50,855 results match your criteria Consultant For Pediatricians [Journal]


2018 Infectious Diseases Society of America Clinical Practice Guideline for the Management of Outpatient Parenteral Antimicrobial Therapy.

Clin Infect Dis 2019 Jan;68(1):1-4

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, and Center for Evidence-based Practice, University of Pennsylvania Health System, Philadelphia.

A panel of experts was convened by the Infectious Diseases Society of America to update the 2004 clinical practice guideline on outpatient parenteral antimicrobial therapy (OPAT) [1]. This guideline is intended to provide insight for healthcare professionals who prescribe and oversee the provision of OPAT. It considers various patient features, infusion catheter issues, monitoring questions, and antimicrobial stewardship concerns. Read More

View Article
January 2019

Arterial and pulmonary hypertension: risk assessment and current pharmacological and interventional management.

Eur Heart J 2018 Dec;39(47):4127-4131

Imperial College and Consultant and Director of Research, Education & Development, Royal Brompton and Harefield Hospital Trust, London, UK.

View Article
December 2018

NEW PROPOSAL FOR THE PATHOPHYSIOLOGY OF TYPE 3 NEOVASCULARIZATION AS BASED ON MULTIMODAL IMAGING FINDINGS.

Authors:
Richard F Spaide

Retina 2018 Dec 6. Epub 2018 Dec 6.

Vitreous, Retina, Macula Consultants of New York, New York.

Purpose: To investigate the imaging characteristics of early Type 3 neovascularization and propose a new pathophysiologic sequence for early disease.

Methods: Patients were evaluated with a comprehensive ophthalmologic examination to include fundus photography, optical coherence tomography, optical coherence tomography angiography, fluorescein angiography, and volume-rendered optical coherence tomography angiography. Relevant literature was also reviewed. Read More

View Article
December 2018

Aggressive subcutaneous trichoblastomas successfully treated with Mohs micrographic surgery.

Australas J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Advocate Illinois Masonic Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

View Article
December 2018

Sharpening the focus on ophthalmology teaching: has anything changed?

Authors:
Catherine Green

Clin Exp Ophthalmol 2018 Dec;46(9):981-983

Royal Australian and New Zealand College of Ophthalmologists, Sydney, New South Wales, Australia.

View Article
December 2018
1 Read

Willingness to Change Medications Linked to Increased Fall Risk: A Comparison between Age Groups.

J Am Geriatr Soc 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington.

Objective: To describe and compare two age groups' knowledge of medications linked to falls and willingness to change these medications to reduce their fall risk.

Method: We analyzed data from community-dwelling adults age 55 and older (n = 1812): 855 adults aged 55 to 64 years and 957 older adults (65 and older) who participated in the 2016 summer wave of the ConsumerStyles survey, an annual Web-based survey. The data are weighted to match the US Current Population Survey proportions on nine US Census Bureau demographic characteristics. Read More

View Article
December 2018

Compendium of the Health and Wellness Coaching Literature.

Am J Lifestyle Med 2018 Nov-Dec;12(6):436-447. Epub 2017 May 19.

Department of Exercise & Sport Sciences, Ithaca College, Ithaca, New York (GAS, SH, KC, LC).

Health and wellness coaching (HWC) for lifestyle behavior change is emerging as a practice, role, and profession, in diverse health care, employee wellness, and community settings. Health care professionals apply HWC as a behavior change methodology for the prevention and treatment of diabetes, hypertension, hyperlipidemia, heart disease, cancer, and other chronic disorders. The purpose of this systematic review was to provide a comprehensive and organized compendium of HWC literature. Read More

View Article

Sources of Mercury Exposure to Children in Low- and Middle-Income Countries.

J Health Pollut 2015 Jun 2;5(8):33-51. Epub 2015 Jul 2.

Civil and Environmental Engineering, Department, U.C.L.A., Los Angeles, CA, U.S.A.

Background: Many children in low- and middle-income countries face enhanced risks of exposure to contaminants via the environment, parental occupation, and other routes. While mercury (Hg) is a global pollutant whose transport properties allow it to have an impact even in pristine areas, the presence of significant Hg sources in the developing world can cause localized effects that are more severe than those observed in other areas.

Objectives: This paper provides a narrative review of sources of Hg exposure to people in the developing world with a particular focus on children, and presents an overview of key aspects to this important issue. Read More

View Article

Point of Care Echocardiography in an Irish Critical Care Unit

Ir Med J 2018 09 10;111(8):800. Epub 2018 Sep 10.

Consultant Intensivist, Mater Misercordiae University Hospital, Eccles Street, Dublin 7, Ireland

Aims We sought to evaluate the clinical impact of a 6 month transthoracic echocardiography (TTE) teaching programme in a critical care unit. Methods An observational single centre study. Four critical care doctors, 2 fellows and 2 consultants were trained to use TTE. Read More

View Article
September 2018
1 Read

Investigating the Association Between Baseline Characteristics (HbA1c and Body Mass Index) and Clinical Outcomes of Fast-Acting Insulin Aspart in People with Diabetes: A Post Hoc Analysis.

Diabetes Ther 2018 Dec 13. Epub 2018 Dec 13.

Clinical and Experimental Endocrinology, University Hospital Leuven, Catholic University of Leuven, Leuven, Belgium.

Introduction: The aim of this study was to investigate the association between baseline characteristics [HbA1c and body mass index (BMI)] and the effect of mealtime fast-acting insulin aspart (faster aspart) relative to insulin aspart (IAsp) or basal-only insulin therapy on several efficacy and safety outcomes in people with diabetes.

Methods: Post hoc analysis of three randomised phase 3a trials in people with type 1 diabetes (T1D; onset 1) and type 2 diabetes (T2D; onset 2 and 3). Participants (N = 1686) were stratified according to baseline BMI (< 25 kg/m, 25-< 30 kg/m, ≥ 30 kg/m) or HbA1c (≤ 58 mmol/mol, > 58-< 64 mmol/mol, ≥ 64 mmol/mol; ≤ 7. Read More

View Article
December 2018
1 Read

Robotic versus freehand S2 alar iliac fixation: in-depth technical considerations.

J Spine Surg 2018 Sep;4(3):638-644

Department of Orthopedic Surgery, Norton Leatherman Spine Center, Louisville, KY, USA.

Achieving fixation and fusion across the lumbosacral junction has been a challenge for spinal deformity surgeons ever since the development of instrumentation. The S2 alar-iliac (S2AI) trajectory has been introduced as a method of pelvic fixation to decrease strain on S1 screws. The S2AI screws differ in several ways from traditional iliac screws. Read More

View Article
September 2018

Early term effects of rhBMP-2 on pedicle screw fixation in a sheep model: histomorphometric and biomechanical analyses.

J Spine Surg 2018 Sep;4(3):534-545

Orthopaedic & Rehabilitation Engineering Center and Graduate Program in Dental Biomaterials, Marquette University, Milwaukee, WI, USA.

Background: The effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pedicle screw pullout force and its potential to improve spinal fixation have not previously been investigated. rhBMP-2 on an absorbable collagen sponge (ACS) carrier was delivered in and around cannulated and fenestrated pedicle screws in a sheep lumbar spine instability model. Two control groups (empty screw and ACS with buffer) were also evaluated. Read More

View Article
September 2018

Do Tibial Eminence Fractures and Anterior Cruciate Ligament Tears Have Similar Outcomes?

Orthop J Sports Med 2018 Dec 7;6(12):2325967118811854. Epub 2018 Dec 7.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Avulsion fractures involving the tibial eminence are considered equivalent in terms of the cause to anterior cruciate ligament (ACL) tears; however, there are limited data comparing the outcomes of adolescent patients undergoing surgical fixation of a tibial eminence fracture (TEF) with those undergoing ACL reconstruction.

Purpose: To compare the clinical outcomes, subsequent ACL injury rates, and activity levels between adolescent patients who underwent TEF fixation with patients with midsubstance ACL tears who required acute reconstruction.

Study Design: Cohort study; Level of evidence, 3. Read More

View Article
December 2018

Foreign Body Reaction Associated With Artificial LARS Ligaments: A Retrieval Study.

Orthop J Sports Med 2018 Dec 4;6(12):2325967118811604. Epub 2018 Dec 4.

St John of God Hospital, Subiaco, Perth, Australia.

Background: Artificial ligaments have been developed and used in the treatment of ligamentous injuries since the 1970s. The early generation of artificial ligaments showed promising short-term results but resulted in high rates of rupture and inflammatory reaction in the surrounding tissues.

Purpose: To determine whether the use of Ligament Augmentation and Reconstruction System (LARS) ligaments is associated with the development of intra-articular foreign body reaction. Read More

View Article
December 2018

Axillary Nerve Position in Humeral Avulsions of the Glenohumeral Ligament.

Orthop J Sports Med 2018 Dec 5;6(12):2325967118811044. Epub 2018 Dec 5.

Department of Mathematics and Statistics, Faculty of Science and Engineering, Macquarie University, Sydney, Australia.

Background: The axillary nerve is at risk during repair of a humeral avulsion of the glenohumeral ligament (HAGL).

Purpose: To measure the distance between the axillary nerve and the free edge of a HAGL lesion on preoperative magnetic resonance imaging (MRI) and compare these findings to the actual intraoperative distance measured during open HAGL repair.

Study Design: Case series; Level of evidence, 4. Read More

View Article
December 2018

Declining Condom Use Among Sex Workers in Western Australia.

Front Public Health 2018 27;6:342. Epub 2018 Nov 27.

Collaboration for Evidence, Research and Impact in Public Health, School of Public Health, Curtin University, Bentley, WA, Australia.

Since the emergence of the HIV pandemic in the 1980s, high rates of condom use for penetrative sex have been reported among sex workers in Australia. The sex industry in Australia and elsewhere has changed over the previous decade with increasing proportions of sex workers working privately and lower proportions of sex workers working in brothels. There has also been some evidence of reductions in condom use, particularly during penetrative oral sex. Read More

View Article
November 2018

Psychiatric outcomes observed in patients living with HIV using six common core antiretrovirals in the Observational Pharmaco-Epidemiology Research and Analysis database.

Ther Adv Drug Saf 2018 Dec 29;9(12):675-686. Epub 2018 Oct 29.

Epividian, Inc., Durham, NC, USA.

Background: Psychiatric outcomes are common among people living with HIV and may be associated with specific antiretroviral use. We evaluated the occurrence of psychiatric outcomes in patients taking dolutegravir (DTG)-containing regimens compared with five other core agents.

Methods: Patients in the OPERA database prescribed regimens based on DTG, efavirenz (EFV), raltegravir (RAL), darunavir (DRV), rilpivirine (RPV), or elvitegravir (EVG) for the first time between 1 January 2013 and 31 December 2015 were analyzed. Read More

View Article
December 2018

Attention-Deficit Hyperactivity Disorder (ADHD) and narrative discourse in older adults.

Dement Neuropsychol 2018 Oct-Dec;12(4):374-379

The Hospital for Sick Children (SickKids), Toronto, ON, Canada.

Attention-Deficit Hyperactivity Disorder (ADHD) encompasses other symptoms besides inattention, hyperactivity, and impulsivity, such as language problems. ADHD can have a non-remitting course and is also found in older individuals, although there are no studies on language problems in elderly individuals with the disorder.

Objective: To investigate the presence of language impairment in older adults with ADHD. Read More

View Article
December 2018

Retinal burns from laser pointers: a risk in children with behavioural problems.

Eye (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Bolton Hospitals NHS Foundation Trust, Bolton, UK.

Objective: To explore self-inflicted retinal burns from laser pointers in children.

Methods: Literature review of laser pointer retinal injuries in childhood and online survey of UK Consultant Ophthalmologists. A cohort of local children with self-inflicted injury is described. Read More

View Article
December 2018

Pulmonary hypertension in chronic lung disease and hypoxia.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig University Giessen and Member of the German Center for Lung Research (DZL), Giessen, Germany.

Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Read More

View Article
December 2018

Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Center for Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Paediatric pulmonary arterial hypertension (PAH) shares common features of adult disease, but is associated with several additional disorders and challenges that require unique approaches. This article discusses recent advances, ongoing challenges and distinct approaches for the care of children with PAH, as presented by the Paediatric Task Force of the 6th World Symposium on Pulmonary Hypertension. We provide updates of the current definition, epidemiology, classification, diagnostics and treatment of paediatric PAH, and identify critical knowledge gaps. Read More

View Article
December 2018

Clinical trial design and new therapies for pulmonary arterial hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

San Diego School of Medicine, University of California, La Jolla, CA, USA.

Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on case reports and small series, and was largely ineffectual. As a deeper understanding of the pathogenesis and pathophysiology of PAH evolved over the subsequent two decades, coupled with epidemiological studies defining the clinical and demographic characteristics of the condition, a renewed interest in treatment development emerged through collaborations between international experts, industry and regulatory agencies. These efforts led to the performance of robust, high-quality clinical trials of novel therapies that targeted putative pathogenic pathways, leading to the approval of more than 10 novel therapies that have beneficially impacted both the quality and duration of life. Read More

View Article
December 2018
1 Read

Genetics and genomics of pulmonary arterial hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Vanderbilt University Medical Center, Nashville, TN, USA.

Since 2000 there have been major advances in our understanding of the genetic and genomics of pulmonary arterial hypertension (PAH), although there remains much to discover. Based on existing knowledge, around 25-30% of patients diagnosed with idiopathic PAH have an underlying Mendelian genetic cause for their condition and should be classified as heritable PAH (HPAH). Here, we summarise the known genetic and genomic drivers of PAH, the insights these provide into pathobiology, and the opportunities afforded for development of novel therapeutic approaches. Read More

View Article
December 2018

Diagnosis of pulmonary hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Dept of Pulmonary Circulation and Cardidology, Medical Center for Postgraduate Education, ECZ-Otwock, Otwock, Poland.

A revised diagnostic algorithm provides guidelines for the diagnosis of patients with suspected pulmonary hypertension, both prior to and following referral to expert centres, and includes recommendations for expedited referral of high-risk or complicated patients and patients with confounding comorbidities. New recommendations for screening high-risk groups are given, and current diagnostic tools and emerging diagnostic technologies are reviewed. Read More

View Article
December 2018

Chronic thromboembolic pulmonary hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Royal Papworth Hospital, Cambridge, UK.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication of pulmonary embolism and a major cause of chronic PH leading to right heart failure and death. Lung ventilation/perfusion scintigraphy is the screening test of choice; a normal scan rules out CTEPH. In the case of an abnormal perfusion scan, a high-quality pulmonary angiogram is necessary to confirm and define the pulmonary vascular involvement and prior to making a treatment decision. Read More

View Article
December 2018
1 Read

Past and anticipated trends in cardiology service requirements at Mater Dei Hospital, Malta.

Early Hum Dev 2018 Dec 10. Epub 2018 Dec 10.

Mater Dei Hospital, Malta. Electronic address:

Introduction: The requirement for medical services fluctuates. This study was carried out in order to attempt to extrapolate the service requirements for various cardiology services at Mater Dei Hospital, Malta over the coming five years, based on service demands from previous years.

Methods: Past annual data was obtained from hospital records for various services (to 2017). Read More

View Article
December 2018

The macronutrients' interplay.

Authors:
M F Nassar

Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.

Professor of Pediatrics and Consultant of Pediatric Clinical Nutrition, Children`s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address:

View Article
November 2018

PEDro searching has improved over time: A comparison of search commands from two six-month periods three years apart.

Int J Med Inform 2019 Jan 26;121:1-9. Epub 2018 Oct 26.

School of Public Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Institute for Musculoskeletal Health, Sydney Local Health District, Sydney, NSW, Australia.

Background: In 2014-2015, the Physiotherapy Evidence Database (PEDro) was searched poorly by users; few search commands used sophisticated features and ∼20% contained errors. To improve the quality of PEDro searches, users now receive error messages when using incorrect search commands and have access to video tutorials.

Objectives: To determine whether search quality has improved since error messages and tutorials were implemented; and evaluate the content of PEDro searches. Read More

View Article
January 2019

Ancient Ancestry Informative Markers for Identifying Fine-Scale Ancient Population Structure in Eurasians.

Genes (Basel) 2018 Dec 12;9(12). Epub 2018 Dec 12.

Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK.

The rapid accumulation of ancient human genomes from various areas and time periods potentially enables the expansion of studies of biodiversity, biogeography, forensics, population history, and epidemiology into past populations. However, most ancient DNA (aDNA) data were generated through microarrays designed for modern-day populations, which are known to misrepresent the population structure. Past studies addressed these problems by using ancestry informative markers (AIMs). Read More

View Article
December 2018

Generation of A Mucor circinelloides Reporter Strain-A Promising New Tool to Study Antifungal Drug Efficacy and Mucormycosis.

Genes (Basel) 2018 Dec 7;9(12). Epub 2018 Dec 7.

Departamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.

Invasive fungal infections caused by Mucorales (mucormycosis) have increased worldwide. These life-threatening infections affect mainly, but not exclusively, immunocompromised patients, and are characterized by rapid progression, severe tissue damage and an unacceptably high rate of mortality. Still, little is known about this disease and its successful therapy. Read More

View Article
December 2018

Amniotic Tissue Modulation of Knee Pain-A Focus on Osteoarthritis.

J Knee Surg 2018 Dec 13. Epub 2018 Dec 13.

Cartilage Restoration Center, OrthoIndy Hospital, Greenwood, Indiana.

The use of intra-articular therapies as sources of growth factors, anti-inflammatory mediators, and medicinal signaling cells for osteoarthritis (OA) is rapidly evolving. Amnion, chorion, amniotic fluid, and the umbilical cord are distinct placental tissues that have been investigated for use in OA. Amniotic membrane (AM) synthesizes a variety of growth factors, cytokines, and vasoactive peptides that modulate inflammation. Read More

View Article
December 2018

Auditory stimulation improves motor function and caretaker burden in children with cerebral palsy- A randomized double blind study.

PLoS One 2018 13;13(12):e0208792. Epub 2018 Dec 13.

Meshi Children's Rehabilitation Center, Jerusalem, Israel.

Aim: To investigate the impact of auditory stimulation on motor function in children with cerebral palsy (CP) and disabling hypertonia.

Method: 9 matched pairs (age: 7y5m, SD 4y1m; 13 boys; gross-motor-functional-classification-scale: median 4; manual-ability-classification-system: median 4) were randomized to receive either auditory stimulation embedded in music (study, n = 9) or music alone (sham, control, n = 9) for at least 10 minutes 4 times a week for 4 weeks. Goal-Attainment-Scale, Care-and-Comfort-Hypertonicity-Questionnaire, Gross-Motor-Function-Measure and Quality-of-Upper-Extremity-Skills-Test (QUEST) were assessed before and 5 months following intervention. Read More

View Article
December 2018

Cutaneous squamous cell carcinoma: predictors of positive and close margins and outcomes of re-excision in Northland, New Zealand.

N Z Med J 2018 Dec 14;131(1487):23-29. Epub 2018 Dec 14.

Department of General Surgery, Whangarei Hospital, Northland; Consultant General and Colorectal Surgeon, Whangarei Hospital, Northland; Honorary Senior Lecturer, Department of Surgery, University of Auckland, Auckland.

Background: Non-melanoma skin cancer (NMSC) is the most commonly diagnosed and costly cancer in Australasia. Cutaneous squamous cell carcinoma (cSCC) accounts for approximately 25% of NMSC. A better understanding of predictors of close and positive margins following surgical excision will help guide treatment. Read More

View Article
December 2018

Evolution of the Abbreviated Injury Scale: 1990-2015.

Traffic Inj Prev 2018 Dec 13:1-5. Epub 2018 Dec 13.

c U. S. Army Research Laboratory , Weapons and Materials Research Directorate , Aberdeen Proving Ground , Maryland.

Objective: Although the Abbreviated Injury Scale (AIS) was initially developed in the mid-1960s for tracking injury in automotive and aircraft crashes, it has grown to become an internationally recognized scoring system for a variety of traumatic injuries. This shift in focus and advances in organized medical care, combined with feedback from field use and outcome analysis, have resulted in several AIS updates and revisions. This article demonstrates how AIS codes and severities have changed over the last 25 years and investigates the effects of those changes. Read More

View Article
December 2018

Drug Discovery for Kinetoplastid Diseases: Future Directions.

ACS Infect Dis 2018 Dec 13. Epub 2018 Dec 13.

Novartis Institute for Tropical Diseases (NITD) , 5300 Chiron Way , Emeryville , California 94608 , United States.

Kinetoplastid parasites have caused human disease for millennia. Significant achievements have been made toward developing new treatments for leishmaniasis (particularly on the Indian subcontinent) and for human African trypanosomiasis (HAT). Moreover, the sustained decrease in the incidence of HAT has made the prospect of elimination a tantalizing reality. Read More

View Article
December 2018

Targeting ELK1: a wELKome addition to the prostate cancer armamentarium.

AME Med J 2018 Oct 31;3. Epub 2018 Oct 31.

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center.

View Article
October 2018

Phase Ib/II single-arm trial evaluating the combination of everolimus, lapatinib and capecitabine for the treatment of HER2-positive breast cancer with brain metastases (TRIO-US B-09).

Ther Adv Med Oncol 2018 9;10:1758835918807339. Epub 2018 Nov 9.

University of California, Los Angeles, Los Angeles, CA, USA.

Background: Improving outcomes for patients with human epidermal growth factor 2-positive (HER2+) central nervous system (CNS) metastases remains an unmet clinical need. This trial evaluated a novel combination of everolimus, lapatinib and capecitabine for this disease.

Methods: Patients with trastuzumab-pretreated, HER2+ breast cancer brain metastasis without prior therapy with a mammalian target of rapamycin (mTOR) inhibitor were eligible. Read More

View Article
November 2018

Evaluation of pregnancy outcomes in patients with multiple sclerosis after fingolimod exposure.

Ther Adv Neurol Disord 2018 3;11:1756286418804760. Epub 2018 Nov 3.

Department of Neurology, St Josef Hospital, Ruhr University, Bochum, Germany.

Background And Methods: Limited data are available on the safety of fingolimod in pregnant women. We estimated the risk of adverse pregnancy outcomes in women with multiple sclerosis (MS) exposed to fingolimod either shortly before or during pregnancy in prospectively collected cases from clinical trials, observational studies, surveillance programs, and spontaneous reports.

Results: The prevalence of major malformations among live births does not appear to be significantly higher than those in the general population and the unexposed MS population. Read More

View Article
November 2018

Propensity-matched analysis of minimally invasive approach versus sternotomy for mitral valve surgery.

Heart 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiothoracic Surgery, Lancashire Cardiac Centre, Blackpool, UK.

Objective: The objective of this multicentre study was to compare short-term and midterm outcomes between sternotomy and minimally invasive approaches for mitral valve surgery.

Methods: Data for all mitral valve procedures with or without concomitant tricuspid atrial fibrillation surgery were analysed from three UK hospitals between January 2008 and December 2016. To account for selection bias between minimally invasive approach and sternotomy, one-to-one propensity score calliper matching without replacement was performed. Read More

View Article
December 2018

Relationship between plaque composition by virtual histology intravascular ultrasound and clinical outcomes after percutaneous coronary intervention in saphenous vein graft disease patients: study protocol of a prospective cohort study.

BMC Cardiovasc Disord 2018 Dec 12;18(1):233. Epub 2018 Dec 12.

Cardiovascular Institute, Tianjin Chest Hospital, No.261 Tai er zhuang Road, Jinnan District, Tianjin, 300222, People's Republic of China.

Background: Plaque composition and morphologic characteristics identified by virtual histology intravascular ultrasound (VH-IVUS) can determine plaques at increased risk of clinical events following percutaneous coronary intervention (PCI) among coronary artery disease (CAD) patients. However, there have been few studies to investigate the relationship between plaque composition of saphenous vein graft (SVG) by VH-IVUS and clinical outcomes in patients with saphenous vein graft disease (SVGD) undergoing PCI. The purpose of this study is to determine whether plaque components and characteristics by VH-IVUS can predict major adverse cardiac events (MACEs) among SVGD patients undergoing PCI. Read More

View Article
December 2018

Snap shot view on anaemia in Chronic Kidney Disease of uncertain aetiology.

Nephrology (Carlton) 2018 Dec 7. Epub 2018 Dec 7.

Transplant and Dialysis Unit, Teaching Hospital, Kandy, Sri Lanka.

Aim: Anaemia is a well-known complication of Chronic Kidney Disease (CKD) but there are no published studies on the pattern of anaemia in Chronic Kidney Disease of uncertain aetiology (CKDu). This study aims to find out the prevalence, causes and associations of anaemia in CKDu to identify any unique features which are different from already described Anaemia in CKD.

Method: All (119) biopsy-confirmed CKDu patients in two endemic clinics (Girandurukotte and Wilgamuwa) were selected as cases. Read More

View Article
December 2018

Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia.

Case Rep Hematol 2018 6;2018:6452843. Epub 2018 Nov 6.

Associate Consultant, Department of Hematooncology, Artemis Hospitals, Gurgaon, India.

Acute monoblastic leukemia (AMoL) is a rare hematopoietic neoplasm, and simultaneous occurrence of acute monoblastic leukemia with chronic lymphocytic leukemia is very rare and only a few cases have been reported in the literature. We here report a rare case of dual hematological malignancy in an 85-year-old male. The peripheral blood and bone marrow examination revealed dual population of atypical cells, comprising large cells with opened-up chromatin having monocytic appearance and small mature-appearing lymphocytes. Read More

View Article
November 2018
1 Read

Prevalence of Myopia among Children Attending Pediatrics Ophthalmology Clinic at Ohud Hospital, Medina, Saudi Arabia.

J Ophthalmol 2018 7;2018:3708409. Epub 2018 Nov 7.

MD, FRCSEdn, Consultant Pediatric Ophthalmologist, RTPD Ophthalmology Program, Ohud Hospital, Madina, Saudi Arabia.

Introduction: Around half of the visually impaired population has uncorrected refractive errors (URE), and myopia constitutes a high proportion of them. URE should be screened and treated early to prevent long-term complications. The aim of this study was to determine the prevalence of myopia among all patients attending a pediatric outpatient clinic at Ohud Hospital in Medina, Saudi Arabia (KSA). Read More

View Article
November 2018

Impact of a digital health intervention on asthma resource utilization.

World Allergy Organ J 2018 3;11(1):28. Epub 2018 Dec 3.

Propeller Health, 47 Maiden Lane, San Francisco, CA 94108 USA.

Digital health interventions have been associated with reduced rescue inhaler use and improved controller medication adherence. This quality improvement project assessed the benefit of these interventions on asthma-related healthcare utilizations, including hospitalizations, emergency department (ED) utilization and outpatient visits. The intervention consisted of electronic medication monitors (EMMs) that tracked rescue and controller inhaler medication use, and a digital health platform that presented medication use information and asthma control status to patients and providers. Read More

View Article
December 2018

Mental capacity in Colombia: a comparison with the UK.

BJPsych Int 2018 Nov;15(4):85-88

Clinical Senior Lecturer in Mental Health, Ethics and Law, Wellcome Trust Senior Research Fellow, Institute of Psychiatry, Psychology and Neuroscience, King's College London.

Several international proclamations in the last decades have advocated for the dignity and autonomy of persons with mental disorders. Few discussions have been generated regarding the implication of this transition in low- and middle-income countries. The objective of this publication is to review how the concept of mental capacity has been defined in Colombian law. Read More

View Article
November 2018

57-Year-Old Man With Atypical Chest Pain.

Mayo Clin Proc 2018 Dec 24;93(12):1853-1857. Epub 2018 Oct 24.

Advisor to resident and Consultant in Cardiovascular Diseases, Mayo Clinic, Rochester, MN. Electronic address:

View Article
December 2018
1 Read

Aiding the diagnosis of dissociative identity disorder: pattern recognition study of brain biomarkers.

Br J Psychiatry 2018 Dec 7:1-9. Epub 2018 Dec 7.

Professor of Neuroimaging in Psychiatry,Department of Psychiatry,VU University Medical Center,The Netherlands.

Background: A diagnosis of dissociative identity disorder (DID) is controversial and prone to under- and misdiagnosis. From the moment of seeking treatment for symptoms to the time of an accurate diagnosis of DID individuals received an average of four prior other diagnoses and spent 7 years, with reports of up to 12 years, in mental health services.AimTo investigate whether data-driven pattern recognition methodologies applied to structural brain images can provide biomarkers to aid DID diagnosis. Read More

View Article
December 2018

Patient-Centered Medical Homes in Community Oncology Practices: Changes in Spending and Care Quality Associated With the COME HOME Experience.

J Oncol Pract 2018 Dec 5:JOP1800479. Epub 2018 Dec 5.

University of Kentucky College of Public Health, Lexington, KY; University of Tennessee Health Science Center, Memphis, TN; Mongan Institute, Massachusetts General Hospital, Boston, MA; Innovative Oncology Business Solutions; New Mexico Oncology Hematology Consultants, Albuquerque, NM; National Cancer Care Alliance, Dover, DE; and American Medical Association Board of Trustees, Chicago, IL.

Purpose:: We examined whether the Community Oncology Medical Home (COME HOME) program, a medical home program implemented in seven community oncology practices, was associated with changes in spending and care quality.

Patients And Methods:: We compared outcomes from elderly fee-for-service Medicare beneficiaries diagnosed between 2011 and 2015 with breast, lung, colorectal, thyroid, or pancreatic cancer, lymphoma, or melanoma and served by COME HOME practices before and after program implementation versus similar beneficiaries served by other geographically proximate oncologists. Difference-in-differences analysis compared changes in outcomes for COME HOME patients versus concurrent controls. Read More

View Article
December 2018

A systematic review and meta-analysis of the effects of antenatal anxiety on postpartum outcomes.

Arch Womens Ment Health 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry, Sunnybrook Health Sciences Centre and the University of Toronto, FG29 - 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.

To systematically review and meta-analyze research investigating the association between maternal anxiety during pregnancy and outcomes for mother and baby following the immediate delivery period. MEDLINE, Medline In-Process & Other Non-Indexed Citations, PsycINFO, Embase, CINAHL, and the Cochrane library were searched. English-language, prospective studies providing data on outcomes following delivery in women with and without antenatal anxiety (defined by clinical diagnosis or score on validated scale) were included. Read More

View Article
December 2018