79,302 results match your criteria Connective Tissue Research [Journal]


Biomaterial-induced multinucleated giant cells express proinflammatory signaling molecules: A histological study in humans.

J Biomed Mater Res A 2018 Dec 13. Epub 2018 Dec 13.

Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab, University Hospital Frankfurt Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

The biomaterials physicochemical characteristics influence their cellular reaction, degradation and regenerative capacities. Macrophages and multinucleated giant cells (MNGCs) are observed in the augmentation area of biomaterials. This study, for the first time, evaluated the polarization pattern of macrophages and MNGCs in response to two different bone substitute materials (synthetic bone substitute material (SBSM) = NanoBone® vs. Read More

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December 2018
1 Read

Post-infectious bronchiolitis obliterans.

Pediatr Pulmonol 2018 Dec 12. Epub 2018 Dec 12.

Centro Respiratorio, Hospital de Niños "Dr. Ricardo Gutiérrez", Buenos Aires, Argentina.

Bronchiolitis obliterans is a rare and severe chronic lung disease resulting from a lower respiratory tract lesion. It may occur after a bone marrow or lung transplantation, infectious diseases, or less frequently after inhaling toxic substances or after connective tissue diseases. Pathology, pathogenesis, and molecular biology, as well as the best treatment of bronchiolitis obliterans, remain the subject of ongoing research. Read More

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December 2018

Polyautoimmunity in rheumatological conditions.

Int J Rheum Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Co-occurrence of autoimmune diseases (ADs) within an individual is postulated to be a frequent phenomenon in rheumatic diseases. Similar clinical signs and symptoms, pathophysiological mechanisms, genetic factors within autoimmune diseases and aggregation of diverse ADs within families sustain the theory of shared pathogenesis of several ADs (autoimmune tautology). Polyautoimmunity (PA) is defined as the presence of more than one autoimmune disease in a single patient. Read More

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December 2018

A biallelic truncating AEBP1 variant causes connective tissue disorder in two siblings.

Am J Med Genet A 2018 Dec 11. Epub 2018 Dec 11.

Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Biallelic variants in the AEBP1 gene cause a novel autosomal-recessive connective tissue disorder (CTD) reminiscent of Ehlers-Danlos Syndrome (EDS). The four previously reported individuals show considerable clinical variability. Unbiased high-throughput sequencing enables the rapid identification of additional cases for such rare entities. Read More

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December 2018

The Twelve Cranial Nerves of Christmas: Mnemonics, rhyme, and anatomy - seeing the lighter side.

Anat Sci Educ 2018 Dec 11. Epub 2018 Dec 11.

Centre for Learning Anatomical Sciences, University of Southampton, Southampton, United Kingdom.

Anatomy, has in history, been linked to helpful ways to remember structures, branches of nerves, structures passing through foramina et cetera. Scalp is even a mnemonic in itself (Skin, Connective tissue, Aponeurosis, Loose areolar tissue, Pericranium). There has been concern by some educators that using mnemonics or rhymes promotes a surface approach to learning and is unhelpful in establishing long term and meaningful deep learning. Read More

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December 2018

High Dose Prednisolone Lowers Plasma Glycated Albumin Levels Compared to Actual Glycemic Control: A Retrospective Observational Study.

Diabetes Ther 2018 Dec 13. Epub 2018 Dec 13.

Department of Diabetes and Endocrinology, Graduate School of Medicine, Gifu University, Gifu, 501-1194, Japan.

Introduction: Glycated hemoglobin (A1c) and glycated albumin (GA) are often used as indicators of glycemic control. In this study, we determined whether prednisolone (PSL) administration lowers plasma GA.

Methods: We investigated the factors affecting GA using multivariate analysis in 48 subjects with connective tissue diseases (CTDs). Read More

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December 2018
2 Reads

Evaluation of mast cells in oral premalignant and malignant lesions: A histochemical study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

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December 2018

Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity.

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan-Jinbo Joint Research Center, Fudan University, Shanghai, 200302, China. Electronic address:

Collagen is one of the most abundant and important proteins in the human body. Human collagen type III (hCOL3A1) belongs to the fibril-forming collagens and is widely distributed in extensible connective tissue like skin, internal organs, or the vascular system. It plays key roles in wound healing, collagen fibrillogenesis, and normal cardiovascular development in human. Read More

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December 2018

Autoimmune interstitial lung disease in Latin-America.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Department of Research, Hospital Privado de Comunidad, Mar del Plata, Argentina.

Information about the prognosis and natural history of autoimmune interstitial lung diseases (Ai-ILD) is limited. The aim of the study was to evaluate the characteristics of patients diagnosed with Ai-ILD in Latin-America. We conducted an ambispective multicenter cohort study in 25 centers of Argentina, Colombia, and Uruguay between January 2015 and April 2018. Read More

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December 2018

Standardize the Surgical Technique and Clarify the Relevant Anatomic Concept for Complete Mobilization of Colonic Splenic Flexure Using da Vinci Xi Robotic System.

World J Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei, Taiwan, ROC.

Background: The present study is to set up a standardized approach for complete mobilization of colonic splenic flexure using da Vinci Xi robotic system, based on clarification of the mesenteric structures of distal transverse colon.

Methods: The surgical outcomes and relevant anatomic structures of 104 consecutive patients undergoing robotic resection of primary colorectal cancer with the intent of complete mobilization of colonic splenic flexure using da Vinci Xi robotic system were retrospectively reviewed.

Results: Complete mobilization of colonic splenic flexure can be efficiently performed by the Xi robotic system, as demonstrated by short operation time, minimal intra-operative blood loss, and few surgical complications. Read More

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December 2018

Evaluation of Poly (Carbonate-Urethane) Urea (PCUU) Scaffolds for Urinary Bladder Tissue Engineering.

Ann Biomed Eng 2018 Dec 12. Epub 2018 Dec 12.

Department of Bioengineering, Clemson University, Clemson, SC, USA.

Although the previous success of bladder tissue engineering demonstrated the feasibility of this technology, most polyester based scaffolds used in previous studies possess inadequate mechanical properties for organs that exhibit large deformation. The present study explored the use of various biodegradable elastomers as scaffolds for bladder tissue engineering and poly (carbonate-urethane) urea (PCUU) scaffolds mimicked urinary bladder mechanics more closely than polyglycerol sebacate-polycaprolactone (PGS-PCL) and poly (ether-urethane) urea (PEUU). The PCUU scaffolds also showed cyto-compatibility as well as increased porosity with increasing stretch indicating its ability to aid in infiltration of smooth muscle cells. Read More

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December 2018

Structure, asymmetry, and connectivity of the human temporo-parietal aslant and vertical occipital fasciculi.

Brain Struct Funct 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Stanford University, 300 Pasteur Drive Palo Alto, 94304, California, USA.

We previously proposed a bipartite 'dorsal-ventral' model of human arcuate fasciculus (AF) morphology. This model does not, however, account for the 'vertical,' temporo-parietal subdivision of the AF described in earlier dissection and tractographic studies. In an effort to address the absence of the vertical AF (VAF) within 'dorsal-ventral' nomenclature, we conducted a dedicated tractographic and white-matter dissection study of this tract and another short, vertical, posterior-hemispheric fascicle: the vertical occipital fasciculus (VOF). Read More

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December 2018

Roles of the endoplasmic reticulum-resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease.

J Biol Chem 2018 Dec 12. Epub 2018 Dec 12.

Dept. of Molecular & Cellular Biology, Kyoto Sangyo University, Japan.

Heat shock protein 47 (Hsp47) is an endoplasmic reticulum (ER)-resident molecular chaperone essential for correct folding of procollagen in mammalian cells. In this review, we discuss the role and function of Hsp47 in vertebrate cells and its role in connective tissue disorders. Hsp47 binds to collagenous (Gly-Xaa-Arg) repeats within triple-helical procollagen in the ER and can prevent its local unfolding or aggregate formation, resulting in accelerating triple-helix formation of procollagen. Read More

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December 2018

Pre-travel counseling for immunocompromised travelers: A 12-year single-center retrospective review.

Infect Dis Health 2018 Oct 26. Epub 2018 Oct 26.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.

Background: Immunocompromised travelers (ICTs) are medically complex and challenging for travel medicine providers. Our study hypothesizes that ICTs have high-risk travel itineraries and do not have adequate immunity against vaccine-preventable infections.

Methods: This retrospective review of 321 ICTs from 2004 to 2015 included patients with solid organ transplant (SOT, n = 134), connective tissue disease (CTD, n = 121), inflammatory bowel disease (IBD, n = 46), and human immunodeficiency virus (HIV, n = 20). Read More

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October 2018

Diagnostic value of ultrasonography in peroneal neuropathy

Turk J Med Sci 2018 12 12;48(6):1115-1120. Epub 2018 Dec 12.

Department of Neurology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey

Background/aim: Peroneal neuropathy at the fibular head (PNFH) is one of the most common entrapment neuropathies. Our aim in this study was to analyze the efficiency of ultrasonography in the diagnosis of PNFH.

Materials And Methods: The study included 15 peroneal nerves of 12 patients with PNFH and 24 peroneal nerves of 12 healthy controls. Read More

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December 2018

Overlap Syndrome-Systemic Sclerosis, Systemic Lupus Erythematosus and Dermatomyositis - Case Report.

Curr Health Sci J 2015 Jul-Sep;41(3):269-273. Epub 2015 Mar 15.

4University of Medicine and Pharmacy of Craiova, Rheumatology Department.

Overlap syndrome is often defined as an entity that satisfies the classification criteria for at least two distinct connective tissue disease. We present the case of a female patient, 39 years old, hospitalized in the Dermatology clinic of Emergency County Hospital in september 2014, for ulcerative lesions on the left hallux and the second and third left toes, associated with pain and difficulties in walking. After performing the clinical exam and paraclinical tests, we decided for both intravenous synthetic analogue of prostacyclin PGI2-iloprost and local therapeutic measures, with a favourable outcome of the ulcerations. Read More

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Afferent nerve fibres in the wall of the rat urinary bladder.

Authors:
Giorgio Gabella

Cell Tissue Res 2018 Dec 7. Epub 2018 Dec 7.

University College London, WC1E 6BT, London, UK.

Structure and distribution of afferent nerve fibres in the rat bladder were studied by fluorescence microscopy after selective staining with antibodies against neuropeptide CGRP. Afferent fibres are very abundant (by comparison with other viscera) and interconnected in all bladder parts: muscle, urothelium, connective tissue, blood vessels, serosa. Their highest concentration is beneath the urothelium in equatorial and caudal regions, where they form a plexus, while individually maintaining a tree-like structure with innumerable branches running without preferential orientation. Read More

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December 2018

A Female Patient with Xq28 Microduplication Presenting with Myotubular Myopathy, Confirmed with a Custom-Designed X-array.

Neuropediatrics 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Genetics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

X-linked myotubular myopathy (XLMTM) is a rare inherited neuromuscular disorder associated with mutations in the gene on the Xq28 region. We report a severely affected girl with XLMTM, caused by maternally inherited 661 kb Xq28 microduplication identified by chromosomal microarray analysis and confirmed also on DNA from muscle biopsy with a custom-designed X-chromosome-specific microarray. X-inactivation analysis revealed a skewed inactivation pattern on the proband's muscle biopsy. Read More

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December 2018
1 Read

Diastolic dysfunction in rheumatoid arthritis patients with low disease activity.

Clin Rheumatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Ul. Jaczewskiego 8, 20-950, Lublin, Poland.

Introduction/objectives: Patients with rheumatoid arthritis (RA) are at increased risk for congestive heart failure (CHF) and left ventricular diastolic dysfunction (LVDD), as compared to the general population. High disease activity is to be associated with higher incidence of cardiovascular disease (CVD), CHF, and mortality in RA patients. LVDD is not anticipated in RA patients without CVD symptoms and may be underdiagnosed especially in those with low disease activity. Read More

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December 2018

Contribution of Nail Fold Videocapillaroscopy in Patients with Early Inflammatory Arthritis.

Curr Health Sci J 2015 Jul-Sep;41(3):233-238. Epub 2015 Mar 15.

Rheumatology Department, University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Romania.

Background: Early inflammatory arthritis (EIA) a condition defined by joint swelling, with or without morning stiffness, and/or swelling of metacarpophalangeal and/or metatarsophalangeal joints. Nail fold video-capillaroscopy (NVC) is important for the evaluation of microcirculation in vivo. There are limited data about the role of NVC in EIA. Read More

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Diagnosis of asymptomatic aortic dissection during pregnancy using contrast echocardiography.

J Cardiol Cases 2014 May 24;9(5):200-202. Epub 2014 Feb 24.

Cardiovascular Division, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Spontaneous aortic dissection in pregnancy is rare and life-threatening for both the mother and the fetus. It is commonly associated with connective tissue disorders or aortic valvular abnormalities. We describe a case of a hypertensive pregnant woman in whom a dilated ascending aorta was identified in a routine transthoracic echocardiogram. Read More

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May 2014
1 Read

Right-sided cervical aortic arch in Loeys-Dietz syndrome.

J Cardiol Cases 2015 Feb 22;11(2):60-61. Epub 2014 Nov 22.

Department of Echocardiography, Day General Hospital, Tehran, Iran.

Loeys-Dietz syndrome is an autosomal dominant connective tissue disorder that is characterized by skeletal abnormalities, craniofacial malformations, and predisposition for aortic aneurysm with tortuosity. We report a case of a right-sided cervical aortic arch associated with the Loeys-Dietz syndrome. To the best of our knowledge, this combination has not been described in the literature. Read More

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February 2015
1 Read

Multivessel spontaneous coronary artery dissection associated with hormonal infertility therapy in a 39-year-old female.

J Cardiol Cases 2012 Apr 6;5(2):e69-e72. Epub 2012 Mar 6.

Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Spontaneous coronary artery dissection (SCAD) is a rare and potentially lethal cause of chest pain and myocardial infarction in healthy young individuals. It more commonly affects females and has been correlated with hormonally-induced connective tissue changes in pregnancy and oral contraceptive use. We present the case of a previously healthy 39-year-old woman with multivessel SCAD associated with recent clomiphene and gonadotropin therapy for infertility, which is not a previously reported association, and we assert that this should be in the differential diagnosis of such patients with chest pain or myocardial infarction. Read More

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Pulmonary hypertension associated with veno-occlusive disease in systemic sclerosis: Insight into the mechanism of resistance to vasodilator.

J Cardiol Cases 2012 Feb 6;5(1):e44-e47. Epub 2011 Dec 6.

Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

We report a case with pulmonary veno-occlusive disease (PVOD) associated with systemic sclerosis which exhibits strong resistance to pulmonary vasodilator. A 55-year-old female with severe pulmonary hypertension was admitted to our hospital to be introduced to epoprostenol infusion therapy. She was diagnosed as having pulmonary arterial hypertension (PAH) associated with systemic sclerosis at the age of 51. Read More

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February 2012

Strain State Dependent Anisotropic Viscoelasticity of Tendon-to-Bone Insertion.

Math Biosci 2018 Dec 8. Epub 2018 Dec 8.

Mechanical and Aerospace Engineering Department, North Carolina State University, R3158 Engineering Building 3, Campus Box 7910, 911 Oval Drive, Raleigh, NC 27695. Electronic address:

Tendon-to-bone insertion tissues may be considered as functionally-graded connective tissues, providing a gradual transition from soft tendon to hard bone tissue, and functioning to alleviate stress concentrations at the junction of these tissues. The tendon-to-bone insertion tissues demonstrate pronounced viscoelastic behavior, like many other biological tissues, and are designed by the nature to alleviate stress at physiological load rates and strains states. In this paper we present experimental data showing that under biaxial tension tendon-to-bone insertion demonstrates rate-dependent behavior and that stress-strain curves for the in-plane components of stress and strain become less steep when strain rate is increased, contrary to a typical viscoelastic behavior, where the opposite trend is observed. Read More

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December 2018
3 Reads

Quantifying Proliferative and Surface Marker Heterogeneity in Colony Founding Connective Tissue Progenitors and Their Progeny Using Time-Lapse Microscopy.

J Tissue Eng Regen Med 2018 Dec 7. Epub 2018 Dec 7.

Dept. of Biomedical Engineering, Cleveland Clinic, Cleveland, OH.

Connective tissue progenitors (CTPs) are defined as the heterogeneous population of tissue-resident stem and progenitor cells that are capable of proliferating and differentiating into connective tissue phenotypes. The prevalence and variation in clonal progeny of CTPs can be characterized using a colony formation assay. However, colony assays do not directly assess the characteristics of the colony founding CTP. Read More

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December 2018

The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study.

Int Urogynecol J 2018 Dec 10. Epub 2018 Dec 10.

Department of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Introduction And Hypothesis: Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with postmenopausal women without POP. Furthermore, we identified clinical risk factors associated with POP in our study population. Read More

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December 2018

Periodontal Ehlers-Danlos syndrome is associated with leukoencephalopathy.

Neurogenetics 2018 Dec 8. Epub 2018 Dec 8.

Department of Child Neurology and Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Here, we report brain white matter alterations in individuals clinically and genetically diagnosed with periodontal Ehlers-Danlos syndrome, a rare disease characterized by premature loss of teeth and connective tissue abnormalities. Eight individuals of two families clinically diagnosed with periodontal Ehlers-Danlos syndrome were included in the present study and underwent general physical, dental, and neurological examination. Whole exome sequencing was performed, and all patients included in the study underwent MRI of the brain. Read More

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December 2018
1 Read

Genomic characterization, phylogenetic position and in situ localization of a novel putative mononegavirus in Lepeophtheirus salmonis.

Arch Virol 2018 Dec 7. Epub 2018 Dec 7.

Sea Lice Research Centre, Department of Biological Sciences, University of Bergen, Thormøhlensgt. 55, Pb. 7803, 5020, Bergen, Norway.

The complete genome sequence of a novel mononegavirus, Lepeophtheirus salmonis negative-stranded RNA virus 1 (LsNSRV-1), obtained from a salmonid ectoparasite, Lepeophtheirus salmonis was determined. The viral genome contains five open reading frames encoding three unknown proteins (ORF I, II and III), a putative glycoprotein (G), and a large (L) protein. Phylogenetic analysis placed LsNSRV-1 in the recently established mononegaviral family Artoviridae. Read More

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December 2018

[Suspected vascular ehlers danlos syndrome. Case report].

Rev Med Chil 2018 Aug;146(8):938-942

Departamento de Dermatología, Pontificia Universidad Católica de Chile, Santiago, Chile.

Ehlers Danlos Syndrome comprises a heterogeneous group of genetic disorders of the connective tissue, due to defects in collagen or its modifying enzymes. We report a 21 years old male presenting with translucent skin revealing the subcutaneous venous pattern. He had a thin face, large-appearing eyes, thin lips, thin nose, joint hypermotility and history of hip dysplasia. Read More

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Morphological changes of gums in occlusal trauma.

Rom J Morphol Embryol 2018 ;59(3):787-802

Department of Occlusology and Fixed Prosthetics, University of Medicine and Pharmacy of Craiova, Romania;

Aim: Occlusal trauma causes major modifications of the coverage periodontium, which in turn reflect on the dental unit. The aim of the present study is to evaluate some of the morphological modifications occurred in the marginal periodontium surrounding teeth affected by occlusal trauma.

Materials And Methods: Fragments of marginal periodontium coming from 51 patients with occlusal trauma were processed using classical histological techniques (formalin fixation and paraffin embedment) and stained with Hematoxylin-Eosin (HE), Masson's trichrome and anti-CD34 antibody immunostaining, in order to highlight the epithelial and connective tissue changes of gingival mucosa. Read More

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January 2018

Quantitative assessment of morphological changes of dental pulp components of teeth affected by occlusal trauma.

Rom J Morphol Embryol 2018 ;59(3):729-740

Department of Occlusology and Fixed Prosthetics, University of Medicine and Pharmacy of Craiova, Romania;

Aim: In the general economy of the stomatognathic system functionality, the occlusal function has an important role, meaning both the dental-dental reports and the dynamic reports interarch-interarch. Because of the interrelationships and inter-dependency that govern the functioning of the biological systems, a pathological change affecting a component of the stomatognathic system produces impaired functioning of the others. The aim of the present study is to assess the morphological changes occurred in the dental pulp components of teeth affected by occlusal trauma. Read More

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January 2018

Mixed connective tissue disease in young Saudi patient with recurrent dental abscess: A case report.

Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):65-68

Department of Paediatric, Paediatric Rheumatology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Mixed connective tissue disease (MCTD) or overlap syndrome is a rare disease. It has overlapping features of more than one autoimmune disease with high titer of anti-ribonucleoprotein antibodies against U1. We present a 12-year-old Saudi male patient who was presented to the dental clinic complaining from non-healing oral ulcers and multiple periapical abscesses that not responsive to extractions and the use of oral antibiotics, these symptoms were accompanied with persistent fever, headache, muscle weakness, general malaise, and painful bilateral cervical lymphadenopathy. Read More

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December 2018

Knee Arthroscopy: A Diagnostic and Therapeutic Tool for Management of Ochronotic Arthropathy.

Arthrosc Tech 2018 Nov 1;7(11):e1097-e1101. Epub 2018 Oct 1.

Stetson Powell Orthopedics and Sports Medicine, Burbank, California, U.S.A.

The surgical treatment of ochronotic arthropathy remains unclear. Although there is no absolute cure for ochronotic arthropathy, current management typically begins with conservative treatment. Total joint replacement may eventually be necessary for joints that become severely degenerative. Read More

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November 2018

A novel primary culture method for high-purity satellite glial cells derived from rat dorsal root ganglion.

Neural Regen Res 2019 Feb;14(2):339-345

Institute of Neuroscience, Kunming Medical University, Kunming, Yunnan Province, China.

Satellite glial cells surround neurons within dorsal root ganglia. Previous studies have focused on single-cell suspensions of cultured neurons derived from rat dorsal root ganglia. At present, the primary culture method for satellite glial cells derived from rat dorsal root ganglia requires no digestion skill. Read More

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February 2019

Salvianolic acid B attenuates experimental skin fibrosis of systemic sclerosis.

Biomed Pharmacother 2018 Dec 7;110:546-553. Epub 2018 Dec 7.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China; Department of dermatology, Jing'an District Central Hospital, Shanghai, China. Electronic address:

Systemic sclerosis (SSc) is a connective tissue disease characterized mainly by fibrosis of skin and internal organs. Our previous study has shown that salvianolic acid B (SAB), a bioactive component extracted from Salvia miltiorrhiza (SM), was one of the essential ingredients in the traditional Chinese medicine Yiqihuoxue formula, which has been used to treat SSc-related dermal and pulmonary fibrosis. The aim of the present study was to evaluate the effect of SAB on skin fibrosis and explore its underlying anti-fibrotic mechanism. Read More

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December 2018
1 Read

Clinicopathological study of role of CD34 expressions in the stroma of premalignant and malignant lesions of uterine cervix.

Ann Diagn Pathol 2018 Nov 29;38:87-92. Epub 2018 Nov 29.

Department of Pathology, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh, India.

CD34 is a transmembrane glycoprotein that is thought to be involved in the modulation of cell adhesion and signal transduction. The connective tissue stroma of virtually all human organs contain large amounts of resident CD34+ fibrocytes, which are involved in multiple functions such as wound healing, secretion of cytokines and also participate in stromal remodeling. It has been seen in various studies that absence of CD34+ fibrocytes within the stroma is associated with invasive carcinomas. Read More

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November 2018

Evaluation of teriparatide effect on healing of autografted mandibular defects in rats.

J Craniomaxillofac Surg 2018 Nov 23. Epub 2018 Nov 23.

Department of Biostatistics and Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: To evaluate the effects of short-term teriparatide administration on healing of autologous bone graft in mandibular critical-size defects.

Subjects And Methods: A 5-mm mandibular bone defect was created and iliac bone graft was harvested in 135 rats. Rats were randomly divided into 3 groups of negative control (NC), control (C), and study (S). Read More

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November 2018

Hypoxia: A breath of fresh air for the meibomian gland.

Ocul Surf 2018 Dec 4. Epub 2018 Dec 4.

Schepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston, 02114, USA.

Purpose: Optimal meibomian gland (MG) function is critically important for the health and wellbeing of the ocular surface. We hypothesize that low oxygen (O) conditions promote the function of human MG epithelial cells (HMGECs) and that human MGs exist in a relatively hypoxic environment. The purpose of this study was to test our hypotheses. Read More

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December 2018
1 Read

Update on the epidemiology, risk factors, and disease outcomes of systemic sclerosis.

Best Pract Res Clin Rheumatol 2018 04 14;32(2):223-240. Epub 2018 Sep 14.

Department of Rheumatology, Zurich University Hospital, Zurich, Switzerland; Department of Internal Medicine and Rheumatology, Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Electronic address:

Systemic sclerosis (SSc) is a chronic immune-mediated connective tissue disease with heterogeneous organ involvement. New classification criteria were developed allowing disease identification even before the onset of its hallmark, skin fibrosis. Incidence and prevalence vary among reports and are influenced by methodology. Read More

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Mulberry leaf polysaccharides suppress renal fibrosis.

Authors:
Shengjun Wu

Int J Biol Macromol 2018 Dec 3;124:1090-1093. Epub 2018 Dec 3.

Jiangsu Key Laboratory of Marine Bioresources and Environment, Huaihai Institute of Technology, 59 Cangwu Road, Haizhou 222005, China; Co-Innovation Center of Jiangsu Marine Bio-industry Technology, 59 Cangwu Road, Haizhou 222005, China; Jiangsu Key Laboratory of Marine Biotechnology, 59 Cangwu Road, Haizhou 222005, China. Electronic address:

A mulberry leaf polysaccharide (MLP-1) was prepared and partially characterised, and its anti-renal-fibrosis effects were investigated in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats. MLP-1, with a molecular weight of 2,792,624 Da, consisted of arabinose, glucose, xylose, rhamnose, and mannose in a molar ratio of 1:1.13:2. Read More

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December 2018
2 Reads

Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5.

PLoS One 2018 6;13(12):e0207826. Epub 2018 Dec 6.

Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Uppsala, Sweden.

Serine proteases constitute the major protein content of mast cell secretory granules. Here we present the extended cleavage specificity of two such proteases from the golden hamster, Mesocricetus auratus. Analysis by phage display technique showed that one of them (HAM1) is a classical chymase with a specificity similar to the human mast cell chymase. Read More

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December 2018
5 Reads

Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.

Glycosaminoglycans (GAGs) are linear, highly negatively charged carbohydrate chains present in connective tissues. Chondroitin sulfate (CS) and heparin (Hep) are also found in the numerous secretory granules of mast cells (MC), tissue immune cells involved in allergic and inflammatory reactions. CS and Hep may inhibit secretion of histamine from rat connective tissue MC, but their effect on human MC remains unknown. Read More

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December 2018
1 Read

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra.

J Biomed Opt 2018 Dec;23(12):1-6

California Institute of Technology, Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Depa, United States.

Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. Read More

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December 2018
10 Reads
2.859 Impact Factor

Unexpected photosensitivity - a patient with dermatomyositis and concomitant solar urticaria.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Dept. of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany.

Dermatomyositis (DM) is a connective tissue disease with rare incidence, characterized by progressive muscle weakness and typical cutaneous manifestations. Its pathogenesis is still incompletely understood, but next to genetic predisposition environmental factors seem to be implicated in the development of DM (1). Photosensitivity is one important factor for the onset and exacerbation of DM, which is corroborated by the distribution of the cutaneous features on sun-exposed areas and disease photoaggravation (2,3). Read More

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December 2018
1 Read

Long-range projections from sparse populations of GABAergic neurons in murine subplate.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiology, Anatomy and Genetics, Parks Road, Oxford.

The murine subplate contains some of the earliest generated populations of neurons in the cerebral cortex, which play an important role in the maturation of cortical inhibition. Here we present multiple lines of evidence, that the subplate itself is only very sparsely populated with GABAergic neurons at postnatal day (P)8. We used three different transgenic mouse lines, each of which labels a subset of GABAergic, ganglionic eminence derived neurons. Read More

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December 2018
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3.225 Impact Factor

uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.

Nat Commun 2018 12 5;9(1):5178. Epub 2018 Dec 5.

Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University, B23, Avenue Hippocrate 13, 4000, Liege, Belgium.

The development of new lymphatic vessels occurs in many cancerous and inflammatory diseases through the binding of VEGF-C to its receptors, VEGFR-2 and VEGFR-3. The regulation of VEGFR-2/VEGFR-3 heterodimerisation and its downstream signaling in lymphatic endothelial cells (LECs) remain poorly understood. Here, we identify the endocytic receptor, uPARAP, as a partner of VEGFR-2 and VEGFR-3 that regulates their heterodimerisation. Read More

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December 2018

Pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a dog.

Acta Vet Scand 2018 Dec 5;60(1):78. Epub 2018 Dec 5.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3508 TD, Utrecht, The Netherlands.

Background: Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension (PAH) in humans and can be classified in idiopathic, heritable, drug and radiation-induced, and associated with connective tissue disease or human immunodeficiency virus infection. Recently, biallelic mutations of the EIF2AK4 gene have been discovered as a cause for an autosomal recessive form of PVOD in humans. In dogs, PAH is poorly characterized and is generally considered to be idiopathic or secondary to (for example) congenital left-to right cardiovascular shunts or heartworm disease. Read More

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December 2018
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