lumbar spine from T12-S1. In OLLIF, the disk is approached from an oblique lateral angle guided by electrophysiological monitoring and biplanar fluoroscopy; the disk space is accessed through Kambin's triangle. We present perioperative, clinical, patient-reported and radiological outcomes from a series of 303 OLLIF procedures on 568 levels performed by the same surgeon. Read More

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https://www.cureus.com/articles/17137-clinical-and-radiologi
Publisher Site
http://dx.doi.org/10.7759/cureus.4029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453614PMC
February 2019
1 Read

Skin microdialysis: methods, applications and future opportunities-an EAACI position paper.

Clin Transl Allergy 2019 10;9:24. Epub 2019 Apr 10.

3Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Read More

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http://dx.doi.org/10.1186/s13601-019-0262-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456961PMC

Our Experience in the Management of Vaginal Agenesis: Its Psychosocial Impact and Role of Contrast Magnetic Resonance Imaging Scan with Vaginal Mold in the Interpretation of High Transverse Vaginal Septum.

J Hum Reprod Sci 2019 Jan-Mar;12(1):67-71

Assistant Prof. Obstetrics & Gynecology, Terna Medical College, Nerul, Navi Mumbai, Maharashtra, India.

Background: Mullerian anomalies are of many types, and it is very difficult to classify them in a simple method and plan reconstructive surgery. The aims, objective and the reconstructive surgical approach varies according to the level of vaginal agenesis as seen in our experience of management of 11 cases. The difficulties in the perception and interpretation of the surgical anatomy on magnetic resonance imaging can be minimized by placing a soft vaginal mold inside the lower developed vaginal segment in cases with transverse vaginal septum. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_82_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472209PMC

Personalized Embryo Transfer Helps in Improving Fertilization/ICSI Outcomes in Patients with Recurrent Implantation Failure.

J Hum Reprod Sci 2019 Jan-Mar;12(1):59-66

Director, Nova IVI Fertility, Navrangpura, Ahmedabad, Gujarat, India.

Aims: This study aims to compare clinical outcomes in patients of recurrent implantation failure (RIF), who had embryo transfer (ET) following a receptive (R) endometrial receptivity array (ERA) and a personalized embryo transfer (pET) after a nonreceptive (NR) ERA.

Settings And Design: This was a retrospective observational study.

Study Period: July 2013-September 2017. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_74_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472200PMC

Anxiety and Stress at Different Stages of Treatment in Women Undergoing Fertilization-Intracytoplasmic Sperm Injection.

J Hum Reprod Sci 2019 Jan-Mar;12(1):47-52

Senior Consultant, Nova IVI Fertility, Ahmedabad, Gujarat, India.

Aim: The aim of the present study is to evaluate the state anxiety (the present state of mind), trait anxiety (general anxiety), as well as perceived stress in women undergoing fertilization (IVF) treatment at three stages: T1 (on the day of start of stimulation), T2 (on the day of embryo transfer), and T3 (10 days after embryo transfer). The data at T3 level were collected telephonically.

Methodology: The present study was carried out on 137 women undergoing IVF intracytoplasmic sperm injection cycle at four different clinics of four cities from October to April 2016. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_23_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472199PMC

Mimickers of Amyotrophic Lateral Sclerosis.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):252-253

Department of Neurology, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, Tamil Nadu, India.

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http://dx.doi.org/10.4103/aian.AIAN_452_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472250PMC

Expert Group Meeting on Aphasia: A Report.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):137-146

Aphasia Research Center, Maryland, USA.

A multidisciplinary team of experts took stock of the current state of affairs about many aspects of aphasia in India, including community burden, diagnostic assessment, therapy, rehabilitation, research, education, and advocacy. The broad spectrum of aphasiology was matched by the types of participants ranging from neurologists, speech-language pathologists, clinical psychologists, linguists, to experts in neuroimaging and computer sciences. Threadbare discussion in 16 sessions over 3 days leads to the identification of pressing problems and possible solutions. Read More

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http://dx.doi.org/10.4103/aian.AIAN_330_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472241PMC

Assessing the environmental impacts of EU consumption at macro-scale.

J Clean Prod 2019 Apr;216:382-393

European Commission, Joint Research Centre, Via Enrico Fermi 2749, I-21027 Ispra, VA, Italy.

Sustainable Consumption and Production is one of the leading principle towards reducing environmental impacts globally. This study aims at combining Environmentally-Extended Input-Output Analysis (using EXIOBASE 3) with up-to-date impact assessment models to quantify the environmental impacts induced by final consumption in the EU Member States in 2011. The environmental extensions are characterized in 14 environmental impact categories out of the 16 used in the Environmental Footprint life cycle impact assessment method. Read More

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http://dx.doi.org/10.1016/j.jclepro.2019.01.134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472615PMC

Gender-based constraints affecting biofortified cassava production, processing and marketing among men and women adopters in Oyo and Benue States, Nigeria.

Physiol Mol Plant Pathol 2019 Jan;105:17-27

International Institute of Tropical Agriculture (IITA), Ibadan, Nigeria.

This study identified gender-based constraints affecting the production, processing and marketing of biofortified cassava in two states in Nigeria, using a mixed methods approach. The study identified major differences between the two study sites (Benue and Oyo). The scale of production of biofortified cassava is higher in Oyo state among adult men because of their active involvement and collaboration with research institutes within the state and the ease of transporting products to Lagos State for designated diverse markets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08855765183004
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http://dx.doi.org/10.1016/j.pmpp.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472612PMC
January 2019
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Commentary: Adjunctive agents in peribulbar anesthesia: Role of dexmedetomidine in vitreo-retinal surgeries.

Authors:
Sahil Bhandari

Indian J Ophthalmol 2019 May;67(5):642-643

Consultant Ophthalmologist and Vitreo-Retinal Surgeon, Guru Hasti Chikitsalya, Jodhpur, Rajasthan, India.

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http://dx.doi.org/10.4103/ijo.IJO_176_19DOI Listing

Experience with telepathology in combination with diagnostic assistance systems in countries with restricted resources.

J Telemed Telecare 2019 Apr 21:1357633X19840475. Epub 2019 Apr 21.

3 IPath Telemedicine Network gemeinnützige GmbH, Aurich, Germany.

Introduction: We describe the use of telepathology in countries with restricted resources using two diagnosis assistance systems (Isabel and Memem7) in addition to the diagnoses made by experts in pathology via the iPath-Network.

Methods: A total of 156 cases, largely from Afghanistan, were analysed; 18 cases had to be excluded because of poor image quality.

Results: Of the remaining 138 cases (100%), a responsible physician provided a tentative diagnosis for 61. Read More

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http://journals.sagepub.com/doi/10.1177/1357633X19840475
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http://dx.doi.org/10.1177/1357633X19840475DOI Listing
April 2019
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Strategies for Overcoming Barriers to Adopting Biosimilars and Achieving Goals of the Biologics Price Competition and Innovation Act: A Survey of Managed Care and Specialty Pharmacy Professionals.

J Manag Care Spec Pharm 2019 Apr 22:1-9. Epub 2019 Apr 22.

3 Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Background: The Biologics Price Competition and Innovation Act (BPCIA) of 2009, which included pathways for FDA approval of biosimilar products, was designed to promote more affordable, expanded patient access to biologic therapies. Achieving these BPCIA goals depends on overcoming formidable barriers to biosimilar adoption. Managed care and specialty pharmacy professionals are uniquely qualified to inform initiatives to address these barriers. Read More

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https://www.jmcp.org/doi/10.18553/jmcp.2019.18412
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http://dx.doi.org/10.18553/jmcp.2019.18412DOI Listing
April 2019
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Mind the Gap: Spanning the Great Divide Between Perceived and Measured Value of Infectious Disease Physicians.

J Pediatric Infect Dis Soc 2019 Apr 22. Epub 2019 Apr 22.

Stanford Children's Health, Stanford University School of Medicine, California.

The pediatric infectious disease community has struggled to identify metrics that demonstrate the value that we add to the care of our patients. This challenge is largely a function of our typical role as a consultant in most healthcare settings. Most current quality metrics, however, are designed to measure patient outcomes that are directly affected by the primary clinical team, not the consultants they seek to involve. Read More

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http://dx.doi.org/10.1093/jpids/piz020DOI Listing

The culture, mental health and psychosocial wellbeing of Rohingya refugees: a systematic review.

Epidemiol Psychiatr Sci 2019 Apr 22:1-6. Epub 2019 Apr 22.

Public Health Section, United Nations High Commissioner for Refugees,Geneva,Switzerland.

AimsDespite the magnitude and protracted nature of the Rohingya refugee situation, there is limited information on the culture, mental health and psychosocial wellbeing of this group. This paper, drawing on a report commissioned by the United Nations High Commissioner for Refugees (UNHCR), aims to provide a comprehensive synthesis of the literature on mental health and psychosocial wellbeing of Rohingya refugees, including an examination of associated cultural factors. The ultimate objective is to assist humanitarian actors and agencies in providing culturally relevant Mental Health and Psychosocial Support (MHPSS) for Rohingya refugees displaced to Bangladesh and other neighbouring countries. Read More

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http://dx.doi.org/10.1017/S2045796019000192DOI Listing
April 2019
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