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Schizophr Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Psychological Medicine, University of Otago, Wellington, New Zealand; Capital and Coast District Health Board, Wellington, New Zealand. Electronic address:

BMC Palliat Care 2020 Jul 10;19(1):103. Epub 2020 Jul 10.

Institut Català d'Oncologia (ICO), Girona, Spain.

Background: Despite advances in surgery, radiotherapy, and chemotherapy, pancreatic adenocarcinoma often progresses rapidly and causes death. The physical decline of these patients is expected to impact their quality of life (QoL). Therefore, in addition to objective measures of effectiveness, the evaluation of health-related QoL should be considered a matter of major concern when assessing therapy outcomes. Read More

Curr Top Med Chem 2020 Jul 9. Epub 2020 Jul 9.

Project Management Department, Global Development Division, Osaka. Japan.

Opioids are widely used for pain management in moderate-to-severe pain. However, opioids are associated with adverse events, such as constipation and emesis/vomiting. To reduce these undesired effects, a structure-activity relationship study of morphinan derivatives was conducted, and a promising lead compound with inhibitory effects on opioid receptors was obtained. Read More

J Pediatr 2020 Jul 6. Epub 2020 Jul 6.

Infant Botulism Treatment and Prevention Program, California Department of Public Health, 850 Marina Bay Parkway Richmond, CA 94804. Electronic address:

Objective: To ascertain possible risk factors for infant botulism, the intestinal infectious form of human botulism, in the years immediately following its initial recognition in California in 1976..

Study Design: Parents of 159 California laboratory-confirmed cases of infant botulism from 1976-1983 and 318 healthy controls were interviewed using a comprehensive (>300 factors) questionnaire. Read More

JMIR Public Health Surveill 2020 Jul 8. Epub 2020 Jul 8.

Department of Gastroenterology and Hepatology, Weill Cornell Medicine New York NY, 1305 York Ave4th floor, New York, US.

Background: The coronavirus disease 2019 (COVID-19) is a novel viral illness that has rapidly spread worldwide. While the disease primarily presents as a respiratory illness, gastrointestinal symptoms such as diarrhea have been reported in up to a third of confirmed cases, and patients may have mild symptoms that do not prompt medical attention. Internet-based infodemiology approaches offer an approach to studying symptoms at a population level, even in patients who do not seek medical care. Read More

Pain 2020 Jun 24. Epub 2020 Jun 24.

Department of Anesthesiology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.

Currently, opioids targeting mu-opioid receptors (MOR) are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a compound that does not evoke central or intestinal side effects due to its selective activation of MOR at low pH in peripheral injured tissues. Read More

Am J Gastroenterol 2020 Jun 24. Epub 2020 Jun 24.

Middleburg Consultants, Takoma Park, Maryland, USA.

Introduction: Previous, small studies have suggested that ondansetron has beneficial effects in diarrhea-predominant irritable bowel syndrome (IBS-D). This randomized, double-blind study evaluated the efficacy and safety of daily 12 mg RHB-102, an investigational bimodal release ondansetron tablet, in IBS-D.

Methods: Men and women with IBS-D by the Rome III criteria, Bristol Stool Scale ≥6 on 2 or more days weekly, and average daily worst pain intensity ≥3/10 were randomized 60:40 to RHB-102 or placebo once daily for 8 weeks. Read More

Appl Microbiol Biotechnol 2020 Jul 7. Epub 2020 Jul 7.

Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway.

Many diseases, including caries, chronic inflammatory diseases, diabetes, and obesity, are associated with uncontrolled sugar consumption. Artificial sweeteners are commonly used in food and pharmaceutical industries as sugar substitutes for the prevention of several dental and body diseases; they also have a favorable impact on body weight as they may help to restrict simple sugar consumption. Xylitol is a sugar alcohol that is commonly used as a sweetener. Read More

Cureus 2020 Jun 1;12(6):e8392. Epub 2020 Jun 1.

Hospital Medicine, Geisinger Lewistown Hospital, Lewistown, USA.

Iron deficiency anemia is the leading cause of anemia in the U.S. and throughout the world. Read More

Prog Urol 2020 Jul 4. Epub 2020 Jul 4.

Hôpital Tenon, Sorbonne université, GRC 001, GREEN groupe de recherche clinique en neuro-urologie, AP-HP, 75020 Paris, France.

Introduction: The anal tone allows the maintenance of anorectal continence. Its regulation depends on spinal segmental mechanisms under supra-sacral control.

Material And Methods: A systematic review was performed using Medline database, according to PRISMA methodology, using following keywords anal tone ; anal sphincter ; anorectal function ; reflex ; digital rectal examination. Read More

Maturitas 2020 Aug 11;138:58-61. Epub 2020 May 11.

Division of Gynecology and Obstetrics, Umberto I Hospital, Turin, Italy. Electronic address:

Objectives: To report the effects on the urinary function of ospemifene prescribed for vulvovaginal atrophy (VVA) in patients with overactive bladder (OAB) symptoms refractory to the first line of pharmacologic treatment with antimuscarinic or β3-agonists drugs. We also try to identify any predictors of response to the ospemifene treatment.

Study Design: Twenty-five patients with OAB confirmed by detrusor overactivity at urodynamics, refractory to first-line therapy for OAB, were enrolled for the study. Read More

BMC Gastroenterol 2020 Jul 6;20(1):209. Epub 2020 Jul 6.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, No. 95 Yongan Road, Beijing, 100050, China.

Background: Functional dyspepsia (FD), belching disorders (BD) and functional heartburn (FH) are the three most common upper functional gastrointestinal disorders (FGID) in IBS patients. FD is known to exert deleterious effects on health-related quality of life (HRQoL) and the psychological status of IBS patients; however, the impact of overlapping BD and FH on anxiety, depression and HRQoL of IBS patients remains unknown. This cross-sectional study was conducted to investigate the impact of overlapping FD, BD and FH on anxiety, depression and HRQoL in patients with IBS. Read More

J Agric Food Chem 2020 Jul 6. Epub 2020 Jul 6.

Three new flavonoids, quercetin-3-O-6-[methyl (S)-3-hydroxy-3 methylglutaroyl(1→6]-β-D-glucopyranoside (1), kaempferol-3-O-[ methyl (S)-3-hydroxy-3-methylglutaroyl (1→6)]-β-D-glucopyranoside (2), and quercetin-3-O-6-[(E)-4-methoxy-5-methylhexa-2,4-dienoatyl (1→6)]-β-D-glucopyranoside (3), and two new alkaloids, 5-dehydroxymethyl-pyrrolemarumine 4"-O-α-L-rhamnopyranoside (4) and N1-methyl-N2-((4-O-α-L-rhamnopyranoside)benzyl)oxalamide (5), together with forty-five known compounds (6-50) were isolated from the leaves of Moringa oleifera Lam. Among those compounds, 1-octacosanol (50), a straight-chain 28-carbon alcohol exhibited good activity against diphenoxylate-induced constipation in mice, which is obtained as a laxative constituent from the plant for the first time. In order to have an accurate understanding the content of compound 50, a quantification with GC-MS/MS was carried out. Read More

Int J Mol Sci 2020 Jul 1;21(13). Epub 2020 Jul 1.

School of Pharmacy, Lanzhou University, Lanzhou 730000, China.

Opioid analgesics such as morphine have indispensable roles in analgesia. However, morphine use can elicit side effects such as respiratory depression and constipation. It has been reported that G protein-biased agonists as substitutes for classic opioid agonists can alleviate (or even eliminate) these side effects. Read More

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Gut microbiota and short-chain fatty acids (SCFAs) are associated with the development of various human diseases. In this study, we examined the role of astragaloside IV in modulating mouse gut microbiota structure and the generation of SCFAs, as well as in slow transit constipation (STC). An STC model was established by treating mice with loperamide, in which the therapeutic effects of astragaloside IV were evaluated. Read More

Int J Colorectal Dis 2020 Jul 5. Epub 2020 Jul 5.

Digestive Center, University Hospital of Nice, 151 route de Saint Antoine de Ginestière - CS 23079, 06202, Nice Cedex, France.

Purpose: Evaluate the impact of fecal incontinence (FI) and chronic constipation (CC) on the quality of life (QoL) in a large population and determine if a threshold of symptom scores was associated with alterations to QoL.

Methods: A total of 422 outpatients with FI (n = 186), CC (n = 186), and mixed FI-CC (n = 50) referred for anorectal manometry were included prospectively. All patients completed a set of questionnaires to evaluate the severity of FI and CC (respectively Jorge and Wexner and KESS scores) and their impact on QoL (Gastrointestinal Quality of Life Index (GIQLI)). Read More

J Natl Med Assoc 2020 Jul 2. Epub 2020 Jul 2.

Baylor College of Medicine, Center of Excellence in Health Equity, Training and Research, USA.

Introduction: Constipation is a common cause of abdominal pain in children. Prior studies have demonstrated that nearly half of the children with constipation receive enemas; however, studies regarding constipation management based on race and ethnicity have not been pursued. The goal of this investigation is to determine if demographic disparities namely, race and ethnicity and insurance status affect emergency department (ED) management of constipation and prescription of enema. Read More

Chin J Integr Med 2020 Jul 4. Epub 2020 Jul 4.

Persian Traditional Medicine, Faculty of Persian Traditional and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, 9177899191, Iran.

Objective: To evaluate the efficacy and safety of administration of the formulated Persian herbal syrup on improving the symptoms of patients with constipation-predominant irritable bowel syndrome (IBS-C).

Methods: This study was conducted in 70 patients with IBS-C, who were recruited from 3 medical centers in Mashhad, Iran, from November 2017 to August 2018. Seventy patients were randomly assigned to 2 groups including treatment and placebo groups by block randomization, 35 cases in each group. Read More

Support Care Cancer 2020 Jul 4. Epub 2020 Jul 4.

Division of Medical Oncology, Department of Medicine, University of the Philippines - Philippine General Hospital, Taft Avenue, Ermita, Manila, Philippines.

Purpose: To compare the efficacy of transdermal granisetron versus oral granisetron in controlling chemotherapy-induced nausea and vomiting (CINV) in patients with cancer METHODS: Data sources were CENTRAL, MEDLINE, EMBASE, Clinicaltrials.gov , and Google Scholar. Inclusion criteria included randomized controlled trials comparing transdermal versus oral granisetron in patients with CINV. Read More

Life Sci 2020 Jul 2;257:118048. Epub 2020 Jul 2.

Department of Pharmacology, School of Pharmacy, Shonan University of Medical Sciences, Yokohama, Japan.

Aims: Naldemedine is a peripherally acting μ-opioid receptor antagonists (PAMORAs) indicated for the treatment of opioid-induced constipation (OIC). We investigated the preventive effect of naldemedine on morphine-induced nausea and vomiting in ferrets and conducted a pharmacokinetic/pharmacodynamic (PK/PD) analysis.

Main Methods: The antiemetic effect of naldemedine was evaluated as the frequency and time of retching (rhythmic abdominal contractile motion) and vomiting (throwing up vomit or similar reactions) caused by morphine in ferrets. Read More

Ann Oncol 2020 Jul 2. Epub 2020 Jul 2.

Medical Oncology, Sarah Cannon Research Institute and Cancer Institute University College London, London, UK.

Background: Futibatinib is an oral, irreversible, highly selective fibroblast growth factor receptor (FGFR)1-4 inhibitor with potent preclinical activity against tumors harboring FGFR aberrations. This first-in-human, phase 1 dose-escalation trial (NCT02052778) evaluates the safety and pharmacokinetics/pharmacodynamics of futibatinib in advanced solid tumors.

Patients And Methods: Following a standard 3+3 dose-escalation design, eligible patients with advanced solid tumors refractory to standard therapies received 8-200 mg futibatinib thrice weekly (TIW) or 4-24 mg once daily (QD). Read More

Neurosci Biobehav Rev 2020 Jul 1. Epub 2020 Jul 1.

CONEM Egypt Child Brain Research Group, National Research Centre, Giza, Egypt; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy; CONEM Scientific Secretary, Verona, Italy.

There is an emerging body of evidence associating children having autism spectrum disorder (ASD) with gastrointestinal (GI) symptoms, such as abdominal pain, chronic diarrhea, constipation, vomiting, gastroesophageal reflux, intestinal infections, and increased intestinal permeability. Moreover, in many studies, large differences in the composition of intestinal microbiota and metabolic products between ASD patients and controls were reported. Deepening the role and the biology of the gut microbiome may be fundamental to elucidate the onset of GI symptoms in ASD individuals and their etiopathogenetic causes. Read More

Br J Haematol 2020 Jul 4. Epub 2020 Jul 4.

Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria.

Fluconazole is one of the most commonly used drugs for antifungal prophylaxis in childhood leukaemia. However, its interaction with vincristine may induce neuropathy and the emergence of antifungal drug resistance contributes to substantial mortality caused by invasive fungal infections (IFIs). In a retrospective single-centre study, we compared tolerability and outcome of different antifungal prophylaxis strategies in 198 children with acute leukaemia (median age 5·3 years). Read More

BMJ Support Palliat Care 2020 Jul 3. Epub 2020 Jul 3.

Wolfson Palliative Care Research Centre, University of Hull, Hull, Kingston upon Hull, UK.

Chronic breathlessness is a disabling and distressing condition for which there is a growing evidence base for a range of interventions. Non-pharmacological interventions are the mainstay of management and should be optimised prior to use of opioid medication. Opioids are being implemented variably in practice for chronic breathlessness. Read More

Dis Colon Rectum 2020 Jun 24. Epub 2020 Jun 24.

Meander Medical Center, Department of Gynecology, Amersfoort, The Netherlands.

Background: Long-term data on robot-assisted sacrocolporectopexy for the treatment of multicompartment pelvic organ prolapse is scarce. With the rising prevalence of prolapse and increasing surgical repair, it is essential to evaluate long-term results.

Objective: To evaluate long-term functional and anatomic outcomes after sacrocolporectopexy. Read More

Eur Heart J Case Rep 2020 Jun 3;4(3):1-5. Epub 2020 May 3.

Department of Cardiology, Osmania General Hospital, Hyderabad, Telangana, India.

Background: Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone, with iodine deficiency remains the foremost cause. It is more common in women with increasing incidence in the elderly. The manifestations of hypothyroidism results from the hypometabolism in the body at cellular level and affects all organs. Read More

Cureus 2020 May 30;12(5):e8366. Epub 2020 May 30.

First Department of Surgery, Saint George General Hospital of Chania, Chania, GRC.

Lipomas of the gastrointestinal tract are uncommon, benign non-epithelial tumors detected incidentally during surgery or endoscopy. Rectal lipomas are extremely rare. Patients may be asymptomatic or present with rectal bleeding, constipation, tenesmus and signs of intestinal obstruction. Read More

J Pediatr Surg 2020 May 13. Epub 2020 May 13.

Division of Pediatric Surgery, Emory University School of Medicine and Children's Healthcare of Atlanta, 1405 Clifton Road NE, 3rd Floor, Tower 1, Pediatric Surgical Suite, Atlanta, Ga 30322, USA. Electronic address:

Background/rationale: To describe current bowel management program (BMP) strategies in anorectal malformation (ARM) patients based on patient-level predictors using data from a multi-institutional consortium.

Materials/methods: Patient bowel function and BMP were reviewed from Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) data. The PCPLC is comprised of multidisciplinary specialists researching colorectal and pelvic disorders. Read More

Parkinsonism Relat Disord 2020 Jun 20;77:28-35. Epub 2020 Jun 20.

Division of Neurology, Department of Medicine, and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Introduction: Although weight loss is common in Parkinson's disease (PD), longitudinal studies assessing weight and body composition changes are limited.

Methods: In this three-year longitudinal study, 125 subjects (77 PD patients and 48 spousal/sibling controls) underwent clinical, biochemical and body composition assessments using dual-energy X-ray absorptiometry.

Results: Patients were older than controls (65. Read More

Neurogastroenterol Motil 2020 Jul 1:e13910. Epub 2020 Jul 1.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Background: We compared the utility of existing and modified versions of high-resolution manometry for diagnosing defecatory disorders (DD).

Methods: In 64 healthy and 136 constipated women, we compared left lateral (LL) and seated manometry, and analyzed with existing (ManoView™) and new methods, for discriminating between constipated patients with normal and prolonged rectal balloon expulsion time (BET). In both positions, the rectoanal gradient (RAG) and, for the new analysis, the pressure topography pattern during evacuation were used to discriminate between constipated patients without and with DD. Read More

J Chromatogr Sci 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.

Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), which is named as "Maidong" in China, is widely used in traditional Chinese medicine for treating fever, cough, inflammation, epistaxis, constipation, respiratory disease and gastrointestinal disorders. However, the systematic analysis of chemical constituents of O. Read More

Kans J Med 2020 25;13:143-146. Epub 2020 Jun 25.

University of Kansas School of Medicine-Wichita, Department of Surgery, Wichita, KS.

Introduction: The dose-dependent adverse events associated with post-operative opioid use may be reduced when opioids are used in conjunction with intravenous acetaminophen. The purpose of this study was to compare outcomes in median sternotomy patients receiving intravenous acetaminophen in addition to intravenous opioids versus intravenous opioids only.

Methods: A retrospective study was conducted on 122 adult patients undergoing median sternotomy at a regional tertiary-referral center. Read More

Pediatr Rev 2020 Jul;41(7):369-372

Department of Emergency and Transport Medicine, Children's Hospital Los Angeles, Los Angeles, CA.

Nutrients 2020 06 29;12(7). Epub 2020 Jun 29.

Division of Nephrology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.

Chronic kidney disease (CKD) affects >10% of the adult population. Each year, approximately 120,000 Americans develop end-stage kidney disease and initiate dialysis, which is costly and associated with functional impairments, worse health-related quality of life, and high early-mortality rates, exceeding 20% in the first year. Recent declarations by the World Kidney Day and the U. Read More

Arq Gastroenterol 2020 Apr-Jun;57(2):188-192

Universidade Federal do Rio Grande do Norte, Faculdade de Ciências da Saúde de Trairi (FACISA), Santa Cruz, RN, Brasil.

Background: Intestinal constipation is characterized by problems related to evacuation, and presents high prevalence in the female gender. This condition has demonstrated negative effects on the development of daily activities, causing damage to the physical and emotional well-being of individuals who are diagnosed with it. Studies that investigate what health impairments intestinal constipation can cause are scarce in the literature. Read More

Arq Gastroenterol 2020 Apr-Jun;57(2):161-166

Universidade Estadual de Maringá, Departamento de Ciências Básicas da Saúde, Parasitologia, Maringá, PR, Brasil.

Background: Intestinal constipation (IC) in patients with the digestive form of Chagas disease is one of the main reasons for seeking medical care. Population data indicate that the practice of physical activity improves gastrointestinal motility.

Objective: This study evaluated the bowel frequency and symptoms of constipation and their relationship with the level of physical activity in patients with and without Chagas disease. Read More

Case Rep Surg 2020 16;2020:5923787. Epub 2020 Jun 16.

School of Medicine and Hume-Lee Transplant Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

Hepatic hemangiomas are the most common benign hepatic tumor. Current guidelines recommend surveillance imaging and reserving surgical intervention for symptomatic patients with giant liver hemangiomas (>5 cm). We present the case of a patient with a rapidly enlarging giant hepatic hemangioma initially managed by surveillance. Read More

Korean J Pain 2020 Jul;33(3):234-244

Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, Seoul, Korea.

Background: Chronic pain affects approximately 22% of the world's population. Opioids can be useful in chronic pain management. However, some patients have negative perception of opioids. Read More

Eur Urol 2020 Jun 27. Epub 2020 Jun 27.

Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan; Department of Urology, Medical University of Vienna, Vienna, Austria; Department of Urology, Weill Cornell Medical College, New York, NY, USA; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria; Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia. Electronic address:

Context: Androgen deprivation therapy is the mainstay treatment of metastatic prostate cancer, achieved mainly by gonadotropin-releasing hormone (GnRH) agonists or antagonists.

Objective: To investigate the differential impact of GnRH agonists and antagonists on clinical safety and oncologic outcomes.

Evidence Acquisition: This meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Read More

Hinyokika Kiyo 2020 Jun;66(6):165-170

Ugo Municipal Hospital.

We investigated the efficacy of Fesoterodine, in 51 patients who did not respond to treatment with Solifenacin from January 2017 to December 2018. We assessed the overactive bladder symptom score (OABSS), thirst, constipation, and residual urine at baseline, as well as at 3 and 6 months from the start of drug administration. The mean age of the patients was 83. Read More

Zhonghua Er Ke Za Zhi 2020 Jul;58(7):611-614

Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou 310052, China.

Nurs Res 2020 Jul/Aug;69(4):264-271

Tracy E. Crane, PhD, RDN, is Assistant Professor, University of Arizona, Tucson. Terry A. Badger, PhD, RN, PMHCNS-BC, FAAN, is Professor, University of Arizona, Tucson. Alla Sikorskii, PhD, is Professor, Michigan State University, East Lansing. Chris Segrin, PhD, is Professor, University of Arizona, Tucson. Chiu-Hsieh Hsu, PhD, is Professor, University of Arizona, Tucson. Anne G. Rosenfeld, PhD, RN, CNS, FAHA, FAAN, is Professor, University of Arizona, Tucson.

Background: Symptom research among Latinas with breast cancer is limited-especially as it relates to multiple co-occurring symptoms.

Objective: The aim of the study was to identify subgroups (latent classes) of Latinas who have distinct symptom profiles while receiving radiation, chemotherapy, and/or hormonal therapy for breast cancer.

Methods: This secondary analysis included intake data from three randomized trials of supportive care psychosocial interventions for Latinas treated for breast cancer (n = 290). Read More

J Gastroenterol Hepatol 2020 Jun 29. Epub 2020 Jun 29.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Background And Aim: Singapore is a multi-ethnic country that has undergone rapid development over the last few decades, with increasing influence of western culture, and faces an aging population. Previously, a varying prevalence of colonic diverticulosis (CD) was reported by a few small studies. This study aims to evaluate the prevalence of CD in Singapore and identify associations with common gastrointestinal symptoms and risk factors. Read More

J Pediatr Surg 2020 May 28. Epub 2020 May 28.

Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Purpose: To provide an overview of complications after ileostomy or colostomy procedures in children, and to compare outcomes between patients with gastrointestinal motility disorders (i.e. functional constipation, Hirschsprung's disease, pediatric intestinal pseudo-obstruction (PIPO)) and children without motility disorders (including necrotizing enterocolitis, anorectal malformation and inflammatory bowel disease). Read More

BMC Womens Health 2020 Jun 29;20(1):136. Epub 2020 Jun 29.

Food Science and Human Nutrition Department, University of Florida, 572 Newell Dr, Gainsville, FL, 32611, USA.

Background: Little is known about how the menstrual cycle affects gastrointestinal function and self-reported stress in young, healthy women taking oral contraceptives (OC). This study prospectively characterized gastrointestinal function and symptoms on each day throughout the menstrual cycle.

Methods: Healthy women aged 18-35 years (n = 78) who took OC participated in the 5-week observational study. Read More

BMC Pediatr 2020 Jun 29;20(1):318. Epub 2020 Jun 29.

Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: The occurrence of multiple endocrine neoplasia type 2B (MEN2B) in Asians is very rare. In particular, patients with intractable constipation as the main clinical manifestation are even rarer. Atypical clinical manifestations are likely to lead to a diagnostic delay. Read More

J Surg Res 2020 Jun 27;255:371-377. Epub 2020 Jun 27.

University Research Institute of Maternal & Child Health and Precision Medicine, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

Background: Previous evidence associating ileocecal valve removal (ICVR) with a reduced risk of fecal impaction of the ileocecum in cystic fibrosis indicated possible benefits from ileocecal valve loss in disorders with inhibited proximal colon transit caused by fecal dehydration and hypoperistalsis. We aimed to investigate the ability of ICVR in reversing fecal impaction in a loperamide-induced model of a similar pattern of inhibited proximal colon transit in rats.

Materials And Methods: Thirty pubertal Sprague-Dawley rats were rendered constipated with subcutaneous loperamide treatment (1 mg/kg/d) for 7 d. Read More