28,398 results match your criteria Constipation


Understanding negative predictive values: Clozapine-treated people who do not complain of constipation probably still have slow gut.

Schizophr Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Psychological Medicine, University of Otago, Wellington, New Zealand; Capital and Coast District Health Board, Wellington, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2020.06.031DOI Listing

Quality of life of patients with metastatic pancreatic adenocarcinoma initiating first-line chemotherapy in routine practice.

BMC Palliat Care 2020 Jul 10;19(1):103. Epub 2020 Jul 10.

Institut Català d'Oncologia (ICO), Girona, Spain.

Background: Despite advances in surgery, radiotherapy, and chemotherapy, pancreatic adenocarcinoma often progresses rapidly and causes death. The physical decline of these patients is expected to impact their quality of life (QoL). Therefore, in addition to objective measures of effectiveness, the evaluation of health-related QoL should be considered a matter of major concern when assessing therapy outcomes. Read More

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http://dx.doi.org/10.1186/s12904-020-00610-4DOI Listing

Naldemedine: Peripherally-acting Opioid Receptor Antagonist for Treating Opioid-induced Adverse Effects.

Curr Top Med Chem 2020 Jul 9. Epub 2020 Jul 9.

Project Management Department, Global Development Division, Osaka. Japan.

Opioids are widely used for pain management in moderate-to-severe pain. However, opioids are associated with adverse events, such as constipation and emesis/vomiting. To reduce these undesired effects, a structure-activity relationship study of morphinan derivatives was conducted, and a promising lead compound with inhibitory effects on opioid receptors was obtained. Read More

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http://dx.doi.org/10.2174/1568026620666200710105953DOI Listing

Seven-Year Case-Control Study in California of Risk Factors for Infant Botulism.

J Pediatr 2020 Jul 6. Epub 2020 Jul 6.

Infant Botulism Treatment and Prevention Program, California Department of Public Health, 850 Marina Bay Parkway Richmond, CA 94804. Electronic address:

Objective: To ascertain possible risk factors for infant botulism, the intestinal infectious form of human botulism, in the years immediately following its initial recognition in California in 1976..

Study Design: Parents of 159 California laboratory-confirmed cases of infant botulism from 1976-1983 and 318 healthy controls were interviewed using a comprehensive (>300 factors) questionnaire. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.07.014DOI Listing

Search query interest for gastrointestinal symptoms associated with COVID-19 diagnosis: an infodemiology study.

JMIR Public Health Surveill 2020 Jul 8. Epub 2020 Jul 8.

Department of Gastroenterology and Hepatology, Weill Cornell Medicine New York NY, 1305 York Ave4th floor, New York, US.

Background: The coronavirus disease 2019 (COVID-19) is a novel viral illness that has rapidly spread worldwide. While the disease primarily presents as a respiratory illness, gastrointestinal symptoms such as diarrhea have been reported in up to a third of confirmed cases, and patients may have mild symptoms that do not prompt medical attention. Internet-based infodemiology approaches offer an approach to studying symptoms at a population level, even in patients who do not seek medical care. Read More

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http://dx.doi.org/10.2196/19354DOI Listing

Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of non-evoked ongoing pain.

Pain 2020 Jun 24. Epub 2020 Jun 24.

Department of Anesthesiology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.

Currently, opioids targeting mu-opioid receptors (MOR) are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a compound that does not evoke central or intestinal side effects due to its selective activation of MOR at low pH in peripheral injured tissues. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001968DOI Listing

Bimodal Release Ondansetron Improves Stool Consistency and Symptomatology in Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized, Double-Blind, Trial.

Am J Gastroenterol 2020 Jun 24. Epub 2020 Jun 24.

Middleburg Consultants, Takoma Park, Maryland, USA.

Introduction: Previous, small studies have suggested that ondansetron has beneficial effects in diarrhea-predominant irritable bowel syndrome (IBS-D). This randomized, double-blind study evaluated the efficacy and safety of daily 12 mg RHB-102, an investigational bimodal release ondansetron tablet, in IBS-D.

Methods: Men and women with IBS-D by the Rome III criteria, Bristol Stool Scale ≥6 on 2 or more days weekly, and average daily worst pain intensity ≥3/10 were randomized 60:40 to RHB-102 or placebo once daily for 8 weeks. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000727DOI Listing

Health benefits of xylitol.

Appl Microbiol Biotechnol 2020 Jul 7. Epub 2020 Jul 7.

Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway.

Many diseases, including caries, chronic inflammatory diseases, diabetes, and obesity, are associated with uncontrolled sugar consumption. Artificial sweeteners are commonly used in food and pharmaceutical industries as sugar substitutes for the prevention of several dental and body diseases; they also have a favorable impact on body weight as they may help to restrict simple sugar consumption. Xylitol is a sugar alcohol that is commonly used as a sweetener. Read More

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http://dx.doi.org/10.1007/s00253-020-10708-7DOI Listing

Ileus Due to Iron Pills: A Case Report and Literature Report on the Importance of Stool Softeners.

Cureus 2020 Jun 1;12(6):e8392. Epub 2020 Jun 1.

Hospital Medicine, Geisinger Lewistown Hospital, Lewistown, USA.

Iron deficiency anemia is the leading cause of anemia in the U.S. and throughout the world. Read More

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http://dx.doi.org/10.7759/cureus.8392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331903PMC

[Anal tone: Physiology, clinical and instrumental characteristics].

Prog Urol 2020 Jul 4. Epub 2020 Jul 4.

Hôpital Tenon, Sorbonne université, GRC 001, GREEN groupe de recherche clinique en neuro-urologie, AP-HP, 75020 Paris, France.

Introduction: The anal tone allows the maintenance of anorectal continence. Its regulation depends on spinal segmental mechanisms under supra-sacral control.

Material And Methods: A systematic review was performed using Medline database, according to PRISMA methodology, using following keywords anal tone ; anal sphincter ; anorectal function ; reflex ; digital rectal examination. Read More

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http://dx.doi.org/10.1016/j.purol.2020.06.004DOI Listing

Potential effectiveness of Ospemifene on Detrusor Overactivity in patients with vaginal atrophy.

Maturitas 2020 Aug 11;138:58-61. Epub 2020 May 11.

Division of Gynecology and Obstetrics, Umberto I Hospital, Turin, Italy. Electronic address:

Objectives: To report the effects on the urinary function of ospemifene prescribed for vulvovaginal atrophy (VVA) in patients with overactive bladder (OAB) symptoms refractory to the first line of pharmacologic treatment with antimuscarinic or β3-agonists drugs. We also try to identify any predictors of response to the ospemifene treatment.

Study Design: Twenty-five patients with OAB confirmed by detrusor overactivity at urodynamics, refractory to first-line therapy for OAB, were enrolled for the study. Read More

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http://dx.doi.org/10.1016/j.maturitas.2020.05.001DOI Listing

The impact of overlapping functional dyspepsia, belching disorders and functional heartburn on anxiety, depression and quality of life of Chinese patients with irritable bowel syndrome.

BMC Gastroenterol 2020 Jul 6;20(1):209. Epub 2020 Jul 6.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, No. 95 Yongan Road, Beijing, 100050, China.

Background: Functional dyspepsia (FD), belching disorders (BD) and functional heartburn (FH) are the three most common upper functional gastrointestinal disorders (FGID) in IBS patients. FD is known to exert deleterious effects on health-related quality of life (HRQoL) and the psychological status of IBS patients; however, the impact of overlapping BD and FH on anxiety, depression and HRQoL of IBS patients remains unknown. This cross-sectional study was conducted to investigate the impact of overlapping FD, BD and FH on anxiety, depression and HRQoL in patients with IBS. Read More

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http://dx.doi.org/10.1186/s12876-020-01357-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336672PMC

Laxative metabolites from the leaves of Moringa oleifera.

J Agric Food Chem 2020 Jul 6. Epub 2020 Jul 6.

Three new flavonoids, quercetin-3-O-6-[methyl (S)-3-hydroxy-3 methylglutaroyl(1→6]-β-D-glucopyranoside (1), kaempferol-3-O-[ methyl (S)-3-hydroxy-3-methylglutaroyl (1→6)]-β-D-glucopyranoside (2), and quercetin-3-O-6-[(E)-4-methoxy-5-methylhexa-2,4-dienoatyl (1→6)]-β-D-glucopyranoside (3), and two new alkaloids, 5-dehydroxymethyl-pyrrolemarumine 4"-O-α-L-rhamnopyranoside (4) and N1-methyl-N2-((4-O-α-L-rhamnopyranoside)benzyl)oxalamide (5), together with forty-five known compounds (6-50) were isolated from the leaves of Moringa oleifera Lam. Among those compounds, 1-octacosanol (50), a straight-chain 28-carbon alcohol exhibited good activity against diphenoxylate-induced constipation in mice, which is obtained as a laxative constituent from the plant for the first time. In order to have an accurate understanding the content of compound 50, a quantification with GC-MS/MS was carried out. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c01564DOI Listing

Molecular Dynamics Simulations to Investigate How PZM21 Affects the Conformational State of the μ-Opioid Receptor Upon Activation.

Int J Mol Sci 2020 Jul 1;21(13). Epub 2020 Jul 1.

School of Pharmacy, Lanzhou University, Lanzhou 730000, China.

Opioid analgesics such as morphine have indispensable roles in analgesia. However, morphine use can elicit side effects such as respiratory depression and constipation. It has been reported that G protein-biased agonists as substitutes for classic opioid agonists can alleviate (or even eliminate) these side effects. Read More

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http://dx.doi.org/10.3390/ijms21134699DOI Listing

Astragaloside IV alleviates mouse slow transit constipation by modulating gut microbiota profile and promoting butyric acid generation.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Gut microbiota and short-chain fatty acids (SCFAs) are associated with the development of various human diseases. In this study, we examined the role of astragaloside IV in modulating mouse gut microbiota structure and the generation of SCFAs, as well as in slow transit constipation (STC). An STC model was established by treating mice with loperamide, in which the therapeutic effects of astragaloside IV were evaluated. Read More

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http://dx.doi.org/10.1111/jcmm.15586DOI Listing

The severity of symptoms is insufficient to predict major alterations to quality of life of patients with fecal incontinence or chronic constipation.

Int J Colorectal Dis 2020 Jul 5. Epub 2020 Jul 5.

Digestive Center, University Hospital of Nice, 151 route de Saint Antoine de Ginestière - CS 23079, 06202, Nice Cedex, France.

Purpose: Evaluate the impact of fecal incontinence (FI) and chronic constipation (CC) on the quality of life (QoL) in a large population and determine if a threshold of symptom scores was associated with alterations to QoL.

Methods: A total of 422 outpatients with FI (n = 186), CC (n = 186), and mixed FI-CC (n = 50) referred for anorectal manometry were included prospectively. All patients completed a set of questionnaires to evaluate the severity of FI and CC (respectively Jorge and Wexner and KESS scores) and their impact on QoL (Gastrointestinal Quality of Life Index (GIQLI)). Read More

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http://dx.doi.org/10.1007/s00384-020-03685-wDOI Listing

Health Disparities and Constipation Management among Pediatric Patients in the Emergency Department.

J Natl Med Assoc 2020 Jul 2. Epub 2020 Jul 2.

Baylor College of Medicine, Center of Excellence in Health Equity, Training and Research, USA.

Introduction: Constipation is a common cause of abdominal pain in children. Prior studies have demonstrated that nearly half of the children with constipation receive enemas; however, studies regarding constipation management based on race and ethnicity have not been pursued. The goal of this investigation is to determine if demographic disparities namely, race and ethnicity and insurance status affect emergency department (ED) management of constipation and prescription of enema. Read More

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http://dx.doi.org/10.1016/j.jnma.2020.05.011DOI Listing

Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial.

Chin J Integr Med 2020 Jul 4. Epub 2020 Jul 4.

Persian Traditional Medicine, Faculty of Persian Traditional and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, 9177899191, Iran.

Objective: To evaluate the efficacy and safety of administration of the formulated Persian herbal syrup on improving the symptoms of patients with constipation-predominant irritable bowel syndrome (IBS-C).

Methods: This study was conducted in 70 patients with IBS-C, who were recruited from 3 medical centers in Mashhad, Iran, from November 2017 to August 2018. Seventy patients were randomly assigned to 2 groups including treatment and placebo groups by block randomization, 35 cases in each group. Read More

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http://dx.doi.org/10.1007/s11655-020-3267-4DOI Listing

Transdermal versus oral granisetron in controlling chemotherapy-induced nausea and vomiting: a meta-analysis.

Support Care Cancer 2020 Jul 4. Epub 2020 Jul 4.

Division of Medical Oncology, Department of Medicine, University of the Philippines - Philippine General Hospital, Taft Avenue, Ermita, Manila, Philippines.

Purpose: To compare the efficacy of transdermal granisetron versus oral granisetron in controlling chemotherapy-induced nausea and vomiting (CINV) in patients with cancer METHODS: Data sources were CENTRAL, MEDLINE, EMBASE, Clinicaltrials.gov , and Google Scholar. Inclusion criteria included randomized controlled trials comparing transdermal versus oral granisetron in patients with CINV. Read More

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http://dx.doi.org/10.1007/s00520-020-05611-wDOI Listing

Preventive effects of naldemedine, peripherally acting μ-opioid receptor antagonist, on morphine-induced nausea and vomiting in ferrets.

Life Sci 2020 Jul 2;257:118048. Epub 2020 Jul 2.

Department of Pharmacology, School of Pharmacy, Shonan University of Medical Sciences, Yokohama, Japan.

Aims: Naldemedine is a peripherally acting μ-opioid receptor antagonists (PAMORAs) indicated for the treatment of opioid-induced constipation (OIC). We investigated the preventive effect of naldemedine on morphine-induced nausea and vomiting in ferrets and conducted a pharmacokinetic/pharmacodynamic (PK/PD) analysis.

Main Methods: The antiemetic effect of naldemedine was evaluated as the frequency and time of retching (rhythmic abdominal contractile motion) and vomiting (throwing up vomit or similar reactions) caused by morphine in ferrets. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118048DOI Listing

Phase 1, First-in-Human Study of Futibatinib, a Highly Selective, Irreversible FGFR1-4 Inhibitor in Patients with Advanced Solid Tumors.

Ann Oncol 2020 Jul 2. Epub 2020 Jul 2.

Medical Oncology, Sarah Cannon Research Institute and Cancer Institute University College London, London, UK.

Background: Futibatinib is an oral, irreversible, highly selective fibroblast growth factor receptor (FGFR)1-4 inhibitor with potent preclinical activity against tumors harboring FGFR aberrations. This first-in-human, phase 1 dose-escalation trial (NCT02052778) evaluates the safety and pharmacokinetics/pharmacodynamics of futibatinib in advanced solid tumors.

Patients And Methods: Following a standard 3+3 dose-escalation design, eligible patients with advanced solid tumors refractory to standard therapies received 8-200 mg futibatinib thrice weekly (TIW) or 4-24 mg once daily (QD). Read More

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http://dx.doi.org/10.1016/j.annonc.2020.06.018DOI Listing

Gastrointestinal Alterations in Autism Spectrum Disorder: What Do We Know?

Neurosci Biobehav Rev 2020 Jul 1. Epub 2020 Jul 1.

CONEM Egypt Child Brain Research Group, National Research Centre, Giza, Egypt; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy; CONEM Scientific Secretary, Verona, Italy.

There is an emerging body of evidence associating children having autism spectrum disorder (ASD) with gastrointestinal (GI) symptoms, such as abdominal pain, chronic diarrhea, constipation, vomiting, gastroesophageal reflux, intestinal infections, and increased intestinal permeability. Moreover, in many studies, large differences in the composition of intestinal microbiota and metabolic products between ASD patients and controls were reported. Deepening the role and the biology of the gut microbiome may be fundamental to elucidate the onset of GI symptoms in ASD individuals and their etiopathogenetic causes. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2020.06.033DOI Listing

Benefits of risk-adapted and mould-specific antifungal prophylaxis in childhood leukaemia.

Br J Haematol 2020 Jul 4. Epub 2020 Jul 4.

Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria.

Fluconazole is one of the most commonly used drugs for antifungal prophylaxis in childhood leukaemia. However, its interaction with vincristine may induce neuropathy and the emergence of antifungal drug resistance contributes to substantial mortality caused by invasive fungal infections (IFIs). In a retrospective single-centre study, we compared tolerability and outcome of different antifungal prophylaxis strategies in 198 children with acute leukaemia (median age 5·3 years). Read More

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http://dx.doi.org/10.1111/bjh.16931DOI Listing

Opioids for breathlessness: a narrative review.

BMJ Support Palliat Care 2020 Jul 3. Epub 2020 Jul 3.

Wolfson Palliative Care Research Centre, University of Hull, Hull, Kingston upon Hull, UK.

Chronic breathlessness is a disabling and distressing condition for which there is a growing evidence base for a range of interventions. Non-pharmacological interventions are the mainstay of management and should be optimised prior to use of opioid medication. Opioids are being implemented variably in practice for chronic breathlessness. Read More

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http://dx.doi.org/10.1136/bmjspcare-2020-002314DOI Listing

Long-term Anatomical and Functional Results of Robot-Assisted Pelvic Floor Surgery for the Management of Multicompartment Prolapse: A Prospective Study.

Dis Colon Rectum 2020 Jun 24. Epub 2020 Jun 24.

Meander Medical Center, Department of Gynecology, Amersfoort, The Netherlands.

Background: Long-term data on robot-assisted sacrocolporectopexy for the treatment of multicompartment pelvic organ prolapse is scarce. With the rising prevalence of prolapse and increasing surgical repair, it is essential to evaluate long-term results.

Objective: To evaluate long-term functional and anatomic outcomes after sacrocolporectopexy. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001696DOI Listing

Cardiac tamponade due to primary hypothyroidism: acute management and approach to prevent recurrence-a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-5. Epub 2020 May 3.

Department of Cardiology, Osmania General Hospital, Hyderabad, Telangana, India.

Background: Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone, with iodine deficiency remains the foremost cause. It is more common in women with increasing incidence in the elderly. The manifestations of hypothyroidism results from the hypometabolism in the body at cellular level and affects all organs. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319808PMC

Rectal Lipoma in an Elderly Male: A Case Report.

Cureus 2020 May 30;12(5):e8366. Epub 2020 May 30.

First Department of Surgery, Saint George General Hospital of Chania, Chania, GRC.

Lipomas of the gastrointestinal tract are uncommon, benign non-epithelial tumors detected incidentally during surgery or endoscopy. Rectal lipomas are extremely rare. Patients may be asymptomatic or present with rectal bleeding, constipation, tenesmus and signs of intestinal obstruction. Read More

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http://dx.doi.org/10.7759/cureus.8366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325349PMC

Multi-institutional review of bowel management strategies in children with anorectal malformations.

J Pediatr Surg 2020 May 13. Epub 2020 May 13.

Division of Pediatric Surgery, Emory University School of Medicine and Children's Healthcare of Atlanta, 1405 Clifton Road NE, 3rd Floor, Tower 1, Pediatric Surgical Suite, Atlanta, Ga 30322, USA. Electronic address:

Background/rationale: To describe current bowel management program (BMP) strategies in anorectal malformation (ARM) patients based on patient-level predictors using data from a multi-institutional consortium.

Materials/methods: Patient bowel function and BMP were reviewed from Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) data. The PCPLC is comprised of multidisciplinary specialists researching colorectal and pelvic disorders. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.04.023DOI Listing

Progressive and accelerated weight and body fat loss in Parkinson's disease: A three-year prospective longitudinal study.

Parkinsonism Relat Disord 2020 Jun 20;77:28-35. Epub 2020 Jun 20.

Division of Neurology, Department of Medicine, and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Introduction: Although weight loss is common in Parkinson's disease (PD), longitudinal studies assessing weight and body composition changes are limited.

Methods: In this three-year longitudinal study, 125 subjects (77 PD patients and 48 spousal/sibling controls) underwent clinical, biochemical and body composition assessments using dual-energy X-ray absorptiometry.

Results: Patients were older than controls (65. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2020.06.015DOI Listing

Improving the utility of high-resolution manometry for the diagnosis of defecatory disorders in women with chronic constipation.

Neurogastroenterol Motil 2020 Jul 1:e13910. Epub 2020 Jul 1.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Background: We compared the utility of existing and modified versions of high-resolution manometry for diagnosing defecatory disorders (DD).

Methods: In 64 healthy and 136 constipated women, we compared left lateral (LL) and seated manometry, and analyzed with existing (ManoView™) and new methods, for discriminating between constipated patients with normal and prolonged rectal balloon expulsion time (BET). In both positions, the rectoanal gradient (RAG) and, for the new analysis, the pressure topography pattern during evacuation were used to discriminate between constipated patients without and with DD. Read More

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http://dx.doi.org/10.1111/nmo.13910DOI Listing

Rapid Screening and Identification of Chemical Constituents From Ophiopogon japonicus by High-Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry.

J Chromatogr Sci 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.

Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), which is named as "Maidong" in China, is widely used in traditional Chinese medicine for treating fever, cough, inflammation, epistaxis, constipation, respiratory disease and gastrointestinal disorders. However, the systematic analysis of chemical constituents of O. Read More

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http://dx.doi.org/10.1093/chromsci/bmaa029DOI Listing
July 2020
1.363 Impact Factor

Efficacy of Intravenous Acetaminophen as Adjunct Post-Operative Analgesic in Cardiac Surgery: A Retrospective Study.

Kans J Med 2020 25;13:143-146. Epub 2020 Jun 25.

University of Kansas School of Medicine-Wichita, Department of Surgery, Wichita, KS.

Introduction: The dose-dependent adverse events associated with post-operative opioid use may be reduced when opioids are used in conjunction with intravenous acetaminophen. The purpose of this study was to compare outcomes in median sternotomy patients receiving intravenous acetaminophen in addition to intravenous opioids versus intravenous opioids only.

Methods: A retrospective study was conducted on 122 adult patients undergoing median sternotomy at a regional tertiary-referral center. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324059PMC

Case 4: 1 Month of Constipation and Abdominal Pain in a 2-year-old Girl.

Pediatr Rev 2020 Jul;41(7):369-372

Department of Emergency and Transport Medicine, Children's Hospital Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1542/pir.2017-0228DOI Listing

Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease.

Nutrients 2020 06 29;12(7). Epub 2020 Jun 29.

Division of Nephrology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.

Chronic kidney disease (CKD) affects >10% of the adult population. Each year, approximately 120,000 Americans develop end-stage kidney disease and initiate dialysis, which is costly and associated with functional impairments, worse health-related quality of life, and high early-mortality rates, exceeding 20% in the first year. Recent declarations by the World Kidney Day and the U. Read More

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http://dx.doi.org/10.3390/nu12071931DOI Listing
June 2020
3.148 Impact Factor

PREVALENCE AND FACTORS ASSOCIATED WITH CONSTIPATION IN PREMENOPAUSAL WOMEN: A COMMUNITY-BASED STUDY.

Arq Gastroenterol 2020 Apr-Jun;57(2):188-192

Universidade Federal do Rio Grande do Norte, Faculdade de Ciências da Saúde de Trairi (FACISA), Santa Cruz, RN, Brasil.

Background: Intestinal constipation is characterized by problems related to evacuation, and presents high prevalence in the female gender. This condition has demonstrated negative effects on the development of daily activities, causing damage to the physical and emotional well-being of individuals who are diagnosed with it. Studies that investigate what health impairments intestinal constipation can cause are scarce in the literature. Read More

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http://dx.doi.org/10.1590/S0004-2803.202000000-36DOI Listing
January 2020

BOWEL FREQUENCY AND SYMPTOMS OF CONSTIPATION AND ITS RELATION WITH THE LEVEL OF PHYSICAL ACTIVITY IN PATIENTS WITH CHAGAS DISEASE.

Arq Gastroenterol 2020 Apr-Jun;57(2):161-166

Universidade Estadual de Maringá, Departamento de Ciências Básicas da Saúde, Parasitologia, Maringá, PR, Brasil.

Background: Intestinal constipation (IC) in patients with the digestive form of Chagas disease is one of the main reasons for seeking medical care. Population data indicate that the practice of physical activity improves gastrointestinal motility.

Objective: This study evaluated the bowel frequency and symptoms of constipation and their relationship with the level of physical activity in patients with and without Chagas disease. Read More

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http://dx.doi.org/10.1590/S0004-2803.202000000-30DOI Listing
December 2019

Giant Liver Hemangiomas: A Plea for Early Surgical Referral and Resection.

Case Rep Surg 2020 16;2020:5923787. Epub 2020 Jun 16.

School of Medicine and Hume-Lee Transplant Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

Hepatic hemangiomas are the most common benign hepatic tumor. Current guidelines recommend surveillance imaging and reserving surgical intervention for symptomatic patients with giant liver hemangiomas (>5 cm). We present the case of a patient with a rapidly enlarging giant hepatic hemangioma initially managed by surveillance. Read More

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http://dx.doi.org/10.1155/2020/5923787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315262PMC

Patients' perception about opioids and addiction in South Korea.

Korean J Pain 2020 Jul;33(3):234-244

Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, Seoul, Korea.

Background: Chronic pain affects approximately 22% of the world's population. Opioids can be useful in chronic pain management. However, some patients have negative perception of opioids. Read More

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http://dx.doi.org/10.3344/kjp.2020.33.3.234DOI Listing

Differential Impact of Gonadotropin-releasing Hormone Antagonist Versus Agonist on Clinical Safety and Oncologic Outcomes on Patients with Metastatic Prostate Cancer: A Meta-analysis of Randomized Controlled Trials.

Eur Urol 2020 Jun 27. Epub 2020 Jun 27.

Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan; Department of Urology, Medical University of Vienna, Vienna, Austria; Department of Urology, Weill Cornell Medical College, New York, NY, USA; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria; Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia. Electronic address:

Context: Androgen deprivation therapy is the mainstay treatment of metastatic prostate cancer, achieved mainly by gonadotropin-releasing hormone (GnRH) agonists or antagonists.

Objective: To investigate the differential impact of GnRH agonists and antagonists on clinical safety and oncologic outcomes.

Evidence Acquisition: This meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Read More

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http://dx.doi.org/10.1016/j.eururo.2020.06.002DOI Listing

[The Efficacy of Fesoterodine Switched from Solifenacin for Overactive Bladder Patients].

Hinyokika Kiyo 2020 Jun;66(6):165-170

Ugo Municipal Hospital.

We investigated the efficacy of Fesoterodine, in 51 patients who did not respond to treatment with Solifenacin from January 2017 to December 2018. We assessed the overactive bladder symptom score (OABSS), thirst, constipation, and residual urine at baseline, as well as at 3 and 6 months from the start of drug administration. The mean age of the patients was 83. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_6_165DOI Listing

[Progress in diagnosis and treatment of functional constipation in children].

Authors:
T Yang M Z Jiang

Zhonghua Er Ke Za Zhi 2020 Jul;58(7):611-614

Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou 310052, China.

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http://dx.doi.org/10.3760/cma.j.cn112140-20200203-00059DOI Listing

Symptom Profiles of Latina Breast Cancer Survivors: A Latent Class Analysis.

Nurs Res 2020 Jul/Aug;69(4):264-271

Tracy E. Crane, PhD, RDN, is Assistant Professor, University of Arizona, Tucson. Terry A. Badger, PhD, RN, PMHCNS-BC, FAAN, is Professor, University of Arizona, Tucson. Alla Sikorskii, PhD, is Professor, Michigan State University, East Lansing. Chris Segrin, PhD, is Professor, University of Arizona, Tucson. Chiu-Hsieh Hsu, PhD, is Professor, University of Arizona, Tucson. Anne G. Rosenfeld, PhD, RN, CNS, FAHA, FAAN, is Professor, University of Arizona, Tucson.

Background: Symptom research among Latinas with breast cancer is limited-especially as it relates to multiple co-occurring symptoms.

Objective: The aim of the study was to identify subgroups (latent classes) of Latinas who have distinct symptom profiles while receiving radiation, chemotherapy, and/or hormonal therapy for breast cancer.

Methods: This secondary analysis included intake data from three randomized trials of supportive care psychosocial interventions for Latinas treated for breast cancer (n = 290). Read More

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http://dx.doi.org/10.1097/NNR.0000000000000434DOI Listing

Rising prevalence of colonic diverticulosis in a westernized multi-ethnic Asian community.

J Gastroenterol Hepatol 2020 Jun 29. Epub 2020 Jun 29.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Background And Aim: Singapore is a multi-ethnic country that has undergone rapid development over the last few decades, with increasing influence of western culture, and faces an aging population. Previously, a varying prevalence of colonic diverticulosis (CD) was reported by a few small studies. This study aims to evaluate the prevalence of CD in Singapore and identify associations with common gastrointestinal symptoms and risk factors. Read More

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http://dx.doi.org/10.1111/jgh.15165DOI Listing

Outcomes after enterostomies in children with and without motility disorders: A description and comparison of postoperative complications.

J Pediatr Surg 2020 May 28. Epub 2020 May 28.

Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Purpose: To provide an overview of complications after ileostomy or colostomy procedures in children, and to compare outcomes between patients with gastrointestinal motility disorders (i.e. functional constipation, Hirschsprung's disease, pediatric intestinal pseudo-obstruction (PIPO)) and children without motility disorders (including necrotizing enterocolitis, anorectal malformation and inflammatory bowel disease). Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.05.027DOI Listing

Stool frequency and form and gastrointestinal symptoms differ by day of the menstrual cycle in healthy adult women taking oral contraceptives: a prospective observational study.

BMC Womens Health 2020 Jun 29;20(1):136. Epub 2020 Jun 29.

Food Science and Human Nutrition Department, University of Florida, 572 Newell Dr, Gainsville, FL, 32611, USA.

Background: Little is known about how the menstrual cycle affects gastrointestinal function and self-reported stress in young, healthy women taking oral contraceptives (OC). This study prospectively characterized gastrointestinal function and symptoms on each day throughout the menstrual cycle.

Methods: Healthy women aged 18-35 years (n = 78) who took OC participated in the 5-week observational study. Read More

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http://dx.doi.org/10.1186/s12905-020-01000-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325082PMC

Severe constipation as the first clinical manifestation in multiple endocrine neoplasia type 2B: a case report and literature review.

BMC Pediatr 2020 Jun 29;20(1):318. Epub 2020 Jun 29.

Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: The occurrence of multiple endocrine neoplasia type 2B (MEN2B) in Asians is very rare. In particular, patients with intractable constipation as the main clinical manifestation are even rarer. Atypical clinical manifestations are likely to lead to a diagnostic delay. Read More

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http://dx.doi.org/10.1186/s12887-020-02224-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322851PMC

Ileocecal Valve Removal Reverses the Constipating Effects of Loperamide in Rats.

J Surg Res 2020 Jun 27;255:371-377. Epub 2020 Jun 27.

University Research Institute of Maternal & Child Health and Precision Medicine, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

Background: Previous evidence associating ileocecal valve removal (ICVR) with a reduced risk of fecal impaction of the ileocecum in cystic fibrosis indicated possible benefits from ileocecal valve loss in disorders with inhibited proximal colon transit caused by fecal dehydration and hypoperistalsis. We aimed to investigate the ability of ICVR in reversing fecal impaction in a loperamide-induced model of a similar pattern of inhibited proximal colon transit in rats.

Materials And Methods: Thirty pubertal Sprague-Dawley rats were rendered constipated with subcutaneous loperamide treatment (1 mg/kg/d) for 7 d. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.002DOI Listing