25,949 results match your criteria Constipation
J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.
CSIR-National Botanical Research Institute, Plant Transgenic Laboratory, P.O. Box 436, Rana Pratap Marg,Lucknow-226 001, U.P., India. Electronic address:
Ethnopharmacological Relevance: The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria bituminosa (Syn: P. bituminosa), P. Read More
PLoS One 2018 6;13(12):e0208571. Epub 2018 Dec 6.
Haaglanden Medical Center, The Hague, the Netherlands.
Aim: Increasing evidence exists with respect to the relation between stressful life events and functional constipation (FC). We aimed to investigate the prevalence of FC in Palestinian refugee preschool children and to determine if stress and trauma exposure are risk factors of FC in these children.
Methods: From November 2013 until May 2014, a cross-sectional survey was conducted in West Bank, Gaza and Jordan. Read More
Aging Clin Exp Res 2018 Dec 5. Epub 2018 Dec 5.
Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Purpose: Medication-related problems and declined functional capacity are closely associated factors among older people. The purpose of this study is to describe the procedure of interprofessional medication assessment in home care context and the baseline characteristics of the study population.
Methods: The FIMA study was a randomized, controlled intervention study comparing general practitioner-led interprofessional medication assessment and usual care. Read More
Dev Med Child Neurol 2018 Dec 3. Epub 2018 Dec 3.
Newcomen Developmental Service, Paediatric Neurosciences, Evelina London, Guy's and St Thomas' NHS Trust, King's Health Partners, London, UK.
Aim: We explored factors associated with pain and its severity in a population cohort of young people with bilateral cerebral palsy, comparing parent/carer and young people self-reports.
Method: Of 278 survivors (mean age 16y 8mo, SD 1y 4mo, range 13y 8mo-19y 3mo) from the South Thames in the Study of Hips and Physical Experience cohort of 338 young people with bilateral cerebral palsy, 212 parents/carers and 153 young people completed questionnaires on the presence, severity, timing, site, associated factors, impact, and treatment of pain.
Results: Seventy per cent of parents/carers reported pain within 3 months, 59% the previous week, and 50% the previous day with 56% reporting 'regularly experienced'. Read More
J Pediatr Rehabil Med 2018 Nov 19. Epub 2018 Nov 19.
Colorectal and Pelvic Malformations Center, Division of Gastroenterology, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Spina bifida is a birth defect that commonly causes bowel and bladder dysfunction in children with a significant negative impact on quality of life and emotional wellbeing. Fecal continence improves satisfaction and the quality of life of both children and their caretakers. Bowel management in children with spina bifida is hampered by limited controlled studies and variable practice within different institutions and subspecialists. Read More
World J Nucl Med 2018 Oct-Dec;17(4):249-252
Hospital de Base do Distrito Federal - Nuclear Medicine Service, Brasília, Brasil.
The aim of this study was to assess the colonic transit in children and teenagers with chronic constipation. Twenty patients from 1.5 to 16 years old were included (mean age = 6. Read More
J Cyst Fibros 2018 Nov 28. Epub 2018 Nov 28.
Gregory Fleming James Cystic Fibrosis Research Center Birmingham, AL, USA; The Department of Medicine, University of Alabama at Birmingham Birmingham, AL, USA. Electronic address:
Purpose: To raise awareness of colocolonic intussusception as a gastrointestinal complication of CF mimicking distal intestinal obstruction syndrome (DIOS) and discuss risk of recurrence.
Case Summary: A 33-year-old Caucasian male with cystic fibrosis presented with an acute abdomen diagnosed via imaging as colocolonic intussusception. He was managed with fluid replacement therapy and polyethylene glycol. Read More
J Surg Res 2019 Jan 29;233:173-182. Epub 2018 Aug 29.
Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address:
Background: Postoperative incontinence and constipation still remain the major complications of anorectal malformations (ARMs), despite improvements in their treatment. One of the most important factors that affect postoperative anorectal function is malformations in the lumbosacral spinal cord. However, far too little attention has been paid to the underlying mechanism that produces these malformations. Read More
Nutrients 2018 Nov 29;10(12). Epub 2018 Nov 29.
Department of Pediatrics, University of Turku, 20521 Turku, Finland.
The potential association between gut microbiota perturbations and childhood functional gastrointestinal disturbances opens interesting therapeutic and preventive possibilities with probiotics. The aim of this review was to evaluate current evidence on the efficacy of probiotics for the management of pediatric functional abdominal pain disorders, functional constipation and infantile colic. Thus far, no single strain, combination of strains or synbiotics can be recommended for the management of irritable bowel syndrome, functional abdominal pain or functional constipation in children. Read More
Australas J Dermatol 2018 Dec 4. Epub 2018 Dec 4.
Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China.
Recently, several studies have reported their experience in using oral atenolol in patients with infantile haemangioma (IH), especially as an alternative to propranolol, but the efficacy and safety of oral atenolol has not been evaluated. We searched PubMed (Medline), Central, Embase, Web of Science and EBSCOhost (until May 2018) for the eligible studies reporting more than 10 IH patients who were treated with oral atenolol with detailed original data, including outcomes, regimens and adverse events (AEs). The data was standardised and analysed by using R software with meta-package. Read More
J Clin Med 2018 Dec 1;7(12). Epub 2018 Dec 1.
Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Korea.
There is no treatment of choice for irritable bowel syndrome, which affects up to 20% of school-aged children. This cross-sectional study evaluated the difference in the average vitamin D level between subtypes of irritable bowel syndrome, and the relationship between the vitamin D level as well as the severity of irritable bowel syndrome symptoms. We included 124 adolescents aged 10⁻17 years (68 boys, 56 girls; mean age 12. Read More
South Med J 2018 Dec;111(12):716-720
From the Division of Emergency Medicine, Washington University School of Medicine, St Louis, Missouri, the Division of Emergency Medicine, Duke University, Durham, North Carolina, the Department of Emergency Medicine, East Carolina University Brody School of Medicine, Greenville, North Carolina, the Department of Emergency Medicine, Virginia Commonwealth University, Richmond, the Department of Emergency Medicine, Baylor College of Medicine, Houston, Texas, the Department of Emergency Medicine, University of North Carolina, Chapel Hill, North Carolina, Texas A&M Health Sciences Center, Bryan, Rocky Mountain Poison & Drug Center, Denver, Colorado, the Department of Emergency Medicine, UT Southwestern Medical Center, Dallas, Texas, the Department of Emergency Medicine, Augusta University, Augusta, Georgia, the Department of Emergency Medicine, University of Virginia, Charlottesville, the Department of Surgery, East Carolina University Brody School of Medicine, Greenville, North Carolina, and the Department of Surgery, Marshall University, Huntington, West Virginia.
Objective: To compare the incidence of hypersensitivity reactions following copperhead envenomation treated with Fab antivenom (FabAV) or placebo.
Methods: Patients with copperhead snakebites received treatment and follow-up in a prospective, randomized, double-blind, placebo-controlled trial of FabAV or placebo. The treatment allocation ratio was 2:1 (FabAV:placebo). Read More
Laeknabladid 2018 Dec;104(12):543-548
Department of Psychiatry, National University Hospital of Iceland.
Loperamide is a μ-opioid receptor agonist with antidiarrhoeal effects. It is considered to have a low abuse potential because of substantial first-pass metabolism and P-glycoprotein-mediated efflux at the level of the blood-brain barrier. Previous case reports have described that high dosage of loperamide can induce an opioid-like effect on the central nervous system. Read More
World J Urol 2018 Dec 3. Epub 2018 Dec 3.
Department of Urology and Urological Science Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Purpose: Antimuscarinics are the first pharmacological treatment option for neurogenic bladder in children with spina bifida but side effects limit their use. Mirabegron, a new β-3 adrenoceptor agonist with a distinct mechanism of action, is a potential agent for the treatment of neurogenic bladder; however, it has yet to be studied in the pediatric population. This study evaluated the efficacy and safety of mirabegron for treating neurogenic bladder in children with spina bifida. Read More
World J Clin Cases 2018 Nov;6(14):820-824
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Solitary rectal ulcer syndrome (SRUS) is a rare benign condition, which can mimic many other diseases because of their similarities in clinical, endoscopic and histological features. Sessile serrated adenoma/polyp (SSA/p) is a premalignant lesion in the colon and rectum. The misdiagnosis of SSA/p in SRUS patients has been noted, but the case of SRUS arising secondarily to SSA/p has been rarely reported. Read More
Lancet Infect Dis 2018 Dec 25;18(12):1319-1328. Epub 2018 Oct 25.
Shionogi & Co Ltd, Osaka, Japan.
Background: Carbapenem-resistant Gram-negative bacteria represent the highest priority for addressing global antibiotic resistance. Cefiderocol (S-649266), a new siderophore cephalosporin, has broad activity against Enterobacteriaceae and non-fermenting bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, including carbapenem-resistant strains. We assessed the efficacy and safety of cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infection in patients at risk of multidrug-resistant Gram-negative infections. Read More
J Pediatr Gastroenterol Nutr 2018 Nov 27. Epub 2018 Nov 27.
Division of Gastroenterology, Hepatology, and Nutrition, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Our objective is to compare coping methods, stress responses, and resilience in children with and without functional gastrointestinal disorders (FGIDs) in response to common sources of stress. We performed a case-control study. Children meeting criteria for FGIDs and matched controls completed measures of response to stress (Peer Stress, Family Stress, Academic Problems, and Recurrent Abdominal Pain versions of the Response to Stress Questionnaire) and resilience (Connor-Davidson Resilience Scale 10). Read More
BMJ Paediatr Open 2018 9;2(1):e000341. Epub 2018 Nov 9.
Division of Pediatric Surgery, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Introduction: Many children with acute abdominal pain and suspicion of appendicitis are diagnosed with constipation. Nevertheless, it can be difficult to differentiate between acute constipation and acute appendicitis because of similar symptoms and lack of diagnostic criteria. Consequently, constipation is often missed despite repeated consultations at the emergency department. Read More
Eur J Paediatr Neurol 2018 Nov 20. Epub 2018 Nov 20.
Dokuz Eylul University, Division of Pediatric Metabolism and Nutrition, Izmir, Turkey. Electronic address:
Purpose: Ketogenic diet (KD) is an effective non-pharmacological treatment for drug-resistant epilepsy. The aim of this study was to investigate the efficacy, tolerability and complications of olive oil-based KD in epileptic children.
Method: In this single-center, prospective study, patients were followed up at 1, 3, 6 and 12 months after KD initiation. Read More
Nutrition 2018 Aug 23;59:158-169. Epub 2018 Aug 23.
GSK Italy, Origgio, Varese, Italy.
Digestive health plays key role in our active daily life; but maintaining proper bowel movements, i.e., being free from constipation, diarrhea, irritable bowel syndrome, inflammatory bowel disease, flatulence, bloating, and abdominal pain, is complex. Read More
J R Coll Physicians Edinb 2018 Dec;48(4):378-382
112 Polwarth Terrace, Merchiston, Edinburgh EH11 1NN, UK.
Liquorice is a very ancient plant widely used in the East for millennia. It has often been employed in sweets and confectionery and also for minor ailments including cough, constipation and dyspepsia. It was probably carried to Europe by the Cluniac order of monks. Read More
J Sci Food Agric 2018 Nov 28. Epub 2018 Nov 28.
College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea.
Background: This study investigated the in vivo prophylactic effect of probiotic chocolate on constipation. Rats were administered with chocolate containing 2.5 × 10 CFU g of probiotics daily for four weeks and treated with loperamide (5 mg kg ) daily at the fourth week of treatment. Read More
Front Pharmacol 2018 14;9:1296. Epub 2018 Nov 14.
School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Monitoring of immunosuppressive drugs, such as calcineurin and mTOR inhibitors, is essential to avoid undesirable kidney transplant outcomes. Polymorphisms in pharmacokinetics-related genes have been associated with variability in blood levels of immunosuppressive drugs and adverse effects, but influence of pharmacodynamics-related genes remains to be elucidated. The influence of polymorphisms in genes of the mTOR and calcineurin signaling pathways on long-term clinical outcomes was investigated in Brazilian kidney transplant recipients within the 1-year post-transplant. Read More
Nutrients 2018 Nov 28;10(12). Epub 2018 Nov 28.
Nutrition Science Solutions, LLC, Wimberley, 78676 TX, USA.
Less than 10% of most Western populations consume adequate levels of whole fruits and dietary fiber with typical intake being about half of the recommended levels. Evidence of the beneficial health effects of consuming adequate levels of whole fruits has been steadily growing, especially regarding their bioactive fiber prebiotic effects and role in improved weight control, wellness and healthy aging. The primary aim of this narrative review article is to examine the increasing number of health benefits which are associated with the adequate intake of whole fruits, especially fruit fiber, throughout the human lifecycle. Read More
Food Funct 2018 Nov 28. Epub 2018 Nov 28.
College of Food and Bioengineering, South China University of Technology, Guangzhou, 510640, China.
Anthraquinone compounds with the anthraquinone ring structure are widely found in traditional Chinese medicines and they are attracting a lot of attention due to their good pharmacological activity. Diversities of anthraquinones depend on their chemical structures, such as the number of anthraquinone rings and the substituents; what's more, the difference in chemical structure determines the difference in physiological activity. Based on results of previous studies, this review summarizes several natural anthraquinones identified from Chinese herbal medicines and their physiological activities including anti-cancer, anti-pathogenic microorganisms, anti-inflammatory, anti-oxidation, anti-osteoporosis, anti-depression, and anti-constipation. Read More
Adv Ther 2018 Nov 27. Epub 2018 Nov 27.
University of Nevada at Reno, Reno, NV, USA.
Introduction: The objective of the study was to investigate the efficacy and safety of repeated incobotulinumtoxinA injections for the treatment of upper-limb post-stroke spasticity in adults.
Methods: Adults 18-80 years of age with post-stroke upper-limb spasticity who completed the 12-week randomized, double-blind, placebo-controlled main period (MP) of a phase 3 trial (NCT01392300) were eligible to enrol in the 36-week open-label extension period (OLEX). The OLEX included three treatment cycles at fixed 12-week injection intervals; subjects were injected with 400 U incobotulinumtoxinA into the affected upper limb. Read More
JGH Open 2018 Oct 5;2(5):217-222. Epub 2018 Aug 5.
Department of Gastroenterology Alfred Hospital and Monash University Melbourne Victoria Australia.
Background: The syndrome of constipation with other abdominal symptoms ("proximal constipation") in ulcerative colitis (UC) is commonly recognized by practitioners but is poorly described, with no recognized definition and little understanding with regard to prevalence and effect of therapies on disease outcomes. This study aimed to address these issues in a cross-sectional, consecutive series of patients with UC.
Methods: A working definition of proximal constipation was established. Read More
JGH Open 2018 Aug 27;2(4):144-151. Epub 2018 Jun 27.
Surgical Research Group Murdoch Children's Research Institute Melbourne Victoria Australia.
Background And Aim: Polyethylene glycol (PEG) is the gold standard for fecal disimpaction in constipation. A regimen of PEG combined with the stimulant laxative sodium picosulphate (SPS) produced fecal disimpaction in chronically constipated children in the community, but it is unknown if it is effective for more severe constipation. To determine the stool output and effect of a combined PEG and SPS regimen on fecaloma in children with severe constipation and impaction. Read More
Endocrinol Diabetes Metab Case Rep 2018 Nov 22;2018. Epub 2018 Nov 22.
Division of Pediatric Endocrinology, Children's Hospital of Orange County, Orange, California, USA.
In this case report, we present a novel mutation in Lim-homeodomain (LIM-HD) transcription factor, LHX3, manifesting as combined pituitary hormone deficiency (CPHD). This female patient was originally diagnosed in Egypt during infancy with Diamond Blackfan Anemia (DBA) requiring several blood transfusions. Around 10 months of age, she was diagnosed and treated for central hypothyroidism. Read More
Biomedicine (Taipei) 2018 Dec 26;8(4):21. Epub 2018 Nov 26.
Department of Neurosurgery, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Generally regarding as a safe treatment for Parkinson's disease (PD) for the past 20 years, deep brain stimulation (DBS) is also an example of precision medicine where surgeons need to titrate individual patient's stimulating electrodes one by one down to the scale of micrometer for the maximum therapeutic effect. In order to prevent operation induced psychiatric complications and minimize any other potential side effects, we have followed 103 patients received this treatment provided by a single surgeon in the same medical institution from 2004 to 2017. We identified each patient complaint from nursing care records and complication data from medical charts during the perioperative hospitalization period to see if any of them correlate statistical significantly with the DBS lead placement procedure. Read More
Surg Innov 2018 Nov 25:1553350618814090. Epub 2018 Nov 25.
1 Beijing Chao-Yang Hospital, Beijing, China.
Purpose: Animal models play an important role in abdominal wall hernia research. However, there is still no standard animal models for abdominal wall hernia. This study aimed to introduce a novel rabbit model of giant abdominal wall hernia. Read More
Acta Paediatr 2018 Nov 25. Epub 2018 Nov 25.
Department of Paediatrics and Nephrology, Children's Clinical Hospital of the Medical University of Bialystok, Bialystok, Poland.
Aim: The etiology of micturition disorders in children is multifactorial and still unclear. The perinatal factors may play a role in the development of children's urinary incontinence. We compared each type of micturition disorders in terms of length of gestation, birthweight, family history of bed-wetting and delivery type. Read More
Clin Transl Oncol 2018 Nov 23. Epub 2018 Nov 23.
The First Hospital of Jilin University, Jilin City, China.
Morphine is a classic opioid drug used for reducing pain and is commonly prescribed as an effective drug to control cancer pain. Morphine has a direct role in the central nervous system to relieve pain, but because of its peripheral functions, morphine also has some side effects, such as nausea, constipation, and addiction (Gupta et al. in Sci World J 2015:10, 2015). Read More
Aliment Pharmacol Ther 2018 Nov 22. Epub 2018 Nov 22.
Division of Gastroenterology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.
Background: Colon ischaemia is the most common ischaemic disorder of the gastrointestinal system, can affect any segment of the colon, and may present with a range of symptoms. Diagnosis can be challenging due to symptom overlap with other conditions, varied aetiology, and often rapid and self-resolving course.
Aim: To review comprehensively the literature regarding the pharmacological aetiologies of colonic ischaemia to enhance the understanding of the various mechanisms of disease, presentations, distribution, and outcomes. Read More
Int Urogynecol J 2018 Nov 22. Epub 2018 Nov 22.
Sector of Urogynecology, Department of Gynecology, Federal University of São Paulo, UNIFESP, Rua Barão do Triunfo, 427/1206, São Paulo, SP, CEP: 04602-001, Brazil.
Introduction And Hypothesis: We aim to compare total versus subtotal abdominal hysterectomy regarding urinary and bowel symptoms and pelvic organ prolapse at long-term follow-up.
Methods: A systematic literature search was performed on the MEDLINE, LILACS, Cochrane CENTRAL and SCOPUS databases and conference abstracts (AAGL, AUGS, ICS) from inception up to November 2017. We included randomized trials comparing total versus subtotal hysterectomy for benign conditions that evaluated pelvic floor symptoms over 5 years of follow-up. Read More
Phytomedicine 2018 Nov 31;50:300-308. Epub 2018 Jan 31.
Zoology Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt.
Background: Due to renowned medicinal properties, Ginger rhizomes (Zingiber officinale Roscoe) used traditionally in the treatment of arthritis, rheumatism, muscular aches, constipation, indigestion, hypertension, dementia, fever, and infectious diseases. As an antiemetic, Ginger is consumed by approximately 80% of pregnant women to treat nausea and vomiting of early pregnancy.
Purpose: The aim of this study is to evaluate the impact of ginger extract on the oestrous cycle and implantation in female mice. Read More
Urol Clin North Am 2019 Feb;46(1):79-85
Glickman Urological and Kidney Institute, Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Pelvic organ prolapse is common in parous women, although few report symptoms. The incidence of posterior compartment prolapse, or rectocele, is less well-reported. Posterior vaginal wall prolapse is associated with pain, constipation, and splinting. Read More
Med Clin North Am 2019 Jan;103(1):137-152
Department of Medicine, Division of Gastroenterology, Johns Hopkins University, 4940 Eastern Avenue, 3rd Floor, Baltimore, MD 21224, USA. Electronic address:
Irritable bowel syndrome (IBS) is present in patients with symptoms of chronic abdominal pain and altered bowel habits but no identifiable organic etiology. Rome IV classification groups patients based on predominant stool pattern. Low-FODMAP diets have been helpful in providing symptom relief, as have cognitive behavioral and mind-body techniques that help patients manage symptoms. Read More
J Pain Res 2018 26;11:2603-2616. Epub 2018 Oct 26.
Department of Orthopaedic Surgery, Shimane University School of Medicine, Shimane, Japan.
Purpose: To assess whether patients with knee osteoarthritis pain who have early pain reduction or treatment-related adverse events of special interest (TR-AESIs; constipation, decreased appetite, malaise, nausea, somnolence, thirst) with duloxetine treatment are more likely to have later improvements in pain and quality of life (QOL) relative to placebo than patients without these early indicators.
Patients And Methods: This was a post hoc analysis of 14-week randomized trial of Japanese patients with knee osteoarthritis pain (Brief Pain Inventory [BPI]-Severity average pain score ≥4) receiving duloxetine 60 mg/day (n=177 analyzed) or placebo (n=176). Primary trial outcome was change from baseline in BPI-Severity average pain at Week 14. Read More
Drug Discov Ther 2018 ;12(5):304-308
Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo.
We described fecal retention during the defecation cycles of adults with functional constipation via ultrasonography (US) of the large intestine. US was performed continuously after the last defecation until the next defecation. We defined the fecal finding level on US as follows: weak fecal retention, a marginally high echo in the colonic lumen; or strong fecal retention, a strongly echoic colon lumen with showing a crescent-shaped acoustic shadow on transverse images and haustrations on longitudinal images. Read More
Medicina (Kaunas) 2018 Nov 19;54(5). Epub 2018 Nov 19.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University (BTBU), Beijing 102488, China.
Paocai (pickled cabbage), which is fermented by lactic acid bacteria, is a traditional Chinese food. The microorganisms of Paocai were isolated and identified, and the constipation inhibition effect of one of the isolated was investigated. The 16S rDNA technology was used for microbial identification. Read More
J Laparoendosc Adv Surg Tech A 2018 Nov 21. Epub 2018 Nov 21.
1 Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China .
Background: Reoperations in Hirschsprung disease (HD) may be required due to pathological problems. We conducted this retrospective study to determine the incidence and outcomes of innervation disorders among HD patients following pull-through operation.
Materials And Methods: We retrospectively reviewed the data of patients who underwent pull-through procedure from 2005 to 2017. Read More
Invest New Drugs 2018 Nov 21. Epub 2018 Nov 21.
Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.
Introduction VLX600 is a novel iron chelator designed to interfere with intracellular iron metabolism, leading to inhibition of mitochondrial respiration and bioenergetic catastrophe and resultant tumor cell death. Methods We conducted a multicenter, phase 1, dose escalation study to determine the safety and adverse event profile and the maximum tolerated dose and recommended phase 2 dose of VLX600. Other endpoints included pharmacokinetics, and preliminary evidence of anti-cancer efficacy as assessed according to RECIST 1. Read More
Colorectal Dis 2018 Nov 20. Epub 2018 Nov 20.
Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida, USA.
Aim: Three-dimensional (3D) printing has been recognized as a revolutionary technological innovation that has benefitted numerous disciplines, including medicine. The present systematic review aimed to demonstrate the current applications of 3D printing in colorectal surgery along with the limitations and potential future applications of this innovation.
Method: A PRISMA-compliant systematic literature search of studies that applied 3D printing in colorectal surgery in the period from January 1990 to July 2018 was conducted. Read More
CNS Drugs 2018 Nov 19. Epub 2018 Nov 19.
Department of Psychological Medicine, University of Otago, PO Box 7343, Wellington, 6242, New Zealand.
Background: Gastrointestinal hypomotility in people taking clozapine is common, poorly understood and potentially dangerous. It causes distress and sometimes sudden death, with greater associated morbidity than the better known adverse effect of clozapine, agranulocytosis. Neither the mechanism nor prevalence of clozapine-induced gastrointestinal hypomotility is well understood. Read More
Pediatr Surg Int 2018 Nov 19. Epub 2018 Nov 19.
Japanese Study Group for Allied Disorders of Hirschsprung's Disease, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Purpose: Acquired isolated hypoganglionosis (A-IH) is a late-onset intestinal pseudo-obstruction disorder and shows different pathophysiological findings from congenital isolated hypoganglionosis (C-IH). In this study, we retrospectively examined five cases of A-IH and investigated the features of A-IH.
Methods: Five cases of A-IH were extracted from a nationwide retrospective cohort study in 10 years, from which totally 355 cases of Allied Disorders of Hirschsprung's Disease (ADHD) were collected. Read More
Clin Case Rep 2018 Nov 9;6(11):2029-2032. Epub 2018 Sep 9.
Department of Intestinal Bioscience and Medicine School of Medicine Fukushima Medical University Fukushima City Japan.
We have presented the first case report of FMT therapy for a patient with chronic intractable constipation. This therapy resulted in good, medium-term outcomes. Follow-up analysis of the intestinal flora suggested that transplanted microbes from the donor, particularly and cluster IX, may have been incorporated into the recipient. Read More
Int J Mol Sci 2018 Nov 16;19(11). Epub 2018 Nov 16.
Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Wien, Austria.
Irritable bowel syndrome (IBS) is a disorder with brain-gut-microbiome alterations. Gut-directed hypnotherapy (GHT) has been shown to improve quality of life and symptoms in IBS. This therapy targets psychological coping, central nervous processing and brain-gut interaction. Read More
Inflamm Bowel Dis 2018 Nov 19. Epub 2018 Nov 19.
Department of Gastroenterology, St Vincent's Hospital, Melbourne and University of Melbourne, Melbourne, Australia.
Background: Patients with inflammatory bowel disease (IBD) often experience functional bowel symptoms despite achieving disease remission. Although behavioral treatment (bowel and pelvic floor muscle retraining) is effective for managing constipation or fecal incontinence in non-IBD patients, there is limited evidence for its efficacy in patients with quiescent inflammatory bowel disease. The aim of this study was to evaluate the outcome of gut-directed behavioral treatment, including pelvic floor muscle training, for symptoms of constipation or fecal incontinence in patients with IBD in disease remission. Read More