52,121 results match your criteria Consultant For Pediatricians [Journal]


Feasibility Trial Evaluation of a Peer Volunteering Active Aging Intervention: ACE (Active, Connected, Engaged).

Gerontologist 2019 Feb 19. Epub 2019 Feb 19.

School of Policy Studies, University of Bristol, UK.

Background: ACE (Active, Connected, Engaged) is a theory-informed, pragmatic intervention using peer volunteering support to promote active ageing in socially disengaged, inactive older adults. This study aimed to establish ACE's feasibility and acceptability.

Methods: Fifty-four older adults were recruited as either peer volunteers (activators; n = 15) or participants (ACEs; n = 39). Read More

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http://dx.doi.org/10.1093/geront/gnz003DOI Listing
February 2019

Rural-urban disparities in missed opportunities for vaccination in sub-Saharan Africa: a multi-country decomposition analyses.

Hum Vaccin Immunother 2019 Feb 19. Epub 2019 Feb 19.

a Cochrane South Africa, South African Medical Research Council , Tygerberg , South Africa.

Background: In this study, we aimed to explore the rural-urban disparities in the magnitude and determinants of missed opportunities for vaccination (MOV) in sub-Saharan Africa.

Methods: This was a cross-sectional study using nationally representative household surveys conducted between 2007 and 2017 in 35 countries across sub-Saharan Africa. The risk difference in MOV between rural or urban dwellers were calculated. Read More

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http://dx.doi.org/10.1080/21645515.2019.1575163DOI Listing
February 2019

Non-Targeted Analysis of a Non-Aqueous Phase Liquid From A Chemical Manufacturing Site Using NMR Spectroscopy.

Environ Toxicol Chem 2019 Feb 19. Epub 2019 Feb 19.

School of Environmental Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

Non-aqueous phase liquids (NAPLs), composed primarily of organic solvents and other immiscible liquids, can be found in the subsurface at many industrial sites. The chemical composition of NAPL is often complex and, in many instances, difficult to fully characterize using conventional analytical techniques based on targeted compound analysis. Incomplete characterization of NAPL leaves gaps in the understanding of the chemical profile at an impacted site. Read More

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http://dx.doi.org/10.1002/etc.4394DOI Listing
February 2019

A comparative analysis of the pharmacovigilance systems of Brazil, Spain, the European Union and the United States based on the information provided by their regulatory agency websites.

Daru 2019 Feb 18. Epub 2019 Feb 18.

Pharmaceutical Care Research Group, Faculty of Pharmacy, University of Granada, 18071, Granada, Spain.

Background: Pharmacovigilance (PV) plays an essential role in monitoring and raising awareness of adverse drug reactions (ADRs). Increasingly, ADRs are reported and PV information and activities are circulated via the Internet. PV actions are carried out by the Regulatory Agencies (RAs) responsible for medicinal products in each country. Read More

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http://dx.doi.org/10.1007/s40199-019-00249-4DOI Listing
February 2019

Statistical fallacies & errors can also jeopardize life & health of many.

Authors:
Abhaya Indrayan

Indian J Med Res 2018 Dec;148(6):677-679

Biostatistics Consultant, Max Healthcare, Saket, New Delhi 110 017 & Former Professor, Department of Biostatistics & Medical Informatics, University College of Medical Sciences, Delhi 110 095, India.

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http://dx.doi.org/10.4103/ijmr.IJMR_853_18DOI Listing
December 2018

How should one tackle prediabetes in India?

Indian J Med Res 2018 Dec;148(6):675-676

Unit-1 Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, Vellore 632 004, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijmr.IJMR_1785_18DOI Listing
December 2018

Preservation vs. resection of the infrapatellar fat pad during total knee arthroplasty part 1: A survey of current practice in the UK.

Knee 2019 Feb 15. Epub 2019 Feb 15.

Leeds Institute of Rheumatic & Musculoskeletal Medicine, University of Leeds, United Kingdom.

Background: The management of the infrapatellar fat pad (IPFP) during total knee arthroplasty (TKA) is the subject of ongoing debate. In part 1 of this two-part series, we present an overview of current practice regarding the management of the IPFP in elective TKA among surgeons in the UK.

Methods: A web-based survey was offered to 269 delegates of the BASK 2017 annual conference. Read More

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http://dx.doi.org/10.1016/j.knee.2018.12.010DOI Listing
February 2019

A Primary Care Intervention to Prevent Repeat Pregnancy Among Teen Mothers.

Am J Prev Med 2019 Mar;56(3):404-410

Goldberg Center for Community Pediatrics, Children's National Health System, Washington, District of Columbia.

Introduction: The purpose of this study is to determine the effectiveness of a patient-centered medical home intervention for teen parent families in reducing rates of unintended repeat pregnancy in the first 2 years postpartum.

Methods: A prospective quasi-experimental evaluation was conducted with 98 African American, low-income, teen mother (aged <20 years) participants who received either the intervention or standard pediatric primary care. All participants completed structured interviews at baseline (child aged 2 months) and at follow-ups 12 and 24 months later. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.015DOI Listing

Referral patterns through the lens of health facility readiness to manage obstetric complications: national facility-based results from Ghana.

Reprod Health 2019 Feb 18;16(1):19. Epub 2019 Feb 18.

Maternal Child Health, MEASURE Evaluation/ Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Introduction: Countries with high maternal and newborn mortality can benefit from national facility level data that describe intra-facility emergency referral patterns for major obstetric complications. This paper assesses the relationship between referral and facilities' readiness to treat complications at each level of the health system in Ghana. We also investigate other facility characteristics associated with referral. Read More

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http://dx.doi.org/10.1186/s12978-019-0684-yDOI Listing
February 2019

Rivaroxaban for venous thromboembolism prevention after major orthopedic surgery: translating trial data into routine clinical practice.

Orthop Res Rev 2017 31;9:1-11. Epub 2017 Jan 31.

Department of Medicine, General Division, Hamilton Health Sciences, Hamilton, ON, Canada.

An established standard of care for the prevention of venous thromboembolism after major orthopedic surgery has been subcutaneous low-molecular-weight heparin. The non-vitamin K antagonist oral anticoagulant rivaroxaban has demonstrated superior efficacy and similar safety to all tested regimens of enoxaparin in large Phase III clinical studies of venous thromboembolism prevention after elective hip and knee arthroplasty. Despite regulatory approval of rivaroxaban for this indication, concerns remain among physicians regarding its optimal and effective use in routine clinical practice. Read More

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http://dx.doi.org/10.2147/ORR.S105227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209349PMC
January 2017

Variation in anti-microbial prescription and complications post emergency appendicectomy in Australia: do we follow recommended guidelines?

ANZ J Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Surgery, Gold Coast University Hospital, Gold Coast, Queensland, Australia.

Background: This study aims to establish compliance levels to prescription guidelines among Australian surgeons in the use of antibiotics in the surgical management of appendicitis. The secondary outcomes are predictors of post-operative infective complications; surgical site infection (SSI) and intra-abdominal abscess (IAA) at 30 days.

Methods: A multi-centre, prospective, observational study was conducted over a period of 2 months with a 30-day follow-up. Read More

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http://dx.doi.org/10.1111/ans.15099DOI Listing
February 2019

Parvovirus B19-Induced Severe Anemia in Heart Transplant Recipients: Case Report and Review of the Literature.

Clin Transplant 2019 Feb 18:e13498. Epub 2019 Feb 18.

Department of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.

We report a case of a 64-year-old woman who developed transfusion-dependent anemia after cardiac transplantation, the etiology of which was unknown after initial comprehensive evaluation. At the suggestion of the Transplant Infectious Diseases consultant, microbial agents with red blood cell tropism pertinent to this patient such as Parvovirus B 19 (B19V) were investigated. The B19V viral load by PCR in peripheral blood was >100,000,000 copies/ml and after treatment with intravenous immunoglobulin (IVIG), her anemia resolved. Read More

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http://dx.doi.org/10.1111/ctr.13498DOI Listing
February 2019

A Trans-Atlantic Perspective on Stagnation in Clinical Translation of Antimicrobial Strategies for the Control of Biomaterial-Implant-Associated Infection.

ACS Biomater Sci Eng 2019 Feb 2;5(2):402-406. Epub 2018 Dec 2.

Departments of Bioengineering, Pharmaceutics, and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, Utah 84112-5820, United States.

Current regulatory requirements impede clinical translation and market introduction of many new antimicrobial combination implants and devices, causing unnecessary patient suffering, doctor frustration, and costs to healthcare payers. Regulatory requirements of antimicrobial combination implants and devices should be thoroughly revisited and their approval allowed based on enrichment of benefit demonstrations from high-risk patient groups and populations or device components to facilitate their clinical translation. Biomaterial implant and devices equipped with antimicrobial strategies and approved based on enrichment claims should be mandatorily enrolled in global registry studies supervised by regulatory agencies for a minimum five-year period or until statistically validated evidence for noninferiority or superiority of claims is demonstrated. Read More

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http://dx.doi.org/10.1021/acsbiomaterials.8b01071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373985PMC
February 2019

Mechanical and Microstructural Properties of Native Pediatric Posterior Cruciate and Collateral Ligaments.

Orthop J Sports Med 2019 Feb 4;7(2):2325967118824400. Epub 2019 Feb 4.

Biedermann Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: Although anterior cruciate ligament (ACL) tears have received the most attention, the medial collateral ligament (MCL) is thought to be the most commonly injured knee ligament overall. The lateral collateral ligament (LCL) and posterior collateral ligament (PCL) are less frequently compromised but can be involved in severe multiligament injuries. The paucity of information on the native properties of these ligaments in the pediatric population hinders the overall optimization of treatment for these injuries. Read More

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http://dx.doi.org/10.1177/2325967118824400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362518PMC
February 2019

Should spirometer quality control be treated like other laboratory devices?

ERJ Open Res 2019 Feb 11;5(1). Epub 2019 Feb 11.

Division of Pulmonary, Critical Care, and Sleep Medicine, St Louis University, St Louis, MO, USA.

http://ow.ly/Pqdq30nwAmb. Read More

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http://dx.doi.org/10.1183/23120541.00249-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368997PMC
February 2019

Outcomes of Fusions From the Cervical Spine to the Pelvis.

Global Spine J 2019 Feb 10;9(1):6-13. Epub 2018 May 10.

University of California, San Francisco, CA, USA.

Study Design: Retrospective cohort study.

Objective: Determine the indications, complications, and clinical outcomes in patients requiring fusions from the cervical spine to the pelvis. Several investigators have examined fusions from the thoracic spine to the sacrum, but no similar study has been performed for cervical-to-pelvis fusions. Read More

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http://dx.doi.org/10.1177/2192568217705655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362548PMC
February 2019

Enduring Clinical Value of Copaxone® (Glatiramer Acetate) in Multiple Sclerosis after 20 Years of Use.

Authors:
Daniel R Wynn

Mult Scler Int 2019 15;2019:7151685. Epub 2019 Jan 15.

Director, Clinical Research; Consultants in Neurology, Multiple Sclerosis Center, Northbrook, IL, USA.

Multiple sclerosis (MS) is a chronic progressive neurodegenerative demyelinating disease affecting the central nervous system. Glatiramer acetate (GA; Copaxone®) was the first disease-modifying treatment (DMT) for MS successfully tested in humans (1977) and was approved by the US Food and Drug Administration in December 1996. Since then, there have been numerous developments in the MS field: advances in neuroimaging allowing more rapid and accurate diagnosis; the availability of a range of DMTs including immunosuppressant monoclonal antibodies and oral agents; a more holistic approach to treatment by multidisciplinary teams; and an improved awareness of the need to consider a patient's preferences and patient-reported outcomes such as quality of life. Read More

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http://dx.doi.org/10.1155/2019/7151685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350531PMC
January 2019

Path analyses of risk factors for linear growth faltering in four prospective cohorts of young children in Ghana, Malawi and Burkina Faso.

BMJ Glob Health 2019 13;4(1):e001155. Epub 2019 Jan 13.

Department of Nutrition, University of California Davis, Davis, California, USA.

Stunting prevalence is an indicator of a country's progress towards United Nations' Sustainable Development Goal 2, which is to end hunger and achieve improved nutrition. Accelerating progress towards reducing stunting requires a deeper understanding of the factors that contribute to linear growth faltering. We conducted path analyses of factors associated with 18-month length-for-age z-score (LAZ) in four prospective cohorts of children who participated in trials conducted as part of the International Lipid-Based Nutrient Supplements Project in Ghana (n=1039), Malawi (n=684 and 1504) and Burkina Faso (n=2619). Read More

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http://dx.doi.org/10.1136/bmjgh-2018-001155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350712PMC
January 2019

Parents and clinicians: partners in perinatal bereavement research -experiences from the International Stillbirth Alliance Conference 2017.

Res Involv Engagem 2019 1;5. Epub 2019 Feb 1.

1Pregnancy Loss Research Group, Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland.

In recent years, there has been a global call to reduce the numbers of preventable stillbirths and increase public awareness about the incidence and impact of pregnancy loss. The lived experiences of bereaved parents have much to contribute to developing the research agenda and clinical care in pregnancy loss. The multidisciplinary Pregnancy Loss Research Group (PLRG) based at the INFANT Centre at University College Cork and Cork University Maternity Hospital, has an established practice of active engagement and participation of patient members. Read More

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http://dx.doi.org/10.1186/s40900-018-0137-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357380PMC
February 2019

The short inventory of grazing (SIG): development and validation of a new brief measure of a common eating behaviour with a compulsive dimension.

J Eat Disord 2019 7;7. Epub 2019 Feb 7.

1School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, 2751 NSW Australia.

Background: Grazing, the repetitious and unplanned eating of small amounts of food with or without a sense of loss of control (LOC), is an eating pattern of recent interest which is highly prevalent in eating disorders and obesity. The current study aimed to (1) assess psychometric properties of a short inventory of grazing (SIG), consisting of a "grazing in general" item and a "compulsive/LOC grazing" item and (2) examine associations between compulsive and non-compulsive grazing and body mass index (BMI), eating disorder psychopathology, distress and health-related quality of life.

Methods: Participants recruited from a university and the community ( = 227; 75. Read More

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http://dx.doi.org/10.1186/s40337-019-0234-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366119PMC
February 2019

Idiopathic pulmonary fibrosis: prognostic impact of histologic honeycombing in transbronchial lung cryobiopsy.

Multidiscip Respir Med 2019 8;14. Epub 2019 Feb 8.

1Department of Thoracic Diseases, G.B. Morgagni - L. Pierantoni Hospital, Via C. Forlanini 34, 47121 Forlì, FC Italy.

Background: Prognostic evaluation in idiopathic pulmonary fibrosis (IPF) may be important as it can guide management decisions, but the potential role of honeycomb changes in providing information about outcome and survival of patients with IPF, particularly if diagnosed using cryobiopsy, has not been evaluated. Aim of this study was to determinate whether a relationship exists between honeycombing on cryobiopsy and clinical/radiological picture and outcome in patients with IPF and to assess whether the same pathologic criteria that have been used to define the UIP pattern (usual interstitial pneumonia) for surgical biopsy can also be applied to cryobiopsy.

Methods: Sixty-three subjects with a multidisciplinary diagnosis of IPF and a UIP pattern on cryobiopsy were evaluated. Read More

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http://dx.doi.org/10.1186/s40248-019-0170-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367843PMC
February 2019

Subclinical Atrial Fibrillation, Embolic Risk, and Anticoagulant Treatment.

Authors:
Leonida Gherasim

Maedica (Buchar) 2018 Dec;13(4):261-265

Honorary Member of the Romanian Academy Professor, "Carol Davila" University of Medicine and Pharmacy, Senior consultant, Emergency University Hospital, Bucharest, Romania.

Professor Leonida Gherasim, MD, PhD, is a member of the Romanian Academy. We invited him to write the editorial review for this issue. The subject - how to treat the silent atrial fibrillation (that fibrillation discovered only by devices) and take the decision to anti coagulate or not - is a very important clinical judgement. Read More

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http://dx.doi.org/10.26574/maedica.2018.13.4.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362888PMC
December 2018

Endoscopic Ultrasound-Guided Ablation of Pancreatic Cysts.

Authors:
William R Brugge

Gastroenterol Hepatol (N Y) 2018 Oct;14(10):602-604

Professor of Medicine Harvard Medical School Boston, Massachusetts Chief, Division of Gastroenterology Mount Auburn Hospital Cambridge, Massachusetts.

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October 2018

The use of patient-reported outcome research in modern ophthalmology: impact on clinical trials and routine clinical practice.

Patient Relat Outcome Meas 2019 24;10:9-24. Epub 2019 Jan 24.

Centre for Patient Reported Outcomes Research and NIHR Birmingham Biomedical Research Centre, University of Birmingham, Edgbaston, Birmingham, UK,

This review article considers the rising demand for patient-reported outcome measures (PROMs) in modern ophthalmic research and clinical practice. We review what PROMs are, how they are developed and chosen for use, and how their quality can be critically appraised. We outline the progress made to develop PROMs in each clinical subspecialty. Read More

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http://dx.doi.org/10.2147/PROM.S162802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352858PMC
January 2019

The impact of initial antibiotic treatment failure: real-world insights in patients with complicated, health care-associated intra-abdominal infection.

Infect Drug Resist 2019 31;12:329-343. Epub 2019 Jan 31.

Department of Medicine, Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena - Instituto de Biomedicina de Sevilla (IBiS), Universidad de Sevilla, Seville, Spain,

Purpose: The RECOMMEND study (NCT02364284; D4280R00005) assessed the clinical management patterns and treatment outcomes associated with initial antibiotic therapy (IAT; antibiotics administered ≤48 hours post-initiation of antibiotic therapy) for health care-associated infections across five countries.

Patients And Methods: Data were collected from a retrospective chart review of patients aged ≥18 years with health care-associated complicated intra-abdominal infection (cIAI). Potential risk factors for IAT failure were identified using logistic regression analyses. Read More

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http://dx.doi.org/10.2147/IDR.S184116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362915PMC
January 2019

Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation.

Neuropsychiatr Dis Treat 2019 23;15:311-321. Epub 2019 Jan 23.

CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada,

Background: Cigarette smoking is the leading preventable cause of death; however, quitting is difficult and early relapse is common. Dysphoric mood during early cigarette withdrawal is associated with relapse, and with the exception of bupropion and nortriptyline, few interventions have been developed to prevent this. During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood. Read More

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http://dx.doi.org/10.2147/NDT.S172334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352866PMC
January 2019

Dry eye disease ranking among common reasons for seeking eye care in a large US claims database.

Clin Ophthalmol 2019 1;13:225-232. Epub 2019 Feb 1.

Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

Objectives: Dry eye disease (DED) is a complex multifactorial condition of the ocular surface characterized by symptoms of ocular discomfort, irritation, and visual disturbance. Data previously reported from this study showed an increase in prevalence and incidence of DED with age and over time. The objective of this study was to compare the ranking of DED prevalence among other ocular conditions that led patients to seek eye care. Read More

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http://dx.doi.org/10.2147/OPTH.S188314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362914PMC
February 2019

Effect of systemic antihypertensives on change in intraocular pressure after initiating topical prostaglandins for primary open-angle glaucoma.

Clin Ophthalmol 2019 23;13:207-213. Epub 2019 Jan 23.

Medical Center Ophthalmology Associates, San Antonio, TX, USA,

Purpose: There is a limited understanding of factors that influence the efficacy of topical glaucoma medication. Our study is a long-term, case-control analysis of how systemic antihypertensive (anti-HTN) medications influence the change in IOP after initiating prostaglandin (PG) drop therapy.

Materials And Methods: A retrospective chart review of 3,781 patients was performed on patients with a diagnosis of glaucoma suspect that progressed to primary open-angle glaucoma (POAG) by ICD-9 codes over a 10-year period. Read More

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http://dx.doi.org/10.2147/OPTH.S192010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350645PMC
January 2019

Response to: "Tanezumab: Therapy targeting nerve growth factor in pain pathogenesis".

J Anaesthesiol Clin Pharmacol 2018 Oct-Dec;34(4):548

Formerly of Pfizer Global Research and Development (Rinat), Pfizer Inc., South San Francisco, California, USA.

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http://dx.doi.org/10.4103/joacp.JOACP_155_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360903PMC
February 2019

Using the Dietary Supplement Label Database to Identify Potentially Harmful Dietary Supplement Ingredients.

Nutr Today 2018 Sep-Oct;53(5):229-233

Professor at the Uniformed Services University and Director of the Consortium for Health and Military Performance (CHAMP).

Over half of young adults, athletes, and Military Service Members self-report using at least one dietary supplement (DS) 1 or more times per week. DS may be consumed to improve health, provide more energy, increase muscle strength, and/or enhance performance. The United States Food and Drug Administration (FDA) has raised concerns regarding adulteration, safety, and adverse events associated with DS marketed for brain health and bodybuilding. Read More

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http://dx.doi.org/10.1097/NT.0000000000000295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372126PMC
September 2019

Asperger's Children: The Origins of Autism in Nazi Vienna By Edith Sheffer. W.W. Norton and Company. 2018. 320 pp. £18.99 (hb). ISBN 9780393609646.

Br J Psychiatry 2019 Mar;214(3):176

Consultant in Old Age Psychiatry,Cambridgeshire and Peterborough NHS Foundation Trust,Elizabeth House,Fulbourn Hospital,Fulbourn,Cambridge CB21 5EF,UK;and Associate Lecturer,University of Cambridge,UK.

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http://dx.doi.org/10.1192/bjp.2019.15DOI Listing

An odd choice for an editorial!

Authors:
Andrew Firestone

Br J Psychiatry 2019 Mar;214(3):172

Consultant Psychiatrist,private practice,Australia.

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http://dx.doi.org/10.1192/bjp.2018.238DOI Listing

Capacity is only one aspect of decision-making at life's end.

Authors:
Eugene G Breen

Br J Psychiatry 2019 Mar;214(3):171-172

Consultant Psychiatrist,Associate Clinical Professor,Mater Hospital Dublin,University College Dublin,Ireland.

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http://dx.doi.org/10.1192/bjp.2018.237DOI Listing

Deep brain stimulation and revising the Mental Health Act: the case for intervention-specific safeguards.

Br J Psychiatry 2019 Mar;214(3):133-136

Uehiro Chair in Practical Ethics,Oxford Functional Neurosurgery,University of Oxford,UK.

Under the current Mental Health Act of England and Wales, it is lawful to perform deep brain stimulation in the absence of consent and independent approval. We argue against the Care Quality Commission's preferred strategy of addressing this problematic issue, and offer recommendations for deep brain stimulation-specific provisions in a revised Mental Health Act.Declaration of interestT. Read More

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http://dx.doi.org/10.1192/bjp.2018.200DOI Listing

The public health case for the four-day working week.

Authors:
John R Ashton

J R Soc Med 2019 Feb;112(2):81-82

Independent Public Health Consultant, Liverpool L25 5JF, UK.

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http://dx.doi.org/10.1177/0141076819826782DOI Listing
February 2019

Impact of transcranial magnetic stimulation on the symptom profile of major depressive episode.

Australas Psychiatry 2019 Feb 18:1039856219828134. Epub 2019 Feb 18.

Professor, School of Medicine, University of Tasmania, Hobart, TAS.

Objectives:: This study aimed to explore the effects of a four-week course of transcranial magnetic stimulation (TMS) on the following symptoms of major depressive episode (MDE): mood, work activities, health concerns, guilt, anxiety and retardation.

Method:: Patients underwent 20 daily sessions of 10 Hz TMS (two sets of 10 daily treatments separated by two days of rest). The six-item Hamilton Depression Rating Scale (HAMD-6) was administered before and after treatment. Read More

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http://journals.sagepub.com/doi/10.1177/1039856219828134
Publisher Site
http://dx.doi.org/10.1177/1039856219828134DOI Listing
February 2019
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U.K. hemophilia treaters' knowledge of risk assessment for prolonged bleeding associated with dental procedures.

Spec Care Dentist 2019 Feb 17. Epub 2019 Feb 17.

Professor and Consultant in Special Care Dentistry , Division of Public & Child Dental Health, Dublin Dental University Hospital, University of Dublin, Trinity College Dublin, Lincoln Place, Dublin 2.

Introduction: Optimal delivery of dental care for adults with congenital bleeding disorders (CBD) requires close collaboration between hemophilia treaters and dentists.

Aim: To explore U.K. Read More

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http://dx.doi.org/10.1111/scd.12359DOI Listing
February 2019

Birth choices for women in a 'Positive Birth after Caesarean' clinic: Randomised trial of alternative shared decision support strategies.

Aust N Z J Obstet Gynaecol 2019 Feb 18. Epub 2019 Feb 18.

School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Systematic approaches to information giving and decision support for women with previous caesarean sections are needed.

Aim: To evaluate decision support within a 'real-world' shared decision-making model.

Methods: A pragmatic comparative effectiveness randomised trial in the Positive Birth After Caesarean Clinic. Read More

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http://dx.doi.org/10.1111/ajo.12955DOI Listing
February 2019

Opportunities to bridge gaps between respiratory protection guidance and practice in US health care.

Infect Control Hosp Epidemiol 2019 Feb 18:1-6. Epub 2019 Feb 18.

National Personal Protective Technology Laboratory (NPPTL),National Institute for Occupational Safety Health (NIOSH),Pittsburgh,Pennsylvania.

Healthcare organizations are required to provide workers with respiratory protection (RP) to mitigate hazardous airborne inhalation exposures. This study sought to better identify gaps that exist between RP guidance and clinical practice to understand issues that would benefit from additional research or clarification. Read More

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http://dx.doi.org/10.1017/ice.2018.361DOI Listing
February 2019

Concept of disposable duodenoscope: at what cost?

Gut 2019 Feb 12. Epub 2019 Feb 12.

Center for Interventional Endoscopy, AdventHealth Orlando, Orlando, Florida, USA.

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http://dx.doi.org/10.1136/gutjnl-2019-318227DOI Listing
February 2019

Twelve-month analgesia and rescue, by cooled radiofrequency ablation treatment of osteoarthritic knee pain: results from a prospective, multicenter, randomized, cross-over trial.

Reg Anesth Pain Med 2019 Feb 16. Epub 2019 Feb 16.

Center for Clinical Research, Winston Salem, North Carolina, USA

Background And Objectives: As a follow-up to the 6-month report,12 this study investigated the analgesic effect of cooled radiofrequency ablation (CRFA) in patients with knee osteoarthritis (OA) 12 months postintervention and its ability to provide pain relief in patients who experienced unsatisfactory effects of intra-articular steroid injection (IAS).

Methods: Seventy-eight per cent (52/67) of patients originally treated with CRFA were evaluated at 12 months, while at 6 months post-IAS, 82% (58/71) of those patients crossed over to CRFA and assessed 6 months later.

Results: At 12 months, 65% of the original CRFA group had pain reduction ≥50%, and the mean overall drop was 4. Read More

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http://dx.doi.org/10.1136/rapm-2018-100051DOI Listing
February 2019

Continuing pharmacy education practices in geriatric care among pharmacists in the Upper Midwest.

J Am Pharm Assoc (2003) 2019 Feb 13. Epub 2019 Feb 13.

Objectives: To summarize select continuing pharmacy education (CPE) topics and hours related to geriatric care completed by community, hospital/clinic, and long-term care (LTC)/consultant pharmacists in the previous 12 months, whether pharmacy workplace influenced topic selection or completion, and to describe CPE sources used by community versus hospital/clinic pharmacists.

Design: Cross-sectional survey (2017).

Setting And Participants: Licensed pharmacists in North Dakota, South Dakota, Minnesota, Iowa, and Nebraska with primary practice settings in community pharmacies, hospitals, or clinics or those practicing as consultant pharmacists. Read More

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http://dx.doi.org/10.1016/j.japh.2018.12.020DOI Listing
February 2019
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Design errors in vital sign charts used in consultant-led maternity units in the United Kingdom.

Int J Obstet Anesth 2019 Jan 8. Epub 2019 Jan 8.

Centre for Midwifery, Maternal & Perinatal Health, Bournemouth University, Bournemouth, UK.

Background: Paper-based charts remain the principal means of documenting the vital signs of hospitalised pregnant and postnatal women. However, poor chart design may contribute to both incorrect charting of data and clinical responses. We decided to identify design faults that might have an adverse clinical impact. Read More

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http://dx.doi.org/10.1016/j.ijoa.2019.01.001DOI Listing
January 2019

Histopathologic differences in the endovenous laser ablation between jacketed and radial fibers, in an ex vivo dominant extrafascial tributary of the great saphenous vein in an in vitro model, using histology and immunohistochemistry.

J Vasc Surg Venous Lymphat Disord 2019 Mar;7(2):234-245

Research Department, The Whiteley Clinic, Guildford, Surrey, United Kingdom; Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom. Electronic address:

Objective: The study aimed to investigate the biologic effects of the 1470-nm endovenous laser (EVL), with a jacketed fiber and a radial fiber, during EVL ablation of an ex vivo dominant extrafascial tributary of the great saphenous vein in our in vitro model by histology and immunohistochemistry.

Methods: Ten segments of the dominant extrafascial tributary of the great saphenous vein were harvested by a consultant vascular surgeon from patients during routine varicose vein surgery. Six segments were treated using an ex vivo model of our design by a 1470-nm EVL with a jacketed fiber. Read More

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http://dx.doi.org/10.1016/j.jvsv.2018.09.017DOI Listing

Randomized Trial of Treat & Extend Ranibizumab With & Without Navigated Laser versus Monthly Dosing for DME: TREX-DME 2 Year Outcomes.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Retina Consultants of Houston, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX.

Purpose: To prospectively evaluate a treat & extend algorithm of ranibizumab with and without navigated laser to monthly dosing for center-involving diabetic macular edema.

Design: Multicenter, randomized, clinical trial METHODS: 150 eyes were randomized into three cohorts: Monthly (n=30), TReat and EXtend without laser photocoagulation (TREX; n=60), and treat and extend with angiography-GuIded LAser photocoagulation (GILA; n=60). Monthly cohort eyes received ranibizumab 0. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.005DOI Listing
February 2019

Parry-Romberg syndrome treatment with fat transfer and a new bleaching formula.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

ISAPS, Athens, Greece.

Parry-Romberg syndrome is a hemifacial atrophy which can be complicated by melasma. We present two cases of Parry-Romberg syndrome, treated by fat transfer and bleaching of the skin using a modified "Kligman's formula." The atrophy, as well as the skin dyschromia, improved, and the results were stable. Read More

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http://dx.doi.org/10.1111/jocd.12819DOI Listing
February 2019

OMERACT Filter 2.1: Elaboration of the Conceptual Framework for Outcome Measurement in Health Intervention Studies.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit; Department of Medical Humanities, VU University Medical Centre/EMGO+ institute, Amsterdam, the Netherlands; Institute for Work & Health and Institute for Health Policy Management and Evaluation, University of Toronto, Toronto; Centre for Practice-Changing Research, Ottawa Hospital Research Institute; Cardiovascular Research Methods Centre, University of Ottawa Heart Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario; McGill Centre for Outcomes Research and Evaluation, Montreal, Quebec, Canada; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland; Medicine Service, VA Medical Center; Department of Medicine, School of Medicine, University of Alabama; Division of Epidemiology, School of Public Health, University of Alabama, Birmingham, Alabama; SDG LLC, Cambridge, Massachusetts; Division of Immunology/Rheumatology, Stanford University School of Medicine, Palo Alto, California, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Hôpital Ambroise Paré, Rheumatology Department, Boulogne-Billancourt; INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint- Quentin University, Saint-Quentin en Yvelines; Sorbonne Université; Pitié Salpêtrière hospital, AP-HP, Rheumatology Department, Paris, France; Sydney Medical School, Institute of Bone and Joint Research; Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia. DEB, COB III, PGC, MAD, MPD, LG, LM, LS, JAS, VS, GAW, and PT are members of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies. PGC is funded in part by the NIHR Leeds Biomedical Research Centre. The views expressed in this article are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. JAS is supported by the resources and use of the facilities at the VA Medical Center at Birmingham, Alabama, USA. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government. LM is a principal investigator on the Australian Rheumatology Association Database, which has received armslength funding from Pfizer Australia, AbbVie Australia, Eli Lilly Australia, and Janssen Australia. M. Boers, MD, PhD, Professor of Clinical Epidemiology, Amsterdam UMC, Vrije Universiteit Amsterdam; D.E. Beaton, PhD, Senior Scientist, Institute for Work & Health, and Associate Professor, Institute Health Policy, Management and Evaluation, University of Toronto; B.J. Shea, PhD, Senior Scientist, Ottawa Hospital Research Institute, Clinical Epidemiology Program, and School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa; L.J. Maxwell, PhD, University of Ottawa and Centre for Practice-Changing Research, Ottawa Hospital Research Institute; S.J. Bartlett, PhD, Professor of Medicine, McGill University, Centre for Outcomes Research and Evaluation, and Division of Rheumatology, Department of Medicine, Johns Hopkins University; C.O. Bingham III, MD, Division of Rheumatology, Department of Medicine, Johns Hopkins University; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M.A. D'Agostino, MD, PhD, AP-HP, Professor of Rheumatology, Hôpital Ambroise Paré, Rheumatology Department, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University; M.P. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; L. Gossec, MD, PhD, Sorbonne Universités, UPMC Univ Paris 06, and AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology; L. March, MBBS, PhD, Liggins Professor of Rheumatology and Musculoskeletal Epidemiology, Sydney Medical School, Institute of Bone and Joint Research, and Department of Rheumatology, Royal North Shore Hospital; J.A. Singh, MBBS, MPH, Professor of Medicine and Epidemiology, Department of Medicine at the School of Medicine, University of Alabama at Birmingham; L.S. Simon, MD, Co-Managing Director of SDG LLC; V. Strand, MD, Biopharmaceutical Consultant, Portola Valley, California, USA; G.A. Wells, MSc, PhD, Director, Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, and Professor, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, MSc, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute. Address correspondence to Dr. M. Boers, Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands. Accepted for publication December 6, 2018.

Objective: The Outcome Measures in Rheumatology (OMERACT) Filter 2.0 framework was developed in 2014 to aid core outcome set development by describing the full universe of "measurable aspects of health conditions" from which core domains can be selected. This paper provides elaborations and updated concepts (OMERACT Filter 2. Read More

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http://dx.doi.org/10.3899/jrheum.181096DOI Listing
February 2019

OMERACT Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS) Assessment in Longitudinal Study.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Radiology and Diagnostic Imaging, University of Alberta; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; St. Vincent's Hospital, Melbourne, Australia. Supported by the Capital Health Chair in Diagnostic Imaging. Dr. Jaremko and Dr. Lambert are supported by Medical Imaging Consultants, Edmonton, Canada. J.L. Jaremko, MD, PhD, FRCPC, Department of Radiology and Diagnostic Imaging, University of Alberta; R.G. Lambert, MB, FRCPC, Department of Radiology and Diagnostic Imaging, University of Alberta; S.J. Pedersen, MD, Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases; U. Weber, MD, Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, and Hospital of Southern Jutland, University Hospital of the Region of Southern Denmark, and Department of Regional Health Research, University of Southern Denmark; D. Lindsay, MD, Department of Radiology and Diagnostic Imaging, University of Alberta; Z. Al-Ani, MD, Department of Radiology and Diagnostic Imaging, University of Alberta; K. Steer, BSc, Department of Radiology and Diagnostic Imaging, University of Alberta; M. Pianta, MD, St. Vincent's Hospital; S. Wichuk, BSc, Department of Medicine, University of Alberta; W.P. Maksymowych, MB ChB, FRCP(C), FACP, Department of Medicine, University of Alberta. Address correspondence to Dr. J.L. Jaremko, Radiologist and Associate Professor, Department of Radiology and Diagnostic Imaging, Faculty of Medicine, University of Alberta, 2A2.41 WMC, 8440-112 Street NW, Edmonton, Alberta T6G 2B7, Canada. E-mail: Accepted for publication December 5, 2018.

Objective: To assess reliability, feasibility, and responsiveness of Hip Inflammation Magnetic resonance imaging Scoring System (HIMRISS) for bone marrow lesions (BML) in hip osteoarthritis (OA).

Methods: HIMRISS was scored by 8 readers in 360 hips of 90 patients imaged pre/post-hip steroid injection. Pre-scoring, new readers trained online to achieve intraclass correlation coefficient (ICC) > 0. Read More

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http://dx.doi.org/10.3899/jrheum.181043DOI Listing
February 2019

Validity and Responsiveness of Combined Inflammation and Combined Joint Damage Scores Based on the OMERACT Rheumatoid Arthritis MRI Scoring System (RAMRIS).

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Rheumatology, Diakonhjemmet Hospital; Institute of Health and Society, University of Oslo, Oslo, Norway; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen; King Christian 10th Hospital for Rheumatic Diseases; University of Southern Denmark, Institute of Regional Health Research, Graasten; Institute of Clinical Medicine, Aarhus University Hospital, Århus; Odense University Hospital; Institute of Clinical Research, University of Southern Denmark, Odense; Zealand University Hospital, Køge, Denmark; University of New South Wales, Sydney, Australia; Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. U. Sundin, MD, Research Fellow, Department of Rheumatology, Diakonhjemmet Hospital, and Institute of Health and Society, University of Oslo; M. Østergaard, MD, PhD, DMSc, Professor, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet, and the Department of Clinical Medicine, University of Copenhagen; D. Glinatsi, MD, PhD, Postdoctoral Researcher, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; A.B. Aga, MD, PhD, Senior Consultant and Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital Oslo; K. Hørslev-Petersen, MD, DMSc, Professor, Senior Consultant, King Christian 10th Hospital for Rheumatic Diseases, and the Institute of Regional Health Research, University of Southern Denmark; M.L. Hetland, MD, PhD, DMSc, Professor, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet, and the Department of Clinical Medicine, University of Copenhagen; K. Stengaard-Pedersen, MD, DMSc, Professor Emeritus, Institute of Clinical Medicine, Aarhus University Hospital; P. Junker, MD, DMSc, Professor, Department of Rheumatology, Odense University Hospital and Institute of Clinical Research, University of Southern Denmark; B.J. Ejbjerg, MD, PhD, Chief Consultant, Zealand University Hospital; P. Bird, BMed (Hons), FRACP, PhD, Grad Dip MRI, Associate Professor, University of New South Wales; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S. Lillegraven, MD, MPH, PhD, Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital; E.A. Haavardsholm, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, and Institute of Health and Society, University of Oslo. Address correspondence to Dr. U. Sundin, Diakonhjemmet Sykehus, Diakonveien 12, 0370 Oslo, Norway. E-mail: Accepted for publication December 6, 2018.

Objective: The RAMRIS [Outcome Measures in Rheumatology rheumatoid arthritis (RA) magnetic resonance imaging (MRI) Scoring system] is used in clinical RA trials. We have investigated methods to combine the RAMRIS features into valid and responsive scores for inflammation and joint damage.

Methods: We used data from 3 large randomized early RA trials to assess 5 methods to develop a combined score for inflammation based on RAMRIS bone marrow edema, synovitis, and tenosynovitis scores, and a combined joint damage score based on erosions and joint space narrowing. Read More

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http://dx.doi.org/10.3899/jrheum.181064DOI Listing
February 2019